PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33849430-5 2021 Mustard oil and capsaicin were used to stimulate TRPA1 and TRPV1 receptor channels. Capsaicin 16-25 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 49-54 35496916-7 2022 The majority of cells that co-expressed TRPM3 and BKRs also expressed TRPV1, however, only a small fraction co-expressed TRPA1, identified by calcium responses to capsaicin and supercinnamaldehyde, respectively. Capsaicin 163-172 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 121-126 32708653-5 2020 We provided evidence that resolvins inhibited neuropeptide release from the stimulated sensory nerve terminals by TRPV1 and TRPA1 activators capsaicin (CAPS) and allyl-isothiocyanate (AITC), respectively. Capsaicin 141-150 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 124-129 32708653-5 2020 We provided evidence that resolvins inhibited neuropeptide release from the stimulated sensory nerve terminals by TRPV1 and TRPA1 activators capsaicin (CAPS) and allyl-isothiocyanate (AITC), respectively. Capsaicin 152-156 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 124-129 29689522-8 2018 Experiments performed in mouse dorsal root ganglion (DRG) neurons revealed that genetic ablation of Trpa1 did not abolish the responses to LPS, but remain detected in 30% of capsaicin-sensitive cells. Capsaicin 174-183 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 100-105 32526913-1 2020 The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein. Capsaicin 79-88 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 4-42 32526913-1 2020 The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein. Capsaicin 79-88 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 44-49 32388008-5 2020 Liquiritin inhibited capsaicin- and allyl isothiocyanate-evoked TRPV1 and TRPA1 whole-cell currents, respectively, with a similar potency and maximal inhibition. Capsaicin 21-30 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 74-79 31981911-11 2020 Furthermore, this alkaloid reduces the capsaicin- and cinnamaldehyde-mediated Ca2+ influx, indicating a possible modulation of TRPV1 and TRPA1 channels, respectively. Capsaicin 39-48 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 137-142 27525636-0 2016 Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release. Capsaicin 0-9 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 93-98 27525636-11 2016 H2S activates capsaicin-sensitive sensory nerves through TRPA1 receptors and the resultant vasodilatation is mediated by the release of vasoactive sensory neuropeptides CGRP and substance P. Capsaicin 14-23 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 57-62 24830023-5 2014 The thermosensitive transient receptor potential (TRP) channels TRPV1 and TRPA1, which bind capsaicin and allyl isothiocyanate (mustard oil), respectively, are important for pain transmission. Capsaicin 92-101 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 74-79 27064319-5 2016 Long-term (4 h) treatment with glutamate receptor agonists (glutamate, quisqualate or DHPG) increased the proportion of neurons responding to capsaicin through activation of metabotropic glutamate receptor mGluR1, and only partially through the activation of mGluR5; engagement of these receptors was evident in neurons responding to allylisothiocyanate (AITC), a transient receptor potential ankyrin type 1 (TRPA1) agonist. Capsaicin 142-151 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 364-407 27064319-5 2016 Long-term (4 h) treatment with glutamate receptor agonists (glutamate, quisqualate or DHPG) increased the proportion of neurons responding to capsaicin through activation of metabotropic glutamate receptor mGluR1, and only partially through the activation of mGluR5; engagement of these receptors was evident in neurons responding to allylisothiocyanate (AITC), a transient receptor potential ankyrin type 1 (TRPA1) agonist. Capsaicin 142-151 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 409-414 26746673-1 2016 BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable cation channel that is expressed on capsaicin-sensitive sensory neurons, endothelial and inflammatory cells. Capsaicin 122-131 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 16-54 26746673-1 2016 BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable cation channel that is expressed on capsaicin-sensitive sensory neurons, endothelial and inflammatory cells. Capsaicin 122-131 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 56-61 26098441-7 2015 TRPA1 protein expression was significantly elevated in the vagina, and calcium transients evoked by mustard oil (TRPA1 ligand) or capsaicin (TRPV1 ligand) were significantly decreased in dorsal root ganglion from NVI mice, despite displaying increased depolarization-evoked calcium transients. Capsaicin 130-139 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 0-5 23685721-5 2013 However, silencing TRPV1(+) or TRPA1(+) neurons allowed allyl isothiocyanate or capsaicin, respectively, to evoke itch, implying that certain peripheral afferents may normally indirectly inhibit algogens from eliciting itch. Capsaicin 80-89 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 31-36 23596498-2 2013 Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1). Capsaicin 70-79 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 88-134 23596498-2 2013 Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1). Capsaicin 70-79 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 136-141 19828806-5 2009 This was associated with increased calcium influx and increased inward currents in small- and medium-sized primary sensory neurons of SNS-IKKbeta(-/-) mice during stimulation with capsaicin or Formalin, specific activators of transient receptor potentials TRPV1 and TRPA1 calcium channels, respectively. Capsaicin 180-189 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 266-271 22721614-1 2012 Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP). Capsaicin 97-106 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 14-52 22721614-1 2012 Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP). Capsaicin 97-106 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 54-59 20539005-5 2010 Agonists of TRPV4 and TRPA1 increased intracellular Ca(2+) concentration ([Ca(2+)](i)) in these neurons in culture, and neurons also responded to the TRPV1 agonist capsaicin and are thus nociceptors. Capsaicin 164-173 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 22-27 19059884-3 2009 Recent studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1), an ion channel largely restricted to a subset of capsaicin-sensitive sensory nerves, functions as a transducer capable of initiating reflex responses to many reactive chemical stimuli. Capsaicin 135-144 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 38-76 19059884-3 2009 Recent studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1), an ion channel largely restricted to a subset of capsaicin-sensitive sensory nerves, functions as a transducer capable of initiating reflex responses to many reactive chemical stimuli. Capsaicin 135-144 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 78-83 19419422-4 2009 A capsaicin-sensitive subset of rat and mouse trigeminal ganglion sensory neurons was activated with TRPA1-specific agonists, mustard oil and the cannabinoid WIN55,212. Capsaicin 2-11 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 101-106 18218683-6 2008 Capsaicin-sensitive, but not capsaicin-insensitive, lung-specific neurons responded to cinnamaldehyde, a TRPA1 agonist, with increases in intracellular calcium. Capsaicin 0-9 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 105-110 19171673-10 2009 9-OA-NO(2) evoked robust action potential discharge from capsaicin-sensitive fibers with slow conduction velocities (0.4-0.7 m/s), which was inhibited by the TRPA1 antagonist AP-18. Capsaicin 57-66 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 158-163 18272293-6 2008 In contrast, the intrathecal treatment with TRPA1 antisense oligodeoxynucleotide (2.5 nmol/site) and the degeneration of the subset of primary afferent fibers sensitive to capsaicin significantly reduced allyl isothiocyanate-induced nociception. Capsaicin 172-181 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 44-49 18272293-11 2008 Collectively, the present findings demonstrate that the TRPA1 agonist allyl isothiocyanate produces a consistent nociceptive response when injected into the mouse paw, an effect that seems to be mediated via activation of TRPA1 receptor and dependent on the capsaicin-sensitive fibers, release of histamine by mast cells and participation of tachykinins. Capsaicin 258-267 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 56-61 18218683-8 2008 Cinnamaldehyde also induced TRPA1-like inward currents (as measured by means of whole cell patch clamp recordings) in capsaicin-sensitive neurons. Capsaicin 118-127 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 28-33 18234885-0 2008 Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. Capsaicin 25-34 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 84-89 18234885-10 2008 Furthermore, the WIN- or AM1241-induced inhibition of capsaicin-evoked nocifensive behavior via peripheral actions is reversed in TRPA1 null-mutant mice. Capsaicin 54-63 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 130-135 18234885-9 2008 The knockdown of TRPA1 activity in neurons completely eliminates the desensitizing effects of WIN and AM1241 on capsaicin-activated currents. Capsaicin 112-121 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 17-22 17344381-6 2007 Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected. Capsaicin 13-22 transient receptor potential cation channel, subfamily A, member 1 Mus musculus 278-283