PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20534379-0	2010	Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects.	Folic Acid	28-38	aristaless-like homeobox 3	Mus musculus	0-4	
24639464-7	2014	Moreover, the folic-acid-dependent gene Alx3 is significantly downregulated in Lrp2 mutants.	Folic Acid	14-24	aristaless-like homeobox 3	Mus musculus	40-44	
20534379-4	2010	We report that folic acid is required in mouse embryos for the specific expression of the homeodomain gene Alx3 in the head mesenchyme, an important tissue for cranial neural tube closure.	Folic Acid	15-25	aristaless-like homeobox 3	Mus musculus	107-111	
20534379-5	2010	Alx3-deficient mice exhibit increased failure of cranial neural tube closure and increased cell death in the craniofacial region, two effects that are also observed in wild type embryos developing in the absence of folic acid.	Folic Acid	215-225	aristaless-like homeobox 3	Mus musculus	0-4	
20534379-6	2010	Folic acid cannot prevent these defects in Alx3-deficient embryos, indicating that one mechanism of folic acid action is through induced expression of Alx3.	Folic Acid	100-110	aristaless-like homeobox 3	Mus musculus	151-155