PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33128434-3 2021 Calcium peak stimulated by capsaicin, the ligand of TRPV1 channel, was decreased in neurons pre-irradiated with the combination of the two wavelengths. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-57 33327798-2 2021 This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves. Capsaicin 251-260 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-94 33327798-2 2021 This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves. Capsaicin 251-260 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 33327798-2 2021 This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves. Capsaicin 262-265 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-94 33327798-2 2021 This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves. Capsaicin 262-265 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 33641357-7 2021 Administration of capsaicin, TRPV1 agonist, in hindlimb evoked significantly greater increases in mean arterial pressure and renal sympathetic nerve activity in decerebrated T2D than control. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-34 34006826-7 2021 In the rat OA model, intra-articular injection of capsaicin (CPS), a specific TRPV1 agonist, significantly attenuated OA phenotypes, including joint swelling, synovitis, cartilage damage, and osteophyte formation. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 34006826-7 2021 In the rat OA model, intra-articular injection of capsaicin (CPS), a specific TRPV1 agonist, significantly attenuated OA phenotypes, including joint swelling, synovitis, cartilage damage, and osteophyte formation. Capsaicin 61-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 33956370-6 2021 Administration of a TRPV1 agonist, capsaicin, increases levels of phosphorylated p70S6K (p-p70S6K; activation of p70S6K) on astrocytes, resulting in the survival of dopamine neurons and behavioral recovery through endogenous production of CNTF in the MPP+ -lesioned rat model of PD. Capsaicin 35-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 20-25 33272194-11 2020 CAP treatment deteriorated transient receptor potential vanilloid 1 (TRPV1)-positive neurons and increased caspase-3 signals in nodose ganglion (NG) neurons. Capsaicin 0-3 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-67 33420359-13 2021 Taken together, these preclinical results unveil the mode of action of AG1529 on TRPV1 channels and substantiate the tenet that this capsaicinoid-based soft drug is a promising candidate for drug development as a topical anti-pruritic and anti-inflammatory medication. Capsaicin 133-145 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 81-86 33272194-11 2020 CAP treatment deteriorated transient receptor potential vanilloid 1 (TRPV1)-positive neurons and increased caspase-3 signals in nodose ganglion (NG) neurons. Capsaicin 0-3 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 32738201-1 2020 The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by inflammatory mediators and contributes to acute and chronic pain. Capsaicin 4-13 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 36-41 33095918-9 2020 In rat DRG neurons, activin C enhanced capsaicin-induced TRPV1 currents. Capsaicin 39-48 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 32944976-13 2020 Pharmacologic and/or genetic disruption of TRPV1 abolished all these effects of capsaicin as well as vasoconstriction triggered by lysophosphatidic acid, a bioactive lipid generated by platelets and atherogenic plaques. Capsaicin 80-89 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-48 33070237-4 2020 Nephritis was induced by OX-7 antibodies in rats, 6 days later instrumented for recording of blood pressure (BP), heart rate (HR), drug administration, and intrarenal administration (IRA) of the TRPV1 agonist capsaicin to stimulate afferent renal nerve pathways containing SP and electrodes for renal sympathetic nerve activity (RSNA). Capsaicin 209-218 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 195-200 33077140-6 2020 For stimulation of TRPM8 ion channel, an application to the skin of 1% menthol was used, for TRPA1 - 0.04% allylisotiocianate, and for TRPV1 - capsaicin in a concentration of 0.001.The antigen binding in the spleen was two-times stimulated by activation of the cold-sensitive ion channel TRPM8 and much weaker by activation of warm-sensitive TRPV1 (by 15%), and another cold-sensitive ion channel TRPA1 (by 40%). Capsaicin 143-152 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 135-140 32453137-8 2020 A second application of capsaicin to the same eye had a lessened effect on tonic dopamine suggesting desensitization of TRPV1 channels in that eye. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-125 32574651-0 2020 Capsaicin-sensitive fibers mediate periorbital allodynia and activation of inflammatory cells after traumatic brain injury in rats: Involvement of TRPV1 channels in post-traumatic headache. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 147-152 32574651-4 2020 Thus, the involvement of fibers containing the transient receptor potential vanilloid 1 (TRPV1) channels on the PTH and inflammation after TBI through neonatal treatment with capsaicin are investigated. Capsaicin 175-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-94 32764237-2 2020 Understanding the protective mechanisms including the role of Transient Receptor Potential Ankyrin1 (TRPA1) and Vanilloid1 (TRPV1) channels localized on capsaicin-sensitive afferents and non-neuronal structures might identify novel therapeutic approaches. Capsaicin 153-162 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-129 32638638-5 2020 RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-56 32638638-5 2020 RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 212-217 32638638-5 2020 RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively. Capsaicin 76-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-56 32638638-5 2020 RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively. Capsaicin 76-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 212-217 32872656-9 2020 In accordance to our results, Capsaicin-induced vasorelaxation of the rat aorta is neither dependent of TRPV1 or CB2 receptors, but rather it is strongly suggested that a tandem mechanism between inactivation of L-type calcium channels and the direct activation of CB1 receptors is involved. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 104-109 32337274-8 2020 Capsaicin, a TRPV1 agonist, delivery aggravated the performance of SE rats. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 32415171-2 2020 To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 189-194 32415171-2 2020 To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 189-194 32415171-5 2020 Similarly, replacing corresponding rTRPV1 residue E570 with lysine or glutamine retained capsaicin sensitivity. Capsaicin 89-98 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-41 32365623-0 2020 Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate. Capsaicin 83-92 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 11-16 32365623-2 2020 The transient receptor potential vanilloid 1 (TRPV1) is the capsaicin receptor channels that are involved in a variety of functions like transduction and transmission of the physiological stimulus. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-44 32365623-2 2020 The transient receptor potential vanilloid 1 (TRPV1) is the capsaicin receptor channels that are involved in a variety of functions like transduction and transmission of the physiological stimulus. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 46-51 32365623-3 2020 Subcutaneous injection of capsaicin to a newborn rat leads to involuntary lifelong TRPV1 desensitization. Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 32365623-4 2020 Various physiological changes including sensory and homeostatic actions in the body associated with neonatal capsaicin treatment are induced by direct TRPV1 channel targeting. Capsaicin 109-118 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 151-156 32345727-4 2020 Simultaneous optical monitoring of CaCC activity and Ca2+ dynamics revealed that the TRPV1 ligand capsaicin activated CaCCs. Capsaicin 98-107 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-90 32345727-5 2020 However, depletion of endoplasmic reticulum (ER) Ca2+ stores reduced capsaicin-induced Ca2+ increases and CaCC activation, suggesting that ER Ca2+ release contributed to TRPV1-induced CaCC activation. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 170-175 32595512-10 2020 Overall, our results indicate different firing patterns evoked by inflammatory mediators and capsaicin via TRPV1 that correlate with the respective subsequent pain sensation. Capsaicin 93-102 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 107-112 32375895-0 2020 Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells. Capsaicin 80-89 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 32337274-13 2020 Interestingly, all these effects of Dex were partially counteracted by the TRPV1 agonist, capsaicin (P < 0.05). Capsaicin 90-99 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 75-80 31577558-8 2020 Local injection of nerve growth factor (3 microg/50 microl) or the TRPV1 agonist capsaicin (1 mug/50 mul), but not neurotrophin-3 injection (1 microg/50 microl), resulted in long-lasting facial heat hyperalgesia, which was both significantly reduced by previous neurotrophin-3 local treatment. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 67-72 32078575-4 2020 Using Ca2+ imaging, we further investigated in neurons the effects of gabapentinoids upon stimulation with the TRPV-1 agonist capsaicin. Capsaicin 126-135 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-117 32039693-9 2020 These results indicate that a Cap-induced decrease in the LV contractility, like in cases of hyperthermia, are due to the down-regulation of the total calcium handling in E-C coupling, suggesting that negative inotropic effect in hyperthermia-heart is, at least in part, mediated through TRPV1 signaling pathway. Capsaicin 30-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 288-293 31383364-12 2019 NGF increased capsaicin current amplitude from 144 (42) to 840 (132) pA (P<0.05), which was blocked by the TRPV1 antagonist 5"-iodoresiniferatoxin. Capsaicin 14-23 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 110-115 31721716-4 2020 The low (1mg/kg) or high (100mg/kg) dose of capsaicin was injected subcutaneously before I/R to activate or desensitize TRPV1, respectively. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-125 31296147-2 2019 Transient receptor potential vanilloid subfamily member 1 (TRPV1), a new target of the analgesics, activated by heat, protons and capsaicin and the hot component of pepper. Capsaicin 130-139 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-64 31632242-12 2019 Mitigation of NIHL could be achieved by using capsaicin (TRPV1 agonist that rapidly desensitizes TRPV1. Capsaicin 46-55 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 31632242-12 2019 Mitigation of NIHL could be achieved by using capsaicin (TRPV1 agonist that rapidly desensitizes TRPV1. Capsaicin 46-55 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 97-102 31617735-9 2020 Owing that TRPV1 receptors of laryngeal C-fibers are responsible for the CAP-triggered apneas, LA impact on the activity of laryngeal C-neurons retrogradely traced by DiI was subsequently studied using a patch-clamp approach. Capsaicin 73-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 11-16 31697943-3 2020 Cell bodies for the vagal afferent fibers are located within the nodose ganglion (NG) and the majority of vagal afferent axons are unmyelinated C fibers that are sensitive to capsaicin through activation of transient receptor potential vanilloid-1 (TRPV1) channels. Capsaicin 175-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 207-247 31697943-3 2020 Cell bodies for the vagal afferent fibers are located within the nodose ganglion (NG) and the majority of vagal afferent axons are unmyelinated C fibers that are sensitive to capsaicin through activation of transient receptor potential vanilloid-1 (TRPV1) channels. Capsaicin 175-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 249-254 31576531-3 2020 We expressed the transient receptor potential vanilloid 1 (TRPV1) channel from rat (r) in worms" ASH neurons and determined its sensitivity to the tarantula double-knot toxin (DkTx) and the active component of chili peppers (capsaicin). Capsaicin 225-234 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 17-57 31576531-3 2020 We expressed the transient receptor potential vanilloid 1 (TRPV1) channel from rat (r) in worms" ASH neurons and determined its sensitivity to the tarantula double-knot toxin (DkTx) and the active component of chili peppers (capsaicin). Capsaicin 225-234 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-64 32985330-6 2020 To analyze the capsaicin-induced mitochondrial damage and its relevant cellular events in detail, we performed cell-based assays using TRPV1-expressing PC12 cells. Capsaicin 15-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 135-140 32985330-11 2020 Collectively, although trigeminal ganglion neurons transiently exhibit mitochondrial damage and TRPV1 dysfunction following moderate capsaicin exposure, they appear to be resilient to such a challenge. Capsaicin 133-142 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 31493465-7 2019 Here, we studied whether or not chronic pain could alter the response of TRPV1 channels to exogenous, capsaicin through study of synaptic transmission and neural activity in rat SG neurons. Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 73-78 31493465-11 2019 Importantly, the capsaicin-induced inward currents were conducted by TRPV1 and required calcium influx that was independent of voltage-gated calcium channels. Capsaicin 17-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 31493465-12 2019 Our study provides fundamental evidence that chronic inflammation and neuropathic pain models amplify the release of glutamate through the activation of TRPV1 in central axon terminals, and that facilitation of TRPV1 function in rat spinal SG neurons may contribute to enhanced capsaicin-induced inward currents. Capsaicin 278-287 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 211-216 31383364-13 2019 Exogenous NGF enhanced capsaicin-induced Akt/ERK and TRPV1 activation in PC12 neuroendocrine tumour cells in culture. Capsaicin 23-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-58 31190106-8 2019 However, TRPV-1 agonists capsaicin significantly abrogated the neuroprotective effects of EA pretreatment in MCAO rats accompanying enhancement of TRPV-1 expression. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-15 31190106-8 2019 However, TRPV-1 agonists capsaicin significantly abrogated the neuroprotective effects of EA pretreatment in MCAO rats accompanying enhancement of TRPV-1 expression. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 147-153 31551772-2 2019 The transient receptor potential V1 ion channel (TRPV1) is a peripheral pain generator activated and sensitized by heat, capsaicin, and a variety of endogenous ligands. Capsaicin 121-130 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-54 31557799-1 2019 The purpose of the present study was to analyze the actions of transient receptor potential vanilloid type 1 (TRPV1) agonist capsaicin (CS) and of its antagonist capsazepine (CZ), on cardiac function as well as endothelial biomarkers and some parameters related with nitric oxide (NO) release in L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-108 31557799-1 2019 The purpose of the present study was to analyze the actions of transient receptor potential vanilloid type 1 (TRPV1) agonist capsaicin (CS) and of its antagonist capsazepine (CZ), on cardiac function as well as endothelial biomarkers and some parameters related with nitric oxide (NO) release in L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 110-115 31557799-1 2019 The purpose of the present study was to analyze the actions of transient receptor potential vanilloid type 1 (TRPV1) agonist capsaicin (CS) and of its antagonist capsazepine (CZ), on cardiac function as well as endothelial biomarkers and some parameters related with nitric oxide (NO) release in L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats. Capsaicin 136-138 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 110-115 31551772-8 2019 Primary sensory neuron cultures also were treated with the latex extract or vehicle for 15 min followed by stimulation with the TRPV1 agonist capsaicin. Capsaicin 142-151 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 128-133 31551772-11 2019 Blocking TRPV1, but not opioid receptors, attenuated the onset of analgesia and capsaicin-induced CGRP release. Capsaicin 80-89 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-14 30768945-7 2019 By using our novel cluster analysis of pain spikes, we demonstrated that 42% of fibers responded to Piezo1 agonist and 20% of trigeminal fibers were activated by Yoda1 and by capsaicin, suggesting expression of Piezo receptors in TRPV1 positive peptidergic nociceptive nerve fibers. Capsaicin 175-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 230-235 30898677-7 2019 The effect of capsaicin was completely abolished by a TRPV1 channel blocker AMG9810 (0.1 muM). Capsaicin 14-23 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 30927254-5 2019 KEY RESULTS: The classical TRPV1 agonist capsaicin as well as TRPV1 antagonists A-889425, BCTC, and capsazepine directly inhibited Cav 3 channels. Capsaicin 41-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 31186372-2 2019 Studies on the internalization of TRPV1 have mainly focused on that induced by capsaicin or other agonists. Capsaicin 79-88 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 34-39 30969886-0 2019 Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1. Capsaicin 33-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 75-80 30969886-3 2019 In the present study, we examined the effect of dry eye on the sensitivity of cool cells to the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin. Capsaicin 153-162 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-136 30969886-3 2019 In the present study, we examined the effect of dry eye on the sensitivity of cool cells to the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin. Capsaicin 153-162 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 138-143 30969886-9 2019 Capsaicin-induced changes were prevented by the application of the TRPV1 antagonist capsazepine. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 67-72 30904671-1 2019 Capsaicin is an agonist for transient receptor potential vanilloid 1 (TRPV1), and acute injection results in an increased frequency and tidal volume in young rats. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 28-68 30904671-1 2019 Capsaicin is an agonist for transient receptor potential vanilloid 1 (TRPV1), and acute injection results in an increased frequency and tidal volume in young rats. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-75 30936039-1 2019 The Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin, low pH and noxious heat. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-68 30936039-1 2019 The Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin, low pH and noxious heat. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-75 30936039-5 2019 A novel, in vivo, electrophysiological bone-nerve preparation, recently developed in our laboratory, was used to make recordings of the activity and sensitivity of bone afferent neurons in response to application of the TRPV1 agonist capsaicin to the marrow cavity. Capsaicin 234-243 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 220-225 30560330-12 2019 SLIGRL-NH2, a PAR2 agonist, and capsaicin, a TRPV1 agonist, blocked the effects of probiotic VSL#3. Capsaicin 32-41 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 45-50 30858408-5 2019 Here we report that direct TRPV1 activation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevents cisplatin ototoxicity by sustained increased activation of pro-survival transcription factor signal transducer and activator of transcription (STAT3) in the Wistar rat. Capsaicin 103-112 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 114-119 30676422-14 2019 By contrast, the TRPV1 agonist capsaicin (3 muM) produced a weaker potentiation in Withdrawn than Naive rats (spontaneous excitatory postsynaptic currents: by 203.6 +- 124.7% [n = 20] vs. 415.2 +- 424.3% [n = 15], P < 0.001; firing: 38.1 +- 14.7% [n = 11] vs. 73.9 +- 41.9% [n = 11], P < 0.001). Capsaicin 31-40 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 17-22 30676422-15 2019 Conversely, capsaicin"s actions in Naive but not in Withdrawn rats were significantly attenuated by the pretreatment of TRPV1 endogenous agonist N-Oleoyldopamine. Capsaicin 12-21 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-125 31138996-4 2019 TRPV1 agonist, capsaicin (CAP), was intraperitoneally administered. Capsaicin 15-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 30785813-0 2019 Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 30785813-3 2019 In the presence of capsazepine, a classic TRPV1 antagonist, capsaicin was still able to reduce spontaneous inhibitory postsynaptic current (IPSC) amplitude and frequency. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 30858408-1 2019 Capsaicin, the spicy component of hot chili peppers activates the TRPV1 pain receptors, and causes rapid desensitization. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-71 30858408-5 2019 Here we report that direct TRPV1 activation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevents cisplatin ototoxicity by sustained increased activation of pro-survival transcription factor signal transducer and activator of transcription (STAT3) in the Wistar rat. Capsaicin 103-112 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 30858408-7 2019 Our data indicate that capsaicin causes a transient STAT1 activation via TRPV1 activation, responsible for the previously reported temporary threshold shift. Capsaicin 23-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 73-78 30423807-1 2018 We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat. Capsaicin 21-30 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-100 30159798-10 2019 Possible molecular pathways of involvement of capsazepine (CPZ) and AM4040 in anandamide and capsaicin (CAP)-induced apoptosis, oxidative stress, and Ca2+ accumulation through TRPV1 channel in the seizure-induced rat hippocampus and human glioblastoma neurons. Capsaicin 93-102 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 176-181 30159798-10 2019 Possible molecular pathways of involvement of capsazepine (CPZ) and AM4040 in anandamide and capsaicin (CAP)-induced apoptosis, oxidative stress, and Ca2+ accumulation through TRPV1 channel in the seizure-induced rat hippocampus and human glioblastoma neurons. Capsaicin 104-107 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 176-181 30602263-5 2019 This indicates that vanilloid activators turn on the TRPV1 ion channel to transmit only pain and other nociceptive signals, while capsaicin and its competitive ligands are capable of activating intracellular G protein/PI3K/PIP2 signaling pathways by binding to endogenous cannabinoid receptors, and then increase intracellular PIP2 levels (the increasing PIP2 can competitively replace capsaicin and other vanilloid activators), thereby closing the TRPV1 channel and exerting the analgesic effect. Capsaicin 130-139 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 449-454 30094501-8 2019 The molecular docking study on the binding site of transient receptor potential vanilloid subtype 1 (TRPV1) has indicated that like capsaicin, eugenyloxy propanol azole analogues exhibited the strong affinity to bind at site of TPRV1 in a "tail-up, head-down" conformation and the presence of triazolyl moieties has played undeniable role in durable binding of these ligands to TRPV1. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-99 30094501-8 2019 The molecular docking study on the binding site of transient receptor potential vanilloid subtype 1 (TRPV1) has indicated that like capsaicin, eugenyloxy propanol azole analogues exhibited the strong affinity to bind at site of TPRV1 in a "tail-up, head-down" conformation and the presence of triazolyl moieties has played undeniable role in durable binding of these ligands to TRPV1. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 30094501-8 2019 The molecular docking study on the binding site of transient receptor potential vanilloid subtype 1 (TRPV1) has indicated that like capsaicin, eugenyloxy propanol azole analogues exhibited the strong affinity to bind at site of TPRV1 in a "tail-up, head-down" conformation and the presence of triazolyl moieties has played undeniable role in durable binding of these ligands to TRPV1. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 378-383 30583465-1 2018 Capsaicin is an agonist of the transient receptor potential vanilloid type 1 (TRPV1) channel, which has been related to the pathophysiology of kidney disease secondary to diabetes. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 31-76 30583465-1 2018 Capsaicin is an agonist of the transient receptor potential vanilloid type 1 (TRPV1) channel, which has been related to the pathophysiology of kidney disease secondary to diabetes. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 30809460-6 2019 Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release. Capsaicin 36-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-54 30576973-1 2019 Resiniferatoxin (RTX) is a daphnane diterpene isolated from the latex of Euphorbia resinifera O. Berg, a potent activator of transient receptor potential vanilloid 1 (TrpV1), with a potency 103-105 times greater than pure capsaicin. Capsaicin 222-231 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 167-172 30602263-2 2019 Capsaicin was used as a TRPV1 noxious ion channel activator to investigate the antagonism kinetics of six different substances on capsaicin. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 30602263-5 2019 This indicates that vanilloid activators turn on the TRPV1 ion channel to transmit only pain and other nociceptive signals, while capsaicin and its competitive ligands are capable of activating intracellular G protein/PI3K/PIP2 signaling pathways by binding to endogenous cannabinoid receptors, and then increase intracellular PIP2 levels (the increasing PIP2 can competitively replace capsaicin and other vanilloid activators), thereby closing the TRPV1 channel and exerting the analgesic effect. Capsaicin 130-139 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-58 30423807-1 2018 We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat. Capsaicin 21-30 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 102-107 30423807-1 2018 We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat. Capsaicin 32-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-100 30423807-1 2018 We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat. Capsaicin 32-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 102-107 29884534-3 2018 The most potent antagonist 6 not only exhibited potent antagonism of activation of hTRPV1 by capsaicin, low pH and elevated temperature but also displayed highly potent antagonism of activation of rTRPV1 by capsaicin. Capsaicin 207-216 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 197-203 30079821-6 2018 RESULTS: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocampus of rats with biliary cirrhosis. Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-55 30079821-6 2018 RESULTS: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocampus of rats with biliary cirrhosis. Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 157-162 30015706-4 2018 Studying the effect of complete Freund adjuvant (CFA)-induced inflammation on capsaicin-activated TRPV1 nociceptive responses in dorsal root ganglia (DRG), we found that CFA produced a large increase in capsaicin-induced responses. Capsaicin 78-87 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 30015706-4 2018 Studying the effect of complete Freund adjuvant (CFA)-induced inflammation on capsaicin-activated TRPV1 nociceptive responses in dorsal root ganglia (DRG), we found that CFA produced a large increase in capsaicin-induced responses. Capsaicin 203-212 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 30014177-1 2018 The TRPV1 channel is activated in neurons by capsaicin, oxidative stress, acidic pH and heat factors, and these factors are attenuated by the antioxidant role of calorie restriction (CR). Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 29959973-8 2018 In addition, GLP-1R knockdown elevated downstream TRPV1 expression and promoted capsaicin-induced TRPV1 function, which may regulate inhibitory neurotransmission to affect seizure susceptibility. Capsaicin 80-89 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 30374305-3 2018 We previously found that CAP can also be transported via TRPV1, which was site-specific in the permeability of CAP across the intestine. Capsaicin 25-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 30374305-3 2018 We previously found that CAP can also be transported via TRPV1, which was site-specific in the permeability of CAP across the intestine. Capsaicin 111-114 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 30138635-2 2018 The aim of this study was to evaluate the antidepressant-like properties of the TRPV1 agonist capsaicin using the forced swimming test (FST) in rats. Capsaicin 94-103 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-85 29427180-7 2018 In IgG192/LV-VR1-injected rats, the behavioral response to capsaicin exposure as well as Erk 1/2 phosphorylation and VR1 current activation by capsaicin were significantly reduced. Capsaicin 59-68 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-16 29352512-13 2018 SIGNIFICANCE: TRPV1 antagonists (of capsaicin activation) are highly unusual in that they can cause both hyper- and hypothermia by modulating the same mechanism. Capsaicin 36-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 29977195-3 2018 The present article explored this issue by assessing the effect of capsaicin, which activates C-fibers that express the transient receptor potential vanilloid receptor-1 (TRPV1). Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-169 29977195-3 2018 The present article explored this issue by assessing the effect of capsaicin, which activates C-fibers that express the transient receptor potential vanilloid receptor-1 (TRPV1). Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 171-176 29159769-6 2018 The study of intracellular signaling suggested that the transient receptor potential vanilloid 1 (TRPV1) and cannabinoid receptors in the soleus muscle were more sensitive to capsaicin. Capsaicin 175-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-96 29159769-6 2018 The study of intracellular signaling suggested that the transient receptor potential vanilloid 1 (TRPV1) and cannabinoid receptors in the soleus muscle were more sensitive to capsaicin. Capsaicin 175-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 29596901-6 2018 A sub-effective dose of NMDA (25 pmol) was potentiated by the TRPV1 receptor agonist capsaicin (CAP, 1 nmol) and the CB1 receptor antagonist, AM251 (200 pmol). Capsaicin 85-94 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-67 29740093-5 2018 On days 7&14 post-MIA, but not day 28, QX-314 + capsaicin signficantly attenuated changes in WB induced by MIA, illustrating a crucial role for TRPV1 expressing nociceptors in early OA pain. Capsaicin 48-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-149 29427180-7 2018 In IgG192/LV-VR1-injected rats, the behavioral response to capsaicin exposure as well as Erk 1/2 phosphorylation and VR1 current activation by capsaicin were significantly reduced. Capsaicin 143-152 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-16 29427180-7 2018 In IgG192/LV-VR1-injected rats, the behavioral response to capsaicin exposure as well as Erk 1/2 phosphorylation and VR1 current activation by capsaicin were significantly reduced. Capsaicin 143-152 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 117-120 29790024-1 2018 Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus. Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 137-142 29335353-6 2018 Moreover, intraplantar injection of TAT-31-50 attenuated the capsaicin-evoked spontaneous pain behavior and thermal hyperalgesia, which further strengthened the regulatory role of TAT-31-50 on TRPV1 channel. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 193-198 29304162-2 2018 Capsaicin is the most commonly used vanilloid to stimulate TRPV1. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-64 29275446-1 2018 BACKGROUND: Visceral pain is initiated by activation of primary afferent neurons among which the capsaicin-sensitive (TRPV1-positive) neurons play an important role. Capsaicin 97-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 118-123 29273526-9 2018 While the partly capsaicin-insensitive rabbit (o) TRPV1 fails to respond to AM404, AM404-sensitivity is restored by insertion of the capsaicin binding-domain of rat TRPV1 into oTRPV1. Capsaicin 17-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 165-170 29273526-9 2018 While the partly capsaicin-insensitive rabbit (o) TRPV1 fails to respond to AM404, AM404-sensitivity is restored by insertion of the capsaicin binding-domain of rat TRPV1 into oTRPV1. Capsaicin 133-142 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 165-170 28762564-1 2018 AIMS: This study was initiated to investigate the involvement of neutrophil leukocyte activation in neurogenic inflammation, a process also involved in human urinary pathologies, elicited in the rat urinary bladder by the local administration of capsaicin, the archetypal TRPV1 agonist. Capsaicin 246-255 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 272-277 28762564-10 2018 CONCLUSIONS: Topical application of capsaicin induces early neurogenically mediated cellular microcirculatory inflammatory reactions via the activation of the TRPV1 receptor and the release of CGRP and SP from sensory nerves in the bladder. Capsaicin 36-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 159-164 29304162-2 2018 Capsaicin is the most commonly used vanilloid to stimulate TRPV1. Capsaicin 36-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-64 29259542-0 2017 Capsaicin Enhances Glutamatergic Synaptic Transmission to Neonatal Rat Hypoglossal Motor Neurons via a TRPV1-Independent Mechanism. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-108 30078015-4 2018 METHODS: TRPV1 was activated or down-regulated by subcutaneous injection of a low (1mg/kg) or high (100mg/kg) dose of capsaicin, respectively, 3 hours before ischemia. Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-14 29259542-1 2017 We investigated whether capsaicin modulated synaptic transmission to hypoglossal motor neurons (HMNs) by acting on transient receptor potential vanilloid type 1 (TRPV1) receptors. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 115-160 29259542-1 2017 We investigated whether capsaicin modulated synaptic transmission to hypoglossal motor neurons (HMNs) by acting on transient receptor potential vanilloid type 1 (TRPV1) receptors. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 162-167 29259542-6 2017 The effect of capsaicin on excitatory synaptic transmission remained unchanged in the presence of the TRPV1 antagonists, capsazepine or SB366791, suggesting that capsaicin acts to modulate EPSCs via a mechanism which does not require TRPV1 activation. Capsaicin 162-171 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 102-107 29259542-6 2017 The effect of capsaicin on excitatory synaptic transmission remained unchanged in the presence of the TRPV1 antagonists, capsazepine or SB366791, suggesting that capsaicin acts to modulate EPSCs via a mechanism which does not require TRPV1 activation. Capsaicin 162-171 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 234-239 29035821-5 2017 The activation of TRPV1 receptors is achieved by administering capsaicin (CAP), the main TRPV1 agonist exerting a widely reported proepileptic effects. Capsaicin 63-72 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-23 29035821-5 2017 The activation of TRPV1 receptors is achieved by administering capsaicin (CAP), the main TRPV1 agonist exerting a widely reported proepileptic effects. Capsaicin 63-72 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-94 28861768-0 2017 Capsaicin Protects Against Oxidative Insults and Alleviates Behavioral Deficits in Rats with 6-OHDA-Induced Parkinson"s Disease via Activation of TRPV1. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 146-151 27832523-13 2017 The TRPV1 is also activated by mitochondrial oxidative stress and capsaicin, and it is blocked by capsazepine (CPZ). Capsaicin 66-75 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 28861768-6 2017 Both the expression of tyrosine hydroxylase and TRPV1 were increased in the striatal and substantia nigra areas of 6-OHDA induced rats after the treatment of capsaicin by the semi-quantitative analysis of Western Blot. Capsaicin 158-167 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 48-53 28251657-8 2017 Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-134 28687197-1 2017 Recently, we reported that capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, protected against excitotoxicity induced by intravitreal N-methyl-D-aspartic acid (NMDA) in the rats in vivo. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 40-84 28687197-1 2017 Recently, we reported that capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, protected against excitotoxicity induced by intravitreal N-methyl-D-aspartic acid (NMDA) in the rats in vivo. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 86-91 27730727-1 2017 Transient receptor potential vanilloid type 1 (TRPV1), the archetypal member of the vanilloid TRP family, was initially identified as the receptor for capsaicin, the pungent ingredient in hot chili peppers. Capsaicin 151-160 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 47-52 28838698-4 2017 Both compounds also proved to be very potent antagonists for rTRPV1, blocking in vivo the hypothermic action of capsaicin, consistent with their in vitro mechanism. Capsaicin 112-121 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-67 28622417-6 2017 Pre-exposure to isopetasin produced marked desensitization of allyl isothiocyanate (AITC, TRPA1 channel agonist)- or capsaicin (TRPV1 channel agonist)-evoked currents in rat TG neurons, contractions of rat or mouse bladder and CGRP release from mouse central terminals of primary sensory neurons. Capsaicin 117-126 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 128-133 28479337-8 2017 Trpv1 knock-out abolished the inhibitory effect of capsaicin on glutamate-induced calcium influx and subsequent neuronal death. Capsaicin 51-60 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 28479337-10 2017 In summary, our studies reveal that the neuroprotective effect of capsaicin in cortical neurons is TRPV1-dependent and down-regulation of the expression and function of NMDA receptors contributes to the protection afforded by capsaicin. Capsaicin 66-75 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 28251657-8 2017 Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 136-141 28522561-3 2017 First, a brief pretreatment with a low dose of TNFalpha (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Delta = 247%) immediately following the TNFalpha pretreatment, which gradually declined toward control and then increased again reaching another peak (Delta = 384%) after 60-90 min. Capsaicin 235-244 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-146 28522561-3 2017 First, a brief pretreatment with a low dose of TNFalpha (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Delta = 247%) immediately following the TNFalpha pretreatment, which gradually declined toward control and then increased again reaching another peak (Delta = 384%) after 60-90 min. Capsaicin 235-244 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 148-153 28062485-4 2017 In patch-clamp recordings with isolated rat vagal pulmonary sensory neurons, pretreatment with chloroquine (1-1,000 microM, 90 s) concentration dependently potentiated capsaicin-induced TRPV1-mediated inward currents. Capsaicin 168-177 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 186-191 28418433-7 2017 Together, these results suggest that capsaicin acts at TRPV1 present on hippocampal nerve terminals to increase calcineurin activation, which subsequently attenuates voltage-dependent Ca2+ entry to cause a decrease in evoked glutamate release. Capsaicin 37-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 27021021-15 2017 The TRPV1 channel is activated by oxidative stress and capsaicin, and it is blocked by capsazepine (CPZ). Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 28188777-5 2017 The data showed that the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) and the amplitudes of evoked excitatory postsynaptic currents (eEPSCs) were increased during morphine withdrawal after applied with capsaicin (TRPV1 agonist). Capsaicin 224-233 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 235-240 27774580-6 2017 TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin. Capsaicin 20-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 27774580-6 2017 TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin. Capsaicin 20-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 247-252 27774580-6 2017 TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin. Capsaicin 308-317 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 27774580-6 2017 TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin. Capsaicin 308-317 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 247-252 26957303-18 2017 The TRPV1 channel is activated by oxidative stress and capsaicin and it is blocked by capsazepine (CPZ). Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 28631948-4 2017 We demonstrated that ATP release and CBF were significantly potentiated by the heat-sensitive TRPV1 agonist capsaicin (10 muM), but not by other TRP agonists. Capsaicin 108-117 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 94-99 28418433-0 2017 Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 28475608-1 2017 TRPV1 (vanilloid) receptors are activated by different types of stimuli including capsaicin, acidification and heat. Capsaicin 82-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 28475608-4 2017 The APHCs potentiated TRPV1 responses to low (3-300 nM) concentrations of capsaicin but inhibited responses to high (>3.0 muM) concentrations. Capsaicin 74-83 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 28496430-11 2017 Both nicotine and carbachol induced intracellular Ca2+ transients in trigeminal neurons partially overlapping with expression of capsaicin-sensitive TRPV1 receptors. Capsaicin 129-138 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 149-154 28112976-5 2017 Compared to the control group, the group treated with capsaicin (TRPV1 agonist) had better scores in the PAL acquisition and retention test, whereas treatment with WIN55,212-2 (CB1/CB2 agonist) decreased the test scores. Capsaicin 54-63 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 65-70 28112976-7 2017 We conclude that the acute administration of a TRPV1 agonist improves the rats" cognitive performance in PAL tasks and that a vanilloid-related mechanism may underlie the agonistic effect of WIN55,212-2 on learning and memory. Capsaicin 126-135 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 47-52 27739618-3 2017 Prostaglandin E2 (PGE2) enriched in injured tissues is known not only directly to sensitize DRG neurons, but also to potentiate sensitizing effects of other pain mediators such as capsaicin and its receptor transient receptor potential vanilloid-1 (TRPV1). Capsaicin 180-189 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 249-254 27774580-10 2017 Taken together, we provide evidence that TRPV1 activation by capsaicin attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation during hypertension, which may be at least partly attributed to the suppression PI3K/Akt signaling pathway. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 28230360-8 2017 Analysis of the related genes suggested that the transient receptor potential vanilloid 1 (TRPV1) receptor was activated by capsaicin. Capsaicin 124-133 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-89 28230360-8 2017 Analysis of the related genes suggested that the transient receptor potential vanilloid 1 (TRPV1) receptor was activated by capsaicin. Capsaicin 124-133 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 28062485-7 2017 In summary, our study showed that activation of T2Rs augments capsaicin-evoked TRPV1 responses in rat pulmonary nociceptors through the phospholipase C and protein kinase C signaling pathway. Capsaicin 62-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 27900462-3 2017 We examined effects of capsaicin, a specific agonist of TRPV1 channels, on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats. Capsaicin 23-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-61 28097492-7 2017 The H2O2-induced TRPM2 current densities were decreased by N-(p-amylcinnamoyl)anthranilic acid (ACA), and dose-dependent capsaicin (CAP) and H2O2-induced TRPV1 currents were inhibited by capsazepine (CPZ). Capsaicin 132-135 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 154-159 28097492-8 2017 The TRPV1 channel is activated in the DRG neurons by 0.01 mM capsaicin but not 0.001 mM or 0.05 mM capsaicin. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 28225806-2 2017 Capsaicin is a specific transient receptor potential vanilloid 1 (TRPV1) agonist which was proved to ameliorate insulin resistance. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-64 28225806-2 2017 Capsaicin is a specific transient receptor potential vanilloid 1 (TRPV1) agonist which was proved to ameliorate insulin resistance. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-71 27710012-8 2017 The capsaicin-induced effects were inhibited by the TRPV1 antagonist capsazepine, amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonists CNQX, NBQX, perampanel, and riluzole, a drug that inhibits glutamate release and increases glutamate uptake. Capsaicin 4-13 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-57 27710012-10 2017 To summarize, capsaicin-induced apneas and seizure-like behaviors are mediated via TRPV1 activation acting at lung afferents, spinal cord-ascending tracts, and medullary structures (including nucleus tractus solitarius). Capsaicin 14-23 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 28133727-13 2017 In obese animals, dural application of the archetypal TRPV1 agonist capsaicin resulted in significantly augmented vasodilatory and vasoconstrictor responses as compared to controls. Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 27321307-10 2017 TRPV1 activation by measuring the increase in Ca2+ induced by capsaicin in dorsal root ganglia neurons. Capsaicin 62-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 27321307-14 2017 Capsaicin-induced calcium increase was higher in dorsal root ganglia cultures from PCS rats, indicating TRPV1functional increase. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 104-109 27900462-14 2017 The effects of capsaicin were partially blocked by TRPV1 antagonists but could be also induced at least partially via the non-specific action. Capsaicin 15-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-56 28848196-9 2017 In addition, capsaicin (a TRPV1 agonist) evokes a greater increase in the amplitude of AITC-currents in DRG neurons of ligated limbs than that in control limbs. Capsaicin 13-22 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 28637949-5 2017 This difference is due to the 8 chicken-specific amino acid residues around transmembrane 3, which is the main site of capsaicin-binding in rat TRPV1. Capsaicin 119-128 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-149 27614181-14 2016 In addition, treatment with a high dose of capsaicin in newborn rats, which induces degeneration of TRPV1-expressing sensory neurons, abolished both capsaicin and captopril-induced plasma extravasation in artificially ventilated rats. Capsaicin 43-52 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 100-105 27614181-14 2016 In addition, treatment with a high dose of capsaicin in newborn rats, which induces degeneration of TRPV1-expressing sensory neurons, abolished both capsaicin and captopril-induced plasma extravasation in artificially ventilated rats. Capsaicin 149-158 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 100-105 27872485-7 2016 DEX effectively reversed capsaicin and cumene hydroperoxide/ADP-ribose-induced TRPV1 and TRPM2 densities and cytosolic calcium ion accumulation in the neurons, respectively. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 27335281-5 2016 Intravenous injection of the TRPV1 agonist capsaicin produced hypotension and bradycardia in control rats, but this response was absent in TRPV1(-/-) rats. Capsaicin 43-52 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-34 27511837-6 2016 In all neurons investigated, 5HT potentiated capsaicin-evoked currents through TRPV1 channels, an effect that was attenuated by antagonists at 5HT2A (4 F 4 PP), 5HT2B (SB 204741), as well as 5HT2C (RS 102221) receptors. Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 27520401-8 2016 Intra-DLPAG administration of either the TRPV1 agonist capsaicin, or the TRPV1 antagonist 5"-Iodoresiniferatoxin (5"-IRTX), significantly increased formalin-evoked nociceptive behaviour in SD rats, but not in WKY rats. Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 27520401-9 2016 The effects of capsaicin were likely due to TRPV1 desensitisation, given their similarity to the effects of 5"-IRTX. Capsaicin 15-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-49 27671317-4 2016 Capsaicin, the specific TRPV1 agonist, dose-dependently reduced mitochondrial membrane potential and was blocked by the TRPV1 antagonist capsazepine or the calcineurin inhibitor cyclosporine. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 27671317-4 2016 Capsaicin, the specific TRPV1 agonist, dose-dependently reduced mitochondrial membrane potential and was blocked by the TRPV1 antagonist capsazepine or the calcineurin inhibitor cyclosporine. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-125 26526845-8 2016 At all developmental stages, TRPV1 activation with the selective agonist capsaicin increases glutamate release in the presence of tetrodotoxin, which blocks action potential-dependent and polysynaptic neurotransmission, indicating that functional TRPV1 fibers innervate SDCN neurons directly. Capsaicin 73-82 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-34 26526845-8 2016 At all developmental stages, TRPV1 activation with the selective agonist capsaicin increases glutamate release in the presence of tetrodotoxin, which blocks action potential-dependent and polysynaptic neurotransmission, indicating that functional TRPV1 fibers innervate SDCN neurons directly. Capsaicin 73-82 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 247-252 26526845-9 2016 Capsaicin-induced presynaptic glutamate release onto SDCN neurons depends on external Ca2+ influx through TRPV1 channels; voltage-dependent calcium channels had a slighter impact. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 106-111 26526845-10 2016 In contrast, capsaicin blocked C fiber-evoked synaptic transmission, indicating that TRPV1 activation has opposite effects on spontaneous asynchronous and action potential-dependent synchronous glutamate release. Capsaicin 13-22 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-90 26526845-12 2016 The opposite action of capsaicin on asynchronous and synchronous glutamate release should be taken into account when TRPV1 channels are considered as therapeutic targets. Capsaicin 23-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 117-122 26965218-7 2016 Administration of capsaicin (a TRPV1 agonist) into the RVM decreased nociceptive behavioural responses in the inflammatory phase of the formalin test (phase 2). Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 31-36 27342418-6 2016 Adriamycin treatment resulted in profound reductions in the cutaneous neurogenic sensory vasodilatation and plasma extravasation evoked by the TRPV1 and TRPA1 agonists capsaicin and mustard oil, respectively. Capsaicin 168-177 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 143-148 26099309-12 2016 The TRPV1 channel is activated by oxidative stress and capsaicin and it is blocked by capsazepine. Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 27439609-1 2016 BACKGROUND: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic compound. Capsaicin 70-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-189 27439609-8 2016 Olvanil was able to desensitise TRPV1 responses to further capsaicin exposure more effectively than capsaicin. Capsaicin 59-68 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 27439609-9 2016 Intraplantar injection of capsaicin (0.1, 0.3 and 1 mug) produced a robust TRPV1-dependant thermal hyperalgesia in rats, whilst olvanil (0.1, 0.3 and 1 mug) produced no hyperalgesia, emphasizing its lack of pungency. Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 75-80 27439609-1 2016 BACKGROUND: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic compound. Capsaicin 70-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 191-196 26970286-2 2016 METHODS: Sensitization of TRPV1 in MIA rats was assessed by transient spontaneous pain behavior induced by capsaicin injection in knee joints and electrophysiological changes of dorsal root ganglion (DRG) neurons innervating knee joints in response to capsaicin. Capsaicin 107-116 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 26970286-2 2016 METHODS: Sensitization of TRPV1 in MIA rats was assessed by transient spontaneous pain behavior induced by capsaicin injection in knee joints and electrophysiological changes of dorsal root ganglion (DRG) neurons innervating knee joints in response to capsaicin. Capsaicin 252-261 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 27382601-2 2016 Herpes simplex virus (HSV) vector expression of TRPV1 causes cell death in the presence of capsaicin, thereby completely blocking virus replication. Capsaicin 91-100 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 48-53 27143360-4 2016 The highly conserved tyrosine in position 511 (Tyr(511)) of the rat TRPV1 (rTRPV1) was the first residue to be identified as a necessary participant in the vanilloid-mediated response. Capsaicin 156-165 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 27143360-4 2016 The highly conserved tyrosine in position 511 (Tyr(511)) of the rat TRPV1 (rTRPV1) was the first residue to be identified as a necessary participant in the vanilloid-mediated response. Capsaicin 156-165 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 75-81 27052585-6 2016 In addition, spontaneous activity can be augmented with both the transient receptor potential cation channel subfamily V member 1 agonist capsaicin and the peptide bradykinin and completely blocked with neurokinin receptor antagonists. Capsaicin 138-147 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 65-129 26964685-5 2016 We found that warming induced an increase in miniature excitatory postsynaptic current (EPSC) frequency, which was blocked by the transient receptor potential vanilloid-1 (TRPV1) receptor antagonist AMG9810 and mimicked by its agonist capsaicin, suggesting that the synaptic effect is mediated by heat-sensitive TRPV1 channels. Capsaicin 235-244 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 172-177 26930003-5 2016 Calcium influx in response to the TRPA1 agonist allyl-isothiocyanate (AITC) (200 muM) and the TRPV1 stimulator capsaicin (330 nM) in rat trigeminal neurons or TRPA1 and TRPV1 receptor-expressing cell lines was measured by microfluorimetry or radioactive (45)Ca(2+) uptake experiments. Capsaicin 111-120 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 94-99 26902776-6 2016 We performed detailed functional characterization by means of electrophysiological whole-cell and single-channel recordings as well as Ca(2+)-imaging and challenged recombinant rTRPV1 receptors with capsaicin, low pH, or heat. Capsaicin 199-208 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 177-183 27177419-3 2016 Cryo-EM structures of TRPV1 and TRPV2 reveal that they adopt similar structures, and identify a putative vanilloid binding pocket near the internal side of TRPV1. Capsaicin 105-114 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 27177419-3 2016 Cryo-EM structures of TRPV1 and TRPV2 reveal that they adopt similar structures, and identify a putative vanilloid binding pocket near the internal side of TRPV1. Capsaicin 105-114 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 156-161 26970948-4 2016 Our results showed that the TRPV1 agonist, capsaicin, increased epileptic outcomes; whilst antagonizing TRPV1 with capsazepine exerts a protective role on paroxysmal discharge. Capsaicin 43-52 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 28-33 26724373-9 2016 Both a CB1 antagonist (AM251) and a TRPV1 agonist (Capsaicin; CPS) increased the expression of a conditioned emotional response. Capsaicin 51-60 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 36-41 26762784-4 2016 In our experiments, the TRPV1 agonist capsaicin evoked CGRP release and this was supressed by the TRPV1 antagonist capsazepine and by the opioid receptor agonist DAMGO. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 26762784-4 2016 In our experiments, the TRPV1 agonist capsaicin evoked CGRP release and this was supressed by the TRPV1 antagonist capsazepine and by the opioid receptor agonist DAMGO. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 26516054-8 2016 Noteworthy, Whirlin expression significantly reduced TRPV1 degradation induced by prolonged exposure to capsaicin. Capsaicin 104-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-58 26471418-5 2016 Activation of TRPV1 with capsaicin (100 nM) increased spontaneous EPSCs (sEPSCs) but inhibited ST-EPSCs. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 26909384-8 2016 The data are different from our previous evidence, where TRPA1 agonizts AITC and CA and TRPV1 agonist capsaicin produced hyperalgesia for nearly 2 h and resulted in facilitation of these withdrawal reflexes (Tsagareli et al., 2010, 2013). Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 88-93 26464396-3 2015 Here, we found that activation of transient receptor potential vanilloid subtype 1 (TRPV1) by capsaicin increased rat saliva secretion both in vivo and ex vivo. Capsaicin 94-103 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 34-82 29537196-7 2016 Further application of selective TRPA1 channel agonist (AITC) resulted in restoration of sensitivity to capsaicin TRPV1 channels ( resensitization TRPV1 channels). Capsaicin 104-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 114-119 29537196-7 2016 Further application of selective TRPA1 channel agonist (AITC) resulted in restoration of sensitivity to capsaicin TRPV1 channels ( resensitization TRPV1 channels). Capsaicin 104-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 147-152 26464396-3 2015 Here, we found that activation of transient receptor potential vanilloid subtype 1 (TRPV1) by capsaicin increased rat saliva secretion both in vivo and ex vivo. Capsaicin 94-103 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 26464396-9 2015 Furthermore, TRPV1 activation increased RhoA activity, and inhibition of either RhoA or Rho kinase (ROCK) abolished the capsaicin-induced TER decrease as well as ZO-1 and -2 redistribution. Capsaicin 120-129 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 26360139-11 2015 When an ineffective dose of the TRPV1 receptor antagonist 6-IODO was used, the capsaicin-induced increase in the cardiac baroreflex response was abolished. Capsaicin 79-88 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 26117090-10 2015 Activation of TRPV1 in the primary synoviocytes with capsaicin, a TRPV1 agonist, dose-dependently enhanced COX-2 transcription. Capsaicin 53-62 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 26117090-10 2015 Activation of TRPV1 in the primary synoviocytes with capsaicin, a TRPV1 agonist, dose-dependently enhanced COX-2 transcription. Capsaicin 53-62 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-71 26055306-12 2015 CONCLUSIONS: Decreased expression of TRPV1 and associated neuropeptide release contributed to the impaired capsaicin-induced vasodilation in diabetic mesenteric arteries. Capsaicin 107-116 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-42 25967571-6 2015 Activation of TRPV1 using capsaicin (1 microM) enhanced LTP induction in CA1 region in non-epileptic rats. Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 26283923-5 2015 Application of the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin to meninges dramatically increased firing whereas the amplitudes and shapes of spikes remained essentially unchanged. Capsaicin 76-85 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 19-59 26283923-5 2015 Application of the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin to meninges dramatically increased firing whereas the amplitudes and shapes of spikes remained essentially unchanged. Capsaicin 76-85 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 26283923-12 2015 Thus, the persistent activation of nociceptors in capsaicin-sensitive nerve fibers shown here may be involved in trigeminal pain signaling and plasticity along with the release of migraine-related neuropeptides from TRPV1 positive neurons. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 216-221 24706047-7 2015 All non-peptidergic and a third of peptidergic alpha7 nAChR-bearing nociceptors expressed TRPV1, a capsaicin-sensitive noxious stimulus transducer. Capsaicin 99-108 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-95 25618378-4 2015 The results showed that the lowest limit of detection of this biosensor to capsaicin was 1x10(-13) mol/L and the change rate of response current was the highest at the concentration of 9x10(-13) mol/L, indicating that the capsaicin receptor was saturated at this point. Capsaicin 75-84 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 222-240 25743251-7 2015 PTZ and CAP+PTZ administrations increased intracellular free Ca(2+) concentrations, TRPV1 current densities, apoptosis, caspase 3 and 9 values although the values were reduced by IRTX and CPZ treatments. Capsaicin 8-11 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 25843413-5 2015 In this study, we examined the hippocampal effects of co-administrating WIN55-212-2 and capsaicin, which are CB1 and TRPV1 agonists, respectively, on the induction of LTP in the dentate gyrus (DG) of rats. Capsaicin 88-97 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 117-122 25858491-4 2015 Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons. Capsaicin 222-231 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 146-151 25858491-4 2015 Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons. Capsaicin 233-236 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 146-151 25712904-7 2015 Notably, the excitation of isolated MNCs during hypertonicity is mediated by the activation of a capsaicin-insensitive cation channel that MNCs express as an N-terminal variant of the transient receptor potential vanilloid 1 (Trpv1) channel. Capsaicin 97-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 184-224 25712904-7 2015 Notably, the excitation of isolated MNCs during hypertonicity is mediated by the activation of a capsaicin-insensitive cation channel that MNCs express as an N-terminal variant of the transient receptor potential vanilloid 1 (Trpv1) channel. Capsaicin 97-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 226-231 25896608-5 2015 The inhibitory effects of capsaicin were calcium-dependent, and mediated by the capsaicin receptor (transient receptor potential vanilloid type-1). Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-145 25944998-10 2015 The effect of SGD on pain pressure threshold in these rats was abolished by activators of TRPV1 (capsaicin), TRPV4 (RN1747), TRPA1 (Polygodial) and PAR2 (AC55541). Capsaicin 97-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-95 25479918-10 2015 Although the TRPV1 agonist, capsaicin (100 nM) evoked no response at room temperature, it triggered cationic currents and [Ca(2+)]i elevation when the temperature was increased to 36 C. These results suggest that AVP neurones in the rat SON possess functional full-length TRPV1. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 25745388-0 2015 Identifying the integrated neural networks involved in capsaicin-induced pain using fMRI in awake TRPV1 knockout and wild-type rats. Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 25745388-4 2015 Capsaicin is an exogenous ligand for the TRPV1 receptor, and in wild-type rats, activated the putative pain neural circuit. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 25381485-2 2015 Results of recent reports indicated that EMR can increase temperature and oxidative stress of body cells, and TRPV1 channel is activated by noxious heat, oxidative stress, and capsaicin (CAP). Capsaicin 176-185 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 110-115 25479918-10 2015 Although the TRPV1 agonist, capsaicin (100 nM) evoked no response at room temperature, it triggered cationic currents and [Ca(2+)]i elevation when the temperature was increased to 36 C. These results suggest that AVP neurones in the rat SON possess functional full-length TRPV1. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 272-277 26109436-1 2015 BACKGROUND: The capsaicin and heat responsive ion channel TRPV1 is expressed on trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine attacks. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 58-63 25079903-3 2015 The open pore of capsaicin-activated TRPV1 channel admits organic molecules such as local anesthetics and we calculated that GBP entry via this route would be 500x more rapid than via the transporter. Capsaicin 17-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-42 25079903-6 2015 Under these conditions, capsaicin produced a capsazepine-sensitive inward current thereby confirming Q-GBP permeation of TRPV1 channels. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 121-126 25079903-11 2015 Capsaicin potentiation of GBP depression of dorsal horn activity may therefore reflect drug permeation of TRPV1 channels. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 106-111 25505315-4 2014 Here, using a combination of pharmacology, electrophysiology, and an in vivo knockdown strategy, we report that TRPV1 activation by capsaicin or by the endocannabinoid anandamide depresses somatic, but not dendritic inhibitory transmission in both rat and mouse dentate gyrus. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-117 25231620-8 2014 Finally, all neurons from both groups exhibited an inward current following exposure of the transient potential receptor vanilloid 1 (TRPV1) agonist, 8-methyl-N-vanillyl-6-nonenamide. Capsaicin 150-182 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 92-132 25231620-8 2014 Finally, all neurons from both groups exhibited an inward current following exposure of the transient potential receptor vanilloid 1 (TRPV1) agonist, 8-methyl-N-vanillyl-6-nonenamide. Capsaicin 150-182 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 134-139 25323897-1 2014 PURPOSE: Transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated nonselective cation channel, which can be activated by capsaicin and other noxious stimuli. Capsaicin 131-140 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-49 25371244-8 2014 These findings suggest that TRPA1 sensitization via TRPV1 signaling in TG neurons is involved in cold hyperalgesia following facial skin capsaicin injection. Capsaicin 137-146 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-57 25323897-1 2014 PURPOSE: Transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated nonselective cation channel, which can be activated by capsaicin and other noxious stimuli. Capsaicin 131-140 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-56 24468003-10 2014 Taken together, we propose that mithramycin-A directs an inhibitory effect on a subpopulation of capsaicin-responsive DRG neurons that utilize Sp1-like factors for TRPV1 expression. Capsaicin 97-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 164-169 25314299-6 2014 Although neuropeptide release caused by TRPV1 activation on sensory neurons elicits a cardioprotective effect, we found that capsaicin (CAP; a TRPV1 agonist) treatment of H9C2 cells paradoxically enhanced the level of apoptosis by increasing intracellular calcium and mitochondrial superoxide levels, attenuating mitochondrial membrane potential, and inhibiting mitochondrial biogenesis (measured by the expression of ATP synthase beta). Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 143-148 25314299-6 2014 Although neuropeptide release caused by TRPV1 activation on sensory neurons elicits a cardioprotective effect, we found that capsaicin (CAP; a TRPV1 agonist) treatment of H9C2 cells paradoxically enhanced the level of apoptosis by increasing intracellular calcium and mitochondrial superoxide levels, attenuating mitochondrial membrane potential, and inhibiting mitochondrial biogenesis (measured by the expression of ATP synthase beta). Capsaicin 136-139 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 143-148 24975423-0 2014 Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour. Capsaicin 54-63 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 39-44 24975423-1 2014 Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 36-76 24975423-1 2014 Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 24975423-1 2014 Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels. Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 167-172 24975423-9 2014 In conclusion, several neuroanatomical changes observed in capsaicin-treated rats, as well as the reduced cutaneous plasma extravasation responses, indicate that the role of TRPV1 channels in schizophrenia is worthy of investigation. Capsaicin 59-68 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 174-179 25104469-9 2014 Activation of TRPV1 or TRPV2 in distinct sets of primary afferents increased the sEPSC frequencies in a largely common population of DH neurons in laminae III-V, and might underlie the development of mechanical hypersensitivity following probenecid or capsaicin treatment. Capsaicin 252-261 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 24792079-2 2014 TRPV1 is a Ca(2+) permeable and non-selective channel, gated by noxious heat, oxidative stress and capsaicin (CAP). Capsaicin 99-108 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 24792079-2 2014 TRPV1 is a Ca(2+) permeable and non-selective channel, gated by noxious heat, oxidative stress and capsaicin (CAP). Capsaicin 110-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 24863039-0 2014 New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 24863039-2 2014 Since mu-opioid receptor (MOR) activation can inhibit the transient receptor potential vanilloid 1 (TRPV1) activity in peripherally sensory neurons, this study investigated the mechanisms of impaired opioid inhibitory effects on capsaicin-induced TRPV1 activity in painful diabetic neuropathy. Capsaicin 229-238 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 247-252 24863039-4 2014 In these animals, local morphine"s inhibitory effects on capsaicin-induced nocifensive behavior as well as on capsaicin-induced TRPV1 current in dorsal root ganglion cells were significantly impaired. Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 128-133 24863039-6 2014 Intrathecal delivery of nerve growth factor in diabetic animals normalized sensory neuron MOR and subsequently rescued morphine"s inhibitory effects on capsaicin-induced TRPV1 activity in vivo and in vitro. Capsaicin 152-161 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 170-175 24863039-7 2014 These findings identify a loss in functional MOR on sensory neurons as a contributing factor for the impaired opioid inhibitory effects on capsaicin-induced TRPV1 activity during advanced STZ-induced diabetes. Capsaicin 139-148 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 157-162 24676478-5 2014 Our results show that TRPV1 channels are not functional in insulin-secreting cells, since capsaicin did not produce current activation, not even under culture conditions known to induce the expression of other ion channels in these cells. Capsaicin 90-99 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 24704373-1 2014 Capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, has been reported to protect against ischemia-reperfusion injury in various organs, including the brain, heart, and kidney, whereas activation of TRPV1 was also reported to contribute to neurodegeneration, including pressure-induced retinal ganglion cell death in vitro. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-57 24704373-1 2014 Capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, has been reported to protect against ischemia-reperfusion injury in various organs, including the brain, heart, and kidney, whereas activation of TRPV1 was also reported to contribute to neurodegeneration, including pressure-induced retinal ganglion cell death in vitro. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-64 24704373-1 2014 Capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, has been reported to protect against ischemia-reperfusion injury in various organs, including the brain, heart, and kidney, whereas activation of TRPV1 was also reported to contribute to neurodegeneration, including pressure-induced retinal ganglion cell death in vitro. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 221-226 24746025-0 2014 Neonatal capsaicin treatment in rats affects TRPV1-related noxious heat sensation and circadian body temperature rhythm. Capsaicin 9-18 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 45-50 24746025-1 2014 The transient receptor potential vanilloid 1 (TRPV1) is a cation channel that serves as a polymodal detector of noxious stimuli such as capsaicin. Capsaicin 136-145 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-44 24746025-1 2014 The transient receptor potential vanilloid 1 (TRPV1) is a cation channel that serves as a polymodal detector of noxious stimuli such as capsaicin. Capsaicin 136-145 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 46-51 24746025-2 2014 Therefore, capsaicin treatment has been used to investigate the physiological function of TRPV1. Capsaicin 11-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-95 24746025-8 2014 Neonatal capsaicin treatment not only decreased TRPV1 expression but also induced desensitization to noxious heat stimuli. Capsaicin 9-18 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 48-53 24842665-8 2014 In cytosolic-free Ca(2+) analyses, the neurons were stimulated with the TRPV1 channel agonist capsaicin, a pungent compound found in hot chili peppers. Capsaicin 94-103 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 72-77 25135718-10 2014 (2) TRPV1 channel agonist, capsaicin, increased the Ca(2+) influx in a concentration-dependent manner (EC50=284.3+-58 nmol/L). Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 24792786-1 2014 Transient receptor potential vanilloid 1 (TRPV1) is a polymodal sensor that is activated by heat (>43 C), acid, or capsaicin, the pungent ingredient of hot peppers. Capsaicin 119-128 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 24962708-6 2014 Inflammatory stimuli stimulated actin polymerization and enhanced the response of the cation channel TRPV1 (transient receptor potential V1) to capsaicin in DRG neurons, effects that were reversed by the knockdown of LIMK or preventing cofilin phosphorylation. Capsaicin 144-153 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 24962708-6 2014 Inflammatory stimuli stimulated actin polymerization and enhanced the response of the cation channel TRPV1 (transient receptor potential V1) to capsaicin in DRG neurons, effects that were reversed by the knockdown of LIMK or preventing cofilin phosphorylation. Capsaicin 144-153 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 108-139 24598529-8 2014 Activation of TRPV1 with capsaicin (100 nM) increased miniature EPSC (mEPSC) frequency in 70% of neurons, but half of these neurons had Low basal mEPSC rates and no temperature sensitivity. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 24590823-0 2014 Inhibitory effects of capsaicin on voltage-gated potassium channels by TRPV1-independent pathway. Capsaicin 22-31 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-76 24590823-1 2014 Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-81 24590823-1 2014 Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 24590823-1 2014 Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats. Capsaicin 156-165 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 24590823-1 2014 Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats. Capsaicin 156-165 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 24590823-2 2014 It suggested that the inhibitory effects of capsaicin on IA have two different mechanisms: TRPV1-dependent and TRPV1-independent pathways. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 24590823-2 2014 It suggested that the inhibitory effects of capsaicin on IA have two different mechanisms: TRPV1-dependent and TRPV1-independent pathways. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-116 24590823-3 2014 The main purpose of this study is to further investigate the TRPV1-independent effects of capsaicin on voltage-gated potassium channels (VGPCs). Capsaicin 90-99 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 24590823-9 2014 These results suggest that capsaicin inhibits the VGPCs through TRPV1-independent and PKA-dependent mechanisms, which may contribute to the capsaicin-induced nociception. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 64-69 24569998-6 2014 Site-directed mutagenesis studies revealed that imperatorin most likely acted via a site adjacent to or overlapping with the TRPV1 capsaicin-binding site. Capsaicin 131-140 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-130 24548973-3 2014 Superfusion of the basilar artery with capsaicin, a selective TRPV1 receptor agonist, caused a transient relaxation, consistent with acute desensitization of neuronal TRPV1 channels. Capsaicin 39-48 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-67 24548973-3 2014 Superfusion of the basilar artery with capsaicin, a selective TRPV1 receptor agonist, caused a transient relaxation, consistent with acute desensitization of neuronal TRPV1 channels. Capsaicin 39-48 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 167-172 24056223-1 2013 We recently demonstrated that pain-sensing neurons in the trigeminal system can be selectively anesthetized by co-application of QX-314 with the TRPV1 receptor agonist, capsaicin (QX cocktail). Capsaicin 169-178 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 145-150 24699274-4 2014 Here, we report that inhalation of aerosolized 0.05% H2O2 for 90 s potentiated apneic responses to intravenous capsaicin (a TRPV1 receptor agonist), alpha,beta-methylene-ATP (a P2X receptor agonist), and phenylbiguanide (a 5-HT3 receptor agonist) in anesthetized rats. Capsaicin 111-120 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-129 24495935-4 2014 Capsaicin dose-dependently increased intracellular calcium with an EC50 of 0.29 muM in rTRPV1 expressing HEK293 cells. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-93 23722046-2 2013 Here, we first prepared nanovesicles containing rat pain sensory receptor, rat transient receptor potential vanilloid 1 (rTRPV1), which is activated by noxious heat and capsaicin. Capsaicin 169-178 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 121-127 24035514-2 2013 Among them, compound 24S showed stereospecific and excellent TRPV1 antagonism of capsaicin-induced activation. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 24217926-9 2014 Capsaicin (a TRPV1 agonist) evoked constrictions in skeletal muscle arteries and in the carotid artery, but had no effect on the femoral and mesenteric arteries or the aorta. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 24250792-10 2013 CONCLUSION AND IMPLICATIONS: Systemic capsaicin treatment of juvenile rats evokes anatomical and functional disappearance of the TRPV1-expressing neuronal cells but does not affect the TRPV1-expressing cells of the arterioles, implicating different effects of TRPV1 stimulation on the viability of these cell types. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 129-134 23913765-6 2013 Blockade of CaSR with its antagonists NPS 2390 and NPS 2143 significantly enhanced the capsaicin-evoked TRPV1 current. Capsaicin 87-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 104-109 23911956-2 2013 Thus, we investigated the abdominal nociception caused by peritoneal stimulation with TRPV1 (capsaicin) and TRPA1 (allyl isothiocyanate, AITC) agonists and their mechanisms in rats. Capsaicin 93-102 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 86-91 24147119-1 2013 The transient receptor potential vanilloid receptor 1 (TRPV1) channel is a nonselective cation channel activated by a variety of exogenous and endogenous physical and chemical stimuli, such as temperature (>=42 C), capsaicin, a pungent compound in hot chili peppers, and allyl isothiocyanate. Capsaicin 219-228 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 23916509-10 2013 In Ca(2+) imaging experiments, capsaicin, a TRPV1 agonist, induced a significant increase in intracellular calcium ion concentration ([Ca(2+)]i) in rat primary cultured VG neurons, which was almost completely blocked by capsazepine, a TRPV1-specific antagonist. Capsaicin 31-40 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-49 23916509-10 2013 In Ca(2+) imaging experiments, capsaicin, a TRPV1 agonist, induced a significant increase in intracellular calcium ion concentration ([Ca(2+)]i) in rat primary cultured VG neurons, which was almost completely blocked by capsazepine, a TRPV1-specific antagonist. Capsaicin 31-40 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 235-240 23919305-13 2013 After treatment with TRPV1 agonist capsaicin (CAP), [Ca(2+)]i was further increased, whereas [Ca(2+)]i was decreased after administration of TRPV1 antagonist capsazepine (CPZ) in ASMC of the asthmatic group. Capsaicin 35-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 23919305-13 2013 After treatment with TRPV1 agonist capsaicin (CAP), [Ca(2+)]i was further increased, whereas [Ca(2+)]i was decreased after administration of TRPV1 antagonist capsazepine (CPZ) in ASMC of the asthmatic group. Capsaicin 46-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 28664062-7 2013 2-APB dose-dependently potentiated rTRPV1 currents, that activated by capsaicin, protons, or noxious heat. Capsaicin 70-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-41 28664062-8 2013 2-APB potentiated the capsaicin-activated rTRPV1 current from both side of the patch membrane. Capsaicin 22-31 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-48 28664062-9 2013 A structural analogue of 2-APB, diphenylboronic anhydride, showed the same potentiation effect on the capsaicin-activated rTRPV1 current. Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-128 23911956-5 2013 TRPV1 antagonism prevented (94 +- 4% inhibition) nociception induced by capsaicin but not by AITC. Capsaicin 72-81 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 23911956-7 2013 Moreover, nociception induced by either capsaicin or AITC was reduced by the desensitisation of TRPV1-positive sensory fibres with resiniferatoxin (73 +- 18 and 76 +- 15% inhibitions, respectively) and by the NK1 receptor antagonist aprepitant (56 +- 5 and 53 +- 8% inhibitions, respectively). Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 23499799-2 2013 At high systemic doses (>125 mg/kg), capsaicin produces long-term changes in both tachykinin receptor and TRPV1 expression and function in rats. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 109-114 23384628-12 2013 CONCLUSIONS: The reflex apnea evoked by laryngeal CS requires activation of both TRPA1 and TRPV1 receptors, which are likely to be located at the terminals of superior laryngeal capsaicin-sensitive afferents. Capsaicin 178-187 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 23657286-3 2013 We examined the effect of the vanilloid compound zingerone, which activates TRPV1 channels in the cell body of a primary afferent neuron, on glutamatergic excitatory transmission in the SG neurons of adult rat spinal cord slices by using the whole cell patch-clamp technique. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 76-81 22982061-2 2013 Prolonged activation of TRPV1 by capsaicin leads to cell swelling and formation of membrane blebs in rat dorsal root ganglion (DRG) neurons. Capsaicin 33-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 23636721-7 2013 The TRPV1 receptor antagonist A-425619 abolished capsaicin-triggered currents and raised the threshold of heat-activated currents. Capsaicin 49-58 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 23384628-0 2013 Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats. Capsaicin 86-95 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-23 23384628-2 2013 The TRPA1 and TRPV1 receptors are two types of Ca(2+)-permeant channels located at the terminals of airway capsaicin-sensitive afferents. Capsaicin 107-116 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 23499799-3 2013 However, whether desensitising (low) doses of capsaicin (~50 mg/kg) affect tachykinin receptor and TRPV1 gene expression in the short term has yet to be investigated. Capsaicin 46-55 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 23499799-4 2013 The aim of the present study was to compare tachykinin receptor (NK1, NK2 and NK3) and TRPV1 mRNA expression 24h after administration of capsaicin (50 mg/kgs.c.). Capsaicin 137-146 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-92 23499799-7 2013 In the cervical spinal cord of rats treated with capsaicin, NK1 and NK3 mRNA expression were reduced by 56% and 80%, respectively (P<0.05), whereas NK2 and TRPV1 mRNA expression were increased 2.2- and 1.4-fold, respectively (P<0.05). Capsaicin 49-58 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 159-164 23499799-10 2013 In conclusion, these studies show that tachykinin receptor and TRPV1 mRNA expression undergo significant changes within 24h of systemic low-dose capsaicin administration. Capsaicin 145-154 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-68 23402980-0 2013 Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions. Capsaicin 77-86 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 16-21 23274964-2 2013 Capsaicin activation of TRPV1 is involved in enhancement of the expression of TRPV1 in mRNA and protein in dorsal root ganglion (DRG) in vivo. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 23274964-2 2013 Capsaicin activation of TRPV1 is involved in enhancement of the expression of TRPV1 in mRNA and protein in dorsal root ganglion (DRG) in vivo. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 23274964-6 2013 The percentage of PAR4-, TRPV1-immunoreactive neurons and their co-localization in cultured DRG neurons increased significantly in the presence of capsaicin as compared with that in the absence of capsaicin. Capsaicin 147-156 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 25-30 23274964-9 2013 Taken together, these results provide evidence that TRPV1 activation significantly increases the expression of PAR4 mRNA and protein levels in primary cultures of DRG neurons after capsaicin incubation. Capsaicin 181-190 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-57 23396520-4 2013 During whole-cell patch-clamp recording, endothelin-1 enhanced an induced current in response to capsaicin, a TRPV1 agonist, in approximately 20% of dissociated neurons. Capsaicin 97-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 110-115 23303863-2 2013 Coapplication of external QX-314 with the transient receptor potential vanilloid 1 protein (TRPV1) agonist capsaicin produces long-lasting sodium channel inhibition in TRPV1-expressing neurons, suggestive of QX-314 entry into the neurons. Capsaicin 107-116 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 92-97 23303863-2 2013 Coapplication of external QX-314 with the transient receptor potential vanilloid 1 protein (TRPV1) agonist capsaicin produces long-lasting sodium channel inhibition in TRPV1-expressing neurons, suggestive of QX-314 entry into the neurons. Capsaicin 107-116 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 168-173 23402980-5 2013 TRPV1 non-competitive antagonist ruthenium red significantly decreased the permeability of capsaicin in M-S direction across colonic membrane. Capsaicin 91-100 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 23402980-9 2013 Furthermore, TRPV1 might mediate the transport of capsaicin across the intestinal membrane. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 23402980-10 2013 Therefore, the colon-specific highest permeation of capsaicin could be the consequence of the colon-specific distribution of TRPV1. Capsaicin 52-61 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-130 22796104-1 2012 The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN). Capsaicin 35-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-114 23264033-6 2013 In response to heat activation or vanilloid treatment, Co(2+) accumulation was verified in TRPV1-transfected cell lines and in the TRPV1+ dorsal root ganglion neurons. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 23264033-6 2013 In response to heat activation or vanilloid treatment, Co(2+) accumulation was verified in TRPV1-transfected cell lines and in the TRPV1+ dorsal root ganglion neurons. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 131-136 23345400-6 2013 Capsazepine (CPZ), a TRPV1 antagonist, inhibited the capsaicin-induced occludin redistribution and TER decrease. Capsaicin 53-62 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 23345400-10 2013 Capsaicin also induced F-actin reorganization, which was abolished by CPZ, PD98059 and ML-7, indicating that TRPV1 activation altered F-actin organization in an ERK1/2- and MLC2-dependent manner. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 109-114 23201260-10 2013 Additionally, in a subpopulation of P2Xv/TRPV1 positive neurons, capsaicin-induced Ca(2+) transients were significantly amplified following P2X3 activation. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 23920479-1 2013 BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO). Capsaicin 92-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-80 23920479-1 2013 BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO). Capsaicin 92-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 82-87 23920479-1 2013 BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO). Capsaicin 146-155 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-80 23920479-1 2013 BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO). Capsaicin 146-155 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 82-87 23345400-11 2013 Furthermore, either PD98059 or ML-7 could abolish the capsaicin-induced TER response and occludin redistribution, whereas knockdown of ERK1/2 further confirmed that the TRPV1-modulated paracellular permeability was ERK1/2 dependent. Capsaicin 54-63 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 169-174 23340220-4 2013 This effect was independent of a functional endothelium but was blocked by the Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor antagonist SB366791 (2muM) or prolonged treatment with the TRPV1 agonist capsaicin (10muM). Capsaicin 215-224 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 126-131 23340220-4 2013 This effect was independent of a functional endothelium but was blocked by the Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor antagonist SB366791 (2muM) or prolonged treatment with the TRPV1 agonist capsaicin (10muM). Capsaicin 215-224 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 201-206 23283344-4 2013 Using tandem mass spectrometry we show that upon activation with capsaicin, QX-314 selectively accumulates in the cytosol only of TRPV1-expressing cells, and not in control cells. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 130-135 23283344-5 2013 Exposure to QX-314 and capsaicin induces in small DRG neurons a robust sodium current block within 30 s. In sciatic nerves, application of extracellular QX-314 with capsaicin persistently reduces C-fiber but not A-fiber compound action potentials and this effect does not occur in TRPV1(-/-) mice. Capsaicin 23-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 281-286 23283344-5 2013 Exposure to QX-314 and capsaicin induces in small DRG neurons a robust sodium current block within 30 s. In sciatic nerves, application of extracellular QX-314 with capsaicin persistently reduces C-fiber but not A-fiber compound action potentials and this effect does not occur in TRPV1(-/-) mice. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 281-286 23283344-6 2013 Behavioral phenotyping after selectively silencing TRPV1(+) sciatic nerve axons by perineural injections of QX-314 and capsaicin reveals deficits in heat and mechanical pressure but not pinprick or light touch perception. Capsaicin 119-128 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-56 23525210-1 2013 BACKGROUND: It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin 168-177 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-122 23525210-1 2013 BACKGROUND: It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors. Capsaicin 168-177 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-129 24162023-2 2013 TRPV1 is activated by multiple stimuli such as capsaicin, acid, and heat. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 23372735-7 2013 The TRPV-1 agonist capsaicin (Cap) induced an increase of I(SC), which was similar to the I(SC) induced by FA. Capsaicin 19-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-10 22982418-1 2012 AIMS: TRPV1-expressing, capsaicin (CAP)-sensitive afferent fibers innervating bladder in addition to sensory function also exhibit "efferent" features consisting in TRPV1-dependent release of tachykinins (TAC) affecting detrusor smooth muscle (DSM) contractions. Capsaicin 35-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 6-11 22982418-1 2012 AIMS: TRPV1-expressing, capsaicin (CAP)-sensitive afferent fibers innervating bladder in addition to sensory function also exhibit "efferent" features consisting in TRPV1-dependent release of tachykinins (TAC) affecting detrusor smooth muscle (DSM) contractions. Capsaicin 35-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 165-170 22796104-1 2012 The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN). Capsaicin 35-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 22796104-1 2012 The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN). Capsaicin 46-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-114 22796104-1 2012 The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN). Capsaicin 46-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 22820913-9 2012 Capsaicin- and 4alpha-PDD-induced calcium and migratory responses were inhibited by the selective TRPV1 and TRPV4 blockers, capsazepine and HC067047, respectively. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 22528458-1 2012 Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 174-214 22528458-1 2012 Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 216-221 23015437-5 2012 Whole-cell voltage-clamp recordings revealed that, in Gu-I, capsaicin-induced currents in layer 3 (L3) pyramidal cells (PCs) displayed no apparent desensitization, while those in layer 5 (L5) PCs displayed Ca(2+)-dependent desensitization, suggesting that L3 and L5 PCs respond differentially to TRPV1 activation. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 296-301 22820913-6 2012 Using microspectrofluorimetry (indo-1), we show that capsaicin and 4alpha-phorbol-12,13-didecanoate (4alpha-PDD), selective agonists of TRPV1 and TRPV4, respectively, increased the intracellular calcium concentration of PASMC. Capsaicin 53-62 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 136-141 22998799-5 2012 We previously identified MRS1477, a 1,4-dihydropyridine that potentiates vanilloid and pH activation of TRPV1 in vitro, but displays no detectable intrinsic agonist activity of its own. Capsaicin 73-82 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 104-109 22998799-10 2012 However, rats treated with the combination of capsaicin and MRS1477 exhibited increased withdrawal latency and decreased response intensity consistent with agonist potentiation and inactivation or lesion of TRPV1-containing nerve terminals. Capsaicin 46-55 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 207-212 22776418-7 2012 RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals. Capsaicin 19-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-143 22570364-5 2012 Although both classes of antagonists completely blocked capsaicin- and NADA-induced activation of TRPV1, select compounds only partially inhibited activation of the channel by protons. Capsaicin 56-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 22749994-2 2012 Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca(2+) entry and reactive oxygen species (ROS) production. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 81-86 22749994-6 2012 We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca(2+) entry through attenuating the activity of TRPV1. Capsaicin 90-99 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 157-162 22776418-7 2012 RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals. Capsaicin 19-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 145-150 22776418-7 2012 RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals. Capsaicin 207-216 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-143 22776418-7 2012 RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals. Capsaicin 207-216 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 145-150 22776418-8 2012 However, the postnatal capsaicin treatment prevented LPB-CeC synaptic potentiation after SNL, unlike in the vehicle-treated rats, primarily due to the decreased incidence of potentiated transmission by elimination of TRPV1-expressing C-fiber afferents. Capsaicin 23-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 217-222 22366261-5 2012 Grooming behavior after capsaicin injection into the whisker pad region was significantly increased after IAN transection and the increase in the behavior was reversed by systemic administration of a TRPV1 antagonist. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 200-205 22792028-0 2012 Capsaicin Blocks the Hyperpolarization-Activated Inward Currents via TRPV1 in the Rat Dorsal Root Ganglion Neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 22792028-6 2012 The capsaicin-induced inhibition of I(h) was prevented by preexposing the TRPV1 antagonist, capsazepine (CPZ). Capsaicin 4-13 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 74-79 22792028-8 2012 In summary, the inhibitory effects of capsaicin on I(h) are mediated by activation of TRPV1 and Ca(2+)-triggered cellular responses. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 86-91 22328719-5 2012 We found that, in rat dorsal root ganglion neurons, although DIDS did not induce the activation of TRPV1 per se but drastically increased the TRPV1 currents induced by either capsaicin or low pH. Capsaicin 175-184 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 142-147 22532967-1 2012 Capsaicin, an activator of the transient potential vanilloid receptor type 1 (TRPV1), is a commonly used pharmacological tool for desensitising sensory nerves. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-83 22532967-2 2012 Capsaicin can induce vasorelaxation of isolated blood vessels by activating perivascular TRPV1 receptors, causing the release of vasoactive neuropeptides. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-94 22532967-12 2012 In summary,we have identified a potential mechanism underlying TRPV1-independent capsaicin-induced vasorelaxation. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-68 22314222-10 2012 These results suggest that histamine-induced vasoconstriction and long-lasting vasodilation are mediated by activation of TRPV1 on capsaicin-sensitive and capsaicin-insensitive nerves. Capsaicin 131-140 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 22314222-10 2012 These results suggest that histamine-induced vasoconstriction and long-lasting vasodilation are mediated by activation of TRPV1 on capsaicin-sensitive and capsaicin-insensitive nerves. Capsaicin 155-164 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 22466126-4 2012 METHODS: Activation of the TRPV1 receptor with capsaicin was studied with patch clamp methods in acutely isolated small-diameter rat sensory neurons in primary culture. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 22466126-6 2012 RESULTS: Neurons isolated from lumbar DRGs 3 days after local inflammation showed enhanced TRPV1 function: tachyphylaxis (the decline in response to repeated applications of capsaicin) was significantly reduced. Capsaicin 174-183 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 22627148-4 2012 Synaptic transmission between DRG and DH neurons was stimulated by capsaicin, which activates transient receptor potential vanilloid-1 (TRPV1) receptors on small diameter DRG neurons. Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 94-134 22627148-4 2012 Synaptic transmission between DRG and DH neurons was stimulated by capsaicin, which activates transient receptor potential vanilloid-1 (TRPV1) receptors on small diameter DRG neurons. Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 136-141 22215506-0 2012 Differential effects of acute hypoxia on the activation of TRPV1 by capsaicin and acidic pH. Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-64 22215506-13 2012 The differential effects of hypoxia on I (TRPV1,Cap) and I (TRPV1,Acid) suggested that the intracellular ROS increase might attenuate the pharmacological potency of capsaicin. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 22215506-13 2012 The differential effects of hypoxia on I (TRPV1,Cap) and I (TRPV1,Acid) suggested that the intracellular ROS increase might attenuate the pharmacological potency of capsaicin. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-65 22215506-4 2012 Such changes were also suggested from hypoxia- and capsaicin-induced Ca(2+) signals in TRPV1-expressing cells. Capsaicin 51-60 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-92 22209919-2 2012 Peripherally released 5HT induces thermal hyperalgesia, possibly via modulation of the transient receptor potential V1 (TRPV1) channel, which is gated by various noxious stimuli, including capsaicin. Capsaicin 189-198 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-118 22209919-2 2012 Peripherally released 5HT induces thermal hyperalgesia, possibly via modulation of the transient receptor potential V1 (TRPV1) channel, which is gated by various noxious stimuli, including capsaicin. Capsaicin 189-198 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-125 22264228-0 2012 Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia. Capsaicin 23-32 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 22215714-1 2012 Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism. Capsaicin 240-249 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 22215714-1 2012 Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism. Capsaicin 240-249 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 226-231 22264228-3 2012 METHODS: B(1)R expression (mRNA, protein and binding sites) was measured in cervical, thoracic and lumbar spinal cord in response to TRPV1 activation by systemic capsaicin (1-50 mg/kg, s.c) in rats pre-treated with TRPV1 antagonists (capsazepine or SB-366791), the antioxidant N-acetyl-L-cysteine (NAC), or vehicle. Capsaicin 162-171 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 133-138 22108615-7 2012 In accord with these findings, quantitative RT-PCR revealed a marked and significant recovery in TRPV1 mRNA after perineural capsaicin but not after nerve transection. Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 97-102 22108615-0 2012 Disparate changes in the expression of transient receptor potential vanilloid type 1 receptor mRNA and protein in dorsal root ganglion neurons following local capsaicin treatment of the sciatic nerve in the rat. Capsaicin 159-168 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 39-93 22108615-1 2012 In situ hybridization, quantitative reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry, and Western blot analysis were applied to study the changes in expression of the major nociceptive ion channel transient receptor potential vanilloid type 1 receptor (TRPV1) after the perineural application of capsaicin or nerve transection. Capsaicin 326-335 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 227-281 22108615-3 2012 After either transection or capsaicin treatment of the sciatic nerve, immunohistochemistry and Western blotting demonstrated a massive (up to 80%) decrease in the proportion of TRPV1-immunoreactive neurons and TRPV1 protein at all postoperative survival times. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 177-182 22108615-3 2012 After either transection or capsaicin treatment of the sciatic nerve, immunohistochemistry and Western blotting demonstrated a massive (up to 80%) decrease in the proportion of TRPV1-immunoreactive neurons and TRPV1 protein at all postoperative survival times. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 210-215 22108615-9 2012 The present findings imply that the antinociceptive and anti-inflammatory effects of perineurally applied capsaicin involve distinct changes in neuronal TRPV1 mRNA expression and long-lasting alterations in (post)translational regulation. Capsaicin 106-115 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 153-158 22274646-5 2012 Capsazepine, a specific antagonist of TRPV1, completely blocked the capsaicin- and AM404-induced [Ca (2+)]i increases. Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 38-43 21998141-8 2012 In contrast, agonists for TRPV1 (capsaicin), TRPV3 (camphor), or TRPV4 (alpha-PDD) rarely induced an increase in the membrane conductance of PASMCs. Capsaicin 33-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 21928164-2 2012 Capsaicin is reported to trigger calcitonin gene-related peptide (CGRP) release through activation of transient receptor potential vanilloid subfamily member 1 (TRPV1) and produces beneficial effects on gastric mucosa. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 161-166 22510966-6 2012 The vasodilatation, but not vasoconstriction, in response to anandamide was markedly attenuated by capsazepine [selective antagonist for transient receptor potential vanilloid-1 (TRPV1)], pretreatment with capsaicin [calcitonin gene-related peptide (CGRP)ergic-nerve depletor], or cold-storage denervation. Capsaicin 206-215 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 137-177 22514663-8 2012 A significant subset of neurons responded to capsaicin (CAP), a TRPV1 agonist, although neurons from C57BL/6 were 10-fold more sensitive to CAP than SD rats or BalbC mice, and a significantly smaller fraction of neurons from BalbC mice responded to CAP. Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 64-69 22962595-2 2012 In this study we hypothesized that the level of QX-314/capsaicin (QX-CAP)--induced blockade of nocifensive behavior could be used as an indirect in-vivo measurement of functional expression of TRPV1 channels. Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 193-198 22514663-8 2012 A significant subset of neurons responded to capsaicin (CAP), a TRPV1 agonist, although neurons from C57BL/6 were 10-fold more sensitive to CAP than SD rats or BalbC mice, and a significantly smaller fraction of neurons from BalbC mice responded to CAP. Capsaicin 56-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 64-69 21930676-5 2011 In our experiments, sodium acetate (20 mm), which was used to induce intracellular acidosis, attenuated the capsaicin-evoked TRPV1 current (I(CAP)) in a reversible manner in whole-cell patch-clamp mode and shifted the concentration-response curve to the right. Capsaicin 108-117 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-130 22025666-8 2011 Stimulation of the TRPv1 receptor by injection of capsaicin into the arterial supply of the hindlimb evoked significantly larger elevations in MAP and RSNA in SHR compared to WKY. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 19-24 21867704-5 2011 The TRPV1 agonist capsaicin (CAPS, 1 muM) and the TRPA1 agonist allyl isothiocyanate (AITC, 30 muM), elicited excitatory effects in bladder strips, increasing basal tone and amplitude of phasic bladder contractions (PBC). Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 21232043-8 2011 Effects of capsaicin were antagonized by SB 366791, a TRPV1 channel antagonist. Capsaicin 11-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 21621010-6 2011 Heat and capsaicin-evoked responses were both blocked by TRPV1 antagonist, capsazepine. Capsaicin 9-18 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 21904821-1 2011 We studied the inhibitory effects of transient receptor potential vanilloid-1 (TRPV1) activation by capsaicin on low-voltage-activated (LVA, T-type) Ca(2+) channel and high-voltage-activated (HVA; L, N, P/Q, R) currents in rat DRG sensory neurons, as a potential mechanism underlying capsaicin-induced analgesia. Capsaicin 100-109 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-77 21904821-1 2011 We studied the inhibitory effects of transient receptor potential vanilloid-1 (TRPV1) activation by capsaicin on low-voltage-activated (LVA, T-type) Ca(2+) channel and high-voltage-activated (HVA; L, N, P/Q, R) currents in rat DRG sensory neurons, as a potential mechanism underlying capsaicin-induced analgesia. Capsaicin 100-109 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 21904821-6 2011 The percentage of T-type and HVA channel inhibition was prevented by replacing Ca(2+) with Ba(2+) during capsaicin application or applying high doses of intracellular BAPTA (20 mM), suggesting that TRPV1-mediated inhibition of T-type and HVA channels is Ca(2+)-dependent and likely confined to membrane nano-microdomains. Capsaicin 105-114 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 198-203 21852608-0 2011 Activation of transient receptor potential vanilloid 1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats. Capsaicin 66-75 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-54 21852608-3 2011 We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp). Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-151 21852608-3 2011 We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp). Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 153-158 21852608-15 2011 CONCLUSIONS: Activation of TRPV1 channels by dietary capsaicin mediated increases in phosphorylation of eNOS and could represent a novel target for dietary intervention of stroke. Capsaicin 53-62 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 21737202-2 2011 Trigeminal pain can be triggered by activation of the transient receptor potential V1 channel (TRPV1), expressed by a subset of nociceptive trigeminal ganglia (TG) neurons and gated by capsaicin, noxious heat, and other noxious stimuli. Capsaicin 185-194 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 95-100 21737202-3 2011 As 5HT is released in the periphery during inflammation and evokes thermal hyperalgesia, and TRPV1 is essential for thermal hyperalgesia, we hypothesized that 5HT increases the activity of capsaicin-sensitive trigeminal neurons and that this increase can be attenuated by pharmacologically targeting peripheral 5HT receptors. Capsaicin 189-198 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-98 21232043-1 2011 BACKGROUND AND PURPOSE: Capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1) channels, is pro-nociceptive in the periphery but is anti-nociceptive when administered into the ventrolateral periaqueductal gray (vlPAG), a midbrain region for initiating descending pain inhibition. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-89 21232043-1 2011 BACKGROUND AND PURPOSE: Capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1) channels, is pro-nociceptive in the periphery but is anti-nociceptive when administered into the ventrolateral periaqueductal gray (vlPAG), a midbrain region for initiating descending pain inhibition. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 21232043-9 2011 CONCLUSIONS AND IMPLICATIONS: Capsaicin activated TRPV1s on glutamatergic terminals to release glutamate which activated postsynaptic mGlu5 receptors, yielding 2-AG from DAG by DAGL hydrolysis. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-55 21232043-12 2011 This is a novel TRPV1 channel-mediated anti-nociceptive mechanism in the brain and a new interaction between vanilloid and endocannabinoid systems. Capsaicin 109-118 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 16-21 21329730-2 2011 In the spinal cord, capsaicin significantly reduced TRPV1 and SP-ir (40-45%) in laminae I/II compared to controls, while RTX produced decreases of ~35%. Capsaicin 20-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-57 21364497-1 2011 BACKGROUND AND OBJECTIVES: Capsaicin selectively binds to TRPV1, the vanilloid subtype 1 of the superfamily of transient receptor potential ion channels, which is highly expressed in pain-transmitting C fibers. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 58-63 21364497-2 2011 Recent reports have demonstrated that the coadministration of capsaicin with a local anesthetic (LA) at the rat sciatic nerve elicits a prolonged nociceptive-selective nerve block, suggesting that activation of the TRPV1 receptor may allow LAs to enter the nerve through the TRPV1 pore. Capsaicin 62-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 215-220 21364497-2 2011 Recent reports have demonstrated that the coadministration of capsaicin with a local anesthetic (LA) at the rat sciatic nerve elicits a prolonged nociceptive-selective nerve block, suggesting that activation of the TRPV1 receptor may allow LAs to enter the nerve through the TRPV1 pore. Capsaicin 62-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 275-280 21364497-13 2011 CONCLUSIONS: This study demonstrates that the combined application of amitriptyline and capsaicin results in prolonged cutaneous analgesia compared with amitriptyline alone, suggesting that the activation of the TRPV1 channel by capsaicin facilitates the passage of amitriptyline into nociceptors. Capsaicin 88-97 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 212-217 21364497-13 2011 CONCLUSIONS: This study demonstrates that the combined application of amitriptyline and capsaicin results in prolonged cutaneous analgesia compared with amitriptyline alone, suggesting that the activation of the TRPV1 channel by capsaicin facilitates the passage of amitriptyline into nociceptors. Capsaicin 229-238 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 212-217 21527011-8 2011 Most IBA-responding neurons (71%) also responded to the TRPV1 agonist capsaicin, indicating that they were nociceptors. Capsaicin 70-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-61 21329730-7 2011 These data suggest that stimulation of TRPV1 by low dose vanilloid administration can rapidly (within 24h) alter both transcription and translation of TRPV1 channels, SP and NK1 receptors in the rat urinary bladder and spinal cord. Capsaicin 57-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 39-44 21329730-7 2011 These data suggest that stimulation of TRPV1 by low dose vanilloid administration can rapidly (within 24h) alter both transcription and translation of TRPV1 channels, SP and NK1 receptors in the rat urinary bladder and spinal cord. Capsaicin 57-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 151-156 21146075-3 2011 In vitro studies conducted with cultures of rat trigeminal neurons demonstrated that pretreatment with LPS produced a significant increase in the capsaicin-evoked release of calcitonin gene-related peptide (CGRP) when compared with vehicle pretreatment, thus showing sensitization of the capsaicin receptor, TRPV1, by LPS. Capsaicin 146-155 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 288-306 21098091-5 2011 Although AS1928370 inhibited the capsaicin-induced Ca2(+) flux in human and rat TRPV1-expressing cells, the inhibitory effect on proton-induced Ca2(+) flux was extremely small. Capsaicin 33-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-85 21115034-7 2011 Nevertheless, it was reduced in presence of capsazepine (10 or 20 mg/kg, s.c.) suggesting the participation of the TRPV1 receptor, which was reinforced when hesperidin significantly reduced the capsaicin-induced nociceptive response. Capsaicin 194-203 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 115-120 21114980-7 2011 Pretreatment with capsazepine, a TRPV1 antagonist, significantly decreased capsaicin-evoked EMG activity in both streptozotocin-treated and control rats. Capsaicin 75-84 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-38 21448716-4 2011 We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX). Capsaicin 157-166 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-89 21448716-4 2011 We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX). Capsaicin 157-166 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-89 21448716-7 2011 Additionally, the binding mode of a simplified RTX (sRTX) ligand as predicted by the modeling agreed well with those of capsaicin and RTX, accounting for the high binding affinity of the sRTX ligand for TRPV1. Capsaicin 120-129 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 203-208 21156986-0 2011 Capsaicin indirectly suppresses voltage-gated Na+ currents through TRPV1 in rat dorsal root ganglion neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 67-72 21156986-10 2011 CONCLUSION: The findings suggest that capsaicin decreases both TTX-s and TTX-r INa(+) as a result of an increase in [Na(+)]i through TRPV1. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 133-138 21725760-1 2011 Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-53 21725760-1 2011 Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 21725760-2 2011 Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-85 21146075-3 2011 In vitro studies conducted with cultures of rat trigeminal neurons demonstrated that pretreatment with LPS produced a significant increase in the capsaicin-evoked release of calcitonin gene-related peptide (CGRP) when compared with vehicle pretreatment, thus showing sensitization of the capsaicin receptor, TRPV1, by LPS. Capsaicin 146-155 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 308-313 21954707-0 2011 [Changes the TRPV1-immunoreactive neurons of the rat spinal nerve sensory ganglia induced by capsaicin]. Capsaicin 93-102 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 21954707-3 2011 Capsaicin treatment of newborn rats was shown to change age dynamics of TRPV1-positive neurons resulting in the reduction of the average cell cross-sectional area and cell numbers during the whole period of observation. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 72-77 21430411-0 2011 Effects of systemic capsaicin treatment on TRPV1 and Tachykinin NK(1) receptor distribution and function in the nucleus of the solitary tract of the adult rat. Capsaicin 20-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-48 21430411-2 2011 We have previously shown that systemic capsaicin administration to neonatal rats evokes profound long-term alterations in transient receptor potential vanilloid 1 (TRPV1)- and neurokinin 1 (NK(1)) receptor-mediated respiratory responses in the commissural nucleus of the solitary tract (cNTS). Capsaicin 39-48 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 164-169 21949835-7 2011 The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 21949835-7 2011 The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-61 21949835-7 2011 The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-61 21949835-7 2011 The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-61 21949835-9 2011 Since TRPV1 mediates asynchronous release following TRPV1+ ST-evoked EPSCs, we likewise found that recruiting more than one ST afferent further augmented the asynchronous response and was eliminated by capsaicin. Capsaicin 202-211 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 6-11 21167052-1 2010 BACKGROUND: Ablation of TRPV1-expressing nociceptive fibers with the potent capsaicin analog resiniferatoxin (RTX) results in long lasting pain relief. Capsaicin 76-85 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 20576527-2 2010 In vivo activation of TRPV1 receptors by natural agonists like capsaicin is associated with a sharp and burning pain, frequently described as pungency. Capsaicin 63-72 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 20826151-7 2010 These results indicate that visceral hypersensitivity induced by TRPV1 activation is modulated through 5-HT pathways and the attenuated function of TRPV1 and decreased protein expression of pCaMKII may play an important role in capsaicin-induced TRPV1 desensitization under 5-HT-depleted condition. Capsaicin 228-237 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 65-70 20826151-7 2010 These results indicate that visceral hypersensitivity induced by TRPV1 activation is modulated through 5-HT pathways and the attenuated function of TRPV1 and decreased protein expression of pCaMKII may play an important role in capsaicin-induced TRPV1 desensitization under 5-HT-depleted condition. Capsaicin 228-237 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 148-153 20643195-2 2010 The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia. Capsaicin 181-190 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 204-244 20643195-2 2010 The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia. Capsaicin 181-190 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 246-251 20643195-9 2010 The similar pattern and magnitude of Fos-LI after capsaicin suggested that TRPV1-responsive trigeminal nerves that supply intraocular and ocular surface tissues form a unified integrative circuit in the caudal brainstem. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 75-80 20331538-3 2010 Therefore, this study was undertaken to delineate the actions of PBG on respiration and compared with those evoked by capsaicin (TRPV1 agonist). Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 129-134 20538089-10 2010 Capsaicin, an agonist activator of the vanilloid nociceptors (TRPV1), appears to be effective in protecting bone from arthritic damage. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-67 20016958-7 2010 Results support the idea that capsaicin may interact with the transduction pathways of sweet and bitter taste stimuli, possibly in mediation of its receptor VR1 localized in taste receptor cells. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 157-160 20826151-7 2010 These results indicate that visceral hypersensitivity induced by TRPV1 activation is modulated through 5-HT pathways and the attenuated function of TRPV1 and decreased protein expression of pCaMKII may play an important role in capsaicin-induced TRPV1 desensitization under 5-HT-depleted condition. Capsaicin 228-237 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 148-153 20621685-4 2010 In vitro studies showed that capsaicin-evoked TRPV1-dependent CGRP release was 54.7+/-7.7% higher in OA, relative to levels measured for naive rats, suggesting that TRPV1 activity was higher under OA conditions. Capsaicin 29-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 46-51 20566388-4 2010 Intraplantar capsaicin, a TRPV1 channel agonist, was used to induce neurogenic inflammation in anesthetized rats that were pretreated intrathecally (i.t. Capsaicin 13-22 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 20728216-7 2010 Subpopulations of cells that exhibited the hypercapnic acidosis-induced Ca(2+) response also responded to the application of capsaicin (TRPV1 agonist) and menthol (TRPM8 agonist). Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 136-141 20621685-4 2010 In vitro studies showed that capsaicin-evoked TRPV1-dependent CGRP release was 54.7+/-7.7% higher in OA, relative to levels measured for naive rats, suggesting that TRPV1 activity was higher under OA conditions. Capsaicin 29-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 165-170 20383941-8 2010 The inhibitory role of the selective alpha2 adrenoreceptor agonist clonidine on capsaicin-evoked SP release may be through decreasing VR1 mRNA levels then reducing the sensitivity of nociceptors to capsaicin. Capsaicin 80-89 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 134-137 20561904-3 2010 MAIN METHODS: We used a behavioral rat model of capsaicin-induced trigeminal thermal hyperalgesia, intranasal CO2 application and several pharmacologic agents such as carbonic anhydrase, acid-sensing ion channels (ASICs), and TRPV1 blocker as well as acidic buffer solutions to investigate and mimic the underlying mechanism. Capsaicin 48-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 226-231 20123014-1 2010 Capsaicin, the hot chemical in chillies, administered to neonatal rats, causes destruction of polymodal nociceptive primary afferent neurons by acting on TRPV1 receptors causing intrinsic somatosensory deprivation. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 154-159 20123014-3 2010 In the present study the effect of neonatal capsaicin treatment on brain receptors that have been shown to interact with TRPV1 was examined. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 121-126 20414199-3 2010 Molecular determinants of TRPV1 activation by capsaicin, allicin, acid, ammonia and voltage have been identified. Capsaicin 46-55 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 19800272-0 2010 Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 41-46 19800272-7 2010 In conclusion, using measurement of threshold temperatures eliciting nocifensive reactions in rats both in the hot and cold range revealed that capsaicin and RTX impair thermosensation in both noxious ranges due to a functional desensitization of peripheral terminals of TRPV1-expressing sensory neurons responsible for noxious heat and cold responsiveness. Capsaicin 144-153 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 271-276 20427129-3 2010 In control cultures, capsaicin resulted in the activation of TRPV1 in 29.7+/-2.5% of the neurons, as assessed with the cobalt uptake assay. Capsaicin 21-30 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 20197082-2 2010 Systemic capsaicin treatment destroys gastric vagal afferent neurons expressing vanilloid receptor 1 (VR1). Capsaicin 9-18 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-100 20197082-2 2010 Systemic capsaicin treatment destroys gastric vagal afferent neurons expressing vanilloid receptor 1 (VR1). Capsaicin 9-18 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 102-105 20197082-6 2010 The numbers of VR1-immunoreactive neurons projecting to the stomach were significantly reduced 10 days after either capsaicin treatment or vagotomy. Capsaicin 116-125 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 15-18 20197082-7 2010 However, the VR1-immunoreactive afferent innervation of the stomach was restored to levels exceeding those of vagotomized rats by 37 days after capsaicin, whereas neither total afferent innervation nor VR1-immunoreactive innervation reached control levels, even by 67 days after vagotomy. Capsaicin 144-153 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-16 20335377-6 2010 Capsaicin was used to activate TRPV1. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 31-36 20335377-11 2010 UTP, a P2Y purinoceptor 2 (P2Y(2))/P2Y(4) receptor agonist, reversed capsaicin-induced TRPV1 desensitization. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-92 20307063-1 2010 The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a nonselective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Capsaicin 180-189 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-70 20307063-1 2010 The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a nonselective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Capsaicin 180-189 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 72-77 20145248-4 2010 In the presence of saturating capsaicin, rat TRPV1 (rTRPV1) reaches full activation, with no further stimulation by protons. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 45-50 20145248-4 2010 In the presence of saturating capsaicin, rat TRPV1 (rTRPV1) reaches full activation, with no further stimulation by protons. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-58 20145248-7 2010 By analysis of chimeric channels between hTRPV1 and rTRPV1, we found that transmembrane domain 1-4 (TM1-4) of TRPV1 determines whether protons can further open the fully capsaicin-bound receptors. Capsaicin 170-179 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-58 20036240-0 2010 The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 74-80 20036240-2 2010 Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activation of the protein kinase C (PKC) cascade. Capsaicin 98-107 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-58 20036240-4 2010 In a rat model of acute neurogenic inflammatory pain produced by capsaicin injection, we used immunofluorescence and Western blots combined with pharmacology and surgical sympathectomies to analyze whether the capsaicin-evoked up-regulation of TRPV(1) in DRG neurons is affected by sympathetic outflow by way of activating the PKC cascade. Capsaicin 210-219 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 244-250 20036240-5 2010 Sympathetic denervation reduced significantly the capsaicin-evoked expressions of TRPV(1), calcitonin gene-related peptide and/or phosphorylated PKC and their co-expression. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 82-89 20036240-9 2010 Our findings suggest that the capsaicin-evoked up-regulation of TRPV(1) receptors in DRG neurons is modulated sympathetically by the action of ATP released from sympathetic efferents to activate the PKC cascade. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 64-70 19958765-6 2010 Treatment of rTRPV1-expressing cells with sphinomyelinase inhibited the capsaicin-evoked (45)Ca-uptake leaving the RTX-induced response unchanged. Capsaicin 72-81 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-19 20107070-3 2010 TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin). Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 19399481-8 2010 Exposure to pollutants increased the TRPV1, NK(1) and NK(2) receptors gene expression in bronchus, an effect was partially suppressed by capsaicin treatment. Capsaicin 137-146 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-42 20107070-3 2010 TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin). Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 20639627-3 2010 Perfusion of capsaicin (CAP, 10(-6)M), a selective TRPV1 agonist, into the left renal pelvis increased ipsilateral ARNA in all groups, but with a smaller magnitude in DS-HS compared to other groups. Capsaicin 13-22 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-56 19818386-2 2010 This study examines whether TNF-alpha modulates the capsaicin-induced effects after transient receptor potential vanilloid (TRPV)-1 receptor activation on voltage activated calcium channel currents (I(Ca(V))). Capsaicin 52-61 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 84-131 19818386-5 2010 Pre-application of TNF-alpha (100 ng/ml) for 24h results in a sensitization of I(Ca(V)) to capsaicin (0.1 microM) with a reduction of 42.8+/-4.4% mediated by TRPV-1. Capsaicin 91-100 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 158-164 20639627-3 2010 Perfusion of capsaicin (CAP, 10(-6)M), a selective TRPV1 agonist, into the left renal pelvis increased ipsilateral ARNA in all groups, but with a smaller magnitude in DS-HS compared to other groups. Capsaicin 24-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-56 19628632-8 2009 Conversely, contractile responses to ET-1 were, compared with PHE, hypersensitive to the relaxing effects of the TRPV1-agonist capsaicin and to exogenous CGRP, but not to acetylcholine, forskolin, pinacidil, or SNP. Capsaicin 127-136 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 113-118 19778582-1 2009 The transient receptor potential (TRP) vanilloid type 1 (TRPV1) agonist, capsaicin, enhances glutamatergic spontaneous excitatory synaptic transmission in CNS neurons. Capsaicin 73-82 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 19778582-8 2009 RTX activity could be blocked by capsazepine or SB-366791, a TRPV1 antagonist, but not tetrodotoxin, a Na(+)-channel blocker, and could be inhibited by pretreatment with capsaicin but not the TRPA1 agonist, allyl isothiocyanate. Capsaicin 170-179 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 20162407-4 2009 Capsaicin and low pH induced significant increases in CGRP release which was shown to be mediated by TRPV1 activation as demonstrated with the TRPV1 antagonists CTPC and capsazepine. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 20162407-4 2009 Capsaicin and low pH induced significant increases in CGRP release which was shown to be mediated by TRPV1 activation as demonstrated with the TRPV1 antagonists CTPC and capsazepine. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 143-148 19773532-9 2009 These data demonstrate that E(2) mediates the female"s enhanced sensitivity to capsaicin-induced acute pain, consistent with potentiation by E(2) of the capsaicin receptor-mediated current in rat DRG neurons. Capsaicin 79-88 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 153-171 20407214-7 2010 The TRPV1 agonist capsaicin increased melatonin secretion from perifused pineals in a dose-dependent manner that was blocked by the competitive TRPV1 antagonist capsazepine. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 20407214-7 2010 The TRPV1 agonist capsaicin increased melatonin secretion from perifused pineals in a dose-dependent manner that was blocked by the competitive TRPV1 antagonist capsazepine. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-149 19948377-10 2010 These putative TRPV1-expressing C-fibers are sensitized to heat and acid after incision, and the transduction of heat and chemical stimuli after plantar incision is impaired by dilute capsaicin. Capsaicin 184-193 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 15-20 19537933-8 2010 The antagonism of the capsaicin and proton action on native TRPV1 by MCS-18 may be of interest for pain therapy. Capsaicin 22-31 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-65 19860742-9 2009 TRPV1 antagonist, capsazepine (10 microM) abolished capsaicin-evoked ATP release, and reduced acid-evoked (pH 6.5) release to 30% (P < 0.001). Capsaicin 52-61 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 19860742-12 2009 CONCLUSIONS AND IMPLICATIONS: Capsaicin (at TRPV1) and acid (at both TRPV1 and ASIC) induce ATP release from the rat bladder mucosa. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-49 19860742-12 2009 CONCLUSIONS AND IMPLICATIONS: Capsaicin (at TRPV1) and acid (at both TRPV1 and ASIC) induce ATP release from the rat bladder mucosa. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 19767149-2 2009 For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation by capsaicin and heat. Capsaicin 176-185 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 8-52 19767149-2 2009 For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation by capsaicin and heat. Capsaicin 176-185 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 19464796-5 2009 Pretreatment of the muscle with a TRPV1 antagonist, capsazepine, effectively attenuated the capsaicin-induced muscle nociception and mechanical hyperalgesia. Capsaicin 92-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 34-39 19298229-6 2009 capsazepine, the selective TRPV1 antagonist SB-705498, neomycin or vehicle alone and 30 min later instilled with intracolonic TRPV1-activating capsaicin. Capsaicin 143-152 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 126-131 19622238-4 2009 Real-time RT-PCR analysis revealed decreased expression of sweet receptors T1R2 and T1R3 as well as capsaicin receptor VR1 in the circumvallate after this repeated oral exposure to capsaicin. Capsaicin 100-109 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 119-122 19622238-7 2009 Also, these data suggest that capsaicin may interact with a sweet transduction pathway in the mediation of its receptor VR1 that are located in the vallate taste cells. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 120-123 19286963-1 2009 In rats, hindlimb muscle ischemia induced by femoral artery occlusion augments the sympathetic nervous response to stimulation of transient receptor potential vanilloid type 1 (TRPV1) by injection of capsaicin into the arterial blood supply of the hindlimb muscles. Capsaicin 200-209 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 130-175 19539789-0 2009 N-arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents via activation of TRPV1 receptors. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 97-102 19539789-1 2009 We investigated the effect of N-arachidonyl dopamine (NADA), an endogenous agonist of both transient receptor potential vanilloid 1 (TRPV1) and cannabinoid CB1 receptors, on the sensitivity of rat capsaicin-sensitive lung vagal afferent (CSLVA) fibers. Capsaicin 197-206 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-131 19362118-2 2009 Recent findings demonstrated that the rat dura mater is innervated by trigeminal capsaicin-sensitive peptidergic nociceptive afferent nerves which mediate meningeal vascular responses through activation of the transient receptor potential vanilloid type 1 (TRPV1) receptor. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 210-255 19362118-2 2009 Recent findings demonstrated that the rat dura mater is innervated by trigeminal capsaicin-sensitive peptidergic nociceptive afferent nerves which mediate meningeal vascular responses through activation of the transient receptor potential vanilloid type 1 (TRPV1) receptor. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 257-262 19404626-7 2009 Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation. Capsaicin 84-93 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 118-123 19404626-7 2009 Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation. Capsaicin 84-93 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 168-173 19236908-7 2009 Capsazepine (10 microM), a TRPV1 receptor antagonist, abolished the effect of capsaicin on mEPSCs. Capsaicin 78-87 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 19457767-10 2009 The elevation of SP mRNA, VR1 mRNA, and VR1 protein promoted by NGF and/or butyrate may be associated with increases of SP release evoked by capsaicin. Capsaicin 141-150 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 40-43 19286963-1 2009 In rats, hindlimb muscle ischemia induced by femoral artery occlusion augments the sympathetic nervous response to stimulation of transient receptor potential vanilloid type 1 (TRPV1) by injection of capsaicin into the arterial blood supply of the hindlimb muscles. Capsaicin 200-209 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 177-182 19158342-6 2009 The TRPV1 agonist capsaicin (1-100 microM) and the TRPA1/TRPM8 agonist menthol (5-200 microM) elicited transient currents in a moderate percentage of cells ( approximately 25%). Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 19174160-3 2009 Heat and capsaicin activate TRPV1 but not TRPV4 in yeast. Capsaicin 9-18 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 28-33 19202316-6 2009 These effects of capsaicin were inhibited by pretreatment with capsazepine, a transient receptor potential vanilloid receptor 1 (TRPV1) competitive antagonist. Capsaicin 17-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-127 18752301-1 2009 A recent study by our group demonstrates pharmacologically that the transient receptor potential vanilloid-1 (TRPV(1)) is activated by intradermal injection of capsaicin to initiate neurogenic inflammation by the release of neuropeptides in the periphery. Capsaicin 160-169 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-108 18752301-1 2009 A recent study by our group demonstrates pharmacologically that the transient receptor potential vanilloid-1 (TRPV(1)) is activated by intradermal injection of capsaicin to initiate neurogenic inflammation by the release of neuropeptides in the periphery. Capsaicin 160-169 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 110-117 18752301-3 2009 Capsaicin injection into the hindpaw skin of anesthetized rats evoked increases in the expression of TRPV(1), CGRP and p-PKC in mRNA and/or protein levels and in the number of single labeled TRPV(1), p-PKC, and CGRP neurons in ipsilateral L4-5 DRGs. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-108 18752301-3 2009 Capsaicin injection into the hindpaw skin of anesthetized rats evoked increases in the expression of TRPV(1), CGRP and p-PKC in mRNA and/or protein levels and in the number of single labeled TRPV(1), p-PKC, and CGRP neurons in ipsilateral L4-5 DRGs. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 191-198 18752301-6 2009 Taken together, these results provide evidence that up-regulation of TRPV(1) mRNA and protein levels under inflammatory conditions evoked by capsaicin injection is subject to modulation by the PKC cascade in which increased CGRP level in DRG neurons may be related to the initiation of neurogenic inflammation. Capsaicin 141-150 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-76 19202316-6 2009 These effects of capsaicin were inhibited by pretreatment with capsazepine, a transient receptor potential vanilloid receptor 1 (TRPV1) competitive antagonist. Capsaicin 17-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 129-134 18996081-1 2008 Transient receptor potential vanilloid 1 (TRPV1) functions as a polymodal nociceptor and is activated by several vanilloids, including capsaicin, protons and heat. Capsaicin 135-144 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-40 18839149-5 2009 Intravenous administration of the TRPV1 antagonist, capsazepine (3 mg/kg), significantly reduced the excitatory reflex response to capsaicin. Capsaicin 131-140 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 34-39 19152548-1 2009 Stimulation of primary sensory neurons with capsaicin or mustard oil leads to phosphorylation of extracellular signal-regulated protein kinase 1/2 (p-ERK1/2) via activation of transient receptor potential V1 (TRPV1) or TRPA1, respectively. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 176-207 19152548-1 2009 Stimulation of primary sensory neurons with capsaicin or mustard oil leads to phosphorylation of extracellular signal-regulated protein kinase 1/2 (p-ERK1/2) via activation of transient receptor potential V1 (TRPV1) or TRPA1, respectively. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 209-214 19152548-8 2009 From the present results, it may be assumed that capsaicin- or mustard oil-induced p-ERK1/2 in sensory neurons is not solely directly linked to TRPV1 or TRPA1 channels, but under certain conditions NK(1)- and NK(2)-mediated mechanisms are involved. Capsaicin 49-58 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-149 19012737-7 2009 In RTX-treated or dorsal rhizotomized rats, capsaicin still increased the frequency of spontaneous excitatory post-synaptic currents and miniature excitatory post-synaptic currents in the majority of neurons examined, and this effect was abolished by a TRPV1 blocker or by non-NMDA receptor antagonist. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 253-258 19096234-2 2009 In sensory neurons of rat embryos, dorsal root ganglion (DRG) in culture, nefopam (3-30 mumol/l) and capsazepine (TRPV1 antagonist, 10 mumol/l) prevented intracellular calcium elevation and calcitonin gene-related peptide release induced by vanilloid agonist capsaicin. Capsaicin 259-268 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 114-119 18996081-1 2008 Transient receptor potential vanilloid 1 (TRPV1) functions as a polymodal nociceptor and is activated by several vanilloids, including capsaicin, protons and heat. Capsaicin 135-144 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 18996081-4 2008 Capsaicin induced severe neuronal death with apoptotic features, which was completely inhibited by the TRPV1 antagonist capsazepine and was dependent on extracellular Ca(2+) influx. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-108 18695637-5 2008 The potentiation by PEA and OEA was endothelium-independent and abolished by treatment with capsaicin (10 microM), which desensitizes the transient receptor potential vanilloid type 1 (TRPV1) receptor system, or by the TRPV1 receptor antagonist, N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791) (2 microM). Capsaicin 92-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 138-183 19085565-2 2008 Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsaicin, resiniferatoxin, and protons. Capsaicin 99-108 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-40 19085565-2 2008 Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsaicin, resiniferatoxin, and protons. Capsaicin 99-108 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 18701354-3 2008 The present study assessed the role of calcitonin gene-related peptide (CGRP) in sensitization of primary afferent nociceptors induced by activation of transient receptor potential vanilloid-1 (TRPV(1)) after intradermal injection of capsaicin and determined if this release is due to activation of primary afferent neurons antidromically by triggering of DRRs. Capsaicin 234-243 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 152-192 18701354-3 2008 The present study assessed the role of calcitonin gene-related peptide (CGRP) in sensitization of primary afferent nociceptors induced by activation of transient receptor potential vanilloid-1 (TRPV(1)) after intradermal injection of capsaicin and determined if this release is due to activation of primary afferent neurons antidromically by triggering of DRRs. Capsaicin 234-243 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 194-201 18701354-8 2008 Capsaicin injection evoked increases in numbers of single and double labeled TRPV(1) and CGRP neurons in ipsilateral dorsal root ganglia (DRG). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-84 19014578-3 2008 As CAP is a potent agonist of the transient receptor potential vanilloid receptor 1 (TRPV1) and no information was available of its expression in germ cells, we also studied the presence of TRPV1 in the cultured cells and in germ cells in situ. Capsaicin 3-6 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 34-83 19014578-3 2008 As CAP is a potent agonist of the transient receptor potential vanilloid receptor 1 (TRPV1) and no information was available of its expression in germ cells, we also studied the presence of TRPV1 in the cultured cells and in germ cells in situ. Capsaicin 3-6 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-90 18632800-0 2008 TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 18632800-3 2008 We tested the hypothesis that the excitation of capsaicin-sensitive primary afferent fibers arising from the uterus through the stimulation of transient receptor potential vanilloid 1 (TRPV1) induces cross-organ sensitization on the pelvic-urethra reflex activity. Capsaicin 48-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 143-183 18632800-3 2008 We tested the hypothesis that the excitation of capsaicin-sensitive primary afferent fibers arising from the uterus through the stimulation of transient receptor potential vanilloid 1 (TRPV1) induces cross-organ sensitization on the pelvic-urethra reflex activity. Capsaicin 48-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 185-190 18632800-5 2008 Activation of capsaicin-sensitive primary afferent fibers by capsaicin instillation into the uterine horn sensitized the pelvic-urethra reflex activity that was reversed by an intrauterine pretreatment with capsaizepine, a TRPV1-selective antagonist. Capsaicin 14-23 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 223-228 18632800-5 2008 Activation of capsaicin-sensitive primary afferent fibers by capsaicin instillation into the uterine horn sensitized the pelvic-urethra reflex activity that was reversed by an intrauterine pretreatment with capsaizepine, a TRPV1-selective antagonist. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 223-228 18632800-7 2008 These results demonstrated that TRPV1 plays a crucial role in contributing to the capsaicin-sensitive primary afferent fibers mediating the glutamatergic NMDA-dependent cross-organ sensitization between the uterus and the lower urinary tract when there is a tissue injury. Capsaicin 82-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 18617618-0 2008 17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient receptor potential vanilloid receptor 1 activation by capsaicin in adult rat nociceptor neurons. Capsaicin 138-147 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 74-123 18617618-3 2008 Here, we show that 17beta-estradiol acts directly on dorsal root ganglion (DRG) sensory neurons to reduce TRPV1 activation by capsaicin. Capsaicin 126-135 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 106-111 18617618-4 2008 Capsaicin-induced cobalt uptake and the maximum TRPV1 current induced by capsaicin were inhibited when isolated cultured DRGs neurons from adult female rats were exposed to 17beta-estradiol (10-100 nm) overnight. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 48-53 18617618-4 2008 Capsaicin-induced cobalt uptake and the maximum TRPV1 current induced by capsaicin were inhibited when isolated cultured DRGs neurons from adult female rats were exposed to 17beta-estradiol (10-100 nm) overnight. Capsaicin 73-82 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 48-53 18617618-6 2008 Diarylpropionitrile (ERbeta agonist) also inhibited capsaicin-induced TRPV1 currents, whereas propylpyrazole triol (ERalpha agonist) and 17alpha-estradiol (inactive analog) were inactive, and 17beta-estradiol conjugated to BSA (membrane-impermeable agonist) caused a small increase. Capsaicin 52-61 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-75 18829846-1 2008 TRPV1 receptors are activated and/or modulated by noxious heat, capsaicin, protons and other endogenous agents released following tissue injury. Capsaicin 64-73 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 18832423-9 2008 In conclusion, allergen-induced airway inflammation clearly elevated capsaicin sensitivity in myelinated pulmonary afferents, which probably resulted from an increased expression of TRPV1 in these sensory nerves. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 182-187 19112407-7 2008 The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin. Capsaicin 163-172 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 31-34 19112407-7 2008 The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin. Capsaicin 163-172 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-47 19112407-7 2008 The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin. Capsaicin 163-172 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-47 18809416-0 2008 Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Capsaicin 74-83 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 19-24 18809416-8 2008 These findings suggest that the activation of NK-1R by its agonist, by sensitizing the TRPV1 through the PKC phosphorylation of TRPV1, may play a role in the enhancement of the capsaicin-evoked SP release from cultured rat DRG neurons. Capsaicin 177-186 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-92 18809416-8 2008 These findings suggest that the activation of NK-1R by its agonist, by sensitizing the TRPV1 through the PKC phosphorylation of TRPV1, may play a role in the enhancement of the capsaicin-evoked SP release from cultured rat DRG neurons. Capsaicin 177-186 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 128-133 18695637-5 2008 The potentiation by PEA and OEA was endothelium-independent and abolished by treatment with capsaicin (10 microM), which desensitizes the transient receptor potential vanilloid type 1 (TRPV1) receptor system, or by the TRPV1 receptor antagonist, N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791) (2 microM). Capsaicin 92-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 185-190 18695637-5 2008 The potentiation by PEA and OEA was endothelium-independent and abolished by treatment with capsaicin (10 microM), which desensitizes the transient receptor potential vanilloid type 1 (TRPV1) receptor system, or by the TRPV1 receptor antagonist, N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791) (2 microM). Capsaicin 92-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 219-224 18826653-1 2008 The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamide, and phosphorylation by protein kinase C (PKC). Capsaicin 4-13 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-89 18755179-3 2008 A robust increase in intracellular Ca(2+) was elicited by a variety of TRPV1 agonists with similar rank order of potency between both cultures: resiniferatoxin>tinyatoxin>capsaicin>N-arachidonoyl-dopamine (NADA). Capsaicin 177-186 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-76 18722504-1 2008 Local application of alphabetaMeATP (ligand for P2X3 receptors) and capsaicin (ligand for TRPV1 receptors) to the rat hindpaw produces pain behaviors (flinching) which are enhanced by noradrenaline (NA). Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-95 18838811-2 2008 TRPV1 activation by the intake of capsaicin, the irritant in hot pepper, induces adrenaline secretion and increases energy consumption. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 18973552-0 2008 Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons. Capsaicin 84-93 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 75-80 18826653-1 2008 The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamide, and phosphorylation by protein kinase C (PKC). Capsaicin 4-13 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-96 18826653-7 2008 Mutagenesis of rat TRPV1 revealed that DAG-binding site is at Y511, the same site for capsaicin binding, and PtdIns(4,5)P2binding site may not be critical for the activation of rat TRPV1 by DAG in heterologous system. Capsaicin 86-95 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 19-24 18588953-7 2008 In [(3)H]endomorphin-1 binding assays, capsazepine antagonized the inhibitory effect of capsaicin in rat brain membranes suggesting the involvement of TRPV1 receptors. Capsaicin 88-97 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 151-156 18660449-5 2008 Muscle vascular insufficiency was induced by the femoral artery ligation in rats for 24 h. Our data show that 1) the ligation surgery leads to the upregulation of TRPV1 expression in the dorsal root ganglion; 2) the magnitude of the dorsal root ganglion neuron TRPV1 response induced by capsaicin is greater in vascular insufficiency (4.0 +/- 0.31 nA, P < 0.05 vs. sham-operated control) than that in sham-operated control (2.9 +/- 0.23 nA); and 3) renal sympathetic nerve activity and mean arterial pressure responses to capsaicin (0.5 microg/kg body wt) are also enhanced by vascular insufficiency (54 +/- 11%, 9 +/- 2 mmHg in sham-operated controls vs. 98 +/- 13%, 33 +/- 5 mmHg after vascular insufficiency, P < 0.05). Capsaicin 287-296 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 163-168 18660449-5 2008 Muscle vascular insufficiency was induced by the femoral artery ligation in rats for 24 h. Our data show that 1) the ligation surgery leads to the upregulation of TRPV1 expression in the dorsal root ganglion; 2) the magnitude of the dorsal root ganglion neuron TRPV1 response induced by capsaicin is greater in vascular insufficiency (4.0 +/- 0.31 nA, P < 0.05 vs. sham-operated control) than that in sham-operated control (2.9 +/- 0.23 nA); and 3) renal sympathetic nerve activity and mean arterial pressure responses to capsaicin (0.5 microg/kg body wt) are also enhanced by vascular insufficiency (54 +/- 11%, 9 +/- 2 mmHg in sham-operated controls vs. 98 +/- 13%, 33 +/- 5 mmHg after vascular insufficiency, P < 0.05). Capsaicin 525-534 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 163-168 18777111-1 2008 The vanilloid receptor 1 (TRPV1) is activated by capsaicin, several endogenous lipids, acidic pH and elevated temperatures. Capsaicin 49-58 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-24 18777111-1 2008 The vanilloid receptor 1 (TRPV1) is activated by capsaicin, several endogenous lipids, acidic pH and elevated temperatures. Capsaicin 49-58 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 18777111-4 2008 Focal application of heated solutions demonstrated that the normal threshold (approximately 42 degrees C) of TRPV1 activation was reduced in the presence of capsaicin (1 microM) to approximately 30 degrees C. In current-clamp recordings, increasing the temperature of the solution resulted in larger membrane depolarizations and significantly altered the pattern and onset of the action potential train evoked by 1 microM capsaicin. Capsaicin 157-166 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 109-114 18777111-4 2008 Focal application of heated solutions demonstrated that the normal threshold (approximately 42 degrees C) of TRPV1 activation was reduced in the presence of capsaicin (1 microM) to approximately 30 degrees C. In current-clamp recordings, increasing the temperature of the solution resulted in larger membrane depolarizations and significantly altered the pattern and onset of the action potential train evoked by 1 microM capsaicin. Capsaicin 422-431 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 109-114 18515644-5 2008 ABT-102 also potently (IC(50) = 1-16 nM) inhibits capsaicin-evoked currents in rat dorsal root ganglion (DRG) neurons and currents evoked through activation of recombinant rat TRPV1 currents by capsaicin, protons, or heat. Capsaicin 194-203 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 176-181 18034335-2 2008 As a result, we found that capsaicin can induce SP release in the absence of extracellular Ca2+ by activating transient receptor potential vanilloid receptor subtype 1 (TRPV1). Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 169-174 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. Capsaicin 217-226 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. Capsaicin 217-226 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18405883-7 2008 RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin. Capsaicin 217-226 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 123-128 18405883-8 2008 Acute stress suppressed LTP and enabled LTD, but the TRPV1 agonist capsaicin effectively prevented this effect. Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-58 18582539-5 2008 This long-term up-regulation of TRPV1 expression by TNFalpha correlated with enhancement in capsaicin-induced calcitonin gene-related peptide release (P<0.05). Capsaicin 92-101 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 18798491-12 2008 CONCLUSION: Pretreatment with capsaicin can attenuate myocardial ischemia-reperfusion injury, of which the likely mechanism is by stimulating capsaicin receptor or TRPV1 and further activating substance P receptor in the rat in vivo. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 142-160 18798491-12 2008 CONCLUSION: Pretreatment with capsaicin can attenuate myocardial ischemia-reperfusion injury, of which the likely mechanism is by stimulating capsaicin receptor or TRPV1 and further activating substance P receptor in the rat in vivo. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 164-169 18561998-8 2008 Additionally, the enhanced NO synthesis caused by capsaicin was abrogated by co-treatment with capsazepine, illustrating that NOS activity could be modulated by TRPV1. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 161-166 18508045-9 2008 These results suggest that SA13353 inhibits TNF-alpha production through activation of capsaicin-sensitive afferent neurons mediated via TRPV1 in vivo. Capsaicin 87-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 137-142 17933570-3 2008 Increased excitability of capsaicin sensitive primary afferents (CSPAs), which express TRPV1 receptors, also contributes to central sensitization. Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-92 18598261-1 2008 Patch-clamp techniques and Ca2+ imaging were used to examine the interaction between neurokinins (NK) and the capsaicin(CAPS)-evoked transient receptor potential vanilloid receptor 1 (TRPV1) responses in rat dorsal root ganglia neurons. Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 133-182 18598261-1 2008 Patch-clamp techniques and Ca2+ imaging were used to examine the interaction between neurokinins (NK) and the capsaicin(CAPS)-evoked transient receptor potential vanilloid receptor 1 (TRPV1) responses in rat dorsal root ganglia neurons. Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 184-189 18034335-4 2008 In the presence of extracellular Ca2+, a capsaicin-induced maximal release of SP obtained at 100 nM capsaicin was attenuated by either the phosphoinositide 3-kinase (PI3K) inhibitors (wortmannin and LY294002), the inositol 1,4,5-triphosphate (IP3)-induced Ca2+ release blocker (2-aminoethyl diphenylborinate, 2-APB) or a specific antagonist of TRPV1 (capsazepine). Capsaicin 41-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 344-349 18034335-6 2008 In summary, the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms, one requiring extracellular Ca2+, the activation of PI3K and the IP3-dependent intracellular Ca2+ release, and the other which is independent of extracellular Ca2+ but involves the activation of MEK. Capsaicin 39-48 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 30-35 18480286-8 2008 These data suggest that mitochondria control vanilloid-induced neurotransmission by translating the strength of presynaptic TRPV1 stimulation into duration of the postsynaptic response. Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-129 18331834-2 2008 It was found in this work that a TRPV1 agonist capsaicin, and acidic solution (pH 5.5) induced increases in cytosolic calcium concentration ([Ca(2+)](c)) and reactive oxygen species (ROS) production in synoviocytes isolated from a rat model of collagen-induced arthritis. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-38 18398380-1 2008 Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown. Capsaicin 136-145 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-94 18460982-0 2008 Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats. Capsaicin 36-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 18460982-1 2008 We evaluated the effect of capsaicin, one of the transient receptor potential vanilloid receptor 1 (TRPV1) agonists, on ischemic acute renal failure (ARF) in rats. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-98 18460982-1 2008 We evaluated the effect of capsaicin, one of the transient receptor potential vanilloid receptor 1 (TRPV1) agonists, on ischemic acute renal failure (ARF) in rats. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 100-105 18461159-10 2008 The TRPV1 activation requires residues in transmembrane segments two through four of the voltage-sensor domain, a region previously implicated in capsaicin activation of TRPV1 and analogous menthol activation of TRPM8. Capsaicin 146-155 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 18461159-10 2008 The TRPV1 activation requires residues in transmembrane segments two through four of the voltage-sensor domain, a region previously implicated in capsaicin activation of TRPV1 and analogous menthol activation of TRPM8. Capsaicin 146-155 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 170-175 18398380-1 2008 Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown. Capsaicin 136-145 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 18398380-1 2008 Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown. Capsaicin 147-150 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-94 18398380-1 2008 Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown. Capsaicin 147-150 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 18256211-3 2008 We found that TRPV1 stimulation by capsaicin (intra-arterial administration) of the isolated, perfused right hind limb of the rat increased vascular resistance (by 98 +/- 21 mm Hg at 10 mug) in association with decreased skeletal muscle perfusion and elevation of skin perfusion (detected by dual-channel laser Doppler flowmetry). Capsaicin 35-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 18391945-1 2008 Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious heat, capsaicin and other diverse stimuli. Capsaicin 98-107 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-40 18391945-1 2008 Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious heat, capsaicin and other diverse stimuli. Capsaicin 98-107 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 18307678-5 2008 Capsaicin ameliorates urinary bladder symptoms through its stimulatory action on the transient receptor potential vanilloid 1 (TRPV1) calcium channel, resulting in desensitization of bladder sensory nerve terminals. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 85-125 18178674-4 2008 In the whole cell perforated patch-clamp study, when the temperature was increased from normal (approximately 36 degrees C) to hyperthermic (approximately 40.6 degrees C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1-3 receptors, were both significantly increased. Capsaicin 236-245 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 276-321 18178674-4 2008 In the whole cell perforated patch-clamp study, when the temperature was increased from normal (approximately 36 degrees C) to hyperthermic (approximately 40.6 degrees C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1-3 receptors, were both significantly increased. Capsaicin 236-245 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 323-328 18178674-4 2008 In the whole cell perforated patch-clamp study, when the temperature was increased from normal (approximately 36 degrees C) to hyperthermic (approximately 40.6 degrees C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1-3 receptors, were both significantly increased. Capsaicin 236-245 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 401-406 18222611-3 2008 NMDA alone or when co-administered with D-serine failed to induce NK1r internalization, whereas activation of spinal TRPV1 receptors by capsaicin resulted in a notable NK1r internalization. Capsaicin 136-145 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 117-122 18307678-5 2008 Capsaicin ameliorates urinary bladder symptoms through its stimulatory action on the transient receptor potential vanilloid 1 (TRPV1) calcium channel, resulting in desensitization of bladder sensory nerve terminals. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 127-132 18178321-0 2008 Mechanisms of potassium- and capsaicin-induced axonal calcitonin gene-related peptide release: involvement of L- and T-type calcium channels and TRPV1 but not sodium channels. Capsaicin 29-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 145-150 18296611-2 2008 We hypothesized that certain PGE(2) receptor subtypes (EP1-EP4) are co-expressed with TRPV(1) in trigeminal nociceptors and sensitize responses to a TRPV(1) agonist, capsaicin. Capsaicin 166-175 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 86-93 18329285-2 2008 Capsaicin (Cap), a selective TRPV1 agonist, was perfused in the presence or absence of capsazepine (Capz), a selective TRPV1 antagonist, CGRP(8-37), a selective calcitonin gene-related peptide (CGRP) receptor antagonist, or spantide II (Spa), a selective substance P (SP) receptor antagonist. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-34 18178321-10 2008 These results suggest that slow depolarization by high extracellular potassium activates axonal low threshold (T-type) as well as high threshold-activated (L-type) voltage-gated calcium channels to mediate iCGRP release, and that capsaicin-induced release is largely dependent on calcium influx through TRPV1. Capsaicin 230-239 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 303-308 17693108-5 2008 Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation. Capsaicin 18-27 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 222-242 18032552-6 2008 Intrapelvic administration of capsaicin or a specific TRPV1 agonist, resiniferatoxin, resulted in a dose-dependent increase in multi-unit ARNA and SP release, and these effects were blocked by the TRVP1 blocker capsazepine. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 17984664-5 2007 Capsaicin, a selective TRPV1 receptor agonist, or CGRP dose-dependently decreased MAP in normal or high-sodium-treated rats, with a greater effect in the latter. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 23-28 17950047-0 2008 Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1. Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 113-118 18077685-4 2007 Intra-VL-PAG injection of capsaicin increased the threshold of thermal pain sensitivity, whereas the selective TRPV1 antagonist 5"-iodo-resiniferatoxin (I-RTX) facilitated nociceptive responses, and blocked capsaicin analgesic effect at a dose inactive per se. Capsaicin 207-216 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-116 18159132-6 2007 Collectively, the mechanism accounting for the capsaicin-induced increase in the intestinal cefazolin absorption is probably that capsaicin associating with TRPV1 increases the intrinsic permeability of cefazolin in intestine. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 157-162 18159132-6 2007 Collectively, the mechanism accounting for the capsaicin-induced increase in the intestinal cefazolin absorption is probably that capsaicin associating with TRPV1 increases the intrinsic permeability of cefazolin in intestine. Capsaicin 130-139 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 157-162 17920775-2 2007 In the rat, activation of capsaicin-sensitive nociceptors, which express the transient receptor potential vanilloid type 1 (TRPV1) receptor, induces meningeal vasodilatation, a significant component of neurogenic inflammation, through the release of calcitonin gene-related peptide (CGRP). Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-122 17920775-2 2007 In the rat, activation of capsaicin-sensitive nociceptors, which express the transient receptor potential vanilloid type 1 (TRPV1) receptor, induces meningeal vasodilatation, a significant component of neurogenic inflammation, through the release of calcitonin gene-related peptide (CGRP). Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-129 17920775-10 2007 In conclusion, this study revealed a marked impairment of meningeal TRPV1-IR nerves in streptozotocin diabetic rats by showing reduced neurogenic sensory vasodilatation, decreased capsaicin-evoked CGRP release and reduction in the number of TRPV1-IR nerve fibers of the dura mater. Capsaicin 180-189 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 17346695-12 2007 Whereas, TRPV1 agonists, capsaicin and piperine, inhibited gastric lesions induced by ethanol, 1% ammonia, and aspirin, but had less of an effect on 0.6 M HCl-induced gastric lesions. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-14 17961222-0 2007 Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin. Capsaicin 137-146 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-14 17961222-1 2007 BACKGROUND: Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Capsaicin 173-182 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-119 17961222-1 2007 BACKGROUND: Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs). Capsaicin 173-182 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 121-126 17961222-4 2007 RESULTS: Here we used pharmacological manipulations to analyze the roles of TRPV1 and neuropeptidergic receptors in the DRR-mediated neurogenic inflammation induced by intradermal injection of capsaicin. Capsaicin 193-202 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 76-81 17961222-9 2007 Dose-response analysis of the antagonistic effect of the TRPV1 receptor antagonist, capsazepine administered peripherally, shows that the capsaicin-evoked inflammation was inhibited in a dose-dependent manner, and nearly completely abolished by capsazepine at doses between 30-150 mug. Capsaicin 138-147 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 17961222-12 2007 CONCLUSION: Our data suggest that 1) the generation of DRRs is critical for driving the release of neuropeptides antidromically from primary afferent nociceptors; 2) activation of TRPV1 receptors in primary afferent nociceptors following intradermal capsaicin injection initiates this process; 3) the released CGRP and SP participate in neurogenic inflammation. Capsaicin 250-259 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 180-185 17629487-2 2007 alpha-Methyl substituted analogues showed potent and stereospecific antagonism to the action of capsaicin on rat TRPV1 heterologously expressed in Chinese hamster ovary cells. Capsaicin 96-105 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 113-118 17586490-11 2007 These results indicate that capsaicin produces muscle contractions by stimulating the TRPV1 receptor, followed by release of neuropeptides that can activate tachykinin NK(1) and/or NK(2) receptors in the bladder and that the contractile response to anandamide is mediated at least in part by activation of prostanoid EP(1) receptors due to production of prostaglandins in addition to TRPV1 receptor activation. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 86-91 17586490-11 2007 These results indicate that capsaicin produces muscle contractions by stimulating the TRPV1 receptor, followed by release of neuropeptides that can activate tachykinin NK(1) and/or NK(2) receptors in the bladder and that the contractile response to anandamide is mediated at least in part by activation of prostanoid EP(1) receptors due to production of prostaglandins in addition to TRPV1 receptor activation. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 384-389 17683869-11 2007 TRPA1 agonist allyl isothiocyanate (mustard oil) 50-100 microM and TRPV1 agonist capsaicin 1-3 microM had no effect. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 67-72 17596195-1 2007 Heat-activated ion channels from the vanilloid-type TRP group (TRPV1-4) seem to be central for heat-sensitivity of nociceptive sensory neurons. Capsaicin 37-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-70 17339608-5 2007 Moreover, the vanilloid capsaicin, a full agonist of transient receptor potential channel VR1, did not affect [Ca(2+)](i)levels in the RBL-2H3 cells, thus excluding the involvement of this receptor in the CBD-mediated effects. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-93 17363391-6 2007 Capsaicin potently increased the frequency but not the amplitude of mEPSCs in a calcium-dependent manner, suggesting TRPV1-mediated glutamate release from presynaptic terminals of sensory neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 117-122 17914397-5 2007 QX-314 applied externally had no effect on the activity of sodium channels in small sensory neurons when applied alone, but when applied in the presence of the TRPV1 agonist capsaicin, QX-314 blocked sodium channels and inhibited excitability. Capsaicin 174-183 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 160-165 17914397-6 2007 Inhibition by co-applied QX-314 and capsaicin was restricted to neurons expressing TRPV1. Capsaicin 36-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 17652633-1 2007 Capsaicin, the active ingredient in some pain-relieving creams, is an agonist of a nonselective cation channel known as the transient receptor potential vanilloid type 1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-169 17652633-1 2007 Capsaicin, the active ingredient in some pain-relieving creams, is an agonist of a nonselective cation channel known as the transient receptor potential vanilloid type 1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 171-176 17652633-2 2007 The pain-relieving mechanism of capsaicin includes desensitization of the channel, suggesting that TRPV1 antagonism may be a viable pain therapy approach. Capsaicin 32-41 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 17652633-5 2007 Both AMG 517 and AMG8163 potently and completely antagonized capsaicin, proton, and heat activation of TRPV1 in vitro and blocked capsaicin-induced flinch in rats in vivo. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-108 17586490-1 2007 The contractile responses to capsaicin and anandamide, exogenous and endogenous agonists for transient receptor potential vanilloid receptor 1 (TRPV1), respectively, were investigated in muscle strips isolated from the rat urinary bladder. Capsaicin 29-38 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 144-149 17586490-7 2007 The response to capsaicin was abolished in the presence of a TRPV1 antagonist, N-(4-tertiarybutylphenyl)-4-(3-chlorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), but not altered in the presence of either tetrodotoxin, atropine or indomethacin. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 17666428-3 2007 Ca(2+)-dependent CGRP release was evoked with K(+)-depolarisation and, to lower levels, by capsaicin or bradykinin from neurons that contain the vanilloid receptor 1 and/or bradykinin receptor 2. Capsaicin 91-100 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 145-165 17632091-2 2007 Similar with cultured rat trigeminal ganglion (TG) neurons, the amplitude of tetrodotoxin-resistant (TTX-R) sodium current was reduced 85% by 1 muM capsaicin in capsaicin sensitive neurons, while only 6% was blocked in capsaicin insensitive neurons of TRPV1(+/+) mice. Capsaicin 148-157 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 252-257 17581853-14 2007 These effects of anandamide differ from those of the classical exogenous TRPV1-agonist capsaicin and suggest a primarily modulatory mode of action of anandamide. Capsaicin 87-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 73-78 17585749-8 2007 In addition, compound 74 was shown to be efficacious at blocking a TRPV1-mediated physiological response in vivo in the capsaicin-induced hypothermia model in rats; however, it was ineffective at preventing thermal hyperalgesia induced by complete Freund"s adjuvant in rats. Capsaicin 120-129 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 67-72 17579717-2 2007 Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit Ca(2+)-uptake via the vanilloid inducible Ca(2+)-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca(2+) entry. Capsaicin 112-121 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 176-181 17579717-3 2007 Functional assays on TRPV1 expressing cells support direct, dose-dependent inhibition of vanilloid-induced (45)Ca(2+)-uptake at microM concentrations: calmidazolium (broad range) > or = trifluoperazine (narrow range) chlorpromazine/amitriptyline>fluphenazine>>W-7 and W-13 (only partially). Capsaicin 89-98 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 17579717-5 2007 Camstatin, a selective peptide blocker of calmodulin, inhibits vanilloid-induced Ca(2+)-uptake in intact TRPV1(+) cells, and suggests an extracellular site of inhibition. Capsaicin 63-72 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 105-110 17379752-7 2007 When pH levels in the infused solution were 7.4, 6.5, 5.5, and 4.5, capsaicin (1 microg/kg), a TRPV1 agonist, was injected into the artery. Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 95-100 17565537-7 2007 Furthermore, they express capsaicin receptor transient receptor potential vanilloid family-1 (TRPV-1) and respond to capsaicin with increases in intracellular calcium. Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 94-100 17456676-1 2007 BACKGROUND: The vanilloid receptors (TRPV1) are found in peripheral nerve fibers; their stimulation by capsaicin leads to release of calcitonin gene-related peptide and other neuropeptides participating in neuroinflammation. Capsaicin 103-112 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-42 17485923-1 2007 Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, was suggested to mediate the inhibitory effect of capsaicin on the vagally mediated striated muscle contractions in the rat esophagus. Capsaicin 106-115 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-71 17485923-1 2007 Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, was suggested to mediate the inhibitory effect of capsaicin on the vagally mediated striated muscle contractions in the rat esophagus. Capsaicin 242-251 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-71 17392452-1 2007 The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons (pH <5.7), and heat. Capsaicin 162-171 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 23-28 17392452-1 2007 The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons (pH <5.7), and heat. Capsaicin 162-171 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 30-70 17353553-4 2007 Here we explore how changes in tonicity affect TRPV1 receptor-mediated responses to capsaicin in dissociated rat trigeminal ganglion (TG) neurons. Capsaicin 84-93 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 47-52 17239544-2 2007 In this study, we determined if removal of TRPV1-expressing afferent neurons by resiniferatoxin (RTX), an ultrapotent capsaicin analog, influences the development of opioid analgesic tolerance. Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-48 17156774-1 2007 Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory effect of capsaicin on vagally mediated striated muscle contractions in the rat esophagus. Capsaicin 106-115 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-71 17156774-1 2007 Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory effect of capsaicin on vagally mediated striated muscle contractions in the rat esophagus. Capsaicin 247-256 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-71 17151223-11 2007 Most menthol-responsive units also responded to the TRPA1 agonists cinnamaldehyde and mustard oil, and the TRPV1 agonist capsaicin. Capsaicin 121-130 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 107-112 16365187-4 2006 In contrast, capsaicin (10 or 30 microg/kg), a selective TRPV1 agonist, dose-dependently decreased mean arterial pressure in all of the groups with the most profound magnitude in DR+HS rats compared with the other 3 groups. Capsaicin 13-22 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 57-62 21204495-0 2007 Complex Regulation of TRPV1 by Vanilloids A subset of sensory neurons is characterized by a unique sensitivity to capsaicin, the piquant ingredient in hot chili peppers [1]. Capsaicin 114-123 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 21204495-3 2007 Capsaicin evokes these responses by interacting at a specific membrane recognition site, originally termed the vanilloid receptor [1]. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-133 16797124-2 2006 The aim of this study was to evaluate the role of transient receptor potential vanilloid 1 receptor (TRPV1) containing nociceptors in this process, by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model. Capsaicin 233-242 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-99 16797124-2 2006 The aim of this study was to evaluate the role of transient receptor potential vanilloid 1 receptor (TRPV1) containing nociceptors in this process, by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model. Capsaicin 233-242 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-106 16887920-7 2006 Intrapericardial capsazepine (1 mg/ml, 0.2 ml, 3 min), a specific antagonist of TRPV1, sharply attenuated excitatory responses to CAP in 5/5 neurons, but responses to BK in 5/5 neurons was maintained. Capsaicin 130-133 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 80-85 17229097-9 2006 These data suggest that transport of both NADA and capsaicin into DRG neurons and the subsequent activation of TRPV1 is partly governed by FAAH-dependent mechanisms as well as via the putative AEA membrane transporter. Capsaicin 51-60 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-116 17187013-13 2006 The promotion of VR1 mRNA and VR1 protein expression by butyrate implicated that VR1 may be involved in the mechanisms of sensory neuropeptide release evoked by capsaicin. Capsaicin 161-170 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 17-20 17187013-13 2006 The promotion of VR1 mRNA and VR1 protein expression by butyrate implicated that VR1 may be involved in the mechanisms of sensory neuropeptide release evoked by capsaicin. Capsaicin 161-170 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 30-33 17187013-13 2006 The promotion of VR1 mRNA and VR1 protein expression by butyrate implicated that VR1 may be involved in the mechanisms of sensory neuropeptide release evoked by capsaicin. Capsaicin 161-170 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 30-33 16950406-0 2006 Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1. Capsaicin 17-30 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-101 16950406-1 2006 Analogs of capsaicin, such as capsaicinoids and capsinoids, activate a cation channel, transient receptor potential cation channel vanilloid subfamily 1 (TRPV1), and then increase the intracellular calcium concentration ([Ca2+]i). Capsaicin 11-20 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 154-159 16950406-1 2006 Analogs of capsaicin, such as capsaicinoids and capsinoids, activate a cation channel, transient receptor potential cation channel vanilloid subfamily 1 (TRPV1), and then increase the intracellular calcium concentration ([Ca2+]i). Capsaicin 30-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 154-159 16957598-4 2006 Conversely, the TRPV1 agonist capsaicin caused an increase in miniature excitatory postsynaptic currents in neurons in the superficial but not deep laminae. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 16-21 16982866-8 2006 In vivo, we also found that intranigral injection of CAP or 12-hydroperoxyeicosatetraenoic acid, an endogenous agonist of TRPV1, into the rat brain produced microglial damage via TRPV1 in the substantia nigra, as visualized by immunocytochemistry. Capsaicin 53-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 16982866-8 2006 In vivo, we also found that intranigral injection of CAP or 12-hydroperoxyeicosatetraenoic acid, an endogenous agonist of TRPV1, into the rat brain produced microglial damage via TRPV1 in the substantia nigra, as visualized by immunocytochemistry. Capsaicin 53-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 179-184 16988918-1 2006 The vanilloid receptor (VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid and high temperature. Capsaicin 93-102 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-27 16988918-2 2006 VR1 protein functions both as a receptor for capsaicin and a transducer of noxious thermal stimuli. Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-3 16988918-4 2006 VR1 is also expressed in a capsaicin-sensitive and peptide-containing sub-population of primary sensory nerves. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-3 16800863-3 2006 We found that MCD significantly reduced TRPV1-mediated capsaicin- and proton-activated currents. Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 40-45 16725114-2 2006 Here we show that vanilloid receptor (TRPV1) stimulation with capsaicin and activation of TRPA1 with allyl isothiocyanate or cinnamaldehyde cause a graded contraction of the rat urinary bladder in vitro. Capsaicin 62-71 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 38-43 16725114-6 2006 The selective TRPV1 receptor antagonist SB 366791 (10 microM) blocks capsaicin-induced contraction, but partially reduces allyl isothiocyanate- or cinnamaldehyde-mediated contraction. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 16595689-5 2006 Capsaicin (a TRPV1 agonist), menthol (a TRPM8 agonist), and icilin (a TRPM8 and TRPA1 agonist) increased intracellular calcium and evoked cationic currents in subsets of neurons, as did the appropriate temperature changes (>43 degrees , <25 degrees , and <17 degrees C, respectively). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 13-18 16718783-9 2006 Capsaicin evoked an increase in [Ca2+]i in rat TRPV1-transfected HEK293 cells while lafutidine did not. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 47-52 16718783-10 2006 CONCLUSION: These results suggest that although both lafutidine and capsaicin exhibit gastro-protective action mediated by CSN, the mode of their effects differs regarding the dependency on endogenous PGs/IP receptors and TRPV1. Capsaicin 68-77 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 222-227 16399878-5 2006 Injection of the TRPV1 agonist capsaicin into the pancreatic duct induced endocytosis of the neurokinin 1 receptor in spinal neurons in the dorsal horn (T10), indicative of SP release upon stimulation of pancreatic sensory nerves. Capsaicin 31-40 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 17-22 16196077-12 2006 CONCLUSIONS: These studies suggest that long-term diabetes causes vascular dysfunction in epineurial arterioles of the sciatic nerve that includes a decrease in capsaicin-induced vasoconstriction that is likely due to a decrease in the expression of vanilloid receptor 1. Capsaicin 161-170 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 250-270 16717036-2 2006 Moreover, based on the highly selective agonism of trans-capsaicin for TRPV1 receptors, drug products containing high concentrations of trans-capsaicin are under development as analgesics. Capsaicin 51-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-76 16717036-2 2006 Moreover, based on the highly selective agonism of trans-capsaicin for TRPV1 receptors, drug products containing high concentrations of trans-capsaicin are under development as analgesics. Capsaicin 136-151 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 71-76 16797124-9 2006 Our results show an important role of TRPV1-containing nociceptors in the development of post-surgical hypersensitivity and suggest that local, high-concentration capsaicin treatment could be used to reduce it. Capsaicin 163-172 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 38-43 16982866-3 2006 Furthermore, exposure of these cells to TRPV1 agonists, capsaicin (CAP) and resiniferatoxin (RTX), triggered cell death. Capsaicin 56-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 40-45 16982866-3 2006 Furthermore, exposure of these cells to TRPV1 agonists, capsaicin (CAP) and resiniferatoxin (RTX), triggered cell death. Capsaicin 67-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 40-45 16988037-8 2006 Capsaicin also increased the frequency of glutamatergic postsynaptic currents in a VR1-mediated manner. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-86 16831854-3 2006 Capsaicin-, menthol-, and mustard oil-sensitive receptors are TRPV1, TRPM8, and TRPA1, respectively. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-67 16806299-5 2006 In normal rats, the TRPV1 agonist capsaicin (1 mg/kg) or the FAAH inhibitor URB597 (10 mg/kg) caused a significant reduction in movement in both the horizontal (locomotion) and vertical (rearing) planes (-45% and -53% respectively with capsaicin; -33% and -37% for URB597). Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 20-25 16806299-5 2006 In normal rats, the TRPV1 agonist capsaicin (1 mg/kg) or the FAAH inhibitor URB597 (10 mg/kg) caused a significant reduction in movement in both the horizontal (locomotion) and vertical (rearing) planes (-45% and -53% respectively with capsaicin; -33% and -37% for URB597). Capsaicin 236-245 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 20-25 16806299-6 2006 Capsaicin-induced hypolocomotion was attenuated by the TRPV1 antagonist, capsazepine. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 16926503-4 2006 The effectiveness of (+/-)-capsaicinol in TRPV1 activation (EC(50)=1.1 microM) was found to be weaker than that of capsaicin (EC(50)=0.017 microM), whereas the efficacy of (+/-)-capsaicinol reached 75% of that of capsaicin. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 42-47 16926503-7 2006 The relative pungency of capsaicinol to capsaicin was coincident with the relative effectiveness in inducing these TRPV1-related actions. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 115-120 16627682-7 2006 We concluded that 1) the initial bradypneic response to H2O2 results from activation of both TRPV1 and P2X receptors, possibly located at terminals of vagal lung capsaicin-sensitive afferent fibers; 2) the functioning of the TRPV1 and P2X receptors in triggering the initial bradypnea is, in part, mediated through the actions of cyclooxygenase metabolites and ATP, respectively; and 3) these mechanisms do not contribute to the H2O2-evoked delayed tachypnea. Capsaicin 162-171 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-98 16459279-3 2006 Local injections of capsaicin (0.1-30 microg) into the hindpaw produced flinching and biting/licking behaviors over 5 min, and these were reduced by capsazepine, a competitive antagonist for capsaicin at the TRPV1 receptor. Capsaicin 20-29 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-213 16503963-1 2006 In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-132 16503963-1 2006 In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 134-139 16503963-1 2006 In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods. Capsaicin 39-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-132 16503963-1 2006 In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods. Capsaicin 39-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 134-139 16207832-9 2006 In rTRPV1-expressing CHO cells, they caused a significant rightward shift in the log concentration-response curve for the TRPV1 receptor agonist capsaicin (3-methoxy-4-hydroxy)benzyl-8-methyl-6-nonenamide). Capsaicin 145-154 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 3-9 16459279-3 2006 Local injections of capsaicin (0.1-30 microg) into the hindpaw produced flinching and biting/licking behaviors over 5 min, and these were reduced by capsazepine, a competitive antagonist for capsaicin at the TRPV1 receptor. Capsaicin 191-200 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-213 16373680-3 2006 Immunohistochemical analyses of human and rat trigeminal neurons demonstrated that a capsaicin-sensitive subclass of nociceptors (defined by expression of TRPV1, a capsaicin receptor) expresses both TLR4 and CD14. Capsaicin 85-94 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 155-160 16091583-1 2006 The capsaicin receptor and transient receptor potential channel TRPV1 senses heat, protons, and vanilloid agonists in peripheral sensory ganglia. Capsaicin 96-105 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 64-69 16373680-3 2006 Immunohistochemical analyses of human and rat trigeminal neurons demonstrated that a capsaicin-sensitive subclass of nociceptors (defined by expression of TRPV1, a capsaicin receptor) expresses both TLR4 and CD14. Capsaicin 85-94 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 164-182 15947039-5 2005 In response to I-RTX in vitro, HEK293 cells expressing rat TRPV1 exhibited increases in intracellular Ca(2+) (biphasic, EC(50) = 56.7 nM and 9.9 microM) that depended on Ca(2+) influx and outwardly rectifying, capsazepine-sensitive currents that were smaller than those evoked by 1 microM capsaicin. Capsaicin 289-298 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-64 16788306-10 2006 The expression of TRPV1 mRNA, a specific marker of capsaicin-sensitive small sensory neurons, was investigated by RT-PCR 4 days after the capsaicin treatment. Capsaicin 51-60 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-23 16788306-10 2006 The expression of TRPV1 mRNA, a specific marker of capsaicin-sensitive small sensory neurons, was investigated by RT-PCR 4 days after the capsaicin treatment. Capsaicin 138-147 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-23 16095822-2 2005 Moreover, CaMKIIalpha phosphorylates the vanilloid receptor type 1 (TRPV1), thereby regulating vanilloid agonist binding to the receptor. Capsaicin 41-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 16477145-7 2005 In the patch-clamp experiments, we observed capsaicin-induced inward currents that were inhibited by capsazepine, a TRPV1 channel antagonist. Capsaicin 44-53 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 16135784-1 2005 Vanilloid receptor 1 (TRPV1) is activated by chemical ligands (e.g., capsaicin and protons) and heat. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-20 16135784-1 2005 Vanilloid receptor 1 (TRPV1) is activated by chemical ligands (e.g., capsaicin and protons) and heat. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 15998524-5 2005 In vitro, BCTC inhibited capsaicin (300 nM)-induced releases of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-like immunoreactivity (SP-LI) from the rat spinal cord slice preparations with IC(50)s of 37.0 and 36.0 nM, respectively, confirming that BCTC potently inhibits TRPV1 function in the rat spinal cord. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 305-310 15882882-11 2005 These results indicate that capsaicin activates a TRPV1-independent non-SOCE pathway in neutrophils. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-55 16056236-6 2005 The TRPV1 antagonist capsazepine (1 mM) reduced the response to capsaicin (100 microM), from 1.78+/-0.15 to 0.63+/-0.10 (n = 4). Capsaicin 64-73 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 16056236-7 2005 The NK1 receptor antagonists GR205171 (100 microM) and SDZ NKT 376 (1 mM) also reduced the response to capsaicin (from 1.75+/-0.14 to 0.46+/-0.08; n = 6, and from 1.85+/-0.13 to 0.48+/-0.05; n = 5, respectively), indicating that capsaicin acts via TRPV1 in series with NK(1). Capsaicin 103-112 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 248-253 16087784-1 2005 To test the hypothesis that activation of the vanilloid receptor 1 (VR1) expressed in sensory nerves innervating the renal pelvis leads to diuresis and natriuresis, a selective VR1 receptor agonist, capsaicin (2.4 nmol), or vehicle was perfused intravenously or into the left renal pelvis of anesthetized rats at a rate without changing renal perfusion pressure. Capsaicin 199-208 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 46-66 16087784-1 2005 To test the hypothesis that activation of the vanilloid receptor 1 (VR1) expressed in sensory nerves innervating the renal pelvis leads to diuresis and natriuresis, a selective VR1 receptor agonist, capsaicin (2.4 nmol), or vehicle was perfused intravenously or into the left renal pelvis of anesthetized rats at a rate without changing renal perfusion pressure. Capsaicin 199-208 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-71 16087784-3 2005 Capsaicin perfusion into the left renal pelvis but not intravenously caused significant increases in urine flow rate and urinary sodium excretion bilaterally in a dose-dependent manner, which were abolished by capsazepine, a selective VR1 receptor antagonist, given ipsilaterally to the renal pelvis or by ipsilateral renal denervation. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 235-238 16144988-5 2005 Likewise, administration of capsaicin, a selective VR1 receptor agonist, dose-dependently decreased MAP in both HS- and NS-treated rats. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-54 15985616-10 2005 These results suggested that both capsaicin and acid increase gastric HCO3(-) secretion via a common pathway, involving PG and NO as well as capsaicin-sensitive afferent neurons, yet their responses differ concerning TRPV1 or prostanoid receptor dependence. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 217-222 16191202-0 2005 Acidification of rat TRPV1 alters the kinetics of capsaicin responses. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 21-26 16191202-1 2005 TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C. These activators can enhance the potency of one another, shifting the activation curve for TRPV1 to the left. Capsaicin 85-94 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 15994849-12 2005 ), a selective VR1 antagonist, inhibited the capsaicin-evoked response, but not that of propofol. Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 15-18 16305749-8 2005 Remarkably few (9%) ASIC3+ cells express P2X3 receptors (an ATP-gated ion channel), whereas 31% express TRPV1 (the noxious heat and capsaicin-activated ion channel also known as VR1). Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 178-181 16269136-1 2005 It is discussed whether capsaicin, an agonist of the pain mediating TRPV1 receptor, decreases or increases voltage-activated calcium channel (VACC) currents (I(Ca(V))). Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-73 16269136-10 2005 These effects of capsaicin on different VACCs in small DRG neurones, which most likely express the TRPV1 receptor, may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1. Capsaicin 17-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 16269136-10 2005 These effects of capsaicin on different VACCs in small DRG neurones, which most likely express the TRPV1 receptor, may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1. Capsaicin 17-26 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 218-223 16269136-10 2005 These effects of capsaicin on different VACCs in small DRG neurones, which most likely express the TRPV1 receptor, may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1. Capsaicin 182-191 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 16100528-2 2005 Previously, selective mutagenesis experiments identified an intracellular residue (S512Y) critical to discriminating between pH and vanilloid (capsaicin) gating of the rat TRPV1 receptor. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 172-177 16100528-2 2005 Previously, selective mutagenesis experiments identified an intracellular residue (S512Y) critical to discriminating between pH and vanilloid (capsaicin) gating of the rat TRPV1 receptor. Capsaicin 143-152 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 172-177 16100528-3 2005 2 In this study, switching the equivalent residue in the human TRPV1 (which has some significant differences with the rat TRPV1) also rendered this channel relatively insensitive to activation by capsaicin and proved critical in determining the receptor"s sensitivity to the putative endovanilloid N-arachidonoyl-dopamine (NADA), suggesting a similar mode of activation for these two agonists. Capsaicin 196-205 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 122-127 16081483-3 2005 The NO release elicited by either anandamide or capsaicin was reduced by the TRPV1 receptor antagonists 5"-iodoresiniferatoxin, SB 366791 and capsazepine as well as by the cannabinoid CB(1) receptor antagonists SR 141716A or AM251. Capsaicin 48-57 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-82 16191202-1 2005 TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C. These activators can enhance the potency of one another, shifting the activation curve for TRPV1 to the left. Capsaicin 85-94 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 7-27 16191202-1 2005 TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C. These activators can enhance the potency of one another, shifting the activation curve for TRPV1 to the left. Capsaicin 85-94 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 256-261 16191202-2 2005 In this study, for example, we observed an approximately 10-fold shift in the capsaicin EC50 (640 nM to 45 nM) for rat TRPV1 receptors expressed in HEK-293 cells when the pH was lowered from 7.4 to 5.5. Capsaicin 78-87 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 119-124 16191202-7 2005 When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 5-10 16191202-7 2005 When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 139-144 16191202-7 2005 When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold. Capsaicin 112-121 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 5-10 16191202-7 2005 When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold. Capsaicin 112-121 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 139-144 16192383-3 2005 Capsaicin and menthol, two other topically applied agents widely used for similar purposes, are known to excite and desensitize sensory nerves by acting on two members of transient receptor potential (TRP) channel superfamily: heat-sensitive TRP vanilloid subtype 1 (TRPV1) and cold-sensitive TRP channel M8, respectively. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 242-265 16192383-3 2005 Capsaicin and menthol, two other topically applied agents widely used for similar purposes, are known to excite and desensitize sensory nerves by acting on two members of transient receptor potential (TRP) channel superfamily: heat-sensitive TRP vanilloid subtype 1 (TRPV1) and cold-sensitive TRP channel M8, respectively. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 267-272 16192383-7 2005 Camphor activation of rat TRPV1 was mediated by distinct channel regions from capsaicin, as indicated by camphor activation in the presence of the competitive inhibitor capsazepine and in a capsaicin-insensitive point mutant. Capsaicin 78-87 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 16192383-7 2005 Camphor activation of rat TRPV1 was mediated by distinct channel regions from capsaicin, as indicated by camphor activation in the presence of the competitive inhibitor capsazepine and in a capsaicin-insensitive point mutant. Capsaicin 190-199 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-31 16192383-9 2005 TRPV1 desensitization is believed to contribute to the analgesic actions of capsaicin. Capsaicin 76-85 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 15950380-2 2005 The present paper characterizes the effects of SB366791, a novel TRPV1 antagonist, on capsaicin-evoked responses both in vitro and in vivo using rat models. Capsaicin 86-95 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 65-70 15907794-11 2005 We found that this leakage was enhanced by capsaicin and was antagonized by capsazepine, a capsaicin blocker, indicating that leakage of Ca2+ occurs through a channel composed of VR1. Capsaicin 43-52 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 179-182 15907794-11 2005 We found that this leakage was enhanced by capsaicin and was antagonized by capsazepine, a capsaicin blocker, indicating that leakage of Ca2+ occurs through a channel composed of VR1. Capsaicin 91-100 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 179-182 15978575-2 2005 The present paper characterizes the effects of JYL1421 (SC0030), a TRPV1 receptor antagonist, on capsaicin-evoked responses both in vitro and in vivo in the rat. Capsaicin 97-106 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 67-72 15782105-7 2005 RESULTS: Intravenous injection of the TRPV-1 agonist capsaicin induced a dose-dependent increase in Evans blue accumulation in the rat pancreas (P < 0.05 vs. vehicle control). Capsaicin 53-62 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 38-44 15837818-2 2005 Activation of TRPV1 contributes to the pronociceptive effects of capsaicin, protons, heat, and various endogenous lipid agonists such as anandamide and N-arachidonoyl-dopamine. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-19 15802291-7 2005 These results suggest that both the TRPV1 and P2X receptors mediate the sensory transduction of ROS, especially H2O2 and .OH, by capsaicin-sensitive vagal lung afferent fibres. Capsaicin 129-138 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 36-41 15854744-1 2005 Capsaicin opens the TRPV1 channel, a cation channel that depolarizes and activates nociceptive neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 20-25 15854744-2 2005 Following this initial activation, neurons become desensitized to subsequent applications of capsaicin as well as to other noxious stimuli, a phenomenon attributed primarily to the entry of Ca2+ ions through the open TRPV1 channel. Capsaicin 93-102 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 217-222 15746091-13 2005 Stimulation of TRPV1 by capsaicin down-regulates VACCs by dephosphorylation through Ca(2+)-dependent activation of calcineurin. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 15-20 15653710-5 2005 The stimulation of C fibers by 2-APB was attenuated but not abolished by capsazepine, a selective antagonist of the TRPV1, which completely blocked the response to capsaicin in these C fiber afferents. Capsaicin 164-173 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 116-121 15887113-1 2005 BACKGROUND & AIMS: Clostridium difficile toxin A is a potent intestinal inflammatory agent that has been shown to act at least partially by neurogenic mechanisms involving activation of the transient receptor potential vanilloid 1 (TRPV1) (capsaicin) receptor. Capsaicin 244-253 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 236-241 15857679-1 2005 The vanilloid receptor (TRPV1 or VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid, and high temperature. Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 15857679-1 2005 The vanilloid receptor (TRPV1 or VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid, and high temperature. Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-36 15823259-2 2005 We recently found that depletion of capsaicin-sensitive afferents by systemic treatment with a potent TRPV1 agonist, resiniferotoxin, in adult rats produces long-lasting paradoxical changes in mechanical and thermal sensitivities, which resemble the unique clinical features of postherpetic neuralgia. Capsaicin 36-45 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 102-107 15615864-4 2005 AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-117 15615864-4 2005 AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-117 15615864-4 2005 AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-117 15615864-4 2005 AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-117 16041554-1 2005 Vanilloid receptor type 1 (TRPV1) is expressed in a capsaicin-sensitive and peptide-containing sub-population of primary sensory nerves that in the rat stomach seems involved in regulation of chlorhydropeptic secretion and gastroprotection. Capsaicin 52-61 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 27-32 15931076-3 2005 Further, such a manipulation modified the sensitivity to the TRPV1 receptor-antagonist capsazepine and altered the dependence of the capsaicin effect on extracellular pH. Capsaicin 133-142 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-66 15821751-2 2005 2 In G3, vasorelaxation to THC was inhibited by pertussis toxin, but was unaffected by the CB1 receptor antagonist, AM251 (1 microM), incubation with the TRPV1 receptor agonist capsaicin (10 microM, 1 h), the TRPV1 receptor antagonist capsazepine (10 microM) or de-endothelialisation. Capsaicin 177-186 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 154-159 15562294-3 2005 In brain slices, application of the TRPV1 receptor agonist capsaicin increased the firing rate of rat dopamine neurons and in a proportion of tested cells (44%) it also induced a bursting behavior. Capsaicin 59-68 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 36-41 15869474-4 2005 Activation of peripheral nociceptors in vivo using intraplantar injections of capsaicin in anaesthetized rats induced a rapid onset and time-dependent increase in p-Akt Ser 473 in small- and medium-sized DRG, predominantly TRPV1-positive neurons. Capsaicin 78-87 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 223-228 15615864-9 2005 AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain. Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-37 15781048-0 2005 Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 88-93 15781048-1 2005 The activation of transient receptor potential vanilloid receptor 1 (TRPV1) by capsaicin in rat brain stimulates gastric acid secretion via tachykinin NK2 receptors and the vagus cholinergic nerve, but the involvement of other receptor systems has not been elucidated. Capsaicin 79-88 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-67 15781048-1 2005 The activation of transient receptor potential vanilloid receptor 1 (TRPV1) by capsaicin in rat brain stimulates gastric acid secretion via tachykinin NK2 receptors and the vagus cholinergic nerve, but the involvement of other receptor systems has not been elucidated. Capsaicin 79-88 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 15781048-9 2005 injection of anandamide (an endogenous ligand of TRPV1 and cannabinoid receptors, 30 and 100 nmol) stimulated gastric acid secretion, and the response was inhibited by an antagonist of TRPV1 and in the capsaicin-treated rats, but not by an antagonist of cannabinoid receptors. Capsaicin 202-211 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 49-54 15781048-10 2005 In conclusion, the TRPV1 system, which is activated by capsaicin and anandamide, is preferentially coupled with non-NMDA and GABA(A) receptor systems in the brain and stimulates gastric acid secretion in rats. Capsaicin 55-64 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 19-24 15220301-3 2004 Capsaicin depolarizes thin sensory afferent nerves that have vanilloid type 1 receptors (VR1). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-92 15492487-6 2005 The present results demonstrate that both 3beta-HSD and TRPV1 are markers for neurodegeneration and neuroregeneration in capsaicin-sensitive primary afferent neurons, and that NGF is an effective tool to induce recovery after peripheral nerve injury. Capsaicin 121-130 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-61 15659603-7 2005 Surprisingly, CZP and AM251 reversed HU210- or CAP-induced neurotoxicity by inhibiting Ca2+ influx, respectively, suggesting the existence of functional cross talk between TRPV1 and CB1 receptors. Capsaicin 47-50 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 172-177 15655292-2 2005 The gastrointestinal protective effects of lafutidine are mediated by capsaicin-sensitive neurons, where capsaicin excites neurons by opening a member of the transient receptor potential channel family (TRPV1). Capsaicin 70-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 203-208 15655292-2 2005 The gastrointestinal protective effects of lafutidine are mediated by capsaicin-sensitive neurons, where capsaicin excites neurons by opening a member of the transient receptor potential channel family (TRPV1). Capsaicin 105-114 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 203-208 15471852-7 2004 1) Overexpression of PKCmu enhanced the response of rVR1 to capsaicin and low pH, and expression of a dominant negative variant of PKCmu reduced the response of rVR1. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 52-56 15471852-12 2004 6) Mutation of S116A in rVR1 blocked both the phosphorylation of rVR1 by PKCmu and the enhancement by PKCmu of the rVR1 response to capsaicin. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-28 15492017-1 2004 As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity. Capsaicin 37-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 134-137 15492017-1 2004 As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity. Capsaicin 37-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-214 15492017-1 2004 As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity. Capsaicin 37-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 339-345 15492017-1 2004 As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity. Capsaicin 48-80 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 134-137 15337299-1 2004 Capsaicin, a pungent ingredient of chili pepper, activates vanilloid receptor subtype 1 (VR1), which is a nonselective cation channel with high Ca(2+) permeability. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-92 15337299-4 2004 Capsaicin at concentrations above 100 microM induced an increase in intracellular free Ca(2+) concentrations by influx from extracellular spaces, and the effect was blocked by capsazepine, a selective antagonist of VR1. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 215-218 15337299-7 2004 VR1 in PC12 cells showed different characters from that in sensory neurons; capsaicin concentration-dependency and heat- and nerve growth factor-sensitivities. Capsaicin 76-85 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-3 15520319-3 2004 Previous studies suggest that (1) capsaicin stimulates muscle metabosensitive vanilloid receptor subtype 1 (VR1), inducing a neurally mediated pressor response, and (2) activation of ATP-sensitive P2X receptors enhances the pressor response seen when muscle mechanoreceptors are engaged by muscle stretch. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 78-106 15520319-3 2004 Previous studies suggest that (1) capsaicin stimulates muscle metabosensitive vanilloid receptor subtype 1 (VR1), inducing a neurally mediated pressor response, and (2) activation of ATP-sensitive P2X receptors enhances the pressor response seen when muscle mechanoreceptors are engaged by muscle stretch. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 108-111 15525465-6 2004 Pretreatment with ruthenium red (100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR1), blocked the effect of capsaicin on CBA. Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 67-95 15525465-6 2004 Pretreatment with ruthenium red (100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR1), blocked the effect of capsaicin on CBA. Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 97-100 15525465-9 2004 The facilitatory action of capsaicin may be attributed to the opening of K(ATP) channels mediated by VR1. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 101-104 15356216-0 2005 Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. Capsaicin 39-51 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 64-109 15356216-0 2005 Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential. Capsaicin 39-51 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 111-116 15492487-0 2005 Differential regulation of 3-beta-hydroxysteroid dehydrogenase and vanilloid receptor TRPV1 mRNA in sensory neurons by capsaicin and NGF. Capsaicin 119-128 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 86-91 15492487-3 2005 The expression of TRPV1, a specific marker of capsaicin-sensitive small sensory neurons connected to C- and Adelta-fibers, was markedly reduced 3 days after the capsaicin treatment. Capsaicin 46-55 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-23 15492487-3 2005 The expression of TRPV1, a specific marker of capsaicin-sensitive small sensory neurons connected to C- and Adelta-fibers, was markedly reduced 3 days after the capsaicin treatment. Capsaicin 161-170 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 18-23 15659603-1 2005 Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry. Capsaicin 113-122 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-77 15659603-1 2005 Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry. Capsaicin 113-122 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-84 15659603-1 2005 Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry. Capsaicin 113-122 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 100-103 15659603-1 2005 Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry. Capsaicin 124-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-77 15513920-7 2005 Capsaicin-induced desensitization of VR1 was down-regulated, whereas VR1 re-sensitization was up-regulated in DRG neurons from diabetic rats. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-40 15289965-5 2005 Intramuscular injection of capsaicin (0.05 and 0.1%) produced a reduction in a MM-induced C1 neuronal activity in a dose-dependent manner and this effect was antagonized by pretreatment with an antagonist of VR1, capsazepine. Capsaicin 27-36 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 208-211 15459754-0 2004 Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death. Capsaicin 76-85 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 58-61 15556833-4 2004 Pretreatment with the TRPV1 antagonist, capsazepine (10 microM) and ruthenium red (3 microM) significantly reduced the relaxation response to capsaicin by 78% (P<0.01) and 38% (P<0.05), respectively. Capsaicin 142-151 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-27 15494172-4 2004 The inhibitory action of PS on the capsaicin-induced current may provide a basis for reducing capsaicin receptor-mediated nociception. Capsaicin 35-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 94-112 15595420-0 2004 Decreased pain sensitivity of capsaicin-treated rats results from decreased VR1 expression. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 76-79 15220301-9 2004 Anandamide (an endogenous substance that activates VR1) induced the same change in blood pressure as did capsaicin. Capsaicin 105-114 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-54 15201344-7 2004 The inhibitory action of DHEA on the capsaicin-induced current may provide a basis for reducing capsaicin receptor-mediated nociception. Capsaicin 37-46 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-114 15488288-7 2004 These findings, taken together, indicate that FK506 application on inflamed skin may activate nociceptive C-fibers, which bear bradykinin receptors and capsaicin-sensitive heat transducer of TRP family, TRPV1. Capsaicin 152-161 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 203-208 15488290-3 2004 The antagonists FR173657 and capsazepine confirmed bradykinin B2 and vanilloid VR1 receptors mediated the responses to bradykinin and capsaicin, respectively. Capsaicin 134-143 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 79-82 15385613-3 2004 Intradermal injection of capsaicin and NGF produce heat hyperalgesia by activating their respective TRPV1 (transient receptor potential vanilloid receptor-1) and TrkA receptors on nociceptor sensory nerve terminals. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 100-105 15385613-3 2004 Intradermal injection of capsaicin and NGF produce heat hyperalgesia by activating their respective TRPV1 (transient receptor potential vanilloid receptor-1) and TrkA receptors on nociceptor sensory nerve terminals. Capsaicin 25-34 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 107-156 15385613-11 2004 In acutely dissociated DRG neurons, the capsaicin-induced TRPV1 current was strikingly potentiated by NGF, and this potentiation was completely blocked by PI3K inhibitors and primarily suppressed by MEK inhibitors. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 58-63 15148262-10 2004 6 Noladin ether evoked a concentration-dependent increase in intracellular Ca2+ concentration in TRPV1-HEK293 cells at 10 microm (36.5+/-3.2% of maximal capsaicin-induced response), but it was a less potent agonist than both capsaicin and anandamide and at 1 microm it was essentially inactive. Capsaicin 153-162 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 97-102 15358238-1 2004 Capsaicin-sensitive afferent neurons including transient receptor potential vanilloid subfamily 1, TRPV1, and neurohormonal peptides participate in the physiological regulation of pancreatic endocrine. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 99-104 15358238-4 2004 Capsaicin (10(-11)-10(-9) M) dose-dependently increased insulin secretion from RIN cells, and this effect was inhibited by either a TRPV1 inhibitor capsazepine or EDTA. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 132-137 15084474-4 2004 PP2 also abolished currents in human embryonic kidney-293 cells transfected with rat TRPV1, whereas cotransfection of TRPV1 with v-Src resulted in fivefold increase in capsaicin-induced currents. Capsaicin 168-177 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 118-123 15084474-5 2004 In cells transfected with dominant-negative c-Src and TRPV1, capsaicin-induced currents were decreased by approximately fourfold. Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 54-59 15275770-9 2004 Significant capsaicin responses even at 8 degrees C suggest a contribution of noxious-cold sensitive neurons known to coexpress CGRP and the capsaicin receptor. Capsaicin 12-21 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 141-159 15189776-2 2004 Greater relaxant responses in females were also induced by the vanilloid TRPV1 receptor agonist capsaicin (0.01 to 10 microM), whereas no sex differences were observed for the relaxations caused by either acetylcholine or sodium nitroprusside. Capsaicin 96-105 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 73-78 15311112-6 2004 caused a depressor effect concomitantly with an increase in the plasma concentration of CGRP in a dose-dependent manner, which was blocked by capsaicin (used to deplete the CGRP from sensory nerves) or capsazepine (a competitive VR1 antagonist), causing an approximately 85% and approximately 80% change in mean arterial pressure, respectively, and by either of them, causing an approximately 90% elevation of plasma CGRP. Capsaicin 142-151 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 229-232 15277316-0 2004 The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints. Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-92 15277316-10 2004 Rather than a classic CB receptor pathway, ACEA exerts its vasomotor influence by acting via TRPV(1) receptors located on the terminal branches of capsaicin-sensitive afferent nerves innervating the joint. Capsaicin 147-156 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-100 15148262-10 2004 6 Noladin ether evoked a concentration-dependent increase in intracellular Ca2+ concentration in TRPV1-HEK293 cells at 10 microm (36.5+/-3.2% of maximal capsaicin-induced response), but it was a less potent agonist than both capsaicin and anandamide and at 1 microm it was essentially inactive. Capsaicin 225-234 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 97-102 15157689-1 2004 Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin receptor (TRPV1) expressed in non-neuronal host cells, and natively, in cultured dorsal root ganglion cells. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 166-184 15157689-1 2004 Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin receptor (TRPV1) expressed in non-neuronal host cells, and natively, in cultured dorsal root ganglion cells. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 186-191 15120568-2 2004 In this study, we have measured the effects of various neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and -4) on recombinant rat VR1-mediated intracellular calcium rise in response to capsaicin in VR1/C6 cells. Capsaicin 224-233 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 169-172 15120568-3 2004 Our results clearly show that all neurotrophins sensitize the VR1 to capsaicin. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-65 15135917-2 2004 The EC(50) of capsaicin and OLDA on (45)Ca accumulation of rTRPV1-expressing HT5-1 cells was 36 nM and 1.8 microM, respectively. Capsaicin 14-23 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 59-65 15135917-5 2004 Repeated application of OLDA and capsaicin caused similar desensitization in the Ca(2+) transients both in cultured neurons and rTRPV1-transfected HT5-1 cells. Capsaicin 33-42 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 128-134 15135917-9 2004 It is concluded that on TRPV1 capsaicin receptors OLDA is 50 times less potent than capsaicin and it might serve as an endogenous ligand for TRPV1 in the rat, but more likely in humans. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-29 15135917-9 2004 It is concluded that on TRPV1 capsaicin receptors OLDA is 50 times less potent than capsaicin and it might serve as an endogenous ligand for TRPV1 in the rat, but more likely in humans. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 141-146 15135921-1 2004 The TRPV1 receptor, previously called VR1 receptor, is a non-selective cation channel gated by capsaicin, noxious heat, protons and anandamide. Capsaicin 95-104 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 15140635-0 2004 Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats. Capsaicin 72-81 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-35 15174761-2 2004 Vanilloid receptor subtype 1 (VRI) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors. Capsaicin 112-121 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-34 15006899-7 2004 The TRPV1 antagonists iodo-resiniferatoxin (I-RTX) and capsazepine (CPZ) each obtunded AEA-, NADA-, ACEA- and capsaicin (CAP)-evoked CGRP release with individually equivalent IC(50)"s for each of the compounds (I-RTX IC(50) range=2.6-4.0 nM; CPZ IC(50) range=523-1140 microM). Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 15475687-1 2004 The vanilloid receptor VR1 (TRPV1) is a temperature- and capsaicin-sensitive cation channel expressed by a class of primary afferents involved in nociception. Capsaicin 57-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 23-26 15475687-1 2004 The vanilloid receptor VR1 (TRPV1) is a temperature- and capsaicin-sensitive cation channel expressed by a class of primary afferents involved in nociception. Capsaicin 57-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 28-33 14960593-3 2004 Mutation of rat TRPV1 at three positions in the S3 to S4 region, to the corresponding human amino acid residues I514M, V518L, and M547L decreased the IC(50) values for capsazepine inhibition of the pH 5.5 response from >10,000 nm to 924 +/- 241 nm in [Ca(2+)](i) assays and increased capsazepine inhibition of the capsaicin response to levels seen for human TRPV1. Capsaicin 317-326 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 16-21 15006899-7 2004 The TRPV1 antagonists iodo-resiniferatoxin (I-RTX) and capsazepine (CPZ) each obtunded AEA-, NADA-, ACEA- and capsaicin (CAP)-evoked CGRP release with individually equivalent IC(50)"s for each of the compounds (I-RTX IC(50) range=2.6-4.0 nM; CPZ IC(50) range=523-1140 microM). Capsaicin 121-124 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-9 14625038-3 2003 Labeled neurons in lamina I and III/IV were patch clamped and the vanilloid receptor 1 (TRPV1) agonist, capsaicin, was applied to evoke glutamate release from central terminals of peripheral nociceptors. Capsaicin 104-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-86 15098930-4 2004 Capsaicin (CPS), the VRI receptor agonist, led to an increase in intracellular calcium ion, and this effect was blocked by pretreatment with VR1 receptor antagonist capsazepin (CPZ). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 141-144 15098930-4 2004 Capsaicin (CPS), the VRI receptor agonist, led to an increase in intracellular calcium ion, and this effect was blocked by pretreatment with VR1 receptor antagonist capsazepin (CPZ). Capsaicin 11-14 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 141-144 15098930-6 2004 These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system. Capsaicin 28-31 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-71 15098930-6 2004 These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system. Capsaicin 127-130 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 68-71 14975683-7 2004 The neonatal treatment with capsaicin, polygodial or drimanial significantly decreased [3H]-resiniferatoxin binding sites in the rat spinal cord, but only capsaicin neonatal treatment significantly reduced the expression of TRPV1 in dorsal root ganglia (DRG) when assessed by Western blot. Capsaicin 28-37 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 224-229 14975683-7 2004 The neonatal treatment with capsaicin, polygodial or drimanial significantly decreased [3H]-resiniferatoxin binding sites in the rat spinal cord, but only capsaicin neonatal treatment significantly reduced the expression of TRPV1 in dorsal root ganglia (DRG) when assessed by Western blot. Capsaicin 155-164 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 224-229 14742669-2 2004 IBTU competitively inhibited 45Ca2+ uptake into CHO cells heterologously expressing rat TRPV1, whether induced by capsaicin or resiniferatoxin (Ki = 99 +/- 23 and 93 +/- 34 nM, respectively). Capsaicin 114-123 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 88-93 14625038-3 2003 Labeled neurons in lamina I and III/IV were patch clamped and the vanilloid receptor 1 (TRPV1) agonist, capsaicin, was applied to evoke glutamate release from central terminals of peripheral nociceptors. Capsaicin 104-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 88-93 12946940-2 2003 Nodose neurons were classified as A or C type on the basis of the characteristics of the Na+ current, a hyperpolarization-activated current, and sensitivity to a low concentration of capsaicin to ascertain the presence of vanilloid receptor 1 that has been associated with C-type neurons in sensory ganglia. Capsaicin 183-192 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 222-242 12815018-11 2003 Pretreatment with the VR1 receptor antagonist, capsazepine (10 nmol in 0.4 microl), into the dPAG blocked the capsaicin-induced hyperalgesia as well as the corresponding changes in on- and off-cell activity. Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-25 12949222-5 2003 This capsaicin-induced vasodilatation was abolished by capsazepine, a transient receptor potential vanilloid 1 (TRPV1) receptor antagonist, and by hCGRP8-37, a calcitonin gene-related peptide (CGRP) receptor antagonist. Capsaicin 5-14 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-110 12949222-5 2003 This capsaicin-induced vasodilatation was abolished by capsazepine, a transient receptor potential vanilloid 1 (TRPV1) receptor antagonist, and by hCGRP8-37, a calcitonin gene-related peptide (CGRP) receptor antagonist. Capsaicin 5-14 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-117 12721336-2 2003 The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive sensory neurons and is activated by a wide array of pain-producing stimuli, including capsaicin, noxious heat, and low pH. Capsaicin 176-185 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-24 12829722-11 2003 Furthermore, epicardial application of iodo-RTX, a highly specific antagonist of VR1 receptors, blocked capsaicin- but not bradykinin-induced sympathoexcitatory responses. Capsaicin 104-113 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 81-84 12946582-1 2003 The vanilloid receptor VR1 renders a group of primary afferents that express it sensitive to noxious heat and capsaicin, and is thus an important marker for nociceptors. Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 23-26 12963499-1 2003 Vanilloid receptors subtype 1 (VR1), a nonselective cation channel responsive to capsaicin, protons, and noxious heat, has been recently identified in not only neural but also non-neural cells. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-34 12948856-5 2003 This compound inhibited capsaicin-induced Ca(2+) influx into rVR1-HEK293 cells with a pK(B) value of 6.8+/-0.3. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 61-65 12869637-1 2003 The vanilloid receptor VR1 is a polymodal nociceptor sensitive to capsaicin, protons, and heat. Capsaicin 66-75 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 23-26 12906841-5 2003 These results suggests that vanilloid receptor 1 on capsaicin-sensitive sensory nerves plays an important role in the modulation of the delayed cardioprotection induced by heat stress in rats. Capsaicin 52-61 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 28-48 12825950-1 2003 Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells. Capsaicin 213-222 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-86 12825950-1 2003 Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells. Capsaicin 213-222 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 230-233 12721336-2 2003 The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive sensory neurons and is activated by a wide array of pain-producing stimuli, including capsaicin, noxious heat, and low pH. Capsaicin 176-185 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-29 12721336-4 2003 N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropryazine-1(2H)-carbox-amide (BCTC) is a recently described inhibitor of capsaicin- and acid-mediated currents at rat VR1. Capsaicin 133-142 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 178-181 12721338-1 2003 Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors. Capsaicin 19-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 109-129 12721338-1 2003 Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors. Capsaicin 19-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 131-134 12721338-2 2003 Although blockade of capsaicin-induced VR1 activation has been demonstrated in vitro and in vivo with the antagonist capsazepine, efficacy in rat models of chronic pain has not been observed with this compound. Capsaicin 21-30 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 39-42 12721338-4 2003 Similar to capsazepine, this compound inhibits capsaicin-induced activation of rat VR1 with an IC50 value of 35 nM. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-86 15320697-1 2003 Capsaicin (8-methyl-N-vannillyl-6-nonenamide), via binding to the vanilloid receptor subtype 1 (VR1), stimulates a subpopulation of primary afferent neurons that project to cardiovascular and renal tissues. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-94 12832498-7 2003 Capsaicin-evoked Ca2+ transients were completely blocked by the vanilloid receptor 1 antagonist capsazepine (100 microm). Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 64-84 15320697-1 2003 Capsaicin (8-methyl-N-vannillyl-6-nonenamide), via binding to the vanilloid receptor subtype 1 (VR1), stimulates a subpopulation of primary afferent neurons that project to cardiovascular and renal tissues. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 96-99 15320697-3 2003 Regarding the latter, these neurons release stored neuropeptides through a calcium-dependent mechanism via the binding of capsaicin to the VR1. Capsaicin 122-131 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 139-142 12709508-1 2003 Capsaicin, the pungent substance in hot peppers, evokes a sensation of burning pain by stimulating the vanilloid receptor 1 (VR1) on primary afferent neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-128 12679376-4 2003 The elevation in mEPSC frequency occurred at concentrations of capsaicin (100 nM) that did not alter the distribution of mEPSC amplitudes and was abolished by a dorsal rhizotomy, demonstrating that capsaicin acts via presynaptic VR1 receptors localized on primary afferents. Capsaicin 198-207 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 229-232 12709508-5 2003 The finding that VR1 is expressed not only in primary afferents but also in oral epithelial cells suggests that it is of great importance in the perception of capsaicin, heat, and acid in the mouth. Capsaicin 159-168 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 17-20 12716921-3 2003 The VR1 agonist capsaicin increased the frequency of both TTX-sensitive and -insensitive spontaneous EPSCs (sEPSCs) without affecting their amplitude, suggesting a presynaptic site of action. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-7 12716921-6 2003 The VR1 antagonists capsazepine and iodoresiniferatoxin (IRTX) blocked the effects of capsaicin. Capsaicin 86-95 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-7 12414119-1 2002 Pungent sensation of hot peppers is thought to be mediated by vanilloid receptor subtype-1 (VR1), which can be activated by capsaicin, but there is little information regarding its histological localization in the tongue. Capsaicin 124-133 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-90 12562891-5 2003 Application of the VR1 receptor agonist capsaicin (300 nM) caused a 4200 % increase in the mEPSC rate. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 19-22 12562891-8 2003 Co-application of the VR1 antagonist capsazepine (30 microM) completely reversed the effects of both capsaicin and anandamide. Capsaicin 101-110 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-25 12527134-1 2003 The type 1 vanilloid receptor (VR1) is a non-specific cation channel activated by capsaicin, lipoxygenase (LOX) products, heat and acid. Capsaicin 82-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 31-34 12490575-1 2003 Vanilloid receptor type 1 (VR1) (TRPV1) is a ligand-gated ion channel expressed on sensory nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin. Capsaicin 167-176 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-30 12490575-1 2003 Vanilloid receptor type 1 (VR1) (TRPV1) is a ligand-gated ion channel expressed on sensory nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin. Capsaicin 167-176 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-38 14568027-3 2003 NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 124-144 12498288-8 2002 Capsaicin evoked an increase in [Ca2+]i in rat VR1-transfected HEK293 cells, while lafutidine had no effect by itself on [Ca2+]i in these cells and did not affect the increase in [Ca2+]i evoked by capsaicin. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 47-50 12594053-6 2003 In concordance with vanilloid receptor 1 expression on these nerve terminals, the spinal sensory substance P/calcitionin gene-related peptide-IR component of the innervation of NEBs was depleted by systemic capsaicin treatment. Capsaicin 207-216 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 20-40 12658436-1 2003 The vanilloid receptor VR1 is a nonselective cation channel activated by capsaicin as well as increases in temperature and acidity, and can be viewed as molecular integrator of chemical and physical stimuli that elicit pain. Capsaicin 73-82 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 23-26 12454015-2 2003 The VR1 agonist capsaicin induced Ca(2+) mobilization from intracellular stores in the absence of extracellular Ca(2+), and this release was inhibited by the VR1 antagonist capsazepine but was unaffected by the phospholipase C inhibitor xestospongins, indicating that Ca(2+) mobilization was dependent on capsaicin receptor binding and was not due to intracellular inositol-1,4,5-trisphosphate generation. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-7 12454015-2 2003 The VR1 agonist capsaicin induced Ca(2+) mobilization from intracellular stores in the absence of extracellular Ca(2+), and this release was inhibited by the VR1 antagonist capsazepine but was unaffected by the phospholipase C inhibitor xestospongins, indicating that Ca(2+) mobilization was dependent on capsaicin receptor binding and was not due to intracellular inositol-1,4,5-trisphosphate generation. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 158-161 12454015-4 2003 The main part of the capsaicin-releasable Ca(2+) store was insensitive to thapsigargin, a selective endoplasmic reticulum Ca(2+)-ATPase inhibitor, suggesting that VR1 might be predominantly localized to a thapsigargin-insensitive endoplasmic reticulum Ca(2+) store. Capsaicin 21-30 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 163-166 12473388-1 2003 This study compared the actions of members of five different chemical classes of vanilloid agonists at the recombinant rat vanilloid VR1 receptor expressed in HEK293 cells, and at endogenous vanilloid receptors on dorsal root ganglion cells and sensory nerves in the rat isolated mesenteric arterial bed. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 133-136 12473388-5 2003 In VR1-HEK293 cells and dorsal root ganglion neurones, Ca(2+) responses were induced by resiniferatoxin>capsaicin=olvanil>PPAHV; all four were full agonists. Capsaicin 107-116 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 3-6 12473388-8 2003 Olvanil had a Hill coefficient of approximately 1 whilst capsaicin, resiniferatoxin and PPAHV had Hill coefficients of approximately 2 in VR1-HEK293 cells. Capsaicin 57-66 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 138-141 12473388-10 2003 These data show that resiniferatoxin, capsaicin, olvanil and PPAHV, but not scutigeral and isovelleral, are agonists at recombinant rat VR1 receptors and endogenous vanilloid receptors on dorsal root ganglion neurones and in the rat mesenteric arterial bed. Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 136-139 14568027-3 2003 NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 146-149 12453933-5 2002 METHODS: Using a Flurometric Imaging Plate Reader (FLIPR), calcium imaging has been used to study the effects of several vanilloid and cannabinoid ligands in rat VR1-transfected HEK293 (rVR1-HEK) cells and in DRG cells. Capsaicin 121-130 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 162-165 12453933-10 2002 Reapplication of VR1 agonists significantly inhibited a subsequent challenge to either capsaicin or anandamide in either cell type, whilst pre-exposure to cannabinoid agonists were without effect. Capsaicin 87-96 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 17-20 12414119-1 2002 Pungent sensation of hot peppers is thought to be mediated by vanilloid receptor subtype-1 (VR1), which can be activated by capsaicin, but there is little information regarding its histological localization in the tongue. Capsaicin 124-133 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 92-95 12414119-10 2002 Although VR1-immunoreactivity was not observed in taste-bud cells, our findings that a large number of VR1-IR fibers concentrated in the taste papillae suggest that capsaicin easily reaches the VR1 nerve terminals because of its lipophilic nature. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-12 12414119-10 2002 Although VR1-immunoreactivity was not observed in taste-bud cells, our findings that a large number of VR1-IR fibers concentrated in the taste papillae suggest that capsaicin easily reaches the VR1 nerve terminals because of its lipophilic nature. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-106 12414119-10 2002 Although VR1-immunoreactivity was not observed in taste-bud cells, our findings that a large number of VR1-IR fibers concentrated in the taste papillae suggest that capsaicin easily reaches the VR1 nerve terminals because of its lipophilic nature. Capsaicin 165-174 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-106 14599363-3 2002 HEK-293 cells, stably expressing rVR1 or hVR1, exhibited dose-dependent increases in [Ca(++)](i) when challenged with capsaicin (EC(50)s congruent with 10 nM). Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 33-37 12237342-1 2002 The vanilloid receptor VR1 has attracted great interest as a sensory transducer for capsaicin, protons, and heat, and as a therapeutic target. Capsaicin 84-93 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 23-26 12237342-12 2002 We conclude that JYL1421 is a competitive antagonist of rVR1, blocking response to all three of the agonists (capsaicin, heat, and protons) with enhanced potency relative to capsazepine. Capsaicin 110-119 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-60 11930156-4 2002 P2X and VR1 are membrane receptors activated by ATP and capsaicin, respectively, and are thought to be involved in inflammation-related nociception. Capsaicin 56-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 8-11 12205187-6 2002 The effects of capsaicin (1 microM) were abolished by the VR1 receptor antagonists capsazepine (10 microM) and iodoresiniferatoxin (300 nM). Capsaicin 15-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 58-61 11685550-1 2001 Vanilloid receptor subtype 1 (VR1) is a non-selective cation channel detected on sensory neurons that is sensitive to capsaicin, the main pungent ingredient of hot chili pepper. Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-28 11906962-9 2002 We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively. Capsaicin 160-169 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 112-140 11906962-9 2002 We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively. Capsaicin 160-169 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 142-145 11927161-1 2002 Previous findings have shown that the capsaicin sensitivity of sensory fibres is due to the expression of a specific membrane protein, the vanilloid receptor type 1 (VR1). Capsaicin 38-47 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 139-169 12031340-3 2002 Here we report that dithiothreitol (DTT) (2-60 mM), an agent that maintains -SH groups of cysteines in a reduced state, greatly facilitates membrane currents induced by noxious heat or capsaicin (1 microM) in cultured DRG neurones from the rat and in VR1-transfected HEK293 cells. Capsaicin 185-194 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 251-254 12435419-1 2002 Capsaicin acting on the vanilloid type 1 receptor (VR1) excites a subset of primary sensory neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-49 12435419-1 2002 Capsaicin acting on the vanilloid type 1 receptor (VR1) excites a subset of primary sensory neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-54 11588121-13 2001 Capsazepine, ruthenium red, or acute VR1 desensitization by capsaicin-pretreatment, markedly attenuated the reflex CVR responses evoked by anandamide and capsaicin (P< 0.05; paired Student"s t-test). Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-40 11588121-13 2001 Capsazepine, ruthenium red, or acute VR1 desensitization by capsaicin-pretreatment, markedly attenuated the reflex CVR responses evoked by anandamide and capsaicin (P< 0.05; paired Student"s t-test). Capsaicin 154-163 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-40 11703449-9 2001 We conclude therefore that other heat-activated ion channels than VR1 and VRL1 in capsaicin-sensitive and -insensitive nerve fibres may cause excitation, axonal Ca++ influx and subsequent CGRP release. Capsaicin 82-91 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-69 11524156-1 2001 The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-24 11524156-1 2001 The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-29 12182898-1 2002 Capsaicin acts on the vanilloid receptor subtype 1, a noxious heat-gated cation channel located on a major subgroup of nociceptive primary afferent neurons. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-50 11606325-9 2001 CBD (10 microM) desensitized VR1 to the action of capsaicin. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 29-32 11685550-1 2001 Vanilloid receptor subtype 1 (VR1) is a non-selective cation channel detected on sensory neurons that is sensitive to capsaicin, the main pungent ingredient of hot chili pepper. Capsaicin 118-127 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 30-33 11595435-4 2001 (1) Cloning the capsaicin VR-1 receptor (an ion channel-coupled receptor) and raising the VR-1 knockout mice provided a definite molecular background for the existence of capsaicin-sensitive afferents with both sensory and mediator releasing functions in the stomach. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 26-30 11474544-5 2001 In rVR1-transfected HEK293 cells, acidic conditions enhanced the affinities of capsaicin and capsazepine at rVR1, but did not affect the potency of carbachol at endogenous muscarinic receptors. Capsaicin 79-88 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 3-7 11474544-5 2001 In rVR1-transfected HEK293 cells, acidic conditions enhanced the affinities of capsaicin and capsazepine at rVR1, but did not affect the potency of carbachol at endogenous muscarinic receptors. Capsaicin 79-88 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 108-112 11474544-8 2001 In conclusion, a decrease in pH (to 6.9 and 6.3) enhances the affinity of capsaicin at rVR1, but inhibits sensory neurotransmission in the rat mesenteric arterial bed. Capsaicin 74-83 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 87-91 11301059-2 2001 In whole-cell patch clamp studies, capsaicin (10 microM) elicited a slowly activating/deactivating inward current in human embryonic kidney (HEK293) cells stably expressing human vanilloid VR1 receptor, which exhibited pronounced outward rectification (reversal potential -2.1+/-0.2 mV) and was abolished by capsazepine (10 microM). Capsaicin 35-44 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 189-192 11160380-8 2001 Results indicate that stimulation of VR-1 with high concentrations of AEA excites central terminals of capsaicin-sensitive DRG neurons, thus causing neuropeptide release in the dorsal spinal cord. Capsaicin 103-112 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 37-41 11124144-4 2001 Capsaicin-evoked CGRP release from adrenal afferents was blocked by capsazepine, a competitive antagonist for the capsaicin receptor, or by removal of extracellular calcium. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 114-132 11514026-3 2001 Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-38 11514026-3 2001 Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation. Capsaicin 160-169 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-38 11514026-3 2001 Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation. Capsaicin 160-169 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 35-38 11489540-8 2001 Both the VR1 immunoreactivity and the receptor density of [3H]-RTX binding sites significantly reduced by the application of capsaicin for prolonged periods of time in the mucosa of rats. Capsaicin 125-134 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 9-12 11448475-0 2001 Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide. Capsaicin 105-114 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 62-65 11448475-3 2001 In this study, we have measured capsaicin- and anandamide-induced elevations in intracellular calcium concentrations ([Ca(2+)](i)) in fura-2 loaded HEK293 cells stably expressing the rat VR1 receptor at 22, 37 and 50 degrees C. Both capsaicin and anandamide produced a concentration-dependent elevation in [Ca(2+)](i) at all temperatures. Capsaicin 32-41 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 187-190 11448475-3 2001 In this study, we have measured capsaicin- and anandamide-induced elevations in intracellular calcium concentrations ([Ca(2+)](i)) in fura-2 loaded HEK293 cells stably expressing the rat VR1 receptor at 22, 37 and 50 degrees C. Both capsaicin and anandamide produced a concentration-dependent elevation in [Ca(2+)](i) at all temperatures. Capsaicin 233-242 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 187-190 11553280-1 2001 The cloned vanilloid receptor VR1 can be activated by capsaicin and by thermal stimuli. Capsaicin 54-63 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 30-33 11408034-9 2001 Finally, stimulation with capsaicin of cells expressing rat vanilloid VR1 receptors led to anandamide formation. Capsaicin 26-35 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-73 11426844-3 2001 It is concluded that, in the rat heart, capsaicin acting on VR1 capsaicin receptors elicits a release of endothelin from the sensory nerve terminals. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 60-63 11125018-4 2001 The pharmacology of recombinant rodent VR1 and the endogenous rat VR1 was indistinguishable when measuring displacement of [125I]RTX binding (i.e., the following rank order of affinity was observed: RTX > I-RTX > olvanil > capsaicin > capsazepine). Capsaicin 232-241 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 39-42 11125018-4 2001 The pharmacology of recombinant rodent VR1 and the endogenous rat VR1 was indistinguishable when measuring displacement of [125I]RTX binding (i.e., the following rank order of affinity was observed: RTX > I-RTX > olvanil > capsaicin > capsazepine). Capsaicin 232-241 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 66-69 11125018-5 2001 Capsaicin and RTX induced large nondesensitizing currents in Xenopus laevis oocytes expressing VR1 (EC50 values were 1300 nM and 0.2 nM, respectively), whereas I-RTX induced no current per se at concentrations up to 10 microM. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 95-98 11595435-6 2001 (2) VR-1 agonists (capsaicin, resiniferatoxin, piperine) protect against gastric ulcer of the rat parallel with their sensory stimulating potencies. Capsaicin 19-28 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 4-8 11226681-1 2001 The cloning of the receptor for capsaicin, vanilloid receptor 1, has shown it to be non-selective cation channel with a high calcium permeability which can be opened by noxious heat as well as capsaicin. Capsaicin 32-41 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-63 11226681-1 2001 The cloning of the receptor for capsaicin, vanilloid receptor 1, has shown it to be non-selective cation channel with a high calcium permeability which can be opened by noxious heat as well as capsaicin. Capsaicin 193-202 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 43-63 11226681-2 2001 Here we compare the calcium signals produced by native and recombinant capsaicin receptors when activated by either heat or capsaicin by imaging intracellular calcium levels ([Ca2+](i)) in rat dorsal root ganglion neurons and Chinese hamster ovary cells transfected with the rat vanilloid receptor, vanilloid receptor 1. Capsaicin 71-80 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 299-319 11226681-3 2001 Vanilloid receptor 1 transfected cells and a subset of dorsal root ganglion neurons responded to both capsaicin and to heating to 50 degrees C with rapid, substantial and reversible rises in [Ca2+](i). Capsaicin 102-111 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-20 11226681-9 2001 The competitive capsaicin antagonist capsazepine (10microM) abolished [Ca2+](i) increases stimulated by capsaicin in both dorsal root ganglion neurons and vanilloid receptor 1 transfected cells. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 155-175 11226681-11 2001 In vanilloid receptor 1 transfected cells, Ruthenium Red (10microM) blocked responses to both capsaicin and heat. Capsaicin 94-103 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 3-23 11226681-13 2001 They show that heat and capsaicin responses mediated by native and recombinant capsaicin receptors are similar with respect to the characteristics and pharmacology examined, suggesting that expression of recombinant vanilloid receptor 1 in cell lines accurately reproduces the properties of the native receptor. Capsaicin 24-33 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 216-236 11095706-0 2000 The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat. Capsaicin 56-65 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 32-52 11095706-1 2000 The recently cloned rat vanilloid receptor, VR1, can be activated by capsaicin, acid, and heat. Capsaicin 69-78 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-47 11095706-4 2000 Three of the mutant channels are significantly more sensitive to capsaicin than is wild-type VR1, whereas none differed in their activation by acidic pH or temperature. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 93-96 11095706-7 2000 These data indicate that VR1 undergoes conformational changes upon capsaicin binding that it does not undergo in response to activation by protons or thermal stimuli. Capsaicin 67-76 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 25-28 11060130-16 2000 A similar difference in calcium dependence of inactivation has been reported between heat-evoked and capsaicin-induced currents through the cloned capsaicin receptor channel VR1. Capsaicin 101-110 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 174-177 11050376-1 2000 Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-123 11050376-1 2000 Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-129 11050376-1 2000 Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Capsaicin 180-189 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 103-123 11050376-1 2000 Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype. Capsaicin 180-189 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 125-129 11029625-1 2000 The heat-transducing receptor VR1 cloned from rat sensory neurons can be activated by both noxious heat and capsaicin. Capsaicin 108-117 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 30-33 10619474-0 2000 Mitochondrial calcium accumulation following activation of vanilloid (VR1) receptors by capsaicin in dorsal root ganglion neurons. Capsaicin 88-97 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 70-73 10864900-7 2000 Capsazepine, isovelleral and ruthenium red all inhibited the capsaicin (100 nM)-induced Ca(2+) response in rVR1-HEK293 cells, with pK(B) values of 7.52+/-0.08, 6.92+/-0.11 and 8.09+/-0.12 respectively (n=6 each). Capsaicin 61-70 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 107-111 11961588-4 2000 The excitatory response to intracarotid injection of capsaicin was significantly inhibited by pretreatment with the vanilloid receptor (capsaicin receptor) antagonist ruthenium red (200 mmol, 0.1 ml). Capsaicin 53-62 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 136-154 10725386-7 2000 In the central nervous system, neonatal capsaicin treatment depleted VR1 mRNA from the spinal nucleus of the trigeminal nerve, but not from other areas such as the inferior olive. Capsaicin 40-49 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-72 10856126-1 2000 Whole-cell voltage-clamp techniques were used to investigate the capsaicin-, voltage- and time-dependent properties of the rat vanilloid receptor (rVR1) stably expressed in human embryonic kidney (HEK) 293 cells. Capsaicin 65-74 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 147-151 10856126-2 2000 At a holding potential of -70 mV, application of capsaicin (0.03-30 microM) to HEK 293 cells expressing the rVR1 receptor led to the appearance of inward currents (EC50, 497 nM; Hill coefficient, nH, 2.85) which were reversibly antagonized by 10 microM capsazepine. Capsaicin 49-58 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 108-112 10869604-0 2000 Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 104-107 10619474-1 2000 Stimulation of the vanilloid (capsaicin) receptor (VR1), currently viewed as a molecular integrator of chemical and physical noxious stimuli, evoked intracellular Ca2+ transients in a capsaicin-sensitive subpopulation of rat dorsal root ganglion neurons. Capsaicin 30-39 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 51-54 10619474-9 2000 The long duration of intracellular Ca2+ decline in neurons stimulated with capsaicin, which depends on the amount of Ca2+ buffered by mitochondria, may reflect a specific mechanism of Ca2+ buffering following activation the pain receptor VR1. Capsaicin 75-84 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 238-241 10594048-7 1999 We conclude that distinct molecular entities, which are both likely to be derived from the VR1 gene product, account for the membrane responses to heat and capsaicin. Capsaicin 156-165 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 91-94 11498940-3 1999 All of 30 PGL neurons recorded responded to intracarotid injection of capsaicin with an increase in spontaneous discharge rate from 12.6 +/- 0.7 to 20.9 +/- 1.1 spikes/s (P < 0.001); (2) In 10 units, the excitatory response of PGL neurons to intracarotid injection of capsaicin was significantly inhibited by pretreatment with the vanilloid receptor (capsaicin receptor) antagonist ruthenium red (200 mmol, 0.1 ml). Capsaicin 70-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 354-372 9832191-2 1998 Bath-applied capsaicin at a concentration of 2 microM activated a slow inward current (having an amplitude of 33 pA at -70 mV), which was accompanied by an increase in the frequency of glutamatergic spontaneous excitatory postsynaptic currents (sEPSCs; by 234%); these actions were blocked by a capsaicin-receptor antagonist, capsazepine (10 microM). Capsaicin 13-22 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 295-313 10103088-1 1999 The vanilloid receptor (VR1) protein functions both as a receptor for capsaicin and a transducer of noxious thermal stimuli. Capsaicin 70-79 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 24-27 10103088-8 1999 Surprisingly, VR1-ir did not coexist substantially in nerve fibres and terminals that contain substance P and calcitonin gene-related peptide, suggesting complex mechanisms for the release of these neuropeptides in response to capsaicin application. Capsaicin 227-236 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 14-17 10024368-2 1999 The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat. Capsaicin 71-80 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 20-48 10024368-2 1999 The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat. Capsaicin 71-80 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 50-53 8246148-0 1993 Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat. Capsaicin 174-183 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 163-173 9708861-0 1998 Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 63-93 9708861-0 1998 Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 95-98 9708861-1 1998 A vanilloid receptor (VR1) has recently been cloned and shown to be a target for capsaicin, the excitotoxic component of capsicum peppers (Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D. Capsaicin 81-90 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 22-25 9378245-0 1997 Capsazocaine: a capsaicin-sensitive functional antagonist displays an argument on sensory capsaicin receptor. Capsaicin 16-25 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 90-108 35370565-6 2022 Capsaicin, a specific agonist known to activated the transient receptor potential vanilloid type 1 (TRPV1), is involved in hippocampal synaptic plasticity and memory, but the detailed mechanism is still unclear. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 53-98 34728318-14 2022 Interestingly, the analgesic effect of SZAP was weakened (reduction of PWT and TFL) when TRPV1 and P2X3 were activated by capsaicin or alpha,beta-meATP, respectively. Capsaicin 122-131 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 89-94 34929338-6 2022 By contrast, enhancement of TRPV1 expression accompanying capsaicin application, the specific TRPV1 agonists, markedly accelerated nerve cell damage, aggravated neuronal apoptosis, prompted nuclear translocation of NF-kappaB (p65), resulting in the reversion of EA pretreatment-evoked neuroprotective effect in MCAO rats. Capsaicin 58-67 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 28-33 34929338-6 2022 By contrast, enhancement of TRPV1 expression accompanying capsaicin application, the specific TRPV1 agonists, markedly accelerated nerve cell damage, aggravated neuronal apoptosis, prompted nuclear translocation of NF-kappaB (p65), resulting in the reversion of EA pretreatment-evoked neuroprotective effect in MCAO rats. Capsaicin 58-67 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 94-99 34692753-0 2021 TRPV1 Receptor-Mediated Hypoglycemic Mechanism of Capsaicin in Streptozotocin-Induced Diabetic Rats. Capsaicin 50-59 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 34692753-1 2021 Our previous research showed that capsaicin exhibits hypoglycemic effects by activating the transient receptor potential vanilloid 1 (TRPV1) channel in diabetic rats. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 92-132 34692753-1 2021 Our previous research showed that capsaicin exhibits hypoglycemic effects by activating the transient receptor potential vanilloid 1 (TRPV1) channel in diabetic rats. Capsaicin 34-43 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 134-139 34692753-3 2021 This study aimed to investigate the effect of capsaicin on the glycometabolism of streptozotocin (STZ)-induced diabetic rats by blocking the TRPV1 channel. Capsaicin 46-55 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 141-146 34692753-6 2021 It was concluded that a combined up-regulation of both TRPV1 receptors and pancreatic duodenal homeobox-1 (PDX-1) led to the hypoglycemic effect of capsaicin, which partially explains our previous observation: capsiate activating TRPV1 without showing a significant hypoglycemic effect was due to the lack of a significant up-regulation of PDX-1. Capsaicin 148-157 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 55-60 34692753-6 2021 It was concluded that a combined up-regulation of both TRPV1 receptors and pancreatic duodenal homeobox-1 (PDX-1) led to the hypoglycemic effect of capsaicin, which partially explains our previous observation: capsiate activating TRPV1 without showing a significant hypoglycemic effect was due to the lack of a significant up-regulation of PDX-1. Capsaicin 148-157 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 230-235 34470979-2 2021 We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through alpha2 receptors in cultured rat dorsal root ganglion (DRG) neurons. Capsaicin 115-124 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 56-96 34470979-2 2021 We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through alpha2 receptors in cultured rat dorsal root ganglion (DRG) neurons. Capsaicin 115-124 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 98-103 34241806-3 2021 TRPV1 is activated by capsaicin and reactive free oxygen radicals (fROS) to mediate peripheral neuropathy and neurotoxicity. Capsaicin 22-31 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 0-5 34239123-2 2021 Using cryo-EM, we have determined the structures of apo and capsaicin-bound full-length rat TRPV1 reconstituted into lipid nanodiscs over a range of temperatures. Capsaicin 60-69 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 92-97 34239123-3 2021 This has allowed us to visualize the noxious heat-induced opening of TRPV1 in the presence of capsaicin. Capsaicin 94-103 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 69-74 34113239-1 2021 Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor (TRPV1) in capsaicin-induced acute inflammatory pain and the possible mechanism of action. Capsaicin 266-275 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 205-254 34113239-1 2021 Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor (TRPV1) in capsaicin-induced acute inflammatory pain and the possible mechanism of action. Capsaicin 266-275 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 256-261 35602097-0 2022 Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 77-82 35602097-2 2022 This study was designed to investigate whether capsaicin (CAP), a selective TRPV1 agonist, could prevent diabetes-induced endothelial dysfunction and cardiomyopathy. Capsaicin 47-56 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 76-81 35602097-2 2022 This study was designed to investigate whether capsaicin (CAP), a selective TRPV1 agonist, could prevent diabetes-induced endothelial dysfunction and cardiomyopathy. Capsaicin 58-61 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 76-81 35602097-9 2022 In addition, CAP enhanced the expression of TRPV1 and eNOS in the heart and normalized the vascular permeability under diabetic state. Capsaicin 13-16 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 44-49 35563108-7 2022 Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate. Capsaicin 15-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 159-164 23461032-5 2012 Sensitivity to capsaicin was shown in largest neurons in each population; neurons in experimental group had smaller cross-sectional area, particularly in group of TRPV1(+)-neurons. Capsaicin 15-24 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 163-168 34883200-4 2022 CIH yielded enhanced behavioral responses to capsaicin, a TRPV1 agonist, after application to the ocular surface and intraoral mucosa, which was reversed under normoxic conditions. Capsaicin 45-54 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 58-63 34331901-8 2021 Hypothermia also promoted a reduction in mRNA expression of the capsaicin receptor TRPV1 in H9c2 cells. Capsaicin 64-73 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 83-88 35370565-6 2022 Capsaicin, a specific agonist known to activated the transient receptor potential vanilloid type 1 (TRPV1), is involved in hippocampal synaptic plasticity and memory, but the detailed mechanism is still unclear. Capsaicin 0-9 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 100-105 35189809-4 2022 CGRP release was induced by either 60 mM K+ (for depolarization-induced stimulation) or 100 nM capsaicin (for transient receptor potential vanilloid 1 (TRPV1) -induced stimulation) and measured using an enzyme-linked immunosorbent assay. Capsaicin 95-104 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 152-157 35063502-9 2022 This study revealed that pentobarbital functions between the activation of vanilloid receptor subtype 1 (TRPV1) receptors, to which capsaicin selectively binds, and the opening of voltage-operated Ca2+ channels (VOCC) in the nerve endings. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 75-103 35063502-9 2022 This study revealed that pentobarbital functions between the activation of vanilloid receptor subtype 1 (TRPV1) receptors, to which capsaicin selectively binds, and the opening of voltage-operated Ca2+ channels (VOCC) in the nerve endings. Capsaicin 132-141 transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus 105-110