PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17519396-1	2007	The folic acid analog methotrexate (MTX), a competitive inhibitor of dihydrofolate reductase (DHFR), is used to treat a variety of cancers and autoimmune disorders.	Folic Acid	4-14	Dihydrofolate reductase	Drosophila melanogaster	69-92	
17519396-1	2007	The folic acid analog methotrexate (MTX), a competitive inhibitor of dihydrofolate reductase (DHFR), is used to treat a variety of cancers and autoimmune disorders.	Folic Acid	4-14	Dihydrofolate reductase	Drosophila melanogaster	94-98	
2124130-3	1990	Drosophila melanogaster DHFR can use folate and NADH at acidic pH values, but at a much lower rate than the preferred substrate and cofactor.	Folic Acid	37-43	Dihydrofolate reductase	Drosophila melanogaster	24-28	
2124130-4	1990	Folic acid is a partial competitive inhibitor of Drosophila DHFR (Ki = 0.4 microM) and trimethoprim is a complete competitive inhibitor (Ki = 5.4 microM).	Folic Acid	0-10	Dihydrofolate reductase	Drosophila melanogaster	60-64	
16280378-1	2006	Methotrexate (MTX), a synthetic folate analog, is a tight-binding inhibitor of dihydrofolate reductase (DHFR), a key enzyme for the biosynthesis of purines, thymidylate, and several amino acids.	Folic Acid	32-38	Dihydrofolate reductase	Drosophila melanogaster	79-102	
16280378-1	2006	Methotrexate (MTX), a synthetic folate analog, is a tight-binding inhibitor of dihydrofolate reductase (DHFR), a key enzyme for the biosynthesis of purines, thymidylate, and several amino acids.	Folic Acid	32-38	Dihydrofolate reductase	Drosophila melanogaster	104-108