PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28288183-9 2017 The highest user rate was observed for the substrates of multidrug resistance-associated protein 1, mainly folic acid (6% of cases, 8% of referents), and breast cancer resistance protein, mainly nitrofurantoin (2.3% of cases, 2.9% of referents). Folic Acid 107-117 ATP binding cassette subfamily C member 1 Homo sapiens 57-98 24595806-10 2014 In conclusion, this study demonstrates that increased cellular folate concentrations induce MRP1/ABCC1-related drug efflux and drug resistance. Folic Acid 63-69 ATP binding cassette subfamily C member 1 Homo sapiens 97-102 24595806-1 2014 Cellular folate concentration was earlier reported to be a critical factor in the activity and expression of the multidrug resistance protein MRP1 (ABCC1). Folic Acid 9-15 ATP binding cassette subfamily C member 1 Homo sapiens 148-153 19636555-10 2010 CONCLUSIONS: The expression level of FPGS, GGH and ABCC1 in CRC tissues could predict the reduced folate level after LV administration, and these factors may determine the efficacy of LV treatment. Folic Acid 98-104 ATP binding cassette subfamily C member 1 Homo sapiens 51-56 18691054-8 2008 In vitro, the MRP/ABCC transporters can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, arsenical and antimonial oxyanions, peptide-based agents, and in concert with alterations in phase II conjugating or biosynthetic enzymes, classical alkylating agents, alkylating agents. Folic Acid 161-167 ATP binding cassette subfamily C member 1 Homo sapiens 14-17 19240161-0 2009 Cellular folate status modulates the expression of BCRP and MRP multidrug transporters in cancer cell lines from different origins. Folic Acid 9-15 ATP binding cassette subfamily C member 1 Homo sapiens 60-63 18623116-2 2008 Our aim was to study the time-dependent effect of folate deprivation/supplementation on (i) BCRP and MRP expression and (ii) on drug resistance mediated by these transporters. Folic Acid 50-56 ATP binding cassette subfamily C member 1 Homo sapiens 101-104 18691054-8 2008 In vitro, the MRP/ABCC transporters can collectively confer resistance to natural product anticancer drugs and their conjugated metabolites, platinum compounds, folate antimetabolites, nucleoside and nucleotide analogs, arsenical and antimonial oxyanions, peptide-based agents, and in concert with alterations in phase II conjugating or biosynthetic enzymes, classical alkylating agents, alkylating agents. Folic Acid 161-167 ATP binding cassette subfamily C member 1 Homo sapiens 18-22 15657365-6 2005 Folate deprivation was also associated with a 3-fold decrease in BCRP and multidrug resistance protein 1 (MRP1/ABCC1) levels. Folic Acid 0-6 ATP binding cassette subfamily C member 1 Homo sapiens 106-110 16362298-8 2006 Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2. Folic Acid 56-63 ATP binding cassette subfamily C member 1 Homo sapiens 156-160 16362298-8 2006 Moreover, studies from our laboratory demonstrated that folates could modulate the expression and activity of at least two members of the MDR transporters: MRP1/ABCC1, and the breast cancer resistance protein BCRP/ABCG2. Folic Acid 56-63 ATP binding cassette subfamily C member 1 Homo sapiens 161-166 16362298-9 2006 Thus, folate supplementation may have differential effects on chemotherapy: (1) reduction of toxicity, (2) increase of antitumor activity, and (3) induction of MRP1 and BCRP associated cellular drug resistance. Folic Acid 6-12 ATP binding cassette subfamily C member 1 Homo sapiens 160-164 15657365-6 2005 Folate deprivation was also associated with a 3-fold decrease in BCRP and multidrug resistance protein 1 (MRP1/ABCC1) levels. Folic Acid 0-6 ATP binding cassette subfamily C member 1 Homo sapiens 111-116 15657365-9 2005 Hence, cellular adaptation to shortterm folate deprivation results in a selective confinement of BCRP to the cytoplasm along with a moderate decrease in BCRP and MRP1 levels aimed at preserving the poor intracellular folate pools. Folic Acid 40-46 ATP binding cassette subfamily C member 1 Homo sapiens 162-166 11585759-8 2001 We also show that polyglutamylation similarly affects the capacity of MRP1 to transport MTX and that physiological folates are also subject to MgATP-stimulated transport by MRP1. Folic Acid 115-122 ATP binding cassette subfamily C member 1 Homo sapiens 173-177 15041471-0 2004 Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Folic Acid 0-6 ATP binding cassette subfamily C member 1 Homo sapiens 89-94 15041471-2 2004 In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin. Folic Acid 60-67 ATP binding cassette subfamily C member 1 Homo sapiens 13-17 15041471-2 2004 In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin. Folic Acid 60-67 ATP binding cassette subfamily C member 1 Homo sapiens 18-23 15041471-2 2004 In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin. Folic Acid 77-87 ATP binding cassette subfamily C member 1 Homo sapiens 13-17 15041471-2 2004 In addition, MRP1/ABCC1 mediates cellular export of natural folates, such as folic acid and l-leucovorin. Folic Acid 77-87 ATP binding cassette subfamily C member 1 Homo sapiens 18-23 15041471-3 2004 In this study we determined whether cellular folate status affected the functional activity of MRP1/ABCC1 mediated efflux of an established substrate, the anthracycline daunorubicin (DNR). Folic Acid 45-51 ATP binding cassette subfamily C member 1 Homo sapiens 95-99 15041471-3 2004 In this study we determined whether cellular folate status affected the functional activity of MRP1/ABCC1 mediated efflux of an established substrate, the anthracycline daunorubicin (DNR). Folic Acid 45-51 ATP binding cassette subfamily C member 1 Homo sapiens 100-105 15041471-5 2004 Both types of these moderate- and high-MRP1/ABCC1 expressing cells displayed efflux of DNR when maintained in standard culture media (2.3microM folic acid). Folic Acid 144-154 ATP binding cassette subfamily C member 1 Homo sapiens 39-43 15041471-5 2004 Both types of these moderate- and high-MRP1/ABCC1 expressing cells displayed efflux of DNR when maintained in standard culture media (2.3microM folic acid). Folic Acid 144-154 ATP binding cassette subfamily C member 1 Homo sapiens 44-49 15041471-9 2004 When 2008/MRP1 cells were challenged for 2 days in folate-free medium, total cellular DNR efflux was decreased to 43% of the initial efflux rate under folate-rich conditions. Folic Acid 51-57 ATP binding cassette subfamily C member 1 Homo sapiens 10-14 15041471-9 2004 When 2008/MRP1 cells were challenged for 2 days in folate-free medium, total cellular DNR efflux was decreased to 43% of the initial efflux rate under folate-rich conditions. Folic Acid 151-157 ATP binding cassette subfamily C member 1 Homo sapiens 10-14 12628490-9 2003 These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated. Folic Acid 186-193 ATP binding cassette subfamily C member 1 Homo sapiens 54-58 15041471-14 2004 In conclusion, this study demonstrates that the cellular folate status can influence the transport activity of MRP1/ABCC1. Folic Acid 57-63 ATP binding cassette subfamily C member 1 Homo sapiens 111-115 15041471-14 2004 In conclusion, this study demonstrates that the cellular folate status can influence the transport activity of MRP1/ABCC1. Folic Acid 57-63 ATP binding cassette subfamily C member 1 Homo sapiens 116-121 15041471-15 2004 These results have potentially important implications in the understanding of the (patho-)physiological roles of MRP1/ABCC1, and possibly other ABC transporter proteins in cellular folate homeostasis and drug resistance. Folic Acid 181-187 ATP binding cassette subfamily C member 1 Homo sapiens 113-117 15041471-15 2004 These results have potentially important implications in the understanding of the (patho-)physiological roles of MRP1/ABCC1, and possibly other ABC transporter proteins in cellular folate homeostasis and drug resistance. Folic Acid 181-187 ATP binding cassette subfamily C member 1 Homo sapiens 118-123 12628490-0 2003 The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis. Folic Acid 74-80 ATP binding cassette subfamily C member 1 Homo sapiens 42-46 12628490-3 2003 In MRP1, MRP2 and MRP3-transfected 2008 human ovarian carcinoma cells total cellular folate content was 32-38% lower than in 2008 cells (105+/-14pmolfolate/mgprotein) when grown in medium containing 2.3 microM folic acid (FA). Folic Acid 85-91 ATP binding cassette subfamily C member 1 Homo sapiens 3-7 12628490-5 2003 However, when cells were challenged under folate-depleted conditions with a short exposure (4 hr) to FA or leucovorin, MRP1 and MRP3 overexpressing cells were impaired in their growth. Folic Acid 42-48 ATP binding cassette subfamily C member 1 Homo sapiens 119-123 12628490-9 2003 These results suggest that down- and up-regulation of MRP1 (and MRP3) expression can influence cellular folate homeostasis, in particular when cellular retention by polyglutamylation of folates is attenuated. Folic Acid 104-110 ATP binding cassette subfamily C member 1 Homo sapiens 54-58 12486126-4 2003 We therefore explored the possibility that folate efflux activity mediated by members of the multidrug resistance protein (MRP) family was impaired in CEM-7A cells. Folic Acid 43-49 ATP binding cassette subfamily C member 1 Homo sapiens 93-121 12486126-4 2003 We therefore explored the possibility that folate efflux activity mediated by members of the multidrug resistance protein (MRP) family was impaired in CEM-7A cells. Folic Acid 43-49 ATP binding cassette subfamily C member 1 Homo sapiens 123-126 12486126-12 2003 These results establish for the first time that MRP1 is the primary folate efflux route in CEM leukemia cells and that the loss of folate efflux activity is an efficient means of markedly augmenting cellular folate pools. Folic Acid 68-74 ATP binding cassette subfamily C member 1 Homo sapiens 48-52 12486126-12 2003 These results establish for the first time that MRP1 is the primary folate efflux route in CEM leukemia cells and that the loss of folate efflux activity is an efficient means of markedly augmenting cellular folate pools. Folic Acid 131-137 ATP binding cassette subfamily C member 1 Homo sapiens 48-52 12486126-12 2003 These results establish for the first time that MRP1 is the primary folate efflux route in CEM leukemia cells and that the loss of folate efflux activity is an efficient means of markedly augmenting cellular folate pools. Folic Acid 131-137 ATP binding cassette subfamily C member 1 Homo sapiens 48-52 12486126-13 2003 These findings suggest a functional role for MRP1 in the maintenance of cellular folate homeostasis. Folic Acid 81-87 ATP binding cassette subfamily C member 1 Homo sapiens 45-49 33164984-3 2020 The folate pathway genes SLC19A1, ABCC1, ABCC4, FPGS, and MTHFD1 significantly influenced intracellular MTXPG levels (P = 2.9 x 10-3 to 3.7 x 10-8). Folic Acid 4-10 ATP binding cassette subfamily C member 1 Homo sapiens 34-39