PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32791143-2 2020 Sensitivity of TRPV1 to several stimuli is known to vary among species, specifically, the avian orthologue is nearly insensitive to capsaicin. Capsaicin 132-141 transient receptor potential cation channel subfamily V member 1 Gallus gallus 15-20 32791143-8 2020 Low [Na+]o synergistically potentiated the capsaicin- and proton-induced TRPV1 activation in cDRG neurons. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Gallus gallus 73-78 32833423-11 2020 Consistently, the lack of effect of KA in activating chicken TRPV1, which is insensitive to capsaicin suggests that there is a significant overlap between the sites of KA and capsaicin activation of TRPV1. Capsaicin 175-184 transient receptor potential cation channel subfamily V member 1 Gallus gallus 199-204 32415171-0 2020 A single TRPV1 amino acid controls species sensitivity to capsaicin. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Gallus gallus 9-14 32415171-1 2020 Chili peppers produce capsaicin (a vanilloid) that activates the transient receptor potential cation channel subfamily V member 1 (TRPV1) on sensory neurons to alter their membrane potential and induce pain. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Gallus gallus 65-129 32415171-1 2020 Chili peppers produce capsaicin (a vanilloid) that activates the transient receptor potential cation channel subfamily V member 1 (TRPV1) on sensory neurons to alter their membrane potential and induce pain. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Gallus gallus 131-136 32415171-2 2020 To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids. Capsaicin 165-174 transient receptor potential cation channel subfamily V member 1 Gallus gallus 189-194 32415171-2 2020 To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids. Capsaicin 165-174 transient receptor potential cation channel subfamily V member 1 Gallus gallus 189-194 32415171-8 2020 Our study demonstrates that a subtle modification of TRPV1 in different species globally alters capsaicin responses. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Gallus gallus 53-58 28637949-4 2017 Both mammalian and chicken TRPV1 (cTRPV1) are activated by heat and acid, but unlike its mammalian counterpart, cTRPV1 is only faintly activated by capsaicin. Capsaicin 148-157 transient receptor potential cation channel subfamily V member 1 Gallus gallus 27-32 28637949-7 2017 Thus, we hypothesized that the increase of carbohydrate oxidation by AITC in mammals is induced by the binding of AITC to the capsaicin-binding site of TRPV1. Capsaicin 126-135 transient receptor potential cation channel subfamily V member 1 Gallus gallus 152-157 28637949-8 2017 In this study, we performed a comparative study using chickens and mice, since chickens are thought to partly lack the capsaicin-binding site of TRPV1. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Gallus gallus 145-150 18474376-0 2008 Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Gallus gallus 66-71 18474376-8 2008 These findings suggest that a CAP-sensitive TRPV1-independent pathway may be involved in pathophysiological hypothermic reactions through the mediation of NO in chickens. Capsaicin 30-33 transient receptor potential cation channel subfamily V member 1 Gallus gallus 44-49 17761445-0 2007 Involvement of a capsaicin-sensitive TRPV1-independent mechanism in lipopolysaccharide-induced fever in chickens. Capsaicin 17-26 transient receptor potential cation channel subfamily V member 1 Gallus gallus 37-42 17761445-8 2007 These findings suggest that a capsaicin-sensitive TRPV1-independent mechanism may be involved in LPS-induced fever. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Gallus gallus 50-55