PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18599958-1 2008 When maintained on a folate-deficient, iron-rich diet, transgenic mice lacking in apolipoprotein E (ApoE-/- mice) demonstrate impaired activity of glutathione S-transferase (GST), resulting in increased oxidative species within brain tissue despite abnormally high levels of glutathione. Folic Acid 21-27 apolipoprotein E Mus musculus 82-98 17118406-0 2007 Folic acid supplementation delays atherosclerotic lesion development in apoE-deficient mice. Folic Acid 0-10 apolipoprotein E Mus musculus 72-76 30480514-0 2019 Folate-Modified Liposomes Loaded with Telmisartan Enhance Anti-Atherosclerotic Potency for Advanced Atherosclerosis in ApoE-/- Mice. Folic Acid 0-6 apolipoprotein E Mus musculus 119-123 16917148-2 2006 We demonstrate herein that dietary deprivation of folate and vitamin E, coupled with iron as a pro-oxidant, fosters an increase in nonphospho- and-phospho-tau within brain tissue of mice homozygously lacking apolipoprotein E as assayed by monoclonal antibodies Tau-1 and PHF-1, respectively. Folic Acid 50-56 apolipoprotein E Mus musculus 208-224 16910166-1 2006 Folate deficiency increases neuronal oxidative damage and potentiates the deleterious effects of apolipoprotein E (ApoE) deficiency. Folic Acid 0-6 apolipoprotein E Mus musculus 97-113 16910166-1 2006 Folate deficiency increases neuronal oxidative damage and potentiates the deleterious effects of apolipoprotein E (ApoE) deficiency. Folic Acid 0-6 apolipoprotein E Mus musculus 115-119 16910166-2 2006 Mice lacking ApoE (ApoE -/- mice) upregulate the expression and activity of another enzyme, glutathione synthase (GS), when deprived of folate, in an apparent attempt to compensate for increased oxidative damage. Folic Acid 136-142 apolipoprotein E Mus musculus 13-17 16910166-2 2006 Mice lacking ApoE (ApoE -/- mice) upregulate the expression and activity of another enzyme, glutathione synthase (GS), when deprived of folate, in an apparent attempt to compensate for increased oxidative damage. Folic Acid 136-142 apolipoprotein E Mus musculus 19-23 16910166-4 2006 Expression and activity of methylene tetrahydrofolate reductase was increased in the order ApoE +/+ < ApoE +/- < ApoE -/- in response to folate deprivation. Folic Acid 47-53 apolipoprotein E Mus musculus 91-95 16910166-4 2006 Expression and activity of methylene tetrahydrofolate reductase was increased in the order ApoE +/+ < ApoE +/- < ApoE -/- in response to folate deprivation. Folic Acid 47-53 apolipoprotein E Mus musculus 105-109 16910166-4 2006 Expression and activity of methylene tetrahydrofolate reductase was increased in the order ApoE +/+ < ApoE +/- < ApoE -/- in response to folate deprivation. Folic Acid 47-53 apolipoprotein E Mus musculus 105-109 16910166-6 2006 By contrast, expression and activity of methionine synthase decreased following folate deprivation in the order ApoE +/+ < ApoE +/- < ApoE -/-. Folic Acid 80-86 apolipoprotein E Mus musculus 112-116 16910166-6 2006 By contrast, expression and activity of methionine synthase decreased following folate deprivation in the order ApoE +/+ < ApoE +/- < ApoE -/-. Folic Acid 80-86 apolipoprotein E Mus musculus 126-130 16910166-6 2006 By contrast, expression and activity of methionine synthase decreased following folate deprivation in the order ApoE +/+ < ApoE +/- < ApoE -/-. Folic Acid 80-86 apolipoprotein E Mus musculus 126-130 12590161-3 2003 As described previously, ApoE-deficient mice displayed increased levels of the endogenous antioxidant glutathione as compared to normal mice, and increased these levels further following folate deprivation. Folic Acid 187-193 apolipoprotein E Mus musculus 25-29 17183144-6 2006 Herein, we demonstrate that dietary deficiency in folate and vitamin E increased PS-1 expression in juvenile and adult normal C57B1/6J and ApoE-/- mice and in aged normal mice. Folic Acid 50-56 apolipoprotein E Mus musculus 139-143 17183426-2 2006 Apolipoprotein E-deficient mice undergo oxidative damage and cognitive impairment when deprived of folate. Folic Acid 99-105 apolipoprotein E Mus musculus 0-16 15851851-3 2005 Mice deficient in apolipoprotein E, which provide a model for some aspects of AD, undergo increased oxidative damage to brain tissue and cognitive decline when maintained on a folate-free diet, despite a compensatory increase in glutathione synthase transcription and activity as well as increased levels of GSH. Folic Acid 176-182 apolipoprotein E Mus musculus 18-34 15201481-0 2004 Differential susceptibity of transgenic mice lacking one or both apolipoprotein alleles to folate and vitamin E deprivation. Folic Acid 91-97 apolipoprotein E Mus musculus 65-79 15201481-3 2004 Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice. Folic Acid 22-28 apolipoprotein E Mus musculus 97-101 15201481-3 2004 Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice. Folic Acid 22-28 apolipoprotein E Mus musculus 114-118 15201481-3 2004 Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice. Folic Acid 22-28 apolipoprotein E Mus musculus 114-118 15201481-3 2004 Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice. Folic Acid 139-145 apolipoprotein E Mus musculus 97-101 15201481-3 2004 Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice. Folic Acid 139-145 apolipoprotein E Mus musculus 114-118 15201481-3 2004 Dietary deficiency in folate and vitamin E has previously been shown to potentiate the impact of ApoE deficiency; ApoE-/- mice deprived of folate and vitamin E for 1 month demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to ApoE+/+ mice. Folic Acid 139-145 apolipoprotein E Mus musculus 114-118 15201481-7 2004 ApoE-/- mice, but not +/- or +/+ mice, exhibited impaired cognitive performance in maze trials when deprived of folate and vitamin E. Folic Acid 112-118 apolipoprotein E Mus musculus 0-4 14743434-5 2004 Both normal and ApoE-/- mice demonstrated increased GS activity when deprived of folate and vitamin E. Folic Acid 81-87 apolipoprotein E Mus musculus 16-20 14743434-6 2004 However, transcription was increased only in ApoE-/- mice deprived of folate and vitamin E. Folic Acid 70-76 apolipoprotein E Mus musculus 45-49 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 0-6 apolipoprotein E Mus musculus 72-88 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 0-6 apolipoprotein E Mus musculus 90-94 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 0-6 apolipoprotein E Mus musculus 97-101 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 0-6 apolipoprotein E Mus musculus 97-101 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 122-128 apolipoprotein E Mus musculus 90-94 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 122-128 apolipoprotein E Mus musculus 97-101 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 122-128 apolipoprotein E Mus musculus 97-101 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 276-282 apolipoprotein E Mus musculus 72-88 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 276-282 apolipoprotein E Mus musculus 97-101 15075443-5 2004 Folate deficiency has previously been shown to potentiate the impact of apolipoprotein E (ApoE); ApoE-/- mice deprived of folate demonstrated increased oxidative damage in brain tissue and impaired cognitive performance as compared to normal mice or to ApoE-/- mice receiving folate. Folic Acid 276-282 apolipoprotein E Mus musculus 97-101 15075443-6 2004 Herein, we demonstrate that dietary supplementation with DZA prevented both the increase in oxidative damage and impaired cognition characteristic of ApoE-/- mice following folate deprivation. Folic Acid 173-179 apolipoprotein E Mus musculus 150-154 14716026-0 2003 Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E. Folic Acid 0-6 apolipoprotein E Mus musculus 152-168 14716026-6 2003 Both normal and ApoE-/- mice displayed some cognitive impairment when deprived of folate and vitamin E and exposed to iron, but ApoE-/- mice were more severely affected. Folic Acid 82-88 apolipoprotein E Mus musculus 16-20 12480173-5 2002 However, ApoE knockout mice accumulated significantly increased TBARs following iron challenge when folic acid was withheld, and accumulated even more TBARs when both folic acid and vitamin E were withheld. Folic Acid 100-110 apolipoprotein E Mus musculus 9-13 12480173-5 2002 However, ApoE knockout mice accumulated significantly increased TBARs following iron challenge when folic acid was withheld, and accumulated even more TBARs when both folic acid and vitamin E were withheld. Folic Acid 167-177 apolipoprotein E Mus musculus 9-13 12374623-6 2002 However, combined treatment with folate deprivation and dietary iron depleted antioxidant capacity and induced oxidative damage in ApoE-deficient brains despite increased glutathione, indicating an inability to compensate for the lack of ApoE under these conditions. Folic Acid 33-39 apolipoprotein E Mus musculus 131-135 11254667-2 2001 Here we show that induction of HHcy in apoE-null mice by a diet enriched in methionine but depleted in folate and vitamins B6 and B12 increased atherosclerotic lesion area and complexity, and enhanced expression of receptor for advanced glycation end products (RAGE), VCAM-1, tissue factor, and MMP-9 in the vasculature. Folic Acid 103-109 apolipoprotein E Mus musculus 39-43 35139535-9 2022 Finally, folic acid (FA) significantly attenuated aortic valve calcification in WD-fed Apoe-/- mice through increasing DHFR and salvaging BH4 biosynthesis. Folic Acid 9-19 apolipoprotein E Mus musculus 87-91 24558445-0 2014 Recoupling of eNOS with folic acid prevents abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E null mice. Folic Acid 24-34 apolipoprotein E Mus musculus 106-122 30125807-4 2018 We aimed to investigate the effects of folic acid on injuries induced by oxidative stress that occur via an epigenetic gene silencing mechanism in ApoE knockout mice fed a high-fat diet and in human umbilical vein endothelial cells treated with oxidized low-density lipoprotein (ox-LDL). Folic Acid 39-49 apolipoprotein E Mus musculus 147-151 30125807-7 2018 Our data showed that folic acid reduced 8-OHdG levels and decreased apoptosis in the aortic tissue of ApoE-/- mice. Folic Acid 21-31 apolipoprotein E Mus musculus 102-106 28475147-6 2017 Folic acid reduced atherosclerotic lesion size in ApoE knockout mice. Folic Acid 0-10 apolipoprotein E Mus musculus 50-54 24704411-0 2014 Divergent effects of folic acid administration on inflammatory status and cholesterol levels in apoE deficient mice. Folic Acid 21-31 apolipoprotein E Mus musculus 96-100 19457069-3 2009 Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice). Folic Acid 49-55 apolipoprotein E Mus musculus 233-237 19457069-3 2009 Previous studies demonstrate that deprivation of folate and vitamin E, coupled with dietary iron as a pro-oxidant, for 1 month displayed increased presenilin 1 (PS-1) expression, gamma-secretase, and Abeta generation in mice lacking ApoE (ApoE-/- mice). Folic Acid 49-55 apolipoprotein E Mus musculus 239-251 19098360-0 2008 Folate and S-adenosylmethionine modulate synaptic activity in cultured cortical neurons: acute differential impact on normal and apolipoprotein-deficient mice. Folic Acid 0-6 apolipoprotein E Mus musculus 129-143 19098360-1 2008 Folate deficiency is accompanied by a decline in the cognitive neurotransmitter acetylcholine and a decline in cognitive performance in mice lacking apolipoprotein E (ApoE-/- mice), a low-density lipoprotein that regulates aspects of lipid metabolism. Folic Acid 0-6 apolipoprotein E Mus musculus 149-165 19098360-1 2008 Folate deficiency is accompanied by a decline in the cognitive neurotransmitter acetylcholine and a decline in cognitive performance in mice lacking apolipoprotein E (ApoE-/- mice), a low-density lipoprotein that regulates aspects of lipid metabolism. Folic Acid 0-6 apolipoprotein E Mus musculus 167-171 19098360-8 2008 Folate deprivation reversibly reduced signal frequency in ApoE+/+ cultures; SAM supplementation maintained signal frequency despite folate deprivation. Folic Acid 0-6 apolipoprotein E Mus musculus 58-62 18697859-6 2008 By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation. Folic Acid 130-136 apolipoprotein E Mus musculus 70-74 18697859-6 2008 By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation. Folic Acid 154-160 apolipoprotein E Mus musculus 70-74 18697859-6 2008 By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation. Folic Acid 154-160 apolipoprotein E Mus musculus 70-74 18697859-6 2008 By genetically increasing serum and liver total cholesterol levels in APOE-deficient mice, we modestly but significantly improved folate retention during folate depletion, suggesting that homeostasis among the homocysteine, folate and cholesterol metabolic pathways contributes to the beneficial effects of dietary folate supplementation. Folic Acid 154-160 apolipoprotein E Mus musculus 70-74