PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15514969-2 2005 We conducted a study to examine associations between polymorphisms in folate pathway coenzymes (methylenetetrahydrofolate reductase [MTHFR] and methionine synthase [MS]) and cervical intraepithelial neoplasia (CIN) 2 or 3 in a population exposed to folic acid by the food fortification program in the United States. Folic Acid 70-76 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 144-163 15782407-2 2005 Vitamin B(12) (as methylcobalamin) is a cofactor for methionine synthase, an enzyme that plays a key role in folate metabolism. Folic Acid 109-115 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 53-72 14717604-1 2004 Human methionine synthase reductase (MSR) is a key enzyme in folate and methionine metabolism as it reactivates the catalytically inert cob(II)alamin form of methionine synthase (MS). Folic Acid 61-67 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 6-25 15117811-12 2004 Our results strongly suggest that polymorphisms of the MTHFR and MS genes act together with low folate intake and smoking to increase bladder cancer risk. Folic Acid 96-102 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 65-67 15218538-9 2004 The reactions that remove homocysteine are very sensitive to B vitamin status as both the transsulfuration enzymes contain pyridoxal phosphate, while methionine synthase contains cobalamin and receives its methyl group from the folic acid one-carbon pool. Folic Acid 228-238 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 150-169 11584084-8 2001 The subjects carrying the G2756 allele of the MS gene (n = 15) had a more extensive reduction (P < 0.05) of plasma tHcy during the high folate diet period than the subjects with the genotype A/A (n = 22). Folic Acid 139-145 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 46-48 12670934-1 2003 Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase. Folic Acid 22-32 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 185-204 12670934-1 2003 Vitamins B12, B6, and folic acid converge at the homocysteine metabolic junction where they support the activities of two key enzymes involved in intracellular homocysteine management, methionine synthase (MS) and cystathionine beta-synthase. Folic Acid 22-32 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 206-208 12751548-1 2003 Nitrous oxide interacts with vitamin B12 resulting in selective inhibition of methionine synthase, a key enzyme in methionine and folate metabolism. Folic Acid 130-136 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 78-97 12416982-2 2002 This reaction is of paramount physiological importance since methionine synthase is an essential enzyme that plays a key role in the methionine and folate cycles. Folic Acid 148-154 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 61-80 12021520-2 2002 methylcobalamin (Me-Cbl), the coenzymatically active form of vitamin B12 that acts as a cofactor for methionine synthase in the conversion of total homocysteine (tHcy) to methionine, with or without oral folic acid (FA) supplementation, on fasting tHcy levels in hemodialysis (HD) patients. Folic Acid 204-214 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 101-120 12111380-3 2002 Furthermore, several studies have suggested that a defective methionine synthase ( MS) enzyme could be a critical defect in folate-related NTDs. Folic Acid 124-130 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 61-80 12111380-3 2002 Furthermore, several studies have suggested that a defective methionine synthase ( MS) enzyme could be a critical defect in folate-related NTDs. Folic Acid 124-130 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 83-85 14564626-7 2003 Methylene-tetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are the enzymes involved in folate metabolism and are thought to influence DNA methylation. Folic Acid 20-26 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 49-68 11257268-0 2001 Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction. Folic Acid 83-89 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 15-34 11371572-2 2001 Cobalamin (vitamin B(12)) is structurally similar to heme and is a cofactor for methionine synthase, a key enzyme in folate metabolism. Folic Acid 117-123 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 80-99 11371572-6 2001 The inhibition of methionine synthase activity disrupted carbon flow through the folate pathway as measured by decreased incorporation of [(14)C]formate into methionine, serine, and purine nucleotides. Folic Acid 81-87 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 18-37 11509098-2 2001 Increasing evidence suggests that the beneficial effect of folate may be related to improved function of methionine synthase, a vitamin B12-dependent enzyme that converts homocysteine to methionine. Folic Acid 59-65 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 105-124 11295154-2 2001 This activity is compromised when Vitamin B12 (B12) concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM) which in turn may diminish DNA methylation and cause folate to become unavailable for the conversion of dUMP to dTMP. Folic Acid 233-239 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 81-100 11257268-1 2001 Methionine synthase (MS) encodes an enzyme that catalyzes the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate, which is the major circulating form of folate in the body. Folic Acid 156-162 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 11257268-1 2001 Methionine synthase (MS) encodes an enzyme that catalyzes the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetrahydrofolate, which is the major circulating form of folate in the body. Folic Acid 156-162 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 21-23 11257268-2 2001 Functional genetic variants of the MS may alter total homocysteine (tHcy) as well as folate levels which are independent risk factors for vascular disease. Folic Acid 85-91 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 35-37 11257268-3 2001 The influence of a common genetic polymorphism (2756A-->G, D919G) of the MS gene on plasma tHcy and folate levels and its relation to the risk of myocardial infarction (MI) in a prospective study of male physicians in the US was investigated. Folic Acid 103-109 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 76-78 11257268-8 2001 The MS polymorphism was associated with decreased tHcy (10.55, 9.87 and 9.57 nmol/ml for DD, DG and GG genotypes, respectively) and increased folate levels (3.95, 3.78, 7.31 ng/ml for DD, DG and GG genotypes, respectively) only among controls but not cases. Folic Acid 142-148 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 4-6 11257268-9 2001 It was concluded that influence of the MS (D919G) polymorphism on the plasma tHcy and folate levels is at most moderate, but should be further investigated in other large prospective studies. Folic Acid 86-92 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 39-41 11204591-9 2001 This interaction between CBS genotype and MTHFR and MS genotype points to a key role of the CBS transulphuration pathway in the metabolism of homocysteine that may be particularly important as a compensatory mechanism in subjects with low dietary folate. Folic Acid 247-253 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 52-54 11920232-2 2001 Several polymorphisms of genes encoding for enzymes acting in the remethylation pathway of homocysteine metabolism, ie, methionine synthase (MS) A2756G, methylenetetrahydrofolate reductase (MTHFR) C677T and MTHFR A1298C, can cause increased homocysteine levels particularly in patients with deficiencies of folic acid, vitamin B6, or B12 and hence be potential risk factors for VTE. Folic Acid 307-317 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 120-139 9316839-0 1997 Folate depletion induced by methotrexate affects methionine synthase activity and its susceptibility to inactivation by nitrous oxide. Folic Acid 0-6 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 49-68 11074217-2 2000 We therefore investigated the association between recurrent cardiovascular events and a mutation in methionine synthase (2756 A-->G)--an enzyme directly involved in folate and homocysteine metabolism. Folic Acid 168-174 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 100-119 10894832-2 2000 The four most common functional polymorphisms in genes involved in folate/homocysteine metabolism are methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MS) A2756G, and cystathionine beta-synthase (CBS) 844ins68. Folic Acid 67-73 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 164-183 10498402-0 1999 A polymorphism of the methionine synthase gene: association with plasma folate, vitamin B12, homocyst(e)ine, and colorectal cancer risk. Folic Acid 72-78 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 22-41 10498402-2 1999 In this study, we examined the relationship of a polymorphism (2756A-->G, asp-->gly) in the gene (MTR) for methionine synthase, another important enzyme in the same folate/methionine/homocyst(e)ine metabolic pathway, with risk of colorectal cancer among 356 cases and 476 cancer-free controls. Folic Acid 171-177 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 113-132 19094252-5 1998 In particular, folate is required for methylene reductase, pyridoxal phosphate for cystathionine synthase and cobalamin for methionine synthase. Folic Acid 15-21 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 124-143 9501215-4 1998 Patients of the cblE complementation group of disorders of folate/cobalamin metabolism who are defective in reductive activation of methionine synthase exhibit megaloblastic anemia, developmental delay, hyperhomocysteinemia, and hypomethioninemia. Folic Acid 59-65 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 132-151 1602376-4 1992 When cultured in a standard medium with high content (2.3 microM) of folic acid, the methionine synthase of all cell types was inactivated at an initial rate of 0.05 to 0.14 h-1. Folic Acid 69-79 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 85-104 8968737-0 1996 Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders. Folic Acid 121-127 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 6-25 8598561-10 1996 If methionine synthase is the critical enzyme, it would raise the interesting public health issue that vitamin B-12 might be able to stimulate the abnormal enzyme as folic acid does. Folic Acid 166-176 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 3-22 7741859-3 1995 We considered whether homocysteine metabolism via the enzyme methionine synthase, which requires both folate and B12, could be the critical defect in folate-related neural tube defects. Folic Acid 102-108 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 61-80 8005024-3 1994 The folate cofactor, N5-methyltetrahydrofolate, donates its methyl group to a vitamin B12-dependent enzyme, methionine synthase, which recycles homocysteine back to methionine. Folic Acid 4-10 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 108-127 8904527-4 1996 Methionine synthase converts cellular homocysteine to methionine and is a major enzyme in the biosynthetic pathways for folates, S-adenosylmethionine and biological methylations, sulphur amino acids and polyamines. Folic Acid 120-127 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 34799699-2 2021 The most abundant circulating folate species is 5-methyl tetrahydrofolate (5-methyl-THF), which is used to synthesize methionine from homocysteine via the cobalamin-dependent enzyme methionine synthase (MTR). Folic Acid 30-36 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 182-201 2407589-6 1990 Because inhibition of mammalian methionine synthase can restrict the incorporation of methyltetrahydrofolate from the blood into cellular folate pools that can be used for nucleotide biosynthesis, it is a potential chemotherapeutic target. Folic Acid 102-108 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 32-51 34799701-0 2021 Methionine synthase is essential for cancer cell proliferation in physiological folate environments. Folic Acid 80-86 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 34799701-3 2021 We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source. Folic Acid 37-43 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 77-96 34799701-3 2021 We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source. Folic Acid 206-212 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 77-96 34799701-3 2021 We find that the enzyme that couples folate and methionine metabolic cycles, methionine synthase, is required for cancer cell proliferation and tumour growth when 5-methyl tetrahydrofolate (THF), the major folate found in circulation, is the extracellular folate source. Folic Acid 256-262 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 77-96 34799701-4 2021 In such physiological conditions, methionine synthase incorporates 5-methyl THF into the folate cycle to maintain intracellular levels of the folates needed for nucleotide production. Folic Acid 89-95 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 34-53 34799701-4 2021 In such physiological conditions, methionine synthase incorporates 5-methyl THF into the folate cycle to maintain intracellular levels of the folates needed for nucleotide production. Folic Acid 142-149 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 34-53 33179601-5 2020 The re-methylation reaction not only involves the enzymes methionine synthase and methionine synthase reductase but also depends on the cofactor cobalamin and on the provision of methyl groups from the folate cycle. Folic Acid 202-208 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 58-77 2671982-6 1989 Methionine synthase in P. falciparum may play a role in the supply of methionine and in folate salvage using exogenous 5-CH3-H4PteGlu for tetrahydrofolate metabolism. Folic Acid 88-94 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 32353563-1 2020 In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase. Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 21-40 32353563-1 2020 In eucaryotic cells, methionine synthase reductase (MSR/MTRR) is capable of dominating the folate-homocysteine metabolism as an irreplaceable partner in electron transfer for regeneration of methionine synthase. Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 191-210 33274184-4 2020 We analyzed three functional folate gene variants, namely 5-methyltetrahydrofolate-homocysteine methyltransferase rs1805087, 5-methyltetrahydrofolate-homocysteine methyltransferase reductase rs1801394, and reduced folate carrier 1 rs1051266, for contribution in the etiology of DS. Folic Acid 29-35 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 58-113 30848279-2 2019 A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase. Folic Acid 58-64 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 123-142 30693532-5 2019 Disruption of methionine synthase has wide-ranging implications for all methylation-dependent reactions, including epigenetic modification, but also for the intracellular folate pathway, since methionine synthase uses 5-methyltetrahydrofolate as a one-carbon donor. Folic Acid 171-177 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 14-33 30693532-5 2019 Disruption of methionine synthase has wide-ranging implications for all methylation-dependent reactions, including epigenetic modification, but also for the intracellular folate pathway, since methionine synthase uses 5-methyltetrahydrofolate as a one-carbon donor. Folic Acid 171-177 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 193-212 30848279-2 2019 A key pathway of this metabolism is the vitamin B-12- and folate-dependent remethylation of homocysteine, which depends on methionine synthase (MS, encoded by MTR), methionine synthase reductase, and methylenetetrahydrofolate reductase. Folic Acid 58-64 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 144-146 30337500-1 2018 Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. Folic Acid 61-67 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 30228213-11 2018 5-Methyltetrahydrofolate, the main form of folate found in blood, is essential for the vitamin B12-dependent methionine synthase mediated remethylation of homocysteine to methionine. Folic Acid 18-24 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 87-128 30337500-1 2018 Methionine synthase (METH, i.e., MTR) is a key enzyme in the folate pathway, which plays a critical role in the synthesis, repair, and methylation of DNA. Folic Acid 61-67 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 21-25 26334892-2 2015 Besides, methionine synthase (MTR) gene and methionine synthase reductase (MTRR) gene were folate metabolism involved genes and had been investigated in several previous studies with inconsistent results. Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 9-28 29474406-10 2018 Irrespective of cancer status, several SNPs were found to be associated with altered serum folate concentrations, including the D919G SNP in methionine synthase (MTR), the L474F SNP in serine hydroxymethyl transferase 1 (SHMT1) and the V175M SNP in phosphatidyl ethanolamine methyltransferase (PEMT). Folic Acid 91-97 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 141-160 28537809-3 2017 Methionine synthase (MTR) and methionine synthase reductase (MTRR) are critical enzymes for the folate cycle. Folic Acid 96-102 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 28724269-1 2017 Methionine synthase (MTR) is one of the key enzymes of folate pathway, which play a key role in the construction, repair, and methylation of DNA. Folic Acid 55-61 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 26523551-1 2015 Methionine synthase (MTR) plays a crucial role in maintaining homeostasis of intracellular methionine, folate, and homocysteine, and its activity correlates with DNA methylation in many mammalian tissues. Folic Acid 103-109 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 30084801-3 2018 Methionine synthase (MTR), a key enzyme of folate metabolism, is involved in the early embryonic development. Folic Acid 43-49 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 28118645-1 2017 Polymorphisms in genes encoding the enzymes involved in the metabolism of homocysteine, such as methionine synthase (MTR) and methionine synthase reductase (MTRR), play an important function in the metabolism of folic acid and vitamin B12. Folic Acid 212-222 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 96-115 26595280-3 2015 The methionine synthase (MTR) gene plays key role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations and, its polymorphism have been associated with the risk of retinoblastoma and other neoplasms. Folic Acid 88-94 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 4-23 26299783-2 2015 Folate deficiency has been associated with placenta-related pregnancy complications, as have SNP in genes of the folate-dependent enzymes, methionine synthase (MTR) and methylenetetrahydrofolate dehydrogenase 1 (MTHFD1). Folic Acid 113-119 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 139-158 24559276-3 2014 The serine hydroxymethyhransferase (SHMT), methionine synthase (MS), methionine synthase reductase (MTRR) and cystathionine beta synthase (CBS) regulate key reactions in the folate and Hcy metabolism. Folic Acid 174-180 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 43-62 26154858-2 2015 The mammalian folic acid cycle is highly complex and the enzymes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR), have crucial roles in this metabolic pathway. Folic Acid 14-24 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 111-130 25544674-3 2015 We conducted a case-control study to explore polymorphisms of the major folate pathway genes, including methylenetetrahydrofolate reductase (MTHFR) 677C>T, MTHFR 1298A>C, methionine synthase (MTR) 2756A>G, methionine synthase reductase (MTRR) 66A>G and reduced folate carrier 1 (RFC-1) 80A>G, and their associations with URPL. Folic Acid 72-78 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 177-196 27928289-1 2014 Folic acid has a fundamental role in central nervous system (CNS) function at all ages, especially the methionine synthase-mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic Acid 0-10 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 103-122 23959833-3 2013 It is still controversial and ambiguous between the functional polymorphisms of folate metabolism genes 5,10-methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTRR), and methionine synthase reductase (MTR) and risk of adult meningioma. Folic Acid 80-86 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 154-173 23155246-3 2012 In this case control study, we examined the combination of the polymorphisms MTHFR C677T and A1298C with MTR A2756G, where MTR, methionine synthase, is an important enzyme of the folate cycle in the methylation pathway. Folic Acid 179-185 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 128-147 23593229-1 2013 Methionine synthase (MTR), which plays a central role in maintaining adequate intracellular folate, methionine and normal homocysteine concentrations, was thought to be involved in the development of colorectal cancer (CRC) and colorectal adenoma (CRA) by affecting DNA methylation. Folic Acid 92-98 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 23500531-8 2013 Moreover, they are important for the regulation of folate metabolites by using tetrahydrofolate as cosubstrate in choline degradation, reduction of N-5.10-methylenetetrahydrofolate to N-5-methyltetrahydrofolate and maintenance of the catalytically competent form of methionine synthase. Folic Acid 51-57 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 266-285 23613867-2 2013 Methionine synthase (MTR) plays a central role in folate metabolism, thereby affecting DNA methylation. Folic Acid 50-56 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 22956622-4 2012 PEE restored the Al-induced inhibition of folate-dependent methionine synthase activity and the antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). Folic Acid 42-48 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 59-78 22422209-5 2012 Pathways of cobalamin and folate metabolism intersect at one site, methionine synthase. Folic Acid 26-32 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 67-86 22093367-2 2012 This activity is compromised when vitamin B12 concentration is low because methionine synthase activity is reduced, lowering the concentration of S-adenosyl methionine (SAM) which in turn may diminish DNA methylation and cause folate to become unavailable for the conversion of dUMP to dTMP. Folic Acid 227-233 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 75-94 22097960-1 2011 Human methionine synthase reductase (MSR), a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase (MS) activity. Folic Acid 107-113 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 6-25 22230384-1 2012 BACKGROUND: This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults. Folic Acid 150-160 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 253-272 22022143-0 2011 Genetic interactions between MTHFR (C677T), methionine synthase (A2756G, C2758G) variants with vitamin B12 and folic acid determine susceptibility to premature coronary artery disease in Indian population. Folic Acid 111-121 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 44-63 19249419-2 2009 Many receive nitrous oxide, which impairs methionine synthase, thus inhibiting folate synthesis and increasing postoperative homocysteine levels. Folic Acid 79-85 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 42-61 21295329-2 2011 In vitro studies found that mercury inhibited methionine synthase, an enzyme that interacts with vitamin B-12 and folate to regenerate the amino acid methionine from homocysteine, and inhibition of methionine synthase diverted homocysteine to cysteine and glutathione synthesis. Folic Acid 114-120 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 46-65 19141696-7 2009 These interactions, which were not seen in NHANES III before fortification, imply that, in vitamin B-12 deficiency, high folate status is associated with impaired activity of the 2 vitamin B-12-dependent enzymes, methionine synthase and MMA-coenzyme A mutase. Folic Acid 121-127 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 213-258 19838916-1 2009 We investigated associations among intake of folate, vitamin B2, vitamin B6, vitamin B12, and polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR) genes and breast cancer risk in a Japanese population. Folic Acid 45-51 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 164-183 19124508-0 2009 Methionine synthase A2756G polymorphism interacts with alcohol and folate intake to influence the risk of colorectal adenoma. Folic Acid 67-73 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 18842806-6 2008 DESIGN: Thirteen single nucleotide polymorphisms (SNPs) in genes involved in folate uptake and metabolism, including folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), gamma-glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), methionine synthase (MTR), proton-coupled folate transporter (PCFT), and reduced folate carrier (RFC1), were studied in a cohort of 991 individuals. Folic Acid 77-83 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 259-278 18351371-2 2008 Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are critical enzymes of folate metabolic pathways. Folic Acid 19-25 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 69-71 18594211-1 2008 Cobalamin-dependent methionine synthase, with a cofactor of vitamin B12, catalyzes the reaction of 5-methyltetrahydrofolate and homocysteine to form methionine and tetrahydrofolate, which takes a core position in folate cycle, one-carbon-unit transfer, and sulfur amino acid pathways. Folic Acid 117-123 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-39 17726616-2 2008 Methionine synthase (MTR) and cystathionine ss-synthase (CBS) are enzymes that play a central role in folate metabolism, thereby affecting DNA methylation and synthesis. Folic Acid 102-108 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 18580170-9 2008 Plasma 5-methyl-tetrahydrofolate concentrations increased uniformly by 20% after nitrous oxide anesthesia, indicating the inactivation of methionine synthase and subsequent folate trapping. Folic Acid 26-32 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 138-157 18844488-2 2008 Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body. Folic Acid 169-175 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 18406541-2 2008 Genetic polymorphisms in folate pathway related enzymes including methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase (MTR) A2756G, thymidylate synthase (TS) 28-bp tandem repeat, and reduced folate carrier (RFC) G80A have been shown to be associated with increased susceptibility for several cancers. Folic Acid 25-31 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 128-147 18844488-2 2008 Methionine synthase (MS), a vitamin B(12)-dependent enzyme, catalyses the remethylation of homocysteine to methionine using a methyl group donated by 5-methyltetra-hydrofolate, which is the major circulating form of folate in the body. Folic Acid 169-175 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 21-23 18844488-3 2008 Functional genetic variants of the MS may alter tHcy as well as folate levels which are independent risk factors for CAD. Folic Acid 64-70 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 35-37 18844488-4 2008 The influence of a common genetic polymorphism 2756A>G of the MS gene (MTR) on plasma tHcy, folate and vitamin B(12) levels and its relation to the risk of myocardial infarction (MI) in a Tunisian case-control study was investigated. Folic Acid 95-101 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 65-67 17052662-2 2006 Folates and vitamin B12 have fundamental roles in CNS function at all ages, especially the methionine-synthase mediated conversion of homocysteine to methionine, which is essential for nucleotide synthesis and genomic and non-genomic methylation. Folic Acid 0-7 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 91-110 17087642-2 2006 The methionine synthase reductase (MTRR) enzyme restores methionine synthase (MTR) enzyme activity and therefore plays an essential role in the folate- and vitamin B(12)-dependent remethylation of homocysteine to methionine. Folic Acid 144-150 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 4-23 16142417-1 2005 The functional polymorphism methionine synthase (MTR) c.2576A-->G (D919G) influences homocysteine and folate metabolism and has been reported to be of protective function against oncological, neurodegenerative and vascular diseases. Folic Acid 105-111 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 28-47 17683808-1 2007 Methionine synthase is a key enzyme poised at the intersection of folate and sulfur metabolism and functions to reclaim homocysteine to the methionine cycle. Folic Acid 66-72 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 0-19 17574963-3 2007 Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MS) are enzymes that play central roles in the folate metabolic pathway. Folic Acid 19-25 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 48-67 16861746-1 2006 BACKGROUND: Three typical folate metabolism enzymes-i.e. methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MS) and MS reductase (MTRR) in the folate cycle-play a critical role in DNA synthesis and methylation reactions. Folic Acid 26-32 5-methyltetrahydrofolate-homocysteine methyltransferase Homo sapiens 102-121