PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	ATP binding cassette subfamily C member 3	Homo sapiens	68-73	
31223065-8	2019	A high tumoral expression of the genes SLC46A1/PCFT, SLC19A1/RFC-1, ABCC3/MRP3, GGH, and MTHFD1L, which are involved in folate transport, polyglutamation, or metabolism, was associated with longer disease-free survival of the patients.	Folic Acid	120-126	ATP binding cassette subfamily C member 3	Homo sapiens	74-78	
12628490-9	2003	These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated.	Folic Acid	104-110	ATP binding cassette subfamily C member 3	Homo sapiens	64-68	
12628490-0	2003	The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis.	Folic Acid	74-80	ATP binding cassette subfamily C member 3	Homo sapiens	57-61	
12628490-3	2003	In MRP1, MRP2 and MRP3-transfected 2008 human ovarian carcinoma cells total cellular folate content was 32-38% lower than in 2008 cells (105+/-14pmolfolate/mgprotein) when grown in medium containing 2.3 microM folic acid (FA).	Folic Acid	85-91	ATP binding cassette subfamily C member 3	Homo sapiens	18-22	
12628490-3	2003	In MRP1, MRP2 and MRP3-transfected 2008 human ovarian carcinoma cells total cellular folate content was 32-38% lower than in 2008 cells (105+/-14pmolfolate/mgprotein) when grown in medium containing 2.3 microM folic acid (FA).	Folic Acid	210-220	ATP binding cassette subfamily C member 3	Homo sapiens	18-22	
12628490-5	2003	However, when cells were challenged under folate-depleted conditions with a short exposure (4 hr) to FA or leucovorin, MRP1 and MRP3 overexpressing cells were impaired in their growth.	Folic Acid	42-48	ATP binding cassette subfamily C member 3	Homo sapiens	128-132	
12628490-9	2003	These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated.	Folic Acid	186-193	ATP binding cassette subfamily C member 3	Homo sapiens	64-68	
11585759-4	2001	Here we examine the role of MRP3 in these and related processes by determining the selectivity of this transporter for MTX, MTX polyglutamates, and physiological folates.	Folic Acid	162-169	ATP binding cassette subfamily C member 3	Homo sapiens	28-32	
11585759-5	2001	In so doing, we show that MRP3 is not only active in the transport of MTX but is also active in the transport the physiological folates folic acid (FA) and N(5)-formyltetrahydrofolic acid (leucovorin) and that polyglutamylation of MTX abolishes transport.	Folic Acid	128-135	ATP binding cassette subfamily C member 3	Homo sapiens	26-30	
11585759-5	2001	In so doing, we show that MRP3 is not only active in the transport of MTX but is also active in the transport the physiological folates folic acid (FA) and N(5)-formyltetrahydrofolic acid (leucovorin) and that polyglutamylation of MTX abolishes transport.	Folic Acid	136-146	ATP binding cassette subfamily C member 3	Homo sapiens	26-30	
11585759-10	2001	The capacity of MRP3 to transport folates indicates that it may reduce intracellular levels of these compounds and thereby indirectly influence antifolate cytotoxicity, and it also implies that this pump may play a role in the response to chemotherapeutic regimens in which leucovorin is a component.	Folic Acid	34-41	ATP binding cassette subfamily C member 3	Homo sapiens	16-20