PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21157027-3 2011 In the current study, we assessed the molecular mechanisms, mainly the modifications in the activity of mitochondrial complexes, whereby the association of folic acid and alpha-tocopherol protects mice against the Abeta-induced neurotoxicity. Folic Acid 156-166 amyloid beta (A4) precursor protein Mus musculus 214-219 27618097-0 2016 Effects of Folic Acid on Secretases Involved in Abeta Deposition in APP/PS1 Mice. Folic Acid 11-21 amyloid beta (A4) precursor protein Mus musculus 48-53 20624932-3 2010 Here, we report a novel function of glutamate carboxypeptidase II (GCPII) in Abeta degradation in brain, which is a peptidase involved in N-acetylaspartylglutamate cleavage, folate metabolism, and prostate tumorigenesis. Folic Acid 174-180 amyloid beta (A4) precursor protein Mus musculus 77-82 20164552-1 2010 Folic acid deficiency and hyperhomocysteinemia potentiate amyloid-beta (Abeta) neuron toxicity. Folic Acid 0-10 amyloid beta (A4) precursor protein Mus musculus 72-77 20164552-3 2010 We propose that folic acid might have a synergistic effect for memantine in protecting neurons from Abeta accumulation. Folic Acid 16-26 amyloid beta (A4) precursor protein Mus musculus 100-105 17504266-0 2007 Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine. Folic Acid 0-6 amyloid beta (A4) precursor protein Mus musculus 82-87 17504266-3 2007 We demonstrate herein that dietary deficiency in folate and vitamin E, coupled pro-oxidant stress induced by dietary iron, increased presenilin-1 expression, gamma-secretase activity, and Abeta levels in normal adult mice. Folic Acid 49-55 amyloid beta (A4) precursor protein Mus musculus 188-193 11880504-5 2002 When maintained on a folic acid-deficient diet, amyloid precursor protein (APP) mutant transgenic mice, but not wild-type mice, exhibited increased cellular DNA damage and hippocampal neurodegeneration. Folic Acid 21-31 amyloid beta (A4) precursor protein Mus musculus 48-73 11880504-7 2002 Our data suggest that folic acid deficiency and homocysteine impair DNA repair in neurons, which sensitizes them to oxidative damage induced by Abeta. Folic Acid 22-32 amyloid beta (A4) precursor protein Mus musculus 144-149 29865064-7 2018 The incremental AbetaPP phosphorylation at Thr668 mediated by severe genetic-or diet-induced impairment of the folate cycle correlates with enhanced accumulation of demethylated protein phosphatase 2A (PP2A), and activation of glycogen synthase kinase-3beta (GSK-3beta). Folic Acid 111-117 amyloid beta (A4) precursor protein Mus musculus 16-23 29865064-8 2018 Lastly, we show that severe disturbances in folate metabolism can also affect AbetaPP expression levels in a brain region specific manner. Folic Acid 44-50 amyloid beta (A4) precursor protein Mus musculus 78-85 29865064-10 2018 Deregulation of AbetaPP provides a novel mechanism by which common human MTHFR polymorphisms may interact with dietary folate deficiency to alter neuronal homeostasis and increase the risk for sporadic AD. Folic Acid 119-125 amyloid beta (A4) precursor protein Mus musculus 16-23 27618097-4 2016 Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid. Folic Acid 32-38 amyloid beta (A4) precursor protein Mus musculus 59-64 27618097-4 2016 Previous studies indicated that folate deficiency elevated Abeta deposition in APP/PS1 mice, and this rise was prevented by folic acid. Folic Acid 124-134 amyloid beta (A4) precursor protein Mus musculus 59-64 27618097-5 2016 In the present study, we aimed to investigate whether folic acid could influence the generation of Abeta by regulating alpha-, beta-, and gamma-secretase. Folic Acid 54-64 amyloid beta (A4) precursor protein Mus musculus 99-104 27618097-10 2016 Taken together, the effect of folic acid on Abeta deposition may relate to making APP metabolism through non-amyloidogenic pathway by decreasing beta-secretase and increasing alpha-secretase. Folic Acid 30-40 amyloid beta (A4) precursor protein Mus musculus 44-49 26345540-4 2015 We aimed to find if folic acid deficiency may enhance amyloid-beta (Abeta) peptide deposition and regulate amyloid-associated miRNAs and their target genes expression in APP/PS1 mice. Folic Acid 20-30 amyloid beta (A4) precursor protein Mus musculus 68-73 26224648-3 2016 We hypothesized that folic acid supplementation may protect neuron cells from amyloid beta (Abeta) oligomer-induced toxicity by modulating DNA methylation of APP and PS1 in AD models. Folic Acid 21-31 amyloid beta (A4) precursor protein Mus musculus 92-97 26224648-10 2016 CONCLUSION: These results suggest a mechanism by which folic acid may prevent Abeta oligomer-induced neuronal toxicity. Folic Acid 55-65 amyloid beta (A4) precursor protein Mus musculus 78-83 26345540-15 2015 In conclusion, folic acid deficiency can enhance Abeta accumulation in APP/PS1 mice brain and decrease amyloid-associated miRNAs expression. Folic Acid 15-25 amyloid beta (A4) precursor protein Mus musculus 49-54 26492244-3 2015 We hypothesized that folic acid supplementation modulates DNA methyltransferase (DNMT) activity and may alter amyloid beta-peptide (Abeta) production in AD. Folic Acid 21-31 amyloid beta (A4) precursor protein Mus musculus 132-137 26492244-7 2015 Furthermore, folic acid decreased Abeta protein production, whereas inhibition of DNMT activity by zebularine increased Abeta production. Folic Acid 13-23 amyloid beta (A4) precursor protein Mus musculus 34-39 26492244-8 2015 The results indicate that folic acid induces methylation potential-dependent DNMT enzymes, thereby attenuating Abeta production. Folic Acid 26-36 amyloid beta (A4) precursor protein Mus musculus 111-116 25959374-3 2015 We hypothesized that folic acid acts through an epigenetic gene silencing mechanism to lower Abeta levels in the APP/PS1 transgenic mouse model of AD. Folic Acid 21-31 amyloid beta (A4) precursor protein Mus musculus 93-98 25959374-3 2015 We hypothesized that folic acid acts through an epigenetic gene silencing mechanism to lower Abeta levels in the APP/PS1 transgenic mouse model of AD. Folic Acid 21-31 amyloid beta (A4) precursor protein Mus musculus 113-120 25959374-9 2015 Folate deficiency elevated hippocampal APP, PS1 and Abeta protein levels, and these rises were prevented by folic acid. Folic Acid 108-118 amyloid beta (A4) precursor protein Mus musculus 52-57 25959374-10 2015 In conclusion, these findings are consistent with a mechanism in which folic acid increases methylation potential and DNMT activity, modifies DNA methylation and ultimately decreases APP, PS1 and Abeta protein levels. Folic Acid 71-81 amyloid beta (A4) precursor protein Mus musculus 196-201