PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33752082-2	2021	Oxidants and UVA-light activate TRPV2 by oxidizing methionine pore residues which are conserved in the capsaicin-receptor TRPV1.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 2	Homo sapiens	32-37	
30761248-7	2019	Furthermore, TRPV1 was activated by capsaicin (EC 50 = 20.32 mum), and this effect was antagonized by AMG9810; TRPV2 was activated by a newly developed cannabinoid compound, O1821, and inhibited by tranilast.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 2	Homo sapiens	111-116	
17287441-13	2007	We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 2	Homo sapiens	163-168	
17287441-13	2007	We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 2	Homo sapiens	163-168	
30644819-3	2019	It was recently discovered that four mutations in TRPV2 are sufficient to render the channel sensitive to the TRPV1-specific vanilloid agonist resiniferatoxin (RTx).	Capsaicin	125-134	transient receptor potential cation channel subfamily V member 2	Homo sapiens	50-55	
30176215-2	2018	Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure-activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain fatty acid ethanolamides or primary amides acting as TRPV2 antagonists.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 2	Homo sapiens	93-98	
30176215-2	2018	Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure-activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain fatty acid ethanolamides or primary amides acting as TRPV2 antagonists.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 2	Homo sapiens	400-405	
27298359-3	2016	Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad).	Capsaicin	91-100	transient receptor potential cation channel subfamily V member 2	Homo sapiens	150-155	
27298359-3	2016	Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad).	Capsaicin	91-100	transient receptor potential cation channel subfamily V member 2	Homo sapiens	262-267	
27298359-4	2016	We found that binding of resiniferatoxin activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 2	Homo sapiens	152-157	
21044960-1	2010	The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3.	Capsaicin	190-199	transient receptor potential cation channel subfamily V member 2	Homo sapiens	379-384