PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18078840-12	2008	From the clinical point of view, the folate sensitive rare fragile site FRAXA is the most important fragile site as it is associated with the fragile X syndrome, the most common form of familial mental retardation, affecting about 1/4000 males and 1/6000 females.	Folic Acid	37-43	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	72-77	
22065534-2	2011	The folate-sensitive fragile site FRAXE is located in Xq28 approximately 600 kb distal to the fragile X syndrome fragile site (FRAXA) and harbors an unstable GCC (CCG) triplet repeat adjacent to a CpG island in the 5" untranslated region of the AFF2 (FMR2) gene.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	127-132	
21739597-1	2011	The fragile X syndrome, fragile X tremor ataxia syndrome, and premature ovarian insufficiency are conditions related to the X chromosome folate-sensitive fragile site FRAXA.	Folic Acid	137-143	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	167-172	
32601218-9	2020	We propose that break-induced DNA replication is required for the replication of FRAXA under folate stress and define a cellular function for human SLX1.	Folic Acid	93-99	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	81-86	
30509972-4	2018	Many RFSs, as exemplified by expansion of a CGG trinucleotide repeat sequence in the fragile X syndrome-associated FRAXA locus, exhibit fragility in response to folate deficiency or other forms of "folate stress."	Folic Acid	161-167	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	115-120	
24419320-2	2014	Such alleles are associated with a fragile site, FRAXA, a gap or constriction in the chromosome that is coincident with the repeat and is induced by folate stress or thymidylate synthase inhibitors like fluorodeoxyuridine (FdU).	Folic Acid	149-155	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	49-54	
15203205-2	2004	Expansion of CGG/CCG repeats has been shown to be the molecular basis of all five folate-sensitive fragile sites characterized molecularly so far, i.e., FRAXA, FRAXE, FRAXF, FRA11B, and FRA16A.	Folic Acid	82-88	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	153-158	
7874164-1	1994	Three folate-sensitive fragile sites, termed FRAXA, FRAXE and FRAXF, have been identified on the distal end of chromosome Xq.	Folic Acid	6-12	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	45-50	
10601577-1	2000	The folate-sensitive fragile site FRAXE is located in proximal Xq28 of the human X chromosome and lies approximately 600 kb distal to the fragile X syndrome (FRAXA) fragile site at Xq27.3.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	158-163	
9384610-2	1998	Most patients have a mutation in the 5" untranslated region of the FMR1 gene, consisting of the amplification of a polymorphic (CGG)nrepeat sequence, and cytogenetically express the folate-sensitive fragile site FRAXA in Xq27.3.	Folic Acid	182-188	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	212-217	
8651274-1	1996	The folate-sensitive fragile site FRAXE is located in proximal Xq28 of the human X chromosome and lies approximately 600 kb distal to the fragile X syndrome (FRAXA) fragile site at Xq27.3.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	158-163	
8673085-1	1996	Five folate-sensitive fragile sites have been characterized at the molecular level (FRAXA, FRAXE, FRAXF, FRA16A and FRA11B).	Folic Acid	5-11	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	84-89	
10222796-1	1999	The folate sensitive fragile site FRAXE is located in Xq28, 600 kb distal to the fragile X syndrome (FRAXA) fragile site.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	101-106	
10094554-1	1999	FRAXA, FRAXE, and FRAXF are folate-sensitive fragile sites originally discovered in patients with X-linked mental retardation.	Folic Acid	28-34	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	0-5	
8918933-1	1996	The rare folate-sensitive, fragile sites on chromsomes X, 11, and 16 contain blocks of CCG triplet repeats and large expansions of the CCG block at the FRAXA site produce the fragile X syndrome (FraX).	Folic Acid	9-15	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	152-157	
34681027-2	2021	These disorders are named for FRAXA, the folate-sensitive fragile site that localizes with the CGG-repeat in individuals with FXS.	Folic Acid	41-47	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	30-35	
8490650-1	1993	The vast majority of patients with fragile X syndrome show a folate-sensitive fragile site at Xq27.3 (FRAXA) at the cytogenetic level, and both amplification of the (CGG)n repeat and hypermethylation of the CpG island in the 5" fragile X gene (FMR-1) at the molecular level.	Folic Acid	61-67	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	102-107	
1619631-8	1992	A further two families had consistent expression of a different folate sensitive fragile site, FRAXE, close to FRAXA but not associated with fragile X syndrome and not detectable with the pfxa3 probe.	Folic Acid	64-70	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	111-116	
34567068-8	2021	The folate-sensitive FSs include FRAXA that is associated with Fragile X syndrome (FXS), the most common heritable form of intellectual disability.	Folic Acid	4-10	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	33-38	
34567068-10	2021	Recent work suggests that both APH-inducible fragile sites and FRAXA undergo Mitotic DNA synthesis (MiDAS) when exposed to APH or folate stress, respectively.	Folic Acid	130-136	fragile site, folic acid type, rare, fra(X)(q27.3) A (macroorchidism, mental retardation)	Homo sapiens	63-68