PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
16827131-4	2006	Capsaicin-induced apoptosis was associated with the elevation of intracellular reactive oxygen species and Ca2+ production, decreased the levels of mitochondrial membrane potential, promoted cytochrome c release and increased the activation of caspase-3.	Capsaicin	0-9	cytochrome c, somatic	Homo sapiens	191-203	
20354008-9	2010	Release of cytochrome c from mitochondria, activation of caspase-3, and condensed nuclear chromatin were evident 6 h after capsaicin exposure, but cytotoxicity was unaffected by a pan-caspase inhibitor (zVAD-fmk, 50 microM).	Capsaicin	123-132	cytochrome c, somatic	Homo sapiens	11-23	
19331147-6	2009	The protein levels of Bcl-2 decreased and Bax increased in the mitochondrial fraction while the Bax protein decreased, and p53 and cytochrome c protein levels increased in the cytosolic fraction in HepG2 cells after capsaicin treatment for 24 h by Western blot.	Capsaicin	216-225	cytochrome c, somatic	Homo sapiens	131-143	
19002586-5	2008	Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.	Capsaicin	39-48	cytochrome c, somatic	Homo sapiens	165-177	
19002586-9	2008	Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.	Capsaicin	12-21	cytochrome c, somatic	Homo sapiens	163-175	
34939720-5	2022	We found that capsaicin increased TOS, 8-OHdG, CASP3, CYC, Bax, and NOX4 levels, and decreased Bcl-2, GSH, and SIRT1 in a concentration-dependent manner in HepG2 cells.	Capsaicin	14-23	cytochrome c, somatic	Homo sapiens	54-57	
34939720-6	2022	However, especially low capsaicin concentration (128.75 microM) enhanced GSH and SIRT levels and reduced TOS, CASP3, CYC, 8-OHdG, and NOX4 levels in HL-7702 cells (p < 0.05).	Capsaicin	24-33	cytochrome c, somatic	Homo sapiens	117-120	
34939720-7	2022	Interestingly, 128.75 and 172.8 microM capsaicin treatment increased SIRT1 expression levels in HL-7702 cells, resulting in an increase in GSH levels and a decrease in TOS, CYC, CAPS3, and 8-OHdG levels through NOX4 inhibition.	Capsaicin	39-48	cytochrome c, somatic	Homo sapiens	173-176	
27748914-5	2016	The apoptosis-inducing effects of Cap and DHC in U251 cells were associated with the generation of reactive oxygen species, increased Ca2+ concentrations, mitochondrial depolarization, release of cytochrome c into the cytosol and activation of caspase-9 and -3.	Capsaicin	34-37	cytochrome c, somatic	Homo sapiens	196-208	
22665354-5	2012	The observed increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels following capsaicin treatment indicated that the apoptotic response was mitochondrial pathway-dependent.	Capsaicin	105-114	cytochrome c, somatic	Homo sapiens	35-47