PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23411401-1 2013 OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells. Capsaicin 150-159 TNF receptor superfamily member 11b Homo sapiens 192-207 23411401-1 2013 OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells. Capsaicin 150-159 TNF receptor superfamily member 11b Homo sapiens 209-212 23411401-10 2013 Phospholipase C (PLC) was previously shown to be involved in capsaicin-induced OPG expression. Capsaicin 61-70 TNF receptor superfamily member 11b Homo sapiens 79-82 22587561-8 2013 The mechanisms of capsaicin-induced OPG expression in HPDL cells were studied using inhibitors. Capsaicin 18-27 TNF receptor superfamily member 11b Homo sapiens 36-39 22587561-10 2013 Treatment with capsaicin induced OPG expression in a dose-dependent manner but did not affect the expression of RANKL. Capsaicin 15-24 TNF receptor superfamily member 11b Homo sapiens 33-36 22587561-12 2013 Capsazepine, the competitive TRPV1 antagonist, significantly abolished the effect of capsaicin on OPG expression in HPDL cells. Capsaicin 85-94 TNF receptor superfamily member 11b Homo sapiens 98-101 22587561-14 2013 Interestingly, capsaicin was able to increase the OPG/RANKL ratio, even in the presence of prostaglandin E2, a potent inducer of RANKL. Capsaicin 15-24 TNF receptor superfamily member 11b Homo sapiens 50-53