PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2633609-1	1989	Growth of rat hepatoma cells in subtoxic concentrations of the DHFR inhibitor metoprine caused a marked time and concentration dependent reduction in cellular folates.	Folic Acid	159-166	dihydrofolate reductase	Rattus norvegicus	63-67	
3676170-11	1986	The hepatic activity of another key folate-metabolizing enzyme, dihydrofolate reductase (EC 1.5.1.3), was not diminished by riboflavin deficiency in the present study.	Folic Acid	36-42	dihydrofolate reductase	Rattus norvegicus	64-87	
3630970-0	1987	Competitive inhibition of folate absorption by dihydrofolate reductase inhibitors, trimethoprim and pyrimethamine.	Folic Acid	26-32	dihydrofolate reductase	Rattus norvegicus	47-70	
3630970-5	1987	[3H] folic acid absorption from jejunal loops was determined 3-16 h after IV administration of methotrexate; this treatment abolished DHFR activity in the small intestine.	Folic Acid	5-15	dihydrofolate reductase	Rattus norvegicus	134-138	
29390203-9	2019	However, all of the above and hemodynamic index (RI) of femoral artery were resumed via restoration of DHFR protein expression by folic acid treatment or DHFR transfection.	Folic Acid	130-140	dihydrofolate reductase	Rattus norvegicus	103-107	
761221-5	1979	The presence of DHFR in neoplasms of central nervous system origin is relevant to the development of folate antagonists which, unlike methotrexate, can readily cross the blood-brain barrier.	Folic Acid	101-107	dihydrofolate reductase	Rattus norvegicus	16-20	
9701044-1	1997	A stretch of about 150 amino acids located between the heme and the calmodulin recognition sequence of nitric oxide synthase (NOS) has been strongly conserved within isoforms and was proposed to participate in pteridine binding because of sequence similarities to the folate binding site of dihydrofolate reductase (DHFR).	Folic Acid	268-274	dihydrofolate reductase	Rattus norvegicus	291-314	
9701044-1	1997	A stretch of about 150 amino acids located between the heme and the calmodulin recognition sequence of nitric oxide synthase (NOS) has been strongly conserved within isoforms and was proposed to participate in pteridine binding because of sequence similarities to the folate binding site of dihydrofolate reductase (DHFR).	Folic Acid	268-274	dihydrofolate reductase	Rattus norvegicus	316-320