PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30935063-2 2019 Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. Capsaicin 113-122 transient receptor potential cation channel subfamily A member 1 Homo sapiens 64-69 29746471-9 2018 Here, we show that capsaicin induces a rise in intracellular Ca2+ in mammalian cells expressing either SmTRPA or a S. haematobium TRPA1 orthologue (ShTRPA). Capsaicin 19-28 transient receptor potential cation channel subfamily A member 1 Homo sapiens 130-135 29847470-4 2018 This human experimental study investigated whether functional responses from the subpopulation of TRPA1 nociceptors could be evoked after defunctionalization of TRPV1 nociceptors by cutaneous application of high-concentration capsaicin. Capsaicin 226-235 transient receptor potential cation channel subfamily A member 1 Homo sapiens 98-103 29847470-12 2018 Ablation of cutaneous capsaicin-sensitive afferents caused consistent and equal inhibition of both TRPV1- and TRPA1-provoked responses assessed psychophysically and by imaging of vasomotor responses. Capsaicin 22-31 transient receptor potential cation channel subfamily A member 1 Homo sapiens 110-115 29847470-13 2018 This study suggests that TRPA1 nociceptive responses in human skin strongly depend on intact capsaicin-sensitive, TRPV1 fibers. Capsaicin 93-102 transient receptor potential cation channel subfamily A member 1 Homo sapiens 25-30 29596157-0 2018 Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin. Capsaicin 171-180 transient receptor potential cation channel subfamily A member 1 Homo sapiens 96-101 26859646-6 2016 RESULTS: Activation of hTRPA1 by carvacrol and hTRPV1 by capsaicin produced a QX-314-independent reduction of sodium current amplitudes. Capsaicin 57-66 transient receptor potential cation channel subfamily A member 1 Homo sapiens 23-29 28571526-3 2017 By reverse transcription polymerase chain reaction, we demonstrate that the calcium-permeable ion channels TRPA1, TRPV1, and its capsaicin-insensitive isoform TRPV1b are expressed in human gingival fibroblasts (HGFs), the most abundant cellular type in periodontal tissue. Capsaicin 129-138 transient receptor potential cation channel subfamily A member 1 Homo sapiens 107-112 27391380-6 2016 Mechanistic studies identified the ion channels TRPV1 and TRPA1 as targets of capsaicin in pepper spray, and of the tear gas agents chloroacetophenone, CS, and CR. Capsaicin 78-87 transient receptor potential cation channel subfamily A member 1 Homo sapiens 58-63 28515697-5 2017 TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively. Capsaicin 51-60 transient receptor potential cation channel subfamily A member 1 Homo sapiens 10-15 26655809-10 2015 Mammalian TRPA1 is not activated by capsaicin, yet knockdown of the single predicted TRPA1-like gene (SmTRPA) in S. mansoni effectively abolishes capsaicin-induced responses in adult worms, suggesting that SmTRPA is required for capsaicin sensitivity in these parasites. Capsaicin 146-155 transient receptor potential cation channel subfamily A member 1 Homo sapiens 85-90 26655809-10 2015 Mammalian TRPA1 is not activated by capsaicin, yet knockdown of the single predicted TRPA1-like gene (SmTRPA) in S. mansoni effectively abolishes capsaicin-induced responses in adult worms, suggesting that SmTRPA is required for capsaicin sensitivity in these parasites. Capsaicin 146-155 transient receptor potential cation channel subfamily A member 1 Homo sapiens 85-90 25666822-0 2015 Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands. Capsaicin 31-43 transient receptor potential cation channel subfamily A member 1 Homo sapiens 49-54 26054320-4 2015 Specific inhibitors of TRPA1 (HC- 030031) and a specific activator of TRPV1 (capsaicin) were used to block or activate TRPA1 and TRPV1, respectively. Capsaicin 77-86 transient receptor potential cation channel subfamily A member 1 Homo sapiens 119-124 25666822-1 2015 Replacement of the benzylamide motif of synthetic capsaicin (nonivamide, 1c) with a tetrazole moiety was detrimental for TRPV1 binding, but unexpectedly generated a potent and non-electrophilic TRPA1 agonist (4a). Capsaicin 50-59 transient receptor potential cation channel subfamily A member 1 Homo sapiens 194-199 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-45 transient receptor potential cation channel subfamily A member 1 Homo sapiens 127-132 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-45 transient receptor potential cation channel subfamily A member 1 Homo sapiens 209-214 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-42 transient receptor potential cation channel subfamily A member 1 Homo sapiens 127-132 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-42 transient receptor potential cation channel subfamily A member 1 Homo sapiens 209-214 21316356-9 2011 TRPA1 responses were mixed across neurons that were capsaicin-sensitive and -insensitive. Capsaicin 52-61 transient receptor potential cation channel subfamily A member 1 Homo sapiens 0-5 24643480-6 2014 A TRPV1::TRPA1 concatemer was responsive to TRPV1 agonists capsaicin, acidic pH and ethanol, but not to TRPA1 agonists. Capsaicin 59-68 transient receptor potential cation channel subfamily A member 1 Homo sapiens 9-14 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 75-84 transient receptor potential cation channel subfamily A member 1 Homo sapiens 38-43 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 128-137 transient receptor potential cation channel subfamily A member 1 Homo sapiens 38-43 20303522-6 2010 Capsaicin increased relaxant responses to all TRPA1 agonists. Capsaicin 0-9 transient receptor potential cation channel subfamily A member 1 Homo sapiens 46-51 21156013-7 2010 TRPV1 is co-expressed with TRPA1, and TRPA1 is known to be present on capsaicin-sensitive primary sensory neurones. Capsaicin 70-79 transient receptor potential cation channel subfamily A member 1 Homo sapiens 38-43 19491712-7 2009 TRPA1 expressed in capsaicin-sensitive and insensitive neurons. Capsaicin 19-28 transient receptor potential cation channel subfamily A member 1 Homo sapiens 0-5 19686135-4 2009 This is illustrated by the use of capsaicin, menthol, and wasabi to identify the heat-sensitive ion channel TRPV1, the cold-sensitive ion channel TRPM8, and the irritant receptor TRPA1, respectively. Capsaicin 34-43 transient receptor potential cation channel subfamily A member 1 Homo sapiens 179-184 17728277-11 2008 Capsaicin, mustard oil, and cinnamaldehyde may induce heat hyperalgesia via enhanced thermal gating of TRPV1 that is coexpressed with TRPA1 in peripheral nociceptors. Capsaicin 0-9 transient receptor potential cation channel subfamily A member 1 Homo sapiens 134-139 17584831-3 2007 Here we show that TRPA1 is desensitized by homologous (mustard oil; a TRPA1 agonist) and heterologous (capsaicin; a TRPV1 agonist) agonists via Ca2+-independent and Ca2+-dependent pathways, respectively, in sensory neurons. Capsaicin 103-112 transient receptor potential cation channel subfamily A member 1 Homo sapiens 18-23 17584831-4 2007 The pharmacological desensitization of TRPA1 by capsaicin and mustard oil is not influenced by activation of protein phosphatase 2B. Capsaicin 48-57 transient receptor potential cation channel subfamily A member 1 Homo sapiens 39-44 15283452-5 2004 TRPV1 and ANKTM1 are mediating the pungency of nociceptor-specific chemicals such as capsaicin or mustard oil. Capsaicin 85-94 transient receptor potential cation channel subfamily A member 1 Homo sapiens 10-16 12654248-7 2003 Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol. Capsaicin 114-123 transient receptor potential cation channel subfamily A member 1 Homo sapiens 34-40 35163843-6 2022 Radioactive 45Ca2+ uptake and ATP-based luminescence indicating cell viability were measured in PE/CA-PJ41 cells in response to the TRPA1 agonist allyl-isothiocyanate (AITC) and TRPV1 agonist capsaicin to determine receptor function. Capsaicin 192-201 transient receptor potential cation channel subfamily A member 1 Homo sapiens 132-137 35163843-8 2022 TRPA1 and TRPV1 activation (100 microM AITC, 100 nM capsaicin) induced 45Ca2+-influx into PE/CA-PJ41 cells. Capsaicin 52-61 transient receptor potential cation channel subfamily A member 1 Homo sapiens 0-5 32781866-6 2021 TRPA1, TRPM2 and TRPV1 of the eight groups were further stimulated by cinnamaldehyde, cumene hydyroperoxide and capsaicin, respectively although they were further inhibited by AP-18, N-(p-Amylcinnamoyl) anthranilic acid (ACA) and capsazepine (CPZ). Capsaicin 112-121 transient receptor potential cation channel subfamily A member 1 Homo sapiens 0-5