PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29520110-0 2018 Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice. Capsaicin 0-9 histone deacetylase 2 Mus musculus 22-27 29520110-3 2018 We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Capsaicin 14-23 histone deacetylase 2 Mus musculus 62-83 29520110-3 2018 We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Capsaicin 14-23 histone deacetylase 2 Mus musculus 85-90 29520110-3 2018 We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters. Capsaicin 14-23 histone deacetylase 2 Mus musculus 121-126 29520110-4 2018 Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Capsaicin 120-129 histone deacetylase 2 Mus musculus 40-45 29520110-4 2018 Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Capsaicin 210-219 histone deacetylase 2 Mus musculus 40-45 29520110-4 2018 Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression. Capsaicin 210-219 histone deacetylase 2 Mus musculus 187-192 29520110-5 2018 Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity. Capsaicin 48-57 histone deacetylase 2 Mus musculus 39-44 29520110-5 2018 Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity. Capsaicin 48-57 histone deacetylase 2 Mus musculus 141-146