PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17760719-11 2007 We confirmed that capsaicin inhibited IL-8 mRNA expression after infection of gastric epithelial cells with H. pylori for 6 hours. Capsaicin 18-27 C-X-C motif chemokine ligand 8 Homo sapiens 38-42 17760719-14 2007 CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways. Capsaicin 30-39 C-X-C motif chemokine ligand 8 Homo sapiens 68-72 17760719-3 2007 Herein, we demonstrated that capsaicin inhibited the release of pro-inflammatory cytokine, interleukin-8 (IL-8) by H. pylori-infected gastric epithelial cells through nuclear factor-kappaB (NF-kappaB) signal pathway. Capsaicin 29-38 C-X-C motif chemokine ligand 8 Homo sapiens 106-110 17760719-6 2007 We measured IL-8 mRNA transcripts in H. pylori-infected gastric epithelial cells co-treated with capsaicin by reverse transcriptase-polymerase chain reaction analysis. Capsaicin 97-106 C-X-C motif chemokine ligand 8 Homo sapiens 12-16 17760719-14 2007 CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways. Capsaicin 30-39 C-X-C motif chemokine ligand 8 Homo sapiens 164-168 17760719-9 2007 RESULTS: Capsaicin inhibits H. pylori-induced IL-8 production by gastric epithelial cells in dose- and time-dependent manner. Capsaicin 9-18 C-X-C motif chemokine ligand 8 Homo sapiens 46-50 17760719-10 2007 Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control). Capsaicin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 59-63 17760719-15 2007 We conclude that capsaicin can be proposed as a potential anti-inflammatory drug by inhibition of the production of IL-8 in H. pylori-infected gastric epithelium. Capsaicin 17-26 C-X-C motif chemokine ligand 8 Homo sapiens 116-120 17760719-10 2007 Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control). Capsaicin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 170-174 12034025-6 2002 Further, downregulation of IL-8 expression in capsaicin-treated melanoma cells resulted in inhibition of in vitro cell proliferation. Capsaicin 46-55 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 12490594-9 2003 Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2, and the stimulated release was attenuated by capsazepine. Capsaicin 35-44 C-X-C motif chemokine ligand 8 Homo sapiens 86-99 10657523-6 1999 BEAS-2B cells also responded to the botanical irritant, capsaicin (10 microM) with increases in [Ca(2+)](i) and IL-8 cytokine release after 4 h exposure. Capsaicin 56-65 C-X-C motif chemokine ligand 8 Homo sapiens 112-116 12034025-0 2002 Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation. Capsaicin 91-100 C-X-C motif chemokine ligand 8 Homo sapiens 111-124 12034025-2 2002 Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells. Capsaicin 12-21 C-X-C motif chemokine ligand 8 Homo sapiens 183-187 12034025-2 2002 Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells. Capsaicin 23-55 C-X-C motif chemokine ligand 8 Homo sapiens 183-187 12034025-3 2002 The inhibition of IL-8 expression was dependent on the concentration of capsaicin and duration of treatment. Capsaicin 72-81 C-X-C motif chemokine ligand 8 Homo sapiens 18-22 12034025-5 2002 Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression. Capsaicin 33-42 C-X-C motif chemokine ligand 8 Homo sapiens 151-155 21745629-2 2011 In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages. Capsaicin 79-88 C-X-C motif chemokine ligand 8 Homo sapiens 232-245 34941893-5 2021 Additionally, high concentrations of capsaicin (0.02-2 mM) damage enterocytes (Caco-2 and HT-29) as indicated by cell viability test, supernatant cytokine (IL-8), transepithelial electrical resistance (TEER) and transepithelial FITC-dextran (4.4 kDa) but were attenuated by Lactobacillus condition media (LCM) from both probiotic-strains. Capsaicin 37-46 C-X-C motif chemokine ligand 8 Homo sapiens 156-160 22790593-8 2012 In HET-1A cells, the TRPV1 agonist capsaicin reproduced these findings for mRNA of the inflammatory mediators lyso-PAF AT, IL-8, and eotaxin-1. Capsaicin 35-44 C-X-C motif chemokine ligand 8 Homo sapiens 123-127 21636531-5 2011 Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA. Capsaicin 65-74 C-X-C motif chemokine ligand 8 Homo sapiens 0-13 21636531-5 2011 Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA. Capsaicin 65-74 C-X-C motif chemokine ligand 8 Homo sapiens 15-19 21636531-8 2011 Capsaicin and acid induced IL-8 production in Het1A cells, and this production was diminished by antagonists of TRPV1. Capsaicin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 27-31 21636531-10 2011 Moreover, IL-8 production in capsaicin-stimulated Het1A cells was enhanced by synthetic HNE treatment. Capsaicin 29-38 C-X-C motif chemokine ligand 8 Homo sapiens 10-14 21745629-9 2011 Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity. Capsaicin 94-103 C-X-C motif chemokine ligand 8 Homo sapiens 69-73 31751886-10 2019 Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation. Capsaicin 22-31 C-X-C motif chemokine ligand 8 Homo sapiens 109-114 31751886-10 2019 Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation. Capsaicin 22-31 C-X-C motif chemokine ligand 8 Homo sapiens 115-119 27490714-7 2016 RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only. Capsaicin 33-42 C-X-C motif chemokine ligand 8 Homo sapiens 98-102 22221101-0 2012 Transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside Rg1 on capsaicin-induced interleukin-8 and prostaglandin E2 production in HaCaT cells. Capsaicin 101-110 C-X-C motif chemokine ligand 8 Homo sapiens 119-132 22221101-8 2012 More importantly, GRg1 dose-dependently inhibited capsaicin-induced PGE(2) and IL-8 secretion in HaCaT cells and HEK 293T-TRPV1 cells. Capsaicin 50-59 C-X-C motif chemokine ligand 8 Homo sapiens 79-83 21745629-0 2011 Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. Capsaicin 0-9 C-X-C motif chemokine ligand 8 Homo sapiens 91-104 21745629-2 2011 In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages. Capsaicin 79-88 C-X-C motif chemokine ligand 8 Homo sapiens 247-251 21745629-3 2011 To investigate whether capsaicin ameliorates palmitate-induced MIP-1 and IL-8 gene expressions, we treated THP-1 cells with palmitate in the presence or absence of capsaicin and measured MIP-1 and IL-8 by real-time polymerase chain reaction. Capsaicin 23-32 C-X-C motif chemokine ligand 8 Homo sapiens 73-77 21745629-4 2011 To elucidate the mechanism by which capsaicin effects on palmitate-induced MIP-1 and IL-8 gene expressions, we performed immunoblotting with stress kinase-related antibodies and measured palmitate oxidation and palmitate oxidation-related gene expression. Capsaicin 36-45 C-X-C motif chemokine ligand 8 Homo sapiens 85-89 21745629-6 2011 Treatment with capsaicin or FFA oxidation stimulators inhibited palmitate-induced MIP-1 and IL-8 expressions in THP-1 macrophages. Capsaicin 15-24 C-X-C motif chemokine ligand 8 Homo sapiens 92-96 22171160-7 2011 RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release. Capsaicin 9-18 C-X-C motif chemokine ligand 8 Homo sapiens 396-400 22171160-7 2011 RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release. Capsaicin 20-23 C-X-C motif chemokine ligand 8 Homo sapiens 396-400 20678598-3 2010 It has been shown that GRb1 and PF inhibited the productions of IL-8 and PGE2 induced by capsaicin (CAP) in HaCaT cells and HEK 293T-TRPV1 cells (which were transgenic and overexpressed TRPV1) but had no effect on HEK 293T mock cells (p<0.05). Capsaicin 89-98 C-X-C motif chemokine ligand 8 Homo sapiens 64-68