PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19822838-5 2009 Among individuals not receiving folic acid, there was a 4% decrease (mean ratio of year 3 to baseline levels = 0.96, 95% confidence interval [CI] = 0.82 to 1.14) in CRP for a period of 3 years in the 325 mg of aspirin group vs a 20% increase (mean ratio = 1.20, 95% CI = 1.03 to 1.41) in the placebo group (P = .027). Folic Acid 32-42 C-reactive protein Homo sapiens 165-168 19822838-8 2009 Low-dose aspirin (325 mg/d) is beneficial in stabilizing CRP levels, which may be abrogated by folate. Folic Acid 95-101 C-reactive protein Homo sapiens 57-60 18299144-5 2008 CONCLUSION: In elderly AMI patients the concomitant elevation of CRP and tHcy, associated with folate and vitamin B12 low levels, could be considered a significant predictive heart mortality risk factor. Folic Acid 95-101 C-reactive protein Homo sapiens 65-68 19248856-8 2009 Serum C-reactive protein was significantly inversely associated with intakes of fruit (r=-0.19; P=0.004), vitamin C (r=-0.13, P=0.03), and folate (r=-0.18; P=0.004). Folic Acid 139-145 C-reactive protein Homo sapiens 6-24 17311055-6 2008 Especially vitamin E in combination with other vitamins like vitamin C, vitamin B(1), B(2), B(6), B(12), niacin, folic acid, pantothenic acid and selenium, was significantly associated with lower CRP levels. Folic Acid 113-123 C-reactive protein Homo sapiens 196-199 18024309-4 2007 RESULTS: Serum CRP level was comparable between the two groups before the treatment, but significantly reduced after vitamin B6 and folic acid treatment (7.56-/+2.94 mg/L vs 12.23-/+4.16 mg/L, P<0.05). Folic Acid 132-142 C-reactive protein Homo sapiens 15-18 18024309-5 2007 Additional vitamin B6 and folic acid treatment significantly lowered plasma HCA level (4.56-/+1.14 micromol/L vs 7.79-/+1.79 micromol/L, P<0.05), and correlation analysis demonstrated a positive correlation between plasma HCA and serum CRP levels (r=0.697, P<0.01). Folic Acid 26-36 C-reactive protein Homo sapiens 239-242 35383339-8 2022 Also, folate supplementation resulted in a significant improvement in the quantitative insulin sensitivity check index (P = 0.002) and total antioxidant capacity (P = 0.04) and a significant reduction in high-sensitivity C-reactive protein (P = 0.015) in comparison with the placebo group. Folic Acid 6-12 C-reactive protein Homo sapiens 221-239 17605895-0 2007 Effects of folic acid and vitamin B complex on serum C-reactive protein and albumin levels in stable hemodialysis patients. Folic Acid 11-21 C-reactive protein Homo sapiens 53-71 16491109-8 2006 RESULTS: Subjects receiving folic acid supplementation showed a decrement of homocysteine and an amelioration of insulin sensitivity; this treatment was also associated with a significant drop in the circulating concentration of monocyte chemoattractant protein-1, interleukin-8 and C-reactive protein, in the absence of any significant variation of BMI or fat mass. Folic Acid 28-38 C-reactive protein Homo sapiens 283-301 15057566-5 2005 C-reactive protein levels also correlated significantly in a negative manner with vitamin B12 and folate but positively with tHcy. Folic Acid 98-104 C-reactive protein Homo sapiens 0-18 34857394-4 2021 All randomized controlled trials that examined the influence of folic acid supplementation on C-reactive protein, interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) were included. Folic Acid 64-74 C-reactive protein Homo sapiens 94-112 34857394-7 2021 Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference (MD), -0.21 mg/L; 95% CI, -0.41 to -0.01; n = 16), TNF-alpha (MD, -14.88 pg/mL; 95% CI, -23.68 to -6.09; n = 10), and IL-6 (MD, -0.93 pg/mL; 95% CI, -1.72 to -0.14; n = 11). Folic Acid 0-10 C-reactive protein Homo sapiens 65-83 17237316-0 2007 Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program. Folic Acid 32-42 C-reactive protein Homo sapiens 95-113 15668660-6 2005 Bivariate analysis showed a significant inverse association between CRP and many nutrients (e.g., carbohydrates, proteins, lipids, thiamine, pyridoxine, tocopherol, and folate), but multiple-regression analysis indicated that only the effect of dietary folate intake was not dependent on other factors. Folic Acid 169-175 C-reactive protein Homo sapiens 68-71 15668660-9 2005 This population-based study shows that a higher folate intake, in addition to other known constitutive and lifestyle factors, is significantly associated with a lower serum CRP concentration. Folic Acid 48-54 C-reactive protein Homo sapiens 173-176 34331825-8 2021 Furthermore, an inverse association was observed between high dietary intake of vitamin B6 (OR vitaminB6 : 0.28; 95% CI: 0.08, 1.00; P=0.05) and vitamin B9 (OR vitaminB9 : 0.20; 95% CI: 0.06, 0.70; P=0.01) with hs-CRP level. Folic Acid 145-155 C-reactive protein Homo sapiens 214-217 34371837-3 2021 To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Folic Acid 143-153 C-reactive protein Homo sapiens 222-240 34371837-3 2021 To bridge this knowledge gap, this systematic review and meta-analysis of randomized controlled trials (RCTs) aimed to evaluate the effects of folic acid supplementation on serum concentrations of the inflammatory markers C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha). Folic Acid 143-153 C-reactive protein Homo sapiens 242-245 34371837-8 2021 The dose-response analysis demonstrated a significant relationship between an elevated dosage of folic acid supplementation and lower CRP concentrations (p = 0.002). Folic Acid 97-107 C-reactive protein Homo sapiens 134-137 34371837-9 2021 Conclusions: We found that folic acid supplementation may improve inflammation by attenuating serum concentrations of CRP but without significant effects on IL-6 and TNF-alpha. Folic Acid 27-37 C-reactive protein Homo sapiens 118-121 34611067-0 2021 The Relationship between Folic Acid and Vitamin B12 Serum Levels with High Sensitivity C-reactive Protein and Homocysteine in Chronic Hemodialysis Patients: A Cross-sectional Study. Folic Acid 25-35 C-reactive protein Homo sapiens 87-105 33926518-9 2021 Although erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) had a weak correlation with PGA, they were not statistically correlated with GS, PD, or GSPD. Folic Acid 103-106 C-reactive protein Homo sapiens 50-68 33926518-9 2021 Although erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) had a weak correlation with PGA, they were not statistically correlated with GS, PD, or GSPD. Folic Acid 103-106 C-reactive protein Homo sapiens 70-73 32737139-10 2020 Among supplement users, folate intake was inversely associated with serum C-reactive protein levels (P trend < 0.01). Folic Acid 24-30 C-reactive protein Homo sapiens 74-92 33525287-9 2020 Moreover, there was a significant inverse correlation between serum folate levels and C-reactive protein in IBD patients (r = -0.563 p =0.001). Folic Acid 68-74 C-reactive protein Homo sapiens 86-104 33026590-9 2021 In a multiple logistic regression model, increased CRP levels were significantly associated with deficiencies of vitamin B12 (OR = 5.84; 95% CI 1.25-27.2; p = 0.024), folate (OR = 4.02; 1.87-8.66; p < 0.001), and with the presence of >= 2 micronutrient deficiencies (OR = 2.31; 1.21-4.42; p = 0.01). Folic Acid 167-173 C-reactive protein Homo sapiens 51-54 30940490-0 2019 Effects of folic acid supplementation on C-reactive protein: A systematic review and meta-analysis of randomized controlled trials. Folic Acid 11-21 C-reactive protein Homo sapiens 41-59 32722447-5 2020 The association between the serum folate level and lung function in patients with COPD was evaluated using multivariable linear regression analysis after adjustment for age, sex, height, high sensitivity C-reactive protein, total calorie intake, residence, smoking status and smoking pack-years, education, and household income. Folic Acid 34-40 C-reactive protein Homo sapiens 204-222 32266401-8 2020 Similarly, correlations between CRP and serum folate ranged from -0.13 to 0.08, and correlations between AGP and serum folate between -0.21 and 0.02. Folic Acid 46-52 C-reactive protein Homo sapiens 32-35 30935429-7 2019 However, there were statistically significant interactions on both multiplicative and additive scale between serum folate and C-reactive protein (CRP) levels or smoking status and the associations of lower serum folate with worse LCSS and OS were only evident among patients with CRP &gt; 3 0 mg/l or current smokers. Folic Acid 212-218 C-reactive protein Homo sapiens 146-149 30935429-7 2019 However, there were statistically significant interactions on both multiplicative and additive scale between serum folate and C-reactive protein (CRP) levels or smoking status and the associations of lower serum folate with worse LCSS and OS were only evident among patients with CRP &gt; 3 0 mg/l or current smokers. Folic Acid 212-218 C-reactive protein Homo sapiens 280-283 30940490-1 2019 BACKGROUND AND AIM: Given the contradictory results of previous randomized controlled trials (RCTs), we performed a systematic review and meta-analysis to quantify and summarize the effects of folic acid supplementation on C-reactive protein (CRP). Folic Acid 193-203 C-reactive protein Homo sapiens 223-241 30940490-1 2019 BACKGROUND AND AIM: Given the contradictory results of previous randomized controlled trials (RCTs), we performed a systematic review and meta-analysis to quantify and summarize the effects of folic acid supplementation on C-reactive protein (CRP). Folic Acid 193-203 C-reactive protein Homo sapiens 243-246 30940490-3 2019 RCTs that investigated the effect of folate on CRP were included in the present study. Folic Acid 37-43 C-reactive protein Homo sapiens 47-50 30940490-7 2019 Pooled analysis results showed that folate supplementation significantly lowered the serum CRP level (weighted mean difference (WMD): -0.685 mg/l, 95% CI: -1.053, -0.318, p < 0.001). Folic Acid 36-42 C-reactive protein Homo sapiens 91-94 30940490-11 2019 CONCLUSION: This meta-analysis suggested that folic acid supplementation could significantly lower the serum CRP level. Folic Acid 46-56 C-reactive protein Homo sapiens 109-112 30940490-12 2019 Folic acid leads to greater CRP lowering effect in women, patients with T2DM, and those with less than 12-week intervention. Folic Acid 0-10 C-reactive protein Homo sapiens 28-31 26094490-8 2015 In folic acid supplement users compared to nonusers, we established a lower abundance of C-reactive protein (-2.03; P = < 0.01) and higher abundances of apolipoproteins from high-density lipoprotein (HDL), most notably A-I (+1.28; P = < 0.01) and C-I (+1.11; P = 0.016). Folic Acid 3-13 C-reactive protein Homo sapiens 89-107 30415553-7 2018 Additionally, folic acid intake resulted in a significant reduction in serum high sensitivity C-reactive protein (hs-CRP) (beta -0.36 mg/L; 95% CI, -0.52, -0.21; P < 0.001) compared with the placebo. Folic Acid 14-24 C-reactive protein Homo sapiens 94-112 28603593-7 2017 Folic acid concentration [5.4 (4.4-7.9) ng/mL vs 12.2 (8.0-14.2) ng/mL, P < 0.01] resulted to be lower and High-sensitivity C reactive protein levels higher (4.21 +- 6.47 mg/L vs 0.98 +- 1.13 mg/L, P < 0.01) in the patient group. Folic Acid 0-10 C-reactive protein Homo sapiens 127-145 29439678-5 2018 RESULTS: With adjustment for lifestyle-related factors, including folate intake, the global DNA methylation level of peripheral blood leukocytes was significantly but weakly increased by 0.43% per quartile category for CRP (P for trend = 0.010). Folic Acid 66-72 C-reactive protein Homo sapiens 219-222 28498159-11 2017 CRP only significantly correlated with FC (P = 0.0007) and PGA in the second trimester (P = 0.0003). Folic Acid 59-62 C-reactive protein Homo sapiens 0-3 23175323-0 2012 Is there an effect of folic acid supplementation on the coagulation factors and C-reactive protein concentrations in subjects with atherosclerosis risk factors? Folic Acid 22-32 C-reactive protein Homo sapiens 80-98 24422992-6 2014 Clinical response [Physician Global Assessment (PGA) "clear" or "minimal"] was associated with greater CRP reductions vs. no response (PGA "mild" or worse) overall (-0.4 vs. -0.3 mg/L) and in substudies E (-0.4 vs. -0.1 mg/L) and M (-0.5 vs. -0.2 mg/L), but not P (-0.1 vs. -0.4 mg/L). Folic Acid 48-51 C-reactive protein Homo sapiens 103-106 21244768-5 2010 CRP and homocysteine levels were higher in patients with psoriasis than in controls (5.9 +- 7.1 vs 3.1 +- 2.4 mg/L, p=0.0003 and 16.3 +- 12.8 vs 10.4 +- 4.6 umol/L, p=0.0001; mean +- SD) whereas folic acid was lower in psoriatic patients compared to controls (4.3 +- 7.2 vs 12.6 +- 7.9 p=0.006). Folic Acid 195-205 C-reactive protein Homo sapiens 0-3 21765609-5 2011 Plasma C-reactive protein levels significantly correlated with dietary intakes of vitamin C (r = -0.30, p<0.005), beta-carotene (r = -0.23, p<0.05), and folate (r = -0.31, p<0.005). Folic Acid 159-165 C-reactive protein Homo sapiens 7-25 21179048-3 2011 We examined whether folate nutrition modifies the relationship between serum CRP concentration and gestational age at delivery. Folic Acid 20-26 C-reactive protein Homo sapiens 77-80 21179048-8 2011 Serum folate concentration was negatively correlated (P < 0.01) with serum CRP concentration, and total dietary folate intake was positively correlated (P < 0.001) with serum folate concentration. Folic Acid 6-12 C-reactive protein Homo sapiens 78-81 21179048-9 2011 Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 mug dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml). Folic Acid 210-216 C-reactive protein Homo sapiens 84-87 21179048-9 2011 Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 mug dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml). Folic Acid 310-316 C-reactive protein Homo sapiens 84-87 21179048-9 2011 Multiple regression analysis after adjustment for covariates revealed that maternal CRP concentrations were negatively associated with gestational age at delivery; these negative associations existed only when folate intake during pregnancy was below the Korean estimated average requirements (520 mug dietary folate equivalent per day), and serum folate concentrations were above the normal (6 ng/ml). Folic Acid 310-316 C-reactive protein Homo sapiens 84-87 21179048-10 2011 CONCLUSIONS: We found that adequate maternal folate intake during pregnancy may have a beneficial role against shorter gestational age at delivery, which is associated with higher serum CRP concentrations in pregnant women. Folic Acid 45-51 C-reactive protein Homo sapiens 186-189