PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12416030-0 2002 Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothionein II and folate receptor alpha that, upon folate repletion, confer drug resistance to CHL cells. Folic Acid 7-13 folate receptor alpha Cricetulus griseus 262-283 11241661-0 2001 The rate of folate receptor alpha (FR alpha) synthesis in folate depleted CHL cells is regulated by a translational mechanism sensitive to media folate levels, while stable overexpression of its mRNA is mediated by gene amplification and an increase in transcript half-life. Folic Acid 58-64 folate receptor alpha Cricetulus griseus 12-33