PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14608078-5 2003 We examined the effect of folic acid supplementation for 6 wk and 12 mo (5 mg/d for 1 wk, 1 mg/d for 37 wk and 0.4 mg/d for the remaining 14 wk) on LOX-1 mRNA levels and on oxLDL-induced release of tumor necrosis factor alpha from peripheral blood mononuclear cells in hyperhomocysteinemic individuals. Folic Acid 26-36 oxidized low density lipoprotein receptor 1 Homo sapiens 148-153 14608078-8 2003 Folic acid treatment led to a normalization of homocysteine levels accompanied by a reduction in LOX-1 gene expression (P < 0.02) and in oxLDL-stimulated release of TNFalpha (P < 0.05). Folic Acid 0-10 oxidized low density lipoprotein receptor 1 Homo sapiens 97-102 14608078-9 2003 These novel findings suggest both that homocysteine exerts its atherogenic effect in part by elevating levels of LOX-1, thereby enhancing oxLDL-induced inflammatory responses, and most important, that folic acid supplementation may downregulate these responses. Folic Acid 201-211 oxidized low density lipoprotein receptor 1 Homo sapiens 113-118