PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21474433-2 2011 Application of capsaicin (100 muM) attenuated vectorial anion transport, estimated as short-circuit currents (I(SC)), before and after stimulation by forskolin (10 muM) with concomitant reduction of cytosolic cyclic AMP (cAMP) levels. Capsaicin 15-24 cathelicidin antimicrobial peptide Homo sapiens 221-225 21474433-3 2011 The capsaicin-induced inhibition of I(SC) was also observed in the response to 8-bromo-cAMP (1 mM, a cell-permeable cAMP analog) and 3-isobutyl-1-methylxanthine (1 mM, an inhibitor of phosphodiesterases). Capsaicin 4-13 cathelicidin antimicrobial peptide Homo sapiens 87-91 21474433-3 2011 The capsaicin-induced inhibition of I(SC) was also observed in the response to 8-bromo-cAMP (1 mM, a cell-permeable cAMP analog) and 3-isobutyl-1-methylxanthine (1 mM, an inhibitor of phosphodiesterases). Capsaicin 4-13 cathelicidin antimicrobial peptide Homo sapiens 116-120 21474433-4 2011 The capsaicin-induced inhibition of I(SC) was attributed to suppression of bumetanide (an inhibitor of the basolateral Na(+)-K(+)-2 Cl(-) cotransporter 1)- and 4,4"-dinitrostilbene-2,2"-disulfonic acid (an inhibitor of basolateral HCO(3)(-)-dependent anion transporters)-sensitive components, which reflect anion uptake via basolateral cAMP-dependent anion transporters. Capsaicin 4-13 cathelicidin antimicrobial peptide Homo sapiens 336-340 21474433-5 2011 In contrast, capsaicin potentiated apical Cl(-) conductance, which reflects conductivity through the cystic fibrosis transmembrane conductance regulator, a cAMP-regulated Cl(-) channel. Capsaicin 13-22 cathelicidin antimicrobial peptide Homo sapiens 156-160 21474433-9 2011 Collectively, capsaicinoids inhibit cAMP-mediated anion transport through down-regulation of basolateral anion uptake, paradoxically accompanied by up-regulation of apical cystic fibrosis transmembrane conductance regulator-mediated anion conductance. Capsaicin 14-27 cathelicidin antimicrobial peptide Homo sapiens 36-40