PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24558445-4 2014 In a separate group, animals were treated orally with folic acid (FA), which is known to recouple eNOS through augmentation of dihydrofolate reductase (DHFR) function. Folic Acid 54-64 dihydrofolate reductase Mus musculus 127-150 30502384-7 2019 Notably, overexpression of dihydrofolate reductase (DHFR) or exogenous addition of folate markedly reversed the astrocytes toxicity induced by MTX through activating folate metabolism pathway. Folic Acid 34-40 dihydrofolate reductase Mus musculus 52-56 2909524-1 1989 5,10-Dideazatetrahydrofolate (DDATHF) is a new antimetabolite designed as an inhibitor of folate metabolism at sites other than dihydrofolate reductase. Folic Acid 22-28 dihydrofolate reductase Mus musculus 128-151 3016548-1 1986 Methotrexate, a folate antagonist, blocks import into mitochondria of mouse dihydrofolate reductase fused to a mitochondrial presequence. Folic Acid 16-22 dihydrofolate reductase Mus musculus 76-99 6189586-8 1983 These findings support a role for dihydrofolate reductase as a locus for competitive binding interactions between reduced folates and methotrexate that may be a basis for the ability of 5-formyltetrahydrofolate to prevent the biochemical effects of this antifolate. Folic Acid 122-129 dihydrofolate reductase Mus musculus 34-57 33126053-0 2021 Targeting feed-forward signaling of TGFbeta/NOX4/DHFR/eNOS uncoupling/TGFbeta axis with anti-TGFbeta and folic acid attenuates formation of aortic aneurysms: Novel mechanisms and therapeutics. Folic Acid 105-115 dihydrofolate reductase Mus musculus 49-53 33126053-4 2021 Intriguingly, oral administration with folic acid (FA) to recouple eNOS markedly alleviated expansion of aortic roots and abdominal aortas in Fbn1C1039G/+ mice, which was attributed to substantially upregulated DHFR expression and activity in the endothelium to restore tissue and circulating levels of H4B. Folic Acid 39-49 dihydrofolate reductase Mus musculus 211-215 26830229-1 2016 Dihydrofolate reductase (DHFR) is a critical enzyme in the folate metabolism pathway and also plays a role in regulating nitric oxide (NO) signaling in endothelial cells. Folic Acid 7-13 dihydrofolate reductase Mus musculus 25-29 24558445-4 2014 In a separate group, animals were treated orally with folic acid (FA), which is known to recouple eNOS through augmentation of dihydrofolate reductase (DHFR) function. Folic Acid 54-64 dihydrofolate reductase Mus musculus 152-156 21550412-4 2011 In addition to key roles in folate metabolism, dihydrofolate reductase (DHFR) can "recycle" BH2, and thus regenerate BH4. Folic Acid 28-34 dihydrofolate reductase Mus musculus 47-70 22891343-10 2012 PPMO directed against T. gondii"s dihydrofolate reductase (DHFR), an enzyme necessary for folate synthesis, limited tachyzoite replication. Folic Acid 41-47 dihydrofolate reductase Mus musculus 59-63 22891343-11 2012 Rescue with exogenous folate demonstrated DHFR PPMO"s specificity. Folic Acid 22-28 dihydrofolate reductase Mus musculus 42-46 22083158-10 2012 Intriguingly, restoration of dihydrofolate reductase expression by oral administration of folic acid or overexpression of dihydrofolate reductase completely prevented AAA formation in Ang II-infused hph-1 mice while attenuating progressive uncoupling of eNOS. Folic Acid 90-100 dihydrofolate reductase Mus musculus 29-52 22549734-11 2012 Overexpression of Dhfr, or oral administration of folic acid to improve dihydrofolate reductase (DHFR) function, recoupled eNOS in diabetes to improve endothelial function. Folic Acid 50-60 dihydrofolate reductase Mus musculus 72-95 22549734-11 2012 Overexpression of Dhfr, or oral administration of folic acid to improve dihydrofolate reductase (DHFR) function, recoupled eNOS in diabetes to improve endothelial function. Folic Acid 50-60 dihydrofolate reductase Mus musculus 97-101 21550412-4 2011 In addition to key roles in folate metabolism, dihydrofolate reductase (DHFR) can "recycle" BH2, and thus regenerate BH4. Folic Acid 28-34 dihydrofolate reductase Mus musculus 72-76 7728929-5 1995 These findings suggest that the alpha-carboxyl group plays an important role in effective uptake via the reduced folate carrier, and a novel DHFR inhibitor could be obtained by chemically modifying the gamma-carboxyl moiety while leaving the alpha-carboxyl group intact. Folic Acid 113-119 dihydrofolate reductase Mus musculus 141-145 19660467-0 2009 Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. Folic Acid 26-36 dihydrofolate reductase Mus musculus 68-91 19660467-0 2009 Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. Folic Acid 26-36 dihydrofolate reductase Mus musculus 93-97 19660467-0 2009 Mechanistic insights into folic acid-dependent vascular protection: dihydrofolate reductase (DHFR)-mediated reduction in oxidant stress in endothelial cells and angiotensin II-infused mice: a novel HPLC-based fluorescent assay for DHFR activity. Folic Acid 26-36 dihydrofolate reductase Mus musculus 231-235 19660467-3 2009 Expression of dihydrofolate reductase (DHFR) was markedly increased by folic acid (FA, 50 micromol/L, 24 h) treatment in endothelial cells. Folic Acid 71-81 dihydrofolate reductase Mus musculus 14-37 19660467-3 2009 Expression of dihydrofolate reductase (DHFR) was markedly increased by folic acid (FA, 50 micromol/L, 24 h) treatment in endothelial cells. Folic Acid 71-81 dihydrofolate reductase Mus musculus 39-43 19110071-2 2009 The basis for its therapeutic efficacy is the inhibition of dihydrofolate reductase (DHFR), a key enzyme in the folic acid (FA) metabolism. Folic Acid 112-122 dihydrofolate reductase Mus musculus 60-83 19110071-2 2009 The basis for its therapeutic efficacy is the inhibition of dihydrofolate reductase (DHFR), a key enzyme in the folic acid (FA) metabolism. Folic Acid 112-122 dihydrofolate reductase Mus musculus 85-89 8934221-0 1996 The hematological effects of folate analogs: implications for using the dihydrofolate reductase gene for in vivo selection. Folic Acid 29-35 dihydrofolate reductase Mus musculus 72-95 1533575-4 1992 The increase of the mFBP expression, besides ensuring the growth of resistant cells by its contribution to the reduced folate intake, also participates in the methotrexate resistance by the internalization of folate cofactor which would compete with methotrexate hindering the effective inhibition of dihydrofolate reductase by the antifolate. Folic Acid 119-125 dihydrofolate reductase Mus musculus 301-324 35139535-9 2022 Finally, folic acid (FA) significantly attenuated aortic valve calcification in WD-fed Apoe-/- mice through increasing DHFR and salvaging BH4 biosynthesis. Folic Acid 9-19 dihydrofolate reductase Mus musculus 119-123