PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22855837-3 2012 By conjugating the ligand folate with a fluorescent contrast agent, fluorescein isothiocyanate (FITC), we aimed to explore the potential role of FR-beta fluorescence imaging in the distinction of vulnerable sites from more stable regions. Folic Acid 26-32 folate receptor beta Homo sapiens 145-152 22814109-1 2012 High affinity folate binding protein (FBP) regulates as a soluble protein and as a cellular receptor intracellular trafficking of folic acid, a vitamin of great importance to cell growth and division. Folic Acid 130-140 folate receptor beta Homo sapiens 38-41 23819524-3 2013 Because folate binds with high affinity to FR-beta, development of folate directed imaging agents has proceeded rapidly in the past decade. Folic Acid 8-14 folate receptor beta Homo sapiens 43-50 23819524-3 2013 Because folate binds with high affinity to FR-beta, development of folate directed imaging agents has proceeded rapidly in the past decade. Folic Acid 67-73 folate receptor beta Homo sapiens 43-50 23506878-6 2013 Two folate receptors (FOLR1 and FOLR2) mediate folate transport across epithelia by an endocytic process. Folic Acid 4-10 folate receptor beta Homo sapiens 32-37 22855837-11 2012 These characteristics of vulnerability imply that molecular imaging of FR-beta through folate conjugates might be a good indicator for plaque vulnerability in future noninvasive imaging studies. Folic Acid 87-93 folate receptor beta Homo sapiens 71-78 19116913-0 2009 Folate receptor beta as a potential delivery route for novel folate antagonists to macrophages in the synovial tissue of rheumatoid arthritis patients. Folic Acid 61-67 folate receptor beta Homo sapiens 0-20 22211358-7 2012 FR-beta(high) macrophages from OA synovial tissues represented the majority of folic acid-binding cells. Folic Acid 79-89 folate receptor beta Homo sapiens 0-7 19116913-10 2009 CONCLUSION: Abundant FRbeta expression on activated macrophages in synovial tissue from RA patients deserves further exploration for selective therapeutic interventions with high-affinity-binding folate antagonists, of which BCG 945 may be a prototypical representative. Folic Acid 196-202 folate receptor beta Homo sapiens 21-27 19951991-3 2009 We report that folate receptor beta (FRbeta), encoded by the FOLR2 gene, is a marker for macrophages generated in the presence of M-CSF (M2), but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability. Folic Acid 15-21 folate receptor beta Homo sapiens 37-43 19951991-3 2009 We report that folate receptor beta (FRbeta), encoded by the FOLR2 gene, is a marker for macrophages generated in the presence of M-CSF (M2), but not GM-CSF (M1), and whose expression correlates with increased folate uptake ability. Folic Acid 15-21 folate receptor beta Homo sapiens 61-66 19951991-4 2009 The acquisition of folate uptake ability by macrophages is promoted by M-CSF, maintained by IL-4, prevented by GM-CSF, and reduced by IFNgamma, indicating a link between FRbeta expression and M2 polarization. Folic Acid 19-25 folate receptor beta Homo sapiens 170-176 19951991-6 2009 FRbeta is expressed, and mediates folate uptake, by CD163(+) CD68(+) CD14(+) IL-10-producing TAM, and its expression is induced by tumor-derived ascitic fluid and conditioned medium from fibroblasts and tumor cell lines in an M-CSF-dependent manner. Folic Acid 34-40 folate receptor beta Homo sapiens 0-6 19951991-7 2009 These results establish FRbeta as a marker for M2 regulatory macrophage polarization and indicate that folate conjugates of therapeutic drugs are a potential immunotherapy tool to target TAM. Folic Acid 103-109 folate receptor beta Homo sapiens 24-30 19116913-4 2009 Binding affinities of FRbeta for folate antagonists were assessed by competition experiments for 3H-folic acid binding on FRbeta-transfected cells. Folic Acid 33-39 folate receptor beta Homo sapiens 22-28 19116913-5 2009 Efficacy of FRbeta-mediated internalization of folate antagonists was evaluated by assessment of antiproliferative effects against FRbeta-transfected cells. Folic Acid 47-53 folate receptor beta Homo sapiens 12-18 19116913-5 2009 Efficacy of FRbeta-mediated internalization of folate antagonists was evaluated by assessment of antiproliferative effects against FRbeta-transfected cells. Folic Acid 47-53 folate receptor beta Homo sapiens 131-137 19116913-8 2009 Screening of 10 new-generation folate antagonists revealed 4 compounds for which FRbeta had a high binding affinity (20-77-fold higher than for MTX). Folic Acid 31-37 folate receptor beta Homo sapiens 81-87 12839949-2 2003 The nonpolyglutamatable folate-based thymidylate synthase (TS) inhibitor, CB300638 (TS K(i) = 0.24 nM) displayed an IC(50) of 0.0028 microM for the inhibition of the growth of human A431-FBP cells transfected with the alpha-FR. Folic Acid 24-30 folate receptor beta Homo sapiens 187-190 12202950-5 2002 Quantitative affinity purification of detergent-insoluble complexes using biotinylated folate or specific antibodies demonstrated a strong association of the homologous FR-alpha and FR-beta in the same detergent-insoluble complex and separate complexes containing either PLAP or caveolin. Folic Acid 87-93 folate receptor beta Homo sapiens 182-189 12831362-4 2003 An apparent post-transcriptional modification prevents FR-beta in normal haematopoietic cells from binding folate, in contrast to AML cells. Folic Acid 107-113 folate receptor beta Homo sapiens 55-62 12091353-4 2002 The posttranslational modification causing its nonfunctionality was evidently absent in FR-beta from AML cells from patient marrow, which bound folate. Folic Acid 144-150 folate receptor beta Homo sapiens 88-95 9099956-1 1997 The high-affinity folate-binding protein (FBP) is primarily involved in the uptake of the 5-methyltetrahydrofolate, and its expression may be physiologically regulated by the intracellular folate content. Folic Acid 18-24 folate receptor beta Homo sapiens 42-45 10446858-8 1999 Furthermore, the FR-beta protein was shown to have folic acid binding capacity. Folic Acid 51-61 folate receptor beta Homo sapiens 17-24 9166787-5 1997 Substitution of the amino-terminal portion (residues 1-92) in the mature FR-alpha polypeptide with the corresponding segment of FR-beta resulted in folate binding characteristics similar to FR-beta. Folic Acid 148-154 folate receptor beta Homo sapiens 128-135 9166787-7 1997 In this fashion, it was determined that the alanine residue at position 49 in FR-alpha was critical for its functional divergence from FR-beta, since substitution at this position with Leu (the corresponding residue in FR-beta) resulted in the folate binding characteristics of FR-beta. Folic Acid 244-250 folate receptor beta Homo sapiens 219-226 9166787-7 1997 In this fashion, it was determined that the alanine residue at position 49 in FR-alpha was critical for its functional divergence from FR-beta, since substitution at this position with Leu (the corresponding residue in FR-beta) resulted in the folate binding characteristics of FR-beta. Folic Acid 244-250 folate receptor beta Homo sapiens 219-226 9166787-8 1997 Reciprocal substitution in FR-beta with peptide 1-92 of FR-alpha resulted in poor expression of a [3H]folic acid binding protein. Folic Acid 102-112 folate receptor beta Homo sapiens 27-34 9099956-2 1997 The overexpression of FBP on the cell surface of ovarian carcinoma cells may be responsible for an increased folate uptake. Folic Acid 109-115 folate receptor beta Homo sapiens 22-25 7513252-11 1994 CONCLUSIONS: Although FR-beta is the more common isoform, FR-alpha and FR-beta are differentially regulated in normal tissues, carcinomas, nonepithelial malignancies, and immortalized cells or in response to changes in extracellular folate concentrations. Folic Acid 233-239 folate receptor beta Homo sapiens 71-78 8061055-1 1994 The folate receptor (FR), an essential component in the process of folate uptake in various cells, is known to exist in three isoforms, FR-alpha, FR-beta and FR-gamma, with differential tissue expression. Folic Acid 4-10 folate receptor beta Homo sapiens 146-153 35545363-3 2022 The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling. Folic Acid 85-95 folate receptor beta Homo sapiens 213-218 1904273-1 1991 A fluorescein derivative of the lysine analogue of folic acid, N alpha-pteroyl-N epilson-(4"-fluoresceinthiocarbamoyl)-L-lysine (PLF), was synthesized as a probe for dihydrofolate reductase (DHFR) and a membrane folate binding protein (m-FBP). Folic Acid 51-61 folate receptor beta Homo sapiens 238-241 34390827-1 2021 Activated macrophages overexpress the folate receptor beta (FR-beta) that can be used for targeted delivery of drugs conjugated to folic acid. Folic Acid 131-141 folate receptor beta Homo sapiens 38-58 35185910-3 2022 Over the past decade, selective expression of folate receptor beta (FRbeta), a glycosylphosphatidylinositol-anchored plasma membrane protein, on myeloid cells has emerged as an attractive target for macrophage imaging by exploiting the high binding affinity of folate-based PET tracers. Folic Acid 261-267 folate receptor beta Homo sapiens 46-66 35545363-3 2022 The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling. Folic Acid 185-195 folate receptor beta Homo sapiens 213-218 35545363-3 2022 The purpose of this study is to investigate the association between periconceptional folic acid supplement, the genetic polymorphisms of maternal folic acid receptor 1 gene (FOLR1) and folic acid receptor 2 gene (FOLR2) and the impact of their interaction on the risk of CHD in offspring, and to provide epidemiological evidence for individualized folic acid dosing in hygienic counseling. Folic Acid 348-358 folate receptor beta Homo sapiens 213-218 2536692-6 1989 The apparent 160-kDa species specifically bound radiolabeled folates and were specifically immunoprecipitated by rabbit anti-40-kDa FBP antiserum. Folic Acid 61-68 folate receptor beta Homo sapiens 132-135 2557328-5 1989 In addition, virtually all of the folate binding sites on the plasma membrane of the intact cells were released as soluble, functional FBP following treatment with PI-PLC. Folic Acid 34-40 folate receptor beta Homo sapiens 135-138 32581311-2 2020 While several studies have reported that FOLR1 and FOLR2 import folic acid into cells, the role of FOLR3 remains unknown. Folic Acid 64-74 folate receptor beta Homo sapiens 51-56 2878641-10 1986 The results also suggest a role for human milk FBP in regulating the nutritional bioavailability of folate. Folic Acid 100-106 folate receptor beta Homo sapiens 47-50 3767384-6 1986 The association constants for pteroylglutamic acid of the FBPs in the 200,000 g cell lysate supernate, culture medium, and Triton-solubilized membrane were similar and the relative affinity of folate analogs for the FBP, vis-a-vis pteroylglutamic acid, was similar for all species. Folic Acid 30-50 folate receptor beta Homo sapiens 58-61 3767384-6 1986 The association constants for pteroylglutamic acid of the FBPs in the 200,000 g cell lysate supernate, culture medium, and Triton-solubilized membrane were similar and the relative affinity of folate analogs for the FBP, vis-a-vis pteroylglutamic acid, was similar for all species. Folic Acid 193-199 folate receptor beta Homo sapiens 58-61 3767384-6 1986 The association constants for pteroylglutamic acid of the FBPs in the 200,000 g cell lysate supernate, culture medium, and Triton-solubilized membrane were similar and the relative affinity of folate analogs for the FBP, vis-a-vis pteroylglutamic acid, was similar for all species. Folic Acid 231-251 folate receptor beta Homo sapiens 58-61 3767384-11 1986 After 16 weeks of culture in D medium, the total folate binding capacity of the membrane-associated FBP was twofold greater than that of normal KB cells, indicating the induction of FBP. Folic Acid 49-55 folate receptor beta Homo sapiens 100-103 6947034-2 1981 This binder is similar to a previously purified protein from CML cells (FBP-L) in its molecular weight and affinity for folate analogues. Folic Acid 120-126 folate receptor beta Homo sapiens 72-75 427038-5 1979 Specific FBP thus functions to deliver folate to stores and represents a storage pool of folate. Folic Acid 39-45 folate receptor beta Homo sapiens 9-12 427038-5 1979 Specific FBP thus functions to deliver folate to stores and represents a storage pool of folate. Folic Acid 89-95 folate receptor beta Homo sapiens 9-12 427038-6 1979 The non-specific FBP are responsible for the delivery of folate to the fetus, and probably also to sites of utilization. Folic Acid 57-63 folate receptor beta Homo sapiens 17-20 32919191-6 2020 Folate receptor-beta (FR-beta) is a cell surface glycosylphosphatidylinositol-anchored glycoprotein that can mediate the unidirectional transport of folate into cells. Folic Acid 149-155 folate receptor beta Homo sapiens 0-20 29435118-9 2018 Overall, these data suggest that an independent analysis of both FR-alpha and FR-beta should be obtained to predict the potential efficacy of a folate-targeted drug. Folic Acid 144-150 folate receptor beta Homo sapiens 78-85 30280318-5 2019 FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs). Folic Acid 48-58 folate receptor beta Homo sapiens 0-6 30280318-5 2019 FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs). Folic Acid 128-134 folate receptor beta Homo sapiens 0-6 30280318-5 2019 FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs). Folic Acid 192-198 folate receptor beta Homo sapiens 0-6 30280318-5 2019 FRbeta harbors a nanomolar binding affinity for folic acid allowing this receptor to be exploited for RA disease imaging (e.g., folate-conjugated PET tracers) and therapeutic targeting (e.g., folate antagonists and folate-conjugated drugs). Folic Acid 192-198 folate receptor beta Homo sapiens 0-6 29616859-3 2018 FR-alpha and FR-beta are present on many cancers with little expression in normal tissues; leading to the testing of at least six folate-targeted drugs in human clinical trials for various cancers. Folic Acid 130-136 folate receptor beta Homo sapiens 13-20 24446917-4 2014 The present study quantitates the number of cell surface FR-alpha and FR-beta following exposure to saturating concentrations of a variety of folate-linked molecules and anti-FR antibodies, including the unmodified vitamin, folate-linked drug mimetics, multifolate derivatized nanoparticles, and monoclonal antibodies to FR. Folic Acid 142-148 folate receptor beta Homo sapiens 70-77 28948692-2 2017 Folate transporters (SLC19A1, SLC46A1, SLC25A32, and FOLH1) and folate receptors (FOLR1, FOLR2, and FOLR3) are suggested to play essential roles in transporting folate from maternal intestinal lumen to the developing embryo. Folic Acid 64-70 folate receptor beta Homo sapiens 89-94 26090596-1 2015 Folate receptors alpha (FRalpha) and beta (FRbeta) are two isoforms of the cell surface glycoprotein that binds folate. Folic Acid 112-118 folate receptor beta Homo sapiens 43-49 24448885-2 2014 We hypothesized that tumor infiltrating inflammatory cells expressing FR-beta could allow fluorescent visualization of HNSCC tumors using folate conjugated dyes even when FR expression in cancer cells is low. Folic Acid 138-144 folate receptor beta Homo sapiens 70-77 24448885-12 2014 Folate conjugated fluorescent dye is able to specifically target and label tumor xenografts to permit macroscopic fluorescence imaging due to FR-beta expression on the infiltrating inflammatory cells. Folic Acid 0-6 folate receptor beta Homo sapiens 142-149 28939533-3 2017 This requires considering a set of experimentally validated protein targets in the folate pathway of major pathogenic trypanosomatid parasites and humans: (i) the primary parasite on-targets: pteridine reductase 1 (PTR1) (absent in humans) and bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS), (ii) the primary off-targets: human DHFR and TS, and (iii) the secondary on-target: human folate receptor beta, a folate/antifolate transporter. Folic Acid 83-89 folate receptor beta Homo sapiens 403-423 28472749-5 2017 In this study, we evaluate the efficiency of folate-targeted liposomes for specific delivery of siRNA to activated macrophages, key effector cells in rheumatoid arthritis (RA) pathology which specifically express folate receptor beta (FRbeta). Folic Acid 45-51 folate receptor beta Homo sapiens 213-233 28472749-5 2017 In this study, we evaluate the efficiency of folate-targeted liposomes for specific delivery of siRNA to activated macrophages, key effector cells in rheumatoid arthritis (RA) pathology which specifically express folate receptor beta (FRbeta). Folic Acid 45-51 folate receptor beta Homo sapiens 235-241 26248049-5 2015 Additional or simultaneous expression of FR-beta could help extend the indications for folate-based drugs and imaging agents. Folic Acid 87-93 folate receptor beta Homo sapiens 41-48 25359878-2 2014 Activated macrophages express folate receptor-beta (FR-beta), which can be targeted by folate coupled to radioactive ligands to visualize vulnerability. Folic Acid 30-36 folate receptor beta Homo sapiens 52-59 24622812-4 2014 In this study, we determined the presence of FR-beta-expressing macrophages in atherosclerotic lesions by the use of a fluorine-18-labeled folate-based radiotracer. Folic Acid 139-145 folate receptor beta Homo sapiens 45-52 24622812-13 2014 Selectively targeting FR-beta-positive macrophages through folate-based radiopharmaceuticals may be useful for noninvasive imaging of plaque inflammation. Folic Acid 59-65 folate receptor beta Homo sapiens 22-29