PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15122597-9 2004 Although compound homozygous variants at cSHMT and MTHFD1 loci had the lowest plasma folate levels compared to other compound genotypes, no significant gene-gene interactions were observed. Folic Acid 85-91 serine hydroxymethyltransferase 1 Homo sapiens 41-46 15170323-10 2004 These results clearly indicate that interaction of Glu75 with folate is required for folate-dependent reactions catalyzed by SHMT. Folic Acid 62-68 serine hydroxymethyltransferase 1 Homo sapiens 125-129 15170323-10 2004 These results clearly indicate that interaction of Glu75 with folate is required for folate-dependent reactions catalyzed by SHMT. Folic Acid 85-91 serine hydroxymethyltransferase 1 Homo sapiens 125-129 11516159-1 2001 The role of cytosolic and mitochondrial serine hydroxymethyltransferase in supplying one-carbon groups for purine and thymidylate biosynthesis in MCF-7 cells was investigated by observing folate-mediated one-carbon metabolism of l-[3-(13)C]serine, [2-(13)C]glycine, and [(13)C]formate. Folic Acid 188-194 serine hydroxymethyltransferase 1 Homo sapiens 12-71 12161434-0 2002 Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. Folic Acid 73-79 serine hydroxymethyltransferase 1 Homo sapiens 0-43 12138190-5 2002 SHMT enzymes are the major source of the one-carbon unit required for folate metabolism and for the biosynthesis of nucleotides and amino acids. Folic Acid 70-76 serine hydroxymethyltransferase 1 Homo sapiens 0-4 11386852-6 2001 Theoretically, mutated SHMT could lead to elevated Hcy levels and to an altered distribution of the different folate derivatives and might therefore become a risk factor for NTD. Folic Acid 110-116 serine hydroxymethyltransferase 1 Homo sapiens 23-27 11386852-16 2001 Still, the influence of the 1420 C>T polymorphism of the cSHMT gene on the folate-related risk of NTD needs further investigation. Folic Acid 78-84 serine hydroxymethyltransferase 1 Homo sapiens 60-65 11305908-3 2001 Cytoplasmic SHMT (cSHMT) has been postulated to channel one-carbon substituted folates to various folate-dependent enzymes, and alternative splicing of the cSHMT transcript may be a mechanism that enables specific protein-protein interactions. Folic Acid 79-86 serine hydroxymethyltransferase 1 Homo sapiens 18-23 11305908-3 2001 Cytoplasmic SHMT (cSHMT) has been postulated to channel one-carbon substituted folates to various folate-dependent enzymes, and alternative splicing of the cSHMT transcript may be a mechanism that enables specific protein-protein interactions. Folic Acid 79-85 serine hydroxymethyltransferase 1 Homo sapiens 18-23 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). Folic Acid 67-73 serine hydroxymethyltransferase 1 Homo sapiens 312-343 7520695-1 1994 The aim of the present work was to further determine how the T-protein of the glycine-cleavage system and serine hydroxy-methyltransferase (SHMT), two folate-dependent enzymes from pea leaf mitochondria, interact through a common pool of tetrahydrofolate polyglutamates (H4PteGlun). Folic Acid 151-157 serine hydroxymethyltransferase 1 Homo sapiens 106-138 7520695-1 1994 The aim of the present work was to further determine how the T-protein of the glycine-cleavage system and serine hydroxy-methyltransferase (SHMT), two folate-dependent enzymes from pea leaf mitochondria, interact through a common pool of tetrahydrofolate polyglutamates (H4PteGlun). Folic Acid 151-157 serine hydroxymethyltransferase 1 Homo sapiens 140-144 35098008-5 2021 The polymorphic loci of folate cycle genes including rs1805087 5-methylenetetrahydrofolate (MTR) and rs1979277 serine hydroxymethyl transferase (SHMT1) were examined. Folic Acid 24-30 serine hydroxymethyltransferase 1 Homo sapiens 145-150 32142918-8 2020 Similar to its family member SHMT2, SHMT1 plays a crucial role in folate-dependent serine/glycine inter-conversion in one-carbon metabolism. Folic Acid 66-72 serine hydroxymethyltransferase 1 Homo sapiens 36-41 31713293-1 2020 OBJECTIVE: To assess the association between polymorphic variants from SHMT1 and MTHFS genes, involved in the cytoplasmic futile folate cycle, and the risk of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in the Chilean population. Folic Acid 129-135 serine hydroxymethyltransferase 1 Homo sapiens 71-76 31713293-5 2020 CONCLUSIONS: Owing to the rs1979277 A allele, which reduces the cytoplasmic SHMT activity and has a higher frequency in controls than in NSCL/P cases, we hypothesized that a low enzyme activity may increase the cytoplasmic concentration of folates and, therefore, explain the protective role against OFCs. Folic Acid 240-247 serine hydroxymethyltransferase 1 Homo sapiens 76-80 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). Folic Acid 3-9 serine hydroxymethyltransferase 1 Homo sapiens 312-343 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). Folic Acid 3-9 serine hydroxymethyltransferase 1 Homo sapiens 345-349 10766749-8 2000 The effect of mimosine on folate metabolism is associated with decreased cytoplasmic serine hydroxymethyltransferase (cSHMT) expression in MCF-7 cells but not in SH-SY5Y cells. Folic Acid 26-32 serine hydroxymethyltransferase 1 Homo sapiens 73-116 10766749-8 2000 The effect of mimosine on folate metabolism is associated with decreased cytoplasmic serine hydroxymethyltransferase (cSHMT) expression in MCF-7 cells but not in SH-SY5Y cells. Folic Acid 26-32 serine hydroxymethyltransferase 1 Homo sapiens 118-123 8533763-1 1995 Folate-dependent one-carbon metabolism is critical for the synthesis of numerous cellular constituents required for cell growth, and serine hydroxymethyltransferase (SHMT) is central to this process. Folic Acid 0-6 serine hydroxymethyltransferase 1 Homo sapiens 166-170 33326752-3 2021 Here, we show that under physiological folate levels in the cell environment, cytosolic serine-hydroxymethyltransferase (SHMT1) is the predominant source of 1C units in a variety of cancers, while mitochondrial 1C flux is overly repressed. Folic Acid 39-45 serine hydroxymethyltransferase 1 Homo sapiens 78-119 33326752-3 2021 Here, we show that under physiological folate levels in the cell environment, cytosolic serine-hydroxymethyltransferase (SHMT1) is the predominant source of 1C units in a variety of cancers, while mitochondrial 1C flux is overly repressed. Folic Acid 39-45 serine hydroxymethyltransferase 1 Homo sapiens 121-126 30411815-1 2019 BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is an enzyme involved in folic acid metabolism and is known to contribute to the development of hypertension. Folic Acid 79-89 serine hydroxymethyltransferase 1 Homo sapiens 12-45 30411815-1 2019 BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is an enzyme involved in folic acid metabolism and is known to contribute to the development of hypertension. Folic Acid 79-89 serine hydroxymethyltransferase 1 Homo sapiens 47-52 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). Folic Acid 67-73 serine hydroxymethyltransferase 1 Homo sapiens 345-349 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). Folic Acid 67-73 serine hydroxymethyltransferase 1 Homo sapiens 312-343 30867454-1 2019 In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (AICARFT) and serine hydroxymethyltransferase (SHMT). Folic Acid 67-73 serine hydroxymethyltransferase 1 Homo sapiens 345-349 29474406-10 2018 Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT). Folic Acid 91-97 serine hydroxymethyltransferase 1 Homo sapiens 185-219 30500180-5 2018 On the other hand, a detailed comparison of their catalytic and regulatory properties is missing, although this aspect seems to be considerably important, considering that SHMT1 and SHMT2 reside in different cellular compartments, where they play distinct roles in folate metabolism. Folic Acid 265-271 serine hydroxymethyltransferase 1 Homo sapiens 172-177 29953918-2 2018 Some loci and genes that are associated with folate levels had been detected by genome-wide association studies (GWAS), such as rs1801133 in MTHFR and rs1979277 in SHMT1. Folic Acid 45-51 serine hydroxymethyltransferase 1 Homo sapiens 164-169 30198140-6 2018 Three folate genes (C677T-MTHFR, C1420T-SHMT, and 2R > 3R-TS) strengthen this effect in spring, and another (T401C-MTHFD) in summer. Folic Acid 6-12 serine hydroxymethyltransferase 1 Homo sapiens 40-44 29474406-10 2018 Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT). Folic Acid 91-97 serine hydroxymethyltransferase 1 Homo sapiens 221-226 26950450-1 2016 The enzymes serine hydroxymethyltransferase 1 (SHMT1) regulate key reaction in folate-mediated one-carbon metabolism. Folic Acid 79-85 serine hydroxymethyltransferase 1 Homo sapiens 12-45 27386562-7 2016 SHMT1 encodes a serine hydroxymethyltransferase catalyzing the transfer of a carbon unit to the folate cycle. Folic Acid 96-102 serine hydroxymethyltransferase 1 Homo sapiens 0-5 30378389-0 2018 The folic acid metabolism gene mel-32/Shmt is required for normal cell cycle lengths in Caenorhabditis elegans. Folic Acid 4-14 serine hydroxymethyltransferase 1 Homo sapiens 38-42 30378389-5 2018 mel-32 is an essential folic acid metabolism gene in C. elegans and a homolog to the mammalian enzyme serine hydroxymethyltransferase (Shmt). Folic Acid 23-33 serine hydroxymethyltransferase 1 Homo sapiens 135-139 26950450-1 2016 The enzymes serine hydroxymethyltransferase 1 (SHMT1) regulate key reaction in folate-mediated one-carbon metabolism. Folic Acid 79-85 serine hydroxymethyltransferase 1 Homo sapiens 47-52 26666829-1 2015 BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. Folic Acid 77-83 serine hydroxymethyltransferase 1 Homo sapiens 12-45 26666829-1 2015 BACKGROUND: Serine hydroxymethyltransferase 1 (SHMT1) is a key enzyme in the folate metabolic pathway that plays an important role in biosynthesis by providing one carbon unit. Folic Acid 77-83 serine hydroxymethyltransferase 1 Homo sapiens 47-52 24362509-0 2014 DNMT3B C46359T and SHMT1 C1420T polymorphisms in the folate pathway in carcinogenesis of head and neck. Folic Acid 53-59 serine hydroxymethyltransferase 1 Homo sapiens 19-24 25677305-3 2015 In this study, 13 folate analogues under clinical evaluation or in therapeutic use were in silico screened against SHMT, ultimately identifying four antifolate agents worthy of closer evaluation. Folic Acid 18-24 serine hydroxymethyltransferase 1 Homo sapiens 115-119 25066213-5 2014 Although no other associations were significant after multiple testing correction, variants in SHMT1 in 1-C transfer, previously reported with OC, suggested lower risk at higher folate (p(interaction) = 0.03-0.006). Folic Acid 178-184 serine hydroxymethyltransferase 1 Homo sapiens 95-100 25066213-7 2014 SHMT1 SNP-by-folate interactions are plausible but require further validation. Folic Acid 13-19 serine hydroxymethyltransferase 1 Homo sapiens 0-5 25194438-1 2014 BACKGROUND: The serine hydroxymethyltransferase (SHMT1) is the key enzyme in the folate metabolic pathway to provide one-carbon unit that plays an important role in biosynthesis. Folic Acid 81-87 serine hydroxymethyltransferase 1 Homo sapiens 49-54 24559276-3 2014 The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Folic Acid 174-180 serine hydroxymethyltransferase 1 Homo sapiens 4-34 24559276-3 2014 The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Folic Acid 174-180 serine hydroxymethyltransferase 1 Homo sapiens 36-40 25677305-2 2015 Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs. Folic Acid 124-130 serine hydroxymethyltransferase 1 Homo sapiens 0-31 25677305-2 2015 Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs. Folic Acid 124-130 serine hydroxymethyltransferase 1 Homo sapiens 33-37 25677305-2 2015 Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs. Folic Acid 160-166 serine hydroxymethyltransferase 1 Homo sapiens 0-31 25677305-2 2015 Serine hydroxymethyltransferase (SHMT), the enzyme providing one-carbon units by converting serine and tetrahydrofolate (H4 PteGlu) to glycine and 5,10-CH2 -H4 PteGlu, therefore represents a target of interest in developing new chemotherapeutic drugs. Folic Acid 160-166 serine hydroxymethyltransferase 1 Homo sapiens 33-37 24362509-3 2014 We investigated DNMT3B C46359T (rs2424913) and SHMT1 C1420T (rs1979277) polymorphisms related to folate pathway in head and neck cancer (HNC) risk and the association of the disease with gender, risk factors and clinical histopathological parameters. Folic Acid 97-103 serine hydroxymethyltransferase 1 Homo sapiens 47-52 22220685-9 2012 Finally, SHMT1 and SHMT2 expression were significantly correlated with those of other Folate and Methionine Cycle genes at both the messenger RNA and protein levels. Folic Acid 86-92 serine hydroxymethyltransferase 1 Homo sapiens 9-14 22147344-8 2013 SHMT and TYMS variants were found to decrease oxidative stress by increasing the folate pool (r = 0.38, P = 0.003) and also by increasing the antioxidant status (r = 0.28, P = 0.03). Folic Acid 81-87 serine hydroxymethyltransferase 1 Homo sapiens 0-4 23421317-0 2013 DHFR 19-bp deletion and SHMT C1420T polymorphisms and metabolite concentrations of the folate pathway in individuals with Down syndrome. Folic Acid 87-93 serine hydroxymethyltransferase 1 Homo sapiens 24-28 23421317-3 2013 AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS. Folic Acid 48-54 serine hydroxymethyltransferase 1 Homo sapiens 103-134 23421317-3 2013 AIM: Investigate the association between Dihydrofolate reductase (DHFR) 19-base pair (bp) deletion and Serine hydroxymethyltransferase (SHMT) C1420T polymorphisms and serum folate and plasma Hcy and methylmalonic acid (MMA) concentrations in 85 individuals with DS. Folic Acid 48-54 serine hydroxymethyltransferase 1 Homo sapiens 136-140 23421317-6 2013 RESULTS: Individuals with DHFR DD/SHMT TT genotypes presented increased folate concentrations (p=0.004) and the DHFR II/SHMT TT genotypes were associated with increased MMA concentrations (p=0.008). Folic Acid 72-78 serine hydroxymethyltransferase 1 Homo sapiens 34-38 23421317-8 2013 CONCLUSION: There is an association between DHFR DD/SHMT TT and DHFR II/SHMT TT combined genotypes and folate and MMA concentrations in individuals with DS. Folic Acid 103-109 serine hydroxymethyltransferase 1 Homo sapiens 52-56 23421317-8 2013 CONCLUSION: There is an association between DHFR DD/SHMT TT and DHFR II/SHMT TT combined genotypes and folate and MMA concentrations in individuals with DS. Folic Acid 103-109 serine hydroxymethyltransferase 1 Homo sapiens 72-76 21687976-4 2012 In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid). Folic Acid 180-186 serine hydroxymethyltransferase 1 Homo sapiens 71-102 21687976-4 2012 In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid). Folic Acid 180-186 serine hydroxymethyltransferase 1 Homo sapiens 104-108 21687976-4 2012 In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid). Folic Acid 202-208 serine hydroxymethyltransferase 1 Homo sapiens 71-102 21687976-4 2012 In this study, we analyzed the influence of the polymorphism C1420T in Serine hydroxymethyltransferase (SHMT) gene on maternal risk for DS and on metabolites concentrations of the folate pathway (serum folate and plasma homocysteine and methylmalonic acid). Folic Acid 202-208 serine hydroxymethyltransferase 1 Homo sapiens 104-108 21178087-1 2011 The enzymes serine hydroxymethyltransferase 1 (gene name SHMT1) and methylenetetrahydrofolate reductase (gene name MTHFR) regulate key reactions in folate-mediated one-carbon metabolism. Folic Acid 87-93 serine hydroxymethyltransferase 1 Homo sapiens 57-62 21371789-5 2011 In this study, the interaction mode of SHMT with pemetrexed, an antifolate drug inhibiting several enzymes involved in folate-dependent biosynthetic pathways, was assessed. Folic Acid 68-74 serine hydroxymethyltransferase 1 Homo sapiens 39-43 20386493-4 2010 RESULTS: RBC folate concentrations were significantly associated with MTHFR 677C>T (P=0.002), MTRR 66A>G (P<0.0001), MTHFD1 1958G>A (P=0.001) and SHMT 1420C>T (P=0.012), whereas no association of these polymorphisms with disease activity was observed. Folic Acid 13-19 serine hydroxymethyltransferase 1 Homo sapiens 158-162 18067453-5 2007 Previously, we demonstrated that cSHMT-derived folate activated one-carbon units are preferentially incorporated into thymidylate, and we provided evidence that this was achieved through modification with small ubiquitin-like modifier (SUMO) enabling SUMO-dependent nuclear localization of cSHMT during S-phase. Folic Acid 47-53 serine hydroxymethyltransferase 1 Homo sapiens 33-38 17702748-1 2007 Cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme levels are elevated by the expression of the heavy chain ferritin (H ferritin) cDNA in cultured cells without corresponding changes in mRNA levels, resulting in enhanced folate-dependent de novo thymidylate biosynthesis and impaired homocysteine remethylation. Folic Acid 229-235 serine hydroxymethyltransferase 1 Homo sapiens 0-43 17702748-1 2007 Cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme levels are elevated by the expression of the heavy chain ferritin (H ferritin) cDNA in cultured cells without corresponding changes in mRNA levels, resulting in enhanced folate-dependent de novo thymidylate biosynthesis and impaired homocysteine remethylation. Folic Acid 229-235 serine hydroxymethyltransferase 1 Homo sapiens 45-50 17420066-1 2007 Suboptimal DNA repair capacity is a risk factor for cancer that may be modulated by dietary nutrient intake, and serine hydroxymethyltransferase (SHMT) participates in folate metabolism and synthesis of purines and pyrimidines needed for DNA repair. Folic Acid 168-174 serine hydroxymethyltransferase 1 Homo sapiens 146-150 17446168-7 2007 The three folate-dependent enzymes that constitute the de novo thymidylate biosynthesis pathway, cSHMT, thymidylate synthase, and dihydrofolate reductase, all contain SUMO modification consensus sequences. Folic Acid 10-16 serine hydroxymethyltransferase 1 Homo sapiens 97-102 17446168-8 2007 Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism. Folic Acid 24-30 serine hydroxymethyltransferase 1 Homo sapiens 143-148 17446168-8 2007 Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism. Folic Acid 24-30 serine hydroxymethyltransferase 1 Homo sapiens 298-303 17446168-8 2007 Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism. Folic Acid 157-163 serine hydroxymethyltransferase 1 Homo sapiens 143-148 17446168-8 2007 Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism. Folic Acid 157-163 serine hydroxymethyltransferase 1 Homo sapiens 298-303 17446168-8 2007 Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism. Folic Acid 157-163 serine hydroxymethyltransferase 1 Homo sapiens 143-148 17446168-8 2007 Compartmentation of the folate-dependent de novo thymidylate biosynthesis pathway in the nucleus accounts for the preferential partitioning of cSHMT-derived folate-activated one-carbon units into thymidylate biosynthesis; the efficiency of nuclear folate metabolism is likely to be modified by the cSHMT L474F polymorphism. Folic Acid 157-163 serine hydroxymethyltransferase 1 Homo sapiens 298-303 19707223-2 2010 Cytoplasmic serine hydroxymethyltransferase (cSHMT) affects the flow of one-carbon units through the folate metabolic network, but there is little research on a role for genetic variation in cSHMT in determining breast cancer risk. Folic Acid 101-107 serine hydroxymethyltransferase 1 Homo sapiens 0-43 19707223-2 2010 Cytoplasmic serine hydroxymethyltransferase (cSHMT) affects the flow of one-carbon units through the folate metabolic network, but there is little research on a role for genetic variation in cSHMT in determining breast cancer risk. Folic Acid 101-107 serine hydroxymethyltransferase 1 Homo sapiens 45-50 19734144-5 2009 The UV-induced increase in SHMT1 translation is accompanied by an increase in the small ubiquitin-like modifier-dependent nuclear localization of the de novo thymidylate biosynthesis pathway and a decrease in DNA strand breaks, indicating a role for SHMT1 and nuclear folate metabolism in DNA repair. Folic Acid 268-274 serine hydroxymethyltransferase 1 Homo sapiens 27-32 17896178-1 2008 Cytosolic serine hydroxymethyltransferase (cSHMT) is key to intersection of folate-metabolic pathway, participating in the pyrimidine synthesis for DNA repair. Folic Acid 76-82 serine hydroxymethyltransferase 1 Homo sapiens 0-41 17896178-1 2008 Cytosolic serine hydroxymethyltransferase (cSHMT) is key to intersection of folate-metabolic pathway, participating in the pyrimidine synthesis for DNA repair. Folic Acid 76-82 serine hydroxymethyltransferase 1 Homo sapiens 43-48 17482557-1 2007 Folate-activated one-carbon units are derived from serine through the activity of the pyridoxal-phosphate (PLP)-dependent isozymes of serine hydroxymethyltransferase (SHMT). Folic Acid 0-6 serine hydroxymethyltransferase 1 Homo sapiens 134-165 17482557-1 2007 Folate-activated one-carbon units are derived from serine through the activity of the pyridoxal-phosphate (PLP)-dependent isozymes of serine hydroxymethyltransferase (SHMT). Folic Acid 0-6 serine hydroxymethyltransferase 1 Homo sapiens 167-171 17074544-4 2006 In black women, there appeared to be an interaction between dietary folate intake and the SHMT1(1420)T variant allele, such that only carriers who also were in the lowest quartile of dietary folate intake had higher risk of spontaneous preterm birth (OR = 2.6, 95% CI 0.8-8.0) and SGA (OR = 2.9, 95% CI 0.9-8.9). Folic Acid 68-74 serine hydroxymethyltransferase 1 Homo sapiens 90-95 17074544-4 2006 In black women, there appeared to be an interaction between dietary folate intake and the SHMT1(1420)T variant allele, such that only carriers who also were in the lowest quartile of dietary folate intake had higher risk of spontaneous preterm birth (OR = 2.6, 95% CI 0.8-8.0) and SGA (OR = 2.9, 95% CI 0.9-8.9). Folic Acid 191-197 serine hydroxymethyltransferase 1 Homo sapiens 90-95 18067453-5 2007 Previously, we demonstrated that cSHMT-derived folate activated one-carbon units are preferentially incorporated into thymidylate, and we provided evidence that this was achieved through modification with small ubiquitin-like modifier (SUMO) enabling SUMO-dependent nuclear localization of cSHMT during S-phase. Folic Acid 47-53 serine hydroxymethyltransferase 1 Homo sapiens 290-295 16006999-2 2005 We hypothesized that polymorphisms of the cytosolic serine hydroxymethyltransferase (SHMT1) gene involved in folate-dependent, one-carbon metabolism are associated with SCCHN risk. Folic Acid 109-115 serine hydroxymethyltransferase 1 Homo sapiens 42-83 16536979-1 2006 BACKGROUND & OBJECTIVE: Serine hydroxymethyltransferase (SHMT), a key enzyme in the folate metabolism, affects gene methylation and DNA synthesis through providing one-carbon units for purine, thymidylate, and methionine. Folic Acid 88-94 serine hydroxymethyltransferase 1 Homo sapiens 28-59 16536979-1 2006 BACKGROUND & OBJECTIVE: Serine hydroxymethyltransferase (SHMT), a key enzyme in the folate metabolism, affects gene methylation and DNA synthesis through providing one-carbon units for purine, thymidylate, and methionine. Folic Acid 88-94 serine hydroxymethyltransferase 1 Homo sapiens 61-65 16046727-2 2005 The cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme is proposed to regulate a key metabolic intersection in folate metabolism. Folic Acid 119-125 serine hydroxymethyltransferase 1 Homo sapiens 4-47 16046727-2 2005 The cytoplasmic serine hydroxymethyltransferase (cSHMT) enzyme is proposed to regulate a key metabolic intersection in folate metabolism. Folic Acid 119-125 serine hydroxymethyltransferase 1 Homo sapiens 49-54 16006999-2 2005 We hypothesized that polymorphisms of the cytosolic serine hydroxymethyltransferase (SHMT1) gene involved in folate-dependent, one-carbon metabolism are associated with SCCHN risk. Folic Acid 109-115 serine hydroxymethyltransferase 1 Homo sapiens 85-90 15531579-10 2005 Furthermore, this study establishes that SHMT1 is a zinc-inducible gene, which provides the first mechanism for the regulation of folate-mediated one-carbon metabolism by zinc. Folic Acid 130-136 serine hydroxymethyltransferase 1 Homo sapiens 41-46