PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34960114-1 2021 The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key functions in the one-carbon cycle, which include methionine and folate metabolism and protein, DNA, and RNA synthesis. Folic Acid 173-179 methylenetetrahydrofolate reductase Homo sapiens 4-44 33802362-3 2021 MTHFR(677) CT and TT genotypes have been associated with a greater risk of low birth weight, especially in case of deficient intake of folic acid during pregnancy. Folic Acid 135-145 methylenetetrahydrofolate reductase Homo sapiens 0-5 33802362-4 2021 This study aimed to analyze the association between the maternal MTHFR(677)C>T genetic polymorphism and anthropometry at birth in a population with adequate folate consumption. Folic Acid 157-163 methylenetetrahydrofolate reductase Homo sapiens 65-70 16002796-3 2005 OBJECTIVE: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype. Folic Acid 25-35 methylenetetrahydrofolate reductase Homo sapiens 125-160 16002796-3 2005 OBJECTIVE: The effect of folic acid supplementation on blood pressure and large artery stiffness was examined in relation to methylenetetrahydrofolate reductase (MTHFR) genotype. Folic Acid 25-35 methylenetetrahydrofolate reductase Homo sapiens 162-167 16002796-9 2005 MTHFR genotype CC homozygotes (without the 677C-->T polymorphism) with normal blood pressure had a larger reduction in homocysteine concentrations in response to folic acid than did T allele carriers. Folic Acid 165-175 methylenetetrahydrofolate reductase Homo sapiens 0-5 34967850-8 2022 RESULTS: After correction for multiple comparisons, among NHW women, 5,10-methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C T) variant T was associated with lower plasma folate (-13.0%, 95% CI = -17.3% to -8.6%) and higher plasma homocysteine (3.5%, 95% CI = 1.7% to 5.3%) concentrations. Folic Acid 180-186 methylenetetrahydrofolate reductase Homo sapiens 69-109 34967850-8 2022 RESULTS: After correction for multiple comparisons, among NHW women, 5,10-methylenetetrahydrofolate reductase (MTHFR) rs1801133 (677C T) variant T was associated with lower plasma folate (-13.0%, 95% CI = -17.3% to -8.6%) and higher plasma homocysteine (3.5%, 95% CI = 1.7% to 5.3%) concentrations. Folic Acid 180-186 methylenetetrahydrofolate reductase Homo sapiens 111-116 34967850-11 2022 Highest vs. lowest quartiles of aggregated genetic risk scores from SNVs in MTHFR and MTRR were associated with 14.8% to 18.9% lower RBC folate concentrations. Folic Acid 137-143 methylenetetrahydrofolate reductase Homo sapiens 76-81 34960114-1 2021 The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key functions in the one-carbon cycle, which include methionine and folate metabolism and protein, DNA, and RNA synthesis. Folic Acid 173-179 methylenetetrahydrofolate reductase Homo sapiens 46-51 34836291-2 2021 Similarly to B12 and B6, vitamin B9 is involved in the metabolism of homocysteine, which is associated with the MTHFR gene. Folic Acid 25-35 methylenetetrahydrofolate reductase Homo sapiens 112-117 34369004-1 2021 BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, which is expressed in human oocytes and preimplantation. Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 16-56 34761111-1 2021 MTHFR is a crucial enzyme in folate metabolism. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 0-5 34502300-3 2021 Methylenetetrahydrofolate reductase (MTHFR) is the enzyme catalyzing the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that can control folate cofactor distributions and modulate the partitioning of intracellular one-carbon moieties. Folic Acid 176-182 methylenetetrahydrofolate reductase Homo sapiens 0-35 34502300-3 2021 Methylenetetrahydrofolate reductase (MTHFR) is the enzyme catalyzing the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that can control folate cofactor distributions and modulate the partitioning of intracellular one-carbon moieties. Folic Acid 176-182 methylenetetrahydrofolate reductase Homo sapiens 37-42 34369004-1 2021 BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, which is expressed in human oocytes and preimplantation. Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 58-63 34289004-5 2021 RESULTS: Carriers of C/T and T/T genotypes of the MTHFR gene had higher levels of cholesterol and triglycerides and lower levels of vitamin B6 and folate. Folic Acid 147-153 methylenetetrahydrofolate reductase Homo sapiens 50-55 34376980-2 2021 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate conversion and methylation modification associated with the disease. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 0-35 34376980-2 2021 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate conversion and methylation modification associated with the disease. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 37-42 34242313-1 2021 Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 0-35 34242313-1 2021 Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 37-42 34128976-1 2021 5, 10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in the folate metabolic pathway with a key role in generating methyl groups. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 43-48 34204335-3 2021 OBJECTIVE: To determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20). Folic Acid 54-64 methylenetetrahydrofolate reductase Homo sapiens 144-149 34397023-9 2021 Results: Based on the genotype of MTHFR and MTRR, women were identified as five risk levels of folic acid metabolism. Folic Acid 95-105 methylenetetrahydrofolate reductase Homo sapiens 34-39 34214447-2 2021 Deficiency in human 5,10-methylenetetrahydrofolate reductase (MTHFR), the most common inherited disorder of folate metabolism, is caused primarily by rare missense variants. Folic Acid 108-114 methylenetetrahydrofolate reductase Homo sapiens 20-60 34214447-2 2021 Deficiency in human 5,10-methylenetetrahydrofolate reductase (MTHFR), the most common inherited disorder of folate metabolism, is caused primarily by rare missense variants. Folic Acid 108-114 methylenetetrahydrofolate reductase Homo sapiens 62-67 34214447-4 2021 An important example of this phenomenon is the MTHFR variant p.Ala222Val (c.665C>T), which is carried by half of all humans and has a phenotypic impact that depends on dietary folate. Folic Acid 176-182 methylenetetrahydrofolate reductase Homo sapiens 47-52 34122714-3 2021 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 0-35 34122714-3 2021 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 37-42 34522719-1 2021 Methyltetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism, and its single nucleotide polymorphism (SNP) site C677T may be associated with gastrointestinal cancer. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 34-39 34169999-13 2021 CONCLUSION: We reported significant association between genetic alterations of folate metabolism (MTHFR, MTRR) and DNA repair mechanism (RAD54L) genes with the histopathological characteristics of the meningioma tumors. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 98-103 1186901-0 1975 Folate-dependent 1-carbon transfer to biogenic amines mediated by methylenetetrahydrofolate reductase. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 66-101 35463099-0 2022 Association of MTHFR C677T (rs1801133) and A1298C (rs1801131) Polymorphisms with Serum Homocysteine, Folate and Vitamin B12 in Patients with Young Coronary Artery Disease. Folic Acid 101-107 methylenetetrahydrofolate reductase Homo sapiens 15-20 35463099-2 2022 The objective of this study was to evaluate the clinical usefulness of association between MTHFR C677T (rs1801133) and A1298C (rs1801131) polymorphisms with serum homocysteine, folate and vitamin B12 in addition to conventional cardiovascular risk factors in patients with young CAD. Folic Acid 177-183 methylenetetrahydrofolate reductase Homo sapiens 91-96 35346016-6 2022 Specifically, the most studied polymorphism is 677T-C in exon 5 of the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene, which plays an important role in folate"s metabolism. Folic Acid 160-166 methylenetetrahydrofolate reductase Homo sapiens 77-112 35346016-6 2022 Specifically, the most studied polymorphism is 677T-C in exon 5 of the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene, which plays an important role in folate"s metabolism. Folic Acid 160-166 methylenetetrahydrofolate reductase Homo sapiens 114-119 35268281-7 2022 However, the relationships between erythrocyte folate concentrations and the occurrence of alternative variants: c.665C>T MTHFR and c.776G>C TCN2, as well as the methylmalonic acid concentration and the occurrence of alternative variant c.776G>C TCN2 in pregnant women with fetal-T21, encourage further research. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 122-127 3143307-8 1988 Thus it is possible that the effect of thiouracil in increasing folate function consists both in the effect of thiouracil in decreasing levels of methylenetetrahydrofolate reductase, and also in its action in increasing S-adenosylmethionine which exerts a feedback inhibition of this enzyme. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 146-181 34045473-10 2021 In summary, the data of this study showed that minor allele (A) of rs55763075 polymorphisms in the 3"-untranslated region of MTHFR mRNA generated a potential binding site for miR-34b, which led to reduced level of folic acid in the patients carrying the AA genotype. Folic Acid 214-224 methylenetetrahydrofolate reductase Homo sapiens 125-130 34036101-3 2021 Methylenetetrahydrofolate reductase (MTHFR) gene mutation is related to elevated total homocysteine (tHct) expressions, in particular, among women with low folate intake. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 33920562-3 2021 5,10-methylene tetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate metabolism pathway that converts 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, which produces a methyl donor for the remethylation of homocysteine to methionine. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 43-48 33914208-1 2021 PURPOSE: MTHFR, one of the major enzymes in the folate cycle, is known to acquire single-nucleotide polymorphisms that significantly reduce its activity, resulting in an increase in circulating homocysteine. Folic Acid 48-54 methylenetetrahydrofolate reductase Homo sapiens 9-14 33859051-2 2021 In this prospective, multicentre cohort study, we investigated the association with treatment effectiveness and toxicity of 10 polymorphisms in nine candidate genes, covering the folate pathway (MTHFR), cell transport (SLC19A1/ABCC2/ABCC4), intracellular metabolism (FPGS/GGH) and target enzymes (TYMS/DHFR/ATIC) of pemetrexed. Folic Acid 179-185 methylenetetrahydrofolate reductase Homo sapiens 195-200 33923969-1 2021 Methylenetetrahydrofolate reductase (MTHFR) has various polymorphisms, and the effects of periconceptional folic acid supplementation for decreasing neural tube defects (NTDs) risk differ depending on the genotypes. Folic Acid 107-117 methylenetetrahydrofolate reductase Homo sapiens 0-35 33923969-1 2021 Methylenetetrahydrofolate reductase (MTHFR) has various polymorphisms, and the effects of periconceptional folic acid supplementation for decreasing neural tube defects (NTDs) risk differ depending on the genotypes. Folic Acid 107-117 methylenetetrahydrofolate reductase Homo sapiens 37-42 33923969-5 2021 In 54 women (26.3% of all women) with a risk of NTDs, multivitamin supplementation containing folic acid and vitamin D for one month increased folate level (5.8 +- 0.9 to 19.2 +- 4.0 ng/mL, p < 0.0001) and decreased the homocysteine level (8.2 +- 3.1 to 5.8 +- 0.8 nmol/mL, p < 0.0001) to minimize the risk of NTDs in all women, regardless of MTHFR genotype. Folic Acid 94-104 methylenetetrahydrofolate reductase Homo sapiens 343-348 33476699-2 2021 Intersecting these two cycles, 5,10-methylenetetrahydrofolate reductase (MTHFR) directs one-carbon units from the folate to methionine cycle, to be exclusively used for methionine and S-adenosylmethionine (AdoMet) synthesis. Folic Acid 55-61 methylenetetrahydrofolate reductase Homo sapiens 73-78 33672126-11 2021 Pharmacogenomic testing is being increasingly used to determine Single Nucleotide Polymorphisms in Cytochrome P450, Serotonin Transporter, COMT, folic acid conversion (MTHFR). Folic Acid 145-155 methylenetetrahydrofolate reductase Homo sapiens 168-173 32827402-5 2021 Studies involving folate supplementation for the treatment of depression have had mixed results but have omitted to take into account the genetic polymorphisms, such as the ones in methyltetrahydrofolate reductase (MTHFR), that affect folate metabolism. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 215-220 33486813-2 2021 The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene. Folic Acid 18-28 methylenetetrahydrofolate reductase Homo sapiens 88-93 33486813-2 2021 The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene. Folic Acid 18-28 methylenetetrahydrofolate reductase Homo sapiens 126-131 33486813-2 2021 The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 88-93 33486813-2 2021 The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 126-131 33411826-0 2021 Acute high folic acid treatment in SH-SY5Y cells with and without MTHFR function leads to gene expression changes in epigenetic modifying enzymes, changes in epigenetic marks, and changes in dendritic spine densities. Folic Acid 11-21 methylenetetrahydrofolate reductase Homo sapiens 66-71 33440639-1 2021 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway, and its loss of function through polymorphisms is often associated with human conditions, including cancer, congenital heart disease, and Down syndrome. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 33411826-2 2021 Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group. Folic Acid 24-34 methylenetetrahydrofolate reductase Homo sapiens 69-104 33411826-2 2021 Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group. Folic Acid 24-34 methylenetetrahydrofolate reductase Homo sapiens 106-111 33411826-2 2021 Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group. Folic Acid 127-137 methylenetetrahydrofolate reductase Homo sapiens 69-104 33411826-2 2021 Dietary factors such as folic acid can affect epigenetic marks using methylenetetrahydrofolate reductase (MTHFR) to metabolize folic acid to a one-carbon methyl group. Folic Acid 127-137 methylenetetrahydrofolate reductase Homo sapiens 106-111 33411826-6 2021 Grouping the epigenetic modifying enzymes by function indicated that gene expression was widely affected for genes that code for enzymes affecting DNA methylation, histone acetylation, histone methylation, histone phosphorylation, and histone ubiquitination when excess folic acid treatment occurred with or without the knockdown of MTHFR. Folic Acid 270-280 methylenetetrahydrofolate reductase Homo sapiens 333-338 33411826-7 2021 MTHFR was significantly reduced upon excess folic acid treatment whether MTHFR was knocked-down or not. Folic Acid 44-54 methylenetetrahydrofolate reductase Homo sapiens 0-5 33411826-7 2021 MTHFR was significantly reduced upon excess folic acid treatment whether MTHFR was knocked-down or not. Folic Acid 44-54 methylenetetrahydrofolate reductase Homo sapiens 73-78 33411826-12 2021 Excess folic acid induced an increase in dendritic spines without the MTHFR knockdown, but folic acid induced a decrease in dendritic spines when MTHFR was knocked-down. Folic Acid 91-101 methylenetetrahydrofolate reductase Homo sapiens 146-151 33411826-14 2021 Histone 3 acetylation at lysine 18 was significantly increased when excess folic acid was applied to cells with the MTHFR knockdown, as was histone 3 phosphorylation at serine 10. Folic Acid 75-85 methylenetetrahydrofolate reductase Homo sapiens 116-121 33411826-15 2021 Broadly, our results indicate that excess folic acid, even with functioning MTHFR, could have detrimental effects on cells. Folic Acid 42-52 methylenetetrahydrofolate reductase Homo sapiens 76-81 33497043-0 2021 A Association of MTHFR C677T and MTRR A66G Gene Polymorphisms with Iranian Male Infertility and Its Effect on Seminal Folate and Vitamin B12. Folic Acid 118-124 methylenetetrahydrofolate reductase Homo sapiens 17-22 32098547-1 2021 Background: The methylene tetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme which catalyzes the conversion of homocysteine to methionine. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 33497043-2 2021 We aimed to determine whether 5, 10-methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase reductase (MTRR) A66G genotypes are associated with male infertility in Iranian men and to evaluate its effect on seminal levels of folate and vitamin B12. Folic Acid 55-61 methylenetetrahydrofolate reductase Homo sapiens 73-78 33426516-2 2021 Folate processing (Methylenetetrahydrofolate reductase, MTHFR) gene abnormalities are common in women with epilepsy and depression. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 19-54 33315905-3 2020 The MTHFR C677T variant influences folate metabolism and has been implicated in depression during pregnancy. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 4-9 33315905-5 2020 HYPOTHESIS: In the first three months postpartum, folate will moderate a relationship between MTHFR genotype and depression, with TT homozygous women having more symptoms than CC homozygous women. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 94-99 33315905-10 2020 DISCUSSION: These data suggest that perhaps there is a relationship between MTHFR C677T, folate level and some symptoms of postpartum psychopathology. Folic Acid 89-95 methylenetetrahydrofolate reductase Homo sapiens 76-81 33290257-1 2020 5,10-methylenetetrahydrofolate reductase (MTHFR) deficiency is a rare hereditary disease characterized by defects in folate and homocysteine metabolism. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 33290257-3 2020 MTHFR is a rate-limiting enzyme catalyzing folate production, various SNPs/mutations in the MTHFR gene have been correlated to MTHFR deficiency. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 0-5 33290257-3 2020 MTHFR is a rate-limiting enzyme catalyzing folate production, various SNPs/mutations in the MTHFR gene have been correlated to MTHFR deficiency. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 92-97 33290257-3 2020 MTHFR is a rate-limiting enzyme catalyzing folate production, various SNPs/mutations in the MTHFR gene have been correlated to MTHFR deficiency. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 92-97 33123371-3 2020 The gene for the enzyme 5,10-methylentetrahydrofolate reductase (MTHFR) contributes to folic acid metabolism, and polymorphisms of this gene at C677T (rs1801133) and A1298C (rs1801131) are reported to alter its enzyme activity and are suggested to be involved in CL/P development. Folic Acid 87-97 methylenetetrahydrofolate reductase Homo sapiens 24-63 33123371-3 2020 The gene for the enzyme 5,10-methylentetrahydrofolate reductase (MTHFR) contributes to folic acid metabolism, and polymorphisms of this gene at C677T (rs1801133) and A1298C (rs1801131) are reported to alter its enzyme activity and are suggested to be involved in CL/P development. Folic Acid 87-97 methylenetetrahydrofolate reductase Homo sapiens 65-70 32826232-0 2020 The Folate Cycle Enzyme MTHFR is a Critical Regulator of Cell Response to MYC-Targeting Therapies. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 24-29 32826232-3 2020 We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 94-99 32826232-3 2020 We establish that folate restriction and deficiency of the rate-limiting folate cycle enzyme, MTHFR - which exhibits reduced-function polymorphisms in about 10% of Caucasians - induce resistance to MYC targeting by BET and CDK7 inhibitors in cell lines, primary patient samples, and syngeneic mouse models of AML. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 94-99 33317014-2 2020 Maternal nutrient levels during pregnancy affect development, and methylene tetrahydrofolate reductase (MTHFR) is important for processing the nutrient folate. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 104-109 32188521-13 2020 In the subgroup analysis, MTHFR 677C>T modified the effect of folate status on homocysteine concentration. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 26-31 33717913-3 2021 Folate metabolism might be affected by Methylene Tetrahydrofolate Reductase (MTHFR) gene polymorphism. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 39-75 33717913-3 2021 Folate metabolism might be affected by Methylene Tetrahydrofolate Reductase (MTHFR) gene polymorphism. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 77-82 33168819-8 2020 Knockdown of MTHFD2 and MTHFR, two key enzymes in folate metabolism and methyl donor SAM production, significantly suppressed GC cell proliferation. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 24-29 33157923-1 2020 Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene can result in a reduced ability to utilize folic acid. Folic Acid 109-119 methylenetetrahydrofolate reductase Homo sapiens 17-52 33157923-1 2020 Mutations in the methylenetetrahydrofolate reductase (MTHFR) gene can result in a reduced ability to utilize folic acid. Folic Acid 109-119 methylenetetrahydrofolate reductase Homo sapiens 54-59 33157923-3 2020 This study aimed to evaluate the prevalence of the MTHFR 677C>T mutation among pregnant women in Yunnan Province so as to collect baseline data that may be utilized to guide folic acid supplementation efforts and to support related disease prevention programs. Folic Acid 174-184 methylenetetrahydrofolate reductase Homo sapiens 51-56 33426516-2 2021 Folate processing (Methylenetetrahydrofolate reductase, MTHFR) gene abnormalities are common in women with epilepsy and depression. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 56-61 32451826-1 2020 5,10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency is a rare, autosomal recessive, metabolic disorder of folate metabolism, which affects homocysteine remethylation. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 43-48 33121283-1 2020 Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL), the results of recent studies have been inconsistent. Folic Acid 59-69 methylenetetrahydrofolate reductase Homo sapiens 114-149 33121283-1 2020 Objective: Although genetic variants of key enzymes in the folic acid-methionine metabolic circulation, including methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) were thought to be related to the risk of recurrent pregnancy loss (RPL), the results of recent studies have been inconsistent. Folic Acid 59-69 methylenetetrahydrofolate reductase Homo sapiens 151-156 32887268-5 2020 Since 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in the biosynthesis of an active folate form, we evaluated the relevance of polymorphisms in the MTHFR gene on intracellular levels of bioactive metabolite, the 5-methyltetrahydrofolate (5-Me-THF). Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 48-53 32972375-2 2020 Methylenetetrahydrofolate reductase (MTHFR) has a significant role in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 32887268-5 2020 Since 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in the biosynthesis of an active folate form, we evaluated the relevance of polymorphisms in the MTHFR gene on intracellular levels of bioactive metabolite, the 5-methyltetrahydrofolate (5-Me-THF). Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 170-175 32410296-1 2020 BACKGROUND: Polymorphisms (rs1801133 or C677T; rs1801131 or A1298C) of the MTHFR gene and rs1801394 (A66G) of the MTRR gene are important genetic determinants of folate metabolism. Folic Acid 162-168 methylenetetrahydrofolate reductase Homo sapiens 75-80 32864099-5 2020 Higher doses of folic acid may be needed for patients with the T allele of MTHFR, so it may not be sufficient to give vitamin B12 (methylcobalamin) alone, even in countries with folate fortification. Folic Acid 16-26 methylenetetrahydrofolate reductase Homo sapiens 75-80 32404292-11 2020 T/T genotype of MTHFR modifies the relationship between folate and homocysteine. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 16-21 32379616-1 2020 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate metabolism in the process of one-carbon cycle and its deficiency results in elevated homocysteine concentration. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 32498709-2 2020 We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 109-114 32498709-2 2020 We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity. Folic Acid 133-139 methylenetetrahydrofolate reductase Homo sapiens 109-114 32498709-2 2020 We thus wished to determine whether the inefficiency in folate metabolism caused by genetic variation in the MTHFR and DHFR genes in folate metabolism, or inadequate folate intake, is associated with obesity. Folic Acid 133-139 methylenetetrahydrofolate reductase Homo sapiens 109-114 32318793-3 2020 The aim of this study was to explore whether polymorphisms of MTHFR and MTR influence arsenic methylation capacity and plasma folate and vitamin B12 levels and if these influences cause developmental delay in preschool children. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 62-67 32318793-9 2020 Subjects with the MTHFR C677T C/C genotype had significantly lower plasma folate and vitamin B12 levels than those with the MTHFR C677T C/T and T/T genotype. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 18-23 32203239-11 2020 DNA methylation of MTHFR, MTR, and MTRR was also significantly associated with folate treatment response (P < 0.001). Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 19-24 32549258-2 2020 Homocysteine (Hcy), a sulfur-aminoacid whose serum level is regulated by methylenetrahydrofolate reductase (MTHFR) activity and vitamin B12 and folate as cofactors, is a risk factor for inflammatory diseases. Folic Acid 90-96 methylenetetrahydrofolate reductase Homo sapiens 108-113 32334045-2 2020 Riboflavin (FAD) is a cofactor for methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate recycling, which generates methyl groups for homocysteine remethylation to methionine, the pre-cursor to the universal methyl donor S-adenosylmethionine (SAM). Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 72-77 31932513-5 2020 Over a median of 4.5 years, among those not receiving folic acid, participants with baseline serum B12 or serum folate above the median had a significantly lower risk of first ischemic stroke (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.57-0.96), especially in those with MTHFR 677 CC genotype (wild-type) (HR, 0.49; 95% CI, 0.31-0.78). Folic Acid 112-118 methylenetetrahydrofolate reductase Homo sapiens 285-290 32390395-4 2020 MTHFR is the key enzyme in folic acid metabolism, thus, it influences the production of the main donor of methyl groups for DNA methylation. Folic Acid 27-37 methylenetetrahydrofolate reductase Homo sapiens 0-5 32266834-5 2020 Results: The study demonstrates that the genetic variants in folate cycle and methionine cycle genes such as MTHFR, MTRR, MTR, BHMT and DNMT1 are associated with the risk of aneurysm. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 109-114 32340630-1 2020 BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) rs1801131 A/C variant results in a decrease in MTHFR enzymatic activity, which may play an important role in folate metabolism and is also an important source of DNA methylation and DNA synthesis. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 53-58 32340630-1 2020 BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) rs1801131 A/C variant results in a decrease in MTHFR enzymatic activity, which may play an important role in folate metabolism and is also an important source of DNA methylation and DNA synthesis. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 107-112 33544785-6 2020 Methylenetetrahydrofolate reductase (MTHFR) gene codes the enzyme involved in the intracellular metabolism of folic acid; the 677C-T polymorphism of this gene causes the thermolability of the enzyme and decreased enzymatic activity, which is also dependent of folate plasmatic level. Folic Acid 110-120 methylenetetrahydrofolate reductase Homo sapiens 0-35 33544785-6 2020 Methylenetetrahydrofolate reductase (MTHFR) gene codes the enzyme involved in the intracellular metabolism of folic acid; the 677C-T polymorphism of this gene causes the thermolability of the enzyme and decreased enzymatic activity, which is also dependent of folate plasmatic level. Folic Acid 110-120 methylenetetrahydrofolate reductase Homo sapiens 37-42 33544785-6 2020 Methylenetetrahydrofolate reductase (MTHFR) gene codes the enzyme involved in the intracellular metabolism of folic acid; the 677C-T polymorphism of this gene causes the thermolability of the enzyme and decreased enzymatic activity, which is also dependent of folate plasmatic level. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 31734877-1 2020 OBJECTIVE: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 48-53 32440179-1 2020 Purpose: Red blood cell (RBC) folate indicates long-term folate intake, and methylenetetrahydrofolate reductase (MTHFR) gene is the main gene affecting folate status. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 113-118 32440179-1 2020 Purpose: Red blood cell (RBC) folate indicates long-term folate intake, and methylenetetrahydrofolate reductase (MTHFR) gene is the main gene affecting folate status. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 113-118 32440179-11 2020 Conclusion: Higher RBC folate, partly caused by MTHFR 677C T, may be associated with increased GDM risk, even in early pregnancy. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 48-53 32440179-12 2020 Assessing RBC folate status and appropriately supplementing folate during early pregnancy, particularly for patients with MTHFR 677C T, may prevent GDM. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 122-127 32013623-1 2020 Purpose: To assess the associations between preeclampsia, methylenetetrahydrofolate reductase (MTHFR) C677T, and reduced folate carrier-1 (RFC-1) G80A gene polymorphism in Sudanese women.Methods: A matched (for age and parity) case-control study was conducted in a tertiary hospital (Saad Abualila) in Khartoum, Sudan during February to September 2018. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 95-100 32119787-1 2020 Purpose: The methylene tetrahydrofolate reductase (MTHFR) C677T, MTHFR A1298C, and the methionine synthase reductase (MTRR) A66G polymorphisms are the three most common folate metabolism-related loci in the Chinese population. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 51-56 31932513-6 2020 Folic acid treatment significantly reduced the risk of first ischemic stroke in participants with both folate and B12 below the median (2.3% in enalapril-folic acid group vs 3.6% in enalapril-only group; HR, 0.62; 95% CI, 0.46-0.86), particularly in MTHFR 677 CC carriers (1.6% vs 4.9%; HR, 0.24; 95% CI, 0.11-0.55). Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 250-255 31482954-1 2019 OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS). Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 98-103 31127676-0 2020 Effects of folic acid on oligozoospermia with MTHFR polymorphisms in term of seminal parameters, DNA fragmentation, and live birth rate: a double-blind, randomized, placebo-controlled trial. Folic Acid 11-21 methylenetetrahydrofolate reductase Homo sapiens 46-51 31127676-2 2020 However, there are few data concerning the influence of folic acid supplementation on male-factor infertility with MTHFR gene polymorphisms. Folic Acid 56-66 methylenetetrahydrofolate reductase Homo sapiens 115-120 31127676-3 2020 OBJECTIVES: To evaluate whether folic acid supplementation has a beneficial effect on oligozoospermia with MTHFR gene polymorphisms in Chinese infertility population. Folic Acid 32-42 methylenetetrahydrofolate reductase Homo sapiens 107-112 31127676-7 2020 RESULTS: Administration of folic acid for 3 months could significantly improve the seminal parameters in patients with MTHFR 677 TT genotype in comparison with that receiving placebo. Folic Acid 27-37 methylenetetrahydrofolate reductase Homo sapiens 119-124 31127676-9 2020 Spontaneous pregnancy rate and live birth rate tended to be significantly higher in couples in which the men with MTHFR 677 TT genotype receiving folic acid than that receiving placebo. Folic Acid 146-156 methylenetetrahydrofolate reductase Homo sapiens 114-119 31127676-12 2020 CONCLUSIONS: Folic acid supplementation has a beneficial effect on oligozoospermia with MTHFR 677 TT genotype in term of seminal parameters, seminal MDA, sperm DNA fragmentation, and pregnancy outcome. Folic Acid 13-23 methylenetetrahydrofolate reductase Homo sapiens 88-93 31739474-5 2019 Moreover, the variability of the methylenetetrahydrofolate reductase gene, important in both folate metabolism and migraine pathogenesis, modulates the beneficial effects of folate for migraines. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 33-68 32019154-0 2020 Food Intervention with Folate Reduces TNF-alpha and Interleukin Levels in Overweight and Obese Women with the MTHFR C677T Polymorphism: A Randomized Trial. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 110-115 31446167-1 2020 PURPOSE: Methyltetrahydrofolate reductase (MTHFR) C677T (ala222Val) is a single-nucleotide polymorphism (SNP) that affects the formation of 5-methyltetrahydrofolate (5-MTHF), the active folate that allows the recycling of homocysteine (Hcy) to Methionine. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 43-48 31968288-1 2020 Methylene tetrahydrofolate reductase (MTHFR) is a flavoprotein, involved in one-carbon pathway and is responsible for folate and homocysteine metabolism. Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 33081452-3 2020 Genetic variants of the polymorphism of the folate metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) 677C>T were determined using real-time PCR. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 69-104 33081452-3 2020 Genetic variants of the polymorphism of the folate metabolism enzyme methylenetetrahydrofolate reductase (MTHFR) 677C>T were determined using real-time PCR. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 106-111 31920364-3 2019 The aim of the study was to investigate the effect of folate metabolizing genes (MTHFR and DHFR) polymorphisms on different parameters of complete blood count in patients who were treated with carbamazepine and valproic acid. Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 81-86 31663297-1 2019 INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) is essential in mediating folate metabolism, and thus plays an important role in diabetes and diabetic complications. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 51-56 31740010-10 2019 This study supported the hypothesis that, in Thais, low folate status is associated with a higher risk of CRC, particularly among those with polymorphisms of the MTHFR 677C > T and MTR 2756 A > G genes. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 162-167 31401974-3 2019 MTHFR and several vitamins (as cofactors) are crucial for remethylation of homocysteine via folate and homocysteine metabolism. Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 0-5 31005971-0 2019 The MTHFR 677C>T polymorphism is associated with unmetabolized folic acid in breast milk in a cohort of Canadian women. Folic Acid 63-73 methylenetetrahydrofolate reductase Homo sapiens 4-9 31005971-9 2019 However, the MTHFR 677C>T SNP was associated with breast-milk UMFA (R2 = 0.01; unadjusted P = 0.004), explaining a small portion of total variance; this association remained significant when adjusted for other covariates, including supplemental folic acid consumption. Folic Acid 245-255 methylenetetrahydrofolate reductase Homo sapiens 13-18 31005971-12 2019 The association between the MTHFR 677C>T SNP and breast-milk UMFA, albeit modest, highlights the need to better understand the determinants of breast-milk folate and the impact they might have on milk folate bioavailability. Folic Acid 155-161 methylenetetrahydrofolate reductase Homo sapiens 28-33 31005971-12 2019 The association between the MTHFR 677C>T SNP and breast-milk UMFA, albeit modest, highlights the need to better understand the determinants of breast-milk folate and the impact they might have on milk folate bioavailability. Folic Acid 201-207 methylenetetrahydrofolate reductase Homo sapiens 28-33 31393794-10 2019 High-dose folic acid supplement treatment exacerbated hypomethylation in MTHFR 677TT men compared with 677CC. Folic Acid 10-20 methylenetetrahydrofolate reductase Homo sapiens 73-78 31155015-8 2019 Optimising B-vitamin intake may be particularly important for sub-populations with impaired folate metabolism owing to genetic characteristics, most notably the 677C T variant in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR). Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 208-243 31155015-8 2019 Optimising B-vitamin intake may be particularly important for sub-populations with impaired folate metabolism owing to genetic characteristics, most notably the 677C T variant in the gene encoding the enzyme methylenetetrahydrofolate reductase (MTHFR). Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 245-250 31155015-9 2019 This common folate polymorphism is linked with several adverse health outcomes, including stroke, however, recent evidence has identified its novel interaction with riboflavin (the MTHFR cofactor) in relation to blood pressure and risk of developing hypertension. Folic Acid 12-18 methylenetetrahydrofolate reductase Homo sapiens 181-186 31396477-1 2019 Background: Methylenetetrahydrofolate reductase (MTHFR) gene is a crucial regulator of folate metabolism and its two prominent polymorphic variants C677T and A1298C lead to decreased MTHFR enzyme activity. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 31396477-1 2019 Background: Methylenetetrahydrofolate reductase (MTHFR) gene is a crucial regulator of folate metabolism and its two prominent polymorphic variants C677T and A1298C lead to decreased MTHFR enzyme activity. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 183-188 30916789-4 2019 Inborn errors of folate metabolism include deficiencies of the enzymes methylenetetrahydrofolate reductase, dihydrofolate reductase and 5,10-methenyltetrahydrofolate synthetase. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 71-106 31482954-1 2019 OBJECTIVE: To investigate the association of the genetic variants of the folate metabolism genes (MTHFR C677T; MTHFR A1298C; MTR A2756G; MTRR A66G and RFC-1 A80G) with the development of polycystic ovary syndrome (PCOS). Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 111-116 31216671-0 2019 Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer. Folic Acid 15-21 methylenetetrahydrofolate reductase Homo sapiens 92-127 31200713-2 2019 The aim of this study is to explore the effects of folate pathway gene polymorphisms (the 5-10-methylenetetrahydrofolate reductase, MTHTR C677T, MTHFR A1298C and the methionine synthase reductase, MTRR A66G) and their interactions with homocysteine on serum lipid levels in patients with RSA. Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 145-150 31216671-0 2019 Association of Folate and Vitamins Involved in the 1-Carbon Cycle with Polymorphisms in the Methylenetetrahydrofolate Reductase Gene (MTHFR) and Global DNA Methylation in Patients with Colorectal Cancer. Folic Acid 15-21 methylenetetrahydrofolate reductase Homo sapiens 134-139 31216671-2 2019 Thus, the objective of this study was to evaluate the association of folate and vitamins involved in the 1-carbon cycle and MTHFR polymorphisms in global DNA methylation in patients with colorectal cancer gene. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 124-129 30941645-10 2019 MTHFR expression showed a strong positive correlation (r = 0.96, p < 0.01) with folate levels in placenta. Folic Acid 83-89 methylenetetrahydrofolate reductase Homo sapiens 0-5 31494266-7 2019 Moreover, significant genetic diversity in MTHFR, TCN2, FADS1, and FADS2, which associate with circulating folate, vitamin B12, or lipid metabolism, was observed between northerners and southerners. Folic Acid 107-113 methylenetetrahydrofolate reductase Homo sapiens 43-48 30862944-0 2019 Regulation of folate and methionine metabolism by multisite phosphorylation of human methylenetetrahydrofolate reductase. Folic Acid 14-20 methylenetetrahydrofolate reductase Homo sapiens 85-120 31143237-0 2019 The MTHFR C677T polymorphism influences the efficacy of folic acid supplementation on the nerve conduction studies in patients with diabetic polyneuropathy; A randomized, double blind, placebo-controlled study. Folic Acid 56-66 methylenetetrahydrofolate reductase Homo sapiens 4-9 31143237-1 2019 Background: Among patients with diabetic polyneuropathy, the status of folic acid, homocysteine, and nerve conduction studies (NCS) variations has been associated with methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. Folic Acid 71-81 methylenetetrahydrofolate reductase Homo sapiens 168-203 31143237-1 2019 Background: Among patients with diabetic polyneuropathy, the status of folic acid, homocysteine, and nerve conduction studies (NCS) variations has been associated with methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. Folic Acid 71-81 methylenetetrahydrofolate reductase Homo sapiens 205-210 31143237-8 2019 Results: Four months after intervention, patients significantly observed change of serum folic acid and homocysteine levels based on C677T genotypes in the MTHFR gene. Folic Acid 89-99 methylenetetrahydrofolate reductase Homo sapiens 156-161 31143237-12 2019 Conclusion: The study determined that MTHFR C677T polymorphism effects the efficacy of folic acid supplementation on serum folic acid, homocysteine levels and some NCS parameters in diabetic polyneuropathy patients. Folic Acid 87-97 methylenetetrahydrofolate reductase Homo sapiens 38-43 31143237-12 2019 Conclusion: The study determined that MTHFR C677T polymorphism effects the efficacy of folic acid supplementation on serum folic acid, homocysteine levels and some NCS parameters in diabetic polyneuropathy patients. Folic Acid 123-133 methylenetetrahydrofolate reductase Homo sapiens 38-43 30529100-1 2019 MTHFR is a key enzyme in folate metabolism. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 0-5 30848279-2 2019 A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 200-235 30350398-6 2018 CONCLUSIONS: The effects of supplementation with folic acid + vitamin B12 and MOF on DNA methylation age are dependent upon gender and MTHFR genotype. Folic Acid 49-59 methylenetetrahydrofolate reductase Homo sapiens 135-140 30606816-9 2019 MTHFR-C677T altered protein turnover and folate mediated 1-carbon metabolic fluxes in lymphoblasts with and without MTX. Folic Acid 41-47 methylenetetrahydrofolate reductase Homo sapiens 0-5 30053573-4 2019 Polymorphisms in the Methyltetrahydrofolate Reductase (MTHFR) encoding gene, such as A1298C and C667T, are associated with the decreased bioavailability of folate, and this condition can act like folate deficiency. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 55-60 30080444-1 2019 One-carbon metabolism provides a direct link among dietary folate/vitamin B12 exposure, the activity of the enzyme methylenetetrahydrofolate reductase (MTHFR), and epigenetic regulation of the genome via DNA methylation. Folic Acid 59-65 methylenetetrahydrofolate reductase Homo sapiens 115-150 30080444-1 2019 One-carbon metabolism provides a direct link among dietary folate/vitamin B12 exposure, the activity of the enzyme methylenetetrahydrofolate reductase (MTHFR), and epigenetic regulation of the genome via DNA methylation. Folic Acid 59-65 methylenetetrahydrofolate reductase Homo sapiens 152-157 30080444-2 2019 Previously, it has been shown that the common c.677C > T polymorphism in MTHFR influences global DNA methylation status through a direct interaction with folate status and (indirectly) with total homocysteine (tHcy) levels. Folic Acid 157-163 methylenetetrahydrofolate reductase Homo sapiens 76-81 31902858-2 2019 Folate and vitamin B12 are key elements of the one-carbon metabolism pathway where methylenetetrahydrofolate reductase (MTHFR) plays a significant role. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 83-118 31902858-2 2019 Folate and vitamin B12 are key elements of the one-carbon metabolism pathway where methylenetetrahydrofolate reductase (MTHFR) plays a significant role. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 120-125 31902858-4 2019 By reviewing the relevant literatures and summarizing the potential effect of dietary folate intake on MTHFR genes polymorphism and breast cancer risk, we conclude that MTHFR C677T gene polymorphism is associated with breast cancer risk among Asian, but not Caucasians, and the MTHFR A1298C gene polymorphism is not a susceptibility factor of breast cancers. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 103-108 31902858-4 2019 By reviewing the relevant literatures and summarizing the potential effect of dietary folate intake on MTHFR genes polymorphism and breast cancer risk, we conclude that MTHFR C677T gene polymorphism is associated with breast cancer risk among Asian, but not Caucasians, and the MTHFR A1298C gene polymorphism is not a susceptibility factor of breast cancers. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 169-174 31902858-4 2019 By reviewing the relevant literatures and summarizing the potential effect of dietary folate intake on MTHFR genes polymorphism and breast cancer risk, we conclude that MTHFR C677T gene polymorphism is associated with breast cancer risk among Asian, but not Caucasians, and the MTHFR A1298C gene polymorphism is not a susceptibility factor of breast cancers. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 169-174 31902858-5 2019 Concomitant low activity of MTHFR enzyme resulted from C677T gene polymorphism and low dietary folate intake is associated with increased breast cancer risk. Folic Acid 95-101 methylenetetrahydrofolate reductase Homo sapiens 28-33 30633186-1 2019 RATIONALE: Hereditary hyperhomocysteinemia results from a polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene that reduces folate metabolism. Folic Acid 97-103 methylenetetrahydrofolate reductase Homo sapiens 115-120 30397195-1 2018 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for the critical process of one-carbon metabolism involving folate and homocysteine metabolisms. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 30397195-4 2018 It is also understudied on whether folate supplements could be an effective treatment for psychiatric patients with defect MTHFR activity. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 123-128 30397195-5 2018 In this review, we not only gathered the most recent discoveries on MTHFR polymorphism and related DNA methylation in various psychiatric disorders, but also highlighted the potential relationships between MTHFR activity and implication of folate-related function in specific mental diseases. Folic Acid 240-246 methylenetetrahydrofolate reductase Homo sapiens 68-73 30397195-5 2018 In this review, we not only gathered the most recent discoveries on MTHFR polymorphism and related DNA methylation in various psychiatric disorders, but also highlighted the potential relationships between MTHFR activity and implication of folate-related function in specific mental diseases. Folic Acid 240-246 methylenetetrahydrofolate reductase Homo sapiens 206-211 29702041-0 2018 Influence of the C677T Polymorphism of the MTHFR Gene on Oxidative Stress in Women With Overweight or Obesity: Response to a Dietary Folate Intervention. Folic Acid 133-139 methylenetetrahydrofolate reductase Homo sapiens 43-48 29702041-1 2018 The C677T polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) is related to folate metabolism and can alter the levels of biochemical markers. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 72-77 29702041-2 2018 OBJECTIVE: Investigate the influence of the MTHFR C677T polymorphism on the effects of a dietary folate intervention on oxidative stress in women with overweight or obesity. Folic Acid 97-103 methylenetetrahydrofolate reductase Homo sapiens 44-49 29702041-7 2018 CONCLUSIONS: The study demonstrated the beneficial effect of folate intake in terms of a TAC elevation for the CC and TT genotypes of the MTHFR C677T polymorphism, an increase in folic acid levels for all genotypes, and a reduction in the Hcy levels for the TT genotype in response to an intervention consisting of an intake of 191 microg/d of folate supplied by vegetables. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 138-143 29702041-7 2018 CONCLUSIONS: The study demonstrated the beneficial effect of folate intake in terms of a TAC elevation for the CC and TT genotypes of the MTHFR C677T polymorphism, an increase in folic acid levels for all genotypes, and a reduction in the Hcy levels for the TT genotype in response to an intervention consisting of an intake of 191 microg/d of folate supplied by vegetables. Folic Acid 344-350 methylenetetrahydrofolate reductase Homo sapiens 138-143 29953918-2 2018 Some loci and genes that are associated with folate levels had been detected by genome-wide association studies (GWAS), such as rs1801133 in MTHFR and rs1979277 in SHMT1. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 141-146 29953918-7 2018 RESULTS: We validated that rs1801133 in MTHFR was significantly involved in serum folate (P = 4.21 x 10-19). Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 40-45 30631824-2 2019 Moreover, methylenetetrahydrofolate reductase (MTHFR) constitutes the primary enzyme of the folate pathway. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 47-52 30451038-3 2019 The MTHFR gene is one of the few replicated genetic risk factors for migraine and encodes an enzyme that is crucial for the folate and the methionine cycles. Folic Acid 124-130 methylenetetrahydrofolate reductase Homo sapiens 4-9 30468411-1 2019 AIM: 5,10-MTHFR-single nucleotide polymorphisms are important for normal functioning of the enzyme that plays a key role in DNA synthesis, folate metabolism and methylation reactions. Folic Acid 139-145 methylenetetrahydrofolate reductase Homo sapiens 10-15 30339177-0 2018 The 677C T variant of MTHFR is the major genetic modifier of biomarkers of folate status in a young, healthy Irish population. Folic Acid 75-81 methylenetetrahydrofolate reductase Homo sapiens 22-27 30339177-4 2018 Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 55-60 30339177-4 2018 Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations. Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 13-53 30339177-4 2018 Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations. Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 55-60 30339177-4 2018 Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations. Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 13-53 30339177-4 2018 Results: The 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C T (rs1801133) variant was the major genetic modifier of all 3 folate-related biomarkers in this Irish population and reached genome-wide significance for red blood cell folate (P = 1.37 x 10-17), serum folate (P = 2.82 x 10-11), and plasma total homocysteine (P = 1.26 x 10-19) concentrations. Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 55-60 30339177-9 2018 Conclusions: The MTHFR 677C T variant is the predominant genetic modifier of folate status biomarkers in this healthy Irish population. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 17-22 30372582-0 2018 The modifying effect of the MTHFR genotype on the association between folic acid supplementation and pulse wave velocity: Findings from the CSPPT. Folic Acid 70-80 methylenetetrahydrofolate reductase Homo sapiens 28-33 30372582-8 2018 The positive effect of folic acid on improved PWV was modified by the MTHFR genotype (P for interaction = 0.034). Folic Acid 23-33 methylenetetrahydrofolate reductase Homo sapiens 70-75 30401001-5 2018 The degree of tHcy reduction associated with long-term folic acid supplementation can be significantly affected by sex, MTHFR C677T genotypes, baseline folate, tHcy, eGFR levels and smoking status. Folic Acid 55-65 methylenetetrahydrofolate reductase Homo sapiens 120-125 30578914-7 2018 Notably, defective variants in MTHFR and RBP4, two genes involved in folic acid and vitamin A biosynthesis, were found to have high contributions to NSCL/P incidence based on feature importance evaluation with logistic regression. Folic Acid 69-79 methylenetetrahydrofolate reductase Homo sapiens 31-36 29803102-5 2018 The accuracy was evaluated by assessing the polymorphisms of methylenetetrahydrofolate reductase (MTHFR) C677T and aldehyde dehydrogenase-2 (ALDH2) Glu504Lys, which are better known for their critical role in folate and ethanol metabolism, respectively. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 98-103 30198140-6 2018 Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer. Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 26-31 29882091-2 2018 PURPOSE: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid. Folic Acid 230-240 methylenetetrahydrofolate reductase Homo sapiens 99-136 30120883-3 2018 This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India. Folic Acid 71-77 methylenetetrahydrofolate reductase Homo sapiens 175-210 30120883-3 2018 This study aims to evaluate the association between genetic defects in folate metabolism pathway genes, mainly: Folate hydrolase 1 (FOLH1), Dihydrofolate reductase (DHFR) and Methylenetetrahydrofolate reductase (MTHFR) and neural tube defects from eastern India. Folic Acid 71-77 methylenetetrahydrofolate reductase Homo sapiens 212-217 29796841-1 2018 OBJECTIVES: The study investigated the association between plasma homocysteine, folate and vitamin B12 with 5,10 methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), thymidylate synthase (TYMS 2R 3R) and methionine synthase (MTR A2756G) polymorphisms and methotrexate (MTX) treatment and toxicity in Tunisian Rheumatoid arthritis (RA) patients. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 150-155 29882091-2 2018 PURPOSE: To evaluate the possibility of correcting metabolic defects in gametes and embryos due to methylene tetra hydrofolate reductase (MTHFR) isoforms C677T and A1298C, by supplementation with 5-methyl THF instead of synthetic folic acid. Folic Acid 230-240 methylenetetrahydrofolate reductase Homo sapiens 138-143 30061759-1 2018 Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 79-84 29524840-1 2018 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism and plays a central role in DNA methylation and biosynthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 29524840-2 2018 MTHFR mutations may alter the cellular folate supply which in turn affects nucleic acid synthesis, DNA methylation and chromosomal damage. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 0-5 30061759-1 2018 Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 106-141 30061759-1 2018 Background: The gene for 5,10-methylenetetrahydrofolate reductase (NAD(P)H) or MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme important in folate metabolism. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 143-148 29360980-2 2018 We recently detected an unexpected loss of DNA methylation in the sperm of idiopathic infertile men after 6 months of daily supplementation with 5 mg folic acid (>10x the daily recommended intake-DRI), exacerbated in men homozygous for a common variant in the gene encoding an important enzyme in folate metabolism, methylenetetrahydrofolate reductase (MTHFR 677C>T). Folic Acid 150-160 methylenetetrahydrofolate reductase Homo sapiens 319-354 29185200-1 2018 BACKGROUND: Methylenetetrahyfrofolate reductase (MTHFR) is the key enzyme for one carbon and folate metabolism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 30158810-1 2018 Aim: This study aimed to understand the association of gene-specific methylation of the promoter region of methylenetetrahydrofolate reductase (MTHFR) in the causation of recurrent miscarriages (RMs) both independently and also in light of MTHFR C677T polymorphism, hyperhomocysteinemia, folate, and Vitamin B12 deficiency. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 144-149 30158810-1 2018 Aim: This study aimed to understand the association of gene-specific methylation of the promoter region of methylenetetrahydrofolate reductase (MTHFR) in the causation of recurrent miscarriages (RMs) both independently and also in light of MTHFR C677T polymorphism, hyperhomocysteinemia, folate, and Vitamin B12 deficiency. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 240-245 29427165-1 2018 Polymorphisms in MTHFR gene are mostly associated with increased levels of homocysteine in the absence of dietary folate and are a risk factor for complex neurovascular diseases like migraine. Folic Acid 114-120 methylenetetrahydrofolate reductase Homo sapiens 17-22 29564022-13 2018 This may be due to small sample sizes or folate repletion in our Canadian population attenuating effects of the high-risk MTHFR variants. Folic Acid 41-47 methylenetetrahydrofolate reductase Homo sapiens 122-127 29371246-8 2018 Our data raised the prospect to tailor folic acid therapy according to individual MTHFR C677T genotype and folate status. Folic Acid 39-49 methylenetetrahydrofolate reductase Homo sapiens 82-87 28004270-10 2018 Homozygous (T/T) or heterozygous (C/T) women for MTHFR-C677T had lower plasma folate concentrations [C/T: -6.48% (p value = 0.038) and T/T: -15.89% (p value <0.001)] compared to women carrying the C/C genotype. Folic Acid 78-84 methylenetetrahydrofolate reductase Homo sapiens 49-54 29474406-11 2018 Further, the V allele of the A222V SNP and the E allele of the E429A SNP in methylene tetrahydrofolate reductase (MTHFR) were associated with low RBC folate levels. Folic Acid 96-102 methylenetetrahydrofolate reductase Homo sapiens 114-119 29162511-4 2018 METHODS: We investigated if major polymorphisms of folate-related genes, namely MTHFR c.677C>T, MTR c.2756A>G, MTRR c.66A>G and TYMS TSER (a 28-bp tandem repeat in the 5" promoter enhancer region of TYMS) increase the risk of pathological changes of the thymus in AChR+ MG patients. Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 80-85 29371246-0 2018 MTHFR Gene and Serum Folate Interaction on Serum Homocysteine Lowering: Prospect for Precision Folic Acid Treatment. Folic Acid 95-105 methylenetetrahydrofolate reductase Homo sapiens 0-5 29903290-13 2018 CONCLUSION: The present Meta-analysis suggests that MTHFR C677T is significantly associated with maternal risk for NTDs in the Chinese population, supplemental folic acid supplementation based on MTHFR polymorphisms will be an important means to further reduce the birth defects of newborns. Folic Acid 160-170 methylenetetrahydrofolate reductase Homo sapiens 52-57 29903290-13 2018 CONCLUSION: The present Meta-analysis suggests that MTHFR C677T is significantly associated with maternal risk for NTDs in the Chinese population, supplemental folic acid supplementation based on MTHFR polymorphisms will be an important means to further reduce the birth defects of newborns. Folic Acid 160-170 methylenetetrahydrofolate reductase Homo sapiens 196-201 29117460-1 2018 BACKGROUND: Folic acid supplement use during pregnancy might affect childhood respiratory health, potentially mediated by methylenetetrahydrofolate reductase polymorphism C677T (MTHFR-C677T) carriership. Folic Acid 12-22 methylenetetrahydrofolate reductase Homo sapiens 122-157 29360980-2 2018 We recently detected an unexpected loss of DNA methylation in the sperm of idiopathic infertile men after 6 months of daily supplementation with 5 mg folic acid (>10x the daily recommended intake-DRI), exacerbated in men homozygous for a common variant in the gene encoding an important enzyme in folate metabolism, methylenetetrahydrofolate reductase (MTHFR 677C>T). Folic Acid 150-160 methylenetetrahydrofolate reductase Homo sapiens 356-361 29222906-2 2018 In a case-control study we investigated C677T polymorphism in the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene in case and control mothers of Pakistani origin, and compared these with the respective maternal folate concentrations measured at the time of delivery. Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 109-114 29737822-0 2018 Effects of MTHFR A1298C polymorphism on peripheral blood folate concentration in healthy populations: a meta-analysis of observational studies. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 11-16 29737822-1 2018 BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) irreversibly converts 5,10- methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is the main form of folate used in the body. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 64-69 29737822-2 2018 Previous studies suggest that MTHFR polymorphism influences folate metabolism, but conflicting results are reported. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 30-35 29737822-3 2018 We performed a meta-analysis to accurately characterize the association between MTHFR A1298C polymorphism and peripheral blood folate concentration in healthy populations. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 80-85 29737822-7 2018 Significant differences in folate concentration were found in the MTHFR homozygote model (SMD=0.12, 95% CI=0.00-0.24, I2=17%, p=0.04) and the dominant model (SMD=0.07, 95% CI=0.01-0.14, I2=22%, p=0.02) in the general population excluding the elderly. Folic Acid 27-33 methylenetetrahydrofolate reductase Homo sapiens 66-71 29737822-9 2018 CONCLUSIONS: This meta-analysis indicates that, in the general population excluding the elderly, the C allele of MTHFR 1298 polymorphism is associated with the risk for an increased folate concentration. Folic Acid 182-188 methylenetetrahydrofolate reductase Homo sapiens 113-118 29461227-3 2018 Polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) is a genetic determinant of folate metabolism violation. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 67-72 29461227-14 2018 It includes determining the level of homocysteine and the MTHFR polymorphisms (in the case of hyperhomocysteinemia), which will identify the required dose of folic acid. Folic Acid 158-168 methylenetetrahydrofolate reductase Homo sapiens 58-63 28374953-1 2018 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR; NM_005957.4) is the key enzyme for folate metabolism which plays in DNA biosynthesis and the epigenetic process of DNA methylation. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 29865064-10 2018 Deregulation of AbetaPP provides a novel mechanism by which common human MTHFR polymorphisms may interact with dietary folate deficiency to alter neuronal homeostasis and increase the risk for sporadic AD. Folic Acid 119-125 methylenetetrahydrofolate reductase Homo sapiens 73-78 28984369-7 2018 Very high levels of maternal plasma folate at birth (>=60.3 nmol/L) had 2.5 times increased risk of ASD [95% confidence interval (CI) 1.3, 4.6] compared to folate levels in the middle 80th percentile, after adjusting for covariates including MTHFR genotype. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 245-250 30592864-0 2018 [Assessment of the sufficiency of Moscow population with folic acid, depending on the combined effect of polymorphism of MTHFR and FTO genes]. Folic Acid 57-67 methylenetetrahydrofolate reductase Homo sapiens 121-126 30592864-1 2018 The results of assessing the sufficiency of folic acid of the residents of the Moscow region have been presented depending on rs1801133 MTHFR gene polymorphism and rs9939609 FTO gene polymorphism. Folic Acid 44-54 methylenetetrahydrofolate reductase Homo sapiens 136-141 29246599-1 2017 BACKGROUND: Methylenetetrahydrofolate-reductase (MTHFR) deficiency is a rare autosomal recessive disorder affecting intracellular folate metabolism with affection of different organ systems and clinical manifestation usually in childhood. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 29545912-1 2018 5,10-Methylenetrahydrofolate reductase (MTHFR), a key enzyme for folate metabolism, catalyses the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, which is located at the end of the short arm (1p36.3). Folic Acid 22-28 methylenetetrahydrofolate reductase Homo sapiens 40-45 29340279-2 2017 Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are the two key regulatory enzymes in the folate/homocysteine (Hcy) metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 29951428-12 2017 Conclusion: MTHFR genotype, independent of folate availability and probable confounding parameters, might be a potential risk factor of perceived stress among nurses. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 12-17 28703660-8 2017 Conclusion Treatment with low-dose aspirin, enoxaparin and folic acid was the most effective therapy in women with RM who carried a C677T MTHFR mutation. Folic Acid 59-69 methylenetetrahydrofolate reductase Homo sapiens 138-143 29390492-2 2017 Functional variants of the methylenetetrahydrofolate reductase (MTHFR) gene result in disturbance in folate metabolism and may affect susceptibility to cancer. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 64-69 28778973-3 2017 We investigated the association between folic acid supplementation during pregnancy and loss of imprinting (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype. Folic Acid 40-50 methylenetetrahydrofolate reductase Homo sapiens 212-247 28778973-3 2017 We investigated the association between folic acid supplementation during pregnancy and loss of imprinting (LOI) of IGF2 and H19 genes in placentas and cord blood of 90 mother-child dyads in association with the methylenetetrahydrofolate reductase (MTHFR) genotype. Folic Acid 40-50 methylenetetrahydrofolate reductase Homo sapiens 249-254 29209581-7 2017 MTHFR A1298C is implicated in irregular homocysteine metabolism and aberrant folate cycles and, through this, it may play a role as either a driver in the development of MDD or as a predictive or diagnostic marker, possibly in combination with C677T. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 0-5 28820331-1 2017 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the folate cycle and its genetic variations have been associated with various human diseases. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 29259859-2 2017 Methylene Tetrahydrofolate Reductase (MTHFR) is one of the major enzymes of the folate metabolism pathway. Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 29259859-10 2017 MTHFR promoter methylation affects folate metabolism which is known to play a role in chromosomal breakage, abnormal chromosomal segregation and genomic instability and therefore a developmental defect in the form of congenital cardiac anomaly. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 0-5 29062171-1 2017 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate pathway. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 28598562-5 2017 Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T. Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 144-149 29026722-1 2017 OBJECTIVE: To identify the associations between polymorphisms of the 3"-untranslated region (UTR) of methylenetetrahydrofolate reductase (MTHFR) gene, which codes for an important regulatory enzyme primarily involved in folate metabolism, and idiopathic recurrent pregnancy loss (RPL) in Korean women. Folic Acid 120-126 methylenetetrahydrofolate reductase Homo sapiens 138-143 29026722-6 2017 Analysis of variance revealed that MTHFR 4869C>G was associated with altered CD56+ natural killer cell percentages (CC, 17.91%+-8.04%; CG, 12.67%+-4.64%; p=0.024) and folate levels (CC, 12.01+-7.18 mg/mL; CG, 22.15+-26.25 mg/mL; p=0.006). Folic Acid 170-176 methylenetetrahydrofolate reductase Homo sapiens 35-40 28689805-0 2017 The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 141-146 28598562-5 2017 Serum folate and total Hcy (tHcy) levels are influenced by folate intake and genetic polymorphisms in 5,10-methylenetertahydrofolate reductase (MTHFR) such as C677T. Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 102-142 28598562-10 2017 Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 55-60 28598562-10 2017 Accordingly, in this review, we discuss the effects of MTHFR C677T polymorphisms on serum tHcy and folate levels with folic acid intervention and evaluate approaches for overcoming folic acid deficiency and related symptoms. Folic Acid 118-128 methylenetetrahydrofolate reductase Homo sapiens 55-60 28534241-3 2017 Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes. Folic Acid 59-65 methylenetetrahydrofolate reductase Homo sapiens 126-161 26991917-9 2017 Our data suggest a protective effect in participants with MTHFR TT genotype and low folate levels. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 58-63 28534241-3 2017 Genome-wide association studies (GWAS) revealed that human folate level could be significantly influenced by fidgetin (FIGN), methylenetetrahydrofolate reductase (MTHFR), prickle homolog 2 (PRICKLE2), synaptotagmin 9 (SYT9), gamma-aminobutyric acid B receptor 2 (GABBR2), and alkaline phosphatase (ALPL) genes. Folic Acid 59-65 methylenetetrahydrofolate reductase Homo sapiens 163-168 28915669-7 2017 In conclusion, our meta-analysis suggests that two folate metabolism genetic variants MTRR A66G (rs1801394) and MTHFR A1298C (rs1801131) contribute to genetic susceptibility to meningioma and glioma in adults. Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 112-117 27774577-2 2017 Folate is a methyl donor during DNA methylation, as it provides substrate for methylenetetrahydrofolate reductase (MTHFR) to convert 5,10-MTHF to 5-MTHF and subsequently metabolizes it to methionine. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 115-120 28811683-1 2017 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme of folate pathway and required for DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 28440964-1 2017 The methylenetetrahydrofolate reductase (MTHFR) gene codes a crucial enzyme which involve in folate metabolism. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 28440964-9 2017 Also, we observed critical effect of vitamin B9 and B12 intake on decreasing of total homocysteine and improving of semen parameters among the men with T allele of MTHFR C677T polymorphism. Folic Acid 37-47 methylenetetrahydrofolate reductase Homo sapiens 164-169 27774577-2 2017 Folate is a methyl donor during DNA methylation, as it provides substrate for methylenetetrahydrofolate reductase (MTHFR) to convert 5,10-MTHF to 5-MTHF and subsequently metabolizes it to methionine. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 78-113 28587068-8 2017 The homocysteine concentrations increased in the CT and TT compared to CC genotypes of polymorphism MTHFR 677C>T in all populations, and differences between the homocysteine concentrations according to the genotypes of MTHFR 677C>T were observed regardless of folate level. Folic Acid 266-272 methylenetetrahydrofolate reductase Homo sapiens 100-105 28398657-2 2017 METHODS: We evaluated nutrient intake using 24-hr recall, assessing the levels of serum folate, RBC folate, serum B12 , and homocysteine, as well as determining genetic variants of the enzyme MTHFR (C677T and A1298C) and CbetaS (844ins68pb). Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 192-197 28544525-8 2017 Also, MTHFR gene A1298C polymorphism in the partial folate supplementation group showed a relationship with decreased MTX efficacy (CCvs. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 6-11 28277784-3 2017 Methylene tetrahydrofolate reductase (MTHFR) is an important enzyme in the MTX pathway and is involved in folate metabolism and DNA synthesis. Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 28277784-9 2017 In addition, RA patients with the MTHFR C677T polymorphism who were supplemented with folic acid displayed significantly elevated risk for MTX toxicity. Folic Acid 86-96 methylenetetrahydrofolate reductase Homo sapiens 34-39 28702146-1 2017 BACKGROUND: The 5, 10-methyleneterahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) are two essential enzymes involved in folate metabolism. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 58-63 28400561-0 2017 A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 95-100 28862175-1 2017 BACKGROUND & OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate metabolism, whose role in schizophrenia is debatable. Folic Acid 48-54 methylenetetrahydrofolate reductase Homo sapiens 66-71 27771938-7 2017 CONCLUSIONS: Data provide strong evidence that surface UV-irradiance reduces long-term systemic folate levels, and that this is influenced by the C677T-MTHFR gene variant. Folic Acid 96-102 methylenetetrahydrofolate reductase Homo sapiens 152-157 27771938-8 2017 We speculate this effect may be due to 677TT-MTHFR individuals containing more 5,10CH2 -H4 PteGlu, and that this folate form may be particularly UV labile. Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 45-50 28094233-2 2017 In this study, the combined effects of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and folate and vitamin B12 deficiency on serum total Hcy (tHcy) levels were evaluated in a healthy Chinese population in Yunnan Province, China. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 76-81 28094233-13 2017 Thus, folic acid and vitamin B12 supplementation could help prevent diseases associated with tHcy accumulation, especially in individuals with the MTHFR 677TT genotype. Folic Acid 6-16 methylenetetrahydrofolate reductase Homo sapiens 147-152 26820674-1 2017 Methylenetetrahydrofolate reductase (MTHFR) is key enzyme of folate/homocysteine pathway. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 26497154-0 2017 The impact of MTHFR 677 C/T genotypes on folate status markers: a meta-analysis of folic acid intervention studies. Folic Acid 41-47 methylenetetrahydrofolate reductase Homo sapiens 14-19 26497154-1 2017 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 26497154-1 2017 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 110-115 26497154-1 2017 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 9-44 26497154-1 2017 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 46-51 26497154-1 2017 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme with the T variant of the MTHFR gene increasing the risk of low folate status, particularly coupled with low folate intake. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 110-115 27759072-8 2017 In contrast, high folate concentrations attenuated the effects of the MTHFR C677T genotype on serum Hcy concentrations (P-value for interaction <0.001). Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 70-75 27759072-9 2017 Also, among males, blood folate concentration was the only lifestyle variable able to modify the influence of MTHFR A1298C genotypes on Hcy concentrations (P-value for the interaction <0.001). Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 110-115 27759072-11 2017 CONCLUSIONS: In summary, our study demonstrates a sex difference in Hcy concentrations among Brazilian young adults regarding MTHFR C677T-lifestyle interactions that are worsened under conditions of low blood folate. Folic Acid 209-215 methylenetetrahydrofolate reductase Homo sapiens 126-131 27384413-10 2017 For example, the effect of MTHFR 1298C appeared to be different between those mothers below US RDA folate intake (RR = 0.98) versus those at or above US RDA folate intake (RR = 0.68), but the interaction was not statistically significant (interaction p = 0.27). Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 27-32 27384413-10 2017 For example, the effect of MTHFR 1298C appeared to be different between those mothers below US RDA folate intake (RR = 0.98) versus those at or above US RDA folate intake (RR = 0.68), but the interaction was not statistically significant (interaction p = 0.27). Folic Acid 157-163 methylenetetrahydrofolate reductase Homo sapiens 27-32 28138253-1 2017 Methylenetetrahydrofolate reductase (MTHFR) is a central enzyme involved in folate metabolism and plays an important role in DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 28685147-2 2017 The MTHFR enzyme acts in the folate metabolism, which is essential in methylation and synthesis of nucleic acids. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 4-9 28685147-3 2017 MTHFR C677T alters homocysteine levels and folate assimilation associated with DNA damage. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 0-5 28373541-5 2017 The alleles under natural selection at two of these loci [methylenetetrahydrofolate reductase (MTHFR) and EPAS1] are strongly associated with blood-related phenotypes, such as hemoglobin, homocysteine, and folate in Tibetans. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 95-100 28397480-1 2017 BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme of folic acid metabolism and the C677T mutation is associated with decreased enzyme activity. Folic Acid 78-88 methylenetetrahydrofolate reductase Homo sapiens 12-48 28397480-1 2017 BACKGROUND: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme of folic acid metabolism and the C677T mutation is associated with decreased enzyme activity. Folic Acid 78-88 methylenetetrahydrofolate reductase Homo sapiens 50-55 26497154-2 2017 As genetic variability of MTHFR influences folate status, it is important to ensure an adequate intake that overrides genetic effects but minimises any adverse effects. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 26-31 26497154-6 2017 RESULTS: The MTHFR 677TT genotype was associated with higher plasma homocysteine (2.7 mumol/L, TT vs. CT/CC; 2.8 mumol/L, TT vs. CC) and lower serum folate (2.5 nmol/L, TT vs. CT/CC; 3.6 nmol/L, TT vs. CC). Folic Acid 149-155 methylenetetrahydrofolate reductase Homo sapiens 13-18 26497154-10 2017 CONCLUSIONS: This meta-analysis confirms observations from observational and intervention studies that MTHFR TT genotype is associated with increased plasma homocysteine and lowered serum folate and less response to short-term supplementation. Folic Acid 188-194 methylenetetrahydrofolate reductase Homo sapiens 103-108 27755385-11 2017 CONCLUSION: MTHFR is important for regulating transmethylation processes and is involved in regulation of folate metabolism. Folic Acid 106-112 methylenetetrahydrofolate reductase Homo sapiens 12-17 28081274-2 2016 Methylenetetrahydrofolate reductase (MTHFR) plays a vital role in folate metabolism, DNA methylation, and RNA synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 27783031-12 2016 Subjects with MTHFR 1793 G/A genotype along with low serum folate concentration demonstrated the lowest name and orientation abilities. Folic Acid 59-65 methylenetetrahydrofolate reductase Homo sapiens 14-19 27916838-2 2016 We hypothesized that genetic variants in methylenetetrahydrofolate reductase (MTHFR), a key enzyme of folate metabolism, would affect the prognosis of prostate cancer. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 78-83 28520345-2 2012 Genetic variations in the MTHFR gene can lead to impaired function or inactivation of this enzyme, which results in mildly elevated levels of homocysteine, especially in individuals who are also deficient in folate (1). Folic Acid 208-214 methylenetetrahydrofolate reductase Homo sapiens 26-31 27755291-1 2016 BACKGROUND: The rationale of the current study was to test the clinical utility of the folate pathway genetic polymorphisms in predicting the risk for autism spectrum disorders (ASD) and to address the inconsistencies in the association of MTHFR C677T and hyperhomocysteinemia with ASD. Folic Acid 87-93 methylenetetrahydrofolate reductase Homo sapiens 240-245 27605737-8 2016 In conclusion, this meta-analysis demonstrates a strong association between the MTHFR C677T variant and RPL in Asian population and raising the importance of the use of folate in its treatment and prevention. Folic Acid 169-175 methylenetetrahydrofolate reductase Homo sapiens 80-85 27130656-1 2016 The 5, 10 methylenetetrahydrofolate reductase (MTHFR) enzyme is a catalyst in the folate metabolism pathway, the byproducts of which are involved in the remethylation of homocysteine to methionine. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 47-52 27387868-1 2016 OBJECTIVE: The functional variant within the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene c.677C>T, producing alterations in folate metabolism, has been associated with the risk of non-syndromic cleft lip with or without cleft palate (NSCL/P). Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 87-92 27706773-1 2016 Activity of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, is influenced by mutations in the corresponding gene, contributing to a decrease in 5,10-MTHF. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 27649570-1 2016 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 27369467-3 2016 DNA methylation reactions rely on the cellular availability of methyl donors, which are primarily products of folate metabolism, where a key enzyme is methylenetetrahydrofolate reductase (MTHFR). Folic Acid 110-116 methylenetetrahydrofolate reductase Homo sapiens 151-186 27369467-3 2016 DNA methylation reactions rely on the cellular availability of methyl donors, which are primarily products of folate metabolism, where a key enzyme is methylenetetrahydrofolate reductase (MTHFR). Folic Acid 110-116 methylenetetrahydrofolate reductase Homo sapiens 188-193 26879954-1 2016 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) plays an important role in determining the proportions of folate coenzymes for DNA synthesis or DNA methylation. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 27585654-1 2016 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism is involved in DNA synthesis, DNA repair and DNA methylation. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 26559681-3 2016 The aim of our study was to explore the response of tHcy in hemodialysis (HD) patients to individual supplementation with folic acid (B9) and/or vitamin B12, based on carrier status for the (MTHFR) polymorphism. Folic Acid 122-132 methylenetetrahydrofolate reductase Homo sapiens 191-196 27708721-0 2016 The impact of MTHFR 677C T risk knowledge on changes in folate intake: findings from the Food4Me study. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 14-19 27363740-8 2016 The patient with MTHFR deficiency had extremely low 5MTHF and moderately low total folate; these values were not associated and showed no significant change after folic acid supplementation. Folic Acid 83-89 methylenetetrahydrofolate reductase Homo sapiens 17-22 27363740-8 2016 The patient with MTHFR deficiency had extremely low 5MTHF and moderately low total folate; these values were not associated and showed no significant change after folic acid supplementation. Folic Acid 163-173 methylenetetrahydrofolate reductase Homo sapiens 17-22 27659321-1 2016 Methylenetetrahydrofolate reductase (MTHFR) is the most important gene that participates in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 27520898-1 2016 The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a central role in folate metabolism. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 27173682-2 2016 C677T and A1298C MTHFR polymorphisms produce an enzyme with reduced folate-related one carbon metabolism, and this has been associated with aberrant methylation modifications in DNA and protein. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 17-22 27904604-0 2016 Evaluating the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (C677T and A1298C) gene polymorphisms in oral cleft children. Folic Acid 32-42 methylenetetrahydrofolate reductase Homo sapiens 87-122 27904604-1 2016 BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. Folic Acid 44-54 methylenetetrahydrofolate reductase Homo sapiens 99-134 27904604-1 2016 BACKGROUND: We studied the role of maternal folic acid supplementation in modifying the effects of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene polymorphisms in Iranian children with oral clefts. Folic Acid 44-54 methylenetetrahydrofolate reductase Homo sapiens 136-141 27478487-4 2016 The methylenetetrahydrofolate reductase (MTHFR) gene encodes for a 5-methylenetetrahydrofolate reductase involved in folate metabolism and neurotransmitter synthesis. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 27478487-4 2016 The methylenetetrahydrofolate reductase (MTHFR) gene encodes for a 5-methylenetetrahydrofolate reductase involved in folate metabolism and neurotransmitter synthesis. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 69-104 28149369-7 2016 The analysis of the alleles of the MTHFR C677T polymorphism showed that the participants that carried TT genotypes had a lower level of vitamin B12 and folate, and a higher level of Hcy than the participants carrying CC and CT genotypes. Folic Acid 152-158 methylenetetrahydrofolate reductase Homo sapiens 35-40 27187171-9 2016 A strong association between Hhcy and MTHFR TT genotype was observed (OR = 7.7, 95%CI:2.8-20.9) where all beta-TM patients with TT genotype were hyperhomocystienemic (>= 15 mumol/l) and having sub-optimal folate level than those with CT or CC genotypes. Folic Acid 208-214 methylenetetrahydrofolate reductase Homo sapiens 38-43 26961134-8 2016 Four DM CpGs identified by SNPs in MTRR, MTHFR, and FTHFD were significantly associated with alcohol consumption and/or breast folate. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 41-46 27068821-1 2016 MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive function. Folic Acid 50-60 methylenetetrahydrofolate reductase Homo sapiens 0-5 26879531-3 2016 As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias. Folic Acid 3-9 methylenetetrahydrofolate reductase Homo sapiens 73-108 27025471-1 2016 Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme of folate/homocysteine metabolic pathway. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 26879531-3 2016 As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias. Folic Acid 3-9 methylenetetrahydrofolate reductase Homo sapiens 110-115 26879531-3 2016 As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias. Folic Acid 204-214 methylenetetrahydrofolate reductase Homo sapiens 73-108 26879531-3 2016 As folate levels may also be influenced by the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, we hypothesize that a gene-environment interaction between this polymorphism and folic acid use is involved in the etiology of hypospadias. Folic Acid 204-214 methylenetetrahydrofolate reductase Homo sapiens 110-115 26687138-1 2016 PURPOSE: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism and plays a major role in DNA methylation. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 51-56 26438060-1 2016 The 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are critical enzymes in folate metabolism. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 26438060-3 2016 We investigated the risks of adult leukemia with genetic polymorphisms of folate metabolic enzymes (MTHFR C677T, A1298C, and TS) and evaluated if the associations varied by dietary folate intake from a multicenter case-control study conducted in Chinese. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 100-105 26438060-9 2016 Stratified analysis by dietary folate intake showed the increased risks of leukemia with the MTHFR 677TT and TS 2R3R/2R2R genotypes were only significant in individuals with low folate intake. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 93-98 26438060-9 2016 Stratified analysis by dietary folate intake showed the increased risks of leukemia with the MTHFR 677TT and TS 2R3R/2R2R genotypes were only significant in individuals with low folate intake. Folic Acid 178-184 methylenetetrahydrofolate reductase Homo sapiens 93-98 26438060-11 2016 This study suggests that dietary folate intake and gender may modify the associations between MTHFR/TS polymorphisms and adult leukemia risk. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 94-99 26111718-5 2016 Circulating folate and homocysteine levels as well as MTHFR genotype, while emerging as major predictors of the risk of vascular events and of the efficacy of folic acid therapy, have also proved to be determinants of an interindividual variability in the degree of lipid peroxidation and platelet activation, and of the extent of their downregulation by folic acid. Folic Acid 159-169 methylenetetrahydrofolate reductase Homo sapiens 54-59 26111718-5 2016 Circulating folate and homocysteine levels as well as MTHFR genotype, while emerging as major predictors of the risk of vascular events and of the efficacy of folic acid therapy, have also proved to be determinants of an interindividual variability in the degree of lipid peroxidation and platelet activation, and of the extent of their downregulation by folic acid. Folic Acid 355-365 methylenetetrahydrofolate reductase Homo sapiens 54-59 25412139-1 2016 The human methylenetetrahydrofolate reductase (MTHFR) gene encodes one of the key enzymes in folate metabolism. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 47-52 26806866-2 2016 Variants in the methylenetetrahydrofolate reductase gene (MTHFR), a gene encoding a folate-dependent enzyme that is involved in homocysteine metabolism, have been reported to be associated with PD. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 58-63 27014653-1 2016 BACKGROUND: Association between C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism and DNA methylation, and breast cancer risk are inconsistent. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 95-100 26218632-1 2016 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) gene encodes an essential enzyme involving in folate metabolism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 26218632-2 2016 Due to the role of folate in DNA integrity, polymorphisms of MTHFR are interesting targets for cancer risk studies. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 61-66 26939404-2 2016 Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme involved in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 26833750-6 2016 MTHFR G1793A showed a statistically significant interaction between dietary folate intake and gastric cancer. Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 0-5 26833750-7 2016 CONCLUSION: Our results suggest that MTR A2756G is significantly associated with gastric cancer risk, and that MTHFR G1793A statistically interacts with dietary folate intake. Folic Acid 161-167 methylenetetrahydrofolate reductase Homo sapiens 111-116 26687138-2 2016 There are two popular MTHFR polymorphisms known as C677T and A1298C which are found to be involved in folate metabolism and lowering the enzyme activity, thus may be linked with cancer development. Folic Acid 102-108 methylenetetrahydrofolate reductase Homo sapiens 22-27 26561410-0 2016 Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 89-94 26843177-1 2016 OBJECTIVES: Impairment of methylene tetrahydrofolate reductase (MTHFR), a key enzyme in the folate metabolism, results in an elevated plasma level of homocysteine, considered an independent risk factor for cardiovascular (CV) disease. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 64-69 27905385-1 2016 AIM: To study a role of MTHFR mutations and their associations with the disturbances of basic parameters of the folate cycle in the development of ischemic stroke (IS). Folic Acid 112-118 methylenetetrahydrofolate reductase Homo sapiens 24-29 26273990-1 2016 Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions. Folic Acid 150-160 methylenetetrahydrofolate reductase Homo sapiens 0-35 26273990-1 2016 Methylenetetrahydrofolate reductase (MTHFR) protein catalyzes the only biochemical reaction which produces methyltetrahydrofolate, the active form of folic acid essential for several molecular functions. Folic Acid 150-160 methylenetetrahydrofolate reductase Homo sapiens 37-42 26898294-6 2016 We report three patients with severe MTHFR deficiency (enzyme activity <=1% of controls) who had undetectable levels of CSF 5-MTHF at diagnosis and while on treatment with either folic acid or calcium folinate. Folic Acid 182-192 methylenetetrahydrofolate reductase Homo sapiens 37-42 26987498-3 2016 In the present study, the aim was to evaluate MTHFR C677T and A1298C polymorphisms that play a role on folate metabolism in PE patients. Folic Acid 103-109 methylenetetrahydrofolate reductase Homo sapiens 46-51 27614738-3 2016 MTHFR is a key enzyme that regulates the folate metabolism which has an important role in DNA synthesis, repair, and methylation. Folic Acid 41-47 methylenetetrahydrofolate reductase Homo sapiens 0-5 26564107-1 2015 Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair and synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 26564107-1 2015 Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair and synthesis. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 0-35 26564107-1 2015 Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair and synthesis. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 37-42 26561410-0 2016 Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C > T Polymorphism on Folate Status. Folic Acid 123-129 methylenetetrahydrofolate reductase Homo sapiens 89-94 26561410-10 2016 CONCLUSIONS: Folate status was lower in the MTHFR 677TT and SLC19A1 80AA genotypes compared with corresponding reference genotypes. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 44-49 26307085-0 2015 High-dose folic acid supplementation alters the human sperm methylome and is influenced by the MTHFR C677T polymorphism. Folic Acid 10-20 methylenetetrahydrofolate reductase Homo sapiens 95-100 26307085-7 2015 The most marked loss of DNA methylation was found in sperm from patients homozygous for the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, a common polymorphism in a key enzyme required for folate metabolism. Folic Acid 111-117 methylenetetrahydrofolate reductase Homo sapiens 129-134 26307085-10 2015 Our data reveal alterations of the human sperm epigenome associated with high-dose folic acid supplementation, effects that were exacerbated by a common polymorphism in MTHFR. Folic Acid 83-93 methylenetetrahydrofolate reductase Homo sapiens 169-174 26333700-2 2015 This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 131-167 25796308-1 2015 BACKGROUND: Methylenetetrahydrofolate Reductase (MTHFR) polymorphisms by impairing folate metabolism may influence the development of allergic diseases. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 26333700-2 2015 This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 169-174 26333700-2 2015 This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 131-167 26333700-2 2015 This study was conducted to investigate whether indirect or direct exposure to folate and impaired folate metabolism, reflected as methylene-tetrahydrofolate reductase (MTHFR) C677T polymorphism, would contribute to the development of asthma and other allergic diseases. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 169-174 26333700-9 2015 CONCLUSIONS: It is indicated that maternal folic acid supplementation during early pregnancy may increase the risk of wheeze in early childhood and that the TT genotype of MTHFR C677T polymorphism impairing folic acid metabolism would be at high risk of asthma development. Folic Acid 43-53 methylenetetrahydrofolate reductase Homo sapiens 172-177 26333700-9 2015 CONCLUSIONS: It is indicated that maternal folic acid supplementation during early pregnancy may increase the risk of wheeze in early childhood and that the TT genotype of MTHFR C677T polymorphism impairing folic acid metabolism would be at high risk of asthma development. Folic Acid 207-217 methylenetetrahydrofolate reductase Homo sapiens 172-177 26535623-1 2015 The C677T and A1298C polymorphisms in methylene-tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 76-81 26380869-1 2015 Methylenetetrahydrofolate reductase (MTHFR) functions as a main regulatory enzyme in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 26629414-1 2015 The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 26629414-1 2015 The methylenetetrahydrofolate reductase (MTHFR) gene codes for the MTHFR enzyme which plays a key role in the pathway of folate and methionine metabolism. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 67-72 26095803-1 2015 Methylenetetrahydrofolate reductase (MTHFR) reduces 5",10"-methylenetetrahydrofolate to 5"-methyltetrahydrofolate, and is involved in remethylation of homocysteine to methionine, two important reactions involved in folate metabolism and methylation pathways. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 26269367-10 2015 Although 3 fetal MTHFR and DHFR genetic variants had no effect, the fetal MTHFR 677TT genotype was associated with significantly lower cord serum (P = 0.03) and higher cord RBC (P = 0.02) folate concentrations than those of the wild type. Folic Acid 188-194 methylenetetrahydrofolate reductase Homo sapiens 74-79 26677583-8 2015 Women carriers of the mutated variants of both, 677C>T and 1298A>C polymorphisms of the MTHFR gene should receive special perinatal care in order to prevent fetal defects and thrombosis-related complications during pregnancy It is vital to emphasize the significance of proper education of folate supplementation, especially in pregnant patients and women of reproductive age. Folic Acid 296-302 methylenetetrahydrofolate reductase Homo sapiens 94-99 26467879-2 2015 The MTHFR C677T gene decreases the bioavailability of folate and increases plasma homocysteine, a risk factor for thrombosis. Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 4-9 26337056-12 2015 MTHFR C677T and A1298C with low folate showed higher odds of low levels of high-density lipoprotein cholesterol (P for trend: 0.008 and 0.031). Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 0-5 25105440-2 2015 The genes MTHFR, MTR, MTRR, and TCN2 play key roles in folate metabolism. Folic Acid 55-61 methylenetetrahydrofolate reductase Homo sapiens 10-15 25544674-3 2015 We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 104-139 26214484-3 2015 Methylation levels of the MTHFR gene in placentas in two sets of gravidas were detected by methylation-specific polymerase chain reaction, plasma homocysteine levels were detected by enzyme-linked immunosorbent assay, and folic acid and vitamin B12 levels were detected by electrochemiluminescence. Folic Acid 222-232 methylenetetrahydrofolate reductase Homo sapiens 26-31 26046315-7 2015 Of the potentially susceptible polymorphisms, MTHFR 2572C>A was associated with increased homocysteine and decreased folate levels in the plasma based on MTHFR 677CC. Folic Acid 120-126 methylenetetrahydrofolate reductase Homo sapiens 46-51 26046315-7 2015 Of the potentially susceptible polymorphisms, MTHFR 2572C>A was associated with increased homocysteine and decreased folate levels in the plasma based on MTHFR 677CC. Folic Acid 120-126 methylenetetrahydrofolate reductase Homo sapiens 157-162 25788000-0 2015 Assessing the association between the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism and blood folate concentrations: a systematic review and meta-analysis of trials and observational studies. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 75-80 25788000-3 2015 OBJECTIVE: We assessed the association between MTHFR C677T genotypes and blood folate concentrations among healthy women aged 12-49 y. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 47-52 25788000-11 2015 CONCLUSIONS: Meta-analysis results (limited to the MA, the recommended population assessment method) indicated a consistent percentage difference in S/P and RBC folate concentrations across MTHFR C677T genotypes. Folic Acid 161-167 methylenetetrahydrofolate reductase Homo sapiens 190-195 26266420-6 2015 However, the MTHFR A1298C mutation may confer protection by elevating the serum folate level (p = 0.025). Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 13-18 26154858-2 2015 The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway. Folic Acid 14-24 methylenetetrahydrofolate reductase Homo sapiens 66-101 26154858-2 2015 The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway. Folic Acid 14-24 methylenetetrahydrofolate reductase Homo sapiens 103-108 25801246-0 2015 Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population. Folic Acid 85-91 methylenetetrahydrofolate reductase Homo sapiens 105-110 25801246-3 2015 The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G, and MTRR A66G, alter plasmatic folate and homocysteine concentrations, causing problems during the repairment, synthesis, and methylation of the genetic material. Folic Acid 101-107 methylenetetrahydrofolate reductase Homo sapiens 37-42 25841988-1 2015 Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) were considered to have some influence on both folate metabolism and cancer risk. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 62-67 25887077-1 2015 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 25985325-8 2015 As well, MTHFR C677T, A1298C and G1793A polymorphisms were related to elevated serum level of Hcy, and folate and vitamin B12 deficiency. Folic Acid 103-109 methylenetetrahydrofolate reductase Homo sapiens 9-14 25758986-0 2015 Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 37-42 25728832-2 2015 The current study examined folate metabolism as a potential mechanism of CVD and neurocognitive deficits by: 1) using endothelial dysfunction as a biomarker of CVD, and 2) comparing enzymes associated with neurocognition, CVD, and critical to folate metabolism, methylenetetrahydrofolate reductase (MTHFR) and catechol-o-methyl transferase (COMT). Folic Acid 27-33 methylenetetrahydrofolate reductase Homo sapiens 262-297 25728832-2 2015 The current study examined folate metabolism as a potential mechanism of CVD and neurocognitive deficits by: 1) using endothelial dysfunction as a biomarker of CVD, and 2) comparing enzymes associated with neurocognition, CVD, and critical to folate metabolism, methylenetetrahydrofolate reductase (MTHFR) and catechol-o-methyl transferase (COMT). Folic Acid 27-33 methylenetetrahydrofolate reductase Homo sapiens 299-304 25966173-2 2015 The analysis of polymorphisms in the MTHFR gene has revealed associations with cancer; in particular the C677T polymorphism, which has been suggested to affect folate metabolism, DNA methylation, synthesis, and repair, and to contribute to tumor promotion in the mammary gland. Folic Acid 160-166 methylenetetrahydrofolate reductase Homo sapiens 37-42 25510667-1 2015 The methylenetetrahydrofolate reductase (MTHFR) 677 C>T and 1298 A>C polymorphisms are associated with variations in folate levels, a phenomenon linked to the development of various malignancies. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 25758536-8 2015 The baseline concentration of serum folate in subjects with polymorphism combination, reduced folate carrier protein, RFC1-80 GA and methylenetetrahydrofolate reductase, MTHFR677 CT+TT, was lower than RFC1-80 AA and MTHFR677 CT+TT (p = 0.002). Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 133-168 25758536-9 2015 After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p < 0.0001). Folic Acid 6-16 methylenetetrahydrofolate reductase Homo sapiens 159-164 25758536-9 2015 After folic acid supplementation, a higher increase in the concentration of serum folate was detected in subjects with polymorphism combination RFC1-80 GA and MTHFR677 CC than RFC1-80 GG and MTHFR CT+TT combination (p < 0.0001). Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 159-164 25758536-12 2015 The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation. Folic Acid 107-113 methylenetetrahydrofolate reductase Homo sapiens 31-36 25758536-12 2015 The combination of RFC1-80 and MTHFR-677 polymorphisms had a profound affect on the concentration of serum folate in healthy subjects before and after folic acid supplementation. Folic Acid 151-161 methylenetetrahydrofolate reductase Homo sapiens 31-36 26137281-7 2015 The MTHFR 677CT/1298AC and MTHFR 1298AC+CC/TSER 2R3R genotypes in the presence of plasma folate levels <=4.12 ng/ml were associated with significantly increased CRC risk. Folic Acid 89-95 methylenetetrahydrofolate reductase Homo sapiens 4-9 26137281-7 2015 The MTHFR 677CT/1298AC and MTHFR 1298AC+CC/TSER 2R3R genotypes in the presence of plasma folate levels <=4.12 ng/ml were associated with significantly increased CRC risk. Folic Acid 89-95 methylenetetrahydrofolate reductase Homo sapiens 27-32 26137281-9 2015 Therefore, the data suggest that i) MTHFR polymorphisms combined with low plasma folate levels and ii) polymorphisms in folate metabolism-related genes combined with metabolic syndrome risk factors (hypertension and DM) increase the odds of developing CRC. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 36-41 25754229-1 2015 INTRODUCTION: Our objective was to investigate the association between gene polymorphisms of folate cycle (MTHFR 677 C>T, MTHFR 1298 A>C, MTR 2756 A>G, and MTRR 66 A>G) and the risk of pulmonary embolism (PE) in a case-control study. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 107-112 25754229-1 2015 INTRODUCTION: Our objective was to investigate the association between gene polymorphisms of folate cycle (MTHFR 677 C>T, MTHFR 1298 A>C, MTR 2756 A>G, and MTRR 66 A>G) and the risk of pulmonary embolism (PE) in a case-control study. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 125-130 25566964-3 2015 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism and DNA synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 25566964-4 2015 This study aims to examine whether single nucleotide polymorphisms (SNP) in the MTHFR gene are associated with risk and survival of breast cancer and serum folate levels in healthy controls. Folic Acid 156-162 methylenetetrahydrofolate reductase Homo sapiens 80-85 25915064-10 2015 A positive correlation between serum folate levels and peripheral blood MTHFR amplicon methylation status was also observed (r = 0.25, p = 0.023). Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 72-77 26140186-1 2015 BACKGROUND: The purpose of this study was to describe the association of MTHFR gene single nucleotide polymorphisms (C677T and A1298C) and maternal supplementary folate intake with orofacial clefts in the Iranian population. Folic Acid 162-168 methylenetetrahydrofolate reductase Homo sapiens 73-78 25219684-8 2015 Patients and their mothers carrying the MTHFR 667T allele showed lower serum folate than CC (P = 0.011 and P = 0.030, respectively). Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 40-45 25886278-11 2015 Pregnant women carrying the MTHFR 677TT genotype showed lower serum folate levels (p = 0.042) and higher Hcy levels (p = 0.003). Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 28-33 25318348-2 2015 Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 73-108 25318348-2 2015 Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 110-115 25318348-2 2015 Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 110-115 25318348-2 2015 Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 110-115 25283235-1 2015 OBJECTIVE: To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677C>T, 1298A>C and 1793G>A polymorphisms. Folic Acid 20-30 methylenetetrahydrofolate reductase Homo sapiens 164-199 26107198-1 2015 BACKGROUND: The MTHFR C677T polymorphism is a genetic alteration affecting an enzyme involved in folate metabolism, but its relationship to host susceptibility to prostate cancer remains uncertain. Folic Acid 97-103 methylenetetrahydrofolate reductase Homo sapiens 16-21 25107455-1 2015 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, which is essential for DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 25634728-0 2015 Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications. Folic Acid 34-44 methylenetetrahydrofolate reductase Homo sapiens 75-110 25634728-0 2015 Individualized supplementation of folic acid according to polymorphisms of methylenetetrahydrofolate reductase (MTHFR), methionine synthase reductase (MTRR) reduced pregnant complications. Folic Acid 34-44 methylenetetrahydrofolate reductase Homo sapiens 112-117 25634728-1 2015 OBJECTIVE: This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms of pregnant women in Jiaodong region in China, and to investigate whether folic acid supplementation affect the pregnancy complications. Folic Acid 283-293 methylenetetrahydrofolate reductase Homo sapiens 91-126 25634728-1 2015 OBJECTIVE: This study aimed to detect the genotype distributions and allele frequencies of methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase reductase (MTRR) A66G polymorphisms of pregnant women in Jiaodong region in China, and to investigate whether folic acid supplementation affect the pregnancy complications. Folic Acid 283-293 methylenetetrahydrofolate reductase Homo sapiens 128-133 26259392-2 2015 Methlenetetrahydrofolate reductase (MTHFR) mutation are commonly linked to folate metabolism with increased risk factor for the development of neural tube defects, recurrent pregnancy loss and development of several type of cancer but genetic interaction between two alleles of MTHFR has been poorly defined in ovarian cancer in India. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 36-41 26259392-2 2015 Methlenetetrahydrofolate reductase (MTHFR) mutation are commonly linked to folate metabolism with increased risk factor for the development of neural tube defects, recurrent pregnancy loss and development of several type of cancer but genetic interaction between two alleles of MTHFR has been poorly defined in ovarian cancer in India. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 278-283 26598833-0 2015 Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR). Folic Acid 14-20 methylenetetrahydrofolate reductase Homo sapiens 94-129 26598833-0 2015 Regulation of Folate-Mediated One-Carbon Metabolism by Glycine N-Methyltransferase (GNMT) and Methylenetetrahydrofolate Reductase (MTHFR). Folic Acid 14-20 methylenetetrahydrofolate reductase Homo sapiens 131-136 26598833-5 2015 We discovered that the MTHFR TT genotype significantly reduces folate-dependent remethylation under folate restriction, but it assists purine synthesis when folate is adequate. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 23-28 26598833-5 2015 We discovered that the MTHFR TT genotype significantly reduces folate-dependent remethylation under folate restriction, but it assists purine synthesis when folate is adequate. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 23-28 26598833-5 2015 We discovered that the MTHFR TT genotype significantly reduces folate-dependent remethylation under folate restriction, but it assists purine synthesis when folate is adequate. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 23-28 25283235-1 2015 OBJECTIVE: To study folic acid intake, folate status and pregnancy outcome after infertility treatment in women with different infertility diagnoses in relation to methylenetetrahydrofolate reductase (MTHFR) 677C>T, 1298A>C and 1793G>A polymorphisms. Folic Acid 20-30 methylenetetrahydrofolate reductase Homo sapiens 201-206 26745044-2 2015 Folate deficiency and methylenetetrahydrofolate reductase (MTHFR) as an important enzyme of folate and methionine metabolism are considered crucial for DNA synthesis and methylation. Folic Acid 41-47 methylenetetrahydrofolate reductase Homo sapiens 59-64 26929921-3 2015 This study aimed to evaluate the effect of high dose folic acid (FA) on serum Hcy and Lp(a) concentrations with respect to methylenetetrahydrofolate reductase (MTHFR) polymorphisms 677C T during pregnancy. Folic Acid 53-63 methylenetetrahydrofolate reductase Homo sapiens 123-158 28316696-1 2015 Background: One of the notable enzymes in the metabolism of folate is Methylenetetrahydrofolate reductase enzyme, this enzyme is necessary for some biological mechanisms. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 70-105 26421712-1 2015 AIM: The aim of this study was to investigate possible relationships among the A1298C (rs1801131) and C677T (rs1801133) polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and levels of homocysteine, vitamins B6, B12, folic acid and lipid profile, including oxidized low-density lipoprotein (ox-LDL), of adolescents at cardiovascular risk. Folic Acid 236-246 methylenetetrahydrofolate reductase Homo sapiens 141-176 27843994-2 2015 The MTHFR gene (OMIM: 607093) plays an important role in the folate metabolism. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 4-9 25341694-4 2014 The role of folic acid in carcinogenesis may be modulated by polymorphism C677T in MTHFR and tandem repeats 2R/3R in the promoter site of TYMS gene that are related to decreased enzymatic activity and quantity and availability of the enzyme, respectively. Folic Acid 12-22 methylenetetrahydrofolate reductase Homo sapiens 83-88 25217320-5 2014 The MTHFR 667 T allele and MTR 2756 G allele were associated with a higher risk of breast cancer in individuals with low folate intake, vitamin B6, and vitamin B12, but the association disappeared among subjects with moderate and high intake of folate, vitamin B6, and vitamin B12. Folic Acid 121-127 methylenetetrahydrofolate reductase Homo sapiens 4-9 25544674-3 2015 We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 141-146 25544674-3 2015 We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 159-164 25544674-3 2015 We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL. Folic Acid 123-129 methylenetetrahydrofolate reductase Homo sapiens 141-146 25366783-1 2014 We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 86-126 25322900-4 2014 MTHFR 677T allele carriers with middle or low tertile plasma folate (<14.7 nmol/L) had 8.2 % higher tHcy compared to the 677CC genotype (p < 0.01). Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 0-5 25549641-1 2014 OBJECTIVE: To explore the association between serum concentrations of folic acid and homocysteine (HCY), 5, 10-methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and schizophrenia. Folic Acid 70-80 methylenetetrahydrofolate reductase Homo sapiens 108-146 25549641-1 2014 OBJECTIVE: To explore the association between serum concentrations of folic acid and homocysteine (HCY), 5, 10-methylenetetrahydrofolate reductase (MTHFR) C667T polymorphism and schizophrenia. Folic Acid 70-80 methylenetetrahydrofolate reductase Homo sapiens 148-153 25302494-0 2014 A lower degree of PBMC L1 methylation in women with lower folate status may explain the MTHFR C677T polymorphism associated higher risk of CIN in the US post folic acid fortification era. Folic Acid 158-168 methylenetetrahydrofolate reductase Homo sapiens 88-93 25302494-1 2014 BACKGROUND: Studies in populations unexposed to folic acid (FA) fortification have demonstrated that MTHFR C677T polymorphism is associated with increased risk of higher grades of cervical intraepithelial neoplasia (CIN 2+). Folic Acid 48-58 methylenetetrahydrofolate reductase Homo sapiens 101-106 25302494-2 2014 However, it is unknown whether exposure to higher folate as a result of the FA fortification program has altered the association between MTHFR C677T and risk of CIN, or the mechanisms involved with such alterations. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 137-142 24637499-2 2014 Methylenetetrahydrofolate reductase (MTHFR) activity may affect the sensitivity of patients to folate-based chemotherapeutic drugs, thus influencing the relapse risk. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24458267-1 2014 PURPOSE: Meta-analyses have suggested an effect of MTHFR C677T genotype (rs1801133), a proxy for blood total homocysteine, on cardiovascular disease (CVD) in populations with low population dietary folate. Folic Acid 198-204 methylenetetrahydrofolate reductase Homo sapiens 51-56 24458267-2 2014 The aim was to examine the association and effect modification by serum folate and vitamin B12 levels between MTHFR and CVD-related outcomes in a general population with no mandatory folic acid fortification policy. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 110-115 25265565-1 2014 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolic pathway which catalyzes the irreversible conversion of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 25366783-1 2014 We investigated the association between dietary intake of folate, vitamin B6, and the 5,10-methylenetetrahydrofolate reductase (MTHFR) genotype with breast cancer. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 128-133 24894669-1 2014 An increasing body of evidence has shown that the amino acid changes at position 1298 might eliminate methylenetetrahydrofolate reductase (MTHFR) enzyme activity, leading to insufficient folic acid and subsequent human chromosome breakage. Folic Acid 187-197 methylenetetrahydrofolate reductase Homo sapiens 102-137 25036376-1 2014 Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme of folate metabolism. Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 25278626-4 2014 In patients supplemented with 0.4 mg/d folic acid undergoing ovarian hyperstimulation and oocyte pick-up, carriers of the MTHFR 677T mutation were found to have lower serum estradiol concentrations at ovulation and fewer oocytes could be retrieved from them. Folic Acid 39-49 methylenetetrahydrofolate reductase Homo sapiens 122-127 25146845-1 2014 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism and DNA synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24894669-1 2014 An increasing body of evidence has shown that the amino acid changes at position 1298 might eliminate methylenetetrahydrofolate reductase (MTHFR) enzyme activity, leading to insufficient folic acid and subsequent human chromosome breakage. Folic Acid 187-197 methylenetetrahydrofolate reductase Homo sapiens 139-144 25221392-4 2014 We hypothesize that the polymorphisms in ABCB1, Cyp2C9, Cyp2C19 and methylene tetrahydrofolate reductase (MTHFR) might result in differential expression resulting in differential drug transport, drug metabolism and folate metabolism, which in turn may contribute to the teratogenic impact of AEDs. Folic Acid 88-94 methylenetetrahydrofolate reductase Homo sapiens 106-111 25079578-1 2014 BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) deficiency is an inborn error of the folate-recycling pathway that affects the remethylation of homocysteine to methionine. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 25078601-7 2014 We found any interaction between MTHFR C677T and folate intake (P for interaction = 0.02). Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 33-38 25221401-2 2014 With this background, we aim to hypothesize that whether C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene contributes towards the risk of developing AD and its association with vitamin B12 and folate levels. Folic Acid 98-104 methylenetetrahydrofolate reductase Homo sapiens 116-121 25221401-8 2014 CONCLUSION: We concluded that the subjects with homozygous mutated alleles are more prone to AD and also pointed out the influence of presence/absence of MTHFR T allelic variants on serum folate and vitamin B12 levels. Folic Acid 188-194 methylenetetrahydrofolate reductase Homo sapiens 154-159 25237572-3 2014 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24725652-2 2014 The methylenetetrahydrofolate reductase (MTHFR) gene is a key determinant in the folate metabolism and previous studies reported a significant effect on AP-induced weight gain and related metabolic abnormalities. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 26835343-0 2014 Association of folate metabolism genes MTHFR and MTRR with multiple complex congenital malformation risk in Chinese population of Shanxi. Folic Acid 15-21 methylenetetrahydrofolate reductase Homo sapiens 39-44 26835343-3 2014 In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method. Folic Acid 158-164 methylenetetrahydrofolate reductase Homo sapiens 256-291 26835343-3 2014 In the present study 250 Chinese birth defects cases who suffered 1-8 types of birth defect disease phenotypes were subjected and two genetic variants in two folate metabolism key enzymes, rs1801394 of methionine synthase reductase (MTRR) and rs1801133 of methylenetetrahydrofolate reductase (MTHFR) were genotyped by using SNaPshot method. Folic Acid 158-164 methylenetetrahydrofolate reductase Homo sapiens 293-298 24532086-1 2014 Low folate intake in the presence of the functional MTHFR 677 C > T (rs1801133) polymorphism is an important cause of elevated homocysteine levels previously implicated in major depressive disorder (MDD) and many other chronic diseases. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 52-57 24532086-9 2014 Detection of the low-penetrance MTHFR 677 C > T mutation reinforces the importance of folate intake above the recommended daily dose to prevent or restore dysfunction of the methylation pathway. Folic Acid 89-95 methylenetetrahydrofolate reductase Homo sapiens 32-37 23807201-9 2014 A folate-MTHFR genotype interaction on CRT risk was found (P = 0.037): in the lower folate subgroup, TT patients showed a 2.4 higher OR for CRT (95% CI 0.484-11.891; P NS) than C-allele carriers. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 9-14 23807201-11 2014 CONCLUSIONS: In this cohort of acromegalic patients, CRT risk is increased in 677TT MTHFR patients with low plasma folate levels. Folic Acid 115-121 methylenetetrahydrofolate reductase Homo sapiens 84-89 24769206-1 2014 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the folate cycle, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 25140779-0 2014 [Association of folate metabolism genes MTRR and MTHFR with complex congenital abnormalities among Chinese population in Shanxi Province, China]. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 49-54 25047451-1 2014 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, had significant effects on the homocysteine levels. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 24744129-1 2014 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, which is essential for DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24970119-2 2014 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of the folate/methionine metabolic pathway and it is well established fact that folate deficiency causes pregnancy complications like recurrent pregnancy loss, preeclempsia and birth defects affected pregnancies. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24746944-9 2014 The gene MTHFR encodes the 5-MTHFR enzyme, which is involved in folate metabolism, and C677T/A1298C polymorphisms of this gene are related to decreased enzyme activity and consequent changes in homocysteine concentration. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 9-14 24746944-9 2014 The gene MTHFR encodes the 5-MTHFR enzyme, which is involved in folate metabolism, and C677T/A1298C polymorphisms of this gene are related to decreased enzyme activity and consequent changes in homocysteine concentration. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 29-34 24853127-3 2014 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24447348-2 2014 We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrahydrofolate reductase [MTHFR]) associate with significant adverse events (SigAE). Folic Acid 77-87 methylenetetrahydrofolate reductase Homo sapiens 178-213 24447348-2 2014 We examined whether single nucleotide polymorphisms (SNPs) in enzymes of the folic acid pathway (folylpoly-gamma-glutamate synthetase [FPGS], gamma-glutamyl hydrolase [GGH], and methylenetetrahydrofolate reductase [MTHFR]) associate with significant adverse events (SigAE). Folic Acid 77-87 methylenetetrahydrofolate reductase Homo sapiens 215-220 24460828-3 2014 Although the 5,10-methylenetetrahydrofolate reductase (MTHFR) enzyme participates in folate metabolism, several studies failed to find any association between NSCL/P and the MTHFR C677T and A1298C polymorphisms. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 55-60 24112451-1 2014 BACKGROUND: While several single nucleotide polymorphisms are known to influence the metabolism of folate, the methylene tetrahydrofolate reductase (MTHFR) gene has been the most extensively studied. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 111-147 24112451-1 2014 BACKGROUND: While several single nucleotide polymorphisms are known to influence the metabolism of folate, the methylene tetrahydrofolate reductase (MTHFR) gene has been the most extensively studied. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 149-154 24649091-2 2014 Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). Folic Acid 14-20 methylenetetrahydrofolate reductase Homo sapiens 105-140 24649091-2 2014 Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). Folic Acid 14-20 methylenetetrahydrofolate reductase Homo sapiens 142-147 24649091-2 2014 Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 105-140 24649091-2 2014 Two important folate-metabolizing enzymes involved in the folate/homocysteine metabolic pathway are 5,10-methylenetetrahydrofolate reductase (MTHFR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 142-147 24488626-1 2014 Methylenetetrahydrofolate reductase (MTHFR) is a central enzyme involved in regulating the metabolic function of folate, which plays a pivotal role in DNA synthesis, repair, and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24966971-1 2014 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24737431-2 2014 Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 43-48 24737431-2 2014 Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 171-176 24753765-3 2014 Decreases in folate consumption due to MTHFR polymorphism may affect production rate of keratinocytes of which had faster reproduction rates with a continuous DNA turnover and this may affect the clinical picture of psoriasis. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 39-44 24596472-0 2014 Folate Levels and Polymorphisms in the Genes MTHFR, MTR, and TS in Colorectal Cancer. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 45-50 24490800-1 2014 BACKGROUND: Methylentetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism and consequently could be an important factor for the efficacy of a treatment with 5-fluorouracil. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 48-53 24365028-11 2014 MTHFR is an enzyme involved in the folate pathway and in de novo nucleotide biosynthesis but also a good example for gene-environment interaction in phenotype development. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 0-5 24615072-8 2014 Moreover, H. pylori infection, folate intake, and location of the tumor showed a significant interaction with the MTHFR C677T polymorphism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 114-119 24615072-9 2014 Our study suggests a protective role of MTHFR 677TT and high folate intake against gastric cancer, and the effect of the MTHFR C677T genotype may differ by H. pylori infection, folate consumption, and tumor site. Folic Acid 177-183 methylenetetrahydrofolate reductase Homo sapiens 121-126 24183284-8 2014 We conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, may act as a genetic susceptibility factor for migraine, MA in particular among the subjects of Asian descent. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 27-32 24183284-8 2014 We conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, may act as a genetic susceptibility factor for migraine, MA in particular among the subjects of Asian descent. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 82-87 24749352-0 2014 [Study on the relationship between the MTHFR polymorphism, the level of the folic acid and the cervical cancer susceptibility]. Folic Acid 76-86 methylenetetrahydrofolate reductase Homo sapiens 39-44 24385382-1 2014 Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are considered to have some influence on both folate metabolism and cancer risk. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 62-67 24326202-6 2014 RESULTS: Association between 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C>T and NTDs was significant in all stratifications (all P<.05), and synergistic effects of no folate supplementation and GDM were shown on NTD occurrence. Folic Acid 53-59 methylenetetrahydrofolate reductase Homo sapiens 71-76 24326202-8 2014 CONCLUSIONS: MTHFR 677C>T genotype, especially in case of no folate supplementation and GDM, promotes NTD occurrence. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 13-18 24380661-2 2014 MTHFR is a critical enzyme in folate metabolism that catalyzes the irreversible conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, thus playing a vital role in DNA synthesis and DNA methylation. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 0-5 23996892-10 2014 CONCLUSION: Our data demonstrated that reduced MTHFR activities associated with the MTHFR T allele may interact with RBC folate as the risk modifiers of lymphocytic p53 oxidative lesions of HCC patients. Folic Acid 121-127 methylenetetrahydrofolate reductase Homo sapiens 47-52 23996892-10 2014 CONCLUSION: Our data demonstrated that reduced MTHFR activities associated with the MTHFR T allele may interact with RBC folate as the risk modifiers of lymphocytic p53 oxidative lesions of HCC patients. Folic Acid 121-127 methylenetetrahydrofolate reductase Homo sapiens 84-89 24131523-2 2014 A common polymorphism (677C T) in the MTHFR gene results in reduced MTHFR activity in vivo which in turn leads to impaired folate metabolism and elevated homocysteine concentrations. Folic Acid 123-129 methylenetetrahydrofolate reductase Homo sapiens 38-43 24131523-2 2014 A common polymorphism (677C T) in the MTHFR gene results in reduced MTHFR activity in vivo which in turn leads to impaired folate metabolism and elevated homocysteine concentrations. Folic Acid 123-129 methylenetetrahydrofolate reductase Homo sapiens 68-73 24131523-9 2014 Preliminary evidence has suggested that there may be a much greater need for women with the MTHFR 677TT genotype to adhere to the specific recommendation of commencing folic acid prior to conception for the prevention of NTD, but this requires further investigation. Folic Acid 168-178 methylenetetrahydrofolate reductase Homo sapiens 92-97 25081713-1 2014 BACKGROUND: Methylenetetrahydrofolate (MTHFR) is the key enzyme of the folate metabolic pathway and several studies have pointed to association between the MTHFR C677T polymorphism and breast cancer risk. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 39-44 25081713-1 2014 BACKGROUND: Methylenetetrahydrofolate (MTHFR) is the key enzyme of the folate metabolic pathway and several studies have pointed to association between the MTHFR C677T polymorphism and breast cancer risk. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 156-161 24277487-0 2014 5,10-Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms: genotype frequency and association with homocysteine and folate levels in middle-southern Italian adults. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 24277487-1 2014 Two genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene (C677T and A1298C) can influence the plasma homocysteine (Hcy) levels, especially in the presence of an inadequate folate status. Folic Acid 48-54 methylenetetrahydrofolate reductase Homo sapiens 66-71 24277487-2 2014 The aim of this study was to evaluate the frequencies of C677T and of A1298C MTHFR polymorphisms and their correlation with Hcy and serum folate concentrations in a population of blood donors living in a region of middle-southern Italy (the Molise Region). Folic Acid 138-144 methylenetetrahydrofolate reductase Homo sapiens 77-82 24277487-7 2014 In conclusion, we found a high frequency of MTHFR allele associated with high level of Hcy and low levels of folate in an Italian southern population. Folic Acid 109-115 methylenetetrahydrofolate reductase Homo sapiens 44-49 24839819-1 2014 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is the key enzyme for folate metabolism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 25070812-1 2014 OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR C677T polymorphism has been suggested as a risk factor to various cancers. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 25070812-1 2014 OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR C677T polymorphism has been suggested as a risk factor to various cancers. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 112-117 25297611-0 2014 A cross-sectional study to find out the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotype with plasma levels of folate and total homocysteine by daily folate intake in Japanese. Folic Acid 75-81 methylenetetrahydrofolate reductase Homo sapiens 93-98 25297611-0 2014 A cross-sectional study to find out the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotype with plasma levels of folate and total homocysteine by daily folate intake in Japanese. Folic Acid 137-143 methylenetetrahydrofolate reductase Homo sapiens 56-91 25297611-0 2014 A cross-sectional study to find out the relationship of methylenetetrahydrofolate reductase (MTHFR) C677T genotype with plasma levels of folate and total homocysteine by daily folate intake in Japanese. Folic Acid 137-143 methylenetetrahydrofolate reductase Homo sapiens 93-98 23459165-2 2013 The single nucleotide polymorphisms, MTHFR C677T, A1298C, MTR A2756G and MTRR A66G, cause alteration in the homocysteine levels and reduced enzymatic activity that generates deficiency in the assimilation of folates associated with DNA damage; that is, why it is important to know if the single nucleotide polymorphisms are associated with the pathological characteristics and development of prostate cancer, through a case-control retrospective study. Folic Acid 208-215 methylenetetrahydrofolate reductase Homo sapiens 37-42 24532985-7 2013 It is believed that the increase in the concentration of Hcy in PD can affect genetic polymorphisms of the folate metabolic pathway genes, such as MTHFR (C677T, A1298C and G1793A), MTR (A2756G), and MTHFD1 (G1958A), whose frequencies tend to increase in PD patients, as well as the reduced concentration of B vitamins. Folic Acid 107-113 methylenetetrahydrofolate reductase Homo sapiens 147-152 24551672-10 2013 In conclusion, polymorphism of the MTHFR 677T is associated with small differences in BMD with folate levels. Folic Acid 95-101 methylenetetrahydrofolate reductase Homo sapiens 35-40 23846816-1 2013 Methylenetetrahydrofolate reductase (MTHFR) gene plays key roles not only in folate metabolism but also in carcinogenesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24338216-1 2014 Methylenetetrahydrofolate reductase (MTHFR) gene plays a pivotal role in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24052451-2 2014 5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 24052451-2 2014 5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 137-142 24052451-2 2014 5,10-methylenetetrahydrofolate reductase (MTHFR) is a folate-dependent enzyme that catalyzed remethylation of homocysteine (Hcy) and the MTHFR C677T polymorphism makes the MTHFR enzyme thermolabile causing hyperhomocysteinemia. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 137-142 24639841-6 2014 For those who had folate intake<450 ug/day, MTHFR 667TT genotype was associated with a higher risk of breast cancer (OR=2.45, 95% CI=1.09-5.82, P=0.02). Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 47-52 24639841-8 2014 A significant interaction was observed between MTHFR C667T polymorphism and folate intake on the risk of breast cancer (P for interaction was 0.025). Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 47-52 24639841-9 2014 CONCLUSION: This case-control study found a significant association between MTHFR C667T polymorphism, folate intake and vitamin B6 and breast cancer risk, and a significant interaction was observed between MTHFR C667T polymorphism and folate intake on the risk of breast cancer. Folic Acid 235-241 methylenetetrahydrofolate reductase Homo sapiens 76-81 24639841-9 2014 CONCLUSION: This case-control study found a significant association between MTHFR C667T polymorphism, folate intake and vitamin B6 and breast cancer risk, and a significant interaction was observed between MTHFR C667T polymorphism and folate intake on the risk of breast cancer. Folic Acid 235-241 methylenetetrahydrofolate reductase Homo sapiens 206-211 24014085-1 2014 Methylenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate metabolism which plays a key role in cell metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24393513-1 2013 This study examined associations between MTHFR C677T polymorphism and serum folate concentrations with the risk of esophageal precancerous lesions (EPL) and esophageal squamous cell carcinoma (ESCC). Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 41-46 24393513-5 2013 The MTHFR genotype may further modify associations between serum folate concentrations and the risk of ESCC, but it was not significantly associated with the risk of EPL. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 4-9 23595572-8 2013 Stratified analyses by plasma folate low (<7.4 ng/ml) or high (>=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 138-143 23595572-8 2013 Stratified analyses by plasma folate low (<7.4 ng/ml) or high (>=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 250-255 23595572-8 2013 Stratified analyses by plasma folate low (<7.4 ng/ml) or high (>=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Folic Acid 168-174 methylenetetrahydrofolate reductase Homo sapiens 138-143 23595572-8 2013 Stratified analyses by plasma folate low (<7.4 ng/ml) or high (>=7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. Folic Acid 168-174 methylenetetrahydrofolate reductase Homo sapiens 138-143 24129496-3 2013 Studies concerning the association between C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR), an important enzyme in folate metabolism, and ovarian cancer risk also resulted in no agreement. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 102-107 24048573-3 2013 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a key folate pathway enzyme involved in providing methyl groups from dietary folate for DNA methylation. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 23969624-12 2013 A common genetic variant of the MTHFR gene might impact the treatment effect of folate augmentation. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 32-37 24101362-10 2013 For SAH, interactions between MTR and MTHFR polymorphisms, and MTHFR polymorphism and serum folate were found. Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 63-68 24506394-2 2013 Methylenetetrahydrofolate reductase enzyme (MTHFR) participates in the metabolism of folate with the action of vitamins B6 and B12. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 44-49 23954881-1 2013 OBJECTIVE: Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism and it is thought to influence DNA methylation and nucleic acid synthesis. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 23959833-3 2013 It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 104-144 23959833-3 2013 It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 146-151 24068460-4 2013 Therefore, we carried out a meta-analysis of 26, 17, 9, 15, 9 and 6 case-control studies on the relationship between maternal methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, methionine synthase reductase (MTRR) A66G, reduced folate carrier 1 A80G and cystathionine beta-synthase 844ins68 polymorphisms and the risk of having a DS offspring. Folic Acid 145-151 methylenetetrahydrofolate reductase Homo sapiens 163-168 24301776-3 2013 As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate end-products. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 59-99 24301776-3 2013 As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate end-products. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 101-106 24301776-3 2013 As a key enzyme during folate metabolism, polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) may regulate folate end-products. Folic Acid 83-89 methylenetetrahydrofolate reductase Homo sapiens 101-106 24301776-4 2013 We investigated the effect of typical polymorphisms of MTHFR (C677T and A1298C) on MGMT methylation based on different serum folate levels in patients with glioma from Northeast China. Folic Acid 125-131 methylenetetrahydrofolate reductase Homo sapiens 55-60 24301776-12 2013 These data suggest that, in combination with a negative folate balance in glioma patients, T/T genotypes in MTHFR C677T may be associated with MGMT demethylation. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 108-113 24247802-2 2013 Among them, 5,10-methylenetetrahydrofolate reductase (MTHFR) is of special interest because of its involvement in regulation of the homocysteine level in the body as a result of folate metabolism. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 23653228-8 2013 Our study indicated that the MTHFR C677T polymorphism contributes to increased ASD risk, and periconceptional folic acid may reduce ASD risk in those with MTHFR 677C>T polymorphism. Folic Acid 110-120 methylenetetrahydrofolate reductase Homo sapiens 155-160 23765760-2 2013 Methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on risk of gliomas is still uncertain. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 23612630-1 2013 AIM: The present study attempts to understand the role of methylenetetrahydrofolate reductase C677T (MTHFR C677T) in recurrent pregnancy losses in North Indian women because of hyperhomocysteinemia in light of serum folate and vitamin B12. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 101-106 23670871-1 2013 BACKGROUND: This study examines gene-environment interaction between the MTHFR C667T polymorphism and folic acid in the etiology of orofacial clefts (OFC). Folic Acid 102-112 methylenetetrahydrofolate reductase Homo sapiens 73-78 23422951-1 2013 PURPOSES: Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 47-52 23422951-1 2013 PURPOSES: Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 10-45 23422951-1 2013 PURPOSES: Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism, and folate is implicated in carcinogenesis by its role in DNA methylation, repair, and synthesis. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 47-52 23522838-1 2013 Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism). Folic Acid 52-62 methylenetetrahydrofolate reductase Homo sapiens 163-168 23876493-9 2013 CONCLUSIONS: The MTHFR C677T polymorphism, which directly influences plasma folate levels, is not associated with CHD risk. Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 17-22 22983814-2 2013 Methyltetrahydrofolate reductase (MTHFR) gene mutation and low level of plasma vitamin B12 and folate could take part in the etiology of peripheral arterial disease (PAD). Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 34-39 23692062-1 2013 OBJECTIVES: To assess the associations of folate, homocysteine and vitamin B12 levels of children at birth and their methylenetetrahydrofolate reductase (MTHFR) variants with asthma and eczema in childhood. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 117-152 23692062-8 2013 In children carrying C677T mutations in MTHFR, higher folate levels were associated with an increased risk of eczema (repeated eczema until 4 years: OR 1.40 (95% CI 1.09-1.80) (SD change) P-interaction = 0.003, eczema ever at 6 years: OR 1.41 (0.97-2.03) P-interaction = 0.011). Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 40-45 23298970-0 2013 Elderly women: homocysteine reduction by short-term folic acid supplementation resulting in increased glucose concentrations and affecting lipid metabolism (C677T MTHFR polymorphism). Folic Acid 52-62 methylenetetrahydrofolate reductase Homo sapiens 163-168 23430981-1 2013 AIMS: The C677T variant in the methylenetetrahydrofolate reductase ( MTHFR ; EC 1.5.1.20) enzyme, a key player in the folate metabolic pathway, has been associated with increased risk of migraine with aura. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 69-74 23819405-7 2013 A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C>T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C>T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 37-72 23819405-7 2013 A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C>T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C>T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 74-79 23819405-7 2013 A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C>T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C>T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 82-117 23819405-7 2013 A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C>T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C>T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 150-155 23819405-7 2013 A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C>T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C>T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 150-155 23490201-1 2013 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 23816603-2 2013 Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of folate. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 23819405-7 2013 A key enzyme in folate metabolism is methylenetetrahydrofolate reductase (MTHFR - methylenetetrahydrofolate reductase), and 677C>T polymorphism of MTHFR gene is connected with lower enzymatic activity In several researches it was indicated that 677C>T MTHFR polymorphism is an independent factor influencing homocysteine concentration in serum, and also folate concentration in serum and red blood cells. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 82-117 23819405-10 2013 Women carriers of 677TT or 677CT MTHFR genotypes are exposed on folate metabolism disturbances and on the consequences of incorrect folate process during pregnancy Nowadays in this group of women folic acid supplementation is widely recommended. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 33-38 23819405-10 2013 Women carriers of 677TT or 677CT MTHFR genotypes are exposed on folate metabolism disturbances and on the consequences of incorrect folate process during pregnancy Nowadays in this group of women folic acid supplementation is widely recommended. Folic Acid 132-138 methylenetetrahydrofolate reductase Homo sapiens 33-38 23819405-10 2013 Women carriers of 677TT or 677CT MTHFR genotypes are exposed on folate metabolism disturbances and on the consequences of incorrect folate process during pregnancy Nowadays in this group of women folic acid supplementation is widely recommended. Folic Acid 196-206 methylenetetrahydrofolate reductase Homo sapiens 33-38 23295071-0 2013 Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 37-42 24353609-2 2013 Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 64-99 23456769-9 2013 Increases in RBC folate concentrations with 400 mug occurred within MTHFR gene mutation (C677T); and in the African American group. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 68-73 26105861-2 2013 INTRODUCTION: The MTHFR is a key enzyme in the folate cycle involved in homocysteine remethylation. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 18-23 22847291-1 2013 Methylenetetrahydrofolate reductase (MTHFR) is a central regulatory enzyme in the folate pathway. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 23276705-2 2013 Methylene tetrahydrofolate reductase (MTHFR) is a pivotal enzyme in folate metabolism. Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 23183238-1 2013 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 22527288-9 2013 Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 82-87 22527288-9 2013 Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 112-117 22527288-9 2013 Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173). Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 82-87 22527288-9 2013 Folate variants with the strongest independent effect on folate status were C677T-MTHFR (p = 0.0004) and G1793A-MTHFR (p = 0.0173). Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 112-117 23329275-1 2013 Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR polymorphisms have been suggested to be associated with risk of various cancers. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 23329275-1 2013 Methylenetetrahydrofolate reductase (MTHFR) enzyme plays an important role in folate metabolism and MTHFR polymorphisms have been suggested to be associated with risk of various cancers. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 100-105 24353609-9 2013 CONCLUSIONS: Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T. Folic Acid 120-126 methylenetetrahydrofolate reductase Homo sapiens 181-186 23508410-8 2013 Compared with the MTHFR 677CC genotype, the CT and TT variants, both of which were related to lower folate concentrations, were associated with reduced prostate cancer risk [OR 0.82 (0.72-0.94) and OR 0.78 (0.64-0.94), respectively]. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 18-23 23803097-1 2013 Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 24051386-2 2013 The aim of the present study was to investigate associations between folate intake, red blood cell (RBC) folate, total homocysteine (tHcy) and the MTHFR 677T allele. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 147-152 23534726-2 2013 Previous studies regarding the association of folate intake and Methylenetetrahydrofolate reductase C677T polymorphism with ESCC was conflicting. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 64-99 23534726-9 2013 CONCLUSIONS: Our meta-analysis indicated the folate intake and MTHFR 677CT/TT are associated with the risk of ESCC, and folate showed a significant interaction with polymorphism of MTHFR C677T. Folic Acid 120-126 methylenetetrahydrofolate reductase Homo sapiens 181-186 23534741-7 2013 The effect of MTHFR C677T polymorphisms on the risk of gastric cancer was modified by folate intake and methylation status of MGMT (P for interaction <0.05). Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 14-19 23116396-4 2013 MTHFR plays a key role in folate metabolism and in the homeostasis of homocysteine; mutations in the enzyme lead to hyperhomocyst(e)inemia. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 0-5 23076526-1 2013 5,10-Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate metabolism. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 23536781-1 2013 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme for folate metabolism in humans; it is encoded by the MTHFR gene. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 23536781-1 2013 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme for folate metabolism in humans; it is encoded by the MTHFR gene. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 133-138 23273201-1 2012 MTHFR is a key enzyme in folate metabolism that catalyzes the conversion of 5, 10&mdash;methlenetetrahydrofolate (5, 10&mdash; methylene THF) to 5&mdash;methyltetrahydrofolate (5&mdash;methyl THF), a predominant circulatory form of folate and methyl donor for the remethylation of homocysteine to methionine. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 0-5 23273201-1 2012 MTHFR is a key enzyme in folate metabolism that catalyzes the conversion of 5, 10&mdash;methlenetetrahydrofolate (5, 10&mdash; methylene THF) to 5&mdash;methyltetrahydrofolate (5&mdash;methyl THF), a predominant circulatory form of folate and methyl donor for the remethylation of homocysteine to methionine. Folic Acid 110-116 methylenetetrahydrofolate reductase Homo sapiens 0-5 23273201-13 2012 The T allele frequency of MTHFR (C667T) was found to be a significant risk factor for chronic pancreatitis playing a crucial role in altered folate metabolsim. Folic Acid 141-147 methylenetetrahydrofolate reductase Homo sapiens 26-31 23057736-1 2012 BACKGROUND: MTHFR 677C>T polymorphism is a genetic alteration in an enzyme involved in folate metabolism, but its effect on host susceptibility to cervical cancer is still uncertain. Folic Acid 90-96 methylenetetrahydrofolate reductase Homo sapiens 12-17 23096011-0 2012 Quantitation of whole-blood total folate within defined MTHFR C677T genotype groups by isotope dilution-liquid chromatography-tandem mass spectrometry differs from microbiologic assay. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 56-61 23346725-4 2012 This article describes how two SNPs, both of which are methylenetetrahydrofolate reductase (MTHFR) variants, can affect the way an individual metabolizes folate, resulting in elevated homocysteine level, and why testing for these SNPs may be important. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 92-97 23146986-1 2012 Methylene tetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of homocysteine to methionine, and folic acid is an essential cofactor. Folic Acid 120-130 methylenetetrahydrofolate reductase Homo sapiens 0-36 23146986-1 2012 Methylene tetrahydrofolate reductase (MTHFR) is an enzyme involved in the metabolism of homocysteine to methionine, and folic acid is an essential cofactor. Folic Acid 120-130 methylenetetrahydrofolate reductase Homo sapiens 38-43 23095111-3 2012 Several studies have suggested that polymorphisms in methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, reduced folate carrier (RFC1) G80A, and ABCB1 C3435T, could be related to methotrexate toxicity. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 90-95 23798054-4 2012 The most important genetic determinant of homocysteine in the general population is the common 677C T variant in the gene encoding the folate-metabolising enzyme, MTHFR; homozygous individuals (TT genotype) have reduced enzyme activity and elevated plasma homocysteine concentrations. Folic Acid 137-143 methylenetetrahydrofolate reductase Homo sapiens 165-170 22729883-1 2012 Methylenetetrahydrofolate reductase (MTHFR) is believed to be involved in folate metabolism which plays a critical role in carcinogenesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 23166529-3 2012 In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR). Folic Acid 7-13 methylenetetrahydrofolate reductase Homo sapiens 61-96 23166529-3 2012 In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR). Folic Acid 7-13 methylenetetrahydrofolate reductase Homo sapiens 98-103 22782530-10 2012 In conclusion, hyperhomocysteinaemia due to the MTHFR 677 C T polymorphism is associated with enhanced in vivo lipid peroxidation and platelet activation that are reversible, at least in part, following folic acid supplementation. Folic Acid 203-213 methylenetetrahydrofolate reductase Homo sapiens 48-53 22912935-10 2012 Increased risk was also apparent for average weekly alcohol consumption when accounting for the multiplicative interaction between folate intake and MTHFR C677T genotype (OR = 3.22; 95% CI: 1.36-7.59). Folic Acid 131-137 methylenetetrahydrofolate reductase Homo sapiens 149-154 22652272-3 2012 This study assesses the relation between homocysteine concentrations and MTHFR gene polymorphisms at two common alleles (C677T (rs1801133) and A1298C (rs1801131)) as well as other predictors of homocysteine (folate, vitamin B(12), body mass index (BMI), age, and gender) in a group of healthy Lebanese: 109 males and 124 females aged 17-55years. Folic Acid 208-214 methylenetetrahydrofolate reductase Homo sapiens 73-78 22695967-5 2012 Regression analyses of a cohort of 511 Czech controls not taking folate supplements revealed that only 2 variants in the MTHFR gene were associated with altered folate concentrations in plasma and/or erythrocytes. Folic Acid 161-167 methylenetetrahydrofolate reductase Homo sapiens 121-126 22695967-6 2012 In our previous study, we observed that the common variant MTHFR c.665C > T (known as c.677C > T; p.A222V) was associated with decreased plasma folate concentrations. Folic Acid 150-156 methylenetetrahydrofolate reductase Homo sapiens 59-64 22695967-7 2012 In the present study, we show in addition that the rare variant MTHFR c.1958C > T (p.T653M) is associated with significantly increased erythrocyte folate concentrations (P = 0.02). Folic Acid 150-156 methylenetetrahydrofolate reductase Homo sapiens 64-69 22695967-8 2012 Multivariate regression analysis revealed that this uncommon variant, which is present in 2% of Czech control chromosomes, explains 0.9% of the total variability of erythrocyte folate concentrations; the magnitude of this effect size was comparable with that of the common MTHFR c.665C > T variant. Folic Acid 177-183 methylenetetrahydrofolate reductase Homo sapiens 273-278 22693118-9 2012 The method was sensitive enough to measure the comprehensive erythrocyte folate distribution in a Down"s syndrome patient with extremely low folate, bearing the C677T mutation in the gene encoding for methylenetetrahydrofolate reductase. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 201-236 22693118-9 2012 The method was sensitive enough to measure the comprehensive erythrocyte folate distribution in a Down"s syndrome patient with extremely low folate, bearing the C677T mutation in the gene encoding for methylenetetrahydrofolate reductase. Folic Acid 141-147 methylenetetrahydrofolate reductase Homo sapiens 201-236 22668858-1 2012 Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is involved in folate and homocysteine metabolism, and has been associated with geriatric disorders, including dementia and late-life depression. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 22648721-7 2012 The association between folic acid and reduced ASD risk was strongest for mothers and children with MTHFR 677 C>T variant genotypes. Folic Acid 24-34 methylenetetrahydrofolate reductase Homo sapiens 100-105 21951971-3 2012 Methylenetetrahydrofolate reductase (MTHFR) genes play a key role not only in folate metabolism but also in esophagus, stomach, pancreatic carcinoma, and acute leukemias. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 22424391-3 2012 Our purpose was to test whether the MTHFR C677T (rs1801133) polymorphism affecting folate metabolism is associated with the occurrence or severity of npHI. Folic Acid 83-89 methylenetetrahydrofolate reductase Homo sapiens 36-41 22424391-8 2012 Among controls the known effect of MTHFR 677T on plasma total homocysteine was more pronounced in men than in women (p<0.00004 for genotype-sex interaction) suggesting that in Poland folate deficiency is more prevalent in males. Folic Acid 186-192 methylenetetrahydrofolate reductase Homo sapiens 35-40 22649255-1 2012 Genes functioning in folate-mediated 1-carbon metabolism are hypothesized to play a role in cardiovascular disease (CVD) risk beyond the current narrow focus on the MTHFR 677 C T (rs1801133) polymorphism. Folic Acid 21-27 methylenetetrahydrofolate reductase Homo sapiens 165-170 22132838-1 2012 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating the intracellular folate metabolism which plays an important role in carcinogenesis through DNA methylation and nucleotide synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 23056029-1 2012 BACKGROUND: Methylenetetrahydrofolate (MTHFR) enzyme plays an important role in folate metabolism which is involved in DNA methylation, repair, and synthesis. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 39-44 23171482-12 2012 On the contrary, the homozygous state for the 677T MTHFR variant may cause increased levels of homocysteine and/or an altered folate status and thus an increased risk for AMI, particularly in males. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 51-56 23155246-3 2012 In this case control study, we examined the combination of the polymorphisms MTHFR C677T and A1298C with MTR A2756G, where MTR, methionine synthase, is an important enzyme of the folate cycle in the methylation pathway. Folic Acid 179-185 methylenetetrahydrofolate reductase Homo sapiens 77-82 22847888-1 2012 Methylenetetrahydrofolate reductase (MTHFR), an important enzyme in folate metabolism, is thought to be involved in the development of nonsyndromic orofacial clefts (NSOC). Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 23166529-7 2012 To identify the genetic association with gastric cancer, we selected 17 SNPs sites in folate pathway-associated genes of MTHFR, MTR, and MTRR and tested in 1,261 gastric cancer patients and 375 healthy controls. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 121-126 22441130-2 2012 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial role in cells because folate availability is important for DNA integrity. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 53-58 22441130-2 2012 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial role in cells because folate availability is important for DNA integrity. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 11-51 22441130-2 2012 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR), involved in folate metabolism, plays a crucial role in cells because folate availability is important for DNA integrity. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 53-58 22706675-2 2012 This study tested the hypothesis that maternal folic acid supplementation before or during pregnancy reduces AL risk, accounting for the SNPs rs1801133 (C677T) and rs1801131 (A1298C) in MTHFR and rs1801394 (A66G) and rs1532268 (C524T) in MTRR, assumed to modify folate metabolism. Folic Acid 47-57 methylenetetrahydrofolate reductase Homo sapiens 186-191 22230335-1 2012 OBJECTIVE: To evaluate the effects on anencephaly risk of the interaction between the maternal profile of folate, vitamin B12 and homocysteine and the 677C T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR). Folic Acid 106-112 methylenetetrahydrofolate reductase Homo sapiens 192-227 22536880-2 2012 The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic acid metabolism and plays an essential role in inherited DNA methylation profiles. Folic Acid 68-78 methylenetetrahydrofolate reductase Homo sapiens 4-39 22536880-2 2012 The methylenetetrahydrofolate reductase (MTHFR) gene is involved in folic acid metabolism and plays an essential role in inherited DNA methylation profiles. Folic Acid 68-78 methylenetetrahydrofolate reductase Homo sapiens 41-46 22946297-1 2012 The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 228-263 22946297-1 2012 The work is dedicated to creation of the mathematical model of folate-dependent one-carbon unit metabolism (FOCM) and study of its function in human placenta under homocysteine load and the most common mutations in the genes of methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 265-270 21869730-1 2012 OBJECTIVES: To assess the influence of individual methylenetetrahydrofolate reductase (MTHFR) C677T and methionine synthase A2756G polymorphisms on the change of serum folate concentration in response to different dosages and durations of folic acid (FA) supplementation in hypertensive Chinese adults. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 87-92 21869730-9 2012 CONCLUSION: We demonstrated that MTHFR C677T polymorphisms can not only affect serum folate levels at the baseline and post-FA treatment, but also therapeutic responses to various dosages and durations of FA supplementation. Folic Acid 85-91 methylenetetrahydrofolate reductase Homo sapiens 33-38 22492374-8 2012 After stratification by period of follow-up, the inverse association of MTHFR with CVD mortality was significant only in the period after introduction of mandatory folic acid fortification. Folic Acid 164-174 methylenetetrahydrofolate reductase Homo sapiens 72-77 22495907-8 2012 The T allele of MTHFR rs1801133 was associated with a 2.8-fold increase of risk among Hispanic women whose dietary folate intake was <= 25th centile. Folic Acid 115-121 methylenetetrahydrofolate reductase Homo sapiens 16-21 22495907-9 2012 The C allele of MTHFR rs1801131 was associated with a two-fold increase of risk (OR = 2.0, 95% CI = 1.0-3.9) only among those whose dietary folate intake was >25th centile. Folic Acid 140-146 methylenetetrahydrofolate reductase Homo sapiens 16-21 22495907-11 2012 Maternal functional variants in MTHFR gene may interact with dietary folate intake and modify the conotruncal defects risk in the offspring. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 32-37 21489764-1 2012 AIMS: Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in regulating folate metabolism, which affects DNA synthesis and methylation. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 43-48 22152927-8 2012 People homozygous for the common C677T variant in the gene encoding the folate-metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR), typically have a 14-21% higher risk of CVD. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 100-135 22152927-8 2012 People homozygous for the common C677T variant in the gene encoding the folate-metabolising enzyme, methylenetetrahydrofolate reductase (MTHFR), typically have a 14-21% higher risk of CVD. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 137-142 22367721-6 2012 For the MTHFR polymorphisms, RRs (95% CIs) were 0.62 (0.44-0.90) for 677TT versus CC/CT and 0.68 (0.31-1.51) for 1298CC versus AC/AA, and these lower-risk genotypes were associated with lower circulating plasma folate levels. Folic Acid 211-217 methylenetetrahydrofolate reductase Homo sapiens 8-13 22370993-1 2012 Folate has been implicated in cardiovascular disease with atypical antipsychotic (AAPs) use, and individuals with methylenetetrahydrofolate reductase (MTHFR) and catechol-O-methyl transferase (COMT) variants are at greater risk. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 151-156 22084937-1 2012 In this study, our aim was to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism on the vitamin B12 therapy response in 95 patients with vitamin B12 deficiency and 92 healthy control subjects using vitamin B12, plasma total homocysteine (tHcy), and folate as the main measure of outcome. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 98-103 22106923-1 2012 AIMS: Two single nucleotide polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene, 677C/T and 1298A/C, encode the thermolabile isoforms of the MTHFR enzyme that adversely affect the folic acid metabolic pathway. Folic Acid 199-209 methylenetetrahydrofolate reductase Homo sapiens 49-85 22106923-1 2012 AIMS: Two single nucleotide polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene, 677C/T and 1298A/C, encode the thermolabile isoforms of the MTHFR enzyme that adversely affect the folic acid metabolic pathway. Folic Acid 199-209 methylenetetrahydrofolate reductase Homo sapiens 87-92 22106923-1 2012 AIMS: Two single nucleotide polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) gene, 677C/T and 1298A/C, encode the thermolabile isoforms of the MTHFR enzyme that adversely affect the folic acid metabolic pathway. Folic Acid 199-209 methylenetetrahydrofolate reductase Homo sapiens 160-165 22344247-11 2012 In univariate analyses, clinical variables including sex, age, and folate supplementation in addition to variations in MTHFR, MTR, and SLC25A32 were associated with differential intracellular folate redox concentrations. Folic Acid 192-198 methylenetetrahydrofolate reductase Homo sapiens 119-124 22411217-3 2012 The C677T and A1298C variants of methylenetetrahydrofolate reductase gene (MTHFR) have been shown to influence folate and homocysteine metabolisms. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 75-80 22230384-1 2012 BACKGROUND: This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults. Folic Acid 150-160 methylenetetrahydrofolate reductase Homo sapiens 196-231 22230384-1 2012 BACKGROUND: This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults. Folic Acid 150-160 methylenetetrahydrofolate reductase Homo sapiens 233-238 23244153-1 2012 AIM: The present case-control study was conducted to explore the association of MTHFR gene polymorphism and relations of P16, MGMT and HMLH1 to MTHFR and folate intake. Folic Acid 154-160 methylenetetrahydrofolate reductase Homo sapiens 80-85 22524840-8 2012 Individuals with high folate intake and the MTHFR 677CC genotype showed a significant decreased risk of esophageal cancer (0.43, 0.25-0.89). Folic Acid 22-28 methylenetetrahydrofolate reductase Homo sapiens 44-49 22799374-1 2012 OBJECTIVES: Since methylenetetrahydrofolate reductase (MTHFR) maintains the balance of circulating folate and methionine and blocks the formation of homocysteine, its regulation in relation to different cancers has extensively been studied in different populations. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 55-60 22799374-8 2012 These results for MTHFR polymorphism might be population specific in sporadic breast cancer affected patients but many other factors need to be excluded before making final conclusions including folate intake, population and disease heterogeneity. Folic Acid 195-201 methylenetetrahydrofolate reductase Homo sapiens 18-23 22901193-1 2012 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of MTHFR C677T polymorphism in cervical carcinogenesis is still controversial. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 22901193-1 2012 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of MTHFR C677T polymorphism in cervical carcinogenesis is still controversial. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 117-122 22901194-0 2012 Interactions between MTHFR C677T-A1298C variants and folic acid deficiency affect breast cancer risk in a Chinese population. Folic Acid 53-63 methylenetetrahydrofolate reductase Homo sapiens 21-26 22901194-1 2012 BACKGROUND: Our objective was to evaluate the MTHFR C677T-A1298C polymorphisms in patients with breast cancer and in individuals with no history of cancer, to compare the levels of genetic damage and apoptosis under folic acid (FA) deficiency between patients and controls, and to assess associations with breast cancer. Folic Acid 216-226 methylenetetrahydrofolate reductase Homo sapiens 46-51 22938427-1 2012 Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme involved in folate metabolism; a single nucleotide polymorphism (SNP) C677T has been reported to be linked with altered incidences of several diseases. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 21848426-1 2012 Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 53-88 21848426-1 2012 Two important polymorphisms of folate cycle enzymes, methylenetetrahydrofolate reductase (MTHFR) C677T and thymidylate synthase (TS) enhancer region (TSER) 28-bp tandem repeat, are related to risk of various types of cancer, including brain tumors, although there are few studies on this subject. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 90-95 22377700-5 2012 The polymorphisms MTHFR c.677C>T and solute carrier family 19 (folate transporter), member 1 (SLC19A1) c.80 A>G modulate folate concentrations, whereas the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) c.66A>G polymorphism affects the MMA concentration. Folic Acid 66-72 methylenetetrahydrofolate reductase Homo sapiens 18-23 22377704-6 2012 The associations of the MTHFR C677T polymorphism with osteoporosis/osteopenia and femoral neck BMD suggest that these polymorphisms confer a risk of developing osteoporosis in patients with rheumatoid arthritis, a risk that may be reduced with folate and B complex supplementation. Folic Acid 244-250 methylenetetrahydrofolate reductase Homo sapiens 24-29 21772318-0 2012 Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 124-129 21772318-3 2012 We also tested whether there was a main effect of methylenetetrahydrofolate reductase (MTHFR) C677T genotype (which influences folate metabolism and intracellular levels of folate metabolites and homocysteine) on change in depression scores, and carried out our analysis of folic acid supplementation and depression stratifying by genotype. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 87-92 21772318-3 2012 We also tested whether there was a main effect of methylenetetrahydrofolate reductase (MTHFR) C677T genotype (which influences folate metabolism and intracellular levels of folate metabolites and homocysteine) on change in depression scores, and carried out our analysis of folic acid supplementation and depression stratifying by genotype. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 87-92 21819229-3 2012 There is evidence to suggest that MTHFR C677T and A1298C polymorphisms alter the function of the enzyme, causing reduced folate and increased homocysteine levels in plasma. Folic Acid 121-127 methylenetetrahydrofolate reductase Homo sapiens 34-39 22605962-8 2012 Moreover, MTHFR 677CC carriers with higher folate intake showed a lower risk of death from ovarian cancer (HR = 0.32, 95% CI = 0.27-0.82). Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 10-15 22277790-1 2012 BACKGROUND: Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 59-99 22277790-1 2012 BACKGROUND: Intracellular folate hemostasis depends on the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 101-106 23090267-1 2012 OBJECTIVES: The methylenetetrahydrofolate reductase (MTHFR) enzyme activity plays an important role in the metabolism of folate within methionine-homocysteine pathway and, consequently, in the development of vascular diseases. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 53-58 22457816-1 2012 The methylenetetrahydrofolate reductase (MTHFR) gene is one of the main regulatory enzymes involved in folate metabolism, DNA synthesis and remethylation reactions. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 22457816-8 2012 Further studies are necessary to determine the influence of the environment, especially the consumption of diet folate on sperm counts of men with different MTHFR variants. Folic Acid 112-118 methylenetetrahydrofolate reductase Homo sapiens 157-162 22194208-1 2011 Methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 22194208-9 2011 MTHFR 677TT+CT genotypes had a significantly lower plasma folate concentration than those with the MTHFR 677CC genotype. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 0-5 22194208-10 2011 MTHFR 1298AC+CC genotypes had a lower plasma folate concentration than those with the MTHFR 1298AA genotype (P < 0.05). Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 0-5 22194208-14 2011 We conclude that plasma folate level is influenced by MTHFR genotypes. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 54-59 21525199-8 2011 Although a co-association with folate intake in childhood could explain this relation, the maternal methylenetetrahydrofolate reductase (MTHFR) genotype affected spine BMD independently of the child MTHFR genotype, which suggests that maternal folate status has an independent effect on bone development of offspring. Folic Acid 119-125 methylenetetrahydrofolate reductase Homo sapiens 137-142 21793799-1 2011 BACKGROUND: As a key enzyme in folate metabolism, 5,10- methylenetetrahydrofolate reductase (MTHFR) regulates the homeostasis between DNA synthesis and methylation. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 56-91 21793799-1 2011 BACKGROUND: As a key enzyme in folate metabolism, 5,10- methylenetetrahydrofolate reductase (MTHFR) regulates the homeostasis between DNA synthesis and methylation. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 93-98 21612398-3 2011 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism and two of its functional polymorphisms, MTHFR C677T and MTHFR A1298C, might be associated with NSOC susceptibility. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 21612398-3 2011 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism and two of its functional polymorphisms, MTHFR C677T and MTHFR A1298C, might be associated with NSOC susceptibility. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 129-134 21612398-3 2011 Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism and two of its functional polymorphisms, MTHFR C677T and MTHFR A1298C, might be associated with NSOC susceptibility. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 129-134 21451940-2 2011 Plasma Hcy is affected by 5,10-methylenetetrahydofolate reductase (MTHFR) genotype and dietary folate intake. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 67-72 21731042-0 2011 Increase in the prevalence of the MTHFR 677 TT polymorphism in women born since 1959: potential implications for folate requirements. Folic Acid 113-119 methylenetetrahydrofolate reductase Homo sapiens 34-39 21731042-1 2011 BACKGROUND/OBJECTIVES: Folate has been recognized to ensure reproductive health and there is a growing body of epidemiological evidence suggesting that the methylenetetrahydrofolate reductase (MTHFR) 677T allele and reduced dietary folate may increase the risk of cervical cancer. Folic Acid 175-181 methylenetetrahydrofolate reductase Homo sapiens 193-198 21967576-10 2011 Plasma folate level was inversely correlated with IBD risk associated with MTHFR C677T polymorphism (P=0.006). Folic Acid 7-13 methylenetetrahydrofolate reductase Homo sapiens 75-80 21967576-13 2011 Deficient folate status is associated with a higher impact of MTHFR C677T polymorphism on IBD risk. Folic Acid 10-16 methylenetetrahydrofolate reductase Homo sapiens 62-67 22108397-3 2011 However, some individuals have a genetic deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene that limits conversion of folic acid to its biologically active form, L-methylfolate. Folic Acid 135-145 methylenetetrahydrofolate reductase Homo sapiens 59-95 22108397-3 2011 However, some individuals have a genetic deficiency in the methylene tetrahydrofolate reductase (MTHFR) gene that limits conversion of folic acid to its biologically active form, L-methylfolate. Folic Acid 135-145 methylenetetrahydrofolate reductase Homo sapiens 97-102 22024018-3 2011 Methylenetetrahydrofolate reductase (MTHFR) plays a crucial role in regulating folate metabolism, which affects both DNA synthesis/repair and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 21955385-1 2011 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in bipolar disorder is controversial. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 21752986-4 2011 We also examined the interaction of these folate concentrations with polymorphisms in two enzymes [methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS)] in relation to the biochemical products. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 99-135 21752986-4 2011 We also examined the interaction of these folate concentrations with polymorphisms in two enzymes [methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS)] in relation to the biochemical products. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 137-142 21752986-7 2011 The relationship between folate concentrations and thymidylate synthesis was modified by genetic variation in TS but less so by variation in MTHFR. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 141-146 21607713-6 2011 Patients with MTHFR TT677 genotype showed higher plasma Hcy levels than controls, even after adjustment for folate levels (P < 0.05). Folic Acid 108-114 methylenetetrahydrofolate reductase Homo sapiens 14-19 22363213-2 2012 When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality. Folic Acid 5-11 methylenetetrahydrofolate reductase Homo sapiens 96-137 22363213-2 2012 When folate levels are low, the TT genotype of the common C677T polymorphism (rs1801133) of the methylene tetrahydrofolate reductase gene (MTHFR) appreciably increases homocysteine levels, so "Mendelian randomization" studies using this variant as an instrumental variable could help test causality. Folic Acid 5-11 methylenetetrahydrofolate reductase Homo sapiens 139-144 23275280-1 2012 Methylenetetrahydrofolate reductase (MTHFR) enzyme is one of the most important enzymes with a pivotal role in the folate metabolism and DNA synthesis pathways. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 21460376-1 2012 BACKGROUND: The association between dietary folate intake, two polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS), and survival in head and neck squamous cell carcinoma (HNSCC) patients is not clarified. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 117-122 22507617-5 2012 The relationships between MTHFR polymorphism and folate intake, serum folate or tHcy were investigated by dividing participants into CC, CT and TT types. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 26-31 22507617-8 2012 Therefore, MTHFR genotypes were proven to be a significant determinant for folate and tHcy concentrations. Folic Acid 75-81 methylenetetrahydrofolate reductase Homo sapiens 11-16 22799306-9 2012 CONCLUSION: The MTHFR 677T allele is associated with a lower risk of colorectal cancer in Asian populations, and there is effect modification by population plasma folate. Folic Acid 163-169 methylenetetrahydrofolate reductase Homo sapiens 16-21 22901166-1 2012 OBJECTIVE: Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 48-53 23098468-1 2012 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of the MTHFR C677T polymorphism in pancreatic carcinogenesis is still controversial. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 23098468-1 2012 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, and the role of the MTHFR C677T polymorphism in pancreatic carcinogenesis is still controversial. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 121-126 21878957-0 2012 Association of MTHFR and RFC1 gene polymorphism with hyperhomocysteinemia and its modulation by vitamin B12 and folic acid in an Indian population. Folic Acid 112-122 methylenetetrahydrofolate reductase Homo sapiens 15-20 23125859-2 2012 The objective was to determine whether relationships exist between the methylene-tetrahydrofolate reductase (MTHFR) polymorphisms and risk of colorectal cancer (CRC) and examine whether the risk is modified by level of folate intake. Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 109-114 23430891-8 2012 In all cases, after 3 months of folate supplementation (5 mg/day), both serum folate and tHcys concentrations returned to normal values.In conclusion, prior to the start of long-term Gly/Arg therapy, the monitoring of folate and plasma tHcys values, together with study of the 677C T polymorphism of the MTHFR gene, seems necessary in order to correct hyperhomocysteinemia by means of folate supplementation. Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 304-309 23056169-1 2012 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA methylation, DNA synthesis, and DNA repair. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 22470444-12 2012 Individuals with MTHFR 677CT or TT genotypes were at a greater risk of hyperhomocysteinemia in folate and vitamin B12 deficiencies and high blood lead (p value <0.05) level. Folic Acid 95-101 methylenetetrahydrofolate reductase Homo sapiens 17-22 21920590-2 2011 Previous studies, in other clinical settings, have suggested that polymorphisms in key folate metabolising enzymes such as 5,10-methylenetetrahydrofolate reductase (MTHFR) influence both toxicity and efficacy of methotrexate. Folic Acid 87-93 methylenetetrahydrofolate reductase Homo sapiens 123-163 21920590-2 2011 Previous studies, in other clinical settings, have suggested that polymorphisms in key folate metabolising enzymes such as 5,10-methylenetetrahydrofolate reductase (MTHFR) influence both toxicity and efficacy of methotrexate. Folic Acid 87-93 methylenetetrahydrofolate reductase Homo sapiens 165-170 21749215-2 2011 MTHFR deficiency is an autosomal recessive trait that could be a significant risk factor for a number of defects, for example, vascular events, due to lower dietary folate intake among South Indians. Folic Acid 165-171 methylenetetrahydrofolate reductase Homo sapiens 0-5 21967996-0 2011 Association between MTHFR C677T genotype and circulating folate levels irrespective of folate intake: data from the IMMIDIET Project. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 20-25 21868559-1 2011 BACKGROUND: The aim of this study was to explore the effect in stage III colorectal cancer of functional gene polymorphisms methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase (A2756G), in the folate metabolism on outcome and risk of toxicity for adjuvant chemotherapy. Folic Acid 143-149 methylenetetrahydrofolate reductase Homo sapiens 161-166 21367581-1 2011 OBJECTIVE: The aim was to investigate whether pregnancy-induced changes in total homocysteine (tHcy) are associated with folate and vitamin B12 nutritional status, genetic C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) enzyme, and gestation outcome at a time when folic acid supplementation started to be recommended in the Spanish health system. Folic Acid 287-297 methylenetetrahydrofolate reductase Homo sapiens 198-233 21690209-5 2011 By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease in the Met content, a trend toward increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e.g. positive relation between Hcy versus cysteine and folate versus GSH and negative relation between folate versus Hcy and both Hcy and cysteine versus GSH. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 49-54 21690209-5 2011 By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease in the Met content, a trend toward increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e.g. positive relation between Hcy versus cysteine and folate versus GSH and negative relation between folate versus Hcy and both Hcy and cysteine versus GSH. Folic Acid 390-396 methylenetetrahydrofolate reductase Homo sapiens 49-54 21690209-5 2011 By contrast, the combination of the heterozygous MTHFR genotype with folate deficiency in the samples from preeclamptic pregnancies was characterized by a statistically significant decrease in the Met content, a trend toward increased Hcy levels and a tight association between metabolically directly and indirectly related compounds, e.g. positive relation between Hcy versus cysteine and folate versus GSH and negative relation between folate versus Hcy and both Hcy and cysteine versus GSH. Folic Acid 390-396 methylenetetrahydrofolate reductase Homo sapiens 49-54 21803414-0 2011 Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 76-81 21803414-4 2011 We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C T and stroke in a genetic analysis and meta-analysis of randomised controlled trials. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 121-126 21803414-7 2011 FINDINGS: The effect of the MTHFR 677C T variant on homocysteine concentration was larger in low folate regions (Asia; difference between individuals with TT versus CC genotype, 3 12 mumol/L, 95% CI 2 23 to 4 01) than in areas with folate fortification (America, Australia, and New Zealand, high; 0 13 mumol/L, -0 85 to 1 11). Folic Acid 97-103 methylenetetrahydrofolate reductase Homo sapiens 28-33 21803414-7 2011 FINDINGS: The effect of the MTHFR 677C T variant on homocysteine concentration was larger in low folate regions (Asia; difference between individuals with TT versus CC genotype, 3 12 mumol/L, 95% CI 2 23 to 4 01) than in areas with folate fortification (America, Australia, and New Zealand, high; 0 13 mumol/L, -0 85 to 1 11). Folic Acid 232-238 methylenetetrahydrofolate reductase Homo sapiens 28-33 21803414-13 2011 Further large-scale genetic studies of the association between MTHFR 677C T and stroke in low folate settings are needed to distinguish effect modification by folate from small-study bias. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 63-68 21803414-13 2011 Further large-scale genetic studies of the association between MTHFR 677C T and stroke in low folate settings are needed to distinguish effect modification by folate from small-study bias. Folic Acid 159-165 methylenetetrahydrofolate reductase Homo sapiens 63-68 22022143-0 2011 Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population. Folic Acid 111-121 methylenetetrahydrofolate reductase Homo sapiens 29-34 21723457-14 2011 To avoid the risk of neural tube defects, pregnant women with a MTHFR mutation may require higher than normally recommended doses of folic acid supplementation for optimum health. Folic Acid 133-143 methylenetetrahydrofolate reductase Homo sapiens 64-69 20608880-1 2011 The goal of this study is to determine whether cardiovascular risk and the methylenetetrahydrofolate reductase 677 C->T polymorphism (MTHFR), an enzyme involved in folate metabolism and in epigenetics, are linked in morbidly obese non-diabetic adolescents. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 137-142 22303578-1 2011 INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) C677T is involved in folate and homocysteine metabolism. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 51-56 22303578-11 2011 CONCLUSION: MTHFR C677T polymorphism plays an important role in influencing the folate and homocysteine metabolism. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 12-17 21508090-0 2011 MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 0-5 21508090-0 2011 MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation. Folic Acid 136-146 methylenetetrahydrofolate reductase Homo sapiens 0-5 21508090-3 2011 OBJECTIVE: We sought to determine whether the MTHFR 677C T genotype modifies the response to folic acid supplementation during and 3 mo after discontinuation of supplementation. Folic Acid 93-103 methylenetetrahydrofolate reductase Homo sapiens 46-51 21508090-7 2011 RESULTS: Plasma and RBC folate and homocysteine concentrations were associated with MTHFR genotype throughout the supplementation trial, regardless of folic acid dose. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 84-89 21508090-8 2011 MTHFR TT was associated with lower folate concentrations, and the trend of TT < CC was maintained at even the highest doses. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 0-5 20850942-8 2011 Our results show that we should be aware of possible inborn errors of folate metabolism such as MTHFR deficiency, in infants with unexplained developmental delay manifesting rapidly progressive polyneuropathy. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 96-101 21093223-3 2011 Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the folate mediated methylation transfer reactions. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 21255267-10 2011 Although polymorphisms in the MTHFR gene may cause disturbances in folate metabolism, they do not appear to be accompanied by changes in cognitive functioning in old age. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 30-35 21334854-0 2011 Folate supplementation in schizophrenia: a possible role for MTHFR genotype. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 61-66 21334854-2 2011 This study examined the effect of folate supplementation on negative symptoms overall and in relation to MTHFR 677C>T genotype. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 105-110 21334854-9 2011 In addition, MTHFR status significantly moderated the relationship between change in serum folate and change in negative symptoms: among participants with at least one copy of the T allele negative symptoms were more likely to improve with increased serum folate (p=0.03). Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 13-18 21334854-9 2011 In addition, MTHFR status significantly moderated the relationship between change in serum folate and change in negative symptoms: among participants with at least one copy of the T allele negative symptoms were more likely to improve with increased serum folate (p=0.03). Folic Acid 256-262 methylenetetrahydrofolate reductase Homo sapiens 13-18 21334854-11 2011 However, a possible association between genotypes associated with reduced MTHFR activity and benefit from folate supplementation should be investigated further. Folic Acid 106-112 methylenetetrahydrofolate reductase Homo sapiens 74-79 21385350-9 2011 In addition, a subgroup analysis demonstrated that the favorable effect of the MTHFR 677T allele on the risk of developing hearing impairment was independent of folate and homocysteine level, whereas plasma total homocysteine level was independently associated with an increased risk of developing hearing impairment. Folic Acid 161-167 methylenetetrahydrofolate reductase Homo sapiens 79-84 21281325-6 2011 These results suggest the possibility that initiating folic acid supplementation prior to pregnancy may reduce the risk of having a LRD-affected pregnancy, especially in women whose offspring inherit one or two copies of the MTHFR 677T variant. Folic Acid 54-64 methylenetetrahydrofolate reductase Homo sapiens 225-230 20978181-1 2011 OBJECTIVE: The human methylenetetrahydrofolate reductase (MTHFR) gene plays a crucial role in folate metabolism. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 58-63 21123458-0 2011 MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline. Folic Acid 85-91 methylenetetrahydrofolate reductase Homo sapiens 0-5 21123458-1 2011 BACKGROUND: Homozygosity for the variant 677T allele in the methylenetetrahydrofolate reductase (MTHFR) gene increases the requirement for folate and may alter the metabolic use of choline. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 97-102 21050834-1 2011 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) involves in folic acid metabolism which influences DNA methylation. Folic Acid 68-78 methylenetetrahydrofolate reductase Homo sapiens 12-47 21050834-1 2011 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) involves in folic acid metabolism which influences DNA methylation. Folic Acid 68-78 methylenetetrahydrofolate reductase Homo sapiens 49-54 20978370-9 2011 Overall, folate was associated with increased methylation levels of RASSF1A and MTHFR and methionine was associated with decreased methylation levels of RASSF1A. Folic Acid 9-15 methylenetetrahydrofolate reductase Homo sapiens 80-85 21178087-1 2011 The enzymes serine hydroxymethyltransferase 1 (gene name SHMT1) and methylenetetrahydrofolate reductase (gene name MTHFR) regulate key reactions in folate-mediated one-carbon metabolism. Folic Acid 87-93 methylenetetrahydrofolate reductase Homo sapiens 115-120 20177420-5 2011 Methylenetetrahydrofolate reductase (MTHFR) generates active folate necessary for haematopoiesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 21070756-7 2011 CONCLUSION: Our findings provide support for the synergistic effects of polymorphisms in the folate metabolic pathway genes in PD susceptibility; the increased PD risk would be more significant in carriers with the polymorphisms of MTHFR, MTR, and MTRR genes. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 232-237 22296369-4 2011 The C677T variant lies in exon 4 at the folate binding site of the MTHFR gene and results in substitution of an alanine by a valine residue. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 67-72 22292644-2 2011 We here evaluated associations of the MTHFR C677T polymorphism and folate intake with esophageal cancer. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 38-43 21052817-1 2011 OBJECTIVE: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 111-116 21052817-5 2011 Low folate and the MTHFR 677 C > T variant were associated with a higher risk for CIN2/3 and cervical cancer vs. wild-type or heterozygous genotypes with high folate [OR, 2.39 (1.18-4.85) and 3.19 (1.43-7.13)]. Folic Acid 162-168 methylenetetrahydrofolate reductase Homo sapiens 19-24 21052817-7 2011 CONCLUSION: Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status. Folic Acid 188-194 methylenetetrahydrofolate reductase Homo sapiens 105-110 21625172-7 2011 We calculated the heritability and tested for associations between the MTHFR C677T functional variant and response to folic acid supplementation. Folic Acid 118-128 methylenetetrahydrofolate reductase Homo sapiens 71-76 21462086-7 2011 MTHFR 1298A>C influenced folate in male CIMP+ risk (P interaction < 0.01). Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 0-5 21462086-8 2011 Our findings suggest folate supplementation effects may differ between genders, perhaps due to variation in MTHFR and/or endogenous/exogenous hormones, and may be important in the initiation and progression of methylated rectal tumors in men. Folic Acid 21-27 methylenetetrahydrofolate reductase Homo sapiens 108-113 21109973-4 2011 In the present study, we sought to determine the following: i) genotype frequencies of MTHFR and MTR involved in folate metabolism in cases and cancer-free controls; and ii) the methylation status of three candidate genes (p16INK4A, p73 and hMLH1) in plasma related to the folate and homocysteine levels. Folic Acid 113-119 methylenetetrahydrofolate reductase Homo sapiens 87-92 21109973-5 2011 From genotype frequency analysis, individuals homozygous for the MTHFR 677TT genotype had a significantly reduced risk of developing colorectal cancer compared with those harboring the MTHFR 677CC genotype (OR, 0.206; 95% CI, 0.070-0.604; P=0.005), and had a lower plasma folate concentration than those with the MTHFR 677CC+CT genotype (P<0.05). Folic Acid 272-278 methylenetetrahydrofolate reductase Homo sapiens 65-70 21800644-2 2011 The authors represent more detailed information about the folate-related processes in human placenta, namely about the content of aminothiols at different allelic variants of placental methylenetetrahydrofolate reductase during the course of physiological pregnancy and preeclampsia. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 185-220 20421795-0 2010 Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 111-146 20421795-3 2010 We examined the impact of daily intake of folate, a co-factor in homocysteine metabolism, on plasma homocysteine and folate levels in CAD patients in relation with MTHFR genotypes. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 164-169 22432562-7 2010 Neither oral cancer cell line harbored the common C677T DNA polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene, which might reduce folate bioavailability. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 117-122 20923444-1 2011 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 22046205-7 2011 MTHFR C677T and A1298C gene polymorphisms were found to be similar in patients with and without MTX-related adverse events.In conclusion, A1298C and C677T polymorphisms in the MTHFR gene, were not related with MTX-related toxicity in RA patients receiving folate supplementation. Folic Acid 256-262 methylenetetrahydrofolate reductase Homo sapiens 176-181 21799811-1 2011 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme of folate and methionine metabolism, making it crucial for DNA synthesis and methylation. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 22203923-14 2011 Further evaluation on larger series is mandatory since homocysteine activity (related to MTHFR activity) could be easily influenced by folate or cobalamin derivatives. Folic Acid 135-141 methylenetetrahydrofolate reductase Homo sapiens 89-94 21125200-12 2010 In addition, the C677T-MTHFR association adds further support to existing findings underscoring the potential role of folate in depression. Folic Acid 118-124 methylenetetrahydrofolate reductase Homo sapiens 23-28 20696177-12 2010 CONCLUSIONS: In HTs with isolated PFO and H-Hcys, oral folate supplementation reduces Hcys levels both in TT and CT subjects with C667 T mutation of MTHFR. Folic Acid 55-61 methylenetetrahydrofolate reductase Homo sapiens 149-154 20236116-1 2010 Methylenetetrahydrofolate reductase (MTHFR) plays a major role in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 20721969-1 2010 Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to a compound which serves as a methyl donor for DNA methylation, an epigenetic modification known to be dysregulated in carcinogenesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 20552676-2 2010 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 20532609-9 2010 Subjects carrying the 5,10-methylenetetrahydrofolate reductase (MTHFR) CT or TT genotype had a lower DMA% and lower folate levels than those carrying the CC genotype. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 64-69 20097536-0 2010 Effect of the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism on plasma homocysteine concentrations in healthy children is influenced by consumption of folate-fortified foods. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 51-56 20097536-1 2010 OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 151-186 20097536-1 2010 OBJECTIVE: To explore the influence of folate-fortified foods (ready-to-eat [RTE] breakfast cereals or fruit-juice drinks) on the relation between the methylenetetrahydrofolate reductase (MTHFR 677C>T) polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 188-193 20456312-4 2010 The examinations included spirometry, measurements of serum folate and B12, specific IgE to inhalant allergens, total IgE, and genotyping of the MTHFR-C677T polymorphism - a genetic marker of impaired folate metabolism. Folic Acid 201-207 methylenetetrahydrofolate reductase Homo sapiens 145-150 20890936-2 2010 The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for having a child with NSCL/P. Folic Acid 159-169 methylenetetrahydrofolate reductase Homo sapiens 94-99 21180947-1 2010 UNLABELLED: Methylenetetrahydrofolate reductase gene (MTHFR) C677T polymorphism may be a risk factor for head and neck squamous cell carcinoma due to changes in folate levels that can induce disorders in the methylation pathway, which results in carcinogenesis. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 54-59 20552676-2 2010 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 0-40 20552676-2 2010 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a crucial enzyme in folate-mediated one-carbon metabolism and folate deficiency can be associated with psychiatric symptoms. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 42-47 20941748-1 2010 5,10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides, which are essential for DNA synthesis and methylation. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 21462116-3 2010 Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 126-131 20935396-2 2010 The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital for DNA synthesis and methylation reactions. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 48-53 20935396-3 2010 C677T and A1298C variants of MTHFR result in reduced plasma folate and increase the susceptibility to various multifactorial disorders. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 29-34 20097536-14 2010 Also, consumption of folate-fortified foods modulates the association of the MTHFR 677C>T polymorphism with tHcy, suggesting that habitual consumption of folate-fortified foods is a practical approach in providing consistent protection to those children who may benefit the most, i.e., carriers of the TT genotype. Folic Acid 21-27 methylenetetrahydrofolate reductase Homo sapiens 77-82 20097536-14 2010 Also, consumption of folate-fortified foods modulates the association of the MTHFR 677C>T polymorphism with tHcy, suggesting that habitual consumption of folate-fortified foods is a practical approach in providing consistent protection to those children who may benefit the most, i.e., carriers of the TT genotype. Folic Acid 157-163 methylenetetrahydrofolate reductase Homo sapiens 77-82 20944139-2 2010 Methylene tetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and is also an important source of DNA methylation and DNA synthesis (nucleotide synthesis). Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 21090237-0 2010 [Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia]. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 69-74 21090237-2 2010 We investigated the role of polymorphisms of folate metabolizing genes MTHFR (C677T and A1298C), SHMT1 (C1420T) and MTHFD (G1258A) in genetic susceptibility to this type of cancer. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 71-76 21044744-1 2010 BACKGROUND AND AIMS: The methylenetetrahydrofolate reductase (MTHFR) gene plays a key role in the metabolism of folate and homocysteine (Hcy) and its mutations have been associated with high serum Hcy level. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 62-67 20672355-2 2010 Many folate metabolism gene variants have been investigated, but only a few substantial associations have been established, the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene being one of the most significant. Folic Acid 5-11 methylenetetrahydrofolate reductase Homo sapiens 154-189 20672355-2 2010 Many folate metabolism gene variants have been investigated, but only a few substantial associations have been established, the C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene being one of the most significant. Folic Acid 5-11 methylenetetrahydrofolate reductase Homo sapiens 191-196 20670473-9 2010 Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 31-36 20670473-9 2010 Our results confirmed that the MTHFR 677 C to T mutation, especially in lower serum folate concentration status, results in the increase of serum tHcy levels which is bad for cognitive function and indicates that higher serum folate level is of benefit in keeping lower serum tHcy level and better cognitive function. Folic Acid 226-232 methylenetetrahydrofolate reductase Homo sapiens 31-36 21472308-2 2010 The enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are essential participants in folic acid metabolism and DNA synthesis. Folic Acid 121-131 methylenetetrahydrofolate reductase Homo sapiens 12-52 21472308-2 2010 The enzymes 5,10-methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are essential participants in folic acid metabolism and DNA synthesis. Folic Acid 121-131 methylenetetrahydrofolate reductase Homo sapiens 54-59 20544798-11 2010 In Caucasians, folate derivative levels were associated with vitamin use, B(12), and polymorphisms in MTHFR, TYMS, and RFC1. Folic Acid 15-21 methylenetetrahydrofolate reductase Homo sapiens 102-107 20504979-2 2010 The methylenetetrahydrofolate reductase (MTHFR) gene is important for folate metabolism, and 2 common polymorphisms, C677T and A1298C, reduce enzymatic activity; C677T is present at high penetrance in Mexican populations. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 20374669-3 2010 Inherited polymorphisms in key folate metabolic pathway genes, MTHFR and MTHFD, may influence the efficiency of folate metabolism and plasma level of homocysteine. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 63-68 20374270-1 2010 The methylenetetrahydrofolate reductase (MTHFR) encodes a major enzyme in folate metabolism. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 20356773-1 2010 Methylenetetrahydrofolate reductase (MTHFR) is a key enzymatic component of the folate cycle, converting 5,10-methylenetetrahydrofolate into 5-methyltetrahydrofolate, the methyl donor for remethylation of homocysteine into methionine. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 20386493-4 2010 RESULTS: RBC folate concentrations were significantly associated with MTHFR 677C>T (P=0.002), MTRR 66A>G (P<0.0001), MTHFD1 1958G>A (P=0.001) and SHMT 1420C>T (P=0.012), whereas no association of these polymorphisms with disease activity was observed. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 70-75 20374669-3 2010 Inherited polymorphisms in key folate metabolic pathway genes, MTHFR and MTHFD, may influence the efficiency of folate metabolism and plasma level of homocysteine. Folic Acid 112-118 methylenetetrahydrofolate reductase Homo sapiens 63-68 20447924-8 2010 However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; Ptrend) TT versus CC=1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC=0.74 (0.39-1.37); 0.34]. Folic Acid 242-248 methylenetetrahydrofolate reductase Homo sapiens 74-79 19821069-8 2010 Genetic analyses revealed homozygosity for the A allele of methylenetetrahydrofolate reductase (MTHFR) c.1298A>C (p.E429A), whereas other genetic variants of folate/methionine metabolism associated with MTX neurotoxicity were not present. Folic Acid 78-84 methylenetetrahydrofolate reductase Homo sapiens 96-101 20516537-1 2010 BACKGROUND & OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and involved in DNA synthesis, DNA repair and DNA methylation. Folic Acid 48-54 methylenetetrahydrofolate reductase Homo sapiens 66-71 20445408-1 2010 SUMMARY: Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 20221815-0 2010 MTHFR gene polymorphism and its relationship with plasma homocysteine and folate in a North Indian population. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 0-5 20221815-2 2010 This study evaluates MTHFR gene polymorphism and its relationship with plasma homocysteine and folate levels in a healthy North Indian population. Folic Acid 95-101 methylenetetrahydrofolate reductase Homo sapiens 21-26 19968891-8 2010 Low serum folate was associated with smoking, low alcohol intake, high coffee intake, unhealthy diet, and the TT genotype of the methylenetetrahydrofolate reductase (MTHFR)-C677T polymorphism. Folic Acid 10-16 methylenetetrahydrofolate reductase Homo sapiens 129-164 19968891-8 2010 Low serum folate was associated with smoking, low alcohol intake, high coffee intake, unhealthy diet, and the TT genotype of the methylenetetrahydrofolate reductase (MTHFR)-C677T polymorphism. Folic Acid 10-16 methylenetetrahydrofolate reductase Homo sapiens 166-171 19846322-4 2010 This case-control study examines the potential association among hyperhomocysteinaemia (hyper-Hcy), low serum folate and vitamin B(12) levels and the common C677T mutation of the MTHFR gene in patients with AMVT. Folic Acid 110-116 methylenetetrahydrofolate reductase Homo sapiens 179-184 20213658-7 2010 CONCLUSIONS: Our results suggest that the T allele of MTHFR C677T could be associated with susceptibility to SSNHL, and even imply that this mutation could be a risk factor that is independent of blood folic acid and homocysteine. Folic Acid 202-212 methylenetetrahydrofolate reductase Homo sapiens 54-59 19577428-0 2010 Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers. Folic Acid 8-14 methylenetetrahydrofolate reductase Homo sapiens 113-118 19746410-1 2010 Different lines of evidence indicate that methylenetetrahydrofolate reductase (MTHFR) functional gene polymorphisms, causative in aberrant folate-homocysteine metabolism, are associated with increased vulnerability to several heritable developmental disorders. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 79-84 20193847-1 2010 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate metabolic pathway. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 19923983-3 2010 MTHFR is central to folate metabolism and has two common functional polymorphisms (C677>T and A1298>C). Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 0-5 19669769-1 2010 BACKGROUND AND AIMS: The enzyme MTHFR plays an important role in folate metabolism, and folate is implicated in carcinogenesis due to its role in DNA methylation, repair, and synthesis. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 32-37 19577428-7 2010 High intakes of folate and vitamin B12 before diagnosis was associated with decreased gastric cancer mortality risk in susceptible MTHFR 677TT carriers (mortality risk for folate 0.14, 95% confidence interval 0.04-0.46, P for trend=0.001; mortality risk for vitamin B12 0.23, 95% confidence interval 0.08-0.66, P for trend=0.008). Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 131-136 19577428-7 2010 High intakes of folate and vitamin B12 before diagnosis was associated with decreased gastric cancer mortality risk in susceptible MTHFR 677TT carriers (mortality risk for folate 0.14, 95% confidence interval 0.04-0.46, P for trend=0.001; mortality risk for vitamin B12 0.23, 95% confidence interval 0.08-0.66, P for trend=0.008). Folic Acid 172-178 methylenetetrahydrofolate reductase Homo sapiens 131-136 19967264-4 2010 We review here the correlation between homocysteine metabolism and the disorders described above with genetic variants on genes coding for enzymes of homocysteine metabolism relevant to clinical practice, especially common variants of the MTHFR gene, 677C>T and 1298A>C. We also discuss the management of hyperhomocysteinemia with folic acid supplementation and fortification of folic acid and the impact of a decrease in the prevalence of congenital anomalies and a decline in the incidence of stroke mortality. Folic Acid 337-347 methylenetetrahydrofolate reductase Homo sapiens 239-244 19967264-4 2010 We review here the correlation between homocysteine metabolism and the disorders described above with genetic variants on genes coding for enzymes of homocysteine metabolism relevant to clinical practice, especially common variants of the MTHFR gene, 677C>T and 1298A>C. We also discuss the management of hyperhomocysteinemia with folic acid supplementation and fortification of folic acid and the impact of a decrease in the prevalence of congenital anomalies and a decline in the incidence of stroke mortality. Folic Acid 385-395 methylenetetrahydrofolate reductase Homo sapiens 239-244 20113291-1 2010 The frequency of the methylenetetrahydrofolate reductase enzyme (MTHFR) C677T mutation was determined using polymerase chain reaction (PCR) and with measurement of plasma total homocysteine (tHcy), folate, vitamins B6, B12 and disease severity in 102 SS children from Yemen. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 65-70 20071789-1 2010 INTRODUCTION: Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism and is involved in DNA synthesis, DNA repair and DNA methylation. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 51-56 19694922-0 2010 Treatment of erectile dysfunction due to C677T mutation of the MTHFR gene with vitamin B6 and folic acid in patients non responders to PDE5i. Folic Acid 94-104 methylenetetrahydrofolate reductase Homo sapiens 63-68 19283448-14 2010 Folate mean concentration was significantly lower in carriers of the wild-type MTHFR 1298AA genotype (P = 0.010). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 79-84 19283448-15 2010 CONCLUSION: Our results suggest a correlation between the MTHFR A1298C polymorphism and plasma folate concentration. Folic Acid 95-101 methylenetetrahydrofolate reductase Homo sapiens 58-63 20237899-1 2010 Two common mutations, 677 C-->T and a1298 A-->C, in the methylenetetrahydrofolate reductase gene (MTHFR) reduce the activity of MTHFR and folate metabolism. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 104-109 20237899-1 2010 Two common mutations, 677 C-->T and a1298 A-->C, in the methylenetetrahydrofolate reductase gene (MTHFR) reduce the activity of MTHFR and folate metabolism. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 134-139 19917061-0 2009 [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 157-192 19917061-0 2009 [6S]-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in women with the homozygous or wild-type 677C-->T polymorphism of methylenetetrahydrofolate reductase. Folic Acid 76-86 methylenetetrahydrofolate reductase Homo sapiens 157-192 19930673-1 2009 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 19759169-0 2009 Increased breast cancer risk at high plasma folate concentrations among women with the MTHFR 677T allele. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 87-92 19759169-2 2009 OBJECTIVES: We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C-->T (rs1801133) and 1298A-->C (rs1801131)]. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 122-157 19759169-2 2009 OBJECTIVES: We examined plasma folate (P-folate) concentration in relation to genotypes of the folate-metabolizing enzyme methylenetetrahydrofolate reductase [MTHFR 677C-->T (rs1801133) and 1298A-->C (rs1801131)]. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 159-164 19082889-2 2009 MTHFR plays a central role in biotransformation of folate to form S-adenosylmethionine, the universal methyl donor in cells and affects DNA methylation status. Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 0-5 20009482-2 2009 Therefore, one may expect that the lower availability of substrate for biochemical reactions leads to more genetic changes in enzyme function; for example, most studies have indicated the variant MTHFR genotype 677TT is related to biomarkers, such as homocysteine concentrations or global DNA methylation particularly in a low folate diet. Folic Acid 327-333 methylenetetrahydrofolate reductase Homo sapiens 196-201 19959403-11 2010 We also confirmed that MTHFR polymorphism has a significant effect on folate distribution in this small population of non-supplemented subjects. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 23-28 21173738-3 2010 Polymorphic genes involved in homocysteine and folate metabolism, including 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, are considered as an important risk factors for homocysteine accumulation and modulator of RM susceptibility. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 76-116 21173738-3 2010 Polymorphic genes involved in homocysteine and folate metabolism, including 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, are considered as an important risk factors for homocysteine accumulation and modulator of RM susceptibility. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 118-123 20661822-3 2010 Folate deficiency and functional polymorphisms in folate metabolizing genes such as methylene tetrahydrofolate reductase (MTHFR) 677C>T may have oncogenic role through disruption of normal DNA methylation pattern, synthesis, and impaired DNA repair. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 84-120 20661822-3 2010 Folate deficiency and functional polymorphisms in folate metabolizing genes such as methylene tetrahydrofolate reductase (MTHFR) 677C>T may have oncogenic role through disruption of normal DNA methylation pattern, synthesis, and impaired DNA repair. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 122-127 20066615-1 2010 AIM: This study aimed to investigate the 677C > T and 1298A > C MTHFR gene polymorphisms and their metabolic effects on the levels of folate, vitamin B12 and homocysteine in the serum of Turkish spina bifida occulta (SBO) patients and healthy individuals in disease. Folic Acid 140-146 methylenetetrahydrofolate reductase Homo sapiens 70-75 19963111-2 2009 Among these, the methylene tetrahydrofolate reductase gene (MTHFR) encodes an enzyme that converts folate to a methyl donor used for DNA methylation. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 60-65 20146887-2 2009 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 19814618-2 2009 Methylene tetrahydrofolate reductase (MTHFR) plays an important role for folate metabolism and is also an important source for DNA methylation and DNA synthesis (nucleotide synthesis). Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 18498357-9 2009 Screening of risk factors for thromboembolism revealed that all patients carried a methylenetetrahydrofolate reductase 677C-->T (MTHFR) mutation in a gene involved in folate metabolism, and either borderline or elevated homocysteine levels. Folic Acid 102-108 methylenetetrahydrofolate reductase Homo sapiens 132-137 20550866-5 2009 The C677T variant of the methylene-tetrahydrofolate reductase (MTHFR) gene is responsible of a thermolabile form, related to decrease of folate and increase homocysteine. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 63-68 19943541-1 2009 5,10-methylenetetrahydrofolate reductase (MTHFR) is the key enzyme in folate, methionine and homocysteine metabolism. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 19178944-1 2009 The reported correlation of defects in 5,10-methylenetetrahydrofolate reductase (MTHFR), the key enzyme of folate metabolism, with modulated risk for acute lymphoblastic leukemia (ALL) is ambiguous. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 81-86 19178944-4 2009 Mutations in the MTHFR gene decrease the onset risk of ALL with relapse in the setting of no folate supplementation in pregnancy, but not of relapse-free ALL. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 17-22 19657138-2 2009 The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 70-105 19657138-2 2009 The main regulating enzymes in folate and homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS). Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 107-112 19288150-10 2009 RESULTS: A significant reduction in diffuse GC risk was observed for MTHFR 677 TT genotype among individuals with high consumption of folate (OR = 0.23; 95% CI 0.06-0.84), choline (OR = 0.55; 95% CI 0.33-0.9) and Vitamin B(6) (OR = 0.59; 95% CI 0.36-0.96) compared to MTHFR 677 CC + CT carriers. Folic Acid 134-140 methylenetetrahydrofolate reductase Homo sapiens 69-74 19288150-10 2009 RESULTS: A significant reduction in diffuse GC risk was observed for MTHFR 677 TT genotype among individuals with high consumption of folate (OR = 0.23; 95% CI 0.06-0.84), choline (OR = 0.55; 95% CI 0.33-0.9) and Vitamin B(6) (OR = 0.59; 95% CI 0.36-0.96) compared to MTHFR 677 CC + CT carriers. Folic Acid 134-140 methylenetetrahydrofolate reductase Homo sapiens 268-273 19288150-12 2009 In contrast, carriers of the MTHFR 677 TT genotype with a low consumption of folate had a significant increased risk of intestinal GC (OR = 1.88 95% CI 1.02-3.47). Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 29-34 20021850-12 2009 The interaction analysis suggested that the low level of folacin intakes and the MTHFR 677TT genotype had a positive adding effect in the occurring of congenital heart disease. Folic Acid 57-64 methylenetetrahydrofolate reductase Homo sapiens 81-86 20021850-16 2009 There is interaction between folacin intakes and the MTHFR 677TT genotype. Folic Acid 29-36 methylenetetrahydrofolate reductase Homo sapiens 53-58 20021850-17 2009 Increasing the intakes of folacin among MTHFR 677TT genotype people might decrease the incidence rate of congenital heart disease. Folic Acid 26-33 methylenetetrahydrofolate reductase Homo sapiens 40-45 19578646-2 2009 Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and several polymorphisms have been described in the MTHFR gene. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 19578646-2 2009 Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and several polymorphisms have been described in the MTHFR gene. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 130-135 23105845-3 2009 MTHFR is a flavo enzyme and a key player in folate metabolism and changes in its activity could modify the susceptibility to Acute Lymphoblastic Leukemia (ALL). Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 0-5 19557016-1 2009 To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk, we conducted a case-control study with 669 cases and 682 population-based controls in the Jiangsu Province of China. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 88-128 19557016-1 2009 To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk, we conducted a case-control study with 669 cases and 682 population-based controls in the Jiangsu Province of China. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 130-135 19557016-11 2009 Among individuals with the MTHFR A1298C A/A genotype, adjusted ORs for breast cancer were 0.89 (0.62-1.27) and 1.69 (1.20-2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (tread test, P=0.0008). Folic Acid 167-173 methylenetetrahydrofolate reductase Homo sapiens 27-32 19557016-11 2009 Among individuals with the MTHFR A1298C A/A genotype, adjusted ORs for breast cancer were 0.89 (0.62-1.27) and 1.69 (1.20-2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (tread test, P=0.0008). Folic Acid 207-213 methylenetetrahydrofolate reductase Homo sapiens 27-32 20387639-6 2009 We have estimated the level of folate, components of methionine cycle--methionine and homocysteine, and related with methionine cycle cysteine and glutathione and polymorphism of methylentetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methyl-enetetrahydrofolate to 5-methyltetrahydrofolate, which serves as supplier of methyl group for methionine cycle. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 179-213 20387639-6 2009 We have estimated the level of folate, components of methionine cycle--methionine and homocysteine, and related with methionine cycle cysteine and glutathione and polymorphism of methylentetrahydrofolate reductase (MTHFR) catalyzes the irreversible conversion of 5,10-methyl-enetetrahydrofolate to 5-methyltetrahydrofolate, which serves as supplier of methyl group for methionine cycle. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 215-220 20387639-8 2009 In the samples-carriers of C/T genotype of MTHFR and in the group with complicated pregnancies the content of aminothiols and folates correlate in different directions with homocysteine level which serves as a marker of folate-dependent methionine cycle and related processes. Folic Acid 126-133 methylenetetrahydrofolate reductase Homo sapiens 43-48 20387639-8 2009 In the samples-carriers of C/T genotype of MTHFR and in the group with complicated pregnancies the content of aminothiols and folates correlate in different directions with homocysteine level which serves as a marker of folate-dependent methionine cycle and related processes. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 43-48 19954067-1 2009 OBJECTIVE: To evaluate the relationship between dietary folate intake and genetic polymorphisms of 5, 10-methylenetetrahydrofolate reductase (MTHFR) with reference to breast cancer risk. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 142-147 19954067-13 2009 Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0.89 (95% CI: 0.62 - 1.27) and 1.69 (95% CI: 1.20 - 2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (X2trend = 11.372, P = 0.001). Folic Acid 185-191 methylenetetrahydrofolate reductase Homo sapiens 27-32 19954067-13 2009 Among individuals with the MTHFR A1298C A/A genotype,adjusted OR for breast cancer were 0.89 (95% CI: 0.62 - 1.27) and 1.69 (95% CI: 1.20 - 2.36) for the second to the third tertile of folate intake compared with the highest folate intake group (X2trend = 11.372, P = 0.001). Folic Acid 225-231 methylenetetrahydrofolate reductase Homo sapiens 27-32 19604445-1 2009 OBJECTIVE: MTHFR is an enzyme involved in the folate pathway. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 11-16 19144510-4 2009 Two common non-synonymous variants, the C677T (Ala222Val) and A1298C (Glu429Ala), were described for the MTHFR gene and associated with a decreased enzymatic activity and an alteration of intracellular folate distribution. Folic Acid 202-208 methylenetetrahydrofolate reductase Homo sapiens 105-110 20680153-1 2009 BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and low folate levels are associated with inhibition of DNA methyltransferase and consequently DNA hypomethylation. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 58-63 19123462-4 2009 In HCT116 cells, the MTHFR 677T mutation was associated with significantly increased genomic DNA methylation when folate supply was adequate or high; however, in the setting of folate insufficiency, this mutation was associated with significantly decreased genomic DNA methylation. Folic Acid 114-120 methylenetetrahydrofolate reductase Homo sapiens 21-26 19123462-4 2009 In HCT116 cells, the MTHFR 677T mutation was associated with significantly increased genomic DNA methylation when folate supply was adequate or high; however, in the setting of folate insufficiency, this mutation was associated with significantly decreased genomic DNA methylation. Folic Acid 177-183 methylenetetrahydrofolate reductase Homo sapiens 21-26 19123462-5 2009 In contrast, in MDA-MB-435 cells, the MTHFR 677T mutation was associated with significantly decreased genomic DNA methylation when folate supply was adequate or high and with no effect when folate supply was low. Folic Acid 131-137 methylenetetrahydrofolate reductase Homo sapiens 38-43 19123462-5 2009 In contrast, in MDA-MB-435 cells, the MTHFR 677T mutation was associated with significantly decreased genomic DNA methylation when folate supply was adequate or high and with no effect when folate supply was low. Folic Acid 190-196 methylenetetrahydrofolate reductase Homo sapiens 38-43 19225123-0 2009 Does the MTHFR 677C-->T variant affect the Recommended Dietary Allowance for folate in the US population? Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 9-14 19225123-1 2009 BACKGROUND: The MTHFR 677C-->T variant is associated with reduced enzyme activity, abnormalities of folate metabolism, and potential increase in folate requirement. Folic Acid 103-109 methylenetetrahydrofolate reductase Homo sapiens 16-21 19225123-1 2009 BACKGROUND: The MTHFR 677C-->T variant is associated with reduced enzyme activity, abnormalities of folate metabolism, and potential increase in folate requirement. Folic Acid 148-154 methylenetetrahydrofolate reductase Homo sapiens 16-21 19174154-7 2009 In contrast, each weakly inhibits other enzymes of folate metabolism relevant to rheumatoid arthritis therapy (thymidylate synthase (EC 2.1.1.45), two formyltransferases of purine biosynthesis (EC 2.1.2.2 and EC 2.1.2.3), and 5,10-methylenetetrahydrofolate reductase (EC 1.5.1.20)). Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 231-266 19487547-1 2009 The 5,10-methyl-tetrahydrofolate reductase (MTHFR) enzyme plays a critical role in folate and homocysteine metabolism, and its gene, MTHFR, displays common genetic polymorphisms that influence its activity. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 44-49 19487547-1 2009 The 5,10-methyl-tetrahydrofolate reductase (MTHFR) enzyme plays a critical role in folate and homocysteine metabolism, and its gene, MTHFR, displays common genetic polymorphisms that influence its activity. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 133-138 19450180-2 2009 Recently, functionally significant SNPs in 5,10-methylenetetrahydrofolate reductase (MTHFR), a critical enzyme for intracellular folate homeostasis and metabolism, have been identified and characterized. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 85-90 19450180-3 2009 The MTHFR SNPs are ideal candidates for investigating the role of SNPs in cancer risk modification and treatment because of their well-defined and highly relevant biochemical effects on intracellular folate composition and one-carbon transfer reactions. Folic Acid 200-206 methylenetetrahydrofolate reductase Homo sapiens 4-9 19447376-2 2009 Numerous studies of MTHFR, encoding methylenetetrahydrofolate reductase, which catalyzes the rate-limiting step of folic acid biosynthesis, have shown inconsistent association of two common hypomorphic allelic variants, C677T and A1298C, in nsCL/P patients and, in some cases, their mothers. Folic Acid 115-125 methylenetetrahydrofolate reductase Homo sapiens 20-25 19447376-2 2009 Numerous studies of MTHFR, encoding methylenetetrahydrofolate reductase, which catalyzes the rate-limiting step of folic acid biosynthesis, have shown inconsistent association of two common hypomorphic allelic variants, C677T and A1298C, in nsCL/P patients and, in some cases, their mothers. Folic Acid 115-125 methylenetetrahydrofolate reductase Homo sapiens 36-71 19336565-1 2009 BACKGROUND: Single nucleotide polymorphisms (SNP) of the folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) may modify associations between folate intake and breast cancer. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 84-119 19336565-1 2009 BACKGROUND: Single nucleotide polymorphisms (SNP) of the folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR) may modify associations between folate intake and breast cancer. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 121-126 20298385-2 2009 However, there have been conflicting reports on the potential association between atopic disease and a common polymorphism of the methylene-tetrahydrofolate reductase (MTHFR)-gene, a well-known marker of impaired folate metabolism. Folic Acid 150-156 methylenetetrahydrofolate reductase Homo sapiens 168-173 19211833-1 2009 We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 242-277 19211833-1 2009 We previously showed that provision of the folate recommended dietary allowance and either 300, 550, 1100, or 2200 mg/d choline for 12 wk resulted in diminished folate status and a tripling of plasma total homocysteine (tHcy) in men with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 279-284 19211833-10 2009 Thus, in folate-deplete men, several factors with roles in 1-carbon metabolism interact with the MTHFR C677T genotype to affect plasma tHcy. Folic Acid 9-15 methylenetetrahydrofolate reductase Homo sapiens 97-102 19633796-3 2009 It has been proposed that C677T and A1298C polymorphisms of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in the folate pathway, could be related to its efficacy and toxicity. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 97-102 19121630-4 2009 Methylenetetrahydrofolate reductase (MTHFR) regulates intracellular folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 18511109-10 2009 We observed a significant correlation between folate and Hcy (r: 0.48; p=0.005) among homozygous for MTHFR. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 101-106 19577428-6 2010 RESULTS: MTHFR 677TT carriers with low folate and vitamin B12 intakes had the lowest survival rate in cases of gastric cancer. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 9-14 19852428-5 2009 Molecular analysis of 12 genetic polymorphisms involved in the folate metabolism revealed that the mother is heterozygous for the MTHFR C677T and TC2 A67G polymorphisms, and homozygous for the mutant MTRR A66G polymorphism. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 130-135 20075510-4 2009 To investigate the relationship between folate metabolism and Down syndrome (DS) in a Danish population, we analyzed the common 677C>T genetic polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 203-208 19421414-4 2009 METHODS: Methylenetetrahydrofolate reductase (MTHFR) catalyzes a critical step in folate metabolism, and genetic variation in MTHFR has been associated with several late-onset neurodegenerative diseases. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 19421414-4 2009 METHODS: Methylenetetrahydrofolate reductase (MTHFR) catalyzes a critical step in folate metabolism, and genetic variation in MTHFR has been associated with several late-onset neurodegenerative diseases. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 126-131 19838916-1 2009 We investigated associations among intake of folate, vitamin B2, vitamin B6, vitamin B12, and polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) genes and breast cancer risk in a Japanese population. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 153-158 20030812-10 2009 The most pronounced MTHFR-breast cancer risks were observed among women with the lowest intakes of dietary folate (P for interaction = 0.02) and total (diet plus supplemental) vitamin B(6) (P for interaction = 0.01), with no significant increased risks among women with higher intakes. Folic Acid 107-113 methylenetetrahydrofolate reductase Homo sapiens 20-25 18715139-10 2009 The association between MTHFR genotype and spine BMD was attenuated particularly in girls by high maternal dietary intakes of vitamin B(6) and folate during pregnancy but not by child dietary intakes at 7 yr. To the extent that these findings reflect known influences of C677T MTHFR genotype on plasma homocysteine levels, our results suggest that the latter is an important regulator of spinal BMD in childhood. Folic Acid 143-149 methylenetetrahydrofolate reductase Homo sapiens 24-29 19056652-0 2009 Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era. Folic Acid 127-137 methylenetetrahydrofolate reductase Homo sapiens 56-91 20066895-12 2009 Our study corroborates previous findings of an inverse association of the MTHFR 677TT genotype with colorectal cancer, in particular at high levels of folate. Folic Acid 151-157 methylenetetrahydrofolate reductase Homo sapiens 74-79 19180309-1 2009 OBJECTIVE: To asses the association between intake of folate and B vitamins and the incidence of spontaneous abortion (SA) according to the maternal methylenetetrahydrofolate reductase (MTHFR) polymorphisms (677 C>T and 1298 A>C). Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 186-191 18351371-2 2008 Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are critical enzymes of folate metabolic pathways. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 19133595-3 2008 Furthermore, genetic polymorphisms of the methylenetetrahydrofolate reductase gene can elevate the risk of congenital defects, particularly in children of mothers with low levels of folic acid. Folic Acid 182-192 methylenetetrahydrofolate reductase Homo sapiens 42-77 19133595-4 2008 To allow a sufficient supply with folic acid for persons with reduced enzymatic activity of the methylenetetrahydrofolate reductase, a supplementation with a combination of folic acid and 5-methyltetrahydrofolate can be performed. Folic Acid 34-44 methylenetetrahydrofolate reductase Homo sapiens 96-131 19133595-4 2008 To allow a sufficient supply with folic acid for persons with reduced enzymatic activity of the methylenetetrahydrofolate reductase, a supplementation with a combination of folic acid and 5-methyltetrahydrofolate can be performed. Folic Acid 173-183 methylenetetrahydrofolate reductase Homo sapiens 96-131 19803295-3 2008 It has been hypothesized that the maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. Folic Acid 43-53 methylenetetrahydrofolate reductase Homo sapiens 116-121 18996879-11 2008 CONCLUSION: These results show an association between the C677T MTHFR variant and different folate intakes on risk of CRC. Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 64-69 19091662-1 2008 Plasmatic homocysteine concentration depends mostly on 5,10 methylene tetrahydrofolate reductase (MTHFR) polymorphisms, a key enzyme in folate metabolism. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 98-103 19533869-1 2008 In order to prevent Alzheimer disease (AD), relationship between single nucleotide polymorphisms (SNPs) of methylene tetrahydrofolate reductase (MTHFR) and folate-homocysteine metabolism was studied. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 145-150 18669903-2 2008 We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG, then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 240-275 18669903-2 2008 We hypothesized that if folate pathway inhibition is the mechanism of cancer preventive activities of EGCG, then the protective effect against breast cancer would be stronger among women with low dietary folate intake and the high-activity methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TYMS) genotypes. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 277-282 18823966-1 2008 BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR), glutamate carboxypeptidase II (GCPII) and reduced folate carrier (RFC1) gene polymorphisms were associated with folate status. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 53-58 25855835-19 2008 MTHFR GENE POLYMORPHISMS AND RESPONSE TO CHEMOTHERAPY: Limited data preclude making meaningful inferences about the relationship between common variants in MTHFR and chemotherapy of the folate metabolic pathway. Folic Acid 186-192 methylenetetrahydrofolate reductase Homo sapiens 0-5 25855835-19 2008 MTHFR GENE POLYMORPHISMS AND RESPONSE TO CHEMOTHERAPY: Limited data preclude making meaningful inferences about the relationship between common variants in MTHFR and chemotherapy of the folate metabolic pathway. Folic Acid 186-192 methylenetetrahydrofolate reductase Homo sapiens 156-161 19080826-8 2008 Serum folate concentration decreased significantly with the mutation of the C677T genotype for MTHFR. Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 95-100 19080826-9 2008 Prevalence of deficits of folate (< 5.3 nmol/l) was 23.8% and raised significantly with the mutation of the C677T genotype for MTHFR: 18.8% for CC, 20.4% for CT, and 46.7% for TT. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 130-135 19080826-11 2008 CONCLUSIONS: Homozygosis mutation in C677T genotype of the enzyme MTHFR induces lower folate levels, mainly in girls after menstruation. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 66-71 18842806-6 2008 DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 213-249 18842806-6 2008 DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 251-256 18842806-7 2008 RESULTS: The MTHFR 677TT genotype was associated with increased plasma homocysteine and decreased plasma folate. Folic Acid 105-111 methylenetetrahydrofolate reductase Homo sapiens 13-18 19256756-1 2008 BACKGROUND: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer. Folic Acid 38-44 methylenetetrahydrofolate reductase Homo sapiens 77-112 19256756-1 2008 BACKGROUND: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer. Folic Acid 38-44 methylenetetrahydrofolate reductase Homo sapiens 114-119 19256756-1 2008 BACKGROUND: It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate for methylation reactions for DNA synthesis and repair, are involved in colorectal cancer. Folic Acid 96-102 methylenetetrahydrofolate reductase Homo sapiens 114-119 19256756-7 2008 Furthermore, a significant reduction in recurrence risk was seen in MTHFR G1793A heterozygotes limited to those who received folate supplements. Folic Acid 125-131 methylenetetrahydrofolate reductase Homo sapiens 68-73 18714187-1 2008 Genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) gene are thought to have significant effects on folate metabolism and, thus, on cancer risk, but the reported results are not always consistent. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 62-67 19031955-3 2008 Methylenetetrahydrofolate reductase (MTHFR) has a key role in the folate cycle. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 17896178-2 2008 Based on the hypothesis that variants of the cSHMT C1420T together with methionine synthase (MS A2756G) and 5,10-methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) are associated with breast cancer, we performed a multigenic case-control study of the effects to breast cancer risk of four polymorphisms of folate-metabolizing genes against duration of estrogen exposure. Folic Acid 132-138 methylenetetrahydrofolate reductase Homo sapiens 150-155 18322814-2 2008 A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 92-97 18322814-9 2008 No significant interaction was noted for total folate and MTHFR genotype, though an increased risk of recurrence noted for the MTHFR CT genotype was statistically significant only for those individuals with below median intake of total folate. Folic Acid 236-242 methylenetetrahydrofolate reductase Homo sapiens 127-132 18830030-5 2008 To all pregnant women Fraxiparin and vitamins of B group was appointed during pregnancy period; at presence of MTHFR a folic acid was appointed in addition. Folic Acid 119-129 methylenetetrahydrofolate reductase Homo sapiens 111-116 18398434-3 2008 The MTHFR 677TT genotype is known to be associated with increased homocysteine and decreased folate relative to CT heterozygotes and CC homozygotes in this and other populations. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 4-9 18398434-4 2008 MTHFR 677TT homozygotes who were also CBS 844ins68 carriers had homocysteine and folate concentrations similar to those of individuals with the MTHFR 677CT and CC genotypes. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 0-5 18398434-6 2008 These findings suggest that the CBS 844ins68 allele "normalizes" homocysteine and folate levels in MTHFR 677TT individuals. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 99-104 18614746-10 2008 CONCLUSIONS: The MTHFR 677C-->T polymorphism was associated with significant differences in serum folate and homocysteine concentrations in the US population before folic acid fortification. Folic Acid 168-178 methylenetetrahydrofolate reductase Homo sapiens 17-22 18633250-10 2008 A polymorphism that may influence the efficacy of 5-FU by influencing folate pools is that of the methylenetetrahydrofolate reductase(MTHFR)gene. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 98-133 18633250-10 2008 A polymorphism that may influence the efficacy of 5-FU by influencing folate pools is that of the methylenetetrahydrofolate reductase(MTHFR)gene. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 134-139 18165972-4 2008 The MTHFR 677TT genotype, and to a lesser extent the 677CT genotype, is associated with a significant elevation in the circulating concentrations of homocysteine and a decrease in serum folate concentrations. Folic Acid 186-192 methylenetetrahydrofolate reductase Homo sapiens 4-9 18703816-2 2008 Low folate levels, along with genetic polymorphisms in key enzymes such as methylene tetrahydrofolate reductase (MTHFR), can cause DNA hypomethylation and aberrant CpG methylation, which have been associated with colorectal tumor development. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 75-111 18703816-2 2008 Low folate levels, along with genetic polymorphisms in key enzymes such as methylene tetrahydrofolate reductase (MTHFR), can cause DNA hypomethylation and aberrant CpG methylation, which have been associated with colorectal tumor development. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 113-118 18703816-6 2008 High folate intake was associated with a decreased risk for colorectal adenoma (odds ratio, 0.47; 95% CI, 0.30-0.73; P(trend), <0.001), which was modified by MTHFR 1298 genotype (P(interaction) = 0.006). Folic Acid 5-11 methylenetetrahydrofolate reductase Homo sapiens 161-166 18703816-9 2008 Our data suggest that dietary folate intake may be an important determinant for premalignant colorectal disease development but not colorectal cancer, an association that is modified by MTHFR genotype. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 186-191 18768511-1 2008 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 18768511-2 2008 We assessed the association between two common MTHFR variants, 677C>T and 1298A>C, and adenoma recurrence in the context of a randomized double- blind clinical trial of aspirin use and folate supplementation. Folic Acid 191-197 methylenetetrahydrofolate reductase Homo sapiens 47-52 18514430-8 2008 A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 111-148 18514430-8 2008 A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 150-155 18514430-8 2008 A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status. Folic Acid 132-138 methylenetetrahydrofolate reductase Homo sapiens 150-155 18514430-8 2008 A particular polymorphic form to a key enzyme required to activate folate for methylation in neurodevelopment, 5-methylenetetrahydrofolate reductase (MTHFR), demonstrates reduced activity under low or normal folate levels but normal activity under conditions of higher folate nutritional status. Folic Acid 132-138 methylenetetrahydrofolate reductase Homo sapiens 150-155 18514430-12 2008 It is hypothesized here that the enhancement of maternal folate status before and during pregnancy in the last 15 years has altered natural selection by increasing survival rates during pregnancy of infants possessing the MTHFR C677T polymorphism, via reduction in hyperhomocysteinemia associated with this genotype and thereby miscarriage rates. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 222-227 18781847-1 2008 The 5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme for intracellular folate homeostasis and metabolism. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 18421714-1 2008 BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in folate metabolism. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 18822146-9 2008 MTHFR is an essential enzyme in folate metabolism and reduced folate levels are associated with both AUD and depression. Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 0-5 18822146-9 2008 MTHFR is an essential enzyme in folate metabolism and reduced folate levels are associated with both AUD and depression. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 0-5 18601742-4 2008 METHODS: 223 incident papillary thyroid cancer cases and 513 controls recruited from Saudi Arabian population were analyzed for the association between polymorphisms in genes encoding folic acid metabolizing enzymes MTHFR and six xenobiotics-metabolizing enzymes including CYP1A1 T3801C, C4887A, GSTP1 A1578G, C2293T, GSTM1, GSTT1, NAT2 G590A, NQO*1 C609T, using PCR-RELP. Folic Acid 184-194 methylenetetrahydrofolate reductase Homo sapiens 216-221 18614746-6 2008 RESULTS: For all race-ethnicity groups, serum folate and homocysteine concentrations were significantly related to the MTHFR 677C-->T genotype but not to the other polymorphisms. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 119-124 18614746-7 2008 Persons with the MTHFR 677 TT genotype had a 22.1% (95% CI: 14.6%, 28.9%) lower serum folate and a 25.7% (95% CI: 18.6%, 33.2%) higher homocysteine concentration than did persons with the CC genotype. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 17-22 18614746-8 2008 Moderate daily folic acid intake (mean: 150 microg/d; 95% CI: 138, 162) significantly reduced the difference in mean homocysteine concentrations between those with the MTHFR 677 CC and TT genotypes. Folic Acid 15-25 methylenetetrahydrofolate reductase Homo sapiens 168-173 18614746-10 2008 CONCLUSIONS: The MTHFR 677C-->T polymorphism was associated with significant differences in serum folate and homocysteine concentrations in the US population before folic acid fortification. Folic Acid 101-107 methylenetetrahydrofolate reductase Homo sapiens 17-22 18614746-11 2008 The effect of MTHFR 677C-->T on homocysteine concentrations was reduced by moderate daily folic acid intake. Folic Acid 93-103 methylenetetrahydrofolate reductase Homo sapiens 14-19 18616362-10 2008 CONCLUSION: While the inverse relation between the mother"s having the MTHFR C677T variant and both CL+/-P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain. Folic Acid 148-154 methylenetetrahydrofolate reductase Homo sapiens 71-76 18616362-10 2008 CONCLUSION: While the inverse relation between the mother"s having the MTHFR C677T variant and both CL+/-P and CP suggests perturbation of maternal folate metabolism is of etiological importance, contrasting relations between maternal postpartum levels of RBC and serum folate by type of cleft are difficult to explain. Folic Acid 270-276 methylenetetrahydrofolate reductase Homo sapiens 71-76 18426813-3 2008 The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate availability and may be a surrogate for measuring folate levels. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 18426813-3 2008 The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate availability and may be a surrogate for measuring folate levels. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 4-39 18426813-3 2008 The methylenetetrahydrofolate reductase (MTHFR) C677T TT genotype is associated with reduced folate availability and may be a surrogate for measuring folate levels. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 41-46 18595133-11 2008 CONCLUSION: We conclude that high concentrations of serum folate/vitamin B(12) levels are associated with the risk of promoter methylation in tumor-specific genes, and this relationship is modified by MTHFR C677T genotypes. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 201-206 18452180-11 2008 Of interest is the significant interaction (p = .008) towards a nearly twofold increased risk in mothers carrying the MTHFR 1298C allele and using a periconception folic acid supplement. Folic Acid 164-174 methylenetetrahydrofolate reductase Homo sapiens 118-123 18365141-1 2008 Polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, has been shown to affect the sensitivity of patients to folate-based drugs such as methotrexate. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 58-63 18365141-1 2008 Polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, has been shown to affect the sensitivity of patients to folate-based drugs such as methotrexate. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 16-56 18365141-1 2008 Polymorphism in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, has been shown to affect the sensitivity of patients to folate-based drugs such as methotrexate. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 58-63 18234410-6 2008 The C677T variant of MTHFR gene can also lead to hyperhomocysteinemia particularly when serum folate level is decreased. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 21-26 18446861-1 2008 Studies on the structure of the methylenetetrahydrofolate reductase (MTHFR) gene and the mechanisms by which folate may reduce homocysteine levels in bacteria and in humans have provided a rationale to understand the conflicting epidemiological observations between the studies on the 677C-T and 1298A-C MTHFR polymorphic variants, and the risk of having an infant with Down syndrome (DS). Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 69-74 18560705-8 2008 In this regard, we recommend the administration of folic acid in women in search of pregnancy due to the high frequency of heterozygous and homozygous for MTHFR C677T mutation in our population. Folic Acid 51-61 methylenetetrahydrofolate reductase Homo sapiens 155-160 18180190-9 2008 Among males, those with the MTHFR 677TT genotype appear to be at the highest risk and to be the most vulnerable to factors (e.g. smoking, low RBC folate) that are associated with homocysteine raising effects. Folic Acid 146-152 methylenetetrahydrofolate reductase Homo sapiens 28-33 18162478-1 2008 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the metabolism of folate, whose role in gastric carcinogenesis is controversial. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 18074111-3 2008 A common mutation (677C-->T) in the gene coding for MTHFR has been reported to reduce the enzymatic activity and is associated with elevated levels of Hcy, especially in subjects with low folate intake. Folic Acid 191-197 methylenetetrahydrofolate reductase Homo sapiens 55-60 18174236-3 2008 Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase (TS), influence folate metabolism, but epidemiological studies have yielded inconsistent findings. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 111-116 18174236-8 2008 In combination analysis, a significantly elevated OR was found among postmenopausal women with the MTHFR 677TT genotype and lower intake of dietary folate compared with those with 677CC genotype and adequate folate consumption (OR = 2.80, 95% CI: 1.11-7.07). Folic Acid 148-154 methylenetetrahydrofolate reductase Homo sapiens 99-104 18070159-1 2008 BACKGROUND: A recent study suggested a link between folate metabolism and atopy, based on a positive association between a common polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and allergic sensitization in Danish adults. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 150-185 18070159-1 2008 BACKGROUND: A recent study suggested a link between folate metabolism and atopy, based on a positive association between a common polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and allergic sensitization in Danish adults. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 187-192 18245544-8 2008 MTHFR c.677 influenced pretreatment homocysteine (P < 0.05) and serum folate levels (P < 0.05). Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 0-5 18245544-11 2008 In addition, MTHFR single nucleotide polymorphisms predicted serum folate and plasma homocysteine levels, and, combined, these factors may be important predictors of capecitabine-induced toxicity. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 13-18 17963764-6 2008 The MTHFR T677T genotype increased the risk for placental abruption 4.8 times despite folate supplements, and normal serum folate and B(12) levels. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 4-9 17963764-6 2008 The MTHFR T677T genotype increased the risk for placental abruption 4.8 times despite folate supplements, and normal serum folate and B(12) levels. Folic Acid 123-129 methylenetetrahydrofolate reductase Homo sapiens 4-9 18605945-1 2008 BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 18409008-1 2008 5,10-methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in folate metabolism. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 19075497-3 2008 This study aimed to assess the effect of folic acid supplementation quantitatively in MTHFR haplotypes, and compare its prediction power with that of the C677T single nucleotide polymorphism (SNP) alone. Folic Acid 41-51 methylenetetrahydrofolate reductase Homo sapiens 86-91 17976958-2 2008 Reduced methylenetetrahydrofolate reductase (MTHFR) activity, resulting in aberrant folate metabolism and hyperhomocysteinemia, has been linked to cardiovascular disease and is unstudied in relation to AAP associated metabolic complications. Folic Acid 27-33 methylenetetrahydrofolate reductase Homo sapiens 45-50 19172696-2 2008 In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C > T polymorphism, which were analysed in a previous study. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 286-291 18804702-6 2008 In this chapter, we consider the role that MTHFR plays in relation to folate metabolism and the possible contribution made in relation to certain important clinical outcomes. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 43-48 19424840-1 2007 The homocysteine level is considered to be a product of genetic and lifestyle interactions, mainly mutated methylenetetrahydrofolate reductase (MTHFR) and the intake of folate, vitamin B12 and pyridoxine, and their blood levels. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 144-149 18194124-2 2007 The drug exerts its effect on folate metabolism; 5,10-methylenetetrahydrofolate reductase is a critical enzyme involved in this cycle and is related to the toxicity of methotrexate. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 54-89 17972183-1 2007 Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the metabolism of folate, which provides a methyl donor for DNA methylation and deoxynucleoside synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 18034620-2 2007 Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and has been shown to be polymorphic, affecting the enzyme activity. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 18034620-6 2007 CONCLUSION: The results of our study suggest that the MTHFR 677T and 1298C alleles may be associated with an increased rate of RA remission in patients treated with MTX receiving high doses of folic acid supplementation. Folic Acid 193-203 methylenetetrahydrofolate reductase Homo sapiens 54-59 18195462-3 2007 Methylenetetrahydrofolate reductase (MTHFR) is involved in the folate metabolism and has been shown to be polymorphic what affects the enzyme activity. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 17711493-2 2007 5,10-Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and its C677T polymorphism may be more prevalent in migraine. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 17891601-9 2007 It may be postulated that the risk of higher MTX toxicity in patients with decreased MTHFR activity could be neutralized by the normally folate rich diet in Mexico. Folic Acid 137-143 methylenetetrahydrofolate reductase Homo sapiens 85-90 17927652-0 2007 Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms. Folic Acid 12-22 methylenetetrahydrofolate reductase Homo sapiens 75-80 17927652-3 2007 We supplemented 16 children with migraine, hyperhomocysteinemia, and MTHFR polymorphisms with folic acid and obtained a resolution/reduction of migraine attacks. Folic Acid 94-104 methylenetetrahydrofolate reductase Homo sapiens 69-74 17418558-0 2007 Red blood cell folate vitamer distribution in healthy subjects is determined by the methylenetetrahydrofolate reductase C677T polymorphism and by the total folate status. Folic Acid 15-21 methylenetetrahydrofolate reductase Homo sapiens 84-119 17418558-14 2007 In addition, high total folate status may contribute to minor to moderate nonmethylfolate accumulation in MTHFR CC and CT subjects. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 106-111 18033026-7 2007 The treatment of CBS deficiency depends on vitamin B6, whereas MTHFR deficiency can be efficiently treated by vitamin B12, folic acid, and betaine. Folic Acid 123-133 methylenetetrahydrofolate reductase Homo sapiens 63-68 17702010-1 2007 We recently observed an association between combinations of polymorphisms in the methylenetetrahydrofolate reductase (MTHFR 677C > T or 1298A > C) and reduced folate carrier (RFC-1 80G > A) genes and the risk of a Down syndrome (DS) pregnancy in young Italian women. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 118-123 17970089-1 2007 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 17970089-2 2007 Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the MTHFR gene could modify the susceptibility to cancer. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 8-13 17970089-2 2007 Because MTHFR is a key enzyme in folate metabolism, changes in its activity resulting from polymorphisms in the MTHFR gene could modify the susceptibility to cancer. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 112-117 17436311-7 2007 We confirmed the strong associations of MTHFR c.665C>T with tHcy and folate, but also observed significant (P<0.01) changes in metabolite concentrations according to other gene polymorphisms. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 40-45 17602711-6 2007 The protective effect of the homozygous variant TT form of the MTHFR genotype (C677T) on the risk of colorectal cancer seems to be modified by the level of methyl diets, that is, by folate, which has a protective effect, or conversely by alcohol. Folic Acid 182-188 methylenetetrahydrofolate reductase Homo sapiens 63-68 17602711-7 2007 Recommendation of higher intake of folate and lower intake of alcohol to the target population, especially those with TT genotype of MTHFR, may be an effective preventive approach against colorectal cancer. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 133-138 17468511-2 2007 Functional polymorphisms in genes encoding one-carbon metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR C677T and A1,298C), methionine synthase (MTR A2,756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase, influence folate metabolism and thus might be suspected of impacting on lung cancer risk. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 111-116 17574963-3 2007 Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are enzymes that play central roles in the folate metabolic pathway. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 17687709-3 2007 METHOD: The physiology of the one-carbon cycle, involving folate, cobalamin, homocysteine, S-adenosyl-methionine, and methylene tetrahydrofolate reductase (MTHFR) is first reviewed, and then the particular contributions of folate and B12 are reviewed. Folic Acid 138-144 methylenetetrahydrofolate reductase Homo sapiens 156-161 17111187-2 2007 The methylenetetrahydrofolate reductase (MTHFR) gene, involved in folate metabolism, is polymorphic in humans. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 17412321-1 2007 We have examined the prevalence of the C677T and A1298C single nucleotide polymorphisms (SNPs) in the methylenetetrahydrofolate reductase (MTHFR) gene in healthy Tamilians and in patients with acute myocardial infarction and related this polymorphism to plasma homocysteine concentrations, serum folate, serum cobalamin and riboflavin status. Folic Acid 121-127 methylenetetrahydrofolate reductase Homo sapiens 139-144 17436239-1 2007 Folates are carriers of one-carbon units and are metabolized by 5,10-methylenetetrahydrofolate reductase (MTHFR) and other enzymes that use riboflavin, cobalamin, or vitamin B6 as cofactors. Folic Acid 0-7 methylenetetrahydrofolate reductase Homo sapiens 64-104 17436239-1 2007 Folates are carriers of one-carbon units and are metabolized by 5,10-methylenetetrahydrofolate reductase (MTHFR) and other enzymes that use riboflavin, cobalamin, or vitamin B6 as cofactors. Folic Acid 0-7 methylenetetrahydrofolate reductase Homo sapiens 106-111 17440589-1 2007 OBJECTIVE: To study the relationship between 5,10-methylenetetrahydrofolate reductase(MTHFR) genetic polymorphism and arsenic metabolism and the role of folate in it. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 86-91 17301815-1 2007 The homozygous mutation (677TT) in the methylenetetrahydrofolate reductase (MTHFR) gene reduces enzyme activity and alters cellular folate composition. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 76-81 17301815-5 2007 MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 0-5 17301815-5 2007 MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 0-5 17301815-5 2007 MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction. Folic Acid 127-134 methylenetetrahydrofolate reductase Homo sapiens 0-5 17301815-5 2007 MTHFR TT genotype significantly reduced folate-dependent remethylation under folate restriction, reflecting limited methylated folates under folate restriction. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 0-5 17523926-8 2007 CONCLUSION: Polymorphisms in methylenetetrahydrofolate reductase are potentially correctable with folic acid supplementation; however, further evaluation is required in adequately powered prospective clinical trials. Folic Acid 98-108 methylenetetrahydrofolate reductase Homo sapiens 29-64 17245555-1 2007 Little is known about the contribution of polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and the folate metabolism pathway in rectal cancer alone. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 105-110 17349292-1 2007 Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate and homocysteine metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 17588738-1 2008 Numerous studies have reported a relationship between folate status, the methylenetetrahydrofolate reductase (MTHFR) 677C-->T variant and disease risk. Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 110-115 17588738-9 2008 The response of phosphatidylcholine to folate intake appeared to be influenced by MTHFR C677T genotype. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 82-87 18053312-0 2008 Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 58-63 18053312-0 2008 Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 21-56 18053312-0 2008 Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 58-63 18053808-0 2008 Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels. Folic Acid 125-131 methylenetetrahydrofolate reductase Homo sapiens 87-92 18053808-4 2008 RESULTS: The non-wild type allele of SLC19A1 polymorphism -43T>C was associated with low red cell folate levels and the non-wild type allele of MTHFR polymorphism 677C>T with low plasma folate levels. Folic Acid 186-192 methylenetetrahydrofolate reductase Homo sapiens 144-149 18053808-5 2008 CONCLUSION: SLC19A1 and MTHFR genes are differently associated with red cell and plasma folate levels. Folic Acid 88-94 methylenetetrahydrofolate reductase Homo sapiens 24-29 18714149-8 2008 Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09-10.73) ng/ml serum folate, 7.57 (4.94-12.94) micromol/l homocysteine; homozygous 4.10 (2.75-7.88) ng/ml serum folate, 10.83 (7.00-22.82) micromol/l homocysteine. Folic Acid 139-145 methylenetetrahydrofolate reductase Homo sapiens 43-78 18714149-8 2008 Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09-10.73) ng/ml serum folate, 7.57 (4.94-12.94) micromol/l homocysteine; homozygous 4.10 (2.75-7.88) ng/ml serum folate, 10.83 (7.00-22.82) micromol/l homocysteine. Folic Acid 139-145 methylenetetrahydrofolate reductase Homo sapiens 43-78 18586656-2 2008 The aim of this study was to investigate the relations between the methylenetetrafolate reductase (MTHFR) 677C-->T genotypes, B-vitamins (folate, vitamin B-12 and B-6), homocysteine and the risk of CAD. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 99-104 17543893-12 2008 Further, the biochemical interaction of low serum folate with 677T-variant MTHFR may induce downstream effects salient to the expression of negative symptoms. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 75-80 18022874-2 2008 The mutations on two genes involved in folate metabolism, the C677 of the MTHFR gene and the RFC-1(A80G) gene are potential risk factors of NTDs. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 74-79 18406541-2 2008 Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 66-101 18406541-2 2008 Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 103-108 18406541-2 2008 Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers. Folic Acid 85-91 methylenetetrahydrofolate reductase Homo sapiens 103-108 18160726-1 2008 BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR). Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 66-71 18160726-1 2008 BACKGROUND: The 5,10-methylenetetrahydrofolate reductase (NADPH) (MTHFR) C677T polymorphism may affect whole-blood folate pattern measured by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and total folate measured by LC-MS/MS, microbiologic assay, and Bio-Rad radioassay (BR). Folic Acid 115-121 methylenetetrahydrofolate reductase Homo sapiens 66-71 18160726-9 2008 CONCLUSION: MTHFR C677T polymorphism influences the folate pattern in whole blood. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 12-17 18473861-7 2008 We also present our work on the development of a novel anti-cancer target, methylenetetrahydrofolate reductase (MTHFR), a key enzyme of both folate and methionine metabolism. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 112-117 18957721-8 2008 Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population. Folic Acid 106-112 methylenetetrahydrofolate reductase Homo sapiens 33-38 18957721-8 2008 Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population. Folic Acid 106-112 methylenetetrahydrofolate reductase Homo sapiens 88-93 19096127-2 2008 With the purpose of evaluating this relationship, we compared the frequencies of 677C>T and 1298A>C polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR) and 66A>G in the methionine synthase reductase gene (MTRR) between 103 young mothers of Down syndrome (DS) individuals and 108 control mothers, whose offspring was karyotypically normal, correlating it with an estimative of folate and - related micronutrients levels intake. Folic Acid 146-152 methylenetetrahydrofolate reductase Homo sapiens 169-174 17725378-1 2008 UNLABELLED: The MTHFR C677T polymorphism is associated with mildly elevated homocysteine levels when folate and/or riboflavin status is low. Folic Acid 101-107 methylenetetrahydrofolate reductase Homo sapiens 16-21 17725378-5 2008 INTRODUCTION: The MTHFR C677T polymorphism is associated with mildly elevated homocysteine (Hcy) levels in the presence of low folate and/or riboflavin status. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 18-23 18480590-0 2008 Serum folate and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism adjusted for folate intake. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 18480590-1 2008 BACKGROUND: Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 72-107 18480590-1 2008 BACKGROUND: Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 109-114 18480590-1 2008 BACKGROUND: Serum folate concentration is lower in individuals with the methylenetetrahydrofolate reductase (MTHFR) 677TT genotype than in those with the MTHFR 677CC or 677CT genotypes. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 154-159 18156406-1 2008 Since the establishment of the 1998 folate recommended dietary allowance (RDA), the methylenetetrahydrofolate reductase (MTHFR) 677C-->T variant has emerged as a strong modifier of folate status. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 84-119 18156406-1 2008 Since the establishment of the 1998 folate recommended dietary allowance (RDA), the methylenetetrahydrofolate reductase (MTHFR) 677C-->T variant has emerged as a strong modifier of folate status. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 121-126 18156406-1 2008 Since the establishment of the 1998 folate recommended dietary allowance (RDA), the methylenetetrahydrofolate reductase (MTHFR) 677C-->T variant has emerged as a strong modifier of folate status. Folic Acid 103-109 methylenetetrahydrofolate reductase Homo sapiens 121-126 19918112-0 2008 Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 51-56 19918112-3 2008 We show that historically, the seasonal cycle of abundance of folate-rich foods may have regulated embryo viability by acting as a selection factor for a significant polymorphism within a gene encoding 5,10-methylenetetrahydrofolate reductase (677C-->T-MTHFR). Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 256-261 19172696-2 2008 In this nested case-referent study, we related two such polymorphisms, reduced folate carrier (RFC1) 80G > A and folate hydrolase 1 (FOLH1) 1561C > T, to the risk of colorectal cancer, taking into account pre-diagnostic plasma folate and total homocysteine concentrations and the MTHFR 677C > T polymorphism, which were analysed in a previous study. Folic Acid 116-122 methylenetetrahydrofolate reductase Homo sapiens 286-291 17712558-2 2007 Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one carbon metabolism of deoxyribonucleic acid (DNA) synthesis and methylation; both are implicated in carcinogenesis of many types of cancer including lymphoma. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 17965089-2 2007 Identification of candidate genes in folate metabolism has suggested that the 677C-->T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene may be particularly associated with the risk of CHDs. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 110-145 17965089-2 2007 Identification of candidate genes in folate metabolism has suggested that the 677C-->T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene may be particularly associated with the risk of CHDs. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 147-152 18006931-1 2007 Previous studies have shown inconsistent associations of folate intake and polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene with gastric cancer risk. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 133-138 17904970-11 2007 Plasma homocysteine and vitamin B12, but not folate, concentrations were elevated in cases compared with control subjects among women with the wild-type genotype of MTHFR 677C-->T (P = .039 for homocysteine; P = .048 for B12; P = .224 for folate). Folic Acid 242-248 methylenetetrahydrofolate reductase Homo sapiens 165-170 17561949-3 2007 Four MTHFR polymorphism groups were identified with the following tHcy (micromol/L) and folate (nmol/L) levels (mean +/- SD): (a) MTHFR677TT/1298AA, 24 patients, 36.0 +/- 4.8, 4.1 +/- 0.7; (b) MTHFR677CT/1298AC 27.1 +/- 2.7, 5.3 +/- 1.0 (n = 15); (c) MTHFR677CT/1298AA 16.6 +/- 3.6, 6.8 +/- 1.0 (n = 11), all taking enzyme-inducing AEDs; and (d) MTHFR677TT/1298AA 24.5 +/- 3.2, 5.6 +/- 1.1 (n = 9), treated with new AEDs. Folic Acid 88-94 methylenetetrahydrofolate reductase Homo sapiens 5-10 17922421-1 2007 OBJECTIVE: To investigate whether the polymorphism in methylenetetrahydrofolate reductase (MTHFR) gene involved in folate metabolism is associated with Down syndrome (DS). Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 91-96 17596206-2 2007 Functional polymorphisms in genes encoding one-carbon metabolism enzymes, such as methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MTR A2756G), methionine synthase reductase (MTRR A66G) and thymidylate synthase (TS), influence folate metabolism and thus might impact on HNSCC risk. Folic Acid 101-107 methylenetetrahydrofolate reductase Homo sapiens 119-124 17709451-1 2007 Adequate folate availability is necessary to sustain normal DNA synthesis and normal patterns of DNA methylation and these features of DNA can be modified by methylenetetrahydrofolate reductase (MTHFR) C677T genotype. Folic Acid 9-15 methylenetetrahydrofolate reductase Homo sapiens 158-193 17709451-1 2007 Adequate folate availability is necessary to sustain normal DNA synthesis and normal patterns of DNA methylation and these features of DNA can be modified by methylenetetrahydrofolate reductase (MTHFR) C677T genotype. Folic Acid 9-15 methylenetetrahydrofolate reductase Homo sapiens 195-200 17156840-1 2007 Methylenetetrahydrofolate reductase (MTHFR) is an enzyme involved in folate metabolism and DNA methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 17451848-9 2007 Search and prevention of potential risk factors are required in all patients; determination of MTHFR genotype may be of several interests as folate supplementation. Folic Acid 141-147 methylenetetrahydrofolate reductase Homo sapiens 95-100 17704422-1 2007 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating intracellular folate levels, which affects DNA synthesis and methylation. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 17621650-1 2007 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) of the folate metabolism pathway is a candidate gene for neural tube defects (NTDs). Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 17228344-9 2007 However, with stratification by mean value of age and B-group vitamins concentrations, we found that at advanced age, lower plasma folate and vitamin B(12) were three risk factors involved in the enhancing effect of the MTHFR 677TT genotype on the increase of plasma Hcy and carotid IMT. Folic Acid 131-137 methylenetetrahydrofolate reductase Homo sapiens 220-225 17228344-10 2007 CONCLUSION: MTHFR 677TT-related carotid atherosclerosis was only identified in healthy elderly subjects with lower level of plasma folate and vitamin B(12). Folic Acid 131-137 methylenetetrahydrofolate reductase Homo sapiens 12-17 17591934-1 2007 The disorders of folate metabolism caused by methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms may lead to several disease states including coronary heart disease, venous thrombosis, and several types of cancer. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 45-80 17591934-1 2007 The disorders of folate metabolism caused by methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms may lead to several disease states including coronary heart disease, venous thrombosis, and several types of cancer. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 82-87 17457696-8 2007 This study indicates that the sequence alteration c.677C>T combined with severe MTHFR mutations in compound heterozygous state may lead to moderate biochemical and clinical abnormalities exceeding those attributed to the c.677TT genotype and might require in addition to folate substitution further therapy to normalize homocysteine levels. Folic Acid 274-280 methylenetetrahydrofolate reductase Homo sapiens 83-88 17436239-6 2007 Conversely, the MTHFR polymorphism influenced B vitamin effects, which were strongest in the TT group, in which the estimated tHcy difference between subjects with vitamin concentrations in the lowest compared with the highest quartile was 5.4 micromol/liter for folate, 4.1 micromol/liter for riboflavin, 3.2 micromol/liter for cobalamin, and 2.1 micromol/liter for vitamin B6. Folic Acid 263-269 methylenetetrahydrofolate reductase Homo sapiens 16-21 17445539-9 2007 The present data indicate an association between homocysteine and BAFMD and reduced BAFMD in individuals with the MTHFR nucleotide 677 T/T genotype, despite similar blood values for folate and homocysteine. Folic Acid 182-188 methylenetetrahydrofolate reductase Homo sapiens 114-119 17245555-0 2007 Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 62-67 17303386-10 2007 CONCLUSION: A further inactivation of polymorphic MTHFR by low riboflavin status and a resulting shift in the folate metabolic pathway toward DNA synthesis may explain these observations. Folic Acid 110-116 methylenetetrahydrofolate reductase Homo sapiens 50-55 17219389-2 2007 The methylenetetrahydrofolate reductase gene (MTHFR) plays a major role in folate metabolism, and several polymorphisms, including C677T, are common in European populations. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 46-51 17227731-2 2007 METHODS: We evaluated homocysteine, folic acid and vitamin B(12) concentrations, and the mutations 677C>T and 1298A>C in MTHFR, 844ins68 in CBS and 2756A>G in MTR genes in 58 patients with congenital heart defects, 38 control subjects, and mothers of 49 patients and 26 controls. Folic Acid 36-46 methylenetetrahydrofolate reductase Homo sapiens 127-132 17053001-2 2007 Methylenetetrahydrofolate reductase (MTHFR) regulates the flow of folic acid-derived, one-carbon moieties for methylation and is critical to early embryonic development. Folic Acid 66-76 methylenetetrahydrofolate reductase Homo sapiens 0-35 17053001-2 2007 Methylenetetrahydrofolate reductase (MTHFR) regulates the flow of folic acid-derived, one-carbon moieties for methylation and is critical to early embryonic development. Folic Acid 66-76 methylenetetrahydrofolate reductase Homo sapiens 37-42 17074966-7 2007 This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention. Folic Acid 170-176 methylenetetrahydrofolate reductase Homo sapiens 59-64 17011719-11 2007 The role of homocysteine and the vitamin B-complex, especially folic acid, in these changes in DNA transcription would vary according to the polymorphism of the methylenetetrahydrofolate reductase gene. Folic Acid 63-73 methylenetetrahydrofolate reductase Homo sapiens 161-196 18167510-3 2007 The methylenetetrahydrofolate reductase (MTHFR) 677C-->T variant is an important determinant of folate nutriture and may influence DNA methylation. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 18167510-8 2007 However, at the end of folate treatment (wk 14), DNA methylation was lower (P<0.05) in women with the MTHFR 677TT genotype relative to the CT or CC genotype. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 105-110 17607914-3 2007 In esophageal carcinomas, a higher gene expression of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, was more frequently found in responding patients. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 91-96 16944145-1 2006 Methylenetetrahydrofolate reductase (MTHFR) is one of the most critical enzyme in folic acid metabolism, and it converts 5,10-MTHF to 5-MTHF. Folic Acid 82-92 methylenetetrahydrofolate reductase Homo sapiens 0-35 16944145-1 2006 Methylenetetrahydrofolate reductase (MTHFR) is one of the most critical enzyme in folic acid metabolism, and it converts 5,10-MTHF to 5-MTHF. Folic Acid 82-92 methylenetetrahydrofolate reductase Homo sapiens 37-42 16944145-5 2006 Because folate is the cornerstone in DNA synthesis, we analysed herein if the polymorphisms in MTHFR gene can alter the susceptibility of lymphoproliferative disease risk and if it has an effect on chemotherapy response. Folic Acid 8-14 methylenetetrahydrofolate reductase Homo sapiens 95-100 17243563-1 2006 The aim of the study was to investigate the association between methylenetetrahydrofolate (MTHFR) genotypes and levels of homocysteine (Hcy), folate, vitamin B12 and lipids as well as the association between apolipoprotein E (apo E) genotypes and levels of lipids in a Croatian healthy control group and a group of patients with > 70% carotid stenosis (CS). Folic Acid 83-89 methylenetetrahydrofolate reductase Homo sapiens 91-96 17087956-1 2006 BACKGROUND & AIMS: Methylenetetrahydrofolate reductase (MTHFR) is involved in intracellular folate homeostasis and metabolism. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 60-65 17087956-2 2006 We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status. Folic Acid 203-209 methylenetetrahydrofolate reductase Homo sapiens 35-40 17087956-8 2006 CONCLUSIONS: We propose that the effect of the MTHFR genotypes on increasing risk of adenoma recurrence in the presence of a low folate status is through their increase in homocysteine concentrations, which in turn could result in DNA hypomethylation via pathways involving S-adenosylhomocysteine. Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 47-52 16861746-1 2006 BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 57-92 16861746-1 2006 BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 94-99 16997330-0 2006 Influence of DNA repair gene polymorphisms of hOGG1, XRCC1, XRCC3, ERCC2 and the folate metabolism gene MTHFR on chromosomal aberration frequencies. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 104-109 16997330-1 2006 We have studied the effect of genetic polymorphisms in the DNA repair genes hOGG1, XRCC1, XRCC3, ERCC2 and the MTHFR gene in the folate metabolism on the frequencies of cells with chromosomal aberrations (CA), chromosome-type aberrations (CSA), chromatid-type aberrations (CTA), chromatid breaks (CTB) and chromatid gaps (CTG) scored in peripheral blood lymphocytes from 651 Norwegian subjects of Caucasian descendant. Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 111-116 16936070-3 2006 Low folate status in pregnant women has been implicated in several congenital malformations, and folate metabolism may be affected by polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR). Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 197-202 16936070-3 2006 Low folate status in pregnant women has been implicated in several congenital malformations, and folate metabolism may be affected by polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR). Folic Acid 97-103 methylenetetrahydrofolate reductase Homo sapiens 155-190 16936070-3 2006 Low folate status in pregnant women has been implicated in several congenital malformations, and folate metabolism may be affected by polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR). Folic Acid 97-103 methylenetetrahydrofolate reductase Homo sapiens 197-202 17201138-1 2006 BACKGROUND: 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation; thymidylate synthase (TS) is a rate-limiting enzyme in the synthesis of dTMP and DNA repair. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 16777985-1 2006 Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both are implicated in carcinogenesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 16777985-3 2006 To evaluate the C677T and A1298C functional polymorphisms in the MTHFR gene and their associations with breast cancer risk, as well as the potential modifying effect by plasma folate status on the MTHFR-associated risk, a hospital-based case-control study was conducted on a Taiwanese population consisting of 146 histologically confirmed incident breast cancer cases and their 285 age-matched controls without a history of cancer. Folic Acid 176-182 methylenetetrahydrofolate reductase Homo sapiens 197-202 16524711-5 2006 Serum folate (P=.065) and RBC folate (P=.022) concentrations were lower and plasma tHcy was higher (P=.039) in women with the MTHFR 677 TT genotype relative to the CC genotype. Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 126-131 16524711-5 2006 Serum folate (P=.065) and RBC folate (P=.022) concentrations were lower and plasma tHcy was higher (P=.039) in women with the MTHFR 677 TT genotype relative to the CC genotype. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 126-131 16524711-7 2006 These data suggest that a doubling of food folate intake will lead to marked improvements in folate status in women with the MTHFR 677 CC or TT genotype. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 125-130 16524711-7 2006 These data suggest that a doubling of food folate intake will lead to marked improvements in folate status in women with the MTHFR 677 CC or TT genotype. Folic Acid 93-99 methylenetetrahydrofolate reductase Homo sapiens 125-130 17030196-2 2006 We conducted a systematic review with meta-analysis of epidemiologic studies evaluating the association of folate intake or genetic polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, with risk of esophageal, gastric, or pancreatic cancer. Folic Acid 173-179 methylenetetrahydrofolate reductase Homo sapiens 191-196 16646054-5 2006 We also investigated the association of methylation silencing with functional polymorphisms in the folate metabolism enzyme methylene tetrahydrofolate reductase (MTHFR). Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 162-167 16646054-7 2006 Furthermore, this increased risk for epigenetic silencing at p16(INK4A) was modified by the MTHFR alleles previously associated with diminished serum folate levels. Folic Acid 150-156 methylenetetrahydrofolate reductase Homo sapiens 92-97 16646054-8 2006 Hence, in HNSCC low dietary intake of folate is associated with p16(INK4A) methylation, and this relationship is modified by the MTHFR genotype. Folic Acid 38-44 methylenetetrahydrofolate reductase Homo sapiens 129-134 16936384-1 2006 BACKGROUND AND AIMS: In view of the prevailing controversy about the role of Methylenetetrahydrofolate reductase (MTHFR) C677T mutation in stroke and paucity of studies from India, this study has been undertaken to evaluate MTHFR C677T gene polymorphism in consecutive ischemic stroke patients and correlate these with folic acid, homocysteine (Hcy) and conventional risk factors. Folic Acid 319-329 methylenetetrahydrofolate reductase Homo sapiens 114-119 16953277-12 2006 Carriers of the methylenetetrahydrofolate reductase (MTHFR) 677T allele with CAD had significantly higher levels of anti-Nepsilon-Hcy-albumin before and during folic acid administration as compared to healthy subjects. Folic Acid 160-170 methylenetetrahydrofolate reductase Homo sapiens 16-51 16953277-12 2006 Carriers of the methylenetetrahydrofolate reductase (MTHFR) 677T allele with CAD had significantly higher levels of anti-Nepsilon-Hcy-albumin before and during folic acid administration as compared to healthy subjects. Folic Acid 160-170 methylenetetrahydrofolate reductase Homo sapiens 53-58 16602006-7 2006 They found that the mother, who also had not supplemented her folic acid intake, had a secondarily altered folate status with an increased homocysteine level, suggesting that the homozygous TT mutation in the MTHFR gene in both mother and her child had contributed to the presentation of DS and a neural tube defect. Folic Acid 107-113 methylenetetrahydrofolate reductase Homo sapiens 209-214 16602006-12 2006 that the MTHFR 677TT could be a mutual genetic risk factor for the co-occurrence of trisomy 21 and midline defects, the risk of which may be reduced by periconceptional folic acid supplementation. Folic Acid 169-179 methylenetetrahydrofolate reductase Homo sapiens 9-14 16865747-10 2006 Hyperhomocysteinemia and the vitamin deficiencies presented by type 2 diabetic individuals, included with a heterozygous genotype for the G1793A mutation in the MTHFR gene, reached normal values by daily folic acid supplementation. Folic Acid 204-214 methylenetetrahydrofolate reductase Homo sapiens 161-166 16541270-1 2006 BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 91-125 16541270-1 2006 BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 127-132 16541270-1 2006 BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 91-125 16541270-1 2006 BACKGROUND: Low folate intake and changes in folate metabolism due to polymorphisms in the methylentetrahydrofolate reductase (MTHFR) gene have been associated with myelomagenesis. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 127-132 16541270-9 2006 CONCLUSIONS: Our data demonstrated that variant alleles did not play a key role neither in protection nor in increased risk for MM, suggesting that the effect of MTHFR on folate metabolism might be modified by diet intake. Folic Acid 171-177 methylenetetrahydrofolate reductase Homo sapiens 162-167 16410450-2 2006 Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism, including methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS or MTR), serine hydroxymethyltransferase (SHMT), and thymidylate synthase (TS or TYMS), modify the risk of various cancers and possibly FL. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 133-138 16690736-4 2006 Serum folate concentrations were related to MTHFR 677 TT genotype in persons with folate intake in the lowest tertile (< 221.2 microg/day). Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 44-49 16690736-4 2006 Serum folate concentrations were related to MTHFR 677 TT genotype in persons with folate intake in the lowest tertile (< 221.2 microg/day). Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 44-49 16450391-3 2006 We have previously observed a protective effect of maternal folate supplementation during pregnancy against ALL, and a number of studies have reported protective effects of some common polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 243-248 16450391-4 2006 One study has suggested that the effect of MTHFR polymorphisms on risk of ALL may depend on folate status. Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 43-48 16418743-12 2006 Supplementation of folic acid with vitamin B(12) may be preferable when the MTHFR 677T variant allele is prevalent. Folic Acid 19-29 methylenetetrahydrofolate reductase Homo sapiens 76-81 16596679-2 2006 The 80G>A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the 677C>T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Folic Acid 41-47 methylenetetrahydrofolate reductase Homo sapiens 212-247 16596679-2 2006 The 80G>A polymorphism of the reduced folate carrier gene (RFC-1) has been recently demonstrated to affect plasma folate and homocysteine levels, alone or in combination with the 677C>T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene. Folic Acid 41-47 methylenetetrahydrofolate reductase Homo sapiens 249-254 16641680-7 2006 These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 145-180 16575899-0 2006 Maternal polymorphisms 677C-T and 1298A-C of MTHFR, and 66A-G MTRR genes: is there any relationship between polymorphisms of the folate pathway, maternal homocysteine levels, and the risk for having a child with Down syndrome? Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 45-50 16821630-1 2006 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a role in DNA biosynthesis, methylation and repair in actively dividing cells by acting on folate metabolism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 16681562-16 2006 Genotypic characteristics suggest that C(677)T MTHFR mutation confers a higher risk for stroke to both homozygous and heterozygous T allele carriers that cannot be ascribed solely to raised tHcy and/or lower folate status in CT subjects, nor to phenotypic expression of conventional risk factors for stroke. Folic Acid 208-214 methylenetetrahydrofolate reductase Homo sapiens 47-52 16672082-3 2006 Since the identification of the first genetic risk factor of NTD, the C677T single-nucleotide polymorphism (SNP) in the methylenetetrahydrofolate reductase (MTHFR) gene, and the observation that elevated plasma homocysteine levels are associated with NTD, research has focused on genetic variation in genes encoding for enzymes of folate metabolism and the closely-related homocysteine metabolism. Folic Acid 139-145 methylenetetrahydrofolate reductase Homo sapiens 157-162 16796406-11 2006 Anyway, we suggest that, because of the high prevalence of the mutation MTHFR C677T found, screening should be made in the thombophilia studies, so that we could find patients with a risk factor that could be lowered by folates in the diet. Folic Acid 220-227 methylenetetrahydrofolate reductase Homo sapiens 72-77 16518429-2 2006 A critical enzyme involved in folate metabolism is 5,10-methylenetetrahydrofolate reductase (MTHFR). Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 51-91 16518429-2 2006 A critical enzyme involved in folate metabolism is 5,10-methylenetetrahydrofolate reductase (MTHFR). Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 93-98 16612468-2 2006 The C677T polymorphism for the gene that encodes the methylenetetrahydrofolate reductase enzyme (MTHFR) and low plasma folate levels are common causes of hyperhomocystinemia. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 97-102 16524890-0 2006 Maternal MTHFR 677C>T is a risk factor for congenital heart defects: effect modification by periconceptional folate supplementation. Folic Acid 112-118 methylenetetrahydrofolate reductase Homo sapiens 9-14 16524890-2 2006 The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 78-113 16524890-2 2006 The search for candidate genes involved in the folate metabolism includes the methylenetetrahydrofolate reductase (MTHFR) 677C > T polymorphism. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 115-120 16524890-8 2006 In a case-only study, the interaction between periconceptional folate supplementation and maternal MTHFR genotype was significant (P = 0.012). Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 99-104 16522921-2 2006 OBJECTIVE: We examined the interactions and associations with serum total homocysteine (tHcy) and folate concentrations of polymorphisms in the following folate-metabolizing genes: methylenetetrahydrofolate reductase (MTHFR), reduced folate carrier 1 (RFC1), and glutamate carboxypeptidase II (GCPII). Folic Acid 154-160 methylenetetrahydrofolate reductase Homo sapiens 181-216 16522921-5 2006 RESULTS: Subjects with the MTHFR 677TT genotype had higher serum tHcy concentrations than did those with the MTHFR 677CC genotype (P < 0.001), and this effect was greater in subjects with low serum folate status (P for interaction = 0.026). Folic Acid 201-207 methylenetetrahydrofolate reductase Homo sapiens 27-32 16464657-5 2006 When folate status was below the median, 5,10-methylenetetrahydrofolate reductase (MTHFR) 677TT homozygotes had similar hearing levels to subjects with a C allele. Folic Acid 5-11 methylenetetrahydrofolate reductase Homo sapiens 41-81 16464657-6 2006 However, when folate status was above the median, MTHFR 677TT homozygotes had on an average 5 dB (p = 0.037) and 2.6 dB (p = 0.021) lower PTA-high and PTA-low hearing thresholds, respectively, than the subjects with a 677C allele. Folic Acid 14-20 methylenetetrahydrofolate reductase Homo sapiens 50-55 16464657-7 2006 The relationship between serum folate and hearing thresholds appeared to be dependent on MTHFR 677 genotype (CC, r = 0.13, p = 0.034; TT, r = -0.10, p = 0.291). Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 89-94 16679643-18 2006 Folate levels may modify the presentation of the MTHFR TT genotype. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 49-54 16374229-1 2006 It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate from DNA synthesis and repair to methylation reactions, are involved in the aetiology of cancer. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 65-100 16374229-1 2006 It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate from DNA synthesis and repair to methylation reactions, are involved in the aetiology of cancer. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 102-107 16374229-1 2006 It has been proposed that folate and polymorphisms of the enzyme methylenetetrahydrofolate reductase (MTHFR), which regulates influx of folate from DNA synthesis and repair to methylation reactions, are involved in the aetiology of cancer. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 102-107 16374229-6 2006 Our previously reported observation of a possible increase in the risk of prostate cancer at high plasma folate levels was attributable in this study to subjects having the MTHFR 677C-->T polymorphism. Folic Acid 105-111 methylenetetrahydrofolate reductase Homo sapiens 173-178 16374229-7 2006 We found that the MTHFR 677C-->T polymorphism is not likely to have a major role in the development of prostate cancer, although it may possibly increase the risk in combination with high plasma folate levels. Folic Acid 198-204 methylenetetrahydrofolate reductase Homo sapiens 18-23 16169148-1 2006 Altered maternal folate status and homozygous mutation in the methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes can promote chromosomal instability and non-dysjunction resulting in fetal trisomy 21. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 99-104 16234842-1 2006 OBJECTIVE: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 148-153 16234842-12 2006 CONCLUSIONS: Under conditions of lower folate status (as estimated by either plasma concentration or reported dietary consumption), gender modifies the association of the MTHFR(C677T) polymorphism with tHcy concentrations in healthy children. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 171-176 15935452-0 2006 Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population. Folic Acid 110-116 methylenetetrahydrofolate reductase Homo sapiens 81-86 15935452-2 2006 Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme in homocysteine metabolism; a common C677T mutation in the MTHFR gene results in decreased enzyme activity, and contributes to increased homocysteine levels and decreased folate levels. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 34-39 15935452-2 2006 Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme in homocysteine metabolism; a common C677T mutation in the MTHFR gene results in decreased enzyme activity, and contributes to increased homocysteine levels and decreased folate levels. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 128-133 16353542-4 2005 The prevalence of MTHFR variants (C677T and 677TT) was elevated in all ethnic groups (78% among the wayuu, 76% among Italians and 63% among mestizos) with a significant association between the concentrations of homocysteine and the levels of serum folate among the wayuu (p < 0.0001) and the mestizos (p < 0.001) only. Folic Acid 248-254 methylenetetrahydrofolate reductase Homo sapiens 18-23 16334126-1 2005 BACKGROUND: Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) play important roles in folate metabolism. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 79-84 16370225-2 2005 Recently, functionally significant SNPs in 5,10-methylenetetrahydrofolate reductase (MTHFR), a critical enzyme for intracellular folate homeostasis and metabolism, have been identified and characterized. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 85-90 16370225-3 2005 An emerging body of in vitro and clinical evidence suggests that these MTHFR SNPs may be an important pharmacogenetic determinant of predicting response to and toxicity of methotrexate and 5-fluorouracil-based cancer and anti-inflammatory treatments because of their well-defined and highly relevant biochemical effects on intracellular folate composition and one-carbon transfer reactions. Folic Acid 337-343 methylenetetrahydrofolate reductase Homo sapiens 71-76 16128738-1 2005 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA methylation and synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 16128738-12 2005 Although the underlying mechanisms still remain to be clarified, epidemiological findings regarding MTHFR C677T polymorphism provide strong evidence that adequate folate status confers protection from colorectal cancer. Folic Acid 163-169 methylenetetrahydrofolate reductase Homo sapiens 100-105 16135938-12 2005 CONCLUSION: Maternal and fetal MTHFR C677T polymorphism may be associated with a moderately increased risk of gestational hypertension, and there is a suggestion that this association may be diminished among women receiving folate supplementation during pregnancy. Folic Acid 224-230 methylenetetrahydrofolate reductase Homo sapiens 31-36 16097444-2 2005 Single nucleotide polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene can modulate the effect of folate. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 76-81 16095790-4 2005 Elevated homocysteine is often explained by folate dependency due to mutations in the gene for methylenetetrahydrofolate reductase (MTHFR). Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 95-130 16095790-4 2005 Elevated homocysteine is often explained by folate dependency due to mutations in the gene for methylenetetrahydrofolate reductase (MTHFR). Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 132-137 16103455-1 2005 The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene plays a critical role in folate metabolism. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 16103455-15 2005 Among those with adequate folate intake (>400 microg total folate), we found strong inverse associations between combined MTHFR genotypes and MSI (677 CC+1298 AC/CC, OR, 0.09; 95% CI, 0.01-0.59; 677 CT/TT+1298 AA, OR, 0.13; 95% CI, 0.02-0.85) compared with the combined wild-type genotypes (677 CC+1298 AA). Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 125-130 16103455-15 2005 Among those with adequate folate intake (>400 microg total folate), we found strong inverse associations between combined MTHFR genotypes and MSI (677 CC+1298 AC/CC, OR, 0.09; 95% CI, 0.01-0.59; 677 CT/TT+1298 AA, OR, 0.13; 95% CI, 0.02-0.85) compared with the combined wild-type genotypes (677 CC+1298 AA). Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 125-130 16103455-17 2005 Our results suggest that MTHFR variant genotypes are associated with reduced risk of MSI tumors under conditions of adequate folate intake, although the data are imprecise due to small numbers. Folic Acid 125-131 methylenetetrahydrofolate reductase Homo sapiens 25-30 16103455-18 2005 These results indicate that the relationship between MTHFR genotypes and MSI is influenced by folate status. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 53-58 16043029-0 2005 Uracil misincorporation into DNA of leukocytes of young women with positive folate balance depends on plasma vitamin B12 concentrations and methylenetetrahydrofolate reductase polymorphisms. Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 140-175 16043029-10 2005 The concentration of folate in plasma correlated (P<or=.05) with the wild-type MTHFR homozygote 1298 AA but not with the MTHFR 677 genotype. Folic Acid 21-27 methylenetetrahydrofolate reductase Homo sapiens 82-87 16043029-11 2005 When subjects were grouped according to genotype, the mean concentration of folate in plasma was significantly lower in subjects with the MTHFR 677 (CT+TT) polymorphism, which was accompanied by a lower UrMis, compared to individuals with the CC genotype. Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 138-143 16043029-12 2005 The significantly higher concentrations of folate in serum, accompanied by increased UrMis, were seen in subjects with the combined MTHFR 1298 (AC+CC) genotype, as compared to the 1298 AA wild type. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 132-137 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 85-120 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 122-127 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 330-335 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. Folic Acid 104-110 methylenetetrahydrofolate reductase Homo sapiens 122-127 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. Folic Acid 221-227 methylenetetrahydrofolate reductase Homo sapiens 85-120 16002814-2 2005 Folate metabolism may be altered by alcohol intake and 2 common polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, 677C-->T and 1298A-->C. OBJECTIVE: We examined whether the associations between folate intake and plasma folate and tHcy concentrations were modified by alcohol intake or variations in the MTHFR gene. Folic Acid 221-227 methylenetetrahydrofolate reductase Homo sapiens 122-127 16002818-10 2005 These data support the benefit of folic acid supplementation in pregnant women, particularly in those with MTHFR deficiency. Folic Acid 34-44 methylenetetrahydrofolate reductase Homo sapiens 107-112 15790587-2 2005 Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of impacting on esophageal cancer risk. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 87-92 15790587-5 2005 Folate consumption and MTHFR 677TT were associated with a non-significant tendency for decreased risk while the MTR genotypes did not show any links in themselves; further, when analysis was limited to heavy drinkers, the MTHFR TT genotype significantly decreased esophageal cancer risk [odds ratio (OR) = 0.27, 95% confidence interval (CI), 0.09-0.76]. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 222-227 15941959-1 2005 Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15921520-1 2005 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to conversion of 5,10-methylenetetrahydrofolate (methylene-THF) to 5-methyl-THF. Folic Acid 100-110 methylenetetrahydrofolate reductase Homo sapiens 12-47 15921520-1 2005 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) has a major impact on the regulation of the folic acid pathway due to conversion of 5,10-methylenetetrahydrofolate (methylene-THF) to 5-methyl-THF. Folic Acid 100-110 methylenetetrahydrofolate reductase Homo sapiens 49-54 15688408-1 2005 Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism. Folic Acid 118-124 methylenetetrahydrofolate reductase Homo sapiens 136-141 15729744-3 2005 The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 4-9 15729744-3 2005 The MTHFR gene C677T polymorphism influences folate metabolism and intracellular availability of folate metabolites for methylation. Folic Acid 97-103 methylenetetrahydrofolate reductase Homo sapiens 4-9 15894672-1 2005 Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in the metabolism of folate, a nutrient that has been inversely related to colorectal cancer risk. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15894672-2 2005 The common C677T variant in the MTHFR gene results in a reduced activity of this enzyme, thereby increasing the availability of folate for the production of thymidylate and purine for DNA synthesis and repair. Folic Acid 128-134 methylenetetrahydrofolate reductase Homo sapiens 32-37 15894672-10 2005 This study corroborates previous findings of an inverse association of the MTHFR 677TT genotype with colorectal cancer, especially at high levels of folate and low levels of ethanol intake. Folic Acid 149-155 methylenetetrahydrofolate reductase Homo sapiens 75-80 15867278-8 2005 In conclusion, plasma total homocysteine concentrations in subjects with the MTHFR 677 T/T genotype were inversely related to 5-methyl folate concentrations and directly related to formylated folate concentrations in RBCs, even though the latter were not significantly affected by moderate folate restriction. Folic Acid 135-141 methylenetetrahydrofolate reductase Homo sapiens 77-82 15867278-8 2005 In conclusion, plasma total homocysteine concentrations in subjects with the MTHFR 677 T/T genotype were inversely related to 5-methyl folate concentrations and directly related to formylated folate concentrations in RBCs, even though the latter were not significantly affected by moderate folate restriction. Folic Acid 192-198 methylenetetrahydrofolate reductase Homo sapiens 77-82 15840047-8 2005 CONCLUSION: Higher folate concentrations in kidney transplant recipients with MTHFR 1793GA or 1793AA and markedly higher concentrations of vitamin B(12) in patients with combined MTHFR 1793G>A and 1298A>C mutations may contribute to the survival advantage that has been postulated for such patients showing these genotypes. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 78-83 16011963-1 2005 Plasma homocysteine levels depend in part on the molecular nature of the methylenetetrahydrofolate reductase (MTHFR) and on blood folate intake. Folic Acid 92-98 methylenetetrahydrofolate reductase Homo sapiens 110-115 15726099-3 2005 Methylenetetrahydrofolate reductase (MTHFR 677C --> T and 1298A --> C), methionine synthase (MS 2756A --> G) and cystathionine synthase (CBS 844ins68) polymorphisms were measured to account for potential confounding effects on folate status and DNA methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15548731-2 2005 Within the folate pathway, methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a methyl donor for remethylation of homocysteine to methionine, the precursor of S-adenosylmethionine. Folic Acid 11-17 methylenetetrahydrofolate reductase Homo sapiens 27-62 15548731-2 2005 Within the folate pathway, methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a methyl donor for remethylation of homocysteine to methionine, the precursor of S-adenosylmethionine. Folic Acid 11-17 methylenetetrahydrofolate reductase Homo sapiens 64-69 15777680-6 2005 We have, therefore, reviewed baseline food record data from our original study to determine if BMD and fracture associations with the MTHFR genotype depended on the intake of folate, riboflavin, or other members of the vitamin B complex, associated with homocysteine metabolism. Folic Acid 175-181 methylenetetrahydrofolate reductase Homo sapiens 134-139 15777680-13 2005 In conclusion, we confirm reports that BMD in the MTHFR TT genotype is only significantly reduced in the lowest quartile of riboflavin, B12, B6, and folate intake, at least at the time of menopause. Folic Acid 149-155 methylenetetrahydrofolate reductase Homo sapiens 50-55 16335688-6 2005 Several experimental study have shown that hypothyroidism affects folate metabolism and the enzymes involved in the remetylation pathway of homocysteine (particularly 5,10-methylenotetrahydrofolate reductase - MTHFR). Folic Acid 66-72 methylenetetrahydrofolate reductase Homo sapiens 210-215 15514969-2 2005 We conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [MTHFR] and methionine synthase [MS]) and cervical intraepithelial neoplasia (CIN) 2 or 3 in a population exposed to folic acid by the food fortification program in the United States. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 96-131 15514969-2 2005 We conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [MTHFR] and methionine synthase [MS]) and cervical intraepithelial neoplasia (CIN) 2 or 3 in a population exposed to folic acid by the food fortification program in the United States. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 133-138 15735067-8 2005 An interaction between the MTHFR genotype and plasma folate on tHcy was detected (P = 0.047). Folic Acid 53-59 methylenetetrahydrofolate reductase Homo sapiens 27-32 15735067-11 2005 The results also show that, similar to adults, plasma folate concentration is important in determining the contribution of the MTHFR C677T mutation to tHcy concentrations in children. Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 127-132 15916056-4 2005 When the data were grouped according to homocysteine concentration and MTHFR gene polymorphism, there were significantly higher homocysteine concentrations in the overweight/obese subjects than the control subjects in wild type gene polymorphism (CC) in the hyperhomocysteine group (homocysteine >10.0 mmol/l) (p < 0.05), but in genotype polymorphism (CC, CT, TT) there were lower folic acid and vitamin B12 concentrations in the overweight/obese subjects than in the control subjects. Folic Acid 387-397 methylenetetrahydrofolate reductase Homo sapiens 71-76 15719048-11 2005 Homozygous mutation at MTHFR and MTHFD loci made serum folic acid and Vit.B(12) levels slightly decreased and serum Hcy level increased. Folic Acid 55-65 methylenetetrahydrofolate reductase Homo sapiens 23-28 15734217-6 2005 Folate imbalance may result from alterations in folate cellular uptake by the reduced folate carrier (RFC) and/or the folate receptor (FR) and polymorphisms in enzymes important in folate retention such as folylpolyglutamate synthetase and in folate modification such as methylene tetrahydrofolate reductase (MTHFR). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 271-307 15734217-6 2005 Folate imbalance may result from alterations in folate cellular uptake by the reduced folate carrier (RFC) and/or the folate receptor (FR) and polymorphisms in enzymes important in folate retention such as folylpolyglutamate synthetase and in folate modification such as methylene tetrahydrofolate reductase (MTHFR). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 309-314 16045580-1 2005 SUMMARY: Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) are key enzymes in folate metabolism, which is essential for normal DNA methylation and synthesis. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 15895286-1 2005 This study aimed at assessing the effect of folic acid supplementation quantitatively in each MTHFR C677T genotype and considered the efficiency of tailor-made prevention of atherosclerosis. Folic Acid 44-54 methylenetetrahydrofolate reductase Homo sapiens 94-99 15585767-6 2004 Genotyping for the common methylenetetrahydrofolate reductase (MTHFR) 677C-->T, MTHFR 1298A-->C, cystathionine beta-synthase 844Ins68, methionine synthase 2756A-->C, methionine synthase reductase 66A-->G, and reduced folate carrier 80G-->A polymorphisms was carried out. Folic Acid 45-51 methylenetetrahydrofolate reductase Homo sapiens 63-68 15582924-2 2004 A thermolabile variant (677C>T) of the enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with low serum folate. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 91-96 15546509-1 2004 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15609483-4 2004 Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption. Folic Acid 206-212 methylenetetrahydrofolate reductase Homo sapiens 224-229 15609483-4 2004 Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption. Folic Acid 276-286 methylenetetrahydrofolate reductase Homo sapiens 187-222 15609483-4 2004 Among the polymorphic genes and environmental interactions discussed with respect to prenatal development are those for P-glycoprotein (multidrug resistance protein) and the avermectins; methylenetetrahydrofolate reductase (MTHFR), an enzyme in folate metabolism, and dietary folic acid; transforming growth factor alpha (TGFalpha) and cigarette smoke; and alcohol dehydrogenase (ADH) and cytochrome P-450 (CYP) 2E1 in association with alcohol consumption. Folic Acid 276-286 methylenetetrahydrofolate reductase Homo sapiens 224-229 15385937-1 2004 Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15548759-15 2004 Thus, folate deficiency may amplify the effect of other risk factors such as elevated homocysteine levels or variant MTHFR genotype, as well as influencing the ability of antioxidant supplementation to protect against genetic damage. Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 117-122 15380460-4 2004 Although ethnicity was not a statistically significant modifier, among carriers of the MTHFR 677T/T genotype with serum folate < or =14 nmol/L compared to >14 nmol/L, plasma homocysteine was significantly higher among South Asians (50.9% increase, P < 0.001) and Europeans (52.4% increase, P < 0.001) but not Chinese (11.0% increase, P > 0.05). Folic Acid 120-126 methylenetetrahydrofolate reductase Homo sapiens 87-92 15380460-7 2004 CONCLUSION: The combination of lower serum folate and the MTHFR 677T/T genotype is associated with increased plasma homocysteine among South Asians and Europeans, but the association is not evident among Chinese possibly because their serum folate may not have been low enough to compromise MTHFR activity. Folic Acid 43-49 methylenetetrahydrofolate reductase Homo sapiens 291-296 15380460-7 2004 CONCLUSION: The combination of lower serum folate and the MTHFR 677T/T genotype is associated with increased plasma homocysteine among South Asians and Europeans, but the association is not evident among Chinese possibly because their serum folate may not have been low enough to compromise MTHFR activity. Folic Acid 241-247 methylenetetrahydrofolate reductase Homo sapiens 58-63 15449187-2 2004 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15117811-12 2004 Our results strongly suggest that polymorphisms of the MTHFR and MS genes act together with low folate intake and smoking to increase bladder cancer risk. Folic Acid 96-102 methylenetetrahydrofolate reductase Homo sapiens 55-60 15342443-2 2004 We have investigated the relationships between two variants of the MTHFR gene (C677T and A1298C) and blood folate, homocysteine, and genomic stability (strand breakage, misincorporated uracil, and global cytosine methylation in lymphocytes) in a study of 199 subjects. Folic Acid 107-113 methylenetetrahydrofolate reductase Homo sapiens 67-72 15350988-9 2004 The response to folate repletion suggests that following folate depletion women with the MTHFR 677 TT genotype have a greater increase in DNA methylation with folate repletion than women with the CC genotype. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 89-94 15350988-9 2004 The response to folate repletion suggests that following folate depletion women with the MTHFR 677 TT genotype have a greater increase in DNA methylation with folate repletion than women with the CC genotype. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 89-94 15350988-9 2004 The response to folate repletion suggests that following folate depletion women with the MTHFR 677 TT genotype have a greater increase in DNA methylation with folate repletion than women with the CC genotype. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 89-94 15033905-1 2004 Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, plays a major role in the provision of methyl groups for DNA methylation and in the production of dTMP for DNA synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15216546-9 2004 The folate levels demonstrated a statistically significant decrease (P = 0.0477) from the C677T mutation in the MTHFR gene (TT genotype) when compared to the other groups. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 112-117 15103709-3 2004 In this study, we examined the two polymorphisms in genes encoding the folate metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR), namely, 677C > T and 1298A > C. The prevalence of these variant genotypes in mothers of DS children (case mothers) (n = 152) was compared with controls (n = 91). Folic Acid 71-77 methylenetetrahydrofolate reductase Homo sapiens 98-133 15103709-3 2004 In this study, we examined the two polymorphisms in genes encoding the folate metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR), namely, 677C > T and 1298A > C. The prevalence of these variant genotypes in mothers of DS children (case mothers) (n = 152) was compared with controls (n = 91). Folic Acid 71-77 methylenetetrahydrofolate reductase Homo sapiens 135-140 17301261-15 2007 Our findings suggest that folate intake may decrease the risk of endometrial cancer and modify the effect of MTHFR polymorphisms on risk. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 109-114 17240315-5 2007 Polymorphisms in methlyene tetrahydrofolate reductase (MTHFR) (involved in folate metabolism), apolipoprotein E (Apo E) and ApoA1 (in cardiovascular disease), and leptin/leptin receptor (obesity) genes are some good examples for understanding basic nutrigenetics. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 55-60 17438654-3 2007 Folate deficiency is associated with cancer risk that may be modulated by a genetic variation in the MTHFR gene in folate metabolism. Folic Acid 115-121 methylenetetrahydrofolate reductase Homo sapiens 101-106 16134079-2 2007 MTHFR is a key enzyme that regulates folate metabolism which has an important role in DNA synthesis, DNA repair and methylation. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 0-5 17684410-3 2007 We found that functional polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS), two key enzymes involved in folate and methyl group metabolism, were significantly associated with increased risk of esophageal squamous cell carcinoma, gastric cardia carcinoma, and pancreatic carcinoma. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 79-84 18333369-7 2007 Although methylenetetrahydrofolate reductase (MTHFR) C677T genotype and deficits of folic acid, vitamin B12 lead to hyperhomocysteinemia, in cases with a thrombotic event the correlations between homocysteine level and folic acid as well as between homocysteinemia and vitamin B12 were found to be weak and no significant correlation between homocysteinemia and MTHFR was identified. Folic Acid 219-229 methylenetetrahydrofolate reductase Homo sapiens 9-44 18333369-7 2007 Although methylenetetrahydrofolate reductase (MTHFR) C677T genotype and deficits of folic acid, vitamin B12 lead to hyperhomocysteinemia, in cases with a thrombotic event the correlations between homocysteine level and folic acid as well as between homocysteinemia and vitamin B12 were found to be weak and no significant correlation between homocysteinemia and MTHFR was identified. Folic Acid 219-229 methylenetetrahydrofolate reductase Homo sapiens 46-51 16917939-10 2006 Differences in allele frequency and/or significant gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G > A), transcobalamin II (TCN2 776G > C), catechol-O-methyltransferase (COMT 472G > A), methylenetetrahydrofolate reductase (MTHFR 677C > T and 1298A > C), and glutathione-S-transferase (GST M1). Folic Acid 125-131 methylenetetrahydrofolate reductase Homo sapiens 245-280 16917939-10 2006 Differences in allele frequency and/or significant gene-gene interactions were found for relevant genes encoding the reduced folate carrier (RFC 80G > A), transcobalamin II (TCN2 776G > C), catechol-O-methyltransferase (COMT 472G > A), methylenetetrahydrofolate reductase (MTHFR 677C > T and 1298A > C), and glutathione-S-transferase (GST M1). Folic Acid 125-131 methylenetetrahydrofolate reductase Homo sapiens 282-287 17243563-8 2006 Total cholesterol, triglycerides, vitamin B12 and folate were statistically different in "all MTHFR genotypes" (p<0.001, p<0.01, p=0.044 and p=0.036, respectively), and in TC/TT (p<0.001, p=0.003, p=0.030 and p=0.032, respectively) groups. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 94-99 17243563-14 2006 In the group of patients with TC/TT MTHFR genotype, lower vitamin B12 and higher folate values were recorded. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 36-41 17105984-3 2006 We conducted a meta-analysis to summarize the available evidence from observational studies on this issue and a meta-analysis of the association between a common polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, a key enzyme in folate metabolism, and breast cancer risk. Folic Acid 206-212 methylenetetrahydrofolate reductase Homo sapiens 224-229 16524711-0 2006 Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 111-116 16524711-0 2006 Additional food folate derived exclusively from natural sources improves folate status in young women with the MTHFR 677 CC or TT genotype. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 111-116 17071478-1 2006 Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the metabolism of folate. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 16920564-1 2006 Methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) play key roles in intracellular folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 16950805-10 2006 Folic acid concentration significantly affected radiation-induced micronuclei (P < 0.001): the increased incidence of radiation-induced micronuclei with low folic acid was mainly accounted for by carriers of the variant MTHFR allele (both homozygotes and heterozygotes), but the overall effect of genotype did not attain statistical significance. Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 223-228 16950805-10 2006 Folic acid concentration significantly affected radiation-induced micronuclei (P < 0.001): the increased incidence of radiation-induced micronuclei with low folic acid was mainly accounted for by carriers of the variant MTHFR allele (both homozygotes and heterozygotes), but the overall effect of genotype did not attain statistical significance. Folic Acid 160-170 methylenetetrahydrofolate reductase Homo sapiens 223-228 16950805-12 2006 The effect of folic acid level on this end-point was modulated by the MTHFR genotype (P for interaction = 0.02), with TT cells grown at low folic acid concentration apparently resistant to the induction of radiation-induced bridges. Folic Acid 14-24 methylenetetrahydrofolate reductase Homo sapiens 70-75 16936384-5 2006 STATISTICAL ANALYSIS: MTHFR gene polymorphism was correlated with serum folic acid, Vitamin B12 and Hcy levels; family history of stroke in first-degree relatives; and dietary habits; employing Chi-square test. Folic Acid 72-82 methylenetetrahydrofolate reductase Homo sapiens 22-27 16936384-12 2006 In 3 patients with MTHFR TT alleles, Hcy was elevated in all 3, low folic acid in 2 and family history of stroke in 1 patient. Folic Acid 68-78 methylenetetrahydrofolate reductase Homo sapiens 19-24 16621645-0 2006 The MTHFR 1298CC and 677TT genotypes have opposite associations with red cell folate levels. Folic Acid 78-84 methylenetetrahydrofolate reductase Homo sapiens 4-9 16706930-1 2006 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme involved in folate metabolism, DNA methylation and synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 16613994-4 2006 METHODS: Polymorphisms of factor V 1691G-->A, methylenetetrahydrofolate reductase (MTHFR) 677C --> T and 1298A --> C and plasma levels of total homocysteine, folate and vitamin B(12) were determined in blood samples collected in 1992-1993 from 5874 women aged 40-42 years, and linked with 14 474 pregnancies in the same women, recorded in the Medical Birth Registry of Norway, 1967-1996. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 86-91 16365753-2 2006 The common germ-line mutation C677T in the MTHFR gene significantly diminishes specific activity of the enzyme, which is responsible for the circulating form of folate. Folic Acid 161-167 methylenetetrahydrofolate reductase Homo sapiens 43-48 16365753-7 2006 CONCLUSIONS: The obtained results suggest that the MTHFR mutation is a minor contributing factor in oncogenesis in the oral region, in conjunction with low dietary uptake of folate. Folic Acid 174-180 methylenetetrahydrofolate reductase Homo sapiens 51-56 16402130-3 2006 A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating folate and homocysteine levels and offers insights into whether the association between low folate and depression is causal. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 33-38 16402130-3 2006 A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating folate and homocysteine levels and offers insights into whether the association between low folate and depression is causal. Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 92-97 16402130-3 2006 A common polymorphism (C677T) in MTHFR is associated with methyltetrahydrofolate reductase (MTHFR) activity and circulating folate and homocysteine levels and offers insights into whether the association between low folate and depression is causal. Folic Acid 124-130 methylenetetrahydrofolate reductase Homo sapiens 33-38 16538173-1 2006 5,10-Methylenetetrahydrofolate reductase (MTHFR) is an important enzyme in the folate metabolic pathway. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 16522920-11 2006 CONCLUSION: Our data agree with the hypothesis of a gene-nutrient interaction between MTHFR 677C-->T polymorphism and folate status that may confer a selective advantage of TT-homozygous genotype when dietary intake of folate is adequate, at least in the areas studied. Folic Acid 121-127 methylenetetrahydrofolate reductase Homo sapiens 86-91 16522920-11 2006 CONCLUSION: Our data agree with the hypothesis of a gene-nutrient interaction between MTHFR 677C-->T polymorphism and folate status that may confer a selective advantage of TT-homozygous genotype when dietary intake of folate is adequate, at least in the areas studied. Folic Acid 222-228 methylenetetrahydrofolate reductase Homo sapiens 86-91 16614955-1 2006 Inflammatory bowel disease (IBD) has been related to mutations of methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in the metabolism of folate and methionine, both of which are important factors in DNA methylation and synthesis. Folic Acid 85-91 methylenetetrahydrofolate reductase Homo sapiens 103-108 17163161-3 2006 In esophageal carcinomas, a higher gene expression of methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in folate metabolism, was more frequently found in responding patients. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 91-96 16489479-3 2006 Two common polymorphisms (SNPs), C677T and A1298C, in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene involved in folate metabolism, are known to lower the activity of this enzyme. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 100-105 15935452-6 2006 We then defined the genotype-specific threshold values of folate and vitamin B12 required to keep homocysteine levels in a normal range for individuals of each MTHFR C677T genotype. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 160-165 15935452-11 2006 CONCLUSION: We were able to define a gene-nutrient interaction that shows a higher risk for CAD based on specific threshold folate levels required by different MTHFR C677T genotypes in a Korean population. Folic Acid 124-130 methylenetetrahydrofolate reductase Homo sapiens 160-165 16372906-5 2005 5,10-MTHFR is a key enzyme in the folate metabolism, diverting metabolites toward methylation reactions or nucleotide synthesis. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 5-10 16317155-4 2005 The role of folate in these processes may be modulated by genotype for the common C677T thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), homozygosity for which is associated with lower enzyme activity, lower plasma and red blood cell folate, and elevated plasma homocysteine. Folic Acid 12-18 methylenetetrahydrofolate reductase Homo sapiens 112-148 16317155-4 2005 The role of folate in these processes may be modulated by genotype for the common C677T thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), homozygosity for which is associated with lower enzyme activity, lower plasma and red blood cell folate, and elevated plasma homocysteine. Folic Acid 12-18 methylenetetrahydrofolate reductase Homo sapiens 150-155 16317155-6 2005 The MTHFR C677T polymorphism appears to interact with folate and riboflavin in modulating cancer risk in a manner that varies according to cancer site. Folic Acid 54-60 methylenetetrahydrofolate reductase Homo sapiens 4-9 16275406-3 2005 Methylenetetrahydrofolate reductase (MTHFR) gene mutations at nucleotides 677 and 1298 cause reduced MTHFR enzyme activity, which leads to increased homocysteine and reduced serum folate levels that are known to be involved in vascular impairment. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 16275406-3 2005 Methylenetetrahydrofolate reductase (MTHFR) gene mutations at nucleotides 677 and 1298 cause reduced MTHFR enzyme activity, which leads to increased homocysteine and reduced serum folate levels that are known to be involved in vascular impairment. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 101-106 16259797-2 2005 MTHFR C(677)T increases tHcy in association with low folate. Folic Acid 53-59 methylenetetrahydrofolate reductase Homo sapiens 0-5 16259797-8 2005 RESULTS: MTHFR TT predisposed to hyperhomocysteinaemia; this was increased in the presence of low folate (P<0.05) and vitamin B(12) (P<0.01). Folic Acid 98-104 methylenetetrahydrofolate reductase Homo sapiens 9-14 16145688-1 2005 The enzyme, 5,10-methylenetetrahydrofolate reductase (MTHFR) plays a key role in cellular folate metabolism. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 16272757-1 2005 The genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been associated with increased toxicity of methotrexate (MTX), a folic acid antagonist that is widely used to treat cancer and immunosuppressive disorders such as rheumatoid arthritis. Folic Acid 143-153 methylenetetrahydrofolate reductase Homo sapiens 29-64 16272757-1 2005 The genetic polymorphisms of methylenetetrahydrofolate reductase (MTHFR) have been associated with increased toxicity of methotrexate (MTX), a folic acid antagonist that is widely used to treat cancer and immunosuppressive disorders such as rheumatoid arthritis. Folic Acid 143-153 methylenetetrahydrofolate reductase Homo sapiens 66-71 16177213-1 2005 5,10-Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme in folate-mediated 1-carbon metabolism. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 43-48 16363341-2 2005 Among the single nucleotide polymorphisms (SNPs) influencing the folate metabolism, the methylenetetrahydrofolate reductase (MTHFR) gene has been the one most exclusively studied. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 88-123 16363341-2 2005 Among the single nucleotide polymorphisms (SNPs) influencing the folate metabolism, the methylenetetrahydrofolate reductase (MTHFR) gene has been the one most exclusively studied. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 125-130 16234003-9 2005 Among cancers with loss of an MTHFR allele, cancers with 677T MTHFR alleles had more deletions at folate-sensitive fragile sites (36.9%) and at tumor suppressor gene loci (68.5%) than 677C cancers (28.7% and 47.8%, P = .079 and .014, respectively). Folic Acid 98-104 methylenetetrahydrofolate reductase Homo sapiens 30-35 16234003-9 2005 Among cancers with loss of an MTHFR allele, cancers with 677T MTHFR alleles had more deletions at folate-sensitive fragile sites (36.9%) and at tumor suppressor gene loci (68.5%) than 677C cancers (28.7% and 47.8%, P = .079 and .014, respectively). Folic Acid 98-104 methylenetetrahydrofolate reductase Homo sapiens 62-67 16096524-1 2005 Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in folate metabolism and in DNA methylation and synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 16030402-3 2005 Methylenetetrahydrofolate reductase (MTHFR) plays a central role in converting folate to methyl donor for DNA methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15870856-8 2005 Functional polymorphisms in folate-metabolizing genes, especially the methylenetetrahydrofolate reductase (MTHFR) are capable of modifying the risk of colorectal cancer. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 70-105 15870856-8 2005 Functional polymorphisms in folate-metabolizing genes, especially the methylenetetrahydrofolate reductase (MTHFR) are capable of modifying the risk of colorectal cancer. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 107-112 15870856-9 2005 Observational studies show that individuals with the homozygote genotype for the MTHFR (677C-->T) polymorphism are at higher risk when folic acid supply is low. Folic Acid 138-148 methylenetetrahydrofolate reductase Homo sapiens 81-86 15949101-2 2005 Folate pathways may be modified by polymorphisms in relevant genes, such as that for methylenetetrahydrofolate reductase (MTHFR), or by alcohol consumption. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 85-120 15949101-2 2005 Folate pathways may be modified by polymorphisms in relevant genes, such as that for methylenetetrahydrofolate reductase (MTHFR), or by alcohol consumption. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 122-127 15840047-0 2005 Associations between MTHFR 1793G>A and plasma total homocysteine, folate, and vitamin B in kidney transplant recipients. Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 21-26 15824167-1 2005 Methylenetetrahydrofolate reductase (MTHFR) balances the pool of folate coenzymes in one-carbon metabolism for DNA synthesis and methylation, both implicated in carcinogenesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15824167-3 2005 We aimed to analyze lymphocyte DNA from 198 subjects to evaluate the MTHFR 1298A>C polymorphism and folate status affecting genomic DNA methylation as a possible mechanism underlying the relationship between MTHFR polymorphisms and cancer susceptibility. Folic Acid 103-109 methylenetetrahydrofolate reductase Homo sapiens 211-216 15781665-3 2005 Methylenetetrahydrofolate reductase (MTHFR) is central to folate metabolism and has two common functional polymorphisms (C677T and A1298G). Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15756031-2 2005 Methylenetetrahydrofolate reductase (MTHFR) generates the folate derivative for homocysteine remethylation to methionine. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15635481-1 2005 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme regulating the metabolism of folate and methionine. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15952646-1 2005 OBJECTIVE: Methylene tetrahydrofolate reductase (MTHFR) is the key enzyme in folate metabolism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 15720206-7 2005 Remarkably, a gene-nutrient interaction between folate status and a polymorphism in methylenetetrahydrofolate reductase gene has been reported to modulate genomic DNA methylation. Folic Acid 48-54 methylenetetrahydrofolate reductase Homo sapiens 84-119 15643524-2 2005 Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and influences DNA methylation and nucleotide synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15643524-3 2005 MTHFR is highly polymorphic and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level. Folic Acid 113-119 methylenetetrahydrofolate reductase Homo sapiens 0-5 15829374-1 2005 The aim of this study was to investigate the association of environmental factors (dietary folate, methionine and drinking status) and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene, as well as the combination of these factors, with the risk of colon cancer and rectal cancer. Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 156-191 15829374-1 2005 The aim of this study was to investigate the association of environmental factors (dietary folate, methionine and drinking status) and polymorphisms in the methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) gene, as well as the combination of these factors, with the risk of colon cancer and rectal cancer. Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 193-198 15829374-8 2005 Adequate intake of folate was a protective factor from colon cancer (OR=0.32, 95% CI: 0.12-0.88) and MTHFR C677T polymorphism showed a statistically significant effect (OR=0.25, 95% CI: 0.06-0.93), reducing the risk of colon cancer in groups that have an intake of folate exceeding 115.64ng per 1000kcal per day. Folic Acid 265-271 methylenetetrahydrofolate reductase Homo sapiens 101-106 15829374-11 2005 There is a significant interaction between MTHFR C677T polymorphism and folate intake in reducing the risk of colon cancer. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 43-48 16433478-6 2005 Patients homozygous and, to a lesser extent heterozygous, to the C677T thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) presented a reduced catalytic activity and required a higher folic acid dose. Folic Acid 200-210 methylenetetrahydrofolate reductase Homo sapiens 95-130 16433478-6 2005 Patients homozygous and, to a lesser extent heterozygous, to the C677T thermolabile variant of methylenetetrahydrofolate reductase (MTHFR) presented a reduced catalytic activity and required a higher folic acid dose. Folic Acid 200-210 methylenetetrahydrofolate reductase Homo sapiens 132-137 15829163-4 2005 Homozygous MTHFR gene mutation was associated with reduced plasma folate levels, but not with increased plasma HCY levels. Folic Acid 66-72 methylenetetrahydrofolate reductase Homo sapiens 11-16 15829163-5 2005 Among the subjects with homozygous MTHFR gene mutation, plasma folate levels in CH was significantly lower than those in CI and controls. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 35-40 15829163-6 2005 MTHFR gene mutation in CH was found to be as common as that in CI and was associated with reduced plasma folate levels in the both. Folic Acid 105-111 methylenetetrahydrofolate reductase Homo sapiens 0-5 15829163-7 2005 In homozygous MTHFR gene mutation, the plasma folate level was profoundly reduced in CH as compared with CI and controls, suggesting that subjects with low plasma folate levels have a predisposition to intracerebral bleeding. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 14-19 15829163-7 2005 In homozygous MTHFR gene mutation, the plasma folate level was profoundly reduced in CH as compared with CI and controls, suggesting that subjects with low plasma folate levels have a predisposition to intracerebral bleeding. Folic Acid 163-169 methylenetetrahydrofolate reductase Homo sapiens 14-19 15588157-2 2005 We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 113-153 15588157-2 2005 We explored whether blood folate concentrations in healthy Czech population are associated with polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), folate hydrolase 1 (FOLH1), reduced folate carrier (RFC), and folate receptor (FOLR1) genes. Folic Acid 26-32 methylenetetrahydrofolate reductase Homo sapiens 155-160 15588157-6 2005 Only the MTHFR 677C>T variant was significantly associated with plasma folate concentrations (median 14.7, 14.0 and 12.2 nmol/l for the CC, CT and TT genotypes, respectively). Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 9-14 15588157-7 2005 Our study showed that among the five studied allelic variants, only the 677C>T polymorphism in the MTHFR gene is a significant genetic determinant of plasma folate concentrations in Czech population. Folic Acid 160-166 methylenetetrahydrofolate reductase Homo sapiens 102-107 15598763-1 2004 Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in the metabolism of folate, a nutrient which has recently been found to be inversely related to breast cancer in women who drink alcohol. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15598763-2 2004 Two common variants in the MTHFR gene (C677T and A1298C) have been associated with a reduced activity of this enzyme, thereby increasing the availability of folate for thymidylate and purine synthesis. Folic Acid 157-163 methylenetetrahydrofolate reductase Homo sapiens 27-32 15598763-12 2004 This is consistent with the role of MTHFR in facilitating the flow of folate for thymidylate and purine synthesis and with the increased nucleic acid need resulting from the hyperproliferative effect of HRT on mammary epithelial cells. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 36-41 15569990-1 2004 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) directs intracellular folate toward homocysteine metabolism and away from nucleotide synthesis. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 15569990-12 2004 CONCLUSIONS: These findings suggest that individuals with the 677CC/1298AA genotype are at higher risk of relapse after hematopoietic cell transplantation and that the balance of intracellular folate metabolites available for nucleotide synthesis (regulated by the relative activity of the MTHFR enzyme) may affect the progression from bcr-abl positivity to clinical relapse. Folic Acid 193-199 methylenetetrahydrofolate reductase Homo sapiens 290-295 15546509-9 2004 The findings add to evidence that individuals with the MTHFR 677TT genotype have a decreased risk of colorectal cancer in the absence of folate depletion, suggesting a protective role of folate by ensuring a sufficient thymidylate pool for DNA synthesis. Folic Acid 187-193 methylenetetrahydrofolate reductase Homo sapiens 55-60 15492840-2 2004 Genetic polymorphisms that decrease MTHFR activity result in an altered cancer risk depending on folic acid intake. Folic Acid 97-107 methylenetetrahydrofolate reductase Homo sapiens 36-41 15688606-5 2004 Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in the folate cycle, presenting two common polymorphisms (677C>T and 1298 A>C) which have impact on toxicity and efficacy of methotrexate and 5-fluorouracil. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15561486-0 2004 Methylenetetrahydrofolate reductase polymorphism determines the plasma homocysteine-lowering effect of large-dose folic acid supplementation in patients with cardiovascular disease. Folic Acid 114-124 methylenetetrahydrofolate reductase Homo sapiens 0-35 15561486-2 2004 The present study investigated the total homocysteine-lowering effect of folic acid in response to the MTHFR genotype in patients who have cardiovascular disease. Folic Acid 73-83 methylenetetrahydrofolate reductase Homo sapiens 103-108 15561486-8 2004 CONCLUSIONS: The MTHFR polymorphism may be involved in the total homocysteine-lowering effect of folic acid in patients who have cardiovascular disease. Folic Acid 97-107 methylenetetrahydrofolate reductase Homo sapiens 17-22 15198953-8 2004 The associations of DLCL and FL with TYMS 1494del6 and MTHFR 677TT genotypes, respectively, suggest that folate metabolism may play an important role in the pathogenesis of specific subtypes of NHL. Folic Acid 105-111 methylenetetrahydrofolate reductase Homo sapiens 55-60 15378677-5 2004 A recently discovered genetic variant (5,10 MTHFR) leading to altered folic acid metabolism may explain why some individuals are vulnerable to the effects of folic acid deficiency, despite adequate intake. Folic Acid 70-80 methylenetetrahydrofolate reductase Homo sapiens 44-49 15378677-5 2004 A recently discovered genetic variant (5,10 MTHFR) leading to altered folic acid metabolism may explain why some individuals are vulnerable to the effects of folic acid deficiency, despite adequate intake. Folic Acid 158-168 methylenetetrahydrofolate reductase Homo sapiens 44-49 15510613-2 2004 Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism. Folic Acid 55-61 methylenetetrahydrofolate reductase Homo sapiens 73-78 15355664-8 2004 The MTHFR C667T polymorphism was associated with the concentration of plasma folic acid but not with the concentration of plasma homocysteine in both the case group and the control group. Folic Acid 77-87 methylenetetrahydrofolate reductase Homo sapiens 4-9 15355664-9 2004 The multiple correlation coefficient between the MTHFR C667T polymorphism and the concentration of plasma folic acid is 0.5856 (P < 0.01). Folic Acid 106-116 methylenetetrahydrofolate reductase Homo sapiens 49-54 15210385-1 2004 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is involved in the metabolism of folate and homocysteine; a polymorphism in the MTHFR gene (677C-->T) has been associated with adverse outcomes of pregnancy. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 15210385-1 2004 PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is involved in the metabolism of folate and homocysteine; a polymorphism in the MTHFR gene (677C-->T) has been associated with adverse outcomes of pregnancy. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 133-138 15136061-6 2004 Among smokers, the MTHFR 677TT genotype was significantly associated with high tHcy in heavy smokers (P = 0.003) but not light smokers (P = 0.09), in men (P = 0.003) but not women (P = 0.11), and in subjects from the lowest serum folate quartile (P = 0.49) but not from folate quartiles 2-4 (P = 0.49). Folic Acid 230-236 methylenetetrahydrofolate reductase Homo sapiens 19-24 15136061-6 2004 Among smokers, the MTHFR 677TT genotype was significantly associated with high tHcy in heavy smokers (P = 0.003) but not light smokers (P = 0.09), in men (P = 0.003) but not women (P = 0.11), and in subjects from the lowest serum folate quartile (P = 0.49) but not from folate quartiles 2-4 (P = 0.49). Folic Acid 270-276 methylenetetrahydrofolate reductase Homo sapiens 19-24 15136061-8 2004 We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low. Folic Acid 112-118 methylenetetrahydrofolate reductase Homo sapiens 40-45 15286469-4 2004 The multivariate-adjusted ORs comparing the highest to lowest tertile of total folate intake according to those with the MTHFR CC, CT, and TT genotypes, were, respectively, 0.65 (CI: 0.30-1.39), 0.57 (CI: 0.23-1.44), and 0.22 (CI: 0.02-3.19). Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 121-126 15217535-7 2004 Carriers of the MTHFR 677T allele could benefit from supplementation with folic acid and vitamin B12. Folic Acid 74-84 methylenetetrahydrofolate reductase Homo sapiens 16-21 15110890-0 2004 Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 109-144 15122759-4 2004 Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH). Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 99-134 15122759-4 2004 Ethanol feeding or folate deficiency, separately or in combination, decreased transcript levels of methylenetetrahydrofolate reductase (MTHFR), methionine adenosyltransferase (MAT1A), glycine-N-methyltransferase (GNMT) and S-adenosylhomocysteine hydrolase (SAHH). Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 136-141 15044114-5 2004 In the regression equation ( y= ax + b) of serum folate ( y nmol/L) plotted against mean folate intake ( x microg/day), the values of "a" were 0.032, 0.037, and 0.045 for individuals with CC, CT, and TT alleles, respectively, of MTHFR. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 229-234 20396547-7 2004 The protective effect of the homozygous variant TT form of the MTHFR genotype on the risk of colon cancer seems to be modified by the level of methyl diets, i.e., by folate, which has a protective effect, or conversely by alcohol. Folic Acid 166-172 methylenetetrahydrofolate reductase Homo sapiens 63-68 15059614-11 2004 Erythrocyte folate levels were depressed in the presence of the MTHFR 677C >T variant. Folic Acid 12-18 methylenetetrahydrofolate reductase Homo sapiens 64-69 14987511-9 2004 There was an association between age-MTHFR genotype and folic acid, vitamin B12, and red cell folate, but not with homocysteine concentrations. Folic Acid 56-66 methylenetetrahydrofolate reductase Homo sapiens 37-42 14987511-9 2004 There was an association between age-MTHFR genotype and folic acid, vitamin B12, and red cell folate, but not with homocysteine concentrations. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 37-42 15161007-1 2004 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in folate metabolism, which is an important pathway of the methyl donor for DNA methylation. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 15161007-3 2004 Impaired folate metabolism by these genetic variants of MTHFR could change the methylation pattern of DNA including promoter hypermethylation, which has been frequently observed in cancer. Folic Acid 9-15 methylenetetrahydrofolate reductase Homo sapiens 56-61 14769778-2 2004 Methylenetetrahydrofolate reductase (MTHFR) is a regulating enzyme in folate-dependant homocysteine remethylation, because it catalyses the reduction of 5,10 methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 15207432-3 2004 Both the MTHFR 677C-->T and the 1298A-->C polymorphisms are associated with mild hyperhomocysteinemia, particularly in conditions of low folate status. Folic Acid 143-149 methylenetetrahydrofolate reductase Homo sapiens 9-14 12958073-1 2004 The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 57-62 12958073-1 2004 The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance. Folic Acid 39-45 methylenetetrahydrofolate reductase Homo sapiens 97-102 12958073-1 2004 The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance. Folic Acid 71-77 methylenetetrahydrofolate reductase Homo sapiens 20-55 12958073-1 2004 The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance. Folic Acid 71-77 methylenetetrahydrofolate reductase Homo sapiens 57-62 12958073-1 2004 The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety of disorders whose development depends on folate/homocysteine imbalance. Folic Acid 71-77 methylenetetrahydrofolate reductase Homo sapiens 97-102 12958073-5 2004 Further stratification in patients born before and after January 1996 (approximate time of Health Canada recommendation for folic acid supplement in pregnancy) revealed that the protective effect of MTHFR variants is accentuated and present only in children born before 1996. Folic Acid 124-134 methylenetetrahydrofolate reductase Homo sapiens 199-204 14717963-7 2004 For all MTHFR genotypes combined, the OR for MI in the lowest quartile of folate (<5.4 nmol L-1) compared with the highest quartile (>10.4 nmol L-1) was 3.0 (95% CI 1.7, 5.1). Folic Acid 74-80 methylenetetrahydrofolate reductase Homo sapiens 8-13 15970629-1 2004 Hyperhomocysteinemia can result from decreased methylenetetrahydrofolate reductase (MTHFR) enzyme activity, owing to genetic polymorphisms andor inadequate folate intake. Folic Acid 66-72 methylenetetrahydrofolate reductase Homo sapiens 84-89 14652356-0 2003 Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C-->T polymorphism in young women. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 70-105 14652356-0 2003 Folate status response to controlled folate intake is affected by the methylenetetrahydrofolate reductase 677C-->T polymorphism in young women. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 70-105 14652356-1 2003 This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 91-96 14652356-1 2003 This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 54-89 14652356-1 2003 This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 91-96 14652356-1 2003 This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 54-89 14652356-1 2003 This study was designed to evaluate the effect of the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism on folate and homocysteine response in non-Hispanic women consuming a low folate diet followed by a diet providing the Recommended Dietary Allowance (RDA) for folate. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 91-96 14652356-8 2003 These data suggest that the MTHFR 677C-->T polymorphism negatively affects the folate and homocysteine response in women consuming low folate diets followed by repletion with the RDA. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 28-33 14652356-8 2003 These data suggest that the MTHFR 677C-->T polymorphism negatively affects the folate and homocysteine response in women consuming low folate diets followed by repletion with the RDA. Folic Acid 138-144 methylenetetrahydrofolate reductase Homo sapiens 28-33 14652356-9 2003 These results may be important when evaluating the impact of the MTHFR 677C-->T polymorphism in countries in which low folate diets are chronically consumed. Folic Acid 122-128 methylenetetrahydrofolate reductase Homo sapiens 65-70 14607573-0 2003 C677T methylenetetrahydrofolate reductase polymorphism interferes with the effects of folic acid and zinc sulfate on sperm concentration. Folic Acid 86-96 methylenetetrahydrofolate reductase Homo sapiens 6-41 14607573-1 2003 OBJECTIVE: To determine the frequency of C677T methylenetetrahydrofolate reductase (MTHFR) polymorphism in fertile and subfertile males, and the MTHFR-dependent response of sperm concentration after folic acid and/or zinc sulfate intervention. Folic Acid 199-209 methylenetetrahydrofolate reductase Homo sapiens 145-150 14607573-11 2003 In contrast to heterozygotes and homozygotes for C677T MTHFR polymorphism, sperm concentration in wild-types significantly improved after folic acid and zinc sulfate intervention. Folic Acid 138-148 methylenetetrahydrofolate reductase Homo sapiens 55-60 14572619-4 2003 In addition to the prevalence of the 677C-->T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, we compared plasma and red blood cell (RBC) folate, vitamin B6, vitamin B12, and homocysteine (Hcy) concentrations of 35 schizophrenic patients with those of 104 unrelated controls. Folic Acid 89-95 methylenetetrahydrofolate reductase Homo sapiens 107-112 13678724-2 2003 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme regulating the metabolism of folate and methionine, the important components of DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 12949355-0 2003 Combined marginal folate and riboflavin status affect homocysteine methylation in cultured immortalized lymphocytes from persons homozygous for the MTHFR C677T mutation. Folic Acid 18-24 methylenetetrahydrofolate reductase Homo sapiens 148-153 12684695-2 2003 Thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) are key enzymes in the folate metabolism and both have been shown to be polymorphic affecting the enzyme activity. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 67-72 12730409-0 2003 Methylenetetrahydrofolate reductase 677C-->T variant modulates folate status response to controlled folate intakes in young women. Folic Acid 66-72 methylenetetrahydrofolate reductase Homo sapiens 0-35 12672677-5 2003 Mothers carrying the MTHFR 677TT genotype and who either did not use folic acid supplements periconceptionally or had a low dietary folate intake, or both, had an increased risk of delivering a CL(P) child (odds ratio (OR) = 5.9, 95% confidence interval (CI): 1.1, 30.9; OR = 2.8, 95% CI: 0.7, 10.5; OR = 10.0, 95% CI: 1.3, 79.1, respectively). Folic Acid 132-138 methylenetetrahydrofolate reductase Homo sapiens 21-26 12672677-7 2003 Thus, the detrimental effect of low periconceptional folate intake on the risk of giving birth to a CL(P) child was more pronounced in mothers with the MTHFR 677TT or MTHFR 1298CC genotype. Folic Acid 53-59 methylenetetrahydrofolate reductase Homo sapiens 152-157 12672677-7 2003 Thus, the detrimental effect of low periconceptional folate intake on the risk of giving birth to a CL(P) child was more pronounced in mothers with the MTHFR 677TT or MTHFR 1298CC genotype. Folic Acid 53-59 methylenetetrahydrofolate reductase Homo sapiens 167-172 12966656-4 2003 Moreover there is a genetic factor with higher incidence of a TT homozygotic mutation of the MTHFR that increases homocysteine because of an altered folate metabolism. Folic Acid 149-155 methylenetetrahydrofolate reductase Homo sapiens 93-98 12642343-3 2003 Serum folate, red cell folate, vitamin B(12), and tHcy concentrations were significantly influenced by MTHFR 677C>T genotypes. Folic Acid 6-12 methylenetetrahydrofolate reductase Homo sapiens 103-108 12642343-3 2003 Serum folate, red cell folate, vitamin B(12), and tHcy concentrations were significantly influenced by MTHFR 677C>T genotypes. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 103-108 12642343-4 2003 A particularly strong interaction was observed between the MTHFR 677TT genotype and serum folate, which led to a high tHcy phenotype that was more pronounced in males. Folic Acid 90-96 methylenetetrahydrofolate reductase Homo sapiens 59-64 12651974-3 2003 A common 677C-->T mutation in the MTHFR gene results in decreased enzymic activity, and contributes to increased plasma tHcy, in association with low plasma folate. Folic Acid 160-166 methylenetetrahydrofolate reductase Homo sapiens 37-42 12649184-2 2003 A common Ala(222)/Val variant in the methylenetetrahydrofolate reductase (MTHFR) gene leads to a disturbed folate metabolism and is associated with decreased genomic DNA methylation. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 74-79 12553950-5 2003 Folate status assessment was determined by plasma tHcy, serum and erythrocyte folate and C677T for MTHFR in 342 healthy women. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 99-104 12522558-1 2003 Elevated levels of plasma homocysteine (Hcy), a risk factor for coronary artery disease (CAD), can result from genetic errors, e.g., the methylenetetrahydrofolate reductase (MTHFR) polymorphism, or nutritional deficiencies, e.g., in vitamin B12 and folate. Folic Acid 156-162 methylenetetrahydrofolate reductase Homo sapiens 174-179 12626825-4 2003 Based on evidence that abnormal folate and methyl metabolism can lead to DNA hypomethylation and abnormal chromosomal segregation, researchers have observed that mothers with mutation in MTHFR (C677T) and MTRR (A66G) gene have elevated levels of plasma homocysteine. Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 187-192 12589326-1 2003 OBJECTIVE: To determine the prevalence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms in women of different ethnic groups and to relate these common mutations to plasma homocysteine, red cell folate, and serum folate. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 79-84 12471611-1 2003 MTHFR is a critical enzyme that regulates the metabolism of folate and methionine, both of which are important factors in DNA methylation and synthesis. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 0-5 12784029-4 2003 OBJECTIVE: To analyse the correlation between the ApoE and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma homocysteine levels and vitamins (B(12) and folic acid) concentrations in serum from patients with AD and mild cognitive impairment (MCI) as compared with control group. Folic Acid 177-187 methylenetetrahydrofolate reductase Homo sapiens 96-101 12784029-9 2003 RESULTS: We found that plasma total homocysteine is increased in AD patients (p < 0.0001) and depended on the MTHFR T/T genotype in the presence of low folate levels (p < 0.05). Folic Acid 152-158 methylenetetrahydrofolate reductase Homo sapiens 110-115 14564626-7 2003 Methylene-tetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are the enzymes involved in folate metabolism and are thought to influence DNA methylation. Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 14564626-8 2003 MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level. Folic Acid 114-120 methylenetetrahydrofolate reductase Homo sapiens 0-5 12560871-1 2003 Common single nucleotide polymorphisms (SNPs; 677C>T and 1298A>C) in the methylenetetrahydrofolate reductase gene ( MTHFR) decrease the activity of the enzyme, leading to hyperhomocysteinemia, particularly in folate-deficient states. Folic Acid 98-104 methylenetetrahydrofolate reductase Homo sapiens 122-127 15068389-1 2003 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) plays a critical role in folate metabolism and displays common genetic polymorphisms affecting the enzyme activity. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 12453860-1 2002 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, a common mutation of the gene encoding the enzyme that catalyzes reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor in the metabolism of folate, determines a striking reduction in the enzyme activity in carriers of mutation at homozygous status. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 12384833-2 2002 A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C-->T) is a known risk factor for NTDs, but the prevalence of the risk genotype explains only a small portion of the protective effect of folic acid. Folic Acid 207-217 methylenetetrahydrofolate reductase Homo sapiens 18-53 12384833-2 2002 A variant form of methylenetetrahydrofolate reductase (MTHFR) (677C-->T) is a known risk factor for NTDs, but the prevalence of the risk genotype explains only a small portion of the protective effect of folic acid. Folic Acid 207-217 methylenetetrahydrofolate reductase Homo sapiens 55-60 12387655-2 2002 The MTHFR 677C-->T polymorphism is a genetic alteration in an enzyme involved in folate metabolism that causes elevated homocysteine concentrations, but its relevance to risk of CHD is uncertain. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 4-9 12387655-12 2002 CONCLUSIONS: Individuals with the MTHFR 677 TT genotype had a significantly higher risk of CHD, particularly in the setting of low folate status. Folic Acid 131-137 methylenetetrahydrofolate reductase Homo sapiens 34-39 12215845-4 2002 These associations were independent of the well-established methylenetetrahydrofolate reductase ( MTHFR) C677T genotype effects on plasma folate and homocysteine levels. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 98-103 12215845-5 2002 Our results suggest that TYMS and MTHFR compete for limiting supplies of folate required for the remethylation of homocysteine. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 34-39 12145019-1 2002 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR; EC 1.7.99.5) supplies the folate needed for the metabolism of homocysteine. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 12180000-14 2002 However, in folic acid resistant group, who were in 30% homozygotes for C667T of MTHFR (suggesting that homocysteine-methionine remethylation cycle is disturbed), instead of the administration of folic acid, methylene tetrahydrofolate supplementation might be considered. Folic Acid 12-22 methylenetetrahydrofolate reductase Homo sapiens 81-86 12097662-5 2002 The C677T and A1298C MTHFR polymorphisms were significant predictors (P < 0.05) of plasma homocysteine when regression analysis was used to model plasma homocysteine concentration as a function of genotype, supplement use, serum folate and plasma vitamin B-12 concentration. Folic Acid 232-238 methylenetetrahydrofolate reductase Homo sapiens 21-26 12042673-1 2002 A common polymorphism in a folate-metabolizing gene, methylenetetrahydrofolate reductase (MTHFR) 677C>T has been associated with reduced risk of colorectal cancer. Folic Acid 27-33 methylenetetrahydrofolate reductase Homo sapiens 53-88 12042673-1 2002 A common polymorphism in a folate-metabolizing gene, methylenetetrahydrofolate reductase (MTHFR) 677C>T has been associated with reduced risk of colorectal cancer. Folic Acid 27-33 methylenetetrahydrofolate reductase Homo sapiens 90-95 12042673-2 2002 In this study, we investigated whether a second common polymorphism of the gene, MTHFR 1298A>C, is an independent risk factor for colorectal cancer and if it is associated with plasma folate and total homocysteine (tHcy) levels. Folic Acid 187-193 methylenetetrahydrofolate reductase Homo sapiens 81-86 12133463-1 2002 OBJECTIVE: To explore the relationship between genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism that affects DNA methylation and synthesis, and the risk of adenocarcinoma of the gastric cardia (AGC). Folic Acid 91-97 methylenetetrahydrofolate reductase Homo sapiens 109-114 11979347-13 2002 These results indicate that MTHFR genotype influences the correlation of Hcy level with vitamin B12 and folate levels in HD patients. Folic Acid 104-110 methylenetetrahydrofolate reductase Homo sapiens 28-33 11979347-15 2002 The efficacy of vitamin B12 and folate supplementation on plasma Hcy levels may depend on MTHFR genotype. Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 90-95 12042168-1 2002 Relationship with plasmatic folic acid levels and 677C T polymorphism of 5,10-methylenetetrahydrofolate reductase]. Folic Acid 28-38 methylenetetrahydrofolate reductase Homo sapiens 73-113 12186157-3 2002 Our study was aimed at finding the relationship between HCA, folate, vitamins B12 levels, and mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 111-151 12186157-3 2002 Our study was aimed at finding the relationship between HCA, folate, vitamins B12 levels, and mutations in the 5,10-methylenetetrahydrofolate reductase (MTHFR) and cystathionine beta-synthase (CBS) genes. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 153-158 11929966-9 2002 These results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status. Folic Acid 119-125 methylenetetrahydrofolate reductase Homo sapiens 32-37 11880124-1 2002 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) deficiency leads to impairment in folate metabolism and is implicated as a risk factor for neural tube defects (NTDs). Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 11781870-2 2002 When folic acid intake is sufficient, homozygotes for MTHFR 677T appear to be protected against colon cancer and acute lymphatic leukemia, and fetuses bearing this genotype have an augmented survival. Folic Acid 5-15 methylenetetrahydrofolate reductase Homo sapiens 54-59 11872199-10 2002 CONCLUSION(S): The MTHFR polymorphism was associated with a higher Hcy concentration, and this association was related to the serum folate level. Folic Acid 132-138 methylenetetrahydrofolate reductase Homo sapiens 19-24 11865092-16 2002 (ii) After folate therapy, tHcy levels decreased significantly in all patients and were identical between the three C677T MTHFR genotype subgroups. Folic Acid 11-17 methylenetetrahydrofolate reductase Homo sapiens 122-127 11600611-2 2001 Functional polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene result in intracellular redistribution of folate derivatives, which may affect raltitrexed-associated cytotoxicity. Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 69-74 11686575-3 2001 Folate is the strongest nutritional and pharmacological determinant of plasma homocysteine concentrations, which also interact with the genetic variation in methylenetetrahydrofolate reductase (MTHFR). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 157-192 11686575-3 2001 Folate is the strongest nutritional and pharmacological determinant of plasma homocysteine concentrations, which also interact with the genetic variation in methylenetetrahydrofolate reductase (MTHFR). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 194-199 11481906-2 2001 Hyperhomocysteinemia may be induced by failure or decreased enzyme activity of the cystathionine-beta-synthase and methylenetetrahydrofolate reductase due to genetic mutation or deficiency of folic acid, vitamin B12 and vitamin B6. Folic Acid 192-202 methylenetetrahydrofolate reductase Homo sapiens 115-150 11520404-5 2001 The second hypothesised pathway is a gene-environment interaction based on a highly prevalent mutation in the gene for methylenetetrahydrofolate reductase (MTHFR), combined with low folate intake from the diet and from prenatal vitamin supplements, consequent hyperhomocysteinemia, and decidual vasculopathy. Folic Acid 138-144 methylenetetrahydrofolate reductase Homo sapiens 156-161 15040829-0 2004 Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 81-86 15040829-2 2004 Our findings support the hypothesis that the association between an MTHFR polymorphism and bone phenotypes depends on folate status. Folic Acid 118-124 methylenetetrahydrofolate reductase Homo sapiens 68-73 15040829-4 2004 Individuals homozygous (TT) for the MTHFR C677T polymorphism who have low plasma folate concentrations exhibit elevated plasma homocysteine (tHcy) concentrations that may compromise bone quality. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 36-41 15040829-15 2004 CONCLUSIONS: Our findings support the hypothesis that the association between the C677T MTHFR polymorphism and bone phenotypes depends on folate status. Folic Acid 138-144 methylenetetrahydrofolate reductase Homo sapiens 88-93 14973091-10 2004 Results of this study suggest that the MTHFR C677T polymorphisms may modify the association between dietary folate intake and breast cancer risk. Folic Acid 108-114 methylenetetrahydrofolate reductase Homo sapiens 39-44 14973104-1 2004 5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism, diverting metabolites toward methylation reactions or nucleotide synthesis. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 14973104-7 2004 Stratification by nutrient intakes showed inverse associations with higher intakes of folate, vitamin B(2), B(6), B(12), and methionine among women with the MTHFR 677CC/1298AA genotypes, but not those with 677TT/1298AA. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 157-162 14734201-0 2004 Methylenetetrahydrofolate reductase (MTHFR) c677t gene variant modulates the homocysteine folate correlation in a mild folate-deficient population. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 14734201-3 2004 We investigated the influence of methylenetetrahydrofolate reductase (MTHFR) gene variants C677T, A1298C, and T1317C on homocysteine, folate, and cobalamin concentrations in a sample of individuals from a mild folate deficiency population to better clarify the complex interactions existing among these variables. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 70-75 14734201-11 2004 One may consider that a differential response of homocysteine to folic acid supplementation may depend on MTHFR genotype which may have important implications when attempting to lower homocysteine concentrations in populations with mild folate deficiency. Folic Acid 65-75 methylenetetrahydrofolate reductase Homo sapiens 106-111 15003888-1 2004 BACKGROUND AND OBJECTIVES: Methylenetetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and DNA methylation and synthesis. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 64-69 15228210-5 2004 In the female subjects, serum folate concentrations differed among MTHFR genotypes, being lowest in the VV group. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 67-72 15228210-8 2004 High folate and vitamin C consumptions, appears to be beneficial to normal and heterozygous MTHFR genotype subjects for maintaining serum folate concentrations. Folic Acid 5-11 methylenetetrahydrofolate reductase Homo sapiens 92-97 15228210-8 2004 High folate and vitamin C consumptions, appears to be beneficial to normal and heterozygous MTHFR genotype subjects for maintaining serum folate concentrations. Folic Acid 138-144 methylenetetrahydrofolate reductase Homo sapiens 92-97 15228210-9 2004 Even a 400 microg daily intake of folate might be less than what is needed, especially for homozygous MTHFR subjects and smokers, to maintain an adequate serum folate concentration. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 102-107 15228210-9 2004 Even a 400 microg daily intake of folate might be less than what is needed, especially for homozygous MTHFR subjects and smokers, to maintain an adequate serum folate concentration. Folic Acid 160-166 methylenetetrahydrofolate reductase Homo sapiens 102-107 14734703-2 2004 The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with changes in cellular composition of folates. Folic Acid 133-140 methylenetetrahydrofolate reductase Homo sapiens 30-65 14734703-2 2004 The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene is associated with changes in cellular composition of folates. Folic Acid 133-140 methylenetetrahydrofolate reductase Homo sapiens 67-72 14734703-8 2004 RESULTS: Compared with cells expressing the wild-type MTHFR, HCT116 and MDA-MB-435 cells expressing the mutant 677T MTHFR had decreased MTHFR activity, MTHFR thermolability, changed intracellular folate distribution, accelerated cellular growth rate, and increased thymidylate synthase activity. Folic Acid 196-202 methylenetetrahydrofolate reductase Homo sapiens 116-121 14734703-8 2004 RESULTS: Compared with cells expressing the wild-type MTHFR, HCT116 and MDA-MB-435 cells expressing the mutant 677T MTHFR had decreased MTHFR activity, MTHFR thermolability, changed intracellular folate distribution, accelerated cellular growth rate, and increased thymidylate synthase activity. Folic Acid 196-202 methylenetetrahydrofolate reductase Homo sapiens 116-121 14734703-8 2004 RESULTS: Compared with cells expressing the wild-type MTHFR, HCT116 and MDA-MB-435 cells expressing the mutant 677T MTHFR had decreased MTHFR activity, MTHFR thermolability, changed intracellular folate distribution, accelerated cellular growth rate, and increased thymidylate synthase activity. Folic Acid 196-202 methylenetetrahydrofolate reductase Homo sapiens 116-121 14734703-11 2004 CONCLUSIONS: Our data provide evidence that the MTHFR C677T polymorphism affects the concentration and intracellular distribution of folates and changes the growth and chemosensitivity of colon and breast cancer cells. Folic Acid 133-140 methylenetetrahydrofolate reductase Homo sapiens 48-53 14679361-9 2004 Serum homocysteine was negatively correlated with serum folate in all MTHFR genotypes (P<0.001), and the correlation between the two serum levels was the strongest in the T/T genotype. Folic Acid 56-62 methylenetetrahydrofolate reductase Homo sapiens 70-75 14679361-10 2004 Serum homocysteine was higher in the subjects with the T/T MTHFR genotype only when the serum folate was below the median level. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 59-64 14679361-13 2004 Higher serum folate, vitamin B2, and vitamin B12 concentrations may lessen the MTHFR genotypic effect on serum homocysteine levels. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 79-84 15583437-2 2004 In this respect, methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism that affects DNA methylation and synthesis. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 14663048-1 2003 OBJECTIVE: To evaluate whether hyperhomocysteinemia is an independent risk factor for silent brain infarction (SBI), and to determine the relationship between homocysteine and folate in each type of methylenetetrahydrofolate reductase (MTHFR) polymorphism, in order to identify a way of reducing the risk for SBI. Folic Acid 176-182 methylenetetrahydrofolate reductase Homo sapiens 199-234 14663048-5 2003 The homocysteine level showed a significant inverse correlation with folate level only in patients with SBI with the MTHFR 677TT genotype (p < 0.05). Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 117-122 14663048-6 2003 CONCLUSIONS: This study demonstrates that hyperhomocysteinemia is an independent risk factor for SBI, and provides the possibility of reducing the risk for SBI in the MTHFR 677TT genotype by folate supplementation. Folic Acid 191-197 methylenetetrahydrofolate reductase Homo sapiens 167-172 14676107-0 2003 The folate pool in colorectal cancers is associated with DNA hypermethylation and with a polymorphism in methylenetetrahydrofolate reductase. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 105-140 14639706-7 2003 We also looked for possible gene-gene interaction with the polymorphic variant C677T of the folic acid-metabolizing gene MTHFR. Folic Acid 92-102 methylenetetrahydrofolate reductase Homo sapiens 121-126 14714317-10 2003 An interaction between serum folate level and MTHFR genotype that affect the Hcy level is an important risk factor for DVT. Folic Acid 29-35 methylenetetrahydrofolate reductase Homo sapiens 46-51 14608052-1 2003 The C677T variant of methylenetetrahydrofolate reductase (MTHFR), a key enzyme in the remethylation of homocysteine to methionine, is a frequent genetic cause of mild hyperhomocysteinemia among individuals with low folate status. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 58-63 14608109-6 2003 Cancer risk may be increased in individuals with the homozygous genotype for the MTHFR 677C-->T polymorphism who have low status of methyl-related nutrients including folate. Folic Acid 170-176 methylenetetrahydrofolate reductase Homo sapiens 81-86 15004488-1 2003 The methylenetetrahydrofolate reductase (MTHFR) gene is a polymorphic gene involved in folate metabolism, DNA biosynthesis, methylation and genomic integrity in actively dividing cells. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 41-46 14572159-2 2003 A common 677C>T polymorphism in the gene for MTHFR, leading to a thermolabile enzyme with decreased activity, has been associated with reduced plasma folate levels and elevated homocysteine levels and could be a risk factor for breast cancer. Folic Acid 153-159 methylenetetrahydrofolate reductase Homo sapiens 48-53 12949355-9 2003 These data are consistent with the current understanding of the molecular interaction of the MTHFR mutant with folate substrates and the FAD prosthetic group. Folic Acid 111-117 methylenetetrahydrofolate reductase Homo sapiens 93-98 12897091-2 2003 The C677T polymorphism of the MTHFR gene has been reported to be associated with elevated plasma homocysteine in patients with low folic acid intake. Folic Acid 131-141 methylenetetrahydrofolate reductase Homo sapiens 30-35 12855225-2 2003 The first such sequence change was the 677C-->T substitution in methylenetetrahydrofolate reductase (MTHFR), but additional sequence changes have been identified in enzymes or transporters for folates. Folic Acid 196-203 methylenetetrahydrofolate reductase Homo sapiens 67-102 12855225-2 2003 The first such sequence change was the 677C-->T substitution in methylenetetrahydrofolate reductase (MTHFR), but additional sequence changes have been identified in enzymes or transporters for folates. Folic Acid 196-203 methylenetetrahydrofolate reductase Homo sapiens 104-109 12855226-17 2003 The biological implications of the limited number of MTHFR/MTHFR mutant alleles that can coexist, usually no more than two, may be explained by the serious consequences to folate status that these genotype combinations precipitate. Folic Acid 172-178 methylenetetrahydrofolate reductase Homo sapiens 53-58 12855226-17 2003 The biological implications of the limited number of MTHFR/MTHFR mutant alleles that can coexist, usually no more than two, may be explained by the serious consequences to folate status that these genotype combinations precipitate. Folic Acid 172-178 methylenetetrahydrofolate reductase Homo sapiens 59-64 12948423-4 2003 However, to serve as the active mediator, folate requires metabolism catalyzed by several enzymes including methylenetetrahydrofolate reductase (MTHFR), which plays a central role in biotransformation of folate. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 108-143 12948423-4 2003 However, to serve as the active mediator, folate requires metabolism catalyzed by several enzymes including methylenetetrahydrofolate reductase (MTHFR), which plays a central role in biotransformation of folate. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 145-150 12948423-4 2003 However, to serve as the active mediator, folate requires metabolism catalyzed by several enzymes including methylenetetrahydrofolate reductase (MTHFR), which plays a central role in biotransformation of folate. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 145-150 12801615-0 2003 Methylenetetrahydrofolate reductase (MTHFR) 677C>T and methionine synthase reductase (MTRR) 66A>G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid. Folic Acid 240-250 methylenetetrahydrofolate reductase Homo sapiens 0-35 12707953-2 2003 MTHFR plays a central role in the metabolism of folate. Folic Acid 48-54 methylenetetrahydrofolate reductase Homo sapiens 0-5 12730409-1 2003 A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C-->T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements. Folic Acid 51-57 methylenetetrahydrofolate reductase Homo sapiens 69-74 12730409-1 2003 A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C-->T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements. Folic Acid 207-213 methylenetetrahydrofolate reductase Homo sapiens 32-67 12730409-1 2003 A common genetic variant in the methylenetetrahydrofolate reductase (MTHFR) gene involving a cytosine to thymidine (C-->T) transition at nucleotide 677 is associated with reduced enzyme activity, altered folate status and potentially higher folate requirements. Folic Acid 207-213 methylenetetrahydrofolate reductase Homo sapiens 69-74 12730409-2 2003 The objectives of this study were to investigate the effect of the MTHFR 677 T allele on folate status variables in Mexican women (n = 43; 18-45 y) and to assess the adequacy of the 1998 folate U.S. Folic Acid 89-95 methylenetetrahydrofolate reductase Homo sapiens 67-72 12730409-10 2003 Collectively, these data demonstrate that the MTHFR C-->T variant modulates folate status response to controlled folate intakes and support the adequacy of the 1998 folate U.S. RDA for all three MTHFR C677T genotypes. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 46-51 12730409-10 2003 Collectively, these data demonstrate that the MTHFR C-->T variant modulates folate status response to controlled folate intakes and support the adequacy of the 1998 folate U.S. RDA for all three MTHFR C677T genotypes. Folic Acid 116-122 methylenetetrahydrofolate reductase Homo sapiens 46-51 12730410-1 2003 The 677 C-->T polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene interacts with folate status in determining elevated total plasma levels of homocysteine, a risk factor for coronary atherosclerotic disease (CAD). Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 79-84 12730410-4 2003 The MTHFR 677 C-->T genotype-specific threshold values of plasma folate corresponded to the 40th, 30th and 10th percentile in the TT, CT and CC genotype, respectively. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 4-9 12730410-7 2003 A gene-nutrient interaction that defines a higher risk for CAD is determined by folate levels below specific thresholds, which differ depending on the MTHFR 677 C-->T genotype. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 151-156 12672676-4 2003 Two MTHFR polymorphisms, C677T and A1298C, have been associated with reduced enzyme activity and C677T with altered distribution of intracellular folate metabolites. Folic Acid 146-152 methylenetetrahydrofolate reductase Homo sapiens 4-9 12672677-2 2003 Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene reduce availability of 5-methyltetrahydrofolate, the predominant circulating form of folate. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 58-63 12618331-1 2003 Methylenetetrahydrofolate reductase (MTHFR) is an essential enzyme in the folate metabolism, which affects DNA synthesis and methylation. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 12600862-0 2003 Effect of the methylenetetrahydrofolate reductase 677C-->T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 14-49 12600862-1 2003 BACKGROUND: Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate and homocysteine metabolism. Folic Acid 31-37 methylenetetrahydrofolate reductase Homo sapiens 49-54 12797455-1 2003 BACKGROUND: Several studies have suggested that homozygosity for the C677T 5,10-methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs), as individuals homozygous for the C677T allele have slightly elevated homocysteine concentrations under conditions of low folic acid intake. Folic Acid 313-323 methylenetetrahydrofolate reductase Homo sapiens 80-115 12797455-1 2003 BACKGROUND: Several studies have suggested that homozygosity for the C677T 5,10-methylenetetrahydrofolate reductase (MTHFR) variant is a potential risk factor for neural tube defects (NTDs), as individuals homozygous for the C677T allele have slightly elevated homocysteine concentrations under conditions of low folic acid intake. Folic Acid 313-323 methylenetetrahydrofolate reductase Homo sapiens 117-122 12797455-2 2003 It has been hypothesized that maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. Folic Acid 39-49 methylenetetrahydrofolate reductase Homo sapiens 112-117 12694231-2 2003 Methylenetetrahydrofolate reductase (MTHFR) is a candidate gene in the folate metabolism pathway that has been extensively studied in different human populations. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 12602921-1 2003 OBJECTIVE: Methylenetetrahydrofolate reductase (MTHFR), a polymorphic enzyme involved in folate metabolism, plays a role in DNA biosynthesis, methylation, and repair in actively dividing cells. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 48-53 12602921-10 2003 These findings should be explored with a larger sample size in order to analyze gene-environment interactions between MTHFR and folate. Folic Acid 128-134 methylenetetrahydrofolate reductase Homo sapiens 118-123 12560354-3 2003 Individuals with the MTHFR 677C-->T mutation have increased plasma total homocysteine (tHcy) concentrations, particularly in association with low folate status. Folic Acid 149-155 methylenetetrahydrofolate reductase Homo sapiens 21-26 12560354-10 2003 CONCLUSIONS: Folate and riboflavin interact to lower plasma tHcy, possibly by maximizing the catalytic activity of MTHFR. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 115-120 12690011-2 2003 Methylenetetrahydrofolate reductase (MTHFR) is a key regulatory enzyme in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 12690011-10 2003 CONCLUSIONS: The findings suggest an interaction between folate and the MTHFR genotype on colorectal adenomas. Folic Acid 57-63 methylenetetrahydrofolate reductase Homo sapiens 72-77 12499324-1 2003 BACKGROUND: Homozygotes for the thermolabile mutation (TT genotype) of the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) enzyme have elevated plasma concentrations of the cardiovascular disease risk factor homocysteine, particularly if folate depleted. Folic Acid 94-100 methylenetetrahydrofolate reductase Homo sapiens 112-117 14564626-11 2003 During human GI carcinogenesis, MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level, as well as aberrant methylation. Folic Acid 146-152 methylenetetrahydrofolate reductase Homo sapiens 32-37 12496052-9 2002 Our results suggest that variation at MTHFR codon 1298 (within the COOH-terminal region) may be more important for colon cancer than variation at codon 677 (NH(2)-terminal region), and in populations where folate intake is low, wild-type MTHFR activity may increase risk for colon cancer. Folic Acid 206-212 methylenetetrahydrofolate reductase Homo sapiens 38-43 12433726-1 2002 Methylenetetrahydrofolate reductase (MTHFR) plays a centralrole in converting folate to methyl donor for DNA methylation, an epigenetic modification known to be dysregulated in carcinogenesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 12204804-6 2002 These findings suggest that elevated homocysteine levels among Japanese with the homozygous genotype for the MTHFR gene mutation can be modified efficiently by dietary supplement of vitamin B12 as well as folate. Folic Acid 205-211 methylenetetrahydrofolate reductase Homo sapiens 109-114 12810987-5 2002 Ones of those are genes of metabolism of folic acid as MTHFR, MTR, MTRR, CBS, MTHFD, folic acid receptors (FR) regulator genes from PAX family, T, PDGFRA and BRCA1 genes. Folic Acid 41-51 methylenetetrahydrofolate reductase Homo sapiens 55-60 12237638-7 2002 For each genotype of methylenetetrahydrofolate reductase, lower levels of serum folate were observed in pregnant women who smoked, with the lowest folate levels seen in homozygous mutant methylenetetrahydrofolate reductase 677TT (18.6 nmol/L in pregnant women who smoked vs 24.2 nmol/L in pregnant women who did not smoke). Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 187-222 12237638-7 2002 For each genotype of methylenetetrahydrofolate reductase, lower levels of serum folate were observed in pregnant women who smoked, with the lowest folate levels seen in homozygous mutant methylenetetrahydrofolate reductase 677TT (18.6 nmol/L in pregnant women who smoked vs 24.2 nmol/L in pregnant women who did not smoke). Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 21-56 12237638-7 2002 For each genotype of methylenetetrahydrofolate reductase, lower levels of serum folate were observed in pregnant women who smoked, with the lowest folate levels seen in homozygous mutant methylenetetrahydrofolate reductase 677TT (18.6 nmol/L in pregnant women who smoked vs 24.2 nmol/L in pregnant women who did not smoke). Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 187-222 12163697-6 2002 Recently, an interaction was observed between folate status and a common mutation in the gene encoding for methylenetetrahydrofolate reductase, an essential enzyme in one-carbon metabolism, in determining genomic DNA methylation. Folic Acid 46-52 methylenetetrahydrofolate reductase Homo sapiens 107-142 12163703-6 2002 The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 178-213 12163703-6 2002 The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 215-220 12163703-6 2002 The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 333-338 12163703-6 2002 The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis. Folic Acid 197-203 methylenetetrahydrofolate reductase Homo sapiens 215-220 12163703-6 2002 The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis. Folic Acid 197-203 methylenetetrahydrofolate reductase Homo sapiens 333-338 12163703-6 2002 The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis. Folic Acid 197-203 methylenetetrahydrofolate reductase Homo sapiens 215-220 12163703-6 2002 The hypothesis that these two pathways are the means by which folate modulates cancer risk is also supported by the epidemiological observation that a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR; EC 1.5.1.20) gene differentially affects the relative risk of colon cancer depending on folate status, because MTHFR catalyzes the reaction that determines whether cellular folate is diverted into biological methylation or nucleotide synthesis. Folic Acid 197-203 methylenetetrahydrofolate reductase Homo sapiens 333-338 12175537-1 2002 Methylenetetrahydrofolate reductase (MTHFR) plays a pivotal role in folate metabolism by regulating the diversion of folate metabolites toward DNA methylation or toward DNA synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 12175537-1 2002 Methylenetetrahydrofolate reductase (MTHFR) plays a pivotal role in folate metabolism by regulating the diversion of folate metabolites toward DNA methylation or toward DNA synthesis. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 0-35 12175537-1 2002 Methylenetetrahydrofolate reductase (MTHFR) plays a pivotal role in folate metabolism by regulating the diversion of folate metabolites toward DNA methylation or toward DNA synthesis. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 37-42 12175537-4 2002 Thus, rapid identification of both polymorphisms in MTHFR gene would be of importance in understanding the genetics of abnormal folate metabolism as related to human cancer risk. Folic Acid 128-134 methylenetetrahydrofolate reductase Homo sapiens 52-57 12430180-2 2002 The methylenetetrahydrofolate reductase gene (MTHFR), which has a key role in folate metabolism, is polymorphic. Folic Acid 23-29 methylenetetrahydrofolate reductase Homo sapiens 46-51 12430180-3 2002 We report a case-control study of two functional polymorphisms in MTHFR, dietary folate intake and breast cancer. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 66-71 12081832-0 2002 Methylenetetrahydrofolate reductase 677C-->T genotype modulates homocysteine responses to a folate-rich diet or a low-dose folic acid supplement: a randomized controlled trial. Folic Acid 126-136 methylenetetrahydrofolate reductase Homo sapiens 0-35 12049616-8 2002 TT homozygosity at residue 677 was associated with elevation of total erythrocyte folate compared with both other genotypes (P<0.0001), almost certainly due to the diversion of 5,10-methylenetetrahydrofolate into derivates subsequent to the partial metabolic block that results from the MTHFR enzyme defect. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 290-295 12049616-10 2002 The MTHFR genotype does not significantly influence either plasma homocysteine or vascular disease, despite it being a determinant of erythrocyte folate, which reflects its effect on folate metabolism. Folic Acid 146-152 methylenetetrahydrofolate reductase Homo sapiens 4-9 12049616-10 2002 The MTHFR genotype does not significantly influence either plasma homocysteine or vascular disease, despite it being a determinant of erythrocyte folate, which reflects its effect on folate metabolism. Folic Acid 183-189 methylenetetrahydrofolate reductase Homo sapiens 4-9 12020105-6 2002 CONCLUSIONS: This study provides additional evidence for a decreased CRC risk for subjects with the MTHFR 677T allele, particularly at high levels of folate and vitamin B6 intake. Folic Acid 150-156 methylenetetrahydrofolate reductase Homo sapiens 100-105 11956665-9 2002 The sufficiently high dose of folate seems to be able to decrease plasma tHcy in all three individual MTHFR polymorphism groups, to almost the same post-treatment concentrations. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 102-107 11889073-1 2002 BACKGROUND: The enzyme methylenetetrahydrofolate reductase (MTHFR) catalyses the formation of folate intermediates that are vital to methylation reactions. Folic Acid 42-48 methylenetetrahydrofolate reductase Homo sapiens 60-65 11889073-12 2002 CONCLUSIONS: The TT genotype of MTHFR is associated with an increased risk of CRC in older populations, possibly due to age related disturbances in folate metabolism. Folic Acid 148-154 methylenetetrahydrofolate reductase Homo sapiens 32-37 11927833-1 2002 5,10-Methylenetetrahydrofolate reductase (MTHFR), a key enzyme involved in folate metabolism, has two common polymorphisms that affect enzyme activity. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 11872199-1 2002 OBJECTIVE: To evaluate the relationships among the methylenetetrahydrofolate reductase (MTHFR) polymorphism, plasma folate, total homocysteine (Hcy) levels, lipids, and the reduction of Hcy levels resulting from hormone replacement therapy (HRT). Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 88-93 12013675-1 2002 Homozygosity for a common polymorphism in the 5,10 methylenetetrahydrofolate reductase (MTHFR) gene (C677T) has been associated to an increased risk of neural tube defects as well as derangements in folate, homocysteine, and hematological parameters. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 88-93 11863127-3 2002 A homozygous C677T MTHFR was found with low folate status. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 19-24 11863127-8 2002 We propose mild or moderate hyperhomocysteinemia triggered by low folate status in patients with homozygous C677T MTHFR as a cause of renal arterial thrombosis. Folic Acid 66-72 methylenetetrahydrofolate reductase Homo sapiens 114-119 11938441-6 2002 The present finding of high prevalence of mutated MTHFR genotypes in spontaneously aborted embryos emphasises the potential protective role of periconceptional folic acid supplementation. Folic Acid 160-170 methylenetetrahydrofolate reductase Homo sapiens 50-55 11823591-2 2002 The C677T MTHFR polymorphism is associated with mild hyperhomocysteinemia, but only in the presence of low folate status. Folic Acid 107-113 methylenetetrahydrofolate reductase Homo sapiens 10-15 12001978-10 2002 Homozygotes for variant MTHFR had higher homocysteine concentrations at low plasma folate (P < 0.01). Folic Acid 83-89 methylenetetrahydrofolate reductase Homo sapiens 24-29 11807890-1 2002 Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 64-99 11807890-1 2002 Polymorphisms in genes encoding the folate metabolizing enzymes methylenetetrahydrofolate reductase (MTHFR C677T) and methionine synthase reductase (MTRR A66G) have been linked to the etiology of Down syndrome. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 101-106 23105344-3 2002 A common mutation (C677T) in the gene encoding for the enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) or deficiency of the B vitamins namely folic acid, B(12), B(6) can lead to hyperhomocysteinemia.In the present study, we have investigated the incidence of the (C677T) MTHFR polymorphism in the North Indian males. Folic Acid 151-161 methylenetetrahydrofolate reductase Homo sapiens 105-110 23105344-3 2002 A common mutation (C677T) in the gene encoding for the enzyme 5, 10-methylenetetrahydrofolate reductase (MTHFR) or deficiency of the B vitamins namely folic acid, B(12), B(6) can lead to hyperhomocysteinemia.In the present study, we have investigated the incidence of the (C677T) MTHFR polymorphism in the North Indian males. Folic Acid 151-161 methylenetetrahydrofolate reductase Homo sapiens 280-285 11918280-7 2001 Moreover, patients with MTHFR A/A genotype showed a poorer folate status than control subjects, suggesting that a subclinical folate deficiency may be very frequent in renal artery stenosis, regardless of C677T mutation. Folic Acid 59-65 methylenetetrahydrofolate reductase Homo sapiens 24-29 11918280-7 2001 Moreover, patients with MTHFR A/A genotype showed a poorer folate status than control subjects, suggesting that a subclinical folate deficiency may be very frequent in renal artery stenosis, regardless of C677T mutation. Folic Acid 126-132 methylenetetrahydrofolate reductase Homo sapiens 24-29 11813127-3 2001 The C677 T variant of the MTHFR gene coding for a thermolabile enzyme has been described as the first genetic risk factor that accounts for a group of NTDs characterized by low maternal folate status and high homocysteine concentrations. Folic Acid 186-192 methylenetetrahydrofolate reductase Homo sapiens 26-31 11738277-3 2001 Individuals homozygous (TT) for the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene ( approximately 12% of the population) have increased homocysteine levels, particularly in association with suboptimal folate intake. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 95-100 11744407-7 2001 When the study population was divided into 2 groups accordingly to serum folate levels (above/below the median value of 6.1 ng/ml), MTHFR genotype remained a significant predictor of homocysteine only in patients with low serum folate (p = 0.048). Folic Acid 228-234 methylenetetrahydrofolate reductase Homo sapiens 132-137 11584084-6 2001 Compared with the low folate diet, the high folate diet increased the serum folate concentration by 85% (P < 0.001), 77% (P < 0.001) and 55% (P < 0.05) in the subjects with the genotypes C/C (n = 19), C/T (n = 13) and T/T (n = 5), respectively, of the MTHFR gene. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 261-266 11584084-6 2001 Compared with the low folate diet, the high folate diet increased the serum folate concentration by 85% (P < 0.001), 77% (P < 0.001) and 55% (P < 0.05) in the subjects with the genotypes C/C (n = 19), C/T (n = 13) and T/T (n = 5), respectively, of the MTHFR gene. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 261-266 11494235-2 2001 The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 11494235-2 2001 The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 142-147 11494235-2 2001 The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 4-44 11494235-2 2001 The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 46-51 11494235-2 2001 The 5,10-methylenetetrahydrofolate reductase (MTHFR) involved in folate metabolism has 2 variants, C677T and A1298C, that result in decreased MTHFR activity and lower plasma folate levels. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 142-147 11759174-7 2001 The effect of folate seems to be modulated by alcohol, methionine, and MTHFR polymorphisms. Folic Acid 14-20 methylenetetrahydrofolate reductase Homo sapiens 71-76 11443546-2 2001 Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 113-148 11443546-2 2001 Thus, recent reports linking Down syndrome to maternal polymorphisms at either of two folate metabolism enzymes, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), have generated considerable interest. Folic Acid 86-92 methylenetetrahydrofolate reductase Homo sapiens 150-155 11519232-11 2001 As for the genetic polymorphism of the V677 gen of the metylenetetrahydrofolate-reductase (MTHFR) enzyme there was a significant correlation with homocysteine level (r = 0.436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354). Folic Acid 246-256 methylenetetrahydrofolate reductase Homo sapiens 55-89 11519232-11 2001 As for the genetic polymorphism of the V677 gen of the metylenetetrahydrofolate-reductase (MTHFR) enzyme there was a significant correlation with homocysteine level (r = 0.436, p = 0.010), and a negative, but not significant correlation with the folic acid level (r = -0.354). Folic Acid 246-256 methylenetetrahydrofolate reductase Homo sapiens 91-96 11431185-4 2001 Multiple stepwise regression analysis showed that the MTHFR 677C-->T/1298A-->C genotype (CC/AA, CC/AC, CC/CC, CT/AA, CT/AC, TT/AA), vitamin use, age, folate and vitamin B(12) plasma level were significant predictors of tHcy plasma levels. Folic Acid 156-162 methylenetetrahydrofolate reductase Homo sapiens 54-59 11424140-9 2001 In conclusion, in smokers, high folate status may confer increased or decreased risk for HRAs, depending on the MTHFR genotype. Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 112-117 11433922-1 2001 MTHFR encodes a critical enzyme in folate and homocysteine metabolism and the C677T allele of the MTHFR gene has some association with an increased risk for neural-tube defects and for adult cardiovascular diseases. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 0-5 11433922-1 2001 MTHFR encodes a critical enzyme in folate and homocysteine metabolism and the C677T allele of the MTHFR gene has some association with an increased risk for neural-tube defects and for adult cardiovascular diseases. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 98-103 11398138-8 2001 The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR), a key enzyme of folate and homocysteine metabolism, was determined by polymerase chain reaction (PCR) with restriction enzyme analysis. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 67-72 11273876-5 2001 A high baseline tHcy plasma concentration (P: = 0.00001), methylenetetrahydrofolate reductase (MTHFR) 677TT/1298AA genotype (P: = 0.03540), and low red blood cell folate concentrations (P: = 0.02285) were associated with a better relative response to treatment. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 95-100 11319182-2 2001 Methylene-tetrahydrofolate reductase (MTHFR) is one of the enzymes involved in folate metabolism and is thought to influence DNA methylation and nucleotide synthesis. Folic Acid 20-26 methylenetetrahydrofolate reductase Homo sapiens 38-43 11319182-3 2001 MTHFR is highly polymorphic, and the variant genotypes result in decreased MTHFR enzyme activity and lower plasma folate level. Folic Acid 114-120 methylenetetrahydrofolate reductase Homo sapiens 0-5 11368417-7 2001 Thus, a dysfunctional MTHFR partly explains the observed elevated Hcy levels in women with NTD pregnancies and also, in part, the protective effect of folate on NTD. Folic Acid 151-157 methylenetetrahydrofolate reductase Homo sapiens 22-27 11282420-1 2001 The enzyme methylenetetrahydrofolate reductase (MTHFR) directs folate species either to DNA synthesis or to homocysteine (Hcy) remethylation. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 48-53 11282420-2 2001 The common MTHFR C677T polymorphism affects the activity of the enzyme and hence folate distribution. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 11-16 11282420-4 2001 The MTHFR C677T polymorphism shows no consistent correlation with cardiovascular risk and longevity but, in combination with positive folate balance, the TT genotype is associated with decreased risk of colorectal neoplasias. Folic Acid 134-140 methylenetetrahydrofolate reductase Homo sapiens 4-9 11274424-1 2001 Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 105-140 11274424-1 2001 Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers. Folic Acid 4-10 methylenetetrahydrofolate reductase Homo sapiens 142-147 11274424-1 2001 Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 105-140 11274424-1 2001 Low folate intake as well as alterations in folate metabolism as a result of polymorphisms in the enzyme methylenetetrahydrofolate reductase (MTHFR) have been associated with an increased incidence of neural tube defects, vascular disease, and some cancers. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 142-147 11161947-2 2001 Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C allele exclusively accumulate 5methyltetrahydrofolate, the methyl donor for homocysteine remethylation, in their red blood cells; this contrasts with 677 TT homozygotes who also accumulate significant levels of non-methylated folate derivatives. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 68-73 11161947-3 2001 Those with the MTHFR 677 TT, CT and CC genotypes may therefore differ qualitatively with respect to folate utilization and hence their capacity to remethylate homocysteine. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 15-20 11261364-5 2001 There are recent reports that folic acid metabolism is also altered by other hereditary variations of MTHFR and other enzymes involved in folic acid metabolism. Folic Acid 30-40 methylenetetrahydrofolate reductase Homo sapiens 102-107 11261364-5 2001 There are recent reports that folic acid metabolism is also altered by other hereditary variations of MTHFR and other enzymes involved in folic acid metabolism. Folic Acid 138-148 methylenetetrahydrofolate reductase Homo sapiens 102-107 11169018-3 2001 Furthermore, compound heterozygosity for the 677T allele and a novel A-->C polymorphism at nucleotide position 1298 of MTHFR is suggested to correlate with a decrease of folate plasma concentrations. Folic Acid 173-179 methylenetetrahydrofolate reductase Homo sapiens 122-127 14728017-12 2001 However, hyperhomocysteinemia because of the C677T MTHFR allele may be corrected with oral folic acid therapy. Folic Acid 91-101 methylenetetrahydrofolate reductase Homo sapiens 51-56 11680544-2 2001 Methylenetetrahydrofolate reductase (MT-HFR) is a key enzyme involved in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-43 11468972-7 2001 The procedure recommended for the prevention of effects of deficiency of MTHFR activity consists of the supplementation of the diet with 0.4 mg of folic acid daily. Folic Acid 147-157 methylenetetrahydrofolate reductase Homo sapiens 73-78 11204591-9 2001 This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate. Folic Acid 247-253 methylenetetrahydrofolate reductase Homo sapiens 42-47 11177206-15 2000 Thus, the interaction of dietary folate with the MTHFR genotype in the French population needs further study. Folic Acid 33-39 methylenetetrahydrofolate reductase Homo sapiens 49-54 11147289-9 2000 The study of folate and its association with NTDs is an ongoing endeavor that has led to numerous studies of different genes involved in the folate metabolism pathway, including the most commonly studied thermolabile mutation (C677T) in the MTHFR gene. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 241-246 11147289-9 2000 The study of folate and its association with NTDs is an ongoing endeavor that has led to numerous studies of different genes involved in the folate metabolism pathway, including the most commonly studied thermolabile mutation (C677T) in the MTHFR gene. Folic Acid 141-147 methylenetetrahydrofolate reductase Homo sapiens 241-246 11062308-3 2000 A common genetic variant of the methylenetetrahydrofolate reductase (MTHFR) gene CC 677 T) is associated with thermolability of the MTHFR enzyme and elevated plasma homocysteine concentration, especially in those with low folic acid concentration. Folic Acid 222-232 methylenetetrahydrofolate reductase Homo sapiens 32-67 11062308-3 2000 A common genetic variant of the methylenetetrahydrofolate reductase (MTHFR) gene CC 677 T) is associated with thermolability of the MTHFR enzyme and elevated plasma homocysteine concentration, especially in those with low folic acid concentration. Folic Acid 222-232 methylenetetrahydrofolate reductase Homo sapiens 69-74 11062308-3 2000 A common genetic variant of the methylenetetrahydrofolate reductase (MTHFR) gene CC 677 T) is associated with thermolability of the MTHFR enzyme and elevated plasma homocysteine concentration, especially in those with low folic acid concentration. Folic Acid 222-232 methylenetetrahydrofolate reductase Homo sapiens 132-137 11004224-7 2000 BMI, creatinine clearance, ln-tHcy, and MTHFR genotype influenced ln-folate (lower folate levels for MTHFR 677TT/1298AA versus all other genotype groups: P < 0.05). Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 40-45 11004224-7 2000 BMI, creatinine clearance, ln-tHcy, and MTHFR genotype influenced ln-folate (lower folate levels for MTHFR 677TT/1298AA versus all other genotype groups: P < 0.05). Folic Acid 69-75 methylenetetrahydrofolate reductase Homo sapiens 101-106 11004224-10 2000 This study shows that the MTHFR 677TT/1298AA and 677CT/1298AC genotypes are significant predictors of tHcy and folate plasma levels. Folic Acid 111-117 methylenetetrahydrofolate reductase Homo sapiens 26-31 10919734-8 2000 These data are consistent with an interaction between MTHFR genotype and folate availability. Folic Acid 73-79 methylenetetrahydrofolate reductase Homo sapiens 54-59 10941256-2 2000 In some cancers, folate and other nutrients involved in the MTHFR metabolic pathway appear to interact with MTHFR polymorphisms to further modify cancer risk. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 60-65 10941256-2 2000 In some cancers, folate and other nutrients involved in the MTHFR metabolic pathway appear to interact with MTHFR polymorphisms to further modify cancer risk. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 108-113 10928104-13 2000 Since MTHFR polymorphism and pregnancy increases folate requirements and can impair folate status, this association could reflect an inadequate response of mutant MTHFR genotype carriers to the increased demand for folate imposed by pregnancy. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 6-11 10928104-13 2000 Since MTHFR polymorphism and pregnancy increases folate requirements and can impair folate status, this association could reflect an inadequate response of mutant MTHFR genotype carriers to the increased demand for folate imposed by pregnancy. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 6-11 10928104-13 2000 Since MTHFR polymorphism and pregnancy increases folate requirements and can impair folate status, this association could reflect an inadequate response of mutant MTHFR genotype carriers to the increased demand for folate imposed by pregnancy. Folic Acid 84-90 methylenetetrahydrofolate reductase Homo sapiens 6-11 10830195-1 2000 The aim of this study was to investigate a possible association among the thermolabile polymorphism, nucleotide 677 cytosine to thymidine point mutation (677 C-->T) of the methylenetetrahydrofolate reductase (MTHFR) gene, hyperhomocysteinemia, serum folate, vitamins B12 and B6, and stroke in children. Folic Acid 194-200 methylenetetrahydrofolate reductase Homo sapiens 212-217 10833329-11 2000 When broken down into the various 677 ct MTHFR and 2756ag MetSyn genotypes, carriage of the 677ct MTHFR allele appears to affect formyl-H(4)PteGlu metabolism in non-NTD mothers. Folic Acid 140-146 methylenetetrahydrofolate reductase Homo sapiens 98-103 10780318-9 2000 In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p < or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p < or =0.028). Folic Acid 193-199 methylenetetrahydrofolate reductase Homo sapiens 173-178 10780318-9 2000 In a generalized linear model, 44% of the variation in tHcy levels was explained by folate and vitamin B12 levels, the MTHFR genotype, gender, and by the interaction of the MTHFR genotype with folate (p < or =0.028); the interactions of vitamin B12 with the MTHFR genotype, gender and patient/control status also significantly contributed to the variation in tHcy levels (p < or =0.028). Folic Acid 193-199 methylenetetrahydrofolate reductase Homo sapiens 173-178 10780318-11 2000 Subjects carrying the MTHFR 677TT genotype have higher folate and vitamin B12 requirements irrespective of the A2756G polymorphism of the MS gene. Folic Acid 55-61 methylenetetrahydrofolate reductase Homo sapiens 22-27 10884945-4 2000 The relationship between the methylenetetrahydrofolate reductase gene and dietary folate is an example of a diet-gene interaction that involves a polymorphism in a vitamin metabolism gene, and the presence of the variant appears to influence both risk for cancer and folate requirements. Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 29-64 11214939-3 2000 The underlying basis is a derangement of homocysteine metabolism due to a missense mutation of the MTHFR enzyme that has to catalyze the folate metabolic cycle furnishing sufficient methyl groups for DNA and tRNA synthesis. Folic Acid 137-143 methylenetetrahydrofolate reductase Homo sapiens 99-104 11214939-4 2000 Folate can overcome the dysfunction of the mutation and the decreased activity of the thermolabile MTHFR. Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 99-104 11277368-8 2000 The lowering action of carbamazepine treatment on folate levels seems to be associated with hyperhomocysteinaemia, which seems to be related to the homozygous condition for the MTHFR 677C-->T mutation. Folic Acid 50-56 methylenetetrahydrofolate reductase Homo sapiens 177-182 10695265-0 2000 The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T). Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 100-135 10695265-0 2000 The relation between erythrocyte volume and folate levels is influenced by a common mutation in the methylenetetrahydrofolate reductase (MTHFR) gene (C677T). Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 137-142 10695265-1 2000 BACKGROUND: The enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and folate-dependent reactions. Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 65-70 10695265-1 2000 BACKGROUND: The enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and folate-dependent reactions. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 28-63 10695265-1 2000 BACKGROUND: The enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) plays an important role in folate metabolism and folate-dependent reactions. Folic Acid 99-105 methylenetetrahydrofolate reductase Homo sapiens 65-70 10695265-2 2000 Homozygosity for a common polymorphism in the MTHFR gene (C677T, Ala to Val) is associated with an increased risk of neural tube defects and hyperhomocysteinemia in individuals with low folate levels. Folic Acid 186-192 methylenetetrahydrofolate reductase Homo sapiens 46-51 11040276-9 2000 These findings have been bolstered by an association between incidence of colon cancer and a polymorphism in the gene for methylenetetrahydrofolate reductase, an enzyme involved in folic acid metabolism. Folic Acid 181-191 methylenetetrahydrofolate reductase Homo sapiens 122-157 11011843-4 2000 The best example of this concept is a missense mutation (alanine to valine) at base pair (bp) 677 of methylenetetrahydrofolate reductase (MTHFR), the enzyme that provides the folate derivative for conversion of homocysteine to methionine. Folic Acid 120-126 methylenetetrahydrofolate reductase Homo sapiens 138-143 10536004-10 1999 Individuals with the MTHFR 677TT, 1298AC, and 1298CC genotypes have a decreased risk of adult ALL, but not acute myeloid leukemia, which suggests that folate inadequacy may play a key role in the development of ALL. Folic Acid 151-157 methylenetetrahydrofolate reductase Homo sapiens 21-26 10500018-9 1999 CONCLUSION: The results of this initial study indicate that folate metabolism is abnormal in mothers of children with Down syndrome and that this may be explained, in part, by a mutation in the MTHFR gene. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 194-199 10440833-1 1999 Folic acid can prevent neural tube defects; in some cases the mechanism is probably a correction of a metabolic defect caused by thermolabile methylenetetrahydrofolate reductase (MTHFR) found in increased frequency in cases. Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 142-177 10440833-1 1999 Folic acid can prevent neural tube defects; in some cases the mechanism is probably a correction of a metabolic defect caused by thermolabile methylenetetrahydrofolate reductase (MTHFR) found in increased frequency in cases. Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 179-184 10440833-8 1999 In the Irish population homozygosity for the common folate-related polymorphism associated with thermolabile MTHFR is significantly more frequent in those with isolated cleft palate, and could be etiologically important. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 109-114 10460200-3 1999 In the current study, we determined the prevalence of a newly described mutation in the human MTHFR gene A1298C, and the already known C677T mutation, and related them to plasma total homocysteine and folate concentrations. Folic Acid 201-207 methylenetetrahydrofolate reductase Homo sapiens 94-99 10430972-1 1999 The purpose of this study is to observe the influence of the methylenetetrahydrofolate reductase (MTHFR) gene (677C-->T substitution) on plasma homocysteine levels in end-stage renal disease (ESRD) patients who received a relatively large amount of folate (2 mg/d) and are undergoing hemodialysis. Folic Acid 80-86 methylenetetrahydrofolate reductase Homo sapiens 98-103 10744125-6 1999 The associations between dietary intakes of folate, vitamin B12, vitamin B6, or methionine and risk of adenomas showed consistent patterns dependent upon MTHFR genotype. Folic Acid 44-50 methylenetetrahydrofolate reductase Homo sapiens 154-159 10744125-11 1999 Low intakes of folate, vitamin B12, and vitamin B6 increase risk among those (particularly the elderly) with the MTHFR TT genotype. Folic Acid 15-21 methylenetetrahydrofolate reductase Homo sapiens 113-118 10459572-2 1999 To determine whether a common methylenetetrahydrofolate reductase (MTHFR) variant is related to elevated homocysteine concentrations in epileptic patients receiving anticonvulsants, we investigated the plasma total homocysteine (tHcy) level, folate level, and MTHFR 677 C --> T mutation using a polymerase chain reaction (PCR) and restriction fragment length polymorphism analysis with HinfI digestion in 103 patients with epilepsy and 103 normal controls. Folic Acid 49-55 methylenetetrahydrofolate reductase Homo sapiens 67-72 10459572-4 1999 The homozygosity for the 677 C --> T mutation of MTHFR was associated with elevated tHcy and low folate levels. Folic Acid 100-106 methylenetetrahydrofolate reductase Homo sapiens 52-57 10397696-12 1999 We conclude that in patients with VTE who do not have coexisting prothrombotic defects, hyperhomocystinemia increases the risk of developing idiopathic and venous thrombosis; the homozygous condition for the MTHFR mutation confers a moderate risk but, together with low folate levels, it is the main determinant of mild hyperhomocystinemia in normal and thromboembolic populations. Folic Acid 270-276 methylenetetrahydrofolate reductase Homo sapiens 208-213 10385141-8 1999 Although associations were generally weak, these findings suggest that those with differing MTHFR genotypes may have different susceptibilities to colon cancer, based on dietary consumption of folate, vitamin B6, and vitamin B12. Folic Acid 193-199 methylenetetrahydrofolate reductase Homo sapiens 92-97 10323785-7 1999 An interaction was found between MTHFR TT genotype and serum folate levels for both fasting and post-methionine tHcy, ie, for a given decrease in serum folate, homocysteine levels increased more in subjects with the TT genotype than in those with the CC genotype. Folic Acid 61-67 methylenetetrahydrofolate reductase Homo sapiens 33-38 10323785-7 1999 An interaction was found between MTHFR TT genotype and serum folate levels for both fasting and post-methionine tHcy, ie, for a given decrease in serum folate, homocysteine levels increased more in subjects with the TT genotype than in those with the CC genotype. Folic Acid 152-158 methylenetetrahydrofolate reductase Homo sapiens 33-38 10323785-11 1999 We also found evidence, in patients with premature vascular disease but not in their healthy siblings, for a factor that increases tHcy levels but weakens the normal inverse relation between folate and tHcy and amplifies the effect of the MTHFR genotype. Folic Acid 191-197 methylenetetrahydrofolate reductase Homo sapiens 239-244 10212171-1 1999 OBJECTIVE: To determine the effects of the thermolabile methylene tetrahydrofolate reductase (MTHFR) mutation on the presence and extent of coronary atherosclerosis in a population with low plasma folate. Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 94-99 10222379-5 1999 The complex interaction between this common genetic polymorphism of MTHFR and folate intake is the focus of intense investigation. Folic Acid 78-84 methylenetetrahydrofolate reductase Homo sapiens 68-73 10090889-8 1999 These results favor a biological model of MTHFR-related NTD pathogenesis in which suboptimal maternal folate status imposes biochemical stress on the developing embryo, a stress it is ill-equipped to tolerate if it has a TT genotype. Folic Acid 102-108 methylenetetrahydrofolate reductase Homo sapiens 42-47 10201405-3 1999 The flavoprotein methylenetetrahydrofolate reductase (MTHFR) is a likely target for these actions of folate. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 54-59 10201405-9 1999 Folate derivatives protect wild-type and mutant E. coli enzymes against flavin loss, and protect human MTHFR and the A222V mutant against thermal inactivation, suggesting a mechanism by which folate treatment reduces homocysteine levels. Folic Acid 192-198 methylenetetrahydrofolate reductase Homo sapiens 103-108 9974399-2 1999 Homozygosity for the C677T mutation in the gene for 5,10-methylenetetrahydrofolate reductase (MTHFR) is frequently associated with hyperhomocysteinemia, particularly in individuals with low levels of serum folate, and has been directly associated with cardiovascular disease in certain populations. Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 94-99 10100295-6 1999 Homocysteine levels should be measured in patients with chronic renal failure, since simple and safe treatment with folic acid and vitamin B12 is effective in lowering the plasma homocysteine level in patients with the thermolabile MTHFR allele. Folic Acid 116-126 methylenetetrahydrofolate reductase Homo sapiens 232-237 9843457-2 1998 Recently, a mutation (677C-->T) was identified in the methylenetetrahydrofolate reductase (MTHFR) gene that results in reduced folate-dependent enzyme activity and reduced remethylation of homocysteine to methionine. Folic Acid 76-82 methylenetetrahydrofolate reductase Homo sapiens 94-99 9843036-2 1998 Because of MTHFR"s involvement with folate metabolism and evidence that maternal use of a multivitamin with folic acid in early pregnancy reduces risk for cleft lip with or without cleft palate (CLP), we hypothesized that infants homozygous for the C677T genotype would be at increased risk for CLP because of lower MTHFR enzymatic activity. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 11-16 9843036-2 1998 Because of MTHFR"s involvement with folate metabolism and evidence that maternal use of a multivitamin with folic acid in early pregnancy reduces risk for cleft lip with or without cleft palate (CLP), we hypothesized that infants homozygous for the C677T genotype would be at increased risk for CLP because of lower MTHFR enzymatic activity. Folic Acid 108-118 methylenetetrahydrofolate reductase Homo sapiens 316-321 9863549-12 1998 In addition, the MTHFR genotype seems important for the inverse relationship between homocysteine and folate and vitamin B12 levels. Folic Acid 102-108 methylenetetrahydrofolate reductase Homo sapiens 17-22 9863549-15 1998 Moreover, the plasma level of folate, which by itself influences homocysteine levels, is also dependent on the MTHFR genotype. Folic Acid 30-36 methylenetetrahydrofolate reductase Homo sapiens 111-116 9789068-5 1998 Existence of formylated folates in RBCs only from individuals with the thermolabile MTHFR is consistent with the hypothesis that there is in vivo impairment in the activity of the thermolabile variant of MTHFR and that this impairment results in an altered distribution of RBC folates. Folic Acid 24-31 methylenetetrahydrofolate reductase Homo sapiens 84-89 9789068-5 1998 Existence of formylated folates in RBCs only from individuals with the thermolabile MTHFR is consistent with the hypothesis that there is in vivo impairment in the activity of the thermolabile variant of MTHFR and that this impairment results in an altered distribution of RBC folates. Folic Acid 24-31 methylenetetrahydrofolate reductase Homo sapiens 204-209 9663401-4 1998 It has been hypothesized that maternal folic acid supplementation prevents NTDs by partially correcting reduced MTHFR activity associated with the variant form of the enzyme. Folic Acid 39-49 methylenetetrahydrofolate reductase Homo sapiens 112-117 9596662-8 1998 A genotype/phenotype correlation study showed a marked effect of folate on the association between MTHFR genotypes and tHcy. Folic Acid 65-71 methylenetetrahydrofolate reductase Homo sapiens 99-104 9607212-7 1998 Folate levels in peritoneal dialysis patients were significantly affected by the MTHFR genotype (P = 0.016). Folic Acid 0-6 methylenetetrahydrofolate reductase Homo sapiens 81-86 9781030-2 1998 MTHFR is a key enzyme in folate-dependent remethylation of homocysteine, and reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 0-5 9562260-9 1998 In conclusion, the associations of creatinine levels and, inversely, of folate levels with plasma homocyst(e)ine levels in patients with TIA or MS are dependent on the 5,10-MTHFR mutation status. Folic Acid 72-78 methylenetetrahydrofolate reductase Homo sapiens 173-178 9622772-1 1998 OBJECTIVE: In the presence of low serum folate, mutant 5,20-methylenetetrahydrofolate reductase (MTHFR + [A223V/C677T]) in the homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD). Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 60-95 9622772-1 1998 OBJECTIVE: In the presence of low serum folate, mutant 5,20-methylenetetrahydrofolate reductase (MTHFR + [A223V/C677T]) in the homozygous state (+/+), may predispose to higher plasma homocysteine (tHct) levels and coronary artery disease (CAD). Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 97-102 9622772-11 1998 A significant relation was shown between MTHFR genotype and low folate status yielding high tHct levels in those with the (+/+) genotype. Folic Acid 64-70 methylenetetrahydrofolate reductase Homo sapiens 41-46 11309278-1 2001 Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism that affects DNA methylation and synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 11337744-5 2001 We suggest that homozygosity for the MTHFR mutation may be a risk factor for transverse terminal limb defect/s by an effect mediated through altered folate and homocysteine metabolism. Folic Acid 149-155 methylenetetrahydrofolate reductase Homo sapiens 37-42 11303694-2 2001 A common mutation (nucleotid 677C-T) in the gene coding for methylenetetrahydrofolate reductase (MTHFR) has been reported to reduce the enzymatic activity of MTHFR and is associated with elevated plasma levels of homocysteine, especially in subjects with low folate intake. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 97-102 11303694-2 2001 A common mutation (nucleotid 677C-T) in the gene coding for methylenetetrahydrofolate reductase (MTHFR) has been reported to reduce the enzymatic activity of MTHFR and is associated with elevated plasma levels of homocysteine, especially in subjects with low folate intake. Folic Acid 79-85 methylenetetrahydrofolate reductase Homo sapiens 158-163 11157318-9 2001 Among individuals with low plasma folate, those possessing 2 copies of MTHFR mutant alleles had significantly higher homocysteine concentrations than did those with > or = 1 copy of the wild-type allele. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 71-76 11170082-3 2001 Because of MTHFR"s involvement in the metabolism of folate, we investigated 64 CL/P patients and their parents for C677T MTHFR mutation. Folic Acid 52-58 methylenetetrahydrofolate reductase Homo sapiens 11-16 12083967-1 2001 5,10-Methylenetetrahydrofolate reductase (MTHFR) plays a key role in folate metabolism by channeling one-carbon units between nucleotide synthesis and methylation reactions. Folic Acid 24-30 methylenetetrahydrofolate reductase Homo sapiens 42-47 12083967-8 2001 Colonic cancer and acute leukemia, however, appear to be less frequent in individuals homozygous for the 677T polymorphism.MTHFR polymorphisms influence the homocysteine-lowering effect of folates and could modify the pharmacodynamics of antifolates and many other drugs whose metabolism, biochemical effects, or target structures require methylation reactions. Folic Acid 189-196 methylenetetrahydrofolate reductase Homo sapiens 123-128 11299748-2 2001 Methylenetetrahydrofolate reductase (MTHFR) plays a role in the metabolism of folate. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 11299748-4 2001 We analyzed the association between MTHFR genotype and the folate pool in gastrointestinal cancer tissues. Folic Acid 59-65 methylenetetrahydrofolate reductase Homo sapiens 36-41 11299748-16 2001 These results suggest a link between MTHFR genotype and the folate pool in gastrointestinal cancer, leading to the association of MTHFR genotype with TS inhibition rate upon 5-FU exposure. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 37-42 11299748-16 2001 These results suggest a link between MTHFR genotype and the folate pool in gastrointestinal cancer, leading to the association of MTHFR genotype with TS inhibition rate upon 5-FU exposure. Folic Acid 60-66 methylenetetrahydrofolate reductase Homo sapiens 130-135 11205486-9 2001 These findings have been bolstered by an association between incidence of colon cancer and a polymorphism in the gene for methylenetetrahydrofolate reductase, an enzyme involved in folic acid metabolism. Folic Acid 181-191 methylenetetrahydrofolate reductase Homo sapiens 122-157 12044312-5 2001 Patients who were found to be homozygotes for the methylenetetrahydrofolate reductase mutation also received folic acid supplementation throughout their pregnancy. Folic Acid 109-119 methylenetetrahydrofolate reductase Homo sapiens 50-85 11523237-8 2001 A strong inverse correlation was found between folate or vitamin B12 and plasma Hcy levels according to MTHFR genotype (P < 0.01). Folic Acid 47-53 methylenetetrahydrofolate reductase Homo sapiens 104-109 11468972-1 2001 Methylenetetrahydrofolate reductase (MTHFR), is a cytosolic enzyme, the product of which is N5-metyltetrahydrofolate, the main form of folates in tissues and the carbon donor for methylation of homocysteine to methionine. Folic Acid 135-142 methylenetetrahydrofolate reductase Homo sapiens 0-35 11468972-1 2001 Methylenetetrahydrofolate reductase (MTHFR), is a cytosolic enzyme, the product of which is N5-metyltetrahydrofolate, the main form of folates in tissues and the carbon donor for methylation of homocysteine to methionine. Folic Acid 135-142 methylenetetrahydrofolate reductase Homo sapiens 37-42 11464627-3 2001 Methylenetetrahydrofolate reductase enzyme (MTHFR) plays an important role in folate metabolism. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 44-49 11204578-0 2001 Relationships between homocysteine, folate and vitamin B12 levels with the methylenetetrahydrofolate reductase polymorphism, in Indians from Western Venezuela. Folic Acid 36-42 methylenetetrahydrofolate reductase Homo sapiens 75-110 11177206-2 2000 The aim of the present study was to determine the impact of this MTHFR common mutation on plasma and erythrocyte folate (RCF) and plasma total homocysteine (tHcy) concentrations in healthy French adults. Folic Acid 113-119 methylenetetrahydrofolate reductase Homo sapiens 65-70 11098041-2 2000 The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 58-93 11098041-2 2000 The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. Folic Acid 32-38 methylenetetrahydrofolate reductase Homo sapiens 95-100 11098041-2 2000 The most common inborn error of folate metabolism is mild methylenetetrahydrofolate reductase (MTHFR) deficiency due to the synthesis of a thermolabile variant of the enzyme with impaired catalytic activity which leads to reduced 5-methyltetrahydrofolate (5-methyl-THF) and mildly elevated homocysteine plasma concentrations when folate status is inadequate. Folic Acid 77-83 methylenetetrahydrofolate reductase Homo sapiens 95-100 11092508-1 2000 Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. Folic Acid 58-64 methylenetetrahydrofolate reductase Homo sapiens 76-81 11092508-1 2000 Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 39-74 11092508-1 2000 Individuals who are homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C --> T mutation have depressed serum folate (SF) and elevated plasma total homocysteine (tHcy) concentrations, which may affect folate requirements and increase the risk for coronary artery disease. Folic Acid 127-133 methylenetetrahydrofolate reductase Homo sapiens 76-81 11092508-8 2000 These data suggest that older women who are homozygous for the MTHFR 677C --> T mutation may be at risk for greater elevations in plasma tHcy in response to moderately low folate intake as compared with individuals with the normal or heterozygous genotypes. Folic Acid 175-181 methylenetetrahydrofolate reductase Homo sapiens 63-68 11080594-1 2000 Methylenetetrahydrofolate reductase (MTHFR), a pivotal enzyme in folate metabolism, regulates the proportional distribution of one-carbon moieties between cellular methylation reactions and nucleic acid synthesis. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 11048629-1 2000 To evaluate the relationship between genotypes of methylene tetrahydrofolate reductase (MTHFR), and plasma folate and homocysteine (Hcy) levels in meningomyelocele, 21 Korean patients, 47 of their family members, and 43 healthy controls were recruited. Folic Acid 70-76 methylenetetrahydrofolate reductase Homo sapiens 88-93 10980581-1 2000 The human 5,10-methylenetetrahydrofolate reductase (MTHFR) represents a major enzyme in the folate-dependent regulation of methionine and homocysteine concentrations. Folic Acid 34-40 methylenetetrahydrofolate reductase Homo sapiens 52-57 10986435-7 2000 Thus, a dysfunctional MTHFR partly explains the observed elevated Hcy levels in women with NTD pregnancies, and also in part the protective effect of folate on NTD. Folic Acid 150-156 methylenetetrahydrofolate reductase Homo sapiens 22-27 10952104-9 2000 These data are consistent with prior observations, which suggest that the T/T genotype is associated with impaired MTHFR activity in vivo and that the cellular impact of this impairment is determined, in part, by folate status. Folic Acid 213-219 methylenetetrahydrofolate reductase Homo sapiens 115-120 10894832-2 2000 The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 102-137 10894832-2 2000 The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 139-144 10820175-10 2000 After completion of the 4-wk treatment period with 30 or 60 mg of folic acid per day, there was a marked rebound of total homocysteine plasma levels at the end of the follow-up in patients with the MTHFR 677TT genotype, which even exceeded baseline values in several patients (P = 0.0001). Folic Acid 66-76 methylenetetrahydrofolate reductase Homo sapiens 198-203 10791559-1 2000 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 53-58 10720211-1 2000 Methylenetetrahydrofolate reductase (MTHFR) plays a central role in the folate cycle and contributes to the metabolism of the amino acid homocysteine. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 11860891-11 2000 Higher level of folate in the body can interfere the relationship between plasma tHcy and activity of MTHFR. Folic Acid 16-22 methylenetetrahydrofolate reductase Homo sapiens 102-107 10593891-1 1999 Methylenetetrahydrofolate reductase (MTHFR) is the least understood enzyme of folate-mediated one-carbon metabolism in plants. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 10910677-6 1999 Presence of the MTHFR 677 C-->T mutation increases the requirements for folic acid, especially at the time of rapid foetal growth. Folic Acid 75-85 methylenetetrahydrofolate reductase Homo sapiens 16-21 10505780-3 1999 Important diet-gene interactions may exist, as illustrated by differential responses to variation in folate status in those with methylenetetrahydrofolate reductase polymorphisms. Folic Acid 101-107 methylenetetrahydrofolate reductase Homo sapiens 129-164 10360632-2 1999 A common mutation (C677T) in the gene encoding for the enzyme methylenetetrahydrofolate reductase (MTHFR) has been linked to increased plasma homocysteine levels in homozygous carriers, particularly in the presence of low folate levels. Folic Acid 81-87 methylenetetrahydrofolate reductase Homo sapiens 99-104 10332959-9 1999 This work provides a new panel of genetic variants for studies of folate metabolism and supports, in some NTD populations, an association between MTHFR and NTDs. Folic Acid 66-72 methylenetetrahydrofolate reductase Homo sapiens 146-151 10027946-2 1999 The 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T has been shown to result in increased total homocysteine concentrations on the basis of low folate levels caused by a decreased enzyme activity. Folic Acid 28-34 methylenetetrahydrofolate reductase Homo sapiens 46-51 10027946-9 1999 The MTHFR C677T gene polymorphism significantly influenced total homocysteine and folate plasma concentrations in renal transplant recipients (P = 0.0009 and P = 0.0002, respectively). Folic Acid 82-88 methylenetetrahydrofolate reductase Homo sapiens 4-9 10027946-14 1999 CONCLUSIONS: This study demonstrates that homozygosity for the C677T polymorphism in the MTHFR gene significantly increases total homocysteine concentrations and lowers folate levels in kidney graft recipients, even in patients with excellent renal function (GFR more than median). Folic Acid 169-175 methylenetetrahydrofolate reductase Homo sapiens 89-94 9930566-8 1999 Inborn errors of folate metabolism are rare, but polymorphisms affecting the gene for methylenetetrahydrofolate reductase (MTHFR) are common and may have significant health implications. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 86-121 9930566-8 1999 Inborn errors of folate metabolism are rare, but polymorphisms affecting the gene for methylenetetrahydrofolate reductase (MTHFR) are common and may have significant health implications. Folic Acid 17-23 methylenetetrahydrofolate reductase Homo sapiens 123-128 9870206-6 1998 These data suggest that the 677C-T MTHFR polymorphism is not a major determinant of the vascular disease but contributes to increased plasma homocysteine concentration in conjunction with low plasma folate levels. Folic Acid 199-205 methylenetetrahydrofolate reductase Homo sapiens 35-40 9826223-4 1998 MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium. Folic Acid 40-46 methylenetetrahydrofolate reductase Homo sapiens 0-5 9826223-4 1998 MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium. Folic Acid 87-93 methylenetetrahydrofolate reductase Homo sapiens 0-5 9826223-4 1998 MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium. Folic Acid 170-180 methylenetetrahydrofolate reductase Homo sapiens 0-5 9826223-4 1998 MTHFR activity seems to be dependent on folate status, as shown by a lower activity in folate-deficient subjects and a return to normal values after supplementation with folic acid, and also by a decreased enzymatic activity on phytohemagglutinin (PHA)-stimulated lymphocytes grown in a folic acid-deficient medium. Folic Acid 287-297 methylenetetrahydrofolate reductase Homo sapiens 0-5 9687553-0 1998 Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages. Folic Acid 134-144 methylenetetrahydrofolate reductase Homo sapiens 0-35 9625844-1 1998 Methylenetetrahydrofolate reductase (MTHFR) is a critical enzyme in the folate cycle. Folic Acid 19-25 methylenetetrahydrofolate reductase Homo sapiens 37-42 9674907-0 1998 Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor. Folic Acid 10-17 methylenetetrahydrofolate reductase Homo sapiens 79-119 9674907-0 1998 Low blood folates in NTD pregnancies are only partly explained by thermolabile 5,10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor. Folic Acid 10-16 methylenetetrahydrofolate reductase Homo sapiens 79-119 9674907-1 1998 Thermolabile 5,10-methylenetetrahydrofolate reductase (MTHFR) is the first folate-related variant to be associated with an increased risk of neural tube defects (NTDs). Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 55-60 9674907-3 1998 We examined the relationship between folate status and presence of the common mutation MTHFR C677T in 82 NTD-affected and 260 control mothers. Folic Acid 37-43 methylenetetrahydrofolate reductase Homo sapiens 87-92 9674907-7 1998 This study shows that homozygosity for the C677T MTHFR variant cannot account for reduced blood folate levels in many NTD-affected mothers. Folic Acid 96-102 methylenetetrahydrofolate reductase Homo sapiens 49-54 9667396-7 1998 Folic acid acts to increase the activity of the variant methylenetetrahydrofolate reductase thereby reducing plasma homocysteine levels. Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 56-91 9545395-10 1998 These data suggest that the combined heterozygosity for the two MTHFR common mutations accounts for a proportion of folate-related NTDs, which is not explained by homozygosity for the 677(C-->T) mutation, and can be an additional genetic risk factor for NTDs. Folic Acid 116-122 methylenetetrahydrofolate reductase Homo sapiens 64-69 9550581-0 1998 Whole-blood folate values in subjects with different methylenetetrahydrofolate reductase genotypes: differences between the radioassay and microbiological assays. Folic Acid 12-18 methylenetetrahydrofolate reductase Homo sapiens 53-88 9244205-8 1997 Among control subjects, 12.7% were homozygous for the MTHFR T677 allele, and these women had higher plasma tHCY and lower plasma folate than women with other genotypes. Folic Acid 129-135 methylenetetrahydrofolate reductase Homo sapiens 54-59 9244205-11 1997 Although homozygosity for MTHFR T677 is related to increased plasma tHCY and low plasma folate, this genetic characteristic is not a risk factor for MI in this population. Folic Acid 88-94 methylenetetrahydrofolate reductase Homo sapiens 26-31 9247365-10 1997 Our study indicates that homozygosity for the 677C-->T MTHFR mutation, especially in combination with low folate status, predisposes to high plasma levels of fasting tHcy. Folic Acid 109-115 methylenetetrahydrofolate reductase Homo sapiens 58-63 9259028-6 1997 Homozygosity for thermolabile MTHFR deficiency has been identified as one important genetic factor, which expression is modified by dietary folate intake. Folic Acid 140-146 methylenetetrahydrofolate reductase Homo sapiens 30-35 9067278-16 1997 In particular, these results suggest that the 677C-->IT mutation in MTHFR reduces colon cancer risk, perhaps by increasing 5,10-methylenetetrahydrofolate levels for DNA synthesis, but that low folate intake or high alcohol consumption may negate some of the protective effect. Folic Acid 150-156 methylenetetrahydrofolate reductase Homo sapiens 71-76 9138952-2 1997 Our research team on prevention of birth defects could demonstrate that folic acid preventable NTDs are partly based on hyperhomocystinemia and a genetic predisposition (mutation of the methylenetetrahydrofolate-reductase gene (MTHF-R)). Folic Acid 72-82 methylenetetrahydrofolate reductase Homo sapiens 186-221 9138952-2 1997 Our research team on prevention of birth defects could demonstrate that folic acid preventable NTDs are partly based on hyperhomocystinemia and a genetic predisposition (mutation of the methylenetetrahydrofolate-reductase gene (MTHF-R)). Folic Acid 72-82 methylenetetrahydrofolate reductase Homo sapiens 228-235 9099956-6 1997 Although it cannot be stated that MTHFR is the target gene of the chromosomal loss involving the 1p36.3 region, a correlation between loss of heterozygosity at this locus and decrease in MTHFR activity was shown, suggesting a role of these allelic deletions in generating a biochemical defect in folate metabolism. Folic Acid 296-302 methylenetetrahydrofolate reductase Homo sapiens 187-192 8989110-8 1996 In the vascular disease subjects, despite significantly lower folate levels in MTHFR homozygotes, there was no significant difference in homocysteine levels among the MTHFR genotype groups. Folic Acid 62-68 methylenetetrahydrofolate reductase Homo sapiens 79-84 8989110-9 1996 The negative slope of the regression line relating homocysteine and folate was significantly steeper for those with a homozygous MTHFR mutation compared with those without this mutation. Folic Acid 68-74 methylenetetrahydrofolate reductase Homo sapiens 129-134 8989110-11 1996 Because MTHFR homozygotes have increased homocysteine with low folate levels, this mutation may contribute to early-onset or familial vascular disease. Folic Acid 63-69 methylenetetrahydrofolate reductase Homo sapiens 8-13 8921781-3 1996 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate, which serves as a methyl donor for remethylation of homocysteine to methionine. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 53-58 8901666-10 1996 MTHFR, which modulates basal plasma homocysteine concentration, is folate dependent, and dietary supplementation or fortification with folic acid may reduce plasma homocysteine levels and consequent coronary risk in a significant proportion of the general population. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 0-5 9303018-10 1997 CONCLUSIONS: In patients with CVD we confirmed a relationship between the MTHFR genotype and serum homocysteine concentration and an interaction with serum folate concentration. Folic Acid 156-162 methylenetetrahydrofolate reductase Homo sapiens 74-79 9194768-0 1997 The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes. Folic Acid 15-25 methylenetetrahydrofolate reductase Homo sapiens 109-144 9194768-2 1997 Folic acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5, 10-methylenetetrahydrofolate reductase (MTHFR) may contribute to variability in reduction. Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 152-190 9194768-2 1997 Folic acid (FA) supplementation usually lowers tHcy levels, but initial tHcy and vitamin levels, multivitamin use, and polymorphisms in the gene for 5, 10-methylenetetrahydrofolate reductase (MTHFR) may contribute to variability in reduction. Folic Acid 0-10 methylenetetrahydrofolate reductase Homo sapiens 192-197 9067278-2 1997 The enzyme 5,10-methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of 5,10-methylenetetrahydrofolate, required for purine and thymidine syntheses, to 5-methyltetrahydrofolate, the primary circulatory form of folate necessary for methionine synthesis. Folic Acid 35-41 methylenetetrahydrofolate reductase Homo sapiens 53-58 8994411-8 1997 CONCLUSIONS: Although it is accepted that moderate hyperhomocysteinemia significantly increases the risk for coronary, cerebrovascular, and peripheral vascular diseases, our data suggest that a mutation of the MTHFR gene, which has been associated with a thermolabile form of the enzyme and with hyperhomocysteinemia in subjects with plasma folate below the median, does not appear to be significantly associated with risk for premature coronary artery disease or for restenosis after coronary angioplasty. Folic Acid 341-347 methylenetetrahydrofolate reductase Homo sapiens 210-215 8935478-7 1996 The MTHFR thermolabile genotype should be considered when population studies are designed to determine the effective homocysteine-lowering dose of dietary folate supplements, and when prophylactic doses of folate are recommended for individuals. Folic Acid 155-161 methylenetetrahydrofolate reductase Homo sapiens 4-9 8826441-1 1996 Persons with a thermolabile form of the enzyme 5,10 methylenetetrahydrofolate reductase (MTHFR) have reduced enzyme activity and increased plasma homocysteine which can be lowered by supplemental folic acid. Folic Acid 196-206 methylenetetrahydrofolate reductase Homo sapiens 89-94 8826441-5 1996 These preliminary data suggest that the 677C-->T polymorphism of the MTHFR gene is a risk factor for spina bifida and anencephaly that may provide a partial biologic explanation for why folic acid prevents these types of NTD. Folic Acid 189-199 methylenetetrahydrofolate reductase Homo sapiens 72-77 8616944-6 1996 CONCLUSIONS: Individuals with thermolabile MTHFR may have a higher folate requirement for regulation of plasma homocysteine concentrations; folate supplementation may be necessary to prevent fasting hyperhomocysteinemia in such persons. Folic Acid 67-73 methylenetetrahydrofolate reductase Homo sapiens 43-48 7726158-2 1995 This form of folate is generated from 5,10-methylenetetrahydrofolate through the action of 5,10-methylenetetrahydrofolate reductase (MTHFR), a cytosolic flavoprotein. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 91-131 7726158-2 1995 This form of folate is generated from 5,10-methylenetetrahydrofolate through the action of 5,10-methylenetetrahydrofolate reductase (MTHFR), a cytosolic flavoprotein. Folic Acid 13-19 methylenetetrahydrofolate reductase Homo sapiens 133-138 7647779-3 1995 5, 10-Methylenetetrahydrofolate reductase (MTHFR) catalyzes the reduction of 5, 10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the predominant circulatory form of folate and carbon donor for the re-methylation of homocysteine to methionine. Folic Acid 25-31 methylenetetrahydrofolate reductase Homo sapiens 43-48 7993656-10 1994 Based on our hypothesis that an NTD lesion exists upstream from MTHFR, we expound how pteroylmonoglutamate supplementation may protect against NTD (i) by reducing endotoxic homocysteine and (ii) through inhibiting MTHFR (as do dihydrofolates) and thus diverting one carbon units into DNA thymine. Folic Acid 86-106 methylenetetrahydrofolate reductase Homo sapiens 64-69 7993656-10 1994 Based on our hypothesis that an NTD lesion exists upstream from MTHFR, we expound how pteroylmonoglutamate supplementation may protect against NTD (i) by reducing endotoxic homocysteine and (ii) through inhibiting MTHFR (as do dihydrofolates) and thus diverting one carbon units into DNA thymine. Folic Acid 86-106 methylenetetrahydrofolate reductase Homo sapiens 214-219