PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24650357-2	2014	Dihydropteroate synthase (DHPS) catalyzes a crucial step in the bacterial pathway of folic acid synthesis, a pathway that is absent in higher vertebrates.	Folic Acid	85-95	deoxyhypusine synthase	Homo sapiens	0-24	
24650357-2	2014	Dihydropteroate synthase (DHPS) catalyzes a crucial step in the bacterial pathway of folic acid synthesis, a pathway that is absent in higher vertebrates.	Folic Acid	85-95	deoxyhypusine synthase	Homo sapiens	26-30	
21554707-1	2011	BACKGROUND: The enzyme dihydropteroate synthase (DHPS) participates in the de novo synthesis of folate cofactors by catalyzing the formation of 7,8-dihydropteroate from condensation of p-aminobenzoic acid with 6-hydroxymethyl-7,8-dihydropteroate pyrophosphate.	Folic Acid	96-102	deoxyhypusine synthase	Homo sapiens	49-53	
27025730-5	2014	An additional anti-folate target is dihyropteroate synthase (DHPS), which is unique to prokaryotes as they cannot acquire folate through dietary means.	Folic Acid	19-25	deoxyhypusine synthase	Homo sapiens	61-65	
27025730-5	2014	An additional anti-folate target is dihyropteroate synthase (DHPS), which is unique to prokaryotes as they cannot acquire folate through dietary means.	Folic Acid	122-128	deoxyhypusine synthase	Homo sapiens	61-65	
27025730-10	2014	These inhibitors are also likely to interact with the enzymatic neighbors in the folate pathway that bind products of the DHFR or DHPS enzymes and/or substrates of similar substructure.	Folic Acid	81-87	deoxyhypusine synthase	Homo sapiens	130-134	
21554707-2	2011	DHPS is absent from humans, who acquire folates from diet, and has been validated as an antimicrobial therapeutic target by chemical and genetic means.	Folic Acid	40-47	deoxyhypusine synthase	Homo sapiens	0-4	
17134675-1	2007	The enzymes 6-hydroxymethylpterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) catalyze sequential steps in folate biosynthesis.	Folic Acid	124-130	deoxyhypusine synthase	Homo sapiens	63-87	
20821592-4	2010	Sulfonamides inhibit the growth of sensitive microorganisms by competitive binding to the dihydropteroate-synthase (DHPS) enzyme of folic acid production.	Folic Acid	132-142	deoxyhypusine synthase	Homo sapiens	90-114	
20821592-4	2010	Sulfonamides inhibit the growth of sensitive microorganisms by competitive binding to the dihydropteroate-synthase (DHPS) enzyme of folic acid production.	Folic Acid	132-142	deoxyhypusine synthase	Homo sapiens	116-120	
18500934-8	2008	RESULTS: The target gene was identified among genes encoding a unique trifunctional enzyme in which DHPS is combined with the 2 preceding enzymes of the folate biosynthesis pathway.	Folic Acid	153-159	deoxyhypusine synthase	Homo sapiens	100-104	
18500934-10	2008	Gene complementation showed that the gene encoding putative DHPS restored the folate biosynthesis pathway and susceptibility to sulfamethoxazole, whereas the mutated sequence was associated with sulfamethoxazole resistance.	Folic Acid	78-84	deoxyhypusine synthase	Homo sapiens	60-64	
17134675-1	2007	The enzymes 6-hydroxymethylpterin pyrophosphokinase (HPPK) and dihydropteroate synthase (DHPS) catalyze sequential steps in folate biosynthesis.	Folic Acid	124-130	deoxyhypusine synthase	Homo sapiens	89-93	
11498380-3	2000	The target of sulfonamides, and the basis for their selectivity, is the enzyme dihydropteroate synthase (DHPS) in the folic acid pathway.	Folic Acid	118-128	deoxyhypusine synthase	Homo sapiens	79-103	
11498380-3	2000	The target of sulfonamides, and the basis for their selectivity, is the enzyme dihydropteroate synthase (DHPS) in the folic acid pathway.	Folic Acid	118-128	deoxyhypusine synthase	Homo sapiens	105-109	
10533864-2	1999	Sulpha resistance in many microorganisms is caused by point mutations in dihydropteroate synthase (DHPS), an enzyme that is essential for folate biosynthesis.	Folic Acid	138-144	deoxyhypusine synthase	Homo sapiens	99-103