PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30955184-8 2019 Folate was significantly positively associated with invasive and estrogen receptor-positive/progesterone receptor-positive breast cancer, and this association was suggestively stronger for bloods collected post-fortification. Folic Acid 0-6 estrogen receptor 1 Homo sapiens 65-82 32241696-8 2020 Further study showed that folate and vitamin B6 might decrease the risk of estrogen receptor-negative (ER-)/progesterone receptor-negative (PR-) breast cancer but not ER+/PR+ breast cancer. Folic Acid 26-32 estrogen receptor 1 Homo sapiens 75-92 23328702-2 2012 We determined whether supplementation with physiological doses of folate could alter methylation in the oestrogen receptor 1 (ESR1) and mutL homolog 1 (MLH1) genes in colonic mucosa of subjects with colorectal adenoma. Folic Acid 66-72 estrogen receptor 1 Homo sapiens 126-130 23893181-9 2013 For ER negative patients, only three pathways including the folate biosynthesis pathway were enriched with DEGs and none of them overlapped with those of ER positive patients. Folic Acid 60-66 estrogen receptor 1 Homo sapiens 4-6 28445960-8 2017 Folate deficiency significantly reduced the expression of ESR1, CAV1, and ELAVL1, which are critical to spermatogenesis. Folic Acid 0-6 estrogen receptor 1 Homo sapiens 58-62 23996837-7 2014 Our findings suggest that natural food folate intake is inversely associated with breast cancer risk and that this association may vary by race, menopausal status or ER status. Folic Acid 39-45 estrogen receptor 1 Homo sapiens 166-168 20711807-7 2010 The plasma levels of folate and vitamin B(12) were inversely related to the hypermethylation status of ERalpha, after controlling for covariates. Folic Acid 21-27 estrogen receptor 1 Homo sapiens 103-110 19116331-9 2009 CONCLUSIONS: Our study of predominantly supplement users suggests that high intakes of folate averaged over 10 y do not increase breast cancer risk, but may be protective, particularly against ER- breast cancers. Folic Acid 87-93 estrogen receptor 1 Homo sapiens 193-195 20698054-7 2010 Dietary vitamin E was associated with decreased risk of ER and PGR positive breast cancer (IRR: 0.50; 95% CI: 0.25-0.98) and dietary folate was associated with increased risk of ER and PGR positive breast cancer (IRR: 1.27; 95% CI: 1.03-1.95). Folic Acid 133-139 estrogen receptor 1 Homo sapiens 178-180 21088384-5 2010 RESULTS: After exposure to a high concentration of folic acid (20 mumol/l), enhanced cancer cell growth and concomitant increased methylation of the ESR1 (3.6-fold), p16(INK)4(a) and p15(INK)4(b) promoters was observed. Folic Acid 51-61 estrogen receptor 1 Homo sapiens 149-153 21149331-10 2010 Higher RBC folate levels were associated with higher levels of both ERalpha (P = 0.03) and SFRP1 methylation (P = 0.01). Folic Acid 11-17 estrogen receptor 1 Homo sapiens 68-75 16042580-0 2005 Methylation of the ESR1 CpG island in the colorectal mucosa is an "all or nothing" process in healthy human colon, and is accelerated by dietary folate supplementation in the mouse. Folic Acid 145-151 estrogen receptor 1 Homo sapiens 19-23 18326613-9 2008 However, higher plasma folate concentrations were moderately associated with an increased risk of developing premenopausal breast cancer (P for trend = 0.04) and for developing estrogen receptor (ER)-positive or progesterone receptor (PR)-positive breast tumors (P for trend < or = 0.06). Folic Acid 23-29 estrogen receptor 1 Homo sapiens 177-194 18326613-9 2008 However, higher plasma folate concentrations were moderately associated with an increased risk of developing premenopausal breast cancer (P for trend = 0.04) and for developing estrogen receptor (ER)-positive or progesterone receptor (PR)-positive breast tumors (P for trend < or = 0.06). Folic Acid 23-29 estrogen receptor 1 Homo sapiens 196-198 19064560-3 2008 We examined the association between dietary folate intake and the risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumor in the Swedish Mammography Cohort. Folic Acid 44-50 estrogen receptor 1 Homo sapiens 91-108 19064560-3 2008 We examined the association between dietary folate intake and the risk of breast cancer by estrogen receptor (ER) and progesterone receptor (PR) status of the breast tumor in the Swedish Mammography Cohort. Folic Acid 44-50 estrogen receptor 1 Homo sapiens 110-112 19064560-9 2008 However, folate intake was inversely associated with risk of ER+/PR- breast cancer (n = 417 cases; RR for highest versus lowest quintile, 0.79; 95% CI, 0.59-1.07; P(trend) = 0.01). Folic Acid 9-15 estrogen receptor 1 Homo sapiens 61-63 17921385-0 2007 Methylation of estrogen receptor alpha and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia. Folic Acid 101-107 estrogen receptor 1 Homo sapiens 15-38 17921385-2 2007 OBJECTIVE: We tested the hypothesis that biomarkers of folate and vitamin B-12 status are associated with estrogen receptor alpha (ERalpha) and mutL homolog 1 (MLH1) promoter methylation in subjects with and without neoplasia. Folic Acid 55-61 estrogen receptor 1 Homo sapiens 106-129 17921385-2 2007 OBJECTIVE: We tested the hypothesis that biomarkers of folate and vitamin B-12 status are associated with estrogen receptor alpha (ERalpha) and mutL homolog 1 (MLH1) promoter methylation in subjects with and without neoplasia. Folic Acid 55-61 estrogen receptor 1 Homo sapiens 131-138 16042580-6 2005 Preliminary studies with a rodent model suggest the rate of age-dependent methylation of ESR1 is modifiable by dietary folate. Folic Acid 119-125 estrogen receptor 1 Homo sapiens 89-93 16103452-2 2005 Thus, deficient folate status has been hypothesized to be associated primarily with ER gene-negative breast tumors, but data relating folate intake to breast cancer risk according to ER status are sparse. Folic Acid 16-22 estrogen receptor 1 Homo sapiens 84-86 16103452-5 2005 Higher total folate intake was significantly associated with lower risk of developing ER- but not ER+ breast cancer; the multivariable relative risks (RR) and 95% confidence intervals (95% CI) comparing the highest to the lowest quintile were 0.81 (0.66-0.99) for ER- tumors and 1.00 (0.89-1.14) for ER+ tumors. Folic Acid 13-19 estrogen receptor 1 Homo sapiens 86-88 16103452-6 2005 The inverse association between total folate intake and ER- breast cancer was mainly present among women consuming at least 15 g/d of alcohol (multivariable RR, 0.46; 95% CI,=0.25-0.86; top versus bottom quintile). Folic Acid 38-44 estrogen receptor 1 Homo sapiens 56-58 16103452-7 2005 These findings support the hypothesis that higher folate intake reduces the risk of developing ER- breast cancer. Folic Acid 50-56 estrogen receptor 1 Homo sapiens 95-97 12734059-11 2002 After adjustment for age, extent of disease, total calories, alcohol, and estrogen receptor status, women with total folate intake in the highest tertile had a mortality risk ratio of 0.88 (95% confidence interval = 0.44-1.76) compared with cases in the lowest tertile of folate. Folic Acid 117-123 estrogen receptor 1 Homo sapiens 74-91 14682440-9 2003 RESULTS: Our results showed that the odds ratio (OR) estimates for lower dietary folate intake were 2.0 (95% confidence interval, CI: 0.8-4.8) for cases with a methylated ER alpha gene, 0.6 (95% CI: 0.3-1.5) for cases with an unmethylated ER alpha gene, and 1.6 (95% CI: 0.7-3.8) for cases with unknown methylation status (presumably including cases with both methylated and un-methylated genes). Folic Acid 81-87 estrogen receptor 1 Homo sapiens 171-179 14682440-9 2003 RESULTS: Our results showed that the odds ratio (OR) estimates for lower dietary folate intake were 2.0 (95% confidence interval, CI: 0.8-4.8) for cases with a methylated ER alpha gene, 0.6 (95% CI: 0.3-1.5) for cases with an unmethylated ER alpha gene, and 1.6 (95% CI: 0.7-3.8) for cases with unknown methylation status (presumably including cases with both methylated and un-methylated genes). Folic Acid 81-87 estrogen receptor 1 Homo sapiens 239-247