PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22147198-2	2012	The steady-state accumulation of folate seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them, enabling it to be transported across the biological membranes.	Folic Acid	33-39	folylpolyglutamate synthase	Rattus norvegicus	88-117	
22147198-3	2012	Overexpression of GGH and downregulation of FPGS would be expected to decrease intracellular folate in its polyglutamylated form, thereby increasing efflux of folate and its related molecules, which might lead to resistance to drugs or folate deficiency.	Folic Acid	93-99	folylpolyglutamate synthase	Rattus norvegicus	44-48	
22147198-3	2012	Overexpression of GGH and downregulation of FPGS would be expected to decrease intracellular folate in its polyglutamylated form, thereby increasing efflux of folate and its related molecules, which might lead to resistance to drugs or folate deficiency.	Folic Acid	159-165	folylpolyglutamate synthase	Rattus norvegicus	44-48	
22147198-4	2012	The study was sought to delineate the activity of GGH and expression FPGS in tissues involved in folate homeostasis during alcoholism and the epigenetic regulation of these enzymes and transporters regulating intracellular folate levels.	Folic Acid	97-103	folylpolyglutamate synthase	Rattus norvegicus	69-73	
22147198-2	2012	The steady-state accumulation of folate seems to depend on the activity of two enzymes: folylpolyglutamate synthetase (FPGS), which adds glutamate residues, and gamma-glutamyl hydrolase (GGH), which removes them, enabling it to be transported across the biological membranes.	Folic Acid	33-39	folylpolyglutamate synthase	Rattus norvegicus	119-123	
3873989-12	1985	The activities of folate and antifolate substrates also have been determined with rat liver FPGS.	Folic Acid	18-24	folylpolyglutamate synthase	Rattus norvegicus	92-96	
2451560-3	1988	The depletion of cellular folates produced comparable increases in both cellular methotrexate glutamylation and extract FPGS activity (approximately 1.8-fold).	Folic Acid	26-33	folylpolyglutamate synthase	Rattus norvegicus	120-124	
6201178-8	1984	It was further shown that the relative substrate activity of folate analogs for folylpolyglutamate synthetase is dependent on the source of the enzyme.	Folic Acid	61-67	folylpolyglutamate synthase	Rattus norvegicus	80-109