PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8597423-17 1995 Capsaicin pretreatment diminished the enhanced cytokine production in response to stress, such that levels of TNF alpha and IL-6 approximated those of control mice. Capsaicin 0-9 tumor necrosis factor Mus musculus 110-119 34862806-7 2022 In the thermal stimulation in animals injected with capsaicin, the compound showed antinociceptive effect by oral and intraplantar routes, besides to reducing the levels of TNF-alpha, IL-1beta and PGE2 in the paws previously administered with capsaicin. Capsaicin 52-61 tumor necrosis factor Mus musculus 173-182 34862806-7 2022 In the thermal stimulation in animals injected with capsaicin, the compound showed antinociceptive effect by oral and intraplantar routes, besides to reducing the levels of TNF-alpha, IL-1beta and PGE2 in the paws previously administered with capsaicin. Capsaicin 243-252 tumor necrosis factor Mus musculus 173-182 34328106-10 2021 Tissue gene expression of psoriatic core cytokines induced by imiquimod (including IL-23, IL-17A, IL-22, TNF-alpha, and IL-6) were greatly decreased by capsaicin application. Capsaicin 152-161 tumor necrosis factor Mus musculus 105-114 34235954-9 2021 Overall, capsaicin reduced the secretion of inflammatory cytokines (P<0.01), interleukins, TNF-alpha (P<0.01), and NO by inhibiting the nuclear factor-kappa B and microtubule-associated protein kinase signaling pathways, and thereby reduced lipopolysaccharide-induced inflammatory response in macrophages. Capsaicin 9-18 tumor necrosis factor Mus musculus 91-100 32811220-0 2020 Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-alpha secretion from M1 macrophages. Capsaicin 0-9 tumor necrosis factor Mus musculus 76-85 32811220-7 2020 Capsaicin inhibited M1 polarization of macrophage by regulating Notch signaling leading to the reduced secretion of inflammatory cytokine TNF-alpha that correspondingly attenuates myofibroblasts regeneration and fibrosis formation of hepatocyte stellate cells (HSCs). Capsaicin 0-9 tumor necrosis factor Mus musculus 138-147 32811220-8 2020 CONCLUSION: Taken together, capsaicin alleviates liver fibrosis by inactivation of Notch signaling and further inhibiting TNF-alpha secretion from M1 macrophage. Capsaicin 28-37 tumor necrosis factor Mus musculus 122-131 30100034-7 2018 RESULTS: Capsaicin pretreatment reduced wet-to-dry ratio, pathologic score, alveolar-arterial oxygen gradient (A-aDO2), and IL1beta, IL6, and TNFalpha levels in WT mice, with no effects in KO mice. Capsaicin 9-18 tumor necrosis factor Mus musculus 142-150 28659824-8 2017 The Cap-evoked Ca2+ influx was markedly enhanced in the neurons incubated with TNFalpha (50 ng/ml) for ~24 h, and this sensitizing effect was attenuated in the neurons isolated from the TNF-receptor double homozygous mutant mice. Capsaicin 4-7 tumor necrosis factor Mus musculus 79-87 28890700-12 2017 Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-alpha, IL-1beta, and IL-6 levels as compared with the normal diet. Capsaicin 27-36 tumor necrosis factor Mus musculus 153-162 28587842-5 2017 Accompanying these inflammatory reactions, the sensitivity of vagal pulmonary C-fibers and silent rapidly adapting receptors to capsaicin, a selective agonist of transient receptor potential vanilloid type 1 receptor, was markedly elevated after the TNFalpha treatment. Capsaicin 128-137 tumor necrosis factor Mus musculus 250-258 28587842-6 2017 A distinct increase in the sensitivity to capsaicin induced by TNFalpha was also observed in isolated pulmonary sensory neurons, suggesting that the sensitizing effect is mediated primarily through a direct action of TNFalpha on these neurons. Capsaicin 42-51 tumor necrosis factor Mus musculus 63-71 28587842-6 2017 A distinct increase in the sensitivity to capsaicin induced by TNFalpha was also observed in isolated pulmonary sensory neurons, suggesting that the sensitizing effect is mediated primarily through a direct action of TNFalpha on these neurons. Capsaicin 42-51 tumor necrosis factor Mus musculus 217-225 28659824-8 2017 The Cap-evoked Ca2+ influx was markedly enhanced in the neurons incubated with TNFalpha (50 ng/ml) for ~24 h, and this sensitizing effect was attenuated in the neurons isolated from the TNF-receptor double homozygous mutant mice. Capsaicin 4-7 tumor necrosis factor Mus musculus 79-82 26894912-6 2016 TNF-alpha cTg mice displayed increased trigeminal Cdk5 activity, and this increase was associated with elevated levels of phospho-T407-TRPV1 and capsaicin-evocated Ca influx in cultured trigeminal neurons. Capsaicin 145-154 tumor necrosis factor Mus musculus 0-9 23481698-8 2013 We found that tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS) directly activate cultured vagal afferent neurons and that almost all TNFalpha and LPS responsive neurons were sensitive to capsaicin. Capsaicin 206-215 tumor necrosis factor Mus musculus 14-41 28962318-5 2014 Treatment with LPS (20 mg/kg, ip) + Cap (4 mg/kg, sc)-treated group was significantly decreased both circulating sTNF levels (after 1 h only) and TNF-alpha mRNA expression (after 6 h) compared to the LPS-treated group. Capsaicin 36-39 tumor necrosis factor Mus musculus 146-155 28962318-7 2014 Since Cap inhibits this initial increase as biomarkers, circulating sTNF, it is considered a potent treatment option for TNF-alpha-related diseases, such as septicemia. Capsaicin 6-9 tumor necrosis factor Mus musculus 121-130 25527778-6 2015 Hypothalamic TNF-alpha increased in capsaicin-treated mice, whereas intracerebroventricular infusion of the TNF-alpha blocker etanercept prevented capsaicin-induced upregulation of alpha-ENaCs. Capsaicin 36-45 tumor necrosis factor Mus musculus 13-22 25527778-6 2015 Hypothalamic TNF-alpha increased in capsaicin-treated mice, whereas intracerebroventricular infusion of the TNF-alpha blocker etanercept prevented capsaicin-induced upregulation of alpha-ENaCs. Capsaicin 147-156 tumor necrosis factor Mus musculus 108-117 23481698-8 2013 We found that tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS) directly activate cultured vagal afferent neurons and that almost all TNFalpha and LPS responsive neurons were sensitive to capsaicin. Capsaicin 206-215 tumor necrosis factor Mus musculus 43-51 23481698-8 2013 We found that tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS) directly activate cultured vagal afferent neurons and that almost all TNFalpha and LPS responsive neurons were sensitive to capsaicin. Capsaicin 206-215 tumor necrosis factor Mus musculus 152-160 21333704-7 2011 In addition, capsaicin significantly lowered the KA-induced increase in the concentration of the cytokines IL-1beta and TNF-alpha in the brain. Capsaicin 13-22 tumor necrosis factor Mus musculus 120-129 18463260-4 2008 TNFalpha enhanced the expression of the nociceptor-specific heat transducer ion channel transient receptor potential vanilloid 1 (TRPV1) and increased the amplitudes of capsaicin and heat-activated ionic currents via p38/MAP (mitogen-activated protein) kinase and PKC (protein kinase C). Capsaicin 169-178 tumor necrosis factor Mus musculus 0-8 19878665-6 2010 Capsaicin and SA13353 increased serum neuropeptide levels, and calcitonin gene-related peptide fragment 8-37 (CGRP(8)(-)(37)), a CGRP antagonist, partially blocked the inhibitory effects of capsaicin and SA13353 on LPS-induced TNF-alpha production. Capsaicin 0-9 tumor necrosis factor Mus musculus 227-236 15304360-0 2004 Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism. Capsaicin 0-9 tumor necrosis factor Mus musculus 37-64 18264118-9 2008 SR140333 and capsaicin significantly inhibited the toxin-induced release of TNF-alpha and IL-1beta. Capsaicin 13-22 tumor necrosis factor Mus musculus 76-85 15304360-7 2004 Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma. Capsaicin 89-98 tumor necrosis factor Mus musculus 114-122 15304360-7 2004 Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma. Capsaicin 170-179 tumor necrosis factor Mus musculus 114-122 15304360-3 2004 In order to further clarify the mechanism underlying the anti-inflammatory action of capsaicin, we investigated whether capsaicin alters PPARgamma activity, which regulates the production of the pro-inflammatory cytokine TNFalpha. Capsaicin 120-129 tumor necrosis factor Mus musculus 221-229 15304360-4 2004 Capsaicin significantly inhibited the production of TNFalpha by macrophages in a dose-dependent manner. Capsaicin 0-9 tumor necrosis factor Mus musculus 52-60 15304360-5 2004 Simultaneous exposure of the cells to capsaicin and PPARgamma agonist troglitazone or RXR agonist LG100268 resulted in stronger inhibition of TNFalpha production compared to the cells treated with either capsaicin, troglitazone, or LG100268 alone. Capsaicin 38-47 tumor necrosis factor Mus musculus 142-150 11994487-3 2002 We report in this work that TNF-alpha increases the susceptibility of sensory neurons to dinitrobenzene sulfonic acid (DNS) and capsaicin, leading to a tracheal vascular hyperpermeability response in DNFB-sensitized and DNS-challenged mice. Capsaicin 128-137 tumor necrosis factor Mus musculus 28-37 12649350-4 2003 Depletion of primary afferent nerve fibers by neonatal capsaicin treatment down-regulated circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) and protected mice from GalN/LPS-induced liver injury. Capsaicin 55-64 tumor necrosis factor Mus musculus 142-169 12649350-4 2003 Depletion of primary afferent nerve fibers by neonatal capsaicin treatment down-regulated circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) and protected mice from GalN/LPS-induced liver injury. Capsaicin 55-64 tumor necrosis factor Mus musculus 171-179