PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18029487-9	2007	DNA strand breaks within the Apc mutation cluster region were induced by folate depletion combined with inadequacies of riboflavin, vitamin B-6, and vitamin B-12 (P < 0.05), but such effects were not induced by folate depletion alone.	Folic Acid	73-79	APC, WNT signaling pathway regulator	Mus musculus	29-32	
17868491-0	2008	Gender-specific modulation of tumorigenesis by folic acid supply in the Apc mouse during early neonatal life.	Folic Acid	47-57	APC, WNT signaling pathway regulator	Mus musculus	72-75	
17868491-11	2008	These data suggest that folate depletion post-weaning was protective against neoplasia in female Apc+/Min mice and highlights the need for further investigation of the optimal timing and dose of folic acid supplementation with regard to colorectal cancer risk.	Folic Acid	24-30	APC, WNT signaling pathway regulator	Mus musculus	97-100	
22303319-13	2011	Low post-weaning folate increased Apc methylation in Apc(+/Min) mice only (p = 0.008 for interaction).	Folic Acid	17-23	APC, WNT signaling pathway regulator	Mus musculus	34-37	
22303319-13	2011	Low post-weaning folate increased Apc methylation in Apc(+/Min) mice only (p = 0.008 for interaction).	Folic Acid	17-23	APC, WNT signaling pathway regulator	Mus musculus	53-56	
22303319-15	2011	Also, the differential effects of altered folate supply on DNA methylation in WT and Apc(+/Min) mice suggest that genotype may modulate epigenetic responses to environmental cues and may have implications for the development of personalized nutrition.	Folic Acid	42-48	APC, WNT signaling pathway regulator	Mus musculus	85-88	
19174418-0	2009	Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.	Folic Acid	19-25	APC, WNT signaling pathway regulator	Mus musculus	94-97	
19174418-7	2009	RESULTS: Apc(min/+) mice fed high folate diets from weaning developed more adenomas than those fed the folic acid-deficient diet (FADD) or the control diet (CD); Mthfr deficiency did not affect adenoma number.	Folic Acid	34-40	APC, WNT signaling pathway regulator	Mus musculus	9-12	
18029487-9	2007	DNA strand breaks within the Apc mutation cluster region were induced by folate depletion combined with inadequacies of riboflavin, vitamin B-6, and vitamin B-12 (P < 0.05), but such effects were not induced by folate depletion alone.	Folic Acid	214-220	APC, WNT signaling pathway regulator	Mus musculus	29-32	
18029487-10	2007	Similarly, minor changes in the expression of Apc, beta-catenin, and cyclin D1 produced by mild folate depletion were significantly magnified by multiple vitamin depletion.	Folic Acid	96-102	APC, WNT signaling pathway regulator	Mus musculus	46-49	
11756224-5	2002	In folate-adequate Min mice, we identified positive linear correlations between SAM or SAH and tumor numbers (R(2) = 0.38, P < 0.005; R(2) = 0.26, P = 0.025, respectively).	Folic Acid	3-9	APC, WNT signaling pathway regulator	Mus musculus	19-22