PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22648626-0	2012	Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein beta activation.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-24	
20388821-0	2010	Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes.	Capsaicin	82-91	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	110-129	
20388821-3	2010	Capsaicin clearly inhibited cytochrome P450 3A4 activity, losing 50% of the activity at 21.5 micromol/L.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-47	
20388821-5	2010	Preincubation increased the capsaicin inhibitory activity against cytochrome P450 3A4 in a time-dependent manner.	Capsaicin	28-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-85	
20388821-7	2010	Capsaicin was shown to inhibit cytochrome P450 3A4, probably through a mechanism-based inhibition.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-50	
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	25-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132	
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	85-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-54	
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	85-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132	
22648626-3	2012	However, the influence of capsaicin on CYP3A4, its involvement in drug metabolism, and the underlying mechanisms remain unclear.	Capsaicin	26-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-45	
22648626-4	2012	METHODS AND RESULTS: Here, we examined the effect of capsaicin on CYP3A4 expression and the metabolism of CYP3A1 substrate, nifedipine in male Sprague-Dawley rats.	Capsaicin	53-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-72	
22648626-5	2012	Capsaicin induced the enzymatic activity and expression of CYP3A4 in HepG2 cells.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65	
22648626-6	2012	Treatment with a human pregnane X receptor (hPXR) inhibitor reduced the inductive effects of capsaicin on CYP3A4 expression.	Capsaicin	93-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	106-112	
22648626-10	2012	CONCLUSION: From these data, we conclude that capsaicin induces CYP3A4 expression in vitro and in vivo.	Capsaicin	46-55	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-70	
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	25-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-54	
22375877-6	2012	Time-dependent inhibition of CYP3A4/5 by capsaicin was found.	Capsaicin	41-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35	
22375877-2	2012	In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 activities in human liver microsomes.	Capsaicin	56-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	140-146