PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1705463-2 1991 Alterations in CSF amine metabolite levels were related primarily to PHT intoxication, and low CSF folate and thiamine levels, but not to length of treatment or CNS atrophy. Folic Acid 99-105 colony stimulating factor 2 Homo sapiens 15-18 1705463-2 1991 Alterations in CSF amine metabolite levels were related primarily to PHT intoxication, and low CSF folate and thiamine levels, but not to length of treatment or CNS atrophy. Folic Acid 99-105 colony stimulating factor 2 Homo sapiens 95-98 1705463-4 1991 Low folate levels were associated with decreased CSF 5HIAA and homovanillic acid, while low thiamine levels were associated with decreased CSF 5HIAA and 3-methyoxy-4-hydroxyphenylethylene glycol. Folic Acid 4-10 colony stimulating factor 2 Homo sapiens 49-52 3907060-4 1985 Altogether seven patients had low folate levels in both serum and CSF. Folic Acid 34-40 colony stimulating factor 2 Homo sapiens 66-69 3907060-5 1985 After being treated in the hospital for one week, both serum and CSF folate levels increased in nine convalescent subjects. Folic Acid 69-75 colony stimulating factor 2 Homo sapiens 65-68 3907060-6 1985 The CSF folate levels were statistically significantly higher than those of the acute malarial stage. Folic Acid 8-14 colony stimulating factor 2 Homo sapiens 4-7 3907060-7 1985 These findings indicated that both serum and CSF folate levels were depressed in patients with cerebral malaria and increased after recovery. Folic Acid 49-55 colony stimulating factor 2 Homo sapiens 45-48 6255104-6 1980 Folate therapy significantly reversed abnormalities in motor and sensory nerve distal latencies; the effect was greater with 5-formyltetrahydrofolate, apparently because this produced higher CSF folate concentrations than folic acid. Folic Acid 0-6 colony stimulating factor 2 Homo sapiens 191-194 6255104-6 1980 Folate therapy significantly reversed abnormalities in motor and sensory nerve distal latencies; the effect was greater with 5-formyltetrahydrofolate, apparently because this produced higher CSF folate concentrations than folic acid. Folic Acid 143-149 colony stimulating factor 2 Homo sapiens 191-194 958035-5 1976 A low folic serum acid level could induce minor neuropsychiatric symptoms while an additional low CSF folate could induce major neurological symptoms in spite of the presence of a normal erythrocyte folate level and in the absence of frank anemia. Folic Acid 102-108 colony stimulating factor 2 Homo sapiens 98-101 958035-5 1976 A low folic serum acid level could induce minor neuropsychiatric symptoms while an additional low CSF folate could induce major neurological symptoms in spite of the presence of a normal erythrocyte folate level and in the absence of frank anemia. Folic Acid 199-205 colony stimulating factor 2 Homo sapiens 98-101 30420205-2 2019 A specific transporter protein is required to transport folate from blood to CSF. Folic Acid 56-62 colony stimulating factor 2 Homo sapiens 77-80 27523499-9 2017 Cerebral folate deficiency (N=12) was most common, with normal serum folate levels and low CSF 5-methyltetrahydrofolate (5-MTHF) levels. Folic Acid 9-15 colony stimulating factor 2 Homo sapiens 91-94 25747036-5 2015 In terms of micronutrient transport, ascorbic acid, folate and other essential factors are transported by specific (cloned) carriers across CP into ventricular CSF, from which they penetrate across the ependyma and pia mater deeply into the brain to support its viability and function. Folic Acid 52-58 colony stimulating factor 2 Homo sapiens 160-163 24059870-3 2013 By focusing on four essential energy-requiring CP functions, specifically ascorbic acid (AA) and folate transport from blood into CSF, transthyretin synthesis and secretion into CSF, and electrolyte/acid-base balance in CSF, we were able to evaluate the hypothesis of CP failure by reviewing definitive human data. Folic Acid 97-103 colony stimulating factor 2 Homo sapiens 130-133 19951991-4 2009 The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization. Folic Acid 19-25 colony stimulating factor 2 Homo sapiens 111-117 15781839-1 2005 The authors describe a 6-year-old girl with developmental delay, psychomotor regression, seizures, mental retardation, and autistic features associated with low CSF levels of 5-methyltetrahydrofolate, the biologically active form of folates in CSF and blood. Folic Acid 233-240 colony stimulating factor 2 Homo sapiens 161-164 12963755-7 2003 CSF investigations in three patients with classic AGS also showed increased pterins and partially lowered folate levels. Folic Acid 106-112 colony stimulating factor 2 Homo sapiens 0-3 12963755-9 2003 Long-term substitution with folinic acid (2-4 mg/kg/day) resulted in substantial clinical recovery with normalization of CSF folates and pterins in one patient and clinical improvement in another. Folic Acid 125-132 colony stimulating factor 2 Homo sapiens 121-124 12089131-1 2002 We report on a child in whom severe nutritional vitamin B12 deficiency was exacerbated by a genetic impairment of the folate cycle, causing reduced CSF concentrations of the methyl group donor 5-methyltetrahydrofolate. Folic Acid 118-124 colony stimulating factor 2 Homo sapiens 148-151 11388596-10 2001 Low CSF folate levels (13.9 and 12.6 ng/ml, reference range 15-40 ng/ml) and an alteration in the CSF/serum folate ratio (1.43 and 1.16, normal ratio 3:1) were also found as well as increased levels of cystathionine both in CSF (40 micromol/l, reference range 18-28 micromol/l) and in serum (32 micromol/l, reference value <0.10 micromol/l). Folic Acid 8-14 colony stimulating factor 2 Homo sapiens 4-7 11261750-0 2001 CSF-folate levels are decreased in late-onset AD patients. Folic Acid 4-10 colony stimulating factor 2 Homo sapiens 0-3 11261750-2 2001 Remarkably CSF-folate levels are 3 to 4 times higher than blood-folate levels. Folic Acid 15-21 colony stimulating factor 2 Homo sapiens 11-14 11261750-3 2001 To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired. Folic Acid 20-27 colony stimulating factor 2 Homo sapiens 212-215 11261750-3 2001 To reach the brain, folates are actively transported by choroid plexus (CP) as well as vitamins B6, B12, C and E. Epithelial atrophy having been reported in aging and in Alzheimer"s disease (AD), we measured the CSF folate-levels of 126 patients, including 30 AD consecutive patients to evaluate whether CP functions of folate-transport were impaired. Folic Acid 20-26 colony stimulating factor 2 Homo sapiens 212-215 11261750-4 2001 CSF-folate concentrations did not vary with age (10.47 +/- 1.93ng/ml between 20 and 60 years; 9.96 +/- 2.01 ng/ml in elderly control patients older than 60 years of age, p > 0.05) while late-onset AD patients had significantly lower CSF-folate levels (8.26 +/- 1.82 ng/ml, p < 0.001). Folic Acid 4-10 colony stimulating factor 2 Homo sapiens 0-3 11183038-0 2000 Folate in CSF and age. Folic Acid 0-6 colony stimulating factor 2 Homo sapiens 10-13 10896698-8 2000 Depressed patients with raised total plasma homocysteine had significant lowering of serum, red cell, and CSF folate, CSF S-adenosylmethionine and all three CSF monoamine metabolites. Folic Acid 110-116 colony stimulating factor 2 Homo sapiens 106-109 9638660-15 1998 Determinations of folates and organic acids in CSF appear at present only warrantable individually in special constellations, e.g. classical clinical findings and disease course suggestive of glutaryl-CoA dehydrogenase deficiency with repeated negative quantitative analyses of organic acids in urine. Folic Acid 18-25 colony stimulating factor 2 Homo sapiens 47-50 8126512-2 1994 A severe folate deficiency state was found in CSF in combination with a normal serum and red cell folate state. Folic Acid 9-15 colony stimulating factor 2 Homo sapiens 46-49 8177846-2 1994 Twenty patients fulfilled the following criteria (a) they presented with neurological findings for which no other cause could be found (b) the serum or red cell and/or the CSF folate was low (c) the serum vitamin B12 or vitamin B12 absorption was normal and (d) they showed a significant response to folic acid. Folic Acid 176-182 colony stimulating factor 2 Homo sapiens 172-175