PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	TNF receptor superfamily member 11b	Homo sapiens	192-207	
23411401-10	2013	Phospholipase C (PLC) was previously shown to be involved in capsaicin-induced OPG expression.	Capsaicin	61-70	TNF receptor superfamily member 11b	Homo sapiens	79-82	
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	TNF receptor superfamily member 11b	Homo sapiens	209-212	
22587561-8	2013	The mechanisms of capsaicin-induced OPG expression in HPDL cells were studied using inhibitors.	Capsaicin	18-27	TNF receptor superfamily member 11b	Homo sapiens	36-39	
22587561-10	2013	Treatment with capsaicin induced OPG expression in a dose-dependent manner but did not affect the expression of RANKL.	Capsaicin	15-24	TNF receptor superfamily member 11b	Homo sapiens	33-36	
22587561-12	2013	Capsazepine, the competitive TRPV1 antagonist, significantly abolished the effect of capsaicin on OPG expression in HPDL cells.	Capsaicin	85-94	TNF receptor superfamily member 11b	Homo sapiens	98-101	
22587561-14	2013	Interestingly, capsaicin was able to increase the OPG/RANKL ratio, even in the presence of prostaglandin E2, a potent inducer of RANKL.	Capsaicin	15-24	TNF receptor superfamily member 11b	Homo sapiens	50-53