PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12697024-13 2003 Phosphorylation of GNMT would thus seem to play no role in regulation of the intracellular AdoMet/AdoHcy ratio, but could be involved in other GNMT functions, such as the binding of folates or aromatic hydrocarbons. Folic Acid 182-189 glycine N-methyltransferase Rattus norvegicus 19-23 10751329-0 2000 Folate deficiency reduces the GPI-anchored folate-binding protein in rat renal tubules. Folic Acid 0-6 glycine N-methyltransferase Rattus norvegicus 43-65 12566489-2 2003 Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply. Folic Acid 5-11 glycine N-methyltransferase Rattus norvegicus 46-68 12566489-2 2003 Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply. Folic Acid 5-11 glycine N-methyltransferase Rattus norvegicus 70-73 12566489-2 2003 Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply. Folic Acid 5-11 glycine N-methyltransferase Rattus norvegicus 103-106 12566489-2 2003 Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply. Folic Acid 46-52 glycine N-methyltransferase Rattus norvegicus 70-73 12566489-2 2003 Milk folate is entirely bound by an excess of folate-binding protein (FBP), prompting speculation that FBP may affect the bioavailability of the limited folate supply. Folic Acid 46-52 glycine N-methyltransferase Rattus norvegicus 103-106 12566489-3 2003 Previous research has shown that FBP-bound folic acid is more gradually absorbed, thereby reducing the peak plasma folate concentration and preventing loss into the urine. Folic Acid 43-53 glycine N-methyltransferase Rattus norvegicus 33-36 12566489-3 2003 Previous research has shown that FBP-bound folic acid is more gradually absorbed, thereby reducing the peak plasma folate concentration and preventing loss into the urine. Folic Acid 115-121 glycine N-methyltransferase Rattus norvegicus 33-36 12566489-5 2003 We studied the effect of FBP on folate nutrition of rats in both single-dose and 4-wk feeding experiments. Folic Acid 32-38 glycine N-methyltransferase Rattus norvegicus 25-28 12566489-7 2003 FBP increased bioavailability of dietary folate when it was consumed with other whey proteins or with soluble casein. Folic Acid 41-47 glycine N-methyltransferase Rattus norvegicus 0-3 12566489-10 2003 They suggest that the addition of FBP-rich foods to folate-rich foods could enhance the bioavailability of natural folates, but that the outcome of such a combination would depend on interactions with other components of the diet. Folic Acid 115-122 glycine N-methyltransferase Rattus norvegicus 34-37 12221207-2 2002 In liver, methionine availability, both from the diet and via the folate-dependent one-carbon pool, modulates GNMT activity to maintain an optimal SAM:SAH ratio. Folic Acid 66-72 glycine N-methyltransferase Rattus norvegicus 110-114 12054489-3 2002 Inappropriate regulation of GNMT may have negative consequences on methyl group and folate metabolism. Folic Acid 84-90 glycine N-methyltransferase Rattus norvegicus 28-32 10751329-7 2000 Because the GPI-FBP is on the brush borders of the proximal renal tubules and provides for the reabsorption of folate, this function diminishes when the protein decreases in folate deficiency. Folic Acid 111-117 glycine N-methyltransferase Rattus norvegicus 16-19 10751329-7 2000 Because the GPI-FBP is on the brush borders of the proximal renal tubules and provides for the reabsorption of folate, this function diminishes when the protein decreases in folate deficiency. Folic Acid 174-180 glycine N-methyltransferase Rattus norvegicus 16-19 8447363-1 1993 Folate-binding protein (FBP) is involved in folate reabsorption in the renal proximal tubule. Folic Acid 44-50 glycine N-methyltransferase Rattus norvegicus 0-22 10608809-3 1999 We now report that the inhibition of glycine N-methyltransferase by (6S)-5-CH(3)-H(4)PteGlu(5) is noncompetitive with regard to both S-adenosylmethionine and glycine. Folic Acid 85-91 glycine N-methyltransferase Rattus norvegicus 37-64 8810903-8 1996 (2) This unique molecular structure can explain why GNMT can capture folate and polycyclic aromatic hydrocarbons. Folic Acid 69-75 glycine N-methyltransferase Rattus norvegicus 52-56 8547345-3 1996 The apo-form of the folate binding protein thus obtained was purified by affinity chromatography using pteroylglutamic acid covalently coupled to Sepharose 4B. Folic Acid 103-123 glycine N-methyltransferase Rattus norvegicus 20-42 8471033-13 1993 The increased GNMT activity is therefore consistent with decreased folate levels and decreased inhibition of enzyme activity. Folic Acid 67-73 glycine N-methyltransferase Rattus norvegicus 14-18 8447363-1 1993 Folate-binding protein (FBP) is involved in folate reabsorption in the renal proximal tubule. Folic Acid 44-50 glycine N-methyltransferase Rattus norvegicus 24-27 8447363-6 1993 The results are consistent with reabsorption of folate through endocytosis of the FBP-folate complex followed by dissociation and recycling of FBP. Folic Acid 48-54 glycine N-methyltransferase Rattus norvegicus 82-85 8447363-6 1993 The results are consistent with reabsorption of folate through endocytosis of the FBP-folate complex followed by dissociation and recycling of FBP. Folic Acid 48-54 glycine N-methyltransferase Rattus norvegicus 143-146 8447363-6 1993 The results are consistent with reabsorption of folate through endocytosis of the FBP-folate complex followed by dissociation and recycling of FBP. Folic Acid 86-92 glycine N-methyltransferase Rattus norvegicus 82-85 2843025-1 1988 The folate in milk is largely bound to high-affinity folate-binding protein (FBP). Folic Acid 4-10 glycine N-methyltransferase Rattus norvegicus 53-75 1996614-6 1991 These data support a mechanism of receptor-mediated endocytosis for the process of FBP-mediated folate transport in the kidney. Folic Acid 96-102 glycine N-methyltransferase Rattus norvegicus 83-86 6427219-7 1984 Chloride ion was also found to lower the dissociation constant of the folic acid-FBP complex at 50 degrees C by about 10-fold. Folic Acid 70-80 glycine N-methyltransferase Rattus norvegicus 81-84 3565583-3 1987 Surface proximal convoluted tubules (PCT) in rats were microinfused in situ with [3H]folic acid to study the role of folate binding protein (FBP) in the kidney brush-border membrane for renal conservation and transport of folate [3H]folic acid absorption was linearly related to tubular length of PCT and occurred largely in this segment of the tubule. Folic Acid 117-123 glycine N-methyltransferase Rattus norvegicus 141-144 3565583-7 1987 It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface. Folic Acid 76-86 glycine N-methyltransferase Rattus norvegicus 37-40 3565583-7 1987 It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface. Folic Acid 76-86 glycine N-methyltransferase Rattus norvegicus 147-150 3565583-7 1987 It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface. Folic Acid 136-146 glycine N-methyltransferase Rattus norvegicus 37-40 3565583-7 1987 It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface. Folic Acid 136-146 glycine N-methyltransferase Rattus norvegicus 147-150 3565583-7 1987 It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface. Folic Acid 136-146 glycine N-methyltransferase Rattus norvegicus 37-40 3565583-7 1987 It is proposed that the brush-border FBP functions as a receptor of infused folic acid and that following the binding of the ligand the folic acid/FBP complex undergoes a rapid change that results in the internalization of folic acid and regeneration of unsaturated binding sites at the membrane surface. Folic Acid 136-146 glycine N-methyltransferase Rattus norvegicus 147-150 3966077-12 1985 The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general. Folic Acid 264-271 glycine N-methyltransferase Rattus norvegicus 29-51 3966077-12 1985 The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general. Folic Acid 264-271 glycine N-methyltransferase Rattus norvegicus 212-234 3966077-12 1985 The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general. Folic Acid 29-35 glycine N-methyltransferase Rattus norvegicus 212-234 3966077-12 1985 The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general. Folic Acid 370-377 glycine N-methyltransferase Rattus norvegicus 29-51 3966077-12 1985 The greater concentration of folate binding protein in the renal tubule cell brush border membrane preparations as compared to those from basolateral membranes ascribes, for the first time, a functional role for folate binding protein in the renal reabsorption of folates which is required to prevent loss of folate in the urine and perhaps in the membrane transport of folates in general. Folic Acid 370-377 glycine N-methyltransferase Rattus norvegicus 212-234 6587377-3 1984 Purification of glycine N-methyltransferase resulted in the separation of two enzyme species, one that contained bound folate and one that did not. Folic Acid 119-125 glycine N-methyltransferase Rattus norvegicus 16-43 6716181-5 1984 The similar effect of FBP was also observed when the biliary excretion of 3H-labeled folate compounds was investigated in situ. Folic Acid 85-91 glycine N-methyltransferase Rattus norvegicus 22-25 6716181-6 1984 Furthermore, the incorporation of [3H]PteGlu into folate-requiring intestinal microorganisms was considerably reduced when it was bound to FBP. Folic Acid 50-56 glycine N-methyltransferase Rattus norvegicus 139-142 6716181-7 1984 These results suggest that milk FBP has some nutritional effects on the bioavailability of folate in vivo. Folic Acid 91-97 glycine N-methyltransferase Rattus norvegicus 32-35 3838667-0 1985 Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism. Folic Acid 54-60 glycine N-methyltransferase Rattus norvegicus 14-41 6427219-8 1984 This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex. Folic Acid 69-79 glycine N-methyltransferase Rattus norvegicus 65-68 6427219-8 1984 This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex. Folic Acid 69-79 glycine N-methyltransferase Rattus norvegicus 129-132 6427219-8 1984 This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex. Folic Acid 133-143 glycine N-methyltransferase Rattus norvegicus 65-68 6427219-8 1984 This effect is thought to derive from the formation of a ternary FBP-folic acid-Cl- complex which is more stable than the binary FBP-folic acid complex. Folic Acid 133-143 glycine N-methyltransferase Rattus norvegicus 129-132 18008023-5 2007 At the molecular level, reduced folate transport activity in renal tissue during chronic ethanol ingestion was attributable to decreased expression of reduced folate carrier (RFC) and folate binding protein (FBP). Folic Acid 32-38 glycine N-methyltransferase Rattus norvegicus 184-206 6897000-3 1982 This folate binding protein was initially identified during purification by an in vivo labeling procedure involving intraperitoneal injection of [3H]folic acid prior to sacrifice and subsequently by its ability to bind naturally reduced [3H]folate polyglutamates in vitro. Folic Acid 145-159 glycine N-methyltransferase Rattus norvegicus 5-27 22037183-0 2012 Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. Folic Acid 15-21 glycine N-methyltransferase Rattus norvegicus 110-137 22037183-8 2012 We show that in the folate-GNMT complexes with the native enzyme, two folate molecules establish three and four hydrogen bonds with the protein. Folic Acid 20-26 glycine N-methyltransferase Rattus norvegicus 27-31 22037183-8 2012 We show that in the folate-GNMT complexes with the native enzyme, two folate molecules establish three and four hydrogen bonds with the protein. Folic Acid 70-76 glycine N-methyltransferase Rattus norvegicus 27-31 22037183-9 2012 In the folate-recombinant GNMT complex only one hydrogen bond is established. Folic Acid 7-13 glycine N-methyltransferase Rattus norvegicus 26-30 22037183-10 2012 This difference results in more effective inhibition by folate of the native liver GNMT activity compared to the recombinant enzyme. Folic Acid 56-62 glycine N-methyltransferase Rattus norvegicus 83-87 21730260-3 2011 We have shown previously that diabetes induces GNMT expression and reduces plasma homocysteine pools by stimulating both its catabolism and folate-independent remethylation. Folic Acid 140-146 glycine N-methyltransferase Rattus norvegicus 47-51 18008023-5 2007 At the molecular level, reduced folate transport activity in renal tissue during chronic ethanol ingestion was attributable to decreased expression of reduced folate carrier (RFC) and folate binding protein (FBP). Folic Acid 32-38 glycine N-methyltransferase Rattus norvegicus 208-211 17158459-3 2007 GNMT also links utilization of preformed methyl groups, in the form of methionine, to their de novo synthesis, because it is inhibited by a specific form of folate, 5-methyltetrahydrofolate. Folic Acid 157-163 glycine N-methyltransferase Rattus norvegicus 0-4 17158459-6 2007 In the GNMT-folate complex, two folate binding sites were located in the intersubunit areas of the tetramer. Folic Acid 12-18 glycine N-methyltransferase Rattus norvegicus 7-11 17158459-9 2007 Binding experiments in solution also confirm that one GNMT tetramer binds two folate molecules. Folic Acid 78-84 glycine N-methyltransferase Rattus norvegicus 54-58 16835399-0 2006 Folate status modulates the induction of hepatic glycine N-methyltransferase and homocysteine metabolism in diabetic rats. Folic Acid 0-6 glycine N-methyltransferase Rattus norvegicus 49-76 16835399-1 2006 A diabetic state induces the activity and abundance of glycine N-methyltransferase (GNMT), a key protein in the regulation of folate, methyl group, and homocysteine metabolism. Folic Acid 126-132 glycine N-methyltransferase Rattus norvegicus 55-82 16835399-1 2006 A diabetic state induces the activity and abundance of glycine N-methyltransferase (GNMT), a key protein in the regulation of folate, methyl group, and homocysteine metabolism. Folic Acid 126-132 glycine N-methyltransferase Rattus norvegicus 84-88 16835399-2 2006 Because the folate-dependent one-carbon pool is a source of methyl groups and 5-methyltetrahydrofolate allosterically inhibits GNMT, the aim of this study was to determine whether folate status has an impact on the interaction between diabetes and methyl group metabolism. Folic Acid 96-102 glycine N-methyltransferase Rattus norvegicus 127-131 16835399-4 2006 The activities of GNMT, phosphatidylethanolamine N-methyltransferase (PEMT), and betaine-homocysteine S-methyltransferase (BHMT) were increased about twofold in diabetic rat liver; folate deficiency resulted in the greatest elevation in GNMT activity. Folic Acid 181-187 glycine N-methyltransferase Rattus norvegicus 18-22 16632891-5 2006 The activity of hepatic glycine N-methyltransferase (GNMT), an enzyme involved in the regulation of tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), was increased by folate deficiency (p < 0.006) and decreased by selenium deprivation (p < 0.0003). Folic Acid 185-191 glycine N-methyltransferase Rattus norvegicus 24-51 16632891-5 2006 The activity of hepatic glycine N-methyltransferase (GNMT), an enzyme involved in the regulation of tissue S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH), was increased by folate deficiency (p < 0.006) and decreased by selenium deprivation (p < 0.0003). Folic Acid 185-191 glycine N-methyltransferase Rattus norvegicus 53-57