PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24686644-1 2014 A method for measuring diffuse reflectivity using cubic cavity based on the variable port fraction method was developed by measuring oxygen P11 line at 762 nm using tunable diode laser absorption spectroscopy. Oxygen 133-139 endonuclease, poly(U) specific Homo sapiens 140-143 25594427-9 2015 CT327 inhibited capsaicin responses, indicating action at the nerve growth factor-TrkA-TRPV1 pathway. Capsaicin 16-25 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 25377933-3 2015 In the model, CGRP release is provoked after dermal capsaicin application, by activating transient receptor potential vanilloid-type-1 (TRPV1) receptors at peripheral sensory nerves. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-134 25377933-3 2015 In the model, CGRP release is provoked after dermal capsaicin application, by activating transient receptor potential vanilloid-type-1 (TRPV1) receptors at peripheral sensory nerves. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 136-141 25850459-4 2015 In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 4 antagonized capsaicin-induced Ca(2+) influx, with an IC50 value of 4.6 nM. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 25666693-1 2015 INTRODUCTION: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that can be activated by noxious heat, low pH and vanilloid compounds such as capsaicin. Capsaicin 179-188 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-59 26130469-6 2015 Therapeutic effectiveness for this condition has been demonstrated through desensitization of TRPV1 channels with typical agonists such as capsaicin. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 25445434-1 2015 The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed mainly by sensory neurons that detect noxious stimuli from the environment such as high temperatures and pungent compounds (such as allicin and capsaicin) and has been extensively linked to painful and inflammatory processes. Capsaicin 222-231 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-44 25445434-1 2015 The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed mainly by sensory neurons that detect noxious stimuli from the environment such as high temperatures and pungent compounds (such as allicin and capsaicin) and has been extensively linked to painful and inflammatory processes. Capsaicin 222-231 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 25431172-4 2015 Depolarization of DRG neurons by a transient receptor potential vanilloid 1 (TRPV 1) activator, capsaicin was attenuated by E6005 as well as by a 3",5"-cyclic adenosine monophosphate (cAMP) elevator, forskolin. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-75 25431172-4 2015 Depolarization of DRG neurons by a transient receptor potential vanilloid 1 (TRPV 1) activator, capsaicin was attenuated by E6005 as well as by a 3",5"-cyclic adenosine monophosphate (cAMP) elevator, forskolin. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-83 25781982-4 2015 In addition to ASICs, capsaicin- and heat-activated transient receptor potential vanilloid 1 (TRPV1) channels can also mediate proton-mediated pain signaling. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-92 25781982-4 2015 In addition to ASICs, capsaicin- and heat-activated transient receptor potential vanilloid 1 (TRPV1) channels can also mediate proton-mediated pain signaling. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 25666822-1 2015 Replacement of the benzylamide motif of synthetic capsaicin (nonivamide, 1c) with a tetrazole moiety was detrimental for TRPV1 binding, but unexpectedly generated a potent and non-electrophilic TRPA1 agonist (4a). Capsaicin 50-59 transient receptor potential cation channel subfamily V member 1 Homo sapiens 121-126 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 117-122 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 203-208 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-42 transient receptor potential cation channel subfamily V member 1 Homo sapiens 117-122 25666822-4 2015 These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif. Capsaicin 33-42 transient receptor potential cation channel subfamily V member 1 Homo sapiens 203-208 25666878-5 2015 The neutrophils in TRPM2 and TRPV1 experiments were stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; 1 muM) and capsaicin (10 muM) as concentration agonists, respectively. Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 25814480-1 2015 The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin. Capsaicin 167-176 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-49 25814480-1 2015 The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin. Capsaicin 167-176 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 25666693-1 2015 INTRODUCTION: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that can be activated by noxious heat, low pH and vanilloid compounds such as capsaicin. Capsaicin 179-188 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 25250537-7 2015 PAO modulation of the capsaicin-activated current in hTRPV1/Chinese hamster ovary cells consisted of potentiation of the current elicited with low capsaicin concentrations and inhibition of the current at higher concentrations. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-59 25460045-6 2015 TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 138-153 25460045-6 2015 TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 155-160 25460045-6 2015 TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response. Capsaicin 76-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 138-153 25460045-6 2015 TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response. Capsaicin 76-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 155-160 25597011-2 2015 Among them, compound 15 showed highly potent TRPV1 antagonism to capsaicin, with Ki(ant)=0.2nM, as well as antagonism to other activators, and it was efficacious in a pain model. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-50 25849380-11 2015 Capsaicin increased the expression levels of p-CaM, Cx43, CaMKII, PPARdelta and HSL in mesenteric adipose tissues from WT mice fed a high-fat diet, db/db mice, as well as obese humans, but these effects of capsaicin were absent in TRPV1-/- mice. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 231-236 25670201-3 2015 This regulation could contribute to the cellular mechanisms by which the TRPV1 activator capsaicin mitigates mechanical hypersensitivity. Capsaicin 89-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 25670203-1 2015 Capsaicin is an activator of the heat-sensitive TRPV1 (transient receptor potential vanilloid 1) ion channels and has been used as a local analgesic. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-53 25670203-1 2015 Capsaicin is an activator of the heat-sensitive TRPV1 (transient receptor potential vanilloid 1) ion channels and has been used as a local analgesic. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 55-95 25670203-2 2015 We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the mechanosensitive Piezo1 and Piezo2 channels by depleting phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and its precursor phosphatidylinositol 4-phosphate [PI(4)P] from the plasma membrane through Ca(2+)-induced phospholipase Cdelta (PLCdelta) activation. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-33 26602570-8 2015 Capsaicin and its analog capsinoids, representative agonists of TRPV1, mimic the effects of cold to decrease body fatness through the activation and recruitment of BAT. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 64-69 25959004-4 2015 Local application of high concentration of capsaicin is used for neuropathic pain and repeated stimulation of TRPV-1 induced an improvement of epigastric pain in irritable bowel syndrome and dyspepsia patients by desensitization of nociceptive pathways. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-116 26411767-8 2015 Thus activation of TRPV1 by oxidative stress, resiniferatoxin, cannabinoid receptor (CB1) activators (i.e. anandamide) or capsaicin induced epileptic effects, and these effects could be reduced by appropriate inhibitors, including capsazepine (CPZ), 5"-iodoresiniferatoxin (IRTX), resolvins, and CB1 antagonists. Capsaicin 122-131 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-24 25422952-0 2015 Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 84-89 25959004-1 2015 Capsaicin, a pharmacologically active agent found in chili peppers, causes burning and itching sensation due to binding at the transient receptor potential vanilloid-1 (TRPV-1) receptor, a polymodal receptor critical to the sensing of a variety of stimuli (e.g., noxious heat, bidirectional pH), and subsequent activation of polymodal C and A-delta nociceptive fibers. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 169-175 25959004-2 2015 Acutely, TRPV-1 activation with peripheral capsaicin produces pronociceptive effects, which extends to the development of hyperalgesia and allodynia. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 9-15 25959004-3 2015 However, capsaicin has been reported to display antinociceptive properties as well, largely through TRPV-1-dependent mechanisms. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 100-106 24643480-6 2014 A TRPV1::TRPA1 concatemer was responsive to TRPV1 agonists capsaicin, acidic pH and ethanol, but not to TRPA1 agonists. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 2-7 25450464-6 2014 Furthermore, the TRPV1 agonists capsaicin and anandamide decreased cytotrophoblast viability and induced morphological alterations, such as chromatin condensation and fragmentation, which suggest the occurrence of apoptosis. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 25450464-8 2014 Furthermore, capsaicin (10 muM) impaired the spontaneous in vitro differentiation of cytotrophoblasts into syncytiotrophoblasts by triggering TRPV1, as observed by the decrease in placental alkaline phosphatase activity and in human chorionic gonadotropin secretion. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 142-147 25277470-1 2015 OBJECTIVE: Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Adelta fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-155 25277470-1 2015 OBJECTIVE: Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Adelta fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 157-162 24326980-2 2014 In an earlier study, we found that stimulation of pharyngeal sensory neurons by capsaicinoids acting on transient receptor potential vanilloid 1 (TRPV1) improved the swallow response of dysphagic patients. Capsaicin 80-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 104-144 24326980-2 2014 In an earlier study, we found that stimulation of pharyngeal sensory neurons by capsaicinoids acting on transient receptor potential vanilloid 1 (TRPV1) improved the swallow response of dysphagic patients. Capsaicin 80-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 146-151 25029033-7 2014 The prototypical TRPV1 agonist, capsaicin, produced similar, although not identical effects. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 25029033-8 2014 Capsaicin, but not CBDV, effects on burst amplitude were reversed by IRTX, a selective TRPV1 antagonist. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 25029033-10 2014 However, TRPV1 was strongly phosphorylated (and hence likely sensitized) in Mg(2+)-free solution-treated hippocampal tissue, and both capsaicin and CBDV caused TRPV1 dephosphorylation, consistent with TRPV1 desensitization. Capsaicin 134-143 transient receptor potential cation channel subfamily V member 1 Homo sapiens 160-165 25029033-10 2014 However, TRPV1 was strongly phosphorylated (and hence likely sensitized) in Mg(2+)-free solution-treated hippocampal tissue, and both capsaicin and CBDV caused TRPV1 dephosphorylation, consistent with TRPV1 desensitization. Capsaicin 134-143 transient receptor potential cation channel subfamily V member 1 Homo sapiens 160-165 24643480-6 2014 A TRPV1::TRPA1 concatemer was responsive to TRPV1 agonists capsaicin, acidic pH and ethanol, but not to TRPA1 agonists. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 44-49 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 185-190 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 185-190 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 185-190 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 185-190 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 185-190 24643480-12 2014 However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 185-190 25254316-5 2014 Using this approach, we pinpointed regions of TRPV1 that affect channel properties upon their removal, causing changes in current amplitude, single-channel conductance, and EC50 value toward its agonist, capsaicin. Capsaicin 204-213 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 24887171-2 2014 Although first studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 has been recently recognized to have a broader distribution in the central nervous system, where it is likely to constitute an atypical neurotransmission system involved in several functions through modulation of both neuronal and glial activities. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 81-86 25062738-11 2014 In contrast, exposure to the TRPV1 agonist capsaicin or the TRPM8 agonist icilin had no effect on intracellular Ca(2+) concentration. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 25263209-6 2014 Capsaicin, a TRPV1 agonist increased the frequency of miniature EPSCs in 50% of LepRb(EGFP) neurons without altering the frequency of miniature IPSCs in the DMV. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 24966300-4 2014 The nicotinic ACh receptors (nAChRs) appear to be expressed by some group III-IV neurons since capsaicin (TRPV1) and/or ATP (P2X) induced current in 56% of ACh-responsive neurons. Capsaicin 95-104 transient receptor potential cation channel subfamily V member 1 Homo sapiens 106-111 25222270-1 2014 Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 25222270-1 2014 Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 24666696-1 2014 BACKGROUND: Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both animals and human subjects through activation of transient receptor potential vanilloid 1 (TRPV1) on airway sensory nerves. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 145-185 24878626-5 2014 Capsaicin is a known agonist of the TRPV1 receptor. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-41 24878626-6 2014 We observed that capsaicin-induced apoptosis in human SCLC cells was mediated via the TRPV receptor family; however it was independent of TRPV1. Capsaicin 17-26 transient receptor potential cation channel subfamily V member 1 Homo sapiens 138-143 24889371-4 2014 The TRPV1 level was a determinant of cell death induced by capsaicin. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 24889371-5 2014 A concentration response curve with varying TRPV1 expression levels identified the minimum level of TRPV1 required for capsaicin induced cell death. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 44-49 24889371-5 2014 A concentration response curve with varying TRPV1 expression levels identified the minimum level of TRPV1 required for capsaicin induced cell death. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 100-105 24666696-1 2014 BACKGROUND: Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both animals and human subjects through activation of transient receptor potential vanilloid 1 (TRPV1) on airway sensory nerves. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 187-192 24139494-0 2014 Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 123-128 24675661-7 2014 The activation of TRPV1 by voltage or ligands (capsaicin and 2-aminoethoxydiphenyl borate) is also potentiated by nicotinic acid. Capsaicin 47-56 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-23 24391116-2 2014 Applied on the skin, capsaicin activates the transient receptor potential vanilloid type 1 (TRPV1) channel and releases CGRP from sensory nerve terminals, thus increasing dermal blood flow (DBF). Capsaicin 21-30 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-90 24391116-2 2014 Applied on the skin, capsaicin activates the transient receptor potential vanilloid type 1 (TRPV1) channel and releases CGRP from sensory nerve terminals, thus increasing dermal blood flow (DBF). Capsaicin 21-30 transient receptor potential cation channel subfamily V member 1 Homo sapiens 92-97 23902373-7 2014 Like other TRPV1 agonists, several synthetic analogues could efficiently desensitize TRPV1 to activation by capsaicin. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 11-16 23902373-7 2014 Like other TRPV1 agonists, several synthetic analogues could efficiently desensitize TRPV1 to activation by capsaicin. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 85-90 23909699-0 2014 Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 24861977-1 2014 Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids. Capsaicin 131-140 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 24861977-1 2014 Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids. Capsaicin 131-140 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 24599956-3 2014 We observed potentiation of capsaicin-activated TRPV1 currents by PI(4,5)P2 in the intracellular leaflet of the plasma membrane but inhibition of capsaicin-activated currents when PI(4,5)P2 was in both leaflets of the membrane, although much higher concentrations of PI(4,5)P2 in the extracellular leaflet were required for inhibition compared with the concentrations of PI(4,5)P2 in the intracellular leaflet that produced activation. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-53 24743737-4 2014 Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway. Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 149-154 24743737-4 2014 Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway. Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 273-278 24743737-4 2014 Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway. Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 273-278 24743737-4 2014 Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway. Capsaicin 282-291 transient receptor potential cation channel subfamily V member 1 Homo sapiens 149-154 24743737-4 2014 Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway. Capsaicin 282-291 transient receptor potential cation channel subfamily V member 1 Homo sapiens 149-154 24139494-10 2014 Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment. Capsaicin 153-162 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 24139494-13 2014 Capsaicin exerts its therapeutic action by ablating the TRPV1-SP nociceptive signaling pathway in the nasal mucosa. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 24695785-1 2014 The transient receptor potential family V1 channel (TRPV1) is activated by multiple stimuli, including capsaicin, acid, endovanilloids, and heat (>42C). Capsaicin 103-112 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 24495556-5 2014 TRPV1 agonist is capsaicine (1). Capsaicin 17-27 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 24495935-0 2014 Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 81-86 24705155-2 2014 Given that cigarette smoking triggers proinflammatory response via stimulation of the capsaicin-sensitive transient receptor potential cation channel TRPV1, this study was designed to evaluate the effect of an essential alpha,beta-unsaturated aldehyde from cigarette smoke crotonaldehyde on myocardial function and the underlying mechanism with a focus on TRPV1 and mitochondria. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 150-155 24308840-7 2014 Mutations disrupting the capsaicin-binding site attenuated LE135 activation of TRPV1 channels and a single mutation (K170R) eliminated TRPA1 activity evoked by LE135. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 79-84 24462040-1 2014 The peripheral terminals of primary nociceptive neurons play an essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and capsaicin. Capsaicin 171-180 transient receptor potential cation channel subfamily V member 1 Homo sapiens 133-138 24210884-11 2014 In functional assays the TRPV1 agonist capsaicin induced dose-dependent IL-8 release, which could be blocked by the antagonist capsazepine. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-30 25170901-4 2014 RESULTS: TRPV1 activation by capsaicin (CAP) and an increase in osmolarity to 450 mOsM both induced increases in Ca(2+) levels. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 9-14 24688365-9 2014 CONCLUSION: TRPV1 receptor is successfully stimulated by capsaicin, piperine, and natural capsaicinoids. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 24688365-9 2014 CONCLUSION: TRPV1 receptor is successfully stimulated by capsaicin, piperine, and natural capsaicinoids. Capsaicin 90-103 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 24275229-1 2014 Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and chemicals such as capsaicin. Capsaicin 154-163 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 24275229-1 2014 Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and chemicals such as capsaicin. Capsaicin 154-163 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 24075930-1 2014 Capsaicin (CAP), the pungent ingredient of chili peppers, inhibits growth of various solid cancers via TRPV1 as well as TRPV1-independent mechanisms. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 24075930-1 2014 Capsaicin (CAP), the pungent ingredient of chili peppers, inhibits growth of various solid cancers via TRPV1 as well as TRPV1-independent mechanisms. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 120-125 23886380-6 2014 The administration of capsaicin as an agonist stimulus of TRPV1, a warm temperature receptor, decreased the delay in swallowing reflex. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 24830013-14 2014 While receptors have been discovered for several individual chemicals:one example is the TrpV1 channel for the neurotoxin capsaicin:other mechanisms must be discovered to account for the effects of most painful and itchy substances. Capsaicin 122-131 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 24299199-2 2014 Our objective was to use the epidermis as a relay for the induction of an electric current to the neurons following the topical application of capsaicin on the skin epidermis of the skin explant, an agonist of the TRPV1 channel implicated in pruritus and pain. Capsaicin 143-152 transient receptor potential cation channel subfamily V member 1 Homo sapiens 214-219 24961971-6 2014 TRPV1 is a receptor for pungent chemical stimuli such as capsaicin and for several irritants (chemesthesis). Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 24961985-5 2014 was isolated in 1846 and the receptor for the biological actions of capsaicin was cloned in 1997, which is now known as TRPV1 (transient receptor potential vanilloid 1). Capsaicin 68-77 transient receptor potential cation channel subfamily V member 1 Homo sapiens 120-125 24961985-5 2014 was isolated in 1846 and the receptor for the biological actions of capsaicin was cloned in 1997, which is now known as TRPV1 (transient receptor potential vanilloid 1). Capsaicin 68-77 transient receptor potential cation channel subfamily V member 1 Homo sapiens 127-167 25629137-4 2014 Capsaicin, a component of chili pepper and several other plants, is a highly selective ligand of TRPV1 receptors and has long been used in treatment of pain syndromes. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-102 24941663-8 2014 Neurogenic inflammation and the long-list of "capsaicin-sensitive" tissue responses are mediated by an unorthodox dual sensory-efferent function of peptidergic TRPV1-expressing nerve terminals which differ from the classical efferent and sensory nerve endings that have a unidirectional role in neuroregulation. Capsaicin 46-55 transient receptor potential cation channel subfamily V member 1 Homo sapiens 160-165 24941664-1 2014 The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (> -42 degrees C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 83-88 24941667-3 2014 Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and even, in sufficient dosing, to create long-term nerve terminal defunctionalization. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 24941667-3 2014 Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and even, in sufficient dosing, to create long-term nerve terminal defunctionalization. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 106-111 24941668-1 2014 Capsaicin is a selective transient receptor potential vanilloid 1 (TRPV1) ion channel agonist and has been demonstrated to reduce nerve conduction of nociceptive C fibers in the trigeminal nerve without affecting conduction in Adelta fibers. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-65 24941668-1 2014 Capsaicin is a selective transient receptor potential vanilloid 1 (TRPV1) ion channel agonist and has been demonstrated to reduce nerve conduction of nociceptive C fibers in the trigeminal nerve without affecting conduction in Adelta fibers. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 24941668-5 2014 Rational approaches to treat the pathophysiology of NAR would be to develop therapies with selective TRPV1 agonist activity like capsaicin that target desensitization of TRP ion channels on sensory afferent nerves. Capsaicin 129-138 transient receptor potential cation channel subfamily V member 1 Homo sapiens 101-106 24174527-0 2013 Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization. Capsaicin 123-132 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-68 24351908-6 2013 In the electrophysiological study, both polypeptides partially blocked the capsaicin-induced response of TRPV1, but only APHC3 inhibited acid-induced (pH 5.5) activation of the receptor. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 105-110 24174527-1 2013 Multiple Ca(2+)-dependent processes are involved in capsaicin-induced desensitization of transient receptor potential vanilloid 1 (TRPV1), but desensitization of TRPV1 by heat occurs even in the absence of extracellular Ca(2+), although the mechanisms are unknown. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-129 24174527-1 2013 Multiple Ca(2+)-dependent processes are involved in capsaicin-induced desensitization of transient receptor potential vanilloid 1 (TRPV1), but desensitization of TRPV1 by heat occurs even in the absence of extracellular Ca(2+), although the mechanisms are unknown. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 131-136 24174527-2 2013 In this study, we tested the hypothesis that capsaicin and heat desensitize TRPV1 through distinct mechanisms involving distinct structural segments of TRPV1. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 24174527-2 2013 In this study, we tested the hypothesis that capsaicin and heat desensitize TRPV1 through distinct mechanisms involving distinct structural segments of TRPV1. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 152-157 24174527-8 2013 The results suggest that the activation and desensitization of TRPV1 by capsaicin and heat can be modulated differentially and disproportionally through different regions of TRPV1 CTD. Capsaicin 72-81 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 24174527-8 2013 The results suggest that the activation and desensitization of TRPV1 by capsaicin and heat can be modulated differentially and disproportionally through different regions of TRPV1 CTD. Capsaicin 72-81 transient receptor potential cation channel subfamily V member 1 Homo sapiens 174-179 23719767-6 2013 METHODS: To evaluate the mechanism of the antinociceptive effects of KMS4034, capsaicin (I(CAP))- and heat (I(heat))-induced currents in TRPV1 expressing HEK293 cells were observed after the application of KMS4034. Capsaicin 78-87 transient receptor potential cation channel subfamily V member 1 Homo sapiens 137-142 24158445-1 2013 The regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channels by phosphoinositides is controversial. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-92 24158445-1 2013 The regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channels by phosphoinositides is controversial. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 24158445-5 2013 When we incorporated TRPV1 into planar lipid bilayers consisting of neutral lipids, capsaicin-induced activity depended on phosphatidylinositol 4,5-bisphosphate. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 21-26 24211679-2 2013 Understanding the actions of capsaicin led to the discovery of its receptor, transient receptor potential vanilloid subfamily member 1 (TRPV1). Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 136-141 23942896-8 2013 Perfusion of the entire submandibular gland with the TRPV1 agonist capsaicin (1 muM) via the submandibular artery significantly increased CCh-induced salivation, whereas perfusion with TRPM8 and TRPA1 agonists (0.5 muM WS12 and 100 muM allyl isothiocyanate) decreased it. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 23929722-2 2013 Binding of capsaicin to the vanilloid receptor 1 (transient receptor potential cation channel subfamily V member 1 (TRPV1)) is one of the major cellular mechanisms responsible for these effects. Capsaicin 11-20 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-114 23929722-2 2013 Binding of capsaicin to the vanilloid receptor 1 (transient receptor potential cation channel subfamily V member 1 (TRPV1)) is one of the major cellular mechanisms responsible for these effects. Capsaicin 11-20 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-121 23929722-3 2013 However, strong TRPV1 agonists like capsaicin elicit a sharp, burning pain that limits their dietary intake. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-21 23929722-7 2013 Co-incubation experiments of SH-SY5Y cells with the TRPV1 inhibitors trans-tert-butylcyclohexanol and capsazepine demonstrated that capsaicin, but not nonivamide, induces serotonin and dopamine release through TRPV1 activation. Capsaicin 132-141 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 23929722-7 2013 Co-incubation experiments of SH-SY5Y cells with the TRPV1 inhibitors trans-tert-butylcyclohexanol and capsazepine demonstrated that capsaicin, but not nonivamide, induces serotonin and dopamine release through TRPV1 activation. Capsaicin 132-141 transient receptor potential cation channel subfamily V member 1 Homo sapiens 210-215 23929722-8 2013 CONCLUSION: The results indicate a TRPV1-independent signaling pathway for nonivamide that might allow dietary administration of higher doses of nonivamide compared to capsaicin. Capsaicin 168-177 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-40 24004146-5 2013 We then developed a setup for rapid and quantitative delivery to multiple subcellular areas, delivering the molecule capsaicin to stimulate opening of Transient Receptor Potential Vanilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sensation. Capsaicin 117-126 transient receptor potential cation channel subfamily V member 1 Homo sapiens 210-215 23524012-6 2013 There is also some evidence that as a result of inflammation in the airways, Adelta fibres can begin to express neuropeptides and TRPV1 receptors so that they can become responsive to endogenous activators of this ion channel and to irritants like capsaicin. Capsaicin 248-257 transient receptor potential cation channel subfamily V member 1 Homo sapiens 130-135 23733747-3 2013 In this study, we used the transient receptor potential vanilloid receptor (TRPV1) receptor agonist, capsaicin, as an intranasal challenge while comparing the changes in blood flow with optical rhinometry between subjects with NAIR and healthy controls (HCs). Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 23811042-3 2013 Many nociceptors express transient receptor potential V1 (TRPV1) channels, and in a preceding study most dissociated DRG neurons exhibiting SA were excited by the TRPV1 activator, capsaicin. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-56 23811042-3 2013 Many nociceptors express transient receptor potential V1 (TRPV1) channels, and in a preceding study most dissociated DRG neurons exhibiting SA were excited by the TRPV1 activator, capsaicin. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 23811042-3 2013 Many nociceptors express transient receptor potential V1 (TRPV1) channels, and in a preceding study most dissociated DRG neurons exhibiting SA were excited by the TRPV1 activator, capsaicin. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 163-168 23811042-7 2013 Similar reversal of behavioral hypersensitivity was induced by intrathecal oligodeoxynucleotides antisense to TRPV1, which knocked down TRPV1 protein and reduced capsaicin-evoked currents. Capsaicin 162-171 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 23500195-4 2013 TRPV1 desensitization by topical agonists (e.g. high concentration capsaicin creams and patches) has been in clinical use for decades to alleviate chronic painful conditions like diabetic neuropathy. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 23850608-5 2013 TRPV1-mediated currents were measured in acutely isolated primary sensory neurons with the whole-cell patch clamp technique using capsaicin (100 nM) as the agonist. Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 23850608-7 2013 NGF sensitized TRPV1 in 31.0% of cells (13 of 42), with a mean (+-SE) increase in the capsaicin-induced current of 262 +- 47% over the baseline current. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 24044034-2 2013 The aims of this study were to investigate 1) if cutaneous sensitization by topical application of capsaicin (TRPV1 receptor agonist) can facilitate the size, duration and spatial extent of this vasomotor response and 2) if males and females respond differently. Capsaicin 99-108 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 22722616-6 2013 CONCLUSION: Stimulation of TRPV1 by capsaicinoids strongly improved safety and efficacy of swallow and shortened the swallow response in older patients with OD. Capsaicin 36-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 23916247-5 2013 This review will summarize the current knowledge on regulation of TRP channels by PLC, with special focus on TRPC-s, which can be considered as effectors of PLC and the heat- and capsaicin-sensitive TRPV1, which is modulated by the PLC pathway in a complex manner. Capsaicin 179-188 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 23757176-4 2013 Here we show that, surprisingly, AITC-induced activation of TRPV1 does not require interaction with cysteine residues, but is largely dependent on S513, a residue that is involved in capsaicin binding. Capsaicin 183-192 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-65 23605066-4 2013 The results showed that TRPV1 activation by capsaicin reduced free fatty acids (FFAs) induced the intracellular lipid droplets in HepG2 cells and prevented fatty liver in vivo. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 23796768-0 2013 Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 142-182 23796768-0 2013 Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 184-189 23859514-4 2013 Patch and cream containing capsaicin, the most famous TRPV1 agonist, are commercialized to relieve neuropathic pain. Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 54-59 23551064-1 2013 BACKGROUND: Reversible defunctionalisation of nociceptors by the TRPV1 agonist capsaicin in high concentration is an emerging new concept for the treatment of peripheral neuropathic pain. Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 65-70 23411401-1 2013 OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells. Capsaicin 150-159 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-101 23411401-1 2013 OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells. Capsaicin 150-159 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 23421411-1 2013 INTRODUCTION: The selective excitatory action of capsaicin followed by long-term chemoanalgesia due to an action on the "capsaicin receptor" of C-polymodal nociceptors, cloned 15 years ago, opened up fascinating perspectives for a class of nociceptor blocking analgesics. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 121-139 23499799-1 2013 Capsaicin, the pungent component of chilli pepper, stimulates TRPV1-expressing cells which are followed by desensitisation to subsequent exposure to capsaicin and other TRPV1 activators. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-67 23499799-1 2013 Capsaicin, the pungent component of chilli pepper, stimulates TRPV1-expressing cells which are followed by desensitisation to subsequent exposure to capsaicin and other TRPV1 activators. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 169-174 23324998-4 2013 Intravitreal injections of the classical TRPV1 agonist capsaicin up-regulated the protein expression of the inducible and endothelial NOS isoforms. Capsaicin 55-64 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 23574808-1 2013 BACKGROUND: Nasal insufflation of CO2 has been shown to exert antinociceptive respectively antihyperalgesic effects in animal pain models using topical capsaicin with activation of TRPV1-receptor positive nociceptive neurons. Capsaicin 152-161 transient receptor potential cation channel subfamily V member 1 Homo sapiens 181-186 23584166-0 2013 Capsaicin mimics mechanical load-induced intracellular signaling events: involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 23584166-4 2013 Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3beta. Capsaicin 55-64 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 23332888-5 2013 Indeed, beneficial effects of dietary capsaicin, an agonist of TRPV1 receptors, were identified for improving glucose, insulin and glucagon-like peptide-1 levels. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 23398938-7 2013 Opioid withdrawal significantly increased cAMP levels and capsaicin-induced TRPV1 activity in both transfected human embryonic kidney 293 cells and dissociated dorsal root ganglion (DRG) neurons. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 23398938-2 2013 The transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated ion channel expressed on sensory neurons responding to noxious heat, protons, and chemical stimuli such as capsaicin. Capsaicin 178-187 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-44 23398938-2 2013 The transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated ion channel expressed on sensory neurons responding to noxious heat, protons, and chemical stimuli such as capsaicin. Capsaicin 178-187 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 23470198-6 2013 Additionally, complex I also inhibited transient receptor potential cation channel subfamily V member 1 (TRPV1)-dependent overt pain-like behavior induced by capsaicin. Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 105-110 22647236-2 2013 Transient receptor potential vanilloid receptor 1 (TRPV1), a member of the transient receptor potential family, is the capsaicin receptor and is known to be involved in peripheral nociception. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-49 23220012-1 2013 The vanilloid transient receptor potential channel TRPV1 is a molecular integrator of noxious stimuli, including capsaicin, heat and protons. Capsaicin 113-122 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 23352977-1 2013 AIMS: Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 44-84 23352977-1 2013 AIMS: Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 86-91 22647236-2 2013 Transient receptor potential vanilloid receptor 1 (TRPV1), a member of the transient receptor potential family, is the capsaicin receptor and is known to be involved in peripheral nociception. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 23274405-4 2013 RECENT FINDINGS: TRPV1 may be activated by exogenous vanilloid or endo-vanilloid compounds and its function modulated by vasoactive mediators. Capsaicin 53-62 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 23274405-4 2013 RECENT FINDINGS: TRPV1 may be activated by exogenous vanilloid or endo-vanilloid compounds and its function modulated by vasoactive mediators. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 23439120-2 2013 Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, and, notably, heat, demonstrating intrinsic sensitivity of the channel to both chemical and thermal stimuli. Capsaicin 94-103 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 23171089-3 2013 Transient receptor potential vanilloid-1 (TRPV(1)) pathways are involved in gastric mechanosensory physiology and the TRPV(1) receptor agonist, capsaicin, has been used as a chemical stimulant. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 23171089-3 2013 Transient receptor potential vanilloid-1 (TRPV(1)) pathways are involved in gastric mechanosensory physiology and the TRPV(1) receptor agonist, capsaicin, has been used as a chemical stimulant. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-49 23171089-3 2013 Transient receptor potential vanilloid-1 (TRPV(1)) pathways are involved in gastric mechanosensory physiology and the TRPV(1) receptor agonist, capsaicin, has been used as a chemical stimulant. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-125 22587561-5 2013 The function of TRPV1 was studied using capsaicin, a well-known TRPV1 agonist. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-21 23264624-6 2013 The anchoring of AC to this complex generates local pools of cAMP, shifting the concentration of forskolin required to attenuate capsaicin-dependent TRPV1 desensitization by ~100-fold. Capsaicin 129-138 transient receptor potential cation channel subfamily V member 1 Homo sapiens 149-154 22918689-5 2013 So far, multiple TRPV1 agonists, including capsaicin, capsiate, anandamide and rutaecarpine are reported to exert beneficial effects on gastric mucosal injury induced by various stimuli. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 23232207-6 2013 Single-cell fluorescence imaging detected in fura2-AM loaded cells Ca(2+) transients that rose 1.8-fold above the baseline induced by a selective TRPV1 agonist, capsaicin (CAP), which were blocked by a TRPV1 antagonist, capsazepine (CPZ) or exposure to a Ca(2+) free medium. Capsaicin 161-170 transient receptor potential cation channel subfamily V member 1 Homo sapiens 146-151 23232207-6 2013 Single-cell fluorescence imaging detected in fura2-AM loaded cells Ca(2+) transients that rose 1.8-fold above the baseline induced by a selective TRPV1 agonist, capsaicin (CAP), which were blocked by a TRPV1 antagonist, capsazepine (CPZ) or exposure to a Ca(2+) free medium. Capsaicin 161-170 transient receptor potential cation channel subfamily V member 1 Homo sapiens 202-207 23139219-4 2013 Capsaicin is known to activate the transient receptor potential vanilloid type 1 (TRPV1), expressed in the mesenteric nervous system. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-80 23139219-4 2013 Capsaicin is known to activate the transient receptor potential vanilloid type 1 (TRPV1), expressed in the mesenteric nervous system. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 23413875-5 2013 Instead, pinosylvin methyl ether (PME), another derivate of stilbene which has a similar structure to resveratrol, dose-dependently blocked the capsaicin-induced currents (I CAP) in HEK293 cells that express TRPV1 as well as in DRG neurons. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 208-213 23062150-7 2013 We also show that the pharmacological profile of diverse TRPV1 antagonists is dependent on whether the stimulus is PDBu or capsaicin. Capsaicin 123-132 transient receptor potential cation channel subfamily V member 1 Homo sapiens 57-62 22691178-3 2013 Muscarinic and TRPV1 function was assessed by acetylcholine (5 mum) or capsaicin (0.5 mum) evoked ATP release, measured by luciferase assay. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 22691178-8 2013 The increase in capsaicin sensitivity correlated with increased urothelial TRPV1 expression. Capsaicin 16-25 transient receptor potential cation channel subfamily V member 1 Homo sapiens 75-80 22587561-12 2013 Capsazepine, the competitive TRPV1 antagonist, significantly abolished the effect of capsaicin on OPG expression in HPDL cells. Capsaicin 85-94 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 23956783-8 2013 Expression of TRPV1 in HuH-7 cells was confirmed by mRNA analysis as well as a test for increase of [Ca(2+)] i by TRPV1 agonist capsaicin and its inhibition by capsazepine. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 26752851-3 2013 Within the context of our hypothesis visceral nociception and nociceptor sensitization appear to be regulated by purinergic P2X3 and vanilloid TRPV1 receptors and 17beta-estradiol modulates DRG neuron response to ATP (P2X agonist) and capsaicin (TRPV1 agonist) suggesting that visceral afferent nociceptors are modulated by estrogen in the DRG. Capsaicin 235-244 transient receptor potential cation channel subfamily V member 1 Homo sapiens 143-148 23956783-8 2013 Expression of TRPV1 in HuH-7 cells was confirmed by mRNA analysis as well as a test for increase of [Ca(2+)] i by TRPV1 agonist capsaicin and its inhibition by capsazepine. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 114-119 23202294-8 2013 Notably, administration of the TRPV1 agonist capsaicin induced hypertrophy without overload and alleviated unloading- or denervation-induced atrophy. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 24260973-4 2013 Challenge with inhaled capsaicin, an exogenous agonist of TRPV1, has been used to measure the sensitivity of the cough reflex. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 22935106-3 2013 Firstly, using Western blot analysis we found that epidermal growth factor receptor (EGFR) and TRPV1 were highly co-expressed in human bronchial epithelial cells (HBE16) with HNE and capsaicin co-treated, the levels of pro-inflammatory cytokines and MUC5AC were also highly co-expressed; however, TRPV1 receptor expression was low in these cells with only HNE stimulation, which demonstrated that sensitization of TRPV1 was not increased in HBE16 cells treated with HNE alone. Capsaicin 183-192 transient receptor potential cation channel subfamily V member 1 Homo sapiens 95-100 22762936-8 2012 Capsaicin, an agonist for the transient receptor potential cation channel subfamily V member 1 (TRPV1) warm-sensing channels, partially reversed this effect in 5 subjects. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-94 23468922-4 2013 We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 84-89 23468922-4 2013 We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 236-241 22762936-8 2012 Capsaicin, an agonist for the transient receptor potential cation channel subfamily V member 1 (TRPV1) warm-sensing channels, partially reversed this effect in 5 subjects. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-101 22790593-8 2012 In HET-1A cells, the TRPV1 agonist capsaicin reproduced these findings for mRNA of the inflammatory mediators lyso-PAF AT, IL-8, and eotaxin-1. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 21-26 22820944-9 2012 In peripheral sensory neurons high concentrations of pitolisant (30-500 muM), but not ciproxifan, partially inhibited calcium increases induced by capsaicin, a selective activator of transient receptor potential vanilloid receptor 1 (TRPV1). Capsaicin 147-156 transient receptor potential cation channel subfamily V member 1 Homo sapiens 183-232 22820944-9 2012 In peripheral sensory neurons high concentrations of pitolisant (30-500 muM), but not ciproxifan, partially inhibited calcium increases induced by capsaicin, a selective activator of transient receptor potential vanilloid receptor 1 (TRPV1). Capsaicin 147-156 transient receptor potential cation channel subfamily V member 1 Homo sapiens 234-239 23109716-11 2012 In electrophysiology studies, mutation of the Ca(2+)-CaM-binding site on TRPV1-ARD abolished desensitization in response to repeated application of capsaicin, whereas mutation of the Ca(2+)-CaM-binding site in TRPV1-CT led to a more subtle phenotype of slowed and reduced TRPV1 desensitization. Capsaicin 148-157 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 22902197-2 2012 TRPV1 channels located on peripheral neurons mainly transduce the sense of heat and are also activated by low pH or capsaicin. Capsaicin 116-125 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 22819536-8 2012 CGRP release was then stimulated with the TRPV1 agonist capsaicin 1mumol/L and quantitated by enzyme immunoassay. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 23023032-2 2012 Understanding the actions of capsaicin led to the discovery its receptor, transient receptor potential (TRP) vanilloid subfamily member 1 (TRPV1), part of the superfamily of TRP receptors, sensing external events. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 139-144 22562048-4 2012 Here, we stimulated TRPV1 in the trigeminal afferents by a repetitive injection of 10 mmol/l capsaicin into the whisker pad for 2 days (d2 group), 4 days (d4 group), or 6 days (d6 group). Capsaicin 93-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 22588258-4 2012 JTS-653 competitively antagonized the capsaicin-induced activation of human TRPV1 with pA(2) values of 10.1. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 23240446-5 2012 Modulation of the activity of these fibers and/or TRPV1 receptors by a number of substances (such as capsaicin, lidocaine, etc.) Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 22570472-3 2012 We report that TRPV1 is N-glycosylated and that N-glycosylation is a major determinant of capsaicin-evoked desensitization and ionic permeability. Capsaicin 90-99 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 22570472-7 2012 Capsaicin-evoked increases in intracellular calcium ([Ca(2+)](i)) were sustained in wild-type TRPV1 HEK-293 cells but were rapidly desensitized in N604T TRPV1 cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 22570472-7 2012 Capsaicin-evoked increases in intracellular calcium ([Ca(2+)](i)) were sustained in wild-type TRPV1 HEK-293 cells but were rapidly desensitized in N604T TRPV1 cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 153-158 22570472-10 2012 Capsaicin evoked a marked, concentration-dependent increase in uptake of the large cationic dye YO-PRO-1 in cells expressing wild-type TRPV1, indicative of loss of ion selectivity, that was completely absent in cells expressing N604T TRPV1. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 135-140 22570472-10 2012 Capsaicin evoked a marked, concentration-dependent increase in uptake of the large cationic dye YO-PRO-1 in cells expressing wild-type TRPV1, indicative of loss of ion selectivity, that was completely absent in cells expressing N604T TRPV1. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 234-239 22570472-11 2012 Thus, TRPV1 is variably N-glycosylated and glycosylation is a key determinant of capsaicin regulation of TRPV1 desensitization and permeability. Capsaicin 81-90 transient receptor potential cation channel subfamily V member 1 Homo sapiens 6-11 22570472-11 2012 Thus, TRPV1 is variably N-glycosylated and glycosylation is a key determinant of capsaicin regulation of TRPV1 desensitization and permeability. Capsaicin 81-90 transient receptor potential cation channel subfamily V member 1 Homo sapiens 105-110 22929055-5 2012 Interestingly, the bladder"s sensitivity to noxious chemicals has been used successfully in clinical practice, by intravesically infusing the TRPV1 agonist capsaicin to treat neurogenic bladder overactivity. Capsaicin 156-165 transient receptor potential cation channel subfamily V member 1 Homo sapiens 142-147 22566669-4 2012 BCTP is a classic polymodal inhibitor of TRPV1, blocking activation of the human channel by capsaicin and low pH with IC(50) values of 65.4 and 26.4 nM, respectively. Capsaicin 92-101 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 22327830-9 2012 Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM). Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 22327830-9 2012 Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM). Capsaicin 37-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 22493457-1 2012 TRPV1 receptor agonists such as the vanilloid capsaicin and the potent analog resiniferatoxin are well known potent analgesics. Capsaicin 46-55 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 22184123-5 2012 In this study, we examined the behavior of heteromeric TRPV1/TRPV3 channels activated by heat, capsaicin, and voltage. Capsaicin 95-104 transient receptor potential cation channel subfamily V member 1 Homo sapiens 55-60 22516465-3 2012 On the average, capsaicin increased cAMP, cGMP concentration and SP release in bell-shaped concentration-dependent manner, with the maximal responses at concentrations around 1 muM, suggesting acute desensitization of TRPV1 receptor activation. Capsaicin 16-25 transient receptor potential cation channel subfamily V member 1 Homo sapiens 218-223 21956871-7 2012 Treating submandibular gland tissues with capsaicin, an agonist of TRPV1, substantially increased the phosphorylation of the 20-kDa regulatory light-chain subunit of myosin (MLC(20) ), a crucial molecule for contraction of smooth muscle cells, in MECs. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 21956871-8 2012 Pretreatment with capsazepine, a specific TRPV1 inhibitor, blocked capsaicin-induced MLC(20) phosphorylation. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 22314297-1 2012 BACKGROUND: The recent discovery that camphor activates and strongly desensitizes the capsaicin-sensitive and noxious heat-sensitive channel transient receptor potential vanilloid subfamily member 1 (TRPV1) has provided new insights and opened up new research paths toward understanding why this naturally occurring monoterpene is widely used in human medicine for its local counter-irritant, antipruritic, and anesthetic properties. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 200-205 22688302-1 2012 Transient receptor potential vanilloid subfamily member 1 (TRPV1) is activated by capsaicin, acid, and heat and mediates pain through peripheral nerves. Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 59-64 22420714-6 2012 We found that capsaicin and its analogs, which are TRPV1 agonists, inhibited the response to acid stimuli and that the capsaicin inhibition was reversible with an IC(50) of 32.5 mum. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 22420714-6 2012 We found that capsaicin and its analogs, which are TRPV1 agonists, inhibited the response to acid stimuli and that the capsaicin inhibition was reversible with an IC(50) of 32.5 mum. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 22289052-10 2012 Capsaicin, a TRPV1 agonist, produced depolarization and repetitive action potential firing in current clamp recordings, and large inward currents in voltage clamp recordings from acutely dissociated TG neurons, demonstrating that TRPV1 channels are functional in trigeminal neurons. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 22289052-10 2012 Capsaicin, a TRPV1 agonist, produced depolarization and repetitive action potential firing in current clamp recordings, and large inward currents in voltage clamp recordings from acutely dissociated TG neurons, demonstrating that TRPV1 channels are functional in trigeminal neurons. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 230-235 22566028-5 2012 TRPV1 agonist capsaicin mediated a concentration-dependent increase in TRPV1 inward currents and MUC5AC secretion. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 22566028-5 2012 TRPV1 agonist capsaicin mediated a concentration-dependent increase in TRPV1 inward currents and MUC5AC secretion. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 71-76 22566028-6 2012 Furthermore, capsaicin enhanced acid-induced TRPV1 inward currents and MUC5AC secretion. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-50 22328719-1 2012 Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 22328719-1 2012 Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 22328719-3 2012 One characteristic of TRPV1 is that channel activity induced by either capsaicin or other activators can be sensitized or modulated by factors involving different cell signaling mechanisms. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 22328719-9 2012 DIDS also potentiated the currents of TRPV1 channels expressed in human embryonic kidney 293 cells, with an effect of left-shifting the concentration-response curve of the capsaicin-induced TRPV1 currents. Capsaicin 172-181 transient receptor potential cation channel subfamily V member 1 Homo sapiens 38-43 22328719-9 2012 DIDS also potentiated the currents of TRPV1 channels expressed in human embryonic kidney 293 cells, with an effect of left-shifting the concentration-response curve of the capsaicin-induced TRPV1 currents. Capsaicin 172-181 transient receptor potential cation channel subfamily V member 1 Homo sapiens 190-195 22389490-1 2012 TRPV1 is a member of the transient receptor potential ion channel family and is gated by capsaicin, the pungent component of chili pepper. Capsaicin 89-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 22184123-3 2012 In rodents, TRPV3 is expressed predominantly in skin keratinocytes, whereas in humans TRPV1 and TRPV3 are co-expressed in sensory neurons of dorsal root ganglia and trigeminal ganglion and are known to form heteromeric channels with distinct single channel conductances as well as sensitivities to TRPV1 activator capsaicin and inhibitor capsazepine. Capsaicin 314-323 transient receptor potential cation channel subfamily V member 1 Homo sapiens 86-91 22242698-3 2012 The cation channel transient receptor potential vanilloid-1 (TRPV1) is activated by noxious stimuli, including capsaicin, protons, and high temperatures and is thought to have a role in inflammation. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-59 22242698-3 2012 The cation channel transient receptor potential vanilloid-1 (TRPV1) is activated by noxious stimuli, including capsaicin, protons, and high temperatures and is thought to have a role in inflammation. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 21906661-1 2012 The transient receptor potential vanilloid type 1 channel (TRPV1; originally vanilloid receptor VR1) is activated in peripheral terminals of nociceptive fibers by noxious heat, low pH, and natural products such as capsaicin, the pungent ingredient of red-hot chilli peppers. Capsaicin 214-223 transient receptor potential cation channel subfamily V member 1 Homo sapiens 59-64 21906661-1 2012 The transient receptor potential vanilloid type 1 channel (TRPV1; originally vanilloid receptor VR1) is activated in peripheral terminals of nociceptive fibers by noxious heat, low pH, and natural products such as capsaicin, the pungent ingredient of red-hot chilli peppers. Capsaicin 214-223 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-99 22143339-2 2012 RECENT FINDINGS: A significant amount of research has recently focused on the role of capsaicin and its receptors (TRPV1 and VR1), which can be found on sensory c-fibers in human nasal mucosa and play a critical role in the development of nasal hyperresponsiveness to environmental factors. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-120 22143339-2 2012 RECENT FINDINGS: A significant amount of research has recently focused on the role of capsaicin and its receptors (TRPV1 and VR1), which can be found on sensory c-fibers in human nasal mucosa and play a critical role in the development of nasal hyperresponsiveness to environmental factors. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 125-128 22737633-3 2012 First studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 is now recognized to have a broader distribution and function within the central nervous system (CNS). Capsaicin 61-70 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 22154816-2 2012 Activation of TRPV1 induces an influx of divalent and monovalent cations (i.e., Ca(2+), Na(+), and Mg(2+)) which are activated by capsaicin, heat, and acid. Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 22221101-0 2012 Transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside Rg1 on capsaicin-induced interleukin-8 and prostaglandin E2 production in HaCaT cells. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 22221101-5 2012 KEY FINDINGS: The results showed that GRg1 blocked intracellular calcium by both capsaicin and proton activation in a TRPV1-dependent manner. Capsaicin 81-90 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-123 23037991-3 2012 Capsaicin is a highly selective agonist for the transient receptor potential channel vanilloid-receptor type 1 (TRPV1), which is expressed on central and peripheral terminals of nociceptive primary sensory neurons. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-110 23037991-3 2012 Capsaicin is a highly selective agonist for the transient receptor potential channel vanilloid-receptor type 1 (TRPV1), which is expressed on central and peripheral terminals of nociceptive primary sensory neurons. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 23037991-5 2012 Topical application of capsaicin at the peripheral terminal of TRPV1-expressing neurons superficially denervates the epidermis in humans in a highly selective manner and results in hypoalgesia. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 22005042-1 2012 Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin. Capsaicin 326-335 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-64 22182671-7 2012 Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8). Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-48 22182671-7 2012 Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8). Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-139 22005042-1 2012 Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin. Capsaicin 326-335 transient receptor potential cation channel subfamily V member 1 Homo sapiens 66-71 22005042-1 2012 Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin. Capsaicin 352-361 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-64 22005042-1 2012 Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin. Capsaicin 352-361 transient receptor potential cation channel subfamily V member 1 Homo sapiens 66-71 22005042-4 2012 Here we show that the dihydropyridine derivative 4,5-diethyl-3-(2-methoxyethylthio)-2-methyl-6-phenyl-1,4-(+-)-dihydropyridine-3,5-dicarboxylate (MRS1477) behaves as a positive allosteric modulator of both proton and vanilloid activation of TRPV1. Capsaicin 217-226 transient receptor potential cation channel subfamily V member 1 Homo sapiens 241-246 23196561-6 2012 The administration of capsaicin as an agonist stimulus of TRPV1, a warm temperature receptor, decreased the delay in swallowing reflex. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 21981454-1 2011 AIM: Nasal transient receptor potential vanilloid 1 (TRPV1) stimulation with capsaicin produces serous and mucinous secretion in the human nasal airway. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 11-51 21962912-4 2011 Additionally, the agonists allyl isothiocyanate (TRPA1) and capsaicin (TRPV1) induce a differential secretion pattern of the eicosanoids PGE(2) and LTB(4) in human dermal fibroblasts and keratinocytes, which was also detectable invivo, analyzing suction blister fluid at various times after short-term topical application. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 71-76 21573941-2 2011 AIM: As capsaicin contained in red pepper is able to desensitize the TRPV(1) fibres, we evaluated whether the red pepper oral administration can decrease the symptoms of visceral hypersensitivity in IBS patients. Capsaicin 8-17 transient receptor potential cation channel subfamily V member 1 Homo sapiens 69-76 21892726-1 2011 TRPV1 is a Ca(2+) permeable cation channel gated by multiple stimuli including noxious heat, capsaicin, protons, and extracellular cations. Capsaicin 93-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 21892726-2 2011 In this paper, we show that Ca(2+) causes a concentration and voltage-dependent decrease in the capsaicin-gated TRPV1 single-channel conductance. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 21911503-1 2011 The capsaicin-, heat-, and proton-activated ion channel TRPV1, a member of the transient receptor potential cation channel family is a polymodal nociceptor. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 21911503-3 2011 Antagonists which block TRPV1 activation by capsaicin, heat, and protons were developed by a number of pharmaceutical companies. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 21829089-6 2011 Using the YO-PRO-1 based fluorescent dye uptake assay, we found that cap-ET effectively triggered Ca(2+) dependent desensitization of TRPV1 when the receptor was pre-sensitized with the surrogate oxidative chemical phenylarsine oxide (PAO), suggesting an alternative use of permanently charged cationic capsaicinoids in differential neuronal silencing. Capsaicin 303-316 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-139 21432926-5 2011 Of the herbals tested, Pipaye (Folium Eriobotryae) extracts, especially the 50% ethanol extract, showed the highest activity for the suppression of TRPV1 activation by its agonist capsaicin. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 148-153 21432926-7 2011 Thus the inhibition of capsaicin elicited Ca-flux in TRPV1 cells by Pipaye is largely due to desensitization of the receptor. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 21981454-1 2011 AIM: Nasal transient receptor potential vanilloid 1 (TRPV1) stimulation with capsaicin produces serous and mucinous secretion in the human nasal airway. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 21530339-11 2011 A degeneration of epidermal nerve fibers has previously been demonstrated for patches containing the TRPV1-agonist capsaicin and our findings suggest that this effect might also be relevant for lidocaine patches. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 101-106 21852280-10 2011 Peripheral neuropathic hypersensitivity is mediated by diverse mechanisms, including altered expression of the capsaicin receptor TRPV1 or other key ion channels in affected or intact adjacent peripheral nociceptive nerve fibres, aberrant re-innervation, and collateral sprouting, all of which are defunctionalized by topical capsaicin. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 130-135 21844219-7 2011 Furthermore, activation of TRPV1 by capsaicin led to a 54% reduction of KCNQ2/3-mediated current amplitude and attenuation of KCNQ2/3 activation. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 21667066-2 2011 The aim of our study was to assess the effect of mammalian vanilloid receptor subtype 1 (TRPV1) agonist (capsaicin) and antagonist (capsazepine) on insect behavioral thermoregulation. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 59-87 21667066-2 2011 The aim of our study was to assess the effect of mammalian vanilloid receptor subtype 1 (TRPV1) agonist (capsaicin) and antagonist (capsazepine) on insect behavioral thermoregulation. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 21667066-6 2011 The observed opposite effect of TRPV1 agonist and antagonist on insect behavioral thermoregulation, which is similar to the effect of these substances on thermoregulation in mammals, indicates indirectly that capsaicin may act on receptors in insects that are functionally similar to TRPV1. Capsaicin 209-218 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 21667066-6 2011 The observed opposite effect of TRPV1 agonist and antagonist on insect behavioral thermoregulation, which is similar to the effect of these substances on thermoregulation in mammals, indicates indirectly that capsaicin may act on receptors in insects that are functionally similar to TRPV1. Capsaicin 209-218 transient receptor potential cation channel subfamily V member 1 Homo sapiens 284-289 21666106-3 2011 Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin- and heat-gated nociceptive ion channel implicated in thermosensation and pathological pain under conditions of inflammation or injury. Capsaicin 54-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 21666106-3 2011 Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin- and heat-gated nociceptive ion channel implicated in thermosensation and pathological pain under conditions of inflammation or injury. Capsaicin 54-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 21666106-5 2011 We demonstrate that cold strongly suppressed the activation of recombinant TRPV1 by multiple agonists and capsaicin-evoked currents in trigeminal ganglia neurons under normal and phosphorylated conditions. Capsaicin 106-115 transient receptor potential cation channel subfamily V member 1 Homo sapiens 75-80 21861907-4 2011 LA-induced activation and sensitization of TRPV1 involves a domain that is similar, but not identical to the vanilloid-binding domain. Capsaicin 109-118 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-48 21671576-6 2011 The preliminary biological studies have allowed the identification of some of the key structural features directing the blockage of capsaicin-induced Ca(2+) influx through TRPV1 channels, particularly, the strong preference showed for highly lipophilic acyl groups and substituted guanidine moieties. Capsaicin 132-141 transient receptor potential cation channel subfamily V member 1 Homo sapiens 172-177 21636531-8 2011 Capsaicin and acid induced IL-8 production in Het1A cells, and this production was diminished by antagonists of TRPV1. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 21636531-2 2011 Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive, Ca(2+)-selective ion channel activated by capsaicin, heat, and protons. Capsaicin 109-118 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 21636531-2 2011 Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive, Ca(2+)-selective ion channel activated by capsaicin, heat, and protons. Capsaicin 109-118 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 21215321-3 2011 Inhalation of capsaicin aerosol, a selective agonist of TRPV1, consistently and reproducibly evoked coughs in a dose-dependent manner in both healthy humans and in patients with airway inflammatory diseases. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 21575625-6 2011 JNJ-39729209 displaced tritiated resiniferotoxin binding to TRPV1 and prevented TRPV1 activation by capsaicin, protons and heat. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 80-85 21502857-12 2011 At subactivating concentrations (less than 1 mM), QX-314 potently inhibited capsaicin-evoked TRPV1 currents with an IC50 of 8.0 +- 0.6 muM. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 93-98 21502857-13 2011 CONCLUSIONS: The results of this study show that the quaternary lidocaine derivative QX-314 exerts biphasic effects on TRPV1 channels, inhibiting capsaicin-evoked TRPV1 currents at lower (micromolar) concentrations and activating TRPV1 channels at higher (millimolar) concentrations. Capsaicin 146-155 transient receptor potential cation channel subfamily V member 1 Homo sapiens 119-124 21502857-13 2011 CONCLUSIONS: The results of this study show that the quaternary lidocaine derivative QX-314 exerts biphasic effects on TRPV1 channels, inhibiting capsaicin-evoked TRPV1 currents at lower (micromolar) concentrations and activating TRPV1 channels at higher (millimolar) concentrations. Capsaicin 146-155 transient receptor potential cation channel subfamily V member 1 Homo sapiens 163-168 21502857-13 2011 CONCLUSIONS: The results of this study show that the quaternary lidocaine derivative QX-314 exerts biphasic effects on TRPV1 channels, inhibiting capsaicin-evoked TRPV1 currents at lower (micromolar) concentrations and activating TRPV1 channels at higher (millimolar) concentrations. Capsaicin 146-155 transient receptor potential cation channel subfamily V member 1 Homo sapiens 163-168 21474332-3 2011 Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 161-166 21393555-5 2011 Third, LPS significantly sensitized TRPV1 to capsaicin measured by (Ca(2+))(i), release of calcitonin gene-related peptide, and inward currents. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-41 21523557-1 2011 Extensively based on evidence gained from experimental animal models, the transient receptor potential vanilloid receptor type 1 (TRPV1)-activator capsaicin is regarded as a valuable tool in the research on neurogenic inflammation. Capsaicin 147-156 transient receptor potential cation channel subfamily V member 1 Homo sapiens 130-135 21550252-6 2011 The CHEP after application of capsaicin show features observed in some patients with painful neuropathy, and could provide a model for development of novel analgesics, particularly TRPV1 antagonists. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 181-186 21623392-2 2011 TRPV1 channel is expressed in the beta cells and capsaicin induces insulin secretion similarly to glucose. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 21536874-0 2011 Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog. Capsaicin 61-70 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 21536874-5 2011 We synthesized a series of permanently charged capsaicinoids and found that one, cap-ET, efficaciously evoked TRPV1-dependent entry of Ca(2+) or the large cationic dye YO-PRO-1 comparably to capsaicin, but far smaller electrical currents. Capsaicin 47-60 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 21536874-5 2011 We synthesized a series of permanently charged capsaicinoids and found that one, cap-ET, efficaciously evoked TRPV1-dependent entry of Ca(2+) or the large cationic dye YO-PRO-1 comparably to capsaicin, but far smaller electrical currents. Capsaicin 47-56 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 21310942-0 2011 Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 21310942-1 2011 Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 132-177 21310942-1 2011 Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 179-184 21310942-1 2011 Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1). Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 132-177 21310942-1 2011 Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1). Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 179-184 21310942-2 2011 Herein, we provide evidence that CPS treatment induced a more aggressive gene phenotype and invasiveness in 5637 cells-lacking TRPV1 receptor. Capsaicin 33-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 127-132 21310942-6 2011 We found that TRPV1-expressing cells show CPS-mediated calcium level increase, growth inhibition and apoptosis. Capsaicin 42-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 21310942-7 2011 Moreover, CPS-induced migration and MMP9 activation were reverted, suggesting an inhibitory role played by TRPV1 in urothelial cancer cell invasion and metastasis. Capsaicin 10-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 21654202-5 2011 This review summarizes the current knowledge of the molecular determinants of TRPV1 channel activation by heat, protons and capsaicin. Capsaicin 124-133 transient receptor potential cation channel subfamily V member 1 Homo sapiens 78-83 21343315-8 2011 This study provides vital information on the molecular interactions of capsaicinoids with TRPV1 and substantiates TRPV1-mediated ER stress as a conserved mechanism of lung cell death by prototypical TRPV1 agonists. Capsaicin 71-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 90-95 21215315-0 2011 N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity. Capsaicin 64-73 transient receptor potential cation channel subfamily V member 1 Homo sapiens 125-130 21345654-4 2011 METHODS: TRPV1 antagonistic effects of PAC-14028 in human keratinocytes and skin were confirmed through capsaicin-evoked calcium influx assay and capsaicin-induced blood perfusion increase. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 9-14 21345654-4 2011 METHODS: TRPV1 antagonistic effects of PAC-14028 in human keratinocytes and skin were confirmed through capsaicin-evoked calcium influx assay and capsaicin-induced blood perfusion increase. Capsaicin 146-155 transient receptor potential cation channel subfamily V member 1 Homo sapiens 9-14 21215315-6 2011 Accordingly, palvanil desensitized the human recombinant TRPV1 to the effect of capsaicin (10nM) with significantly higher potency than capsaicin (IC(50)=0.8nM and 3.8nM, respectively), this effect reaching its maximum more rapidly (50 and 250min, respectively). Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 57-62 21215315-7 2011 Palvanil was also more potent than capsaicin at desensitizing the stimulatory effect of TRPV1 by low pH together with anandamide, which mimics conditions occurring during inflammation. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 21215315-10 2011 In conclusion, palvanil appears to be a non-pungent analogue of capsaicin with stronger desensitizing effects on TRPV1 and hence potentially higher anti-hyperalgesic activity. Capsaicin 64-73 transient receptor potential cation channel subfamily V member 1 Homo sapiens 113-118 21351130-4 2011 TRPV1 function was assessed by capsaicin (CAP, 6 microM)-evoked intracellular calcium ([Ca(2+)](i)) changes measured by microfluorimetry imaging. Capsaicin 31-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 21351130-4 2011 TRPV1 function was assessed by capsaicin (CAP, 6 microM)-evoked intracellular calcium ([Ca(2+)](i)) changes measured by microfluorimetry imaging. Capsaicin 42-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 21285946-3 2011 The mechanisms of heat and capsaicin activation have been linked to voltage-dependent gating in TRPV1. Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-101 21056583-5 2011 KEY FINDINGS: Xenon (75%) reduced the number of primary sensory neurons responding to the TRPV1 agonist, capsaicin (100 nM-1 muM) by ~25% to ~50%. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 90-95 21056583-8 2011 SIGNIFICANCE: Xenon substantially reduces the activity of TRPV1 in response to noxious stimulation by the specific TRPV1 agonist, capsaicin, suggesting a possible role for xenon as an adjunct analgesic where hTRPV1 is an active contributor to the excitation of primary afferents which initiates the pain sensation. Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 21056583-8 2011 SIGNIFICANCE: Xenon substantially reduces the activity of TRPV1 in response to noxious stimulation by the specific TRPV1 agonist, capsaicin, suggesting a possible role for xenon as an adjunct analgesic where hTRPV1 is an active contributor to the excitation of primary afferents which initiates the pain sensation. Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-120 21056583-8 2011 SIGNIFICANCE: Xenon substantially reduces the activity of TRPV1 in response to noxious stimulation by the specific TRPV1 agonist, capsaicin, suggesting a possible role for xenon as an adjunct analgesic where hTRPV1 is an active contributor to the excitation of primary afferents which initiates the pain sensation. Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 208-214 21294877-4 2011 We demonstrate that TRPV1 is not expressed in all the same cells as SP following capsaicin induction suggesting the presence of a non-cell autonomous mechanism for TAC1 up-regulation following capsaicin induction. Capsaicin 193-202 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 21056583-6 2011 Xenon reduced the number of heterologously-expressed hTRPV1 activated by 300 nM capsaicin by ~50%. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-59 21158551-5 2011 The action of capsaicin on the transient receptor potential cation channel, subfamily V, member 1 receptors will be discussed. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-97 20932251-3 2011 Depending on the duration of capsaicin exposure and the external calcium concentration, the Ca(2+) influx via TRPV1 channels desensitizes the channels themselves, which, from the cellular point of view, represents a feedback mechanism protecting the nociceptive neuron from toxic Ca(2+) overload. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 20932253-1 2011 The transient receptor potential vanilloid type 1 ion channel (TRPV1) was identified as a receptor responsible for mediating the intense burning sensation following exposure to heat greater than approximately 43 C., or capsaicin, the pungent ingredient of hot chilli peppers. Capsaicin 219-228 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 20932253-5 2011 The widespread expression of TRPV1 in the human suggests that, in addition to the development of burning pain associated with acute exposure to heat or capsaicin, and with inflammation, TRPV1 may also be involved in an array of vitally important functions, such as those of the urinary tract, the respiratory and auditory systems. Capsaicin 152-161 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 21258172-7 2011 The administration of a pastille with capsaicin as an agonist stimulus of TRPV1, a warm-temperature receptor, decreased the delay in swallowing reflex. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 32272547-7 2011 The administration of a pastille with capsaicin as an agonist stimulus of TRPV1, a warm-temperature receptor, decreased the delay in swallowing reflex. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 22171160-7 2011 RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 22171160-7 2011 RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release. Capsaicin 20-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 21779403-10 2011 Furthermore, we found that protons and capsaicin likewise synergistically potentiated the response of TRPV1 to hypertonic stimuli. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-107 21671878-4 2011 This has rekindled interest in desensitization of nociceptive neurons to TRPV1 agonists (e.g. capsaicin and its ultrapotent analog resiniferatoxin) as an alternative pharmacological approach to block pain in the periphery where it is generated. Capsaicin 94-103 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 20924599-1 2011 Acid-sensing ion channels (ASICs) are neuronal H(+)-gated cation channels, and the transient receptor potential vanilloid 1 channel (TRPV1) is a multimodal cation channel activated by low pH, noxious heat, capsaicin, and voltage. Capsaicin 206-215 transient receptor potential cation channel subfamily V member 1 Homo sapiens 133-138 21044960-1 2010 The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3. Capsaicin 190-199 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 21044960-1 2010 The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3. Capsaicin 190-199 transient receptor potential cation channel subfamily V member 1 Homo sapiens 372-377 21044960-4 2010 We mutated charged residues all along the S4 and the S4-S5 linker of TRPV1 and identified four potential voltage-sensing residues (Arg(557), Glu(570), Asp(576), and Arg(579)) that, when specifically mutated, altered the functionality of the channel with respect to voltage, capsaicin, heat, 2-APB, and/or their interactions in different ways. Capsaicin 274-283 transient receptor potential cation channel subfamily V member 1 Homo sapiens 69-74 21123568-6 2010 Importantly, directly elevating spiking in individual postsynaptic neurons, by capsaicin activation of overexpressed TRPV1 channels, was sufficient to induce increased mIPSC amplitude and frequency, mimicking the effect of elevated neuronal activity. Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 117-122 20626462-4 2010 Furthermore, skin sensitivity towards capsaicin, a natural activator of TRPV1, was shown to correlate with sensitive skin. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 20539001-10 2010 In contrast, high concentrations of 2-APB (3 mM) increased [Ca(2+)](i), whereas the TRPV1 channel opener capsaicin and the TRPV3 channel opener camphor had no effect. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 84-89 20884761-6 2010 Bath application of 2AG or the TRPV1 agonists capsaicin and resiniferatoxin mimicked LTD and both capsaicin- and 2AG-induced depression were blocked by capsazepine. Capsaicin 46-55 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 20884761-6 2010 Bath application of 2AG or the TRPV1 agonists capsaicin and resiniferatoxin mimicked LTD and both capsaicin- and 2AG-induced depression were blocked by capsazepine. Capsaicin 98-107 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 20626462-6 2010 This antagonist is able to inhibit capsaicin-induced hTRPV1 activation with an IC(50) value of 34 +- 5 mum tested in HEK293-cells as well as in electrophysiological recordings performed in oocytes expressing hTRPV1. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-59 20626462-6 2010 This antagonist is able to inhibit capsaicin-induced hTRPV1 activation with an IC(50) value of 34 +- 5 mum tested in HEK293-cells as well as in electrophysiological recordings performed in oocytes expressing hTRPV1. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 208-214 20937102-1 2010 Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed endovanilloids. Capsaicin 123-132 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 20980604-10 2010 Such results suggest that activated, presynaptic TRPV1+ receptors trigger continuous resting release of glutamate vesicles at physiological temperatures only in capsaicin-responsive terminals. Capsaicin 161-170 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 20937102-1 2010 Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed endovanilloids. Capsaicin 123-132 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 21169106-2 2010 Stimulation of TRPV1 receptors with capsaicin may induce heartburn. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 21156013-7 2010 TRPV1 is co-expressed with TRPA1, and TRPA1 is known to be present on capsaicin-sensitive primary sensory neurones. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 21103419-4 2010 Epithelial cells contain TRPV1 receptor mRNA and protein and respond to HCl and to the TRPV1 agonist capsaicin with production of PAF. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 21169106-3 2010 Capsaicin is the pungent component of chili and the most extensively studied TRPV1 agonist. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 20639579-7 2010 Functional analysis of TRPV1-I585V, using the Ca(2+)-sensitive dye fura-2 to measure intracellular [Ca(2+)] concentrations, revealed a decreased channel activity in response to two typical TRPV1 stimuli, heat and capsaicin. Capsaicin 213-222 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-28 20639579-7 2010 Functional analysis of TRPV1-I585V, using the Ca(2+)-sensitive dye fura-2 to measure intracellular [Ca(2+)] concentrations, revealed a decreased channel activity in response to two typical TRPV1 stimuli, heat and capsaicin. Capsaicin 213-222 transient receptor potential cation channel subfamily V member 1 Homo sapiens 189-194 20586701-1 2010 IMPORTANCE OF THE FIELD: Transient receptor potential vanilloid-1 (TRPV1, vanilloid receptor-1) is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by capsaicin, the active ingredient in chili peppers. Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-65 20619260-3 2010 Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 20619260-3 2010 Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response. Capsaicin 82-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 20586701-1 2010 IMPORTANCE OF THE FIELD: Transient receptor potential vanilloid-1 (TRPV1, vanilloid receptor-1) is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by capsaicin, the active ingredient in chili peppers. Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 20462348-4 2010 We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1). Capsaicin 51-60 transient receptor potential cation channel subfamily V member 1 Homo sapiens 176-224 20615696-1 2010 The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a non-selective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Capsaicin 181-190 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-70 20615696-1 2010 The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a non-selective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Capsaicin 181-190 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 20462348-4 2010 We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1). Capsaicin 51-60 transient receptor potential cation channel subfamily V member 1 Homo sapiens 226-231 20462348-4 2010 We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1). Capsaicin 138-147 transient receptor potential cation channel subfamily V member 1 Homo sapiens 176-224 20462348-4 2010 We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1). Capsaicin 138-147 transient receptor potential cation channel subfamily V member 1 Homo sapiens 226-231 20371865-6 2010 Capsaicin, an agonist of VR1, increased intracellular free calcium, enhanced phosphorylation of extracellular signal-regulated kinase, and induced the trafficking of aquaporin 5 (AQP5) from the cytoplasm to the plasma membrane. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-28 20360133-3 2010 The purpose of this study was to verify whether activation of TRPV1 by capsaicin could improve the secretion of transplanted gland and its underlying mechanism. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-67 20360133-5 2010 Topical capsaicin cream increased secretion and upregulated levels of TRPV1 and AQP5 in transplanted glands. Capsaicin 8-17 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 20360133-6 2010 Moreover, in cultured submandibular gland cells, capsaicin increased the mRNA expression of AQP5 and led to redistribution of AQP5 from the cytoplasm to the plasma membrane via TRPV1 activation. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 177-182 20360133-9 2010 In summary, the capsaicin-induced secretory mechanism involved activation of TRPV1 and upregulation of AQP5 in an ERK-dependent manner and promoted the redistribution of AQP5 in submandibular gland cells. Capsaicin 16-25 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 20354008-0 2010 Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population. Capsaicin 16-25 transient receptor potential cation channel subfamily V member 1 Homo sapiens 104-152 20338165-7 2010 TRPV1-3 functional activity was evident based on capsaicin-induced Ca(2+) transients and induction of these responses through rises in ambient temperature from 25 degrees C to over 40 degrees C. The currents underlying Ca(2+) transients were characterized with a novel high throughput patch-clamp system. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-7 20338165-8 2010 The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 20338165-8 2010 The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 180-185 20338165-8 2010 The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium. Capsaicin 40-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 20338165-8 2010 The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium. Capsaicin 40-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 180-185 20179142-5 2010 Functionally, GABARAP expression attenuated voltage and capsaicin sensitivity of TRPV1 in the presence of extracellular calcium. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 81-86 20446852-2 2010 IMPORTANCE OF THE FIELD: Capsaicin and its receptor, TRPV1, occupy a central place in current neurophysiological studies regarding pain transmission and have opened new avenues for understanding the role of transient receptor potential (TRP) receptors in itch processing. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 20179142-8 2010 Disruption of tubulin cytoskeleton with nocodazole reduced capsaicin-evoked currents in cells expressing TRPV1 and GABARAP, without affecting the kinetics of vanilloid-induced desensitization. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 105-110 20646592-12 2010 CONCLUSION: Capsaicin induces the cell cycle arrest of bladder cancer RT4 cells G(0)/G(1) phase and growth inhibition via TRPV1 receptor by modulating the expression of P53, P21 and CDK2. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 20419599-2 2010 TRPV1 mediates the tussive action of capsaicin, which is widely used in cough provocation studies. Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 20354008-7 2010 RESULTS: The TRPV1-selective agonist capsaicin, and the endovanilloids anandamide and N-arachidonoyl-dopamine (NADA), induced TRPV1-dependent delayed cell death in a concentration- and time-dependent manner. Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 20354008-7 2010 RESULTS: The TRPV1-selective agonist capsaicin, and the endovanilloids anandamide and N-arachidonoyl-dopamine (NADA), induced TRPV1-dependent delayed cell death in a concentration- and time-dependent manner. Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 20354008-10 2010 CONCLUSIONS: We conclude that capsaicin, anandamide, and NADA can initiate TRPV1-dependent delayed cell death in neurone-like cells. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 75-80 20145248-1 2010 The capsaicin receptor (TRPV1) is a nonselective cation channel that integrates multiple painful stimuli, including capsaicin, protons, and heat. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 20176082-6 2010 Similar to ACEA, the vanilloid agonist capsaicin increased quantal content, and this effect was blocked by capsazepine, a TRPV1 antagonist. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 20145248-2 2010 Protons facilitate the capsaicin- and heat-induced currents by decreasing thermal threshold or increasing agonist potency for TRPV1 activation (Tominaga, M., Caterina, M. J., Malmberg, A. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 20145248-5 2010 Human TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin. Capsaicin 145-154 transient receptor potential cation channel subfamily V member 1 Homo sapiens 6-11 20145248-5 2010 Human TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin. Capsaicin 145-154 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-19 20145248-7 2010 By analysis of chimeric channels between hTRPV1 and rTRPV1, we found that transmembrane domain 1-4 (TM1-4) of TRPV1 determines whether protons can further open the fully capsaicin-bound receptors. Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-47 20145248-7 2010 By analysis of chimeric channels between hTRPV1 and rTRPV1, we found that transmembrane domain 1-4 (TM1-4) of TRPV1 determines whether protons can further open the fully capsaicin-bound receptors. Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 20145248-9 2010 In contrast, hTRPV1 TM5-6 is required for magnesium augmentation of capsaicin efficacy. Capsaicin 68-77 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-19 20145248-10 2010 Our results demonstrate that capsaicin efficacy of hTRPV1 correlates with the extracellular ion milieu and unravel the relevant structural basis of modulation by protons and magnesium. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-57 20686244-1 2010 Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel activated by capsaicin. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-48 20535343-6 2010 Capsaicin can mediate a painful, burning sensation in the human gut via the transient receptor potential vanilloid-1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-116 20535343-6 2010 Capsaicin can mediate a painful, burning sensation in the human gut via the transient receptor potential vanilloid-1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-123 20347391-3 2010 Trigeminal nociceptors express the heat- and capsaicin-gated channel TRPV1, which seems to play a significant role in the development of peripheral and central sensitisation and of hyperalgesia and allodynia. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 69-74 19944080-5 2010 The TRPV1 agonist capsaicin (CAP, 100 nM) was used to identify afferent, CAP-sensitive terminals arising from unmyelinated afferents. Capsaicin 18-27 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 20040737-2 2010 The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 79-119 20040737-2 2010 The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 121-126 20040737-8 2010 Taken together, our results indicate that curcumin blocks capsaicin-induced TRPV1 activation and thereby inhibits TRPV1-mediated pain hypersensitivity. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 20686244-6 2010 The dose-response curves for TRPV1 activation by the essential oils revealed a rank order potency [the half-maximal effective concentration (EC(50))] of rose>palmarosa>thyme geraniol>tolu balsam, and rank order efficiency (% activity in response to 1 microM capsaicin) of tolu balsam>rose>palmarosa>thyme geraniol. Capsaicin 267-276 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 19879868-3 2010 It has been found that TRPV1 could be activated by endogenous ligands such as anandamide, N-arachidonoyl dopamine and N-oleoyldopamine or by exogenous agonists such as capsaicin and rutaecarpine. Capsaicin 168-177 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-28 19959817-2 2010 In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 19959817-2 2010 In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 19959817-2 2010 In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel. Capsaicin 133-142 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 19959817-2 2010 In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel. Capsaicin 133-142 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 19570606-2 2010 Recent reports have demonstrated that tumor cells express TRPV1 and that capsaicin (CP), a ligand for TRPV1, induces apoptosis in cancer cells. Capsaicin 73-82 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-107 20166923-2 2010 These experiments were initially based on the observation that the endocannabinoid anandamide and the xenobiotic ligand of TRP channels of V1 type (TRPV1), capsaicin, are somehow chemically similar, both compounds being fatty acid amides, as are also synthetic activators of these channels and inhibitors of anandamide cellular re-uptake. Capsaicin 156-165 transient receptor potential cation channel subfamily V member 1 Homo sapiens 148-153 20686244-1 2010 Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel activated by capsaicin. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 19770677-1 2010 OBJECTIVES: Capsaicin/vanilloid (transient receptor potential vanilloid 1, (TRPV1) receptor has been shown to be expressed in gastrointestinal tract and play a role as a member of sensory ion channel superfamily. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 19846148-8 2009 Capsaicin (100 nM and 1 microM) and heat (41C and 45C) evoked cobalt uptake and inflammatory mediators lowered the temperature threshold for TRPV1 activation to 37C. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 141-146 19846148-9 2009 Capsaicin (1 microM) induced TRPV1 desensitization to further applications of the agonist. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 19846148-12 2009 CONCLUSIONS: TRPV1 receptors expressed by human urothelial cells respond to capsaicin and thermal stimuli. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 19846148-13 2009 Capsaicin evoked release of adenosine triphosphate suggests that human urothelial TRPV1 is involved in the afferent branch of the micturition reflex. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 19778904-4 2009 Activation of TRPV1(ER) with capsaicin or other vanilloids produced an increase of cytosolic Ca(2+) due to Ca(2+) release from the ER. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 19778904-6 2009 The sensitivity of TRPV1(ER) to capsaicin was smaller than the sensitivity of the plasma membrane TRPV1 channels. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-24 19540328-6 2009 The response was quantified as the product induced Ca(2+) influx during 2 min in relation to the maximum response induced by the TRPV1 agonist capsaicin. Capsaicin 143-152 transient receptor potential cation channel subfamily V member 1 Homo sapiens 129-134 19778904-7 2009 The low affinity of TRPV1(ER) was not related to protein kinase A- or C-mediated phosphorylations, but it was due to inactivation by cytosolic Ca(2+) because the sensitivity to capsaicin was increased by loading the cells with the Ca(2+) chelator BAPTA. Capsaicin 177-186 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 19778904-9 2009 Disruption of the TRPV1 calmodulin-binding domains at either the C terminus (Delta35AA) or the N terminus (K155A) increased 10-fold the affinity of TRPV1(ER) for capsaicin, suggesting that calmodulin is involved in the inactivation. Capsaicin 162-171 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-23 19778904-9 2009 Disruption of the TRPV1 calmodulin-binding domains at either the C terminus (Delta35AA) or the N terminus (K155A) increased 10-fold the affinity of TRPV1(ER) for capsaicin, suggesting that calmodulin is involved in the inactivation. Capsaicin 162-171 transient receptor potential cation channel subfamily V member 1 Homo sapiens 148-153 19778904-10 2009 The lack of TRPV1 sensitizers, such as phosphatidylinositol 4,5-bisphosphate, in the ER could contribute to decrease the affinity for capsaicin. Capsaicin 134-143 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 19619644-1 2009 Transient receptor potential vanilloid (TRPV) 1 channels function as sensors for a variety of noxious and inflammatory signals, including capsaicin, heat and protons, and are up-regulated under inflammatory conditions. Capsaicin 138-147 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-47 19562439-9 2009 Unidentified isolectin B4 (IB4)-positive but TRPV1-negative small neurons with a higher noxious heat threshold are feasible, because a spliced isoform of TRPV1 responsive to noxious heat (47 degrees C) but not responsive to either proton or capsaicin is present in human and rat sensory neurons. Capsaicin 241-250 transient receptor potential cation channel subfamily V member 1 Homo sapiens 154-159 19566590-3 2009 Exposure of TRPV(1) to capsaicin is characterized by activation, followed by desensitization. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-19 19566590-12 2009 Oesophageal instillation of the TRPV(1) receptor agonist capsaicin induces symptoms of retrosternal and epigastric burning in a dose-dependent fashion. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-39 19852757-3 2009 TRPV1, also known as the vanilloid receptor (VR1), is activated by ligands such as capsaicin, acidic pH, and heat (an increase in temperature to approximately 42 degrees C will lead to channel opening). Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 19852757-3 2009 TRPV1, also known as the vanilloid receptor (VR1), is activated by ligands such as capsaicin, acidic pH, and heat (an increase in temperature to approximately 42 degrees C will lead to channel opening). Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-48 19477951-9 2009 TRPV1 channel activation with capsaicin failed to activate ERK. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 19686135-4 2009 This is illustrated by the use of capsaicin, menthol, and wasabi to identify the heat-sensitive ion channel TRPV1, the cold-sensitive ion channel TRPM8, and the irritant receptor TRPA1, respectively. Capsaicin 34-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 108-113 19389802-3 2009 Contraction was similarly abolished by supernatant of mucosal sac filled with the TRPV1 agonist capsaicin (10(-6) M). Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 19695100-3 2009 RESULTS: Fluorescent imaging of Fura-2 loaded human SW982 synoviocytes reveals immediate and delayed cytosolic calcium oscillations elicited by (1) TRPV1 agonists capsaicin and resiniferatoxin (20-40% of cells), (2) moderate and noxious temperature change, and (3) osmotic stress TRPV4 activation (11.5% of cells). Capsaicin 163-172 transient receptor potential cation channel subfamily V member 1 Homo sapiens 148-153 19502594-0 2009 Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-59 19502594-0 2009 Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 19502594-1 2009 Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS). Capsaicin 211-220 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-94 19502594-1 2009 Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS). Capsaicin 211-220 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-101 19502594-1 2009 Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS). Capsaicin 222-225 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-94 19502594-1 2009 Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS). Capsaicin 222-225 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-101 19602228-9 2009 Further studies revealed that TDAG8 activation sensitized the TRPV1 response to capsaicin, suggesting that TDAG8 could be involved in CFA-induced chronic inflammatory pain through regulation of TRPV1 function. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-67 19602228-9 2009 Further studies revealed that TDAG8 activation sensitized the TRPV1 response to capsaicin, suggesting that TDAG8 could be involved in CFA-induced chronic inflammatory pain through regulation of TRPV1 function. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 194-199 19561608-4 2009 We show that access to the pore of TRPV1 is gated by S6 in response to both capsaicin binding and increases in temperature, that the pore-forming S6 segments are helical structures and that two constrictions are present in the pore: one that impedes the access of large molecules and the other that hampers the access of smaller ions and constitutes an activation gate of these channels. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-40 19369364-2 2009 The TRPV1 receptors are expressed on both the peripheral and central branches of these dorsal root ganglion (DRG) neurons and can be activated by capsaicin, heat, low pH, and also by recently described endogenous lipids. Capsaicin 146-155 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 19161409-1 2009 Transient receptor potential vanilloid type 1 (TRPV1) is activated by various stimuli including capsaicin, heat and acid. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 19294370-2 2009 TRPV1 receptors can be activated by noxious heat, acid, capsaicin and resiniferatoxin, leading to burning pain or itch mediated by discharges in C polymodal and Adelta mechano-heat nociceptors and in central neurons, including spinothalamic tract (STT) cells. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 19361196-2 2009 Binding of 4alpha-phorbol esters occurs in a loop in the TM3-TM4 domain of TRPV4 that is analogous to the capsaicin binding site of TRPV1, and the ester decoration of ring C and the A,B ring junction are critical for activity. Capsaicin 106-115 transient receptor potential cation channel subfamily V member 1 Homo sapiens 132-137 19220220-3 2009 METHODS: Nasal challenges were carried out with the TRPV1-activators capsaicin, anandamide and olvanil. Capsaicin 69-78 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 19223122-6 2009 At a negative holding potential, the P2X(3) receptor agonist alpha,beta-meATP induced less current in the presence of the TRPV1 agonist capsaicin than that in its absence. Capsaicin 136-145 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 19206161-1 2009 Transient receptor potential vanilloid type 1 (TRPV1) is a molecular sensor for detecting adverse stimuli, such as capsaicin, heat, and acid. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 19206161-1 2009 Transient receptor potential vanilloid type 1 (TRPV1) is a molecular sensor for detecting adverse stimuli, such as capsaicin, heat, and acid. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 19397909-3 2009 Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-30 19397909-3 2009 Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 19121396-3 2009 The functional activity of the expressed TRPV1 was confirmed by whole-cell ligand-gated ion flux recordings in the presence of capsaicin and low pH and via specific ligand binding to the isolated cellular membranes. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 19150372-2 2009 TRPV1 is considered as a highly validated pain target because, i) its agonists such as capsaicin cause desensitization of TRPV1 channels that relieves pain behaviors in preclinical species, and ii) its antagonists relieve pain behaviors in rodent models of inflammation, osteoarthritis, and cancer. Capsaicin 87-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 19150372-2 2009 TRPV1 is considered as a highly validated pain target because, i) its agonists such as capsaicin cause desensitization of TRPV1 channels that relieves pain behaviors in preclinical species, and ii) its antagonists relieve pain behaviors in rodent models of inflammation, osteoarthritis, and cancer. Capsaicin 87-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 19161409-1 2009 Transient receptor potential vanilloid type 1 (TRPV1) is activated by various stimuli including capsaicin, heat and acid. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 19267374-0 2009 Synthesis and vanilloid receptor (TRPV1) activity of the enantiomers of alpha-fluorinated capsaicin. Capsaicin 90-99 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 18769453-4 2009 Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 19135797-1 2009 Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands. Capsaicin 163-172 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 19135797-1 2009 Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands. Capsaicin 163-172 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 19208258-11 2009 The expression of TRP channels has been shown in other areas of the CNS; application of 4alpha-PDD significantly increased the mEPSC frequency in cultured hippocampal neurons, which was further potentiated by PDBu, whereas, TRPV1 agonist capsaicin did not modulate synaptic transmission. Capsaicin 238-247 transient receptor potential cation channel subfamily V member 1 Homo sapiens 224-229 18769453-4 2009 Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 18769453-4 2009 Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 19036069-7 2009 The TRPV1 agonist, capsaicin, evoked both Ca(2+) influx and Ca(2+) release from intracellular stores, responses that were blocked in a dose-dependent manner by the TRPV1 antagonists, 5"-Iodo-resiniferatoxin (5"-Iodo-RTX) and AMG 9810. Capsaicin 19-28 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 19036069-7 2009 The TRPV1 agonist, capsaicin, evoked both Ca(2+) influx and Ca(2+) release from intracellular stores, responses that were blocked in a dose-dependent manner by the TRPV1 antagonists, 5"-Iodo-resiniferatoxin (5"-Iodo-RTX) and AMG 9810. Capsaicin 19-28 transient receptor potential cation channel subfamily V member 1 Homo sapiens 164-169 18987162-7 2009 MS reversibly inhibited hTRPV1 activation by polymodal stimuli such as capsaicin, protons, heat, anandamide, and 2-aminoethoxydiphenyl borate. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-30 18987162-8 2009 Because both the stimulatory and inhibitory actions of MS were exhibited in capsaicin- and allicin-insensitive mutant channels, MS-induced hTRPV1 activation was mediated by distinct channel regions from capsaicin and allicin. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 139-145 18987162-8 2009 Because both the stimulatory and inhibitory actions of MS were exhibited in capsaicin- and allicin-insensitive mutant channels, MS-induced hTRPV1 activation was mediated by distinct channel regions from capsaicin and allicin. Capsaicin 203-212 transient receptor potential cation channel subfamily V member 1 Homo sapiens 139-145 19049892-2 2009 It has been reported that ethanol sensitizes the transient receptor potential vanilloid-1 (TRPV1) to various stimuli and inhalation of ethanol enhances the cough mediated by TRPV1 activation (capsaicin) in patients suffering of airway sensory hyperreactivity. Capsaicin 192-201 transient receptor potential cation channel subfamily V member 1 Homo sapiens 174-179 19243225-3 2009 Here we address the problem at the receptor level and show that the capsaicin ion channel TRPV1, which mediates nociception at the peripheral nerve terminals, possesses properties essential to the adaptation of sensory responses. Capsaicin 68-77 transient receptor potential cation channel subfamily V member 1 Homo sapiens 90-95 19317053-7 2009 Pimecrolimus cream 1% may act on the transient potential vanilloid 1 (TRPV1) receptor in the skin sensory afferents to induce capsaicin-like response or camphor-like response and then desensitizes TRPV1 and rapidly inhibits or alleviate itching. Capsaicin 126-135 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 19129393-4 2009 Ammonia and intracellular alkalization activate TRPV1 through a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such as heat, capsaicin or low pH. Capsaicin 168-177 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-53 19059400-1 2009 In this study, capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) induced an increase in the cell viability of the androgen-responsive prostate cancer LNCaP cells, which was reversed by the use of the TRPV1 antagonists capsazepine, I-RTX and SB 366791. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 201-206 19059400-1 2009 In this study, capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) induced an increase in the cell viability of the androgen-responsive prostate cancer LNCaP cells, which was reversed by the use of the TRPV1 antagonists capsazepine, I-RTX and SB 366791. Capsaicin 26-64 transient receptor potential cation channel subfamily V member 1 Homo sapiens 201-206 19059400-4 2009 Capsaicin induced an increase in the AR expression that was reverted by the three TRPV1 antagonists. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 19275664-4 2009 Initially, the focus was on the development of TRPV1 agonists e.g. capsaicin and resiniferatoxin (RTX) as analgesic agents through the desensitization/denervation approach. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 20203492-3 2009 RESULTS: Capsaicin (TRPV1) receptor channels are expressed along the axonal membrane and respond to acidic, thermal and capsaicin stimulation with a graded and calcium-dependent calcitonin gene-related peptide release. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 20203492-3 2009 RESULTS: Capsaicin (TRPV1) receptor channels are expressed along the axonal membrane and respond to acidic, thermal and capsaicin stimulation with a graded and calcium-dependent calcitonin gene-related peptide release. Capsaicin 120-129 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 18825335-5 2009 Much interest has been directed to the study of the TRPV1, because capsaicin has been instrumental in discovering the unique role of a subset of primary sensory neurons in causing nociceptive responses, in activating reflex pathways including cough, and in producing neurogenic inflammation. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 18930149-3 2009 Pharmacological stimulation of TRPV1 channels with capsaicin (10 nM) selectively enhanced the frequency of glutamate-mediated spontaneous (sEPSCs) and miniature excitatory postsynaptic currents (mEPSCs) recorded from putative striatal medium spiny neurons. Capsaicin 51-60 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 18930149-5 2009 Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA). Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 130-135 18930149-7 2009 The effects of capsaicin and of PMA were absent after pharmacological or genetic inactivation of TRPV1 channels. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-102 19476209-5 2009 Remarkably, these aDRG NSCs expressed sensory neuronal markers vesicular glutamate transporter 2 (VGluT2--glutamate terminals), transient receptor potential vanilloid 1 (TrpV1--capsaicin sensitive), phosphorylated 200 kDa neurofilaments (pNF200--capsaicin insensitive, myelinated), and the serotonin transporter (5-HTT), which normally is transiently expressed in developing DRG. Capsaicin 177-186 transient receptor potential cation channel subfamily V member 1 Homo sapiens 170-175 19063991-1 2009 TRPV1 is a noxious heat, capsaicin (vanilloid) and acid receptor for which the development of antagonists represents a novel therapeutic approach for the treatment of pain. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 18769453-5 2009 Low-dose capsaicin stimulates cellular proliferation via TRPV1, whereas higher concentrations inhibit sebocyte growth and induce cell death independent of TRPV1. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 57-62 18528757-4 2008 Thus, the studies of the functional regulation of TRPV1 are mainly focused on two aspects: to develop more potent analogues of capsaicin with less side effects; or to elucidate the mechanisms of TRPV1 in pain sensitivity, especially of that TRPV1 as a target of various protein kinases such as PKD1 and Cdk5 is involved pain hypersensitivity. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 18806809-1 2008 The transient receptor potential vanilloid-1 (TRPV1) cation channel is a receptor that is activated by heat (>42 degrees C), acidosis (pH<6) and a variety of chemicals among which capsaicin is the best known. Capsaicin 186-195 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 18775990-1 2008 TRPV1 receptors are polymodal cation channels that open in response to diverse stimuli including noxious heat, capsaicin, and protons. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 18768735-1 2008 A remarkable new article in this issue of Molecular Pharmacology (p. 1261) shows that the capsaicin-sensitive ion channel TRPV1 is sensitized to activation by chemical and physical stimuli in the presence of inhaled general anesthetics. Capsaicin 90-99 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 18805596-1 2008 Agonists of the transient receptor potential vanilloid type 1 (TRPV1), such as capsaicin, cause pain and a drop in body temperature (hypothermia). Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-61 18805596-1 2008 Agonists of the transient receptor potential vanilloid type 1 (TRPV1), such as capsaicin, cause pain and a drop in body temperature (hypothermia). Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 18574245-8 2008 Simultaneous confocal imaging and electrophysiological recording of whole cells expressing a rapamycin-inducible lipid phosphatase also demonstrates that depletion of PI(4,5)P(2) inhibits capsaicin-activated TRPV1 current; the PI(4)P generated by the phosphatases was not sufficient to support TRPV1 function. Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 208-213 18574245-8 2008 Simultaneous confocal imaging and electrophysiological recording of whole cells expressing a rapamycin-inducible lipid phosphatase also demonstrates that depletion of PI(4,5)P(2) inhibits capsaicin-activated TRPV1 current; the PI(4)P generated by the phosphatases was not sufficient to support TRPV1 function. Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 294-299 18692962-7 2008 We conclude that CB2 agonists deserve imminent clinical trials for nociceptive, inflammatory and neuropathic chronic pain, in which capsaicin or heat-activated responses via TRPV1 may provide a clinical marker. Capsaicin 132-141 transient receptor potential cation channel subfamily V member 1 Homo sapiens 174-179 18559878-4 2008 Functional characterization of TRPV1 mutants showed that substitution of I696, W697, and R701 by alanine severely affected voltage- and heat-dependent activation and notably reduced the capsaicin responsiveness and tachyphylaxia, while mutation of K698, L699, and Q700 had minor effects. Capsaicin 186-195 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 18806809-1 2008 The transient receptor potential vanilloid-1 (TRPV1) cation channel is a receptor that is activated by heat (>42 degrees C), acidosis (pH<6) and a variety of chemicals among which capsaicin is the best known. Capsaicin 186-195 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-44 18709364-1 2008 Capsaicin activates the transient receptor potential vanilloid 1 receptor (TRPV1) on small sensory afferents, and capsaicin is commonly used to elucidate mechanisms of neuropathic pain. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-73 18709364-1 2008 Capsaicin activates the transient receptor potential vanilloid 1 receptor (TRPV1) on small sensory afferents, and capsaicin is commonly used to elucidate mechanisms of neuropathic pain. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 75-80 19085565-6 2008 However, both dexbrompheniramine and chlorpheniramine significantly inhibited capsaicin-evoked responses in hTRPV1-HEK. Capsaicin 78-87 transient receptor potential cation channel subfamily V member 1 Homo sapiens 108-114 18775990-3 2008 Using patch clamp photometry, we found that the fraction of the total current carried by Ca2+ (called the Pf%) was significantly smaller for TRPV1 currents evoked by protons than for those evoked by capsaicin. Capsaicin 199-208 transient receptor potential cation channel subfamily V member 1 Homo sapiens 141-146 18983665-1 2008 BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and itching sensation (TRPV1-4). Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-152 18983665-1 2008 BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and itching sensation (TRPV1-4). Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 18983665-1 2008 BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and itching sensation (TRPV1-4). Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 268-275 18983665-7 2008 The same qRT-PCR assay was used to compare TRPV1-4 expression between healthy controls and patients hyposensitive to capsaicin, pain and thermal stimuli: an almost doubled up-regulation of the TRPV1 gene was found in the pathological subjects. Capsaicin 117-126 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-50 18689441-5 2008 Clinically relevant concentrations of isoflurane, sevoflurane, enflurane, and desflurane sensitize TRPV1 to capsaicin and protons and reduce the threshold for heat activation. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 99-104 18809334-1 2008 Vanilloid agonists such as capsaicin activate ion flux through the TRPV1 channel, a heat- and ligand-gated cation channel that transduces painful chemical or thermal stimuli applied to peripheral nerve endings in skin or deep tissues. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 18809334-1 2008 Vanilloid agonists such as capsaicin activate ion flux through the TRPV1 channel, a heat- and ligand-gated cation channel that transduces painful chemical or thermal stimuli applied to peripheral nerve endings in skin or deep tissues. Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 18722778-2 2008 The tetrahydropyridine 6 is a novel TRPV1 receptor antagonist that potently inhibits receptor-mediated Ca2+ influx in vitro induced by several agonists, including capsaicin, N-arachidonoyldopamine (NADA), and low pH. Capsaicin 163-172 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-41 18553211-4 2008 Capsaicin evokes acute pain via activation of VR1 expressed in primary sensory neurons. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-49 18515644-4 2008 At the recombinant human TRPV1 receptor ABT-102 potently (IC(50) = 5-7 nM) inhibits agonist (capsaicin, N-arachidonyl dopamine, anandamide, and proton)-evoked increases in intracellular Ca(2+) levels. Capsaicin 93-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-30 18392614-3 2008 Although the seal resistance was quite low (approximately 7 Mohms) compared with the pipette patch-clamp gigaohm seal, the whole-cell channel current of the transient receptor potential vanilloid type 1 (TRPV1) channel expressing HEK293 cells was successfully observed, with a good signal-to-noise ratio, using capsaicin as a ligand molecule. Capsaicin 311-320 transient receptor potential cation channel subfamily V member 1 Homo sapiens 157-202 18392614-3 2008 Although the seal resistance was quite low (approximately 7 Mohms) compared with the pipette patch-clamp gigaohm seal, the whole-cell channel current of the transient receptor potential vanilloid type 1 (TRPV1) channel expressing HEK293 cells was successfully observed, with a good signal-to-noise ratio, using capsaicin as a ligand molecule. Capsaicin 311-320 transient receptor potential cation channel subfamily V member 1 Homo sapiens 204-209 18414789-3 2008 We studied the effects of Ara C on human dorsal root ganglion (DRG) neurons, especially the expression and sensitivity of the ion channel TRPV1, which responds to noxious heat and capsaicin and is a key mediator of neuropathic pain. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 138-143 18414789-9 2008 CONCLUSIONS: It is postulated that Ara C treatment blocked insertion of TRPV1 in the cell membrane, resulting in accumulation of the receptors in the cytoplasm, loss of capsaicin sensitivity, and membrane-bound immunostaining, which was restored with a rebound on withdrawal of Ara C. Capsaicin 169-178 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 18467913-1 2008 INTRODUCTION: Chemical stimulation with capsaicin in the intestinal lumen induces abdominal pain, presumably through a mechanism involving the polymodal vanilloid receptor TRPV1 (transient receptor potential vanilloid receptor subtype 1). Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 172-177 18541272-11 2008 Oral capsaicin significantly increases transient receptor potential vanilloid type-1 (TRPV1) channel expression as well as TRPV1 messenger ribonucleic acid (mRNA) in visceral adipose tissue. Capsaicin 5-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 39-84 18541272-11 2008 Oral capsaicin significantly increases transient receptor potential vanilloid type-1 (TRPV1) channel expression as well as TRPV1 messenger ribonucleic acid (mRNA) in visceral adipose tissue. Capsaicin 5-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 86-91 18495351-9 2008 In voltage-clamp experiments, 10 nM capsaicin evoked small inward currents in HEK293 cells expressing TRPV1 and ET(A). Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-107 18519133-0 2008 Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons. Capsaicin 85-94 transient receptor potential cation channel subfamily V member 1 Homo sapiens 54-59 18519133-4 2008 The activation of TRPV1 receptors with capsaicin (0.5-1.0 microM) increased the frequency of calcium transients (0.03+/-0.002 Hz vs. 0.05+/-0.006 Hz, P<0.05), mediated by AMPAergic transmission, as well as the percent of neurons with activity (37+/-3% vs. 65+/-4%, P<0.05). Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-23 18519133-6 2008 The effect of capsaicin was blocked by capsazepine (1 microM), TTX (100 nM) and KN-62 (1 microM), but not by K252a (200 nM) or PD98059 (50 microM) indicating the involvement of TRPV1. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 177-182 18364471-3 2008 Capsaicin (CAP; 0.04, 0.4, and 4 nM), a selective TRPV1 agonist, administered into the renal pelvis dose-dependently increased ARNA. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 18364471-3 2008 Capsaicin (CAP; 0.04, 0.4, and 4 nM), a selective TRPV1 agonist, administered into the renal pelvis dose-dependently increased ARNA. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 17826200-1 2008 The transient receptor potential vanilloid 1 or TRPV1 is a calcium-permeable ion channel that is activated by capsaicin, the active component of hot chilli peppers, and is involved in the development of inflammatory and neuropathic hyperalgesias. Capsaicin 110-119 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-53 17826200-4 2008 Calcium responses elicited by the TRPV1 agonist capsaicin were potentiated by treatment with ethanol, but morphine was not able to inhibit ethanol-sensitised capsaicin responses. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 17826200-7 2008 However, treatment with wortmannin at concentrations reported to cause PIP2 depletion limited the ability of ethanol to sensitise TRPV1-mediated capsaicin responses. Capsaicin 145-154 transient receptor potential cation channel subfamily V member 1 Homo sapiens 130-135 18325659-3 2008 Recent evidence shows that TRPV1 receptor stimulation by endocannabinoids or by capsaicin within the periaqueductal grey (PAG) leads to analgesia and this effect is associated with glutamate increase and the activation of OFF cell population in the rostral ventromedial medulla (RVM). Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 18242851-5 2008 Capsaicin treatment decreased TRPV1- and CGRP-positive neurons in L4 DRG of the treated side, but not the opposite side. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-35 18180272-1 2008 On the basis of the ability of capsaicin to activate the transient receptor potential vanilloid 1 receptor (TRPV1) expressed in nociceptive sensory neurons, topical and injectable high-concentration formulations are being developed as potential treatments for various pain syndromes. Capsaicin 31-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 57-106 18180272-1 2008 On the basis of the ability of capsaicin to activate the transient receptor potential vanilloid 1 receptor (TRPV1) expressed in nociceptive sensory neurons, topical and injectable high-concentration formulations are being developed as potential treatments for various pain syndromes. Capsaicin 31-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 108-113 18528787-7 2008 Calcium flowing through TRPV1 activates PLC and the resulting depletion of PIP2 was proposed to play a role in capsaicin-induced desensitization of these channels. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 17590514-2 2008 Although several studies in animals and humans have demonstrated that capsaicin (CAP), a TRPV1-specific agonist, and mustard oil (MO), a TRPA1 agonist, evoke responses that undergo functional cross-desensitization in various models, the mechanisms mediating this phenomenon are largely unknown. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 17590514-2 2008 Although several studies in animals and humans have demonstrated that capsaicin (CAP), a TRPV1-specific agonist, and mustard oil (MO), a TRPA1 agonist, evoke responses that undergo functional cross-desensitization in various models, the mechanisms mediating this phenomenon are largely unknown. Capsaicin 81-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 18230619-1 2008 Transient receptor potential V1 (TRPV1) is a nonselective cation channel expressed in nociceptors and activated by capsaicin. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-31 18230619-1 2008 Transient receptor potential V1 (TRPV1) is a nonselective cation channel expressed in nociceptors and activated by capsaicin. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 33-38 18230619-4 2008 In human embryonic kidney 293 cells expressing porcine TRPV1, low [Na(+)](o) evoked increases of [Ca(2+)](i) that were suppressed by TRPV1 antagonists and facilitated responses to capsaicin, protons, heat, and an endovanilloid. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 55-60 18242851-6 2008 These results suggest that local application of capsaicin onto the sciatic nerve can alleviate mechanical hyperalgesia, but not cold allodynia, in a peripheral neuropathic pain model and the pain alleviation may result from a decrease of TRPV1- and CGRP-positive sensory neurons of which fibers pass through the sciatic nerve. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 238-243 18481914-0 2008 Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin. Capsaicin 140-149 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 18183945-1 2008 Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Capsaicin 113-122 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-24 18267041-3 2008 The capsaicin and heat receptor TRPV1 is a key molecule in sensory nerves involved in peripheral nociception, but little is known regarding its role in the pregnant uterus. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 18172555-6 2008 Lidocaine sensitivity of TRPV1 required segments of the putative vanilloid-binding domain within and adjacent to transmembrane domain 3, was diminished under phosphatidylinositol 4,5-bisphosphate depletion, and was abrogated by a point mutation at residue R701 in the proximal C-terminal TRP domain. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-30 18218839-6 2008 In contrast, TRPV1 activation is prerequisite for the inhibition of Ca(V)2.3 calcium channels by capsaicin. Capsaicin 97-106 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 18852901-11 2008 CONCLUSION: TRPV1B expression, together with low TRPV1 expression, may explain the vanilloid paradox: even genuinely TRPV1 mRNA positive cells can be spared with therapeutic (up to micromolar) doses of RTX. Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 18155908-2 2008 Compound 1 has led to potent TRPV1 antagonistic benzamide derivatives ((+/-)-2: human IC(50)=23 nM, (+/-)-3: human IC(50)=14 nM in the capsaicin-induced calcium influx assay) containing indole and naphthyl moieties, obtained by elaboration of the tryptamine scaffold or via bioisosteric replacements. Capsaicin 135-144 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 18240098-0 2008 Adlea (ALGRX-4975), an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief. Capsaicin 34-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-50 18240098-1 2008 Anesiva Inc is developing Adlea (ALRGX-4975) - an injectable preparation of capsaicin, a TRPV1 (transient receptor potential vanilloid subfamily 1) receptor agonist - for the potential management of pain associated with osteoarthritis, tendonitiand postsurgical conditions, as well as for neuropathic pain occurring secondary to nerve injury. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 18199335-1 2008 Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1). Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 143-148 17728277-11 2008 Capsaicin, mustard oil, and cinnamaldehyde may induce heat hyperalgesia via enhanced thermal gating of TRPV1 that is coexpressed with TRPA1 in peripheral nociceptors. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 17913835-1 2007 The prototypical member of the vanilloid-responsive-like subfamily of transient receptor potential (TRP) channels is TRPV1. Capsaicin 31-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 117-122 17913835-9 2007 Incorporation of these changes into human TRPV1 gave rise to a channel with a normal EC(50) for capsaicin, but with a markedly elevated Hill slope such that the variant channel was hyporesponsive to capsaicin at low doses (<10 nM) and hyperresponsive at high doses (>10 nM). Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 17913835-9 2007 Incorporation of these changes into human TRPV1 gave rise to a channel with a normal EC(50) for capsaicin, but with a markedly elevated Hill slope such that the variant channel was hyporesponsive to capsaicin at low doses (<10 nM) and hyperresponsive at high doses (>10 nM). Capsaicin 199-208 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 18042138-0 2007 Modulation of intracellular calcium influences capsaicin-induced currents of TRPV-1 and voltage-activated channel currents in nociceptive neurones. Capsaicin 47-56 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-83 18042138-4 2007 The TRPV-1 receptor was activated by the application of 0.5 microM capsaicin, and the currents through TRPV-1 and VACC [I(TRPV-1) and I(Ca(V))] were measured either when Ca2+ release from intracellular stores was pharmacologically promoted or prevented. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-10 18042138-5 2007 With Ba2+ as the divalent charge carrier, capsaicin (0.5 microM) reduced I(Ca(V)) (elicited by a depolarization to 0 mV) to 52.7 +/- 4.5% of baseline, and the elicited current through the TRPV-1 receptor/channel complex was 6.6 +/- 0.9% [relative to peak I(Ca(V))]. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 188-194 18042138-7 2007 Increases of [Ca2+](i) by releasing Ca2+ from intracellular stores (using caffeine, 10 mM) before the application of capsaicin increased the I(TRPV-1) (14.1 +/- 7%), while the I(Ca(V)) was decreased to 51.6 +/- 4.9% compared with control. Capsaicin 117-126 transient receptor potential cation channel subfamily V member 1 Homo sapiens 143-149 17948977-7 2007 These models are consistent with the proposed binding modes and interactions of known activators of the TRPV1 channel such as capsaicin, in a structural model of the TM3/4 helical region of TRPV1. Capsaicin 126-135 transient receptor potential cation channel subfamily V member 1 Homo sapiens 104-109 17948977-7 2007 These models are consistent with the proposed binding modes and interactions of known activators of the TRPV1 channel such as capsaicin, in a structural model of the TM3/4 helical region of TRPV1. Capsaicin 126-135 transient receptor potential cation channel subfamily V member 1 Homo sapiens 190-195 17508360-5 2007 Capsaicin (CAP) (1-10 microM) increased nonselective cation channel whole cell currents (2.5-fold +/- 0.5-fold between -60 and 130 mV), resulting in calcium transients that were fully blocked by the TRPV1 antagonists capsazepine (CPZ) and ruthenium red, or removal of extracellular calcium. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 17508360-5 2007 Capsaicin (CAP) (1-10 microM) increased nonselective cation channel whole cell currents (2.5-fold +/- 0.5-fold between -60 and 130 mV), resulting in calcium transients that were fully blocked by the TRPV1 antagonists capsazepine (CPZ) and ruthenium red, or removal of extracellular calcium. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 18032651-2 2007 TRPV1, a pain receptor involved in nociception at the peripheral nerve terminals, can be activated by a range of physical and chemical stimuli (e.g., capsaicin, proton, and heat) and further sensitized by proinflammatory substances. Capsaicin 150-159 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 18001466-2 2007 TRPV1, the heat-, pH- and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released in response to noxious stimuli and during inflammation, is a potential target for the action of ET-1. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 18001466-6 2007 ET-1 strongly potentiated capsaicin-induced TRPV1 currents in some neurons, and in HEK293 cells co-expressing TRPV1 and the ETAR. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 44-49 18001466-6 2007 ET-1 strongly potentiated capsaicin-induced TRPV1 currents in some neurons, and in HEK293 cells co-expressing TRPV1 and the ETAR. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 18481914-3 2008 Depending on the vanilloid concentration and duration of exposure, the Ca2+ influx via TRPV1 desensitizes the channels themselves, which may represent not only a feedback mechanism protecting the cell from toxic Ca2+ overload, but also likely contributes to the analgesic effects of capsaicin. Capsaicin 17-26 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 18481914-3 2008 Depending on the vanilloid concentration and duration of exposure, the Ca2+ influx via TRPV1 desensitizes the channels themselves, which may represent not only a feedback mechanism protecting the cell from toxic Ca2+ overload, but also likely contributes to the analgesic effects of capsaicin. Capsaicin 283-292 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 18481914-4 2008 This review summarizes the current state of knowledge concerning the mechanisms that underlie the acute capsaicin-induced Ca2+-dependent desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 156-161 17508023-7 2007 Furthermore, direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased MMP-1 expression. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 17508023-7 2007 Furthermore, direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased MMP-1 expression. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 17850966-3 2007 The use of capsaicin for TRPV1 is an exemplary case for nociceptor studies. Capsaicin 11-20 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-30 17616464-4 2007 Three compounds showed partial TRPV1 agonism with EC(50) values in the low micromolar range and maximal efficacies between 25% and 55% of capsaicin. Capsaicin 138-147 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 17583335-3 2007 These compounds are potent antagonists of capsaicin activation of the TRPV1 receptor in vitro. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 17584831-3 2007 Here we show that TRPA1 is desensitized by homologous (mustard oil; a TRPA1 agonist) and heterologous (capsaicin; a TRPV1 agonist) agonists via Ca2+-independent and Ca2+-dependent pathways, respectively, in sensory neurons. Capsaicin 103-112 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-121 17442052-6 2007 Capsaicin, anandamide, resiniferatoxin and olvanil mediated increases in [Ca(2+)](i) were inhibited by the TRPV1 antagonists capsazepine and iodo-resiniferatoxin with potencies (K(B)) of approximately 70 nmol/L and 2 nmol/L, respectively. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 17442052-7 2007 Capsaicin stimulated the release of pre-labelled [(3)H]noradrenaline from monolayers of SH-SY5Y(hTRPV1) cells with an EC(50) of 0.6 nmol/L indicating amplification between [Ca(2+)](i) and release. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-102 17507218-2 2007 Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 17560936-6 2007 Stimulation of cultured OA- and RA-SF with the TRPV1 agonist capsaicin led to increased expression of IL-6 mRNA as well as of IL-6 protein in the cell culture supernatants. Capsaicin 61-70 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 17442041-0 2007 Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 59-64 17442041-1 2007 We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-90 17442041-1 2007 We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 92-97 17442041-1 2007 We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis. Capsaicin 150-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-90 17442041-1 2007 We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis. Capsaicin 150-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 92-97 17442041-9 2007 Finally, p38 but not extracellular signal-regulated protein kinase activation was required for TRPV1-mediated CPS-induced apoptosis of glioma cells. Capsaicin 110-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 95-100 17184838-0 2007 A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration. Capsaicin 20-29 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 17184838-4 2007 We show here that the capsaicin-sensitive transient receptor potential channel TRPV1, that plays an important role in pain transduction, is one of the Ca2+ influx channels involved in cell migration. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 79-84 17184838-5 2007 Activating TRPV1 channels with capsaicin leads to an acceleration of human hepatoblastoma (HepG2) cells pretreated with hepatocyte growth factor (HGF). Capsaicin 31-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 11-16 17184838-9 2007 The TRPV1 antagonist capsazepine prevents the stimulation of migration and inhibits capsaicin-sensitive currents. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 17184838-10 2007 Finally, we compared the contribution of capsaicin-sensitive TRPV1 channels to cell migration with that of mechanosensitive TRPV4 channels that are also expressed in HepG2 cells. Capsaicin 41-50 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 17184838-12 2007 In summary, we assigned a novel role to capsaicin-sensitive TRPV1 channels. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-65 17362879-1 2007 Capsaicin (Cap) and its analogs (CAPanalogs) have diverse effects in sensory neurons including analgesia, implying they modulate other cellular targets besides the TRPV1 Cap receptor. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 164-169 17582331-1 2007 TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and ligands such as capsaicin, leading to a burning pain sensation. Capsaicin 95-104 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17369424-1 2007 The transient receptor potential vanilloid 1 (TRPV1) channel is a nonselective cation channel activated by capsaicin and responsible for thermosensation. Capsaicin 107-116 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-44 17369424-1 2007 The transient receptor potential vanilloid 1 (TRPV1) channel is a nonselective cation channel activated by capsaicin and responsible for thermosensation. Capsaicin 107-116 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 18690026-2 2007 TRPV1, a channel responsible for the burning pain sensation in response to heat, acid or capsaicin, is desensitized at high intracellular calcium concentrations. Capsaicin 89-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17346705-4 2007 Capsaicin, activating TRPV1 receptors on small sensory afferents, induces enhanced cellular activity in dorsal horn neurons and produces a central mediated area of secondary hyperalgesia. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 17596456-4 2007 TRPV1 currents undergo desensitization on exposure to high concentrations of capsaicin in the presence of extracellular Ca2+. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17596456-5 2007 We show that in the presence of extracellular Ca2+, capsaicin activates phospholipase C (PLC) in TRPV1-expressing cells, inducing depletion of both PtdIns(4,5)P2 and its precursor PtdIns(4)P (PIP). Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-102 17392405-0 2007 Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. Capsaicin 116-125 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-79 17392405-0 2007 Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor. Capsaicin 116-125 transient receptor potential cation channel subfamily V member 1 Homo sapiens 80-85 17392405-1 2007 Vanilloid receptor-1 (TRPV1) is a nonselective cation channel, predominantly expressed by sensory neurons, which plays a key role in the detection of noxious painful stimuli such as capsaicin, acid, and heat. Capsaicin 182-191 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 17392405-4 2007 Using a Ca(2+)-based fluorometric imaging plate reader (FLIPR) assay, SB-705498 was shown to be a potent competitive antagonist of the capsaicin-mediated activation of the human TRPV1 receptor (pK(i) = 7.6) with activity at rat (pK(i) = 7.5) and guinea pig (pK(i) = 7.3) orthologs. Capsaicin 135-144 transient receptor potential cation channel subfamily V member 1 Homo sapiens 178-183 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 194-203 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-48 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 194-203 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 194-203 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-92 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 194-203 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-97 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 205-208 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-48 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 205-208 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 205-208 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-92 17917113-1 2007 Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases. Capsaicin 205-208 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-97 17274957-0 2007 Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 17274957-1 2007 TRPV1 is a non-selective cationic channel that is activated by capsaicin, acidic pH and thermal stimuli. Capsaicin 63-72 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17274957-3 2007 In this study, we investigated the mechanisms of capsaicin-induced cytotoxicity in HEK293 cells stably expressing TRPV1 with a focus on protein synthesis regulation and cytoskeleton reorganization. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 114-119 17274957-4 2007 Capsaicin inhibited protein synthesis in TRPV1-expressing HEK cells with an IC(50) of 15.6nM and depolymerized microtubules within 10min after exposure. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 17274957-6 2007 Protein synthesis inhibition induced by capsaicin was not a result of eIF2alpha hyperphosphorylation, but rather closely correlated with cytosolic calcium elevation caused by calcium flux through cell surface and intracellular TRPV1, and/or ER calcium depletion through intracellular TRPV1. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 284-289 17347480-11 2007 The reduced TRPV1 expression in visceral adipose tissue from obese humans was accompanied by reduced capsaicin-induced calcium influx. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 17306835-8 2007 Our findings suggest that topical application of capsaicin to the airway induces IL-6 production from respiratory epithelial cells via activation of TRPV1. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 149-154 17362879-1 2007 Capsaicin (Cap) and its analogs (CAPanalogs) have diverse effects in sensory neurons including analgesia, implying they modulate other cellular targets besides the TRPV1 Cap receptor. Capsaicin 0-3 transient receptor potential cation channel subfamily V member 1 Homo sapiens 164-169 17140857-1 2007 Previous studies have shown that heat stress possesses cardioprotection, which is related to the synthesis and release of calcitonin gene-related peptide (CGRP) via activation of capsaicin receptor (vanilloid receptor subtype 1, VR1) on the capsaicin-sensitive sensory neurons. Capsaicin 179-188 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-227 17287441-13 2007 We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 153-158 17287441-13 2007 We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins. Capsaicin 74-83 transient receptor potential cation channel subfamily V member 1 Homo sapiens 153-158 17140857-1 2007 Previous studies have shown that heat stress possesses cardioprotection, which is related to the synthesis and release of calcitonin gene-related peptide (CGRP) via activation of capsaicin receptor (vanilloid receptor subtype 1, VR1) on the capsaicin-sensitive sensory neurons. Capsaicin 179-188 transient receptor potential cation channel subfamily V member 1 Homo sapiens 229-232 17214968-5 2007 These data support the hypothesis that (E)-capsaicin, resiniferatoxin, capsazepine, and SB366791 are all mitochondrial inhibitors, able to activate apoptosis and/or necrosis via non-receptor mediated mechanisms, and also support the use of TRPV1 ligands as anti-cancer agents. Capsaicin 39-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 240-245 17295025-1 2007 Capsaicin, a pungent constituent from red chilli peppers, activates sensory nerve fibres via transient receptor potential vanilloid receptors type 1 (TRPV1) to release neuropeptides like calcitonin gene-related peptide (CGRP) and substance P. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 150-155 17068482-5 2007 Capsaicin, an activator of TRPV1, delayed barrier recovery, whereas capsazepin, an antagonist of TRPV1, blocked this delay. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 17298290-2 2007 TRPV1 is a non-selective cation channel gated by noxious heat, protons and capsaicin, thus being regarded as a polymodal molecular integrator in nociception. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17298290-4 2007 By activating multiple protein kinases to increase the phosphorylation of TRPV1, pronociceptive inflammatory mediators sensitise the TRPV1 response to noxious heat, protons and capsaicin, thus augmenting thermal hyperalgesia. Capsaicin 177-186 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 17298290-4 2007 By activating multiple protein kinases to increase the phosphorylation of TRPV1, pronociceptive inflammatory mediators sensitise the TRPV1 response to noxious heat, protons and capsaicin, thus augmenting thermal hyperalgesia. Capsaicin 177-186 transient receptor potential cation channel subfamily V member 1 Homo sapiens 133-138 16973931-5 2007 Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 16777226-1 2007 The vanilloid receptor family of cation channels includes the capsaicin-sensitive, proton- and heat-activated TRPV1 and noxious heat-activated TRPV2. Capsaicin 62-71 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 21204492-3 2007 TRPV1, the first member of the TRPV family and the sensory neuron receptor for vanilloid ligands like capsaicin, which is also responsive to noxious heat (>42 C), was found by expression cloning [4], as were the more distantly related epithelial Ca(2+) channels TRPV5 [5] and TRPV6 [6]. Capsaicin 102-111 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 16973931-5 2007 Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches. Capsaicin 107-116 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-68 16973931-5 2007 Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches. Capsaicin 107-116 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 16973931-5 2007 Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches. Capsaicin 107-116 transient receptor potential cation channel subfamily V member 1 Homo sapiens 298-303 17244257-2 2007 The VR1 modulatory drugs capsaicin, olvanil and capsazepine inhibited the binding of batrachotoxinin-A 20-alpha-benzoate ([(3)H]BTX-B) to receptor site 2 of voltage-gated sodium channels. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-7 17110039-1 2007 TRPV1 is a cation channel which is activated by temperature (> or =42 degrees C) and capsaicin. Capsaicin 88-97 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17110039-6 2007 These results suggest that the decreased expression of TRPV1 may be related to a functional knock out in capsaicin sensation and hypersensitivity to allicin in humans. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 55-60 17035013-0 2007 Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 16973931-5 2007 Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 298-303 17005903-8 2007 In whole-cell patch clamp studies, opioids significantly decreased capsaicin-induced TRPV1 currents in a naloxone- and pertussis toxinsensitive manner. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 85-90 16844842-1 2006 Transient receptor potential vanilloid type 1 (TRPV1) can be activated by multiple chemical and physical stimuli such as capsaicin, anandamide, protons, and heat. Capsaicin 121-130 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 16949718-3 2006 Furthermore, AEA binds to the transient receptor potential vanilloid type-1 (TRPV1), a capsaicin-sensitive, non-selective cation channel. Capsaicin 87-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-75 16949718-3 2006 Furthermore, AEA binds to the transient receptor potential vanilloid type-1 (TRPV1), a capsaicin-sensitive, non-selective cation channel. Capsaicin 87-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 17018028-0 2006 TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 17018028-8 2006 Moreover, when co-expressed with TRPV1, TRPV1b formed complexes with TRPV1, and inhibited TRPV1 channel function in response to capsaicin, acidic pH, heat and endogenous vanilloids, dose-dependently. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 33-38 17018028-8 2006 Moreover, when co-expressed with TRPV1, TRPV1b formed complexes with TRPV1, and inhibited TRPV1 channel function in response to capsaicin, acidic pH, heat and endogenous vanilloids, dose-dependently. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 17018028-8 2006 Moreover, when co-expressed with TRPV1, TRPV1b formed complexes with TRPV1, and inhibited TRPV1 channel function in response to capsaicin, acidic pH, heat and endogenous vanilloids, dose-dependently. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 16840565-4 2006 Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves. Capsaicin 11-20 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-105 16840565-4 2006 Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves. Capsaicin 11-20 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 16971522-1 2006 Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 16597917-3 2006 As shown by fura-2 ratio measurements while cells were incubated in a temperature-regulated chamber, significant [Ca(2+)](cyt) elevation was elicited by rapid changes in bath temperature, application of TRPV1 receptor agonists capsaicin and resiniferatoxin, or a cold receptor stimulator, icilin. Capsaicin 227-236 transient receptor potential cation channel subfamily V member 1 Homo sapiens 203-208 16962240-1 2007 Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 16908491-10 2006 These results suggest that TRPV1 serves as a receptor for both cyclohexanone and capsaicin in trigeminal nerve endings. Capsaicin 81-90 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 16840565-4 2006 Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves. Capsaicin 316-325 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-105 16840565-4 2006 Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves. Capsaicin 316-325 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-105 16844842-1 2006 Transient receptor potential vanilloid type 1 (TRPV1) can be activated by multiple chemical and physical stimuli such as capsaicin, anandamide, protons, and heat. Capsaicin 121-130 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 16844842-2 2006 Capsaicin interacts with the binding pocket constituted by transmembrane regions 3 and 4, whereas protons act through residues in the prepore loop of TRPV1. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 150-155 16844842-4 2006 A rabbit anti-rat TRPV1 polyclonal antibody (Ab-156H) acted as a full antagonist of proton activation (IC(50) values for pH 5 and 5.5 were 364.68 +/- 29.78 and 28.31 +/- 6.30 nM, respectively) and as a partial antagonist of capsaicin, heat, and pH 6 potentiated chemical ligand (anandamide and capsaicin) activation (50-79% inhibition). Capsaicin 224-233 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-23 16844842-4 2006 A rabbit anti-rat TRPV1 polyclonal antibody (Ab-156H) acted as a full antagonist of proton activation (IC(50) values for pH 5 and 5.5 were 364.68 +/- 29.78 and 28.31 +/- 6.30 nM, respectively) and as a partial antagonist of capsaicin, heat, and pH 6 potentiated chemical ligand (anandamide and capsaicin) activation (50-79% inhibition). Capsaicin 294-303 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-23 17153968-1 2006 Transient receptor potential vanilloid (TRPV1), representing ion channel family, is activated in human and animal organism by capsaicin and some other factors such as heat, acidosis, and ion dysbalance. Capsaicin 126-135 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 16849427-3 2006 We tested the hypothesis that certain cannabinoids directly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizing transient receptor potential vanilloid 1 (TRPV1) via a calcium calcineurin-dependent mechanism. Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 158-198 16627674-3 2006 Irritant agents, including capsaicin, resiniferatoxin, and citric acid, elicit cough in humans and in experimental animals through the activation of the transient receptor potential vanilloid 1 (TRPV1). Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 153-193 16627674-3 2006 Irritant agents, including capsaicin, resiniferatoxin, and citric acid, elicit cough in humans and in experimental animals through the activation of the transient receptor potential vanilloid 1 (TRPV1). Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 195-200 16793902-2 2006 PAR2-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (TRPV1), which is gated by capsaicin, protons and noxious heat. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-111 16793902-2 2006 PAR2-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (TRPV1), which is gated by capsaicin, protons and noxious heat. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 113-118 16793902-7 2006 PAR2 agonists enhanced capsaicin-stimulated increases in [Ca2+]i and whole-cell currents in HEK 293 cells, indicating TRPV1 sensitization. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-123 16842630-0 2006 The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 16842630-2 2006 Several receptors including G-protein coupled prostaglandin receptors have been reported to functionally interact with the TRPV1 through a cAMP-dependent protein kinase A (PKA) pathway to potentiate TRPV1-mediated capsaicin responses. Capsaicin 214-223 transient receptor potential cation channel subfamily V member 1 Homo sapiens 123-128 16842630-2 2006 Several receptors including G-protein coupled prostaglandin receptors have been reported to functionally interact with the TRPV1 through a cAMP-dependent protein kinase A (PKA) pathway to potentiate TRPV1-mediated capsaicin responses. Capsaicin 214-223 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 16842630-6 2006 HEK293 cells were stably transfected with TRPV1 and MOP, and calcium (Ca2+) responses to injection of the TRPV1 agonist capsaicin were monitored in Fluo-3-loaded cells. Capsaicin 120-129 transient receptor potential cation channel subfamily V member 1 Homo sapiens 106-111 16849427-3 2006 We tested the hypothesis that certain cannabinoids directly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizing transient receptor potential vanilloid 1 (TRPV1) via a calcium calcineurin-dependent mechanism. Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 200-205 16849427-7 2006 The WIN-induced desensitization of TRPV1 was mediated by calcineurin, because the application of structurally distinct calcineurin antagonists (calcineurin autoinhibitory peptide and cyclosporine/cyclophilin complex) abolished WIN-induced inhibition of capsaicin-evoked inward currents and neuropeptide exocytosis. Capsaicin 253-262 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-40 18615146-2 2006 The heat- and capsaicin-gated channel TRPV1, which is an important detector of multiple noxious stimuli, plays a critical role in the development of thermal hyperalgesia induced by a wide range of inflammatory mediators. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 38-43 16741069-0 2006 Endothelin-1 potentiates capsaicin-induced TRPV1 currents via the endothelin A receptor. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-48 16721555-1 2006 The transient receptor potential vanilloid subfamily 1 (TRPV1) is an ion channel activated by capsaicin, heat, protons and endogenous ligands such as anandamide. Capsaicin 94-103 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-54 16721555-1 2006 The transient receptor potential vanilloid subfamily 1 (TRPV1) is an ion channel activated by capsaicin, heat, protons and endogenous ligands such as anandamide. Capsaicin 94-103 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 16763024-10 2006 Capsaicin-sensitive TRPV1 vanilloid receptors were not upregulated. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 16580202-3 2006 Pharmacological studies using electrophysiological and FLIPR-Ca2+-based assays showed that compounds such as 8 and 15 were potent antagonists versus the multiple chemical and physical modes of TRPV1 activation (namely capsaicin, acid and noxious heat). Capsaicin 218-227 transient receptor potential cation channel subfamily V member 1 Homo sapiens 193-198 16792172-10 2006 These results suggest that capsaicin can directly influence the epithelial secretory and various functions via TRPV1 as well as the activation of the sensory neurons. Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 111-116 16741069-3 2006 TRPV1, the heat-, proton-, and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released by painful stimuli and during inflammation, is a potential target for the action of ET-1. Capsaicin 31-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 16741069-6 2006 In whole-cell patch clamp recordings of HEK293 cells co-expressing TRPV1-YFP and the ET(A) receptor, capsaicin (10 nM) elicited small currents, which were markedly potentiated when capsaicin (10 nM) and ET-1 (100 nM) were applied simultaneously. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 16630076-6 2006 Fibroblasts treated with capsaicin, an agonist to the VR1, induced significant changes of the membrane current and the intracellular calcium level, and these changes were antagonized by capsazepin. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 54-57 16630609-1 2006 The transient receptor potential vanilloid 1 (TRPV1) receptor is a ligand-gated cation channel that can be activated by capsaicin, heat, protons and cytosolic lipids. Capsaicin 120-129 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-44 16630609-1 2006 The transient receptor potential vanilloid 1 (TRPV1) receptor is a ligand-gated cation channel that can be activated by capsaicin, heat, protons and cytosolic lipids. Capsaicin 120-129 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 16213723-1 2006 Intracellular photolysis of a novel "caged" capsaicin analogue results in in vitro activation of the capsaicin receptor TRPV1. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 120-125 16510717-5 2006 When expressed heterologously, FAF1 reduces the responses of TRPV1 to capsaicin, acid, and heat, to the pharmacological level of native capsaicin receptor in sensory neurons. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 16542883-4 2006 The function of these chemoceptive afferents can selectively be manipulated and explored with the use of capsaicin which acts via a cation channel termed TRPV1. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 154-159 16464449-2 2006 TRPV1 is activated by noxious temperature, low extracellular pH and diverse lipid derivatives, and is uniquely sensitive to vanilloid molecules, including capsaicin. Capsaicin 124-133 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 16464449-2 2006 TRPV1 is activated by noxious temperature, low extracellular pH and diverse lipid derivatives, and is uniquely sensitive to vanilloid molecules, including capsaicin. Capsaicin 155-164 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 16407761-4 2006 Single-cell reverse-transcription polymerase chain reaction revealed the expression of TRPV1 only in capsaicin-sensitive neurons. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 16288992-5 2005 The various TRPV1 agonists activated pTRPV1 in a dose-dependent manner in the order of potency of resiniferatoxin (RTX) > olvanil > capsaicin > phorbol 12-phenylacetate 13-acetate 20-homovanillate (PPAHV), phorbol 12,13-dinonanoate 20-homovanillate (PDNHV). Capsaicin 138-147 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 16288992-9 2005 TRPV1 antagonists, iodoRTX, ruthenium red and capsazepine suppressed capsaicin-induced responses. Capsaicin 69-78 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 transient receptor potential cation channel subfamily V member 1 Homo sapiens 80-83 16218380-3 2005 Recent advance, especially the identification of TRPV1 receptor (for which capsaicin, protons and heat are ligands), P2X and P2Y receptor (for which ATP is a ligand) and acid sensing ion channel made a remarkable progress in understanding the mechanism of nociceptive neurons. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 16140298-5 2005 In contrast, capsaicin evoked a sustained increase in [Ca(2+)] and large inwards currents in sensory neurons and TRPV1-expressing HEK293 cells. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 113-118 15997233-8 2005 The TRPV1 agonists capsaicin, olvanil and arvanil all induced concentration-dependent increases in skin blood flow and burning pain when administered dermally. Capsaicin 19-28 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 transient receptor potential cation channel subfamily V member 1 Homo sapiens 80-83 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 transient receptor potential cation channel subfamily V member 1 Homo sapiens 233-236 15967874-1 2005 At submicromolar concentrations, capsaicin specifically activates the TRPV1 receptor involved in nociception. Capsaicin 33-42 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 16100528-3 2005 2 In this study, switching the equivalent residue in the human TRPV1 (which has some significant differences with the rat TRPV1) also rendered this channel relatively insensitive to activation by capsaicin and proved critical in determining the receptor"s sensitivity to the putative endovanilloid N-arachidonoyl-dopamine (NADA), suggesting a similar mode of activation for these two agonists. Capsaicin 196-205 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 16043235-3 2005 A recent study shows that piperine, the irritant principle in black pepper, is more efficient than capsaicin in the desensitization of human TRPV1, which suggests that this pharmacological aspect of vanilloids can be dissociated from its potency. Capsaicin 99-108 transient receptor potential cation channel subfamily V member 1 Homo sapiens 141-146 15936040-1 2005 After 7 years from its cloning, the transient receptor potential vanilloid type-1 (TRPV1) channel remains the sole membrane receptor mediating the pharmacological effects of the hot chilli pepper pungent component, capsaicin, and of the Euphorbia toxin, resiniferatoxin. Capsaicin 215-224 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-81 15936040-1 2005 After 7 years from its cloning, the transient receptor potential vanilloid type-1 (TRPV1) channel remains the sole membrane receptor mediating the pharmacological effects of the hot chilli pepper pungent component, capsaicin, and of the Euphorbia toxin, resiniferatoxin. Capsaicin 215-224 transient receptor potential cation channel subfamily V member 1 Homo sapiens 83-88 16123700-2 2005 As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation. Capsaicin 134-143 transient receptor potential cation channel subfamily V member 1 Homo sapiens 233-236 15837819-1 2005 The vanilloid receptor transient receptor potential type V1 (TRPV1) integrates responses to multiple stimuli, such as capsaicin, acid, heat, and endovanilloids and plays an important role in the transmission of inflammatory pain. Capsaicin 118-127 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 15837819-3 2005 A-425619 was found to potently block capsaicin-evoked increases in intracellular calcium concentrations in HEK293 cells expressing recombinant human TRPV1 receptors (IC50 = 5 nM). Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 149-154 15722382-1 2005 BACKGROUND: TRPV1 is a ligand-gated ion channel whose activation by capsaicin increases intracellular Ca(2+) ([Ca(2+)](i)). Capsaicin 68-77 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-17 16118913-1 2005 OBJECTIVE: Capsaicin, which acts by binding to the vanilloid receptor-1 (VR1), has been shown to give protection against gastric mucosal injury and to enhance healing of gastric ulcers. Capsaicin 11-20 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-71 16118913-1 2005 OBJECTIVE: Capsaicin, which acts by binding to the vanilloid receptor-1 (VR1), has been shown to give protection against gastric mucosal injury and to enhance healing of gastric ulcers. Capsaicin 11-20 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-76 15883036-1 2005 The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-27 15883036-1 2005 The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 15883036-1 2005 The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel. Capsaicin 54-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-27 15883036-1 2005 The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel. Capsaicin 54-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 15913603-5 2005 Addition of capsaicin, (R)-methanandamide and resiniferatoxin to prostate cells induced a dose-dependent increase in the intracellular calcium concentration that was reversed by the vanilloid TRPV1 receptor antagonist capsazepine. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 192-197 15722382-14 2005 Whilst capsaicin activated TRPV1 and Delta(9)-tetrahydrocannabinol activated CB(1), anandamide is an endogenous agonist for both receptor systems. Capsaicin 7-16 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 15691846-2 2005 TRPV1 exhibits desensitization in a Ca2+-dependent manner upon repeated activation by capsaicin or protons. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 15918513-1 2005 A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-25 15918513-1 2005 A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 15918513-1 2005 A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants. Capsaicin 111-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-25 15918513-1 2005 A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants. Capsaicin 111-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 15793280-1 2005 The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-24 15793280-1 2005 The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-29 15793280-1 2005 The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 85-90 15793280-6 2005 In organ culture, TRPV1 activation by capsaicin resulted in a dose-dependent and TRPV1-specific inhibition of hair shaft elongation, suppression of proliferation, induction of apoptosis, premature HF regression (catagen), and up-regulation of intrafollicular transforming growth factor-beta(2). Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-23 15793280-6 2005 In organ culture, TRPV1 activation by capsaicin resulted in a dose-dependent and TRPV1-specific inhibition of hair shaft elongation, suppression of proliferation, induction of apoptosis, premature HF regression (catagen), and up-regulation of intrafollicular transforming growth factor-beta(2). Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 81-86 15915217-3 2005 The TRPV1 channel can be activated by vanilloids such as capsaicin, as well as endogenous stimulators including H(+), heat, lipoxygenase products and anandamide. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 15764707-0 2005 A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 15615864-4 2005 AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 83-88 15615864-4 2005 AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 15615864-4 2005 AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 15644492-6 2005 By probing human and rat brain cDNA libraries to identify TRPV subunits, we identified a novel human TRPV1 RNA splice variant, TRPV1b, which forms functional ion channels that are activated by temperature (threshold, approximately 47 degrees C), but not by capsaicin or protons. Capsaicin 257-266 transient receptor potential cation channel subfamily V member 1 Homo sapiens 101-106 15764707-4 2005 In these cells, capsaicin and anandamide induced Ca(2+) influx mediated by TRPV1. Capsaicin 16-25 transient receptor potential cation channel subfamily V member 1 Homo sapiens 75-80 15715923-2 2005 The TRPV1 channel, a member of the TRPV sub-family, is identified by expression cloning using the "hot" pepper-derived vanilloid compound capsaicin as a ligand. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 15715923-2 2005 The TRPV1 channel, a member of the TRPV sub-family, is identified by expression cloning using the "hot" pepper-derived vanilloid compound capsaicin as a ligand. Capsaicin 138-147 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 15715923-6 2005 Regarding the latter, these neurons release stored neuropeptides through a calcium-dependent mechanism via the binding of capsaicin to VR1. Capsaicin 122-131 transient receptor potential cation channel subfamily V member 1 Homo sapiens 135-138 16173059-3 2005 TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin. Capsaicin 197-206 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 15689158-1 2005 Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores were synthesized, and their in vitro activity in blocking capsaicin activation of TRPV1 was assessed. Capsaicin 186-195 transient receptor potential cation channel subfamily V member 1 Homo sapiens 6-46 15689158-1 2005 Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores were synthesized, and their in vitro activity in blocking capsaicin activation of TRPV1 was assessed. Capsaicin 186-195 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-53 15689158-1 2005 Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores were synthesized, and their in vitro activity in blocking capsaicin activation of TRPV1 was assessed. Capsaicin 186-195 transient receptor potential cation channel subfamily V member 1 Homo sapiens 210-215 16173059-1 2005 Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro-inflammatory cytokine production and cell death. Capsaicin 85-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-36 16173059-1 2005 Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro-inflammatory cytokine production and cell death. Capsaicin 85-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 38-41 16173059-1 2005 Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro-inflammatory cytokine production and cell death. Capsaicin 85-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-50 15548432-7 2004 The effects of capsaicin, a specific agonist for TRPV1 receptors, were inhibited by capsazepine, but only weakly by CB1 or CB2 receptor antagonists. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 15447941-1 2004 Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway wall. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 15447941-1 2004 Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway wall. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-48 15447941-2 2004 We determined the expression of TRPV-1 in the airways of patients with chronic persistent cough of diverse causes and with an enhanced capsaicin cough response. Capsaicin 135-144 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-38 15447941-5 2004 There was a significant correlation between capsaicin tussive response and the number of TRPV-1-positive nerves within the patients with cough. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-95 15579007-3 2004 Small molecule agonists of VR1, including capsaicin and RTX, are currently utilized for a number of clinical syndromes, including intractable neuropathic pain, spinal detrusor hyperreflexia, and bladder hypersensitivity; however, antagonists of VR1 have yet to reach the clinic. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-30 15464036-3 2004 The ensuing research established that the neuropharmacological properties of capsaicin are due to its activation of the transient receptor potential ion channel of the vanilloid type 1 (TRPV1). Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 186-191 15548449-11 2004 CONCLUSION: The present findings provide the evidence of the presence of TRPV1 on normal human urothelium where it could have important implications in the mechanism of action of intravesical vanilloids (capsaicin and resiniferatoxin). Capsaicin 204-213 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 15464274-1 2004 TRPV1, a receptor for capsaicin, plays a key role in mediating thermal and inflammatory pain. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 15464028-3 2004 The present review concentrates on the effects of capsaicin--through the transient receptor potential vanilloid receptor type 1 (TRPV1) receptor--on innervated gastrointestinal, respiratory and genitourinary smooth muscle preparations. Capsaicin 50-59 transient receptor potential cation channel subfamily V member 1 Homo sapiens 129-134 15152028-1 2004 Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)]. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 86-114 15152028-1 2004 Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)]. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-119 15152028-1 2004 Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)]. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 135-180 15152028-1 2004 Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)]. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 182-187 15363396-7 2004 Determinants of icilin sensitivity map to a region of TRPM8 that corresponds to the capsaicin binding site on the noxious heat receptor TRPV1, suggesting a conserved molecular logic for gating of these thermosensitive channels by chemical agonists. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 136-141 15464036-4 2004 Expressed by primary afferent neurons innervating the gut and other organs, TRPV1 is gated not only by vanilloids such as capsaicin, but also by noxious heat, acidosis and intracellular lipid mediators such as anandamide and lipoxygenase products. Capsaicin 122-131 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 15128843-4 2004 In human embryonic kidney 293 cells expressing TRPV1 and PAR2, PAR2 agonists increased capsaicin- or proton-evoked TRPV1 currents through a PKC-dependent pathway. Capsaicin 87-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 14996838-1 2004 Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine, and products of lipoxygenase). Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 14996838-1 2004 Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine, and products of lipoxygenase). Capsaicin 126-135 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 14996838-1 2004 Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine, and products of lipoxygenase). Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 14996838-2 2004 Only limited information is available in TRPV1 on the residues that contribute to vanilloid activation. Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 14996838-6 2004 Here we identify key residues (Met(547) and Thr(550)) in transmembrane regions 3 and 4 (TM3/4) of rat and human TRPV1 that confer vanilloid sensitivity, [(3)H]RTX binding and competitive antagonist binding to rabbit TRPV1. Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 14996838-9 2004 Based on our data we propose a model of the TM3/4 region of TRPV1 bound to capsaicin or RTX that may aid in the development of potent TRPV1 antagonists with utility in the treatment of sensory disorders. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-65 14996838-9 2004 Based on our data we propose a model of the TM3/4 region of TRPV1 bound to capsaicin or RTX that may aid in the development of potent TRPV1 antagonists with utility in the treatment of sensory disorders. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-139 15289293-2 2004 Two unsaturated members of this family of lipids, N-arachidonoyl-dopamine (NADA) and N-oleoyl-dopamine, were shown to potently activate the transient receptor potential channel type V1 (TRPV1), also known as the vanilloid receptor type 1 for capsaicin. Capsaicin 242-251 transient receptor potential cation channel subfamily V member 1 Homo sapiens 186-191 15311065-1 2004 PURPOSE: Overactive bladder symptoms due to various etiologies have been successfully treated with capsaicin by desensitization of the temperature sensitive vanilloid receptor TRPV1. Capsaicin 99-108 transient receptor potential cation channel subfamily V member 1 Homo sapiens 176-181 15351928-4 2004 The sensitizing effect of fenoterol was inhibited by high concentration of capsaicin (10 microM, 30 min before fenoterol sensitization), which induces depletion of mediators from sensory nerves, or co-incubation of fenoterol and capsazepine (1 microM), a vanilloid TRPV-1 receptor antagonist. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 265-271 15306801-5 2004 The chemical agonists menthol (TRPM8) and capsaicin (TRPV1) function as gating modifiers, shifting activation curves towards physiological membrane potentials. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 15288402-5 2004 In vivo behavioral studies demonstrate that intraplantar injection of 20.0 but not 2.0 microM octreotide (OCT, SSTR agonist) significantly reduces capsaicin (CAP, a ligand for TRPV1) -induced flinching and lifting/licking behaviors. Capsaicin 147-156 transient receptor potential cation channel subfamily V member 1 Homo sapiens 176-181 15203132-3 2004 Pharmacological studies using electrophysiological and FLIPR Ca(2+) based assays showed compound 5 was an antagonist versus capsaicin, noxious heat and acid mediated activation of TRPV1. Capsaicin 124-133 transient receptor potential cation channel subfamily V member 1 Homo sapiens 180-185 15175387-2 2004 Five of them can alternatively be activated by nonthermal stimuli such as capsaicin [transient receptor potential vanilloid 1 (TRPV1)] or hypo-osmolarity (TRPV2 and TRPV4). Capsaicin 74-83 transient receptor potential cation channel subfamily V member 1 Homo sapiens 85-125 15175387-2 2004 Five of them can alternatively be activated by nonthermal stimuli such as capsaicin [transient receptor potential vanilloid 1 (TRPV1)] or hypo-osmolarity (TRPV2 and TRPV4). Capsaicin 74-83 transient receptor potential cation channel subfamily V member 1 Homo sapiens 127-132 15152030-4 2004 VR1 agonist capsaicin (CAP; 100 nm) reversibly increased EPSC frequency, effects blocked by capsazepine. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-3 15152030-4 2004 VR1 agonist capsaicin (CAP; 100 nm) reversibly increased EPSC frequency, effects blocked by capsazepine. Capsaicin 23-26 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-3 15128292-5 2004 As a result, the molecular determinants that endow TRPV1 with its physiological properties, namely activation by heat, potentiation by extracellular acidic pH, and interaction with vanilloid-like compounds, as well as its permeation properties are being unveiled. Capsaicin 181-190 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 15128293-2 2004 Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein, a nonselective cation channel that belongs to the large family of TRP ion channels, and is activated by the pungent ingredient of hot chilli peppers, capsaicin. Capsaicin 269-278 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-101 15128293-2 2004 Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein, a nonselective cation channel that belongs to the large family of TRP ion channels, and is activated by the pungent ingredient of hot chilli peppers, capsaicin. Capsaicin 269-278 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 14960593-1 2004 The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-29 14960593-1 2004 The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 33-38 15128843-4 2004 In human embryonic kidney 293 cells expressing TRPV1 and PAR2, PAR2 agonists increased capsaicin- or proton-evoked TRPV1 currents through a PKC-dependent pathway. Capsaicin 87-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-120 15128844-2 2004 We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated by capsaicin, protons, and noxious heat, mediates PAR2-induced hyperalgesia. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-71 15128844-2 2004 We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated by capsaicin, protons, and noxious heat, mediates PAR2-induced hyperalgesia. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 15128844-4 2004 PAR2 agonists increased intracellular [Ca2+] ([Ca2+]i) in these neurons in culture, and PAR2-responsive neurons also responded to the TRPV1 agonist capsaicin, confirming coexpression of PAR2 and TRPV1. Capsaicin 148-157 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-139 15128844-5 2004 PAR2 agonists potentiated capsaicin-induced increases in [Ca2+]i in TRPV1-transfected human embryonic kidney (HEK) cells and DRG neurons and potentiated capsaicin-induced currents in DRG neurons. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-73 15128844-9 2004 Coinjection of nonhyperalgesic doses of PAR2 agonist and capsaicin induced hyperalgesia that was inhibited by deletion of TRPV1 or antagonism of PKC. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 15071115-12 2004 Increasing the concentrations of capsaicin reversed the inhibitory response to capsaicin, suggesting a competitive inhibition at TRPV1. Capsaicin 33-42 transient receptor potential cation channel subfamily V member 1 Homo sapiens 129-134 15071115-12 2004 Increasing the concentrations of capsaicin reversed the inhibitory response to capsaicin, suggesting a competitive inhibition at TRPV1. Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 129-134 15071115-13 2004 Finally, exposure of HEK/TRPV1 cells to capsaicin induced an approximately 2.4-fold increase in proapoptotic cells that was abolished by adenosine analogs. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-30 15283452-5 2004 TRPV1 and ANKTM1 are mediating the pungency of nociceptor-specific chemicals such as capsaicin or mustard oil. Capsaicin 85-94 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 14657192-5 2004 The reasons for investigating its effects on capsaicin-activated TRPV1 channels are to understand how it may modulate this channel that is involved in pain, inflammation, and gustatory physiology. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 65-70 14657192-8 2004 Nicotine also modulates TRPV1 receptors inducing a several-fold increase in capsaicin-activated currents in both TG neurons and in cells with heterologously expressed TRPV1 receptors. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 14657192-8 2004 Nicotine also modulates TRPV1 receptors inducing a several-fold increase in capsaicin-activated currents in both TG neurons and in cells with heterologously expressed TRPV1 receptors. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 167-172 14657192-11 2004 In this regard, its effect on TRPV1 receptors differs from those of ethanol that has been shown to increase the capsaicin-activated current but decrease the threshold temperature. Capsaicin 112-121 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-35 15016092-6 2004 Consistent with the involvement of TRPV1, these proton-evoked currents were blocked by capsazepine and were only found in neurons that responded to capsaicin with an increase in membrane conductance. Capsaicin 148-157 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-40 14699077-0 2004 Ca2+/calmodulin modulates TRPV1 activation by capsaicin. Capsaicin 46-55 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-31 14699077-1 2004 TRPV1 ion channels mediate the response to painful heat, extracellular acidosis, and capsaicin, the pungent extract from plants in the Capsicum family (hot chili peppers) (Szallasi, A., and P.M. Blumberg. Capsaicin 85-94 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 14699077-11 2004 The convergence of these stimuli on TRPV1 channels expressed in peripheral sensory nerves underlies the common perceptual experience of pain due to hot temperatures, tissue damage and exposure to capsaicin. Capsaicin 196-205 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-41 14987622-3 2004 The vanilloid receptor VR1 (TRPV1) is expressed by nociceptors, and is triggered by capsaicin, noxious heat, protons, and chemicals produced during inflammation. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-26 14987622-3 2004 The vanilloid receptor VR1 (TRPV1) is expressed by nociceptors, and is triggered by capsaicin, noxious heat, protons, and chemicals produced during inflammation. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-33 15046718-2 2004 The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 14987252-1 2004 The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes in vitro and in vivo. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-32 14987252-1 2004 The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes in vitro and in vivo. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-37 14987252-1 2004 The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes in vitro and in vivo. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 14987252-6 2004 In pruritic skin of PN, VR1 expression was highly increased in epidermal keratinocytes and nerve fibers, which was normalized after capsaicin application. Capsaicin 132-141 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-27 14630912-3 2004 Here we show that VR1 must be phosphorylated by Ca2+-calmodulin dependent kinase II (CaMKII) before its activation by capsaicin. Capsaicin 118-127 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-21 14654105-1 2004 Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in the detection of noxious painful stimuli, such as capsaicin, acid and heat. Capsaicin 207-216 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 14654105-6 2004 In electrophysiological experiments, SB-366791 was demonstrated to be an effective antagonist of hTRPV1 when activated by different modalities, such as capsaicin, acid or noxious heat (50 degrees C). Capsaicin 152-161 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-103 14506258-0 2003 Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway. Capsaicin 19-28 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 14581201-0 2003 Thermodynamics of heat activation of single capsaicin ion channels VR1. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-70 14534154-0 2003 Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation. Capsaicin 142-151 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-31 12926020-7 2003 The vanilloid receptor (VR1) is a nonselective cation channel that is activated by capsaicin, acid, and temperature. Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-27 14534154-1 2003 Capsaicin, the active substance in chilli peppers, activates the vanilloid type 1 receptor (VR1) rather than the vanilloid-like receptor (VRL1) in the trigeminal ganglion and nucleus of small and medium C- and Adelta-fibres. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 92-95 14534154-2 2003 Capsaicin induces calcitonin gene-related peptide (CGRP) release when VR1 receptors are activated, and this can be reversed by both the VR1 receptor antagonist capsazepine and the CGRP blocker alphaCGRP8-37 in vitro. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-73 14534154-2 2003 Capsaicin induces calcitonin gene-related peptide (CGRP) release when VR1 receptors are activated, and this can be reversed by both the VR1 receptor antagonist capsazepine and the CGRP blocker alphaCGRP8-37 in vitro. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 136-139 14550768-1 2003 Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-39 14550768-7 2003 These results imply that capsaicin induces mitochondrial dysfunction in VR1-expressing cells, leading to apoptotic cell death, which is a well-known neurotoxic effect of capsaicin. Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-75 14550768-1 2003 Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-68 14550768-4 2003 Here we report that capsaicin induces cell death in VR1-expressing sensory neurons and VR1-transfected human embryonic kidney cells. Capsaicin 20-29 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-55 14550768-4 2003 Here we report that capsaicin induces cell death in VR1-expressing sensory neurons and VR1-transfected human embryonic kidney cells. Capsaicin 20-29 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-90 14550768-7 2003 These results imply that capsaicin induces mitochondrial dysfunction in VR1-expressing cells, leading to apoptotic cell death, which is a well-known neurotoxic effect of capsaicin. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-75 12608892-2 2003 Stimulation of TRPV1-expressing cells, but not control Sf 9 cells, with resiniferatoxin (RTX), capsaicin or anandamide, produced an increase in cytosolic free Ca(2+) concentration ([Ca(2+)](i)), with EC(50) values of 166 pM, 24.5 nM and 3.89 microM respectively. Capsaicin 95-104 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 12886029-1 2003 The vanilloid receptor 1 (VR1) is a heat-activated cation channel which also responds to capsaicin and other chemical stimuli. Capsaicin 89-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-29 12886029-2 2003 Protein kinase C has a stimulatory effect on VR1 activity, either alone or after activation with capsaicin. Capsaicin 97-106 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-48 12886029-5 2003 Capsaicin activated the VR1 channel and increased the intracellular calcium concentration. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-27 14520770-1 2003 AIMS: To investigate the levels of the capsaicin or vanilloid receptor-1 (VR1) and the ATP-gated purinoceptor P2X3 in painful and nonpainful human tooth pulps. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-77 12760991-1 2003 UNLABELLED: Capsaicin, acting at the vanilloid 1 receptor (VR1), may potentiate local anesthetic activity, and as a ligand-gated ion channel of the transient receptor potential family, may also be a target for IV general anesthetics. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 59-62 12760991-9 2003 IMPLICATIONS: Vanilloid receptors (VR1) are activated by capsaicin, the pain-producing component of hot chili peppers. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-38 12823468-0 2003 Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro. Capsaicin 47-56 transient receptor potential cation channel subfamily V member 1 Homo sapiens 145-165 12812762-0 2003 A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents. Capsaicin 114-123 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 12802203-1 2003 The vanilloid receptor TRPV1 is a ligand-gated cation channel that can be activated by capsaicin, acids and noxious heat. Capsaicin 87-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-28 12802203-2 2003 For vanilloids, a stretch of approximately 8 amino acids in the vicinity of the TM3 region on the cytosolic side of TRPV1 and R114 and E761 in the N- and C-cytosolic tails, respectively, has been shown to be critical for capsaicin binding and channel activation. Capsaicin 221-230 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-121 12922928-0 2003 Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists. Capsaicin 18-27 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-67 12922928-12 2003 Using human recombinant TRPV1, 6-iodo-nordihydrocapsaicin (IC(50)=10 nM against 100 nM capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine, and was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 12922928-12 2003 Using human recombinant TRPV1, 6-iodo-nordihydrocapsaicin (IC(50)=10 nM against 100 nM capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine, and was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 153-158 12922928-12 2003 Using human recombinant TRPV1, 6-iodo-nordihydrocapsaicin (IC(50)=10 nM against 100 nM capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine, and was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 153-158 12808128-2 2003 Extracellular Ca2+-dependent desensitization of TRPV1 observed in patch-clamp experiments when using both heterologous expression systems and native sensory ganglia is thought to be one mechanism underlying the paradoxical effectiveness of capsaicin as an analgesic therapy. Capsaicin 240-249 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-53 12692270-3 2003 VR-1 is a non-selective ion channel, found on sensory neurons, that primarily fluxes Ca(2+) ions in response to various stimuli, including physiologically acidic conditions, heat greater than 45 degrees C and noxious compounds such as capsaicin. Capsaicin 235-244 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-4 12692270-4 2003 Using an in vitro neuronal model to study HSV-1 latency and reactivation, we found that agonists of the VR-1 channel - capsaicin and heat - resulted in reactivation of latent HSV-1. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 104-108 12719786-6 2003 AEA-induced EC death was inhibited by a selective vanilloid receptor 1 (VR1) antagonist, capsazepine, and was enhanced by a VR1 agonist, capsaicin, indicating that AEA induces apoptosis in ECs via VR1. Capsaicin 137-146 transient receptor potential cation channel subfamily V member 1 Homo sapiens 124-127 12721390-7 2003 Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure. Capsaicin 124-133 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-21 12721390-10 2003 Surprisingly, the cytotoxic effects of capsaicin in TRPV1 overexpressing cells were also not inhibited by TRPV1 antagonists or by treatments that modified extracellular calcium. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 12721390-11 2003 Thus, capsaicin interacted with TRPV1 expressed by BEAS-2B and other airway epithelial cells to cause the calcium-dependent production of cytokines and, conversely, calcium-independent cell death. Capsaicin 6-15 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 12721390-13 2003 The mechanisms of these cellular responses to capsaicinoids appear to proceed via distinct cellular pathways, but both pathways are initiated by TRPV1. Capsaicin 46-59 transient receptor potential cation channel subfamily V member 1 Homo sapiens 145-150 12569099-7 2003 These findings demonstrate the existence of an endogenous compound in the brain that is similar to capsaicin and NADA in its chemical structure and activity on VR1. Capsaicin 99-108 transient receptor potential cation channel subfamily V member 1 Homo sapiens 160-163 12719786-6 2003 AEA-induced EC death was inhibited by a selective vanilloid receptor 1 (VR1) antagonist, capsazepine, and was enhanced by a VR1 agonist, capsaicin, indicating that AEA induces apoptosis in ECs via VR1. Capsaicin 137-146 transient receptor potential cation channel subfamily V member 1 Homo sapiens 124-127 12642400-5 2003 (3) We have demonstrated that I-RTX inhibited capsaicin-induced mobilization of intracellular Ca(2+) in rat trigeminal neurons (IC(50) 0.87 nM) and in HEK293 cells transfected with the human TRPV1 (IC(50) 0.071 nM). Capsaicin 46-55 transient receptor potential cation channel subfamily V member 1 Homo sapiens 191-196 12522087-9 2003 We conclude that VR1 is able to couple to Ca2+ mobilization by a Ca2+ dependent mechanism, mediated by capsaicin and RTX, and a Ca2+ independent mechanism mediated by RTX alone. Capsaicin 103-112 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-20 12522087-1 2003 1 Capsaicin and resiniferatoxin (RTX) stimulate Ca2+ influx by activating vanilloid receptor 1 (VR1), a ligand-gated Ca2+ channel on sensory neurones. Capsaicin 2-11 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-94 12522087-1 2003 1 Capsaicin and resiniferatoxin (RTX) stimulate Ca2+ influx by activating vanilloid receptor 1 (VR1), a ligand-gated Ca2+ channel on sensory neurones. Capsaicin 2-11 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-99 11931994-4 2002 However, VR1 remains the only channel activated by vanilloids such as capsaicin. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 9-12 12490594-3 2003 The recently cloned vanilloid receptor-1 (VR1) is a polymodal receptor, responding to thermal, pH, or vanilloids such as capsaicin stimulation. Capsaicin 121-130 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-40 12490594-3 2003 The recently cloned vanilloid receptor-1 (VR1) is a polymodal receptor, responding to thermal, pH, or vanilloids such as capsaicin stimulation. Capsaicin 121-130 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-45 12490594-6 2003 Consistent with neuronal VR1, activation of epidermal VR1 by capsaicin induced a calcium influx. Capsaicin 61-70 transient receptor potential cation channel subfamily V member 1 Homo sapiens 54-57 12490594-7 2003 Treating HaCaT cells with capsaicin resulted in a dose-dependent expression of cyclooxygenase-2 (COX-2), whereas pretreatment with the VR1 receptor antagonist capsazepine abolished the capsaicin-stimulated increase in COX-2 expression. Capsaicin 185-194 transient receptor potential cation channel subfamily V member 1 Homo sapiens 135-138 12490594-9 2003 Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2, and the stimulated release was attenuated by capsazepine. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-31 12098622-0 2002 Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes. Capsaicin 55-64 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-51 11992116-1 2002 The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for the burning sensation elicited by capsaicin. Capsaicin 117-126 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-24 11992116-1 2002 The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for the burning sensation elicited by capsaicin. Capsaicin 117-126 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-29 11992116-5 2002 Ethanol potentiated the response of VR1 to capsaicin, protons and heat and lowered the threshold for heat activation of VR1 from approximately 42 degrees C to approximately 34 degrees C. This provides a likely mechanistic explanation for the ethanol-induced sensory responses that occur at body temperature and for the sensitivity of inflamed tissues to ethanol, such as might be found in esophagitis, neuralgia or wounds. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-39 12054538-3 2002 Further analysis revealed that thapsigargin is a mixed-type inhibitor, suggesting both direct and indirect interactions between thapsigargin and the capsaicin binding site of VR1. Capsaicin 149-158 transient receptor potential cation channel subfamily V member 1 Homo sapiens 175-178 12007523-1 2002 Very recently, a membrane receptor (vanilloid receptor type 1 [VR-1]) sensitive to capsaicin or resiniferatoxin (RTX) was identified in small- and medium-sized dorsal root ganglion neurons that give rise to most unmyelinated sensory fibers. Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-67 12007523-2 2002 After vanilloid binding to VR-1, these neurons remain transiently desensitized; that is, less reactive to natural stimuli. Capsaicin 6-15 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-31 11829471-1 2002 Vanilloid receptor subtype 1, VR1, is an ion channel that serves as a polymodal detector of pain-producing chemicals such as capsaicin and protons in primary afferent neurons. Capsaicin 125-134 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-28 11829471-1 2002 Vanilloid receptor subtype 1, VR1, is an ion channel that serves as a polymodal detector of pain-producing chemicals such as capsaicin and protons in primary afferent neurons. Capsaicin 125-134 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-33 11829471-3 2002 The capsaicin- and acidification-evoked increases in [Ca(2+)](i) were inhibited by capsazepine, an antagonist to VR1. Capsaicin 4-13 transient receptor potential cation channel subfamily V member 1 Homo sapiens 113-116 11829471-5 2002 These findings suggest that functional VR1-like protein is present and functions as a sensor against noxious chemical stimuli, such as capsaicin or acidification, in epidermal keratinocytes. Capsaicin 135-144 transient receptor potential cation channel subfamily V member 1 Homo sapiens 39-42 14599363-3 2002 HEK-293 cells, stably expressing rVR1 or hVR1, exhibited dose-dependent increases in [Ca(++)](i) when challenged with capsaicin (EC(50)s congruent with 10 nM). Capsaicin 118-127 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-45 14599363-4 2002 Responses to capsaicin were blocked by the VR1 antagonist capsazepine and were dependent on VR1 expression. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-46 14599363-4 2002 Responses to capsaicin were blocked by the VR1 antagonist capsazepine and were dependent on VR1 expression. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 92-95 12270633-2 2002 The VR1 receptor is activated not only by capsaicin but also by noxious heat and protons, and therefore it is suggested as a molecular integrator of chemical and physical stimuli that elicit pain. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-7 12270633-6 2002 Around 10% of the VR1 receptor-ir is expressed on neurons that contain CGRP-ir (ten among 74) in the human TG, indicating that capsaicin may act through the VR1 receptor to modulate the release of CGRP and in turn to modulate pain. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-21 12270633-6 2002 Around 10% of the VR1 receptor-ir is expressed on neurons that contain CGRP-ir (ten among 74) in the human TG, indicating that capsaicin may act through the VR1 receptor to modulate the release of CGRP and in turn to modulate pain. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 157-160 12243775-3 2002 Capsaicin produced a concentration-dependent increase in intracellular calcium in guinea pig VR1-CHO cells with an estimated EC(50) of 0.17 +/- 0.0065 micro M, similar to that previously reported for rat and human VR1. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 214-217 12166946-2 2002 Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety. Capsaicin 180-193 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-51 12166946-2 2002 Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety. Capsaicin 180-193 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-56 12570018-8 2002 PEA enhances the VR1-mediated effects of AEA and capsaicin on calcium influx into cells. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-20 12160748-7 2002 Animals expressing the mammalian TRPV1 (VR1) channel in ASH nociceptor neurons avoid the TRPV1 ligand capsaicin, allowing selective, drug-inducible activation of a specific behavior. Capsaicin 102-111 transient receptor potential cation channel subfamily V member 1 Homo sapiens 33-38 12160748-7 2002 Animals expressing the mammalian TRPV1 (VR1) channel in ASH nociceptor neurons avoid the TRPV1 ligand capsaicin, allowing selective, drug-inducible activation of a specific behavior. Capsaicin 102-111 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-43 12160748-7 2002 Animals expressing the mammalian TRPV1 (VR1) channel in ASH nociceptor neurons avoid the TRPV1 ligand capsaicin, allowing selective, drug-inducible activation of a specific behavior. Capsaicin 102-111 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 12077604-2 2002 Mammalian TRP channels that are gated by heat and capsaicin (>43 degrees C; TRPV1 (ref. Capsaicin 50-59 transient receptor potential cation channel subfamily V member 1 Homo sapiens 79-84 12077606-1 2002 Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-20 12077606-1 2002 Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-25 12077606-1 2002 Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 12077606-1 2002 Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Capsaicin 227-236 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-20 12077606-1 2002 Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Capsaicin 227-236 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-25 12077606-1 2002 Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin. Capsaicin 227-236 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 12077606-2 2002 Although VR1 gene disruption results in a loss of capsaicin responses, it has minimal effects on thermal nociception. Capsaicin 50-59 transient receptor potential cation channel subfamily V member 1 Homo sapiens 9-12 12109845-10 2002 The expression of VR1 is plastic and down-regulated during vanilloid therapy, which might have a pivotal role in desensitization. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-21 12091579-2 2002 It has been suggested that the capsaicin receptor (VR1), a nociceptor-specific cation channel sensitive to noxious heat, protons, and capsaicin, is a channel that is modified by BK in these effects. Capsaicin 31-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-54 12060783-0 2002 An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 93-96 12060783-2 2002 VR1 is gated by protons, heat, and the pungent ingredient of "hot" chili peppers, capsaicin. Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-3 12060783-10 2002 Our data demonstrate the existence of a brain substance similar to capsaicin not only with respect to its chemical structure but also to its potency at VR1 receptors. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 152-155 11752091-6 2002 The data demonstrate that VR1 receptor agonists capsaicin and resiniferatoxin lead to a sustained increase in intracellular calcium and sodium in a concentration-dependent manner, followed by cell death. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-29 11698030-5 2001 In agreement with these findings, neonatal capsaicin treatment that induces degeneration of capsaicin-sensitive, vanilloid VR1 receptor-expressing, thin, unmyelinated, nociceptive primary afferent fibres significantly reduced the cannabinoid CB(1) receptor immunostaining in the superficial spinal dorsal horn. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 123-126 12031340-1 2002 The vanilloid receptor subtype 1 (VR1) is expressed in a sub-population of small dorsal root ganglion (DRG) neurones in mammals and serves as the common transducer of the pain-producing signals, such as noxious heat, acids and capsaicin [Caterina et al., Nature 389 (1997) 816-824; Tominaga et al., Neuron 21 (1998) 531-543]. Capsaicin 227-236 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-32 12031340-1 2002 The vanilloid receptor subtype 1 (VR1) is expressed in a sub-population of small dorsal root ganglion (DRG) neurones in mammals and serves as the common transducer of the pain-producing signals, such as noxious heat, acids and capsaicin [Caterina et al., Nature 389 (1997) 816-824; Tominaga et al., Neuron 21 (1998) 531-543]. Capsaicin 227-236 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-37 11685701-0 2001 Novel capsaicin (VR1) and purinergic (P2X3) receptors in Hirschsprung"s intestine. Capsaicin 6-15 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-20 11698030-5 2001 In agreement with these findings, neonatal capsaicin treatment that induces degeneration of capsaicin-sensitive, vanilloid VR1 receptor-expressing, thin, unmyelinated, nociceptive primary afferent fibres significantly reduced the cannabinoid CB(1) receptor immunostaining in the superficial spinal dorsal horn. Capsaicin 92-101 transient receptor potential cation channel subfamily V member 1 Homo sapiens 123-126 11358970-1 2001 Vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that can be activated by capsaicin and other vanilloids as well as by protons and heat. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-28 11483711-0 2001 Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-76 11333266-2 2001 VR1, which binds and is activated by capsaicin and other vanilloid compounds, was noted to interact with the endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic acid in a pH-dependent manner. Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-3 11333266-2 2001 VR1, which binds and is activated by capsaicin and other vanilloid compounds, was noted to interact with the endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic acid in a pH-dependent manner. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-3 11358970-1 2001 Vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that can be activated by capsaicin and other vanilloids as well as by protons and heat. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-33 11404433-1 2001 The recently cloned vanilloid receptor (VR1) is postulated to account for heat and capsaicin sensitivity in unmyelinated afferents. Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-43 11431028-2 2001 Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Capsaicin 69-78 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-120 19003326-2 2001 There was an increase in permeability at high concentration (200 to 500 muM) of capsaicin, and the effect was inhibited by pretreatment of capsazepine, which is a competitive antagonist of the vanilloid receptor 1 (VR1). Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 193-213 19003326-2 2001 There was an increase in permeability at high concentration (200 to 500 muM) of capsaicin, and the effect was inhibited by pretreatment of capsazepine, which is a competitive antagonist of the vanilloid receptor 1 (VR1). Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 215-218 19003326-5 2001 Our results showed that the permeability increase by capsaicin was through binding to VR1-like protein of Caco-2 cells. Capsaicin 53-62 transient receptor potential cation channel subfamily V member 1 Homo sapiens 86-89 11413249-1 2001 The endogenous cannabinoid receptor ligand, anandamide (AEA), is a full agonist of the vanilloid receptor type 1 (VR1) for capsaicin. Capsaicin 123-132 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-117 11243859-1 2001 The irritant action of capsaicin is mediated by the vanilloid receptor, VR1, which is expressed in sensory neurons termed nociceptors. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-75 11124944-4 2001 Within seconds of vanilloid exposure, the intracellular free calcium ([Ca(2+)](i)) was elevated in cells expressing VR1. Capsaicin 18-27 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-119 11226139-2 2001 Both rat and human VR1 formed ligand gated channels that were activated by capsaicin with similar EC(50) values. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-22 11226139-8 2001 Capsazepine and ruthenium red were both more potent at blocking the capsaicin response of human VR1 than rat VR1. Capsaicin 68-77 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-99 11243859-6 2001 Capsaicin (EC(50) = 853 nM), low pH (<5.5), and noxious heat (44 degrees C) activate hVR1 expressed in Xenopus oocytes. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-92 11243859-7 2001 Subthreshold pH (6.4) sensitizes VR1 to capsaicin (EC(50) = 221 nM). Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 33-36 11050376-4 2000 Mammalian cells transfected with human VR1 respond to capsaicin with an increase in intracellular calcium. Capsaicin 54-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 39-42 11166956-1 2001 Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-45 11166956-1 2001 Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-50 11166956-1 2001 Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property. Capsaicin 91-94 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-45 11166956-1 2001 Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property. Capsaicin 91-94 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-50 11102645-1 2000 The vanilloid receptor 1 (VR1) gene is responsible for both capsaicin-, and low threshold (LT) noxious heat-sensitivity in mammalian primary sensory neurons. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-24 11102645-1 2000 The vanilloid receptor 1 (VR1) gene is responsible for both capsaicin-, and low threshold (LT) noxious heat-sensitivity in mammalian primary sensory neurons. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-29 11102645-8 2000 These findings suggest that a VR1 homologue which lacks to sequence for capsaicin-sensitivity is possibly the LT noxious heat transducer in chicken. Capsaicin 72-81 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-33 11140687-1 2000 The cloned (VR1) and native VRs are non-selective cation channels directly activated by harmful heat, extracellular protons and vanilloid compounds. Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-15 11587243-2 2001 These neurons carry receptors that bind capsaicin, recently identified as the vanilloid VR1 receptor. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-91 11587243-12 2001 The discovery of VR1-expressing cells in the brain as well as in non-neural tissues such as the kidney and urothelium places VR1 in a much broader perspective than peripheral pain perception, and is hoped to identify further, yet unsuspected, indications for vanilloid therapy. Capsaicin 259-268 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-20 11587243-13 2001 The realisation that VR1 and cannabinoid CB1 receptors have overlapping ligand recognition properties may also have far-reaching implications for vanilloid therapy. Capsaicin 146-155 transient receptor potential cation channel subfamily V member 1 Homo sapiens 21-24 11166474-2 2001 Capsaicin sensitivity co-localizes with the expression of a cloned capsaicin receptor, vanilloid receptor type 1 (VR-1), which displays properties similar to the native capsaicin response. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-118 11166474-2 2001 Capsaicin sensitivity co-localizes with the expression of a cloned capsaicin receptor, vanilloid receptor type 1 (VR-1), which displays properties similar to the native capsaicin response. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-118 11166474-3 2001 To determine whether VR-1 mRNA levels are regulated by NGF, VR-1 mRNA levels and the ability to respond to capsaicin by release of the neuropeptide calcitonin gene related peptide (CGRP) were measured as a function of NGF concentration in cultures of adult dorsal root ganglion neurons. Capsaicin 107-116 transient receptor potential cation channel subfamily V member 1 Homo sapiens 21-25 10859346-2 2000 The response of VR1 to capsaicin or noxious heat is dynamically potentiated by extracellular protons within a pH range encountered during tissue acidosis, such as that associated with arthritis, infarction, tumor growth, and other forms of injury. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-19 10903936-1 2000 BACKGROUND: Vanilloids, such as capsaicin and resiniferatoxin (RTX), are recognized at the cell surface by vanilloid receptor type 1 (VR1), which has recently been cloned. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-137 10903936-2 2000 VR1 mediates the effects of capsaicin and RTX in VR1-expressing cells, but vanilloids can induce apoptosis through a pathway not mediated by VR1. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-3 10903936-2 2000 VR1 mediates the effects of capsaicin and RTX in VR1-expressing cells, but vanilloids can induce apoptosis through a pathway not mediated by VR1. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-52 10903936-2 2000 VR1 mediates the effects of capsaicin and RTX in VR1-expressing cells, but vanilloids can induce apoptosis through a pathway not mediated by VR1. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-52 10462546-5 1999 The typical vanilloid agonists olvanil and capsaicin inhibited [(3)H]RTX binding to HEK293/VR1 cells with K(i) values of 0.4 and 4.0 microM, respectively. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 91-94 10644739-2 2000 Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to encode an ion channel that is activated by both capsaicin, the pain producing compound in chili peppers, and by noxious thermal stimuli. Capsaicin 133-142 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-56 10694225-2 2000 Further electrophysiological studies showed that anandamide (10 or 100 microM) and capsaicin (1 microM) produced similar inward currents in hVR1 transfected, but not in parental, HEK293 cells. Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 140-144 10694225-4 2000 In the FLIPR anandamide and capsaicin were full agonists at hVR1, with pEC(50) values of 5. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-64 10462546-5 1999 The typical vanilloid agonists olvanil and capsaicin inhibited [(3)H]RTX binding to HEK293/VR1 cells with K(i) values of 0.4 and 4.0 microM, respectively. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 91-94 10462546-9 1999 RTX and capsaicin induced calcium mobilization in HEK293/VR1 cells with EC(50) values of 4.1 and 82 nM, respectively. Capsaicin 8-17 transient receptor potential cation channel subfamily V member 1 Homo sapiens 57-60 10496326-2 1999 Heat and protons as well as capsaicin activate VR1 to induce the influx of cations, particularly Ca2+ and Na+ ions. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-50 33766560-8 2021 The I703A mutant of TRPV1 showed increased sensitivity to capsaicin, as expected when removing the effect of an endogenous competitive antagonist. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 10361881-7 1999 Recently, the receptor for capsaicin (the vanilloid receptor 1: VR1) has been cloned, identified and characterized. Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 64-67 9655678-4 1998 However, this method has recently been called into question by research demonstrating that the molecular target of capsaicin on spinal and trigeminal afferents, vanilloid receptor subtype 1 (VR1), is absent from vagal afferents. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 161-189 9655678-4 1998 However, this method has recently been called into question by research demonstrating that the molecular target of capsaicin on spinal and trigeminal afferents, vanilloid receptor subtype 1 (VR1), is absent from vagal afferents. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 191-194 17038971-2 1998 It is no coincidence that during the same period the capsaicin receptor was cloned and named the vanilloid receptor subtype 1 and the European dual centre study of intravesical capsaicin reported that overall 80% of patients derived some clinical benefit. Capsaicin 53-62 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-125 17038971-3 1998 In spite of this, ultrapotent capsaicin analogues such as resiniferatoxin, which also interact with the vanilloid receptor subtype 1, are being studied. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 104-132 33766560-1 2021 Regulation of the heat- and capsaicin-activated Transient Receptor Potential Vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-88 33766560-1 2021 Regulation of the heat- and capsaicin-activated Transient Receptor Potential Vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 90-95 33766560-2 2021 In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinositides were proposed to act as competitive vanilloid antagonists. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-24 33766560-2 2021 In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinositides were proposed to act as competitive vanilloid antagonists. Capsaicin 187-196 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-24 33799960-0 2021 Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia: A Proof-of-Concept Study. Capsaicin 72-81 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 33799960-8 2021 Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 +- 0.32 swallows/min vs post-capsaicin: 0.81 +- 0.51 swallow/min; p = 0.0003). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-73 33799960-8 2021 Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 +- 0.32 swallows/min vs post-capsaicin: 0.81 +- 0.51 swallow/min; p = 0.0003). Capsaicin 125-134 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-73 33799960-8 2021 Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 +- 0.32 swallows/min vs post-capsaicin: 0.81 +- 0.51 swallow/min; p = 0.0003). Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-73 33591238-8 2021 Capsaicin, the agonist of transient receptor potential vanilloid type 1 (TRPV1), could selectively activate TRPV1, inducing Ca2+ influx and related signaling pathways. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-71 33591238-8 2021 Capsaicin, the agonist of transient receptor potential vanilloid type 1 (TRPV1), could selectively activate TRPV1, inducing Ca2+ influx and related signaling pathways. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 33591238-8 2021 Capsaicin, the agonist of transient receptor potential vanilloid type 1 (TRPV1), could selectively activate TRPV1, inducing Ca2+ influx and related signaling pathways. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 108-113 33803867-5 2021 The effect on sperm migration on a 10 muM capsaicin gradient (CPS), a TRPV1 agonist, was then investigated. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 34171094-2 2021 Capsaicin (Caps), an exogenous agonist of the vanilloid receptor of transient potential type 1 (TRPV1), has shown promising results in the treatment of obesity. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-101 25848051-5 2015 Capsaicin activated the chloride currents in an extracellular calcium-dependent manner in HEK293T cells expressing TRPV1 and ANO1. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-120 34465184-8 2021 CRITICAL ISSUES: TRPV1 channels are activated by both capsaicin and cisplatin, which produce differential effects on the inner ear. Capsaicin 54-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 34465184-10 2021 In contrast, activation of TRPV1 by capsaicin protected against subsequent hearing loss induced by cisplatin. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 34899333-5 2021 Low pH (pH 6) activates TRPV1, a polymodal ion channel also activated by heat, capsaicin and hyperosmolar conditions. Capsaicin 79-88 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 34171094-2 2021 Capsaicin (Caps), an exogenous agonist of the vanilloid receptor of transient potential type 1 (TRPV1), has shown promising results in the treatment of obesity. Capsaicin 11-15 transient receptor potential cation channel subfamily V member 1 Homo sapiens 96-101 34364049-1 2021 Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high permeability to Ca2+, which can be activated by low pH, noxious heat and vanilloid compounds such as capsaicin. Capsaicin 194-203 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 34724681-3 2021 Although capsaicin-induced TRPV1 and Ca2+/calpain-dependent ablation of axonal terminals is necessary for long-lasting analgesia, the mechanisms underlying capsaicin-induced ablation of axonal terminals and its association with analgesia are not fully understood. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 34672430-8 2022 CONCLUSIONS: The present study demonstrated for the first time, that SPE inhibited capsaicin-induced Ca2+ influx with binding to TRPV1 in HEL293VR11 cells. Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 129-134 34657531-4 2021 In this review, the modulating effects of capsaicin on glucose homeostasis in cell models, animal models and human trials are summarized through both TRPV1 dependent and TRPV1 independent pathways. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 150-155 34657531-4 2021 In this review, the modulating effects of capsaicin on glucose homeostasis in cell models, animal models and human trials are summarized through both TRPV1 dependent and TRPV1 independent pathways. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 170-175 34364049-1 2021 Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high permeability to Ca2+, which can be activated by low pH, noxious heat and vanilloid compounds such as capsaicin. Capsaicin 194-203 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 34533076-3 2021 Transient Receptor Potential Vanilloid 1 (TRPV1) is an ion channel involving in the cytotoxicity of capsaicin. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 34533076-3 2021 Transient Receptor Potential Vanilloid 1 (TRPV1) is an ion channel involving in the cytotoxicity of capsaicin. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 34273488-3 2021 Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki(CAP) = 2.6 and 6.9 nM, respectively. Capsaicin 78-87 transient receptor potential cation channel subfamily V member 1 Homo sapiens 92-98 34353899-4 2021 We show that CaV2.2 channels in TRPV1-nociceptor endings are activated by capsaicin-induced depolarization and contribute to increased intracellular calcium. Capsaicin 74-83 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 34504955-1 2021 Both a silent resident phosphatidylinositol lipid and a "hot" vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 230-235 34332978-1 2021 Transient Receptor Potential vanilloid 1 (TRPV1) ion channel serves as the detector for noxious temperature above 42 C, pungent chemicals like capsaicin and acidic extracellular pH. Capsaicin 143-152 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 34302514-9 2021 8% capsaicin ablation predominantly defunctionalizes TRPV1+-expressing cutaneous nociceptors responsible for heat pain transduction, suggesting that sensitization of these fibers is required for development of heat hyperalgesia following cutaneous UVB-induced inflammation but they are likely only partially necessary for the establishment of robust primary mechanical hyperalgesia. Capsaicin 3-12 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-58 34332978-1 2021 Transient Receptor Potential vanilloid 1 (TRPV1) ion channel serves as the detector for noxious temperature above 42 C, pungent chemicals like capsaicin and acidic extracellular pH. Capsaicin 143-152 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 34332978-5 2021 We found that these endocannabinoid ligands bind to the vanilloid binding pocket of TRPV1 in the "tail-up, head-down" configuration, similar to capsaicin; however, there is a unique interaction with TRPV1 Y512 residue critical for endocannabinoid activation of TRPV1 channels. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 84-89 34332978-5 2021 We found that these endocannabinoid ligands bind to the vanilloid binding pocket of TRPV1 in the "tail-up, head-down" configuration, similar to capsaicin; however, there is a unique interaction with TRPV1 Y512 residue critical for endocannabinoid activation of TRPV1 channels. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 34332978-6 2021 These data suggest a differential structural mechanism is involved in TRPV1 activation by endocannabinoids compared to the classic agonist capsaicin. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 34127538-7 2021 Multiparametric analysis of our results shed light on the capability of calmodulin inhibitors included in the Prestwick library to inhibit TRPV1 activation by Capsaicin (CAPS). Capsaicin 159-168 transient receptor potential cation channel subfamily V member 1 Homo sapiens 139-144 34127538-7 2021 Multiparametric analysis of our results shed light on the capability of calmodulin inhibitors included in the Prestwick library to inhibit TRPV1 activation by Capsaicin (CAPS). Capsaicin 170-174 transient receptor potential cation channel subfamily V member 1 Homo sapiens 139-144 34445178-6 2021 TRPV1 became immobile after capsaicin stimulation, followed by its gradual endocytosis. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 34282193-4 2021 Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (hiPSC-CM) from 4 healthy donors were incubated with lipopolysaccharides (LPS, 6 h), TRPV1 agonist capsaicin (CAP, 20 min) or the antagonist capsazepine (CPZ, 20 min). Capsaicin 165-174 transient receptor potential cation channel subfamily V member 1 Homo sapiens 151-156 34421629-6 2021 Results: Capsaicin induced increase in cough sensitivity by upregulating the protein level of TRPV1, leading to the secretions of Substance P and neurokinin A which stimulated neurogenic inflammation. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 34442487-9 2021 However, in printed neurons, we found compromised neurite outgrowth and lower sensitivity to the ligand of the TRPV1 channel, capsaicin. Capsaicin 126-135 transient receptor potential cation channel subfamily V member 1 Homo sapiens 111-116 34289785-12 2021 In addition to the analgesic effect, TRPV1 agonist-Capsaicin possesses a disease-modifying effect in CIPN through its restorative property in damaged sensory nerves. Capsaicin 51-60 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 34239123-0 2021 Heat-dependent opening of TRPV1 in the presence of capsaicin. Capsaicin 51-60 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-31 34239123-1 2021 Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation channel that serves as the primary heat and capsaicin sensor in humans. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-47 34239123-1 2021 Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation channel that serves as the primary heat and capsaicin sensor in humans. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 35247474-9 2022 In addition, the intracellular Ca2+ concentration of 16HBE cells pretreated with MXGSD medicated serum was also tested after stimulation with the TRPV1 agonist capsaicin. Capsaicin 160-169 transient receptor potential cation channel subfamily V member 1 Homo sapiens 146-151 35405615-0 2022 Capsaicin ameliorates intermittent high glucose-mediated endothelial senescence via the TRPV1/SIRT1 pathway. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 35405615-13 2022 Capsaicin restored AMPK phosphorylation and IHG-inhibited TRPV1 expression. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 35405615-14 2022 Moreover, TRPV1 silencing suppressed SIRT1 expression and abolished the anti-senescence effects of capsaicin. Capsaicin 99-108 transient receptor potential cation channel subfamily V member 1 Homo sapiens 10-15 35405615-15 2022 CONCLUSION: Capsaicin elevates SIRT1 levels through TRPV1/(Ca2+)i/CaMKII/AMPK pathway and suppresses IHG-mediated endothelial cell senescence. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 35478041-6 2022 Channel-dependent evoked responses were detected using the TRPV1 agonist capsaicin, a TRPA1 agonist, allyl isothiocyanate (AITC), and TRPM8 agonist menthol. Capsaicin 73-82 transient receptor potential cation channel subfamily V member 1 Homo sapiens 59-64 35473456-4 2022 METHODS: Healthy (BEAS-2B) and cancer-derived (Calu-3) airway epithelial cell lines were assessed for changes to TRPV1 protein expression and mRNA expression following exposure to capsaicin (5-50 microM), and TRPV1 modulators including heat (43 C), and hydrochloric acid (pH 3.4 to pH 6.4). Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 113-118 35436739-0 2022 Activation of TRPV1 by capsaicin-loaded CaCO3 nanoparticle for tumor-specific therapy. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 35436739-2 2022 Here, we report an acid-responsive CaCO3 nanoparticle loaded with capsaicin that can specifically activate TRPV1 channels and trigger tumor calcium ion therapy. Capsaicin 66-75 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 35436739-4 2022 The released capsaicin can specifically activate TRPV1 channel, overloading the intracellular calcium ion concentration and causing cell apoptosis, which provides a new safer and cheaper treatment. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 35121102-5 2022 The mRNA expression of transient receptor potential vanilloid 1 (TRPV1), a cough sensor activated by capsaicin, in tracheal tissues was determined. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-63 35121102-5 2022 The mRNA expression of transient receptor potential vanilloid 1 (TRPV1), a cough sensor activated by capsaicin, in tracheal tissues was determined. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 65-70 35398988-6 2022 The released capsaicin can further activate transient receptor potential cation channel subfamily V member 1 (TRPV1) of U373 cancer cells, leading to an influx of calcium ions into cells. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 44-108 35398988-6 2022 The released capsaicin can further activate transient receptor potential cation channel subfamily V member 1 (TRPV1) of U373 cancer cells, leading to an influx of calcium ions into cells. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 35499773-6 2022 CONCLUSION: As the overall effect of topical capsaicin application was higher in HS for QST, we suggest the existence of a sensitization of TRPV1 channels in RA patients caused by long-time chronical inflammation, despite a lack of clinical signs of inflammation due to adequate treatment. Capsaicin 45-54 transient receptor potential cation channel subfamily V member 1 Homo sapiens 140-145 35499773-10 2022 Key Points The effect of topical capsaicin may represent the extent of TRPV1 sensitization in rheumatoid arthritis. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 35163843-8 2022 TRPA1 and TRPV1 activation (100 microM AITC, 100 nM capsaicin) induced 45Ca2+-influx into PE/CA-PJ41 cells. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 10-15 35458680-2 2022 The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons. Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 35458680-9 2022 These contradictory results may be caused by the fact that capsaicin influences not only TRPV1 channels but also different molecular targets such as voltage-gated sodium channels. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-94 35350319-5 2022 We demonstrate that endogenous TRPV1 is functional and causes Ca2+ influx upon activation with pharmacological activators (resiniferatoxin (RTX) and capsaicin) at nanomolar concentration, which enhances the generation of osteoclasts, whereas the TRPV1 inhibitor (5"-IRTX) reduces osteoclast differentiation. Capsaicin 149-158 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 35350319-5 2022 We demonstrate that endogenous TRPV1 is functional and causes Ca2+ influx upon activation with pharmacological activators (resiniferatoxin (RTX) and capsaicin) at nanomolar concentration, which enhances the generation of osteoclasts, whereas the TRPV1 inhibitor (5"-IRTX) reduces osteoclast differentiation. Capsaicin 149-158 transient receptor potential cation channel subfamily V member 1 Homo sapiens 246-251 35350319-7 2022 The slow release of capsaicin or RTX at a nanomolar concentration from a polysaccharide-based hydrogel enhances bone marrow macrophage (BMM) differentiation into osteoclasts whereas release of 5"-IRTX, an inhibitor of TRPV1, prevents macrophage fusion and osteoclast formation. Capsaicin 20-29 transient receptor potential cation channel subfamily V member 1 Homo sapiens 218-223 35212819-4 2022 PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS). Capsaicin 193-202 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-120 35212819-4 2022 PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS). Capsaicin 193-202 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 35212819-4 2022 PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS). Capsaicin 193-202 transient receptor potential cation channel subfamily V member 1 Homo sapiens 171-176 35212819-4 2022 PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS). Capsaicin 204-207 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-120 35212819-4 2022 PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS). Capsaicin 204-207 transient receptor potential cation channel subfamily V member 1 Homo sapiens 171-176 35163843-6 2022 Radioactive 45Ca2+ uptake and ATP-based luminescence indicating cell viability were measured in PE/CA-PJ41 cells in response to the TRPA1 agonist allyl-isothiocyanate (AITC) and TRPV1 agonist capsaicin to determine receptor function. Capsaicin 192-201 transient receptor potential cation channel subfamily V member 1 Homo sapiens 178-183 35071508-1 2022 BACKGROUND: Transient receptor potential vanilloid-1 (TRPV1), a nonselective cation channel, is activated by capsaicin, a pungent ingredient of hot pepper. Capsaicin 109-118 transient receptor potential cation channel subfamily V member 1 Homo sapiens 54-59 34751390-5 2022 In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-101 34751390-5 2022 In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 34751390-5 2022 In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO. Capsaicin 33-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-101 34751390-5 2022 In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO. Capsaicin 33-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 35057413-1 2022 Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-70 35057413-1 2022 Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 35057413-1 2022 Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-70 35057413-1 2022 Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 35214061-0 2022 The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 78-83 35214061-7 2022 Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-124 35214061-7 2022 Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 35214061-7 2022 Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 140-145 35214061-8 2022 Altogether, our results showed that capsaicin affected AMPK activity in an LKB1- and TRPV1-dependent fashion, linking TRPV1 with cell fate. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 85-90 35214061-8 2022 Altogether, our results showed that capsaicin affected AMPK activity in an LKB1- and TRPV1-dependent fashion, linking TRPV1 with cell fate. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-123 35071508-2 2022 Previous studies have suggested a link between obesity and capsaicin-associated pathways, and activation of TRPV1 may provide an alternative approach for obesity treatment. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 108-113 32781866-6 2021 TRPA1, TRPM2 and TRPV1 of the eight groups were further stimulated by cinnamaldehyde, cumene hydyroperoxide and capsaicin, respectively although they were further inhibited by AP-18, N-(p-Amylcinnamoyl) anthranilic acid (ACA) and capsazepine (CPZ). Capsaicin 112-121 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 33407019-12 2021 These results suggest that capsaicin or other therapeutic strategies to increase Ca2+ accumulation via TRPV1 might be more effective than hyperthermic therapy for Type I diabetic patients. Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 33937226-0 2021 Activation of TRPV1 by Capsaicin or Heat Drives Changes in 2-Acyl Glycerols and N-Acyl Ethanolamines in a Time, Dose, and Temperature Dependent Manner. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 33937226-2 2021 TRPV1, a calcium-permeable ion channel, is activated by capsaicin, elevated temperature, the eCB Anandamide, and over 15 additional endogenous lipids. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 33937226-4 2021 We recently found that activation of TRPV1-HEK cells by capsaicin increases the production of the eCB, 2-arachidonoyl glycerol (2-AG), suggesting a molecular link between these receptors. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 33937226-5 2021 Here, we tested the hypothesis that TRPV1 activation by capsaicin drives regulation of a wider-range of lipid signaling molecules and is time and dose-dependent. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-41 34043299-1 2021 Transient receptor potential vanilloid (TRPV) channels are part of the TRP channel superfamily and named after the first identified member TRPV1, that is sensitive to the vanillylamide capsaicin. Capsaicin 185-194 transient receptor potential cation channel subfamily V member 1 Homo sapiens 139-144 33493995-3 2021 Topical capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has been proposed in recent years as a low-cost and effective alternative to the traditional antiemetic regimen when treating CHS. Capsaicin 8-17 transient receptor potential cation channel subfamily V member 1 Homo sapiens 21-61 33493995-3 2021 Topical capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has been proposed in recent years as a low-cost and effective alternative to the traditional antiemetic regimen when treating CHS. Capsaicin 8-17 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 33837959-11 2021 LAMEA binds to the capsaicin-binding pocket of TRPV1. Capsaicin 19-28 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 33550097-2 2021 Transient receptor potential vanilloid 1 (TRPV1) is the specific receptor of capsaicin. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 33181192-2 2021 Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-76 33181192-2 2021 Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 78-83 33181192-2 2021 Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain. Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 36-76 33181192-2 2021 Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain. Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 78-83 33181192-8 2021 By contrast, high concentrations of capsaicin lead to long-term defunctionalization mediated by the ablation of TRPV1-expressing afferent terminals, resulting in long-lasting analgesia persisting for several months. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 33752082-0 2021 Gating of the capsaicin receptor TRPV1 by UVA-light and oxidants are mediated by distinct mechanisms. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 33-38 33752082-2 2021 Oxidants and UVA-light activate TRPV2 by oxidizing methionine pore residues which are conserved in the capsaicin-receptor TRPV1. Capsaicin 103-112 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-127 33550097-2 2021 Transient receptor potential vanilloid 1 (TRPV1) is the specific receptor of capsaicin. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 33550097-4 2021 The aim of this study was to investigate the effects of capsaicin-activated TRPV1 on VSMC phenotypic switching. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 33550097-7 2021 Nevertheless, the data showed that capsaicin activated TRPV1 significantly decreased ox-LDL-induced superoxide anion generation. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 55-60 32959171-5 2021 Furthermore, adult sensory neurons with DUSP knockdown were rendered sensitive to axonopathy in vitro following exposure to low, subtoxic TrpV1 (transient receptor potential cation channel subfamily V member 1) activation by capsaicin, an intervention normally supportive of growth. Capsaicin 225-234 transient receptor potential cation channel subfamily V member 1 Homo sapiens 138-143 32827294-1 2021 Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation of migraine pain. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-45 32827294-1 2021 Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation of migraine pain. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 33546181-1 2021 Capsaicin is a potent agonist of the TRPV1 channel, a transduction channel that is highly expressed in nociceptive fibers (pain fibers) throughout the peripheral nervous system. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 33546181-6 2021 Capsaicin overcomes both liabilities by disrupting peripheral terminals of nociceptive fibers that express TRPV1, and thereby affects all of the potential means of activating that pain fiber (not just TRPV1 function). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 33546181-6 2021 Capsaicin overcomes both liabilities by disrupting peripheral terminals of nociceptive fibers that express TRPV1, and thereby affects all of the potential means of activating that pain fiber (not just TRPV1 function). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 201-206 33546181-9 2021 By disrupting the entire terminal of the TRPV1-expressing nociceptive fiber, capsaicin blocks all the activation mechanisms within that fiber, and not just TRPV1 function. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 33160235-6 2021 Obviously, the order of the sensitivity mediated by hTRPV1 was capsaicin > sanshool > allicin. Capsaicin 63-72 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-58 33420359-6 2021 We report that AG1529 competitively blocked capsaicin-evoked activation of hTRPV1 with micromolar potency, moderately affected pH-induced gating, and did not alter voltage- and heat-mediated responses. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 75-81 33165872-1 2021 The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators. Capsaicin 33-42 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 33165872-1 2021 The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators. Capsaicin 148-157 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-44 33165872-1 2021 The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators. Capsaicin 148-157 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 32701656-8 2021 Thus, capsaicin morphed the descriptor pattern of the blade to become more capsaicin-like, which is probably explained best by peripheral sensitization of the TRPV1 receptor. Capsaicin 6-15 transient receptor potential cation channel subfamily V member 1 Homo sapiens 159-164 32701656-8 2021 Thus, capsaicin morphed the descriptor pattern of the blade to become more capsaicin-like, which is probably explained best by peripheral sensitization of the TRPV1 receptor. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 159-164 33424555-6 2020 Perfusion of the TRPV1 agonist, capsaicin (1 muM), transiently increased the firing frequency in approximately 46-48% of the cold-sensitive nerves characterized by low-background activity and high threshold (LB-HT) cold thermoreceptors in both groups. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 33376801-10 2020 Capsaicin and anandamide (AEA) activated TRPV1 receptors with an EC50 of 61 nM and 4.3 muM, respectively, but TRPV1 showed no response to Delta9-THC, cannabidiol, and other minor cannabinoids. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 33508148-7 2021 Initial mechanistic studies indicated that membrane receptors, such as capsaicin receptor VR1/TRPV1, opioid receptors, and P2X3 receptors, might be involved. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 90-93 33508148-7 2021 Initial mechanistic studies indicated that membrane receptors, such as capsaicin receptor VR1/TRPV1, opioid receptors, and P2X3 receptors, might be involved. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 94-99 33420359-0 2021 A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability. Capsaicin 2-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 32959171-5 2021 Furthermore, adult sensory neurons with DUSP knockdown were rendered sensitive to axonopathy in vitro following exposure to low, subtoxic TrpV1 (transient receptor potential cation channel subfamily V member 1) activation by capsaicin, an intervention normally supportive of growth. Capsaicin 225-234 transient receptor potential cation channel subfamily V member 1 Homo sapiens 145-209 32763303-0 2020 Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 11-16 33038582-1 2020 Capsaicin (N-vanillyl-8-methyl-alpha-nonenamide), a spicy, neurotoxic component of hot pepper is a ligand of vanilloid type-I (TRPV1) receptor of anti-cancer potential. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 127-132 33187307-6 2020 In agreement with these observations, TRPV1 protein was expressed and capsaicin, a selective TRPV1 agonist, induced Ca2+ influx by engaging both TRPV1 and NCX in mCRC cells. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 93-98 33187307-6 2020 In agreement with these observations, TRPV1 protein was expressed and capsaicin, a selective TRPV1 agonist, induced Ca2+ influx by engaging both TRPV1 and NCX in mCRC cells. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 93-98 33262985-8 2020 In contrast, TRPV1 was slightly activated in hCMEC/D3 cells as shown by the weak Ca2+ influx induced by capsaicin at a high concentration (3 muM), a highly potent and specific TRPV1 agonist. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 33262985-8 2020 In contrast, TRPV1 was slightly activated in hCMEC/D3 cells as shown by the weak Ca2+ influx induced by capsaicin at a high concentration (3 muM), a highly potent and specific TRPV1 agonist. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 176-181 32882205-9 2020 Ketamine also prevented TRPV1 receptor desensitization induced by successive applications of capsaicin. Capsaicin 93-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 32882205-11 2020 Taken together, our data indicate that ketamine potentiates TRPV1 receptor sensitivity to capsaicin through a mechanism dependent on PKCie activity. Capsaicin 90-99 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-65 32040846-2 2020 Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se). Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 32040846-2 2020 Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se). Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 32771398-0 2020 Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 100-105 32771398-5 2020 In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-95 32771398-5 2020 In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells. Capsaicin 32-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-102 32771398-5 2020 In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells. Capsaicin 43-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-95 32771398-5 2020 In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells. Capsaicin 43-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-102 32771398-6 2020 Capsaicin treatment triggered Ca2+ influx by TRPV1 activation, resulting in disequilibrium of intracellular calcium homeostasis. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-50 32771398-10 2020 It was worth noting that both TRPV1 antagonist (capsazepine) and calcium chelator (BAPTA) could attenuate aberrant Ca2+ homeostasis, mitochondrial dysfunction and apoptosis induced by capsaicin treatment. Capsaicin 184-193 transient receptor potential cation channel subfamily V member 1 Homo sapiens 30-35 32771398-11 2020 Thus, our study demonstrated that capsaicin induced mitochondrial calcium overload and apoptosis in ATC cells through a TRPV1-mediated pathway. Capsaicin 34-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 120-125 32820172-2 2020 The TRPV1 ion channel is a well-studied heat-sensing receptor that is also activated by vanilloid compounds, including capsaicin. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 32712260-1 2020 PURPOSE: To evaluate transient receptor potential vanilloid 1 (TRPV1)-mediated pain sensitivity in patients with short tear break-up time (TBUT) dry eye (DE) by using the capsaicin stimulus test. Capsaicin 171-180 transient receptor potential cation channel subfamily V member 1 Homo sapiens 21-61 32712260-1 2020 PURPOSE: To evaluate transient receptor potential vanilloid 1 (TRPV1)-mediated pain sensitivity in patients with short tear break-up time (TBUT) dry eye (DE) by using the capsaicin stimulus test. Capsaicin 171-180 transient receptor potential cation channel subfamily V member 1 Homo sapiens 63-68 33204332-10 2020 Finally, we elevated the translational potential of this study by showing that RvD3 significantly inhibited capsaicin-induced TRPV1 activity and CGRP release in human DRG neurons. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 32833423-10 2020 Molecular modeling data revealed that KA binds to TRPV1 and prebinding with capsaicin prevents the binding of KA to TRPV1. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-121 32651226-3 2020 The TRPV1 agonists capsaicin and piperine have been shown to increase salivary flow when introduced into the oral cavity but the sialogogic properties of other TRP channel agonists have not been investigated. Capsaicin 19-28 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 33101845-1 2020 While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel"s responses to each of these stimuli are profoundly regulated by membrane potential, damping or even prohibiting its response at negative voltages and amplifying its response at positive voltages. Capsaicin 10-19 transient receptor potential cation channel subfamily V member 1 Homo sapiens 71-76 33101845-1 2020 While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel"s responses to each of these stimuli are profoundly regulated by membrane potential, damping or even prohibiting its response at negative voltages and amplifying its response at positive voltages. Capsaicin 122-131 transient receptor potential cation channel subfamily V member 1 Homo sapiens 71-76 32634675-8 2020 Our recordings also revealed that DPH partially blocked capsaicin evoked TRPV1 currents. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 32532587-2 2020 Recent cryoelectron microscopy (cryo-EM) studies of TRPM8 have shown distinct structural features in its architecture and domain assembly compared with the capsaicin receptor TRP vanilloid member 1 (TRPV1). Capsaicin 156-165 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 32511032-7 2020 It is important to note that, as the mechanism of action of capsaicin 8% is the "defunctionalization" of small afferent fibers through interaction with TRPV1 receptors, the peripheral expression of this receptor on nociceptor fibers, is crucial to predict patient"s response to treatment. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 152-157 32753716-4 2020 Between 30-32 C, SEAP production was strongly potentiated 3.3-fold by the addition of the TRPV1 agonist capsaicin. Capsaicin 105-114 transient receptor potential cation channel subfamily V member 1 Homo sapiens 91-96 31482758-2 2020 Standard antiemetic therapy is often ineffective; however, capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1), has shown promise in treating CHS. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 84-124 32586044-2 2020 Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-96 32586044-2 2020 Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 98-103 32586044-2 2020 Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 105-123 32514053-1 2020 The vanilloid capsaicin is a widely consumed spice, known for its burning and "hot" sensation through activation of TRPV1 ion-channels, but also known to decrease oxidative stress, inflammation and influence tau-pathology. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-121 32760273-0 2020 Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin. Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 6-11 32760273-2 2020 Activated by capsaicin, heat, voltage and protons, it is also well known for its desensitization, which led to the medical use of topically applied TRPV1 agonist capsaicin for its long-lasting analgesic effects. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 148-153 32760273-2 2020 Activated by capsaicin, heat, voltage and protons, it is also well known for its desensitization, which led to the medical use of topically applied TRPV1 agonist capsaicin for its long-lasting analgesic effects. Capsaicin 162-171 transient receptor potential cation channel subfamily V member 1 Homo sapiens 148-153 32345612-1 2020 The transient receptor potential vanilloid 1 (TRPV1) channel is activated by heat and by capsaicin, the pungent compound in chili peppers. Capsaicin 89-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-51 31482758-2 2020 Standard antiemetic therapy is often ineffective; however, capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1), has shown promise in treating CHS. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 32371130-0 2020 Probing temperature and capsaicin-induced activation of TRPV1 channel via computationally guided point mutations in its pore and TRP domains. Capsaicin 24-33 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 32377171-8 2020 Furthermore, we found that administration of the TRPV1 agonist capsaicin (Cap) reversed the effects of Dex on proinflammatory cytokines; however, the expression and activation of PKA-STAT3 and PKC-NF-kappaB signals were not altered owing to Cap administration. Capsaicin 63-72 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 31926897-2 2020 TRPV1 can be activated by capsaicin (CAP), protons (low pH), and heat. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 32316463-8 2020 Using calcium imaging, we observed that a proportion of cells responded to histamine, SLIGKV (a specific agonist of PAR2), polygodial (a specific agonist of TRPA1), and capsaicin (a specific agonist of TRPV1). Capsaicin 169-178 transient receptor potential cation channel subfamily V member 1 Homo sapiens 202-207 31935455-0 2020 Multiple single nucleotide polymorphisms of the transient receptor potential vanilloid 1 (TRPV1) genes associate with cough sensitivity to capsaicin in healthy subjects. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 90-95 31935455-3 2020 Capsaicin (CPS) activates TRPV1 and is regularly used as a tool to study cough response. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-31 31935455-3 2020 Capsaicin (CPS) activates TRPV1 and is regularly used as a tool to study cough response. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-31 31935455-4 2020 Although single nucleotide polymorphisms (SNPs) of TRPV1 are implicated in CPS binding, their role in cough response is not fully elucidated. Capsaicin 75-78 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 31935455-5 2020 AIMS: In this study we investigated the relationship between capsaicin cough challenge sensitivity and multiple TRPV1 polymorphisms. Capsaicin 61-70 transient receptor potential cation channel subfamily V member 1 Homo sapiens 112-117 31935455-8 2020 The association between combinations of TRPV1 SNPs and CPS sensitivity of each subject was assessed by linear regression. Capsaicin 55-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 31935455-12 2020 CONCLUSION: Capsaicin cough challenge sensitivity in healthy subjects is dependent on multiple TRPV1 polymorphisms. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 95-100 31926897-2 2020 TRPV1 can be activated by capsaicin (CAP), protons (low pH), and heat. Capsaicin 37-40 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 31926897-4 2020 Second-generation (mode-selective) TRPV1 antagonists potently block channel activation by CAP, but exert different effects (e.g., potentiation, no effect, or low-potency inhibition) in the proton mode, heat mode, or both. Capsaicin 90-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 35-40 31757360-2 2020 TRPV1 can be activated by low extracellular pH, high temperature, or naturally occurring pungent molecules such as allicin, capsaicin, or resiniferatoxin. Capsaicin 124-133 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 31712319-3 2020 Capsaicin, a dietary factor activating TRPV1, can inhibit obesity induced by high-fat diet (HFD), but whether capsaicin inhibits BAT loss and the underlying mechanism remain unclear. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 39-44 31661581-6 2020 Phenylephrine at 30 mM caused calcium transients in cultured trigeminal ganglion neurons responding to the TRPV1 agonist capsaicin and in HEK293T cells expressing human TRPV1. Capsaicin 121-130 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 32149229-3 2020 The addition of a nonlethal dose of ionomycin to HeLa and capsaicin to TRPV1-expressing HEK293 cells resulted in a sudden change in the magnetic field signal consistent with Ca2+ influx, which was also observed by confocal fluorescence microscopy under the same conditions. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 71-76 32149229-4 2020 In contrast, addition of capsaicin to TRPV1-expressing HEK293 cells containing an optimum amount of a TRPV1 antagonist (ruthenium red), resulted in no detectable magnetic or fluorescent signals. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 38-43 32149229-4 2020 In contrast, addition of capsaicin to TRPV1-expressing HEK293 cells containing an optimum amount of a TRPV1 antagonist (ruthenium red), resulted in no detectable magnetic or fluorescent signals. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-107 31864799-3 2020 Among them, antagonist 36 exhibited potent and selective antagonism toward capsaicin for hTRPV1 and mTRPV1. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 89-95 31998070-1 2019 The tetrameric capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) in mammals has evolved the capability to integrate pain signal arising from harmful temperature and chemical irritants. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 76-81 31952468-7 2020 In DRG neurons and TRPV1-expressing HEK cells, heat sensitivity was restricted to capsaicin sensitive cells. Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 19-24 31998070-4 2019 By introducing capsaicin-insensitive S512F mutant subunits into the TRPV1 channel, we found that binding of the first ligand results in low but clear channel activation. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-73 31998070-6 2019 The non-vanilloid agonist 2-aminoethoxydiphenyl borate (2-APB) differs from that of capsaicin in the TRPV1 channel opening mechanism activating all S512F-mutated TRPV1 channels. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 101-106 31998070-6 2019 The non-vanilloid agonist 2-aminoethoxydiphenyl borate (2-APB) differs from that of capsaicin in the TRPV1 channel opening mechanism activating all S512F-mutated TRPV1 channels. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 162-167 31998070-7 2019 Two or more wild-type TRPV1 subunits are also required for full anandamide-induced channel activation, a cannabinoid that shares overlapping binding-pocket to capsaicin. Capsaicin 159-168 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 31241438-3 2020 Another heteroaryl urea derivative, A-425619 1, has been reported to be a potent and selective TRPV1 antagonist of capsaicin-evoked receptor activation with an IC50 value of 4 nM in hTRPV1. Capsaicin 115-124 transient receptor potential cation channel subfamily V member 1 Homo sapiens 182-188 32378567-3 2020 Here we investigated the effect of the prototypical TRPV1 agonist capsaicin and selected opioid ligands on TRPV1 movement in the plasma membrane and intracellular calcium levels in HEK293 cells expressing TRPV1 tagged with cyan fluorescent protein (CFP). Capsaicin 66-75 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 32378567-3 2020 Here we investigated the effect of the prototypical TRPV1 agonist capsaicin and selected opioid ligands on TRPV1 movement in the plasma membrane and intracellular calcium levels in HEK293 cells expressing TRPV1 tagged with cyan fluorescent protein (CFP). Capsaicin 66-75 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 31647972-1 2020 Capsaicin, an agonist of TRPV1, evokes intracellular [Ca2+] transients and glutamate release from perfused trigeminal ganglion. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-30 31647972-4 2020 PnTx3-5 (40 nM) and SB-366791 (3 muM) also inhibited the capsaicin-induced increase in intracellular Ca2+ in HEK293 cells transfected with TRPV1 by 75 +- 16 % and 84 +- 3.2 %, respectively. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 139-144 32378567-4 2020 We observed that lateral mobility of TRPV1 increased after treatment of cells with capsaicin or naloxone (a nonselective opioid receptor antagonist) but not with DAMGO (a mu-opioid receptor agonist). Capsaicin 83-92 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 32378567-6 2020 The increased TRPV1 movement and calcium influx induced by capsaicin and naloxone were blocked by the TRPV1 antagonist capsazepine. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 32378567-6 2020 The increased TRPV1 movement and calcium influx induced by capsaicin and naloxone were blocked by the TRPV1 antagonist capsazepine. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-107 32581185-4 2020 Further, there are several reports showing that capsaicin, a specific agonist of TRPV1, can improve OD. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 81-86 31647972-6 2020 In whole-cell patch-clamp experiments on HEK293 cells transfected with TRPV1, capsaicin (10 muM) generated inward currents that were blocked by SB-366791 and by both native and recombinant PnTx3-5 by 47 +- 1.4 %; 54 +- 7.8 % and 56 +- 9.0 %, respectively. Capsaicin 78-87 transient receptor potential cation channel subfamily V member 1 Homo sapiens 71-76 31262222-0 2019 pHluorin-tagged TRPV1 shines light on capsaicin tachyphylaxis. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-21 31401394-6 2019 Treatment with TRPV1 agonist Capsaicin inhibits the growth of HCC cells in xenograft models. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 31681615-4 2019 TRPV1 channel, known as a capsaicin receptor, was recently documented to be expressed on the cells of the immune system but also aberrantly expressed in the several tumor types. Capsaicin 26-35 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 31681615-7 2019 Furthermore, in several studies, activation of TRPV1 by capsaicin was associated with anti-cancer effects. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 31325598-1 2019 BACKGROUND: The transient receptor potential vanilloid subtype-1 (TRPV1) channel is a calcium selective ion channel that responds to various stimuli such as heat, low pH, and capsaicin. Capsaicin 175-184 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-64 31325598-1 2019 BACKGROUND: The transient receptor potential vanilloid subtype-1 (TRPV1) channel is a calcium selective ion channel that responds to various stimuli such as heat, low pH, and capsaicin. Capsaicin 175-184 transient receptor potential cation channel subfamily V member 1 Homo sapiens 66-71 31314954-10 2019 This study also proved that TRPV1 antagonists can inhibit a more complex, non-capsaicin dependent thermally induced pain signal. Capsaicin 78-87 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-33 31026506-4 2019 When expressed by sensory neurons, activation of TRPV1 channels by heat (>40 C), capsaicin (sub-micromolar), or acid environment (pH < 6), causes depolarization leading to burning pain sensation in mammals. Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 31566018-3 2022 The effect of capsaicin through sensory neurons via TRPV1 activation has been well studied, but its non-neuronal effects are still not extensively explored. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-57 30989631-4 2019 We identify a bidirectional, dose-related impact of capsaicin, a TRPV1 agonist, on sensory neurons and their axons with rises in their outgrowth plasticity at low doses and toxic neurodegeneration at high doses. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 65-70 31202991-2 2019 The SAR analysis indicated that 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole analogues displayed excellent antagonism of hTRPV1 activation by capsaicin and showed better potency compared to the corresponding dihydroindole analogues. Capsaicin 139-148 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-124 31202991-4 2019 In vitro, using cells expressing recombinant human TRPV1 channels, 6g displayed potent antagonism activated by capsaicin (IC50 = 0.075 muM) and only partially blocked acid activation of TRPV1. Capsaicin 111-120 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 31487785-2 2019 Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown. Capsaicin 192-201 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-80 31487785-2 2019 Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown. Capsaicin 192-201 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 31487785-2 2019 Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown. Capsaicin 203-206 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-80 31487785-2 2019 Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown. Capsaicin 203-206 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 31399015-5 2019 Expert opinion: The therapeutic effect of TRPV1 channel desensitizing agonists (capsaicin, resiniferatoxin, given intravesically) has been convincingly demonstrated in some forms of bladder overactivity. Capsaicin 80-89 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 30938826-5 2019 In CP-W, pinprick hyperalgesia and increased sensitivity to capsaicin were aligned with increased epidermal TRPV1 expression, while smaller histamine axon reflex erythema matched with significantly reduced intraepidermal nerve fiber density. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 108-113 30672650-8 2019 Heat acclimation may induce capsaicin tolerance via the downregulation of TRPV1. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 31263706-6 2019 TRPV1 can be activated by a large array of physical (heat, mechanical stimuli) and chemical factors (e.g., protons, capsaicin, resiniferatoxin, and endogenous ligands, such as endovanilloids). Capsaicin 116-125 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 31095448-0 2019 Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 31095448-4 2019 We found that capsaicin-induced apoptosis and the activation of transient receptor potential receptor vanilloid 1 (TRPV1) in a dose- and time-dependent manner in human osteosarcoma MG63 cells in vitro. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 64-113 31095448-4 2019 We found that capsaicin-induced apoptosis and the activation of transient receptor potential receptor vanilloid 1 (TRPV1) in a dose- and time-dependent manner in human osteosarcoma MG63 cells in vitro. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-120 31095448-5 2019 Blocking TRPV1 using capsazepine attenuated the capsaicin-induced cytotoxicity, mitochondrial dysfunction, overproduction of reactive oxygen species (ROS) and decrease in superoxide dismutase (SOD) activity. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 9-14 31095448-8 2019 Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 143-148 31095448-8 2019 Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 226-231 30935063-2 2019 Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. Capsaicin 113-122 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 31068978-2 2019 The aim of this proof-of-concept study was to assess the biomechanical and neurophysiological effects of acute and subacute oropharyngeal sensory stimulation with transient receptor potential vanilloid 1 (TRPV1) agonists (capsaicinoids) in older patients with OD. Capsaicin 222-235 transient receptor potential cation channel subfamily V member 1 Homo sapiens 163-203 30935063-2 2019 Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation. Capsaicin 113-122 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 30159798-2 2019 In addition to the actions of capsaicin (CAP) and reactive oxygen species (ROS), the TRPV1 channel is activated in neurons by endogenous cannabinoid, anandamide (AEA). Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 85-90 30871017-1 2019 Capsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1. Capsaicin 39-48 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 30159798-2 2019 In addition to the actions of capsaicin (CAP) and reactive oxygen species (ROS), the TRPV1 channel is activated in neurons by endogenous cannabinoid, anandamide (AEA). Capsaicin 41-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 85-90 30159798-11 2019 The TRPV1 channel is activated by different stimuli including reactive oxygen species (ROS), anandamide (AEA), and CAP and it is blocked by capsazepine (CPZ). Capsaicin 115-118 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 30278281-3 2019 In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 3b displayed potent antagonism activated by capsaicin (IC50 = 0.084 muM) and protons (IC50 = 0.313 muM). Capsaicin 130-139 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 30761248-7 2019 Furthermore, TRPV1 was activated by capsaicin (EC 50 = 20.32 mum), and this effect was antagonized by AMG9810; TRPV2 was activated by a newly developed cannabinoid compound, O1821, and inhibited by tranilast. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 30294815-2 2019 We hypothesized that regardless of environmental temperature, capsaicin application would stimulate heat loss and concomitantly deactivate heat conservation mechanisms, thus resulting in rectal temperature (Tre) and mean blood pressure decline due to excitation of heat-sensitive TRPV1. Capsaicin 62-71 transient receptor potential cation channel subfamily V member 1 Homo sapiens 280-285 30761069-5 2019 Results: In in vitro experiments, TRPV1 stimulation by capsaicin significantly reduced TNF and IL-6 release by activated microglial cells. Capsaicin 55-64 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 30644819-3 2019 It was recently discovered that four mutations in TRPV2 are sufficient to render the channel sensitive to the TRPV1-specific vanilloid agonist resiniferatoxin (RTx). Capsaicin 125-134 transient receptor potential cation channel subfamily V member 1 Homo sapiens 110-115 30644819-4 2019 Here, we show that mutation of six residues in TRPV3 corresponding to the vanilloid site in TRPV1 is sufficient to engineer RTx binding. Capsaicin 74-83 transient receptor potential cation channel subfamily V member 1 Homo sapiens 92-97 30518154-8 2018 (4) Conclusions: Long-term activation of TRPV1 is imminent for the anti-obesity effect of capsaicin. Capsaicin 90-99 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 30518154-2 2018 Although capsaicin and its nonpungent analogs are shown to enhance energy expenditure, their efficiency to bind to and activate their receptor-transient receptor potential vanilloid subfamily 1 (TRPV1)-to mediate thermogenic effects remains unclear. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-193 30518154-2 2018 Although capsaicin and its nonpungent analogs are shown to enhance energy expenditure, their efficiency to bind to and activate their receptor-transient receptor potential vanilloid subfamily 1 (TRPV1)-to mediate thermogenic effects remains unclear. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 195-200 30518154-6 2018 Molecular docking studies indicate that capsaicin exhibits the highest binding efficacy to TRPV1 because it has a hydrogen bond that anchors it to TRPV1. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 91-96 30518154-6 2018 Molecular docking studies indicate that capsaicin exhibits the highest binding efficacy to TRPV1 because it has a hydrogen bond that anchors it to TRPV1. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 147-152 32186131-9 2018 CONCLUSION: Loureirin B plus capsaicin could produce double blockage on TRPV1 and modulation on TTX-R sodium channel. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 72-77 30409787-3 2018 Macroscopic currents activated by saturating concentrations of LPA applied to excised membrane patches are larger in magnitude than those activated by saturating concentrations of capsaicin, which causes near-maximal TRPV1 open probability. Capsaicin 180-189 transient receptor potential cation channel subfamily V member 1 Homo sapiens 217-222 30409787-4 2018 Here we show that activation of TRPV1 by LPA is associated with a higher single-channel conductance than activation by capsaicin. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 30207782-4 2018 Here, we show that the TRPV1 agonist capsaicin (100 nM) and hyperosmotic solution (350 vs. 300 mosM) each caused an increase of bumetanide-inhibitable Rb uptake by intact porcine lenses and Na-K-2Cl cotransporter 1 (NKCC1) phosphorylation in the lens epithelium. Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-28 29847470-4 2018 This human experimental study investigated whether functional responses from the subpopulation of TRPA1 nociceptors could be evoked after defunctionalization of TRPV1 nociceptors by cutaneous application of high-concentration capsaicin. Capsaicin 226-235 transient receptor potential cation channel subfamily V member 1 Homo sapiens 161-166 30483120-2 2018 3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells. Capsaicin 157-166 transient receptor potential cation channel subfamily V member 1 Homo sapiens 119-134 30483120-2 2018 3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells. Capsaicin 157-166 transient receptor potential cation channel subfamily V member 1 Homo sapiens 136-141 30706039-1 2018 Introduction: NEO6860 is a TRPV1 antagonist when activated by capsaicin but not by heat or pH, developed to relieve pain without the adverse events reported with non-modality-selective TRPV1 antagonists. Capsaicin 62-71 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 30274279-6 2018 The capacity of DPV576 to modulate the activity of TRPV1 agonist capsaicin in CD4+ T cells was also determined. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 30274279-9 2018 This was accompanied by decreased secretion of IFN-gamma and reduced expression of TRPV1 in capsaicin activated CD4+ T cells. Capsaicin 92-101 transient receptor potential cation channel subfamily V member 1 Homo sapiens 83-88 30244119-0 2018 TRPV1 mediates capsaicin-stimulated metabolic activity but not cell death or inhibition of interleukin-1beta release in human THP-1 monocytes. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 30244119-8 2018 Capsaicin-stimulated THP-1 metabolic activity was blocked by the TRPV1 antagonist, 5-iodo-resiniferatoxin (5"-IRTX), whereas the decline in resorufin production by THP-1 cells at higher capsaicin concentrations (due to cell death), was not affected by 5"-IRTX. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 65-70 30524369-4 2018 The TRPV1 agonist capsaicin increased both intracellular Ca2+ levels and whole-cell currents, while the antagonist capsazepine (CPZ) inhibited them. Capsaicin 18-27 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 30226565-5 2018 Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression. Capsaicin 189-198 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 29847470-12 2018 Ablation of cutaneous capsaicin-sensitive afferents caused consistent and equal inhibition of both TRPV1- and TRPA1-provoked responses assessed psychophysically and by imaging of vasomotor responses. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 99-104 29847470-13 2018 This study suggests that TRPA1 nociceptive responses in human skin strongly depend on intact capsaicin-sensitive, TRPV1 fibers. Capsaicin 93-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 114-119 30251173-1 2018 The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 140-180 30067911-8 2018 One of the five anesthetic binding sites reported was previously identified experimentally, and another one, importantly, is identical to that of capsaicin, one of the chemical stimuli that activate TRPV1. Capsaicin 146-155 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 30251173-1 2018 The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain. Capsaicin 13-22 transient receptor potential cation channel subfamily V member 1 Homo sapiens 182-188 30251173-1 2018 The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain. Capsaicin 99-108 transient receptor potential cation channel subfamily V member 1 Homo sapiens 140-180 30251173-1 2018 The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain. Capsaicin 99-108 transient receptor potential cation channel subfamily V member 1 Homo sapiens 182-188 30078610-2 2018 The analysis of the structure-activity relationship indicated that 2-(3,5-dihalo 4-aminophenyl)acetamide analogues displayed excellent antagonism of hTRPV1 activation by capsaicin and showed improved potency compared to the corresponding propanamides. Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 149-155 29427475-0 2018 Application of an 8% capsaicin patch normalizes epidermal TRPV1 expression but not the decreased intraepidermal nerve fibre density in patients with brachioradial pruritus. Capsaicin 21-30 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 29427475-9 2018 CONCLUSION: The normalization of the decreased TRPV1 expression may account for the effectiveness of topical capsaicin, which does not reconstitute the reduced IENFD, arguing for a role of epidermal TRPV1 in the maintenance of BRP. Capsaicin 109-118 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 30078610-3 2018 The most potent antagonist (36) exhibited potent and selective antagonism for hTRPV1 not only to capsaicin but also to NADA and elevated temperature; however, it only displayed weak antagonism to low pH. Capsaicin 97-106 transient receptor potential cation channel subfamily V member 1 Homo sapiens 78-84 29884534-2 2018 The analysis of structure-activity relationship indicated that a fluoro group at the 3- (or/and) 5-position and a methylsulfonamido group at the 4-position were optimal for antagonism of TRPV1 activation by capsaicin. Capsaicin 207-216 transient receptor potential cation channel subfamily V member 1 Homo sapiens 187-192 29884534-3 2018 The most potent antagonist 6 not only exhibited potent antagonism of activation of hTRPV1 by capsaicin, low pH and elevated temperature but also displayed highly potent antagonism of activation of rTRPV1 by capsaicin. Capsaicin 93-102 transient receptor potential cation channel subfamily V member 1 Homo sapiens 83-89 29915934-2 2018 In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated with the release of the migraine mediator CGRP has already been widely used. Capsaicin 41-50 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 29504187-0 2018 Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model. Capsaicin 142-151 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-96 29698108-2 2018 In animals, capsaicin-based analgesic balm (CAP) attenuates the pressor response to muscle contraction, indicating the transient receptor potential vanilloid 1 (TRPv1) receptor (localized on the group IV afferent neuron) as an important mediator of the EPR. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 119-159 29698108-2 2018 In animals, capsaicin-based analgesic balm (CAP) attenuates the pressor response to muscle contraction, indicating the transient receptor potential vanilloid 1 (TRPv1) receptor (localized on the group IV afferent neuron) as an important mediator of the EPR. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 161-166 30108548-6 2018 Dietary supplementation with TRPV1 agonists, such as capsaicin, has yielded conflicting results with some studies indicating a reduction in food intake and increase in energy expenditure, and other studies indicating the converse. Capsaicin 53-62 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 30038260-6 2018 Our study provides a temporal mechanism for capsaicin activation of TRPV1. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-73 29654770-3 2018 The presence of TRPV1 in the lens was evident from RT-PCR studies and Western blot analysis of MAPK signaling pathway activation caused by the TRPV1 agonist capsaicin. Capsaicin 157-166 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-21 29654770-3 2018 The presence of TRPV1 in the lens was evident from RT-PCR studies and Western blot analysis of MAPK signaling pathway activation caused by the TRPV1 agonist capsaicin. Capsaicin 157-166 transient receptor potential cation channel subfamily V member 1 Homo sapiens 143-148 29596157-0 2018 Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin. Capsaicin 171-180 transient receptor potential cation channel subfamily V member 1 Homo sapiens 86-91 29922176-4 2018 TRPV1 is activated by pain-inducing stimuli, including inflammatory endovanilloids and pungent exovanilloids, such as capsaicin (CAP). Capsaicin 118-127 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 29922176-4 2018 TRPV1 is activated by pain-inducing stimuli, including inflammatory endovanilloids and pungent exovanilloids, such as capsaicin (CAP). Capsaicin 129-132 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 29922176-5 2018 TRPV1 activation by high doses of CAP (>10 muM) leads to necrosis, but also exhibits apoptotic characteristics. Capsaicin 34-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 29922176-10 2018 Low concentrations of CAP (1 muM) induce cell death by a mechanism involving a TRPV1-mediated rapid and transient intracellular Ca2+ increase that stimulates plasma membrane depolarization, thereby compromising plasma membrane integrity and ultimately leading to cell death. Capsaicin 22-25 transient receptor potential cation channel subfamily V member 1 Homo sapiens 79-84 29922176-11 2018 Meanwhile, higher doses of CAP induce cell death via a TRPV1-independent mechanism, involving a slow and persistent intracellular Ca2+ increase that induces mitochondrial dysfunction, plasma membrane depolarization, plasma membrane loss of integrity, and ultimately, cell death. Capsaicin 27-30 transient receptor potential cation channel subfamily V member 1 Homo sapiens 55-60 29654770-5 2018 Transient ERK1/2 and p38 MAPK phosphorylation was detected within 1 min in the epithelium isolated from intact porcine lenses exposed to capsaicin (100 nM), a selective TRPV1 agonist, and the response was significantly inhibited by A889245 (1.0 muM), a TRPV1 antagonist. Capsaicin 137-146 transient receptor potential cation channel subfamily V member 1 Homo sapiens 169-174 29654770-5 2018 Transient ERK1/2 and p38 MAPK phosphorylation was detected within 1 min in the epithelium isolated from intact porcine lenses exposed to capsaicin (100 nM), a selective TRPV1 agonist, and the response was significantly inhibited by A889245 (1.0 muM), a TRPV1 antagonist. Capsaicin 137-146 transient receptor potential cation channel subfamily V member 1 Homo sapiens 253-258 29735636-12 2018 Long-term capsaicin can protect cardiac microvessels against T2DM via suppressing oxidative/nitrative stress mediated by TRPV1/Ca2+/PGC-1alpha/OPA1 pathway in CMECs. Capsaicin 10-19 transient receptor potential cation channel subfamily V member 1 Homo sapiens 121-126 29596157-2 2018 A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates. Capsaicin 106-115 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 29953534-7 2018 Approximately 30% of total cells responded to capsaicin, indicating that they expressed an active TRPV1 channel. Capsaicin 46-55 transient receptor potential cation channel subfamily V member 1 Homo sapiens 98-103 28924972-4 2018 TRPV1 channel antagonists have suffered from side effects related to the channel"s role in temperature sensation; however, high dose formulations of capsaicin have reached the market and shown therapeutic utility. Capsaicin 149-158 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 29746471-7 2018 We previously showed that although schistosomes contain no genes predicted to encode TRPV channels, TRPV1-selective activators such as capsaicin and resiniferatoxin elicit dramatic hyperactivity in adult worms and schistosomula. Capsaicin 135-144 transient receptor potential cation channel subfamily V member 1 Homo sapiens 100-105 29772784-1 2018 Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-116 29772784-1 2018 Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-123 29772784-5 2018 These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1). Capsaicin 19-28 transient receptor potential cation channel subfamily V member 1 Homo sapiens 64-69 29772784-7 2018 Identifying suitable ways of administering capsaicin at an effective dose would warrant its clinical use through the activation of TRPV1. Capsaicin 43-52 transient receptor potential cation channel subfamily V member 1 Homo sapiens 131-136 29685681-1 2018 Capsaicin (CAP), the prototypical TRPV1 agonist, is the major active component in chili peppers with health-promoting benefits. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 29685681-1 2018 Capsaicin (CAP), the prototypical TRPV1 agonist, is the major active component in chili peppers with health-promoting benefits. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 29722529-3 2018 The implanting of an ester group in the lipophilic moiety of capsaicinoids by the Passerini multicomponent reaction affords both agonists and antagonists that retain transient receptor potential vanilloid 1 channel (TRPV1) modulating activity and, at the same time, are susceptible to hydrolysis. Capsaicin 61-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 216-221 29425725-5 2018 In particular, we (i) support the previously proposed mechanism driving thermal actuation in the extracellular pore of TRPV1, (ii) present new hypotheses regarding the thermal actuation in the C-terminal and adjacent linker domains, and (iii) support and build upon the existing hypothesis regarding the role of the vanilloid binding pocket and lipids embedded therein. Capsaicin 316-325 transient receptor potential cation channel subfamily V member 1 Homo sapiens 119-124 29377430-6 2018 RESULTS: In vitro, all three compounds were effective at inhibiting capsaicin-activated TRPV1. Capsaicin 68-77 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 29452097-1 2018 Transient receptor potential vanilloid 1 (TRPV1) channels were originally described as the receptors of capsaicin, the main constituent of hot chili pepper. Capsaicin 104-113 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 29452097-8 2018 Stimulation of TRPV1 channels induced an influx of Ca2+ into the cells and this rise in intracellular Ca2+ was essential for activating AP-1 in capsaicin or resiniferatoxin-stimulated cells. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 29452097-11 2018 Stimulation of TRPV1 channels with capsaicin increased c-Jun and c-Fos biosynthesis in H2C1 cells. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 29452097-3 2018 Here, we show that stimulation of HEK293 cells expressing TRPV1 channels (H2C1 cells) with capsaicin or the TRPV1 ligand resiniferatoxin activated transcription mediated by the transcription factor AP-1. Capsaicin 91-100 transient receptor potential cation channel subfamily V member 1 Homo sapiens 58-63 29317149-4 2018 In the TRPV1 functional assay, using cells expressed hTRPV1, 37 antagonized capsaicin-induced Ca2+ influx, with an IC50 value of 10.2 nM. Capsaicin 76-85 transient receptor potential cation channel subfamily V member 1 Homo sapiens 53-59 29342359-3 2018 The organic nanoagonists comprise semiconducting polymer nanoparticles (SPNs) and capsaicin (Cap) as the photothermally responsive nanocarrier and the agonist for activation of transient receptor potential cation channel subfamily V member 1 (TRPV1), respectively. Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 177-241 29421065-6 2018 Capsaicin pretreatment induced profound loss of warmth and heat pain sensitivity (pain threshold and supra-threshold ratings) as assessed by quantitative sensory testing, indicative of efficient TRPV1-fiber defunctionalization (all outcomes: P<0.0001). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 195-200 29378958-4 2018 Antagonism of Sig-1R by progesterone results in the down-regulation of TRPV1 expression in the plasma membrane of sensory neurons and, consequently, a decrease in capsaicin-induced nociceptive responses. Capsaicin 163-172 transient receptor potential cation channel subfamily V member 1 Homo sapiens 71-76 29132924-2 2018 Capsaicin, a component of chili pepper, which can stimulate actin remodeling via capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) and anti-inflammatory effects via PPARgamma (peroxisome proliferator-activated receptor-gamma) and LXRalpha (liver X receptor alpha), is a potential candidate to control chlamydial growth in host cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 100-105 29273526-11 2018 SIGNIFICANCE: AM404 gates TRPV1 by interacting with the vanilloid-binding site, and TRPV1 is the main receptor for AM404 in DRG neurons. Capsaicin 56-65 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-31 29191767-5 2018 Substantial views on the capsaicin receptor Transient Receptor Potential Vanilloid V1 (TRPV1), its presence, significance and capsaicin induced mediations have been presented. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 44-85 29339762-1 2018 We previously showed that brown (pre)adipocytes express Trpv1, a capsaicin receptor, and that capsaicin stimulates differentiation of brown preadipocytes in the late stages of brown adipogenesis. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 56-61 29279388-1 2018 The TRPV1 channel is a sensitive detector of pain-producing stimuli, including noxious heat, acid, inflammatory mediators, and vanilloid compounds. Capsaicin 127-136 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 29379817-3 2018 However, involvement of transient receptor potential vanilloid subtype 1 (TRPV1) receptor, which is activated by marijuana, capsaicin, and heat, could fill gaps in existing models, including the enigmatic role of hot water bathing. Capsaicin 124-133 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 29379817-4 2018 We propose that chronic cannabis use decreases TRPV1 signaling and alters gastric motility, and we report the case of a CHS patient whose symptoms improved after topical capsaicin. Capsaicin 170-179 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-52 29239736-6 2018 We applied these findings to develop BODIPY-caged capsaicin, which is well localized to low-polarity intracellular compartments, as a tool to stimulate TRPV1 in live cells in response to blue-green light. Capsaicin 50-59 transient receptor potential cation channel subfamily V member 1 Homo sapiens 152-157 29185571-0 2018 Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 113-118 29185571-1 2018 Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-71 29185571-1 2018 Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 29185571-1 2018 Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 26-71 29185571-1 2018 Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 29185571-4 2018 TRPV1, which can be activated by capsaicin, plays a key role in many biological and physiological processes. Capsaicin 33-42 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 29185571-8 2018 The activation of TRPV1 by capsaicin (25-100 muM) significantly suppressed the migration and invasion of BCPAP cells as well as their adhesion. Capsaicin 27-36 transient receptor potential cation channel subfamily V member 1 Homo sapiens 18-23 29185571-10 2018 Subsequently, the activation of TRPV1 by capsaicin also caused significant inhibition of the expression of MMP-2 and MMP-9. Capsaicin 41-50 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 29185571-11 2018 Moreover, the inhibitory effects of capsaicin on the metastasis of BCPAP cells were abrogated by the pre-treatment of a specific TRPV1 antagonist (capsazepin). Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 129-134 29185571-12 2018 Our results suggest that the activation of TRPV1 by capsaicin is associated with the metastatic inhibition of papillary thyroid cancer BCPAP cells, indicating that targeting of TRPV1 functions remains a feasible strategy for cancer treatment. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-48 29185571-12 2018 Our results suggest that the activation of TRPV1 by capsaicin is associated with the metastatic inhibition of papillary thyroid cancer BCPAP cells, indicating that targeting of TRPV1 functions remains a feasible strategy for cancer treatment. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 177-182 29338036-0 2018 Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 106-111 29338036-6 2018 We found that the synergistic effect could be due to that SMF increased the binding efficiency of capsaicin for the TRPV1 channel. Capsaicin 98-107 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-121 29191767-5 2018 Substantial views on the capsaicin receptor Transient Receptor Potential Vanilloid V1 (TRPV1), its presence, significance and capsaicin induced mediations have been presented. Capsaicin 25-34 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 29191767-7 2018 In this regard, TRPV1 antagonists (especially the competitive antagonist Capsazepine) have been indicated as potential candidates in mitigating or alleviating capsaicin elicited ocular responses. Capsaicin 159-168 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-21 29191767-8 2018 The review overall is a comprehensive perspective of the ocular inflammatory and pharmacological responses generated on exposure to capsaicin and concludes suggesting a possible regulatory framework for relief from the same presumably by the employment of specialized and target specific TRPV1 antagonists. Capsaicin 132-141 transient receptor potential cation channel subfamily V member 1 Homo sapiens 288-293 29059001-6 2018 There was no evidence either that, at fixed temperature, radiofrequency exposure altered the maximal efficacy of the agonist Capsaicin to activate TRPV1. Capsaicin 125-134 transient receptor potential cation channel subfamily V member 1 Homo sapiens 147-152 30209980-0 2018 Effect of single-nucleotide polymorphisms in TRPV1 on burning pain and capsaicin sensitivity in Japanese adults. Capsaicin 71-80 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-50 30209980-1 2018 Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is expressed in the sensory neurons and responds to various noxious stimuli including heat and capsaicin. Capsaicin 182-191 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 30209980-1 2018 Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is expressed in the sensory neurons and responds to various noxious stimuli including heat and capsaicin. Capsaicin 182-191 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 30209980-2 2018 The molecular properties of TRPV1 have been clearly examined; however, there are obvious individual differences in human sensitivity to thermal stimuli and capsaicin. Capsaicin 156-165 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-33 30209980-3 2018 Here, we examined the possibility that different genome sequence of human TRPV1 caused the different sensitivity to heat or capsaicin. Capsaicin 124-133 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 29206105-5 2017 Photon counts and optical fluctuations from coumarin encoded within TRPV1 tetramers correlates with channel activation by capsaicin, providing an optical marker of conformational dynamics at the selectivity filter. Capsaicin 122-131 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-73 28945920-7 2017 The TRPV1-specific agonists capsaicin and resiniferatoxin did not affect the intracellular Ca2+ concentration. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 29129206-2 2017 In sensory neurons, vanilloids like capsaicin induce neurotoxicity by activating TRPV1. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 81-86 29198921-8 2017 It has been recognized that capsaicinoids are the most potential agonists of capsaicin receptor (TRPV1). Capsaicin 28-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-95 29198921-8 2017 It has been recognized that capsaicinoids are the most potential agonists of capsaicin receptor (TRPV1). Capsaicin 28-41 transient receptor potential cation channel subfamily V member 1 Homo sapiens 97-102 29198921-11 2017 Better understanding of the established TRPV1 receptor mechanism as well as exploring other possible receptor mechanism may publicize other new clinical efficacies of capsaicin. Capsaicin 167-176 transient receptor potential cation channel subfamily V member 1 Homo sapiens 40-45 29129206-5 2017 While activation of TRPV1 by the vanilloids capsaicin, resiniferatoxin and anandamide results in calcium-dependent cell death, activation by protons and the oxidant chloramine-T failed to reduce cell viability. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 29180855-10 2017 Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 252-257 28650204-1 2017 RATIONALE: Heightened cough responses to inhaled capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-102 28650204-1 2017 RATIONALE: Heightened cough responses to inhaled capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 104-109 29180855-10 2017 Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-86 29180855-10 2017 Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab. Capsaicin 15-24 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 29180855-10 2017 Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab. Capsaicin 314-323 transient receptor potential cation channel subfamily V member 1 Homo sapiens 46-86 28681979-5 2017 Thus, the vasodilatory role of TRPV1 channels, and their ligand capsaicin, could be a potential therapeutic target for improving vascular function. Capsaicin 64-73 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 28494183-3 2017 Topical capsaicin is a proposed treatment for CHS; it binds TRPV1 with high specificity, impairing substance P signaling in the area postrema and nucleus tractus solitarius via overstimulation of TRPV1. Capsaicin 8-17 transient receptor potential cation channel subfamily V member 1 Homo sapiens 60-65 28494183-3 2017 Topical capsaicin is a proposed treatment for CHS; it binds TRPV1 with high specificity, impairing substance P signaling in the area postrema and nucleus tractus solitarius via overstimulation of TRPV1. Capsaicin 8-17 transient receptor potential cation channel subfamily V member 1 Homo sapiens 196-201 31966488-1 2017 Transient receptor potential vanilloid 1 (TRPV1), the receptor of capsaicin, is a nonselective cation channel that is highly permeable to Ca2+. Capsaicin 66-75 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 31966488-1 2017 Transient receptor potential vanilloid 1 (TRPV1), the receptor of capsaicin, is a nonselective cation channel that is highly permeable to Ca2+. Capsaicin 66-75 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 28892388-2 2017 While radiolabeled resiniferatoxin (RTX) has provided a powerful tool for characterization of vanilloid binding to TRPV1, TRPV1 shows 20-fold weaker binding to the human TRPV1 than to the rodent TRPV1. Capsaicin 94-103 transient receptor potential cation channel subfamily V member 1 Homo sapiens 115-120 29100335-7 2017 Furthermore, it was demonstrated that MDA MB231 and VEGF-A induced sensory neuronal sensitisation in response to capsaicin a TRPV1 agonist. Capsaicin 113-122 transient receptor potential cation channel subfamily V member 1 Homo sapiens 125-130 28095752-1 2017 Transient receptor potential vanilloid 1 (TRPV1) was identified as a receptor of capsaicin, which is a pungent ingredient in hot red peppers. Capsaicin 81-90 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 28520395-1 2017 TRPV1 is a prominent signal integrator of the pain system, known to be activated by vanilloids, a family of endogenous and exogenous pain-evoking molecules, through the vanilloid-binding site (VBS). Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 28389389-1 2017 BACKGROUND: The therapeutic action of capsaicin treatment in patients with idiopathic rhinitis (IR) is based on ablation of the transient receptor potential cation channel subfamily V, receptor 1 (TRPV1)-substance P nociceptive signaling pathway. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 197-202 28658281-1 2017 BACKGROUND: Transient receptor potential cation channel subfamily V member 1 (TRPV1) are sensitive to heat, capsaicin, pungent chemicals and other noxious stimuli. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 12-76 28658281-1 2017 BACKGROUND: Transient receptor potential cation channel subfamily V member 1 (TRPV1) are sensitive to heat, capsaicin, pungent chemicals and other noxious stimuli. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 78-83 28640864-1 2017 There is convincing epidemiological and experimental evidence that capsaicin, a potent natural transient receptor potential cation channel vanilloid member 1 (TRPV1) agonist, has anticancer activity. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 159-164 28640864-9 2017 Capsazepine, a TRPV1 blocker, inhibited both the effect of capsaicin and MRS1477. Capsaicin 59-68 transient receptor potential cation channel subfamily V member 1 Homo sapiens 15-20 28640864-10 2017 Whole-cell patch clamp recordings revealed that capsaicin-evoked TRPV1-mediated current density levels were increased after 3 days incubation with MRS1477 (2 muM). Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 65-70 28062311-6 2017 Capsaicin-induced pain was reduced by the TRPV1 inhibitor BCTC. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 28817717-0 2017 Short Report: TRPV1-polymorphism 1911 A>G alters capsaicin-induced sensory changes in healthy subjects. Capsaicin 52-61 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 28817717-10 2017 CONCLUSION: Presence of homozygous variant TRPV1 genotype (GG) demonstrated less capsaicin-induced warm hypoesthesia in warm-detection and less capsaicin-induced heat pain sensitivity suggesting an altered channel function. Capsaicin 81-90 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-48 28817717-10 2017 CONCLUSION: Presence of homozygous variant TRPV1 genotype (GG) demonstrated less capsaicin-induced warm hypoesthesia in warm-detection and less capsaicin-induced heat pain sensitivity suggesting an altered channel function. Capsaicin 144-153 transient receptor potential cation channel subfamily V member 1 Homo sapiens 43-48 28798481-7 2017 Transient receptor potential vanilloid 1 (TRPV1) ion channel was expressed in hADSC, and the TRPV1 ligand capsaicin (5uM) stimulated proliferation, which could be abrogated by capsazepine. Capsaicin 106-115 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 28798481-7 2017 Transient receptor potential vanilloid 1 (TRPV1) ion channel was expressed in hADSC, and the TRPV1 ligand capsaicin (5uM) stimulated proliferation, which could be abrogated by capsazepine. Capsaicin 106-115 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 28798481-7 2017 Transient receptor potential vanilloid 1 (TRPV1) ion channel was expressed in hADSC, and the TRPV1 ligand capsaicin (5uM) stimulated proliferation, which could be abrogated by capsazepine. Capsaicin 106-115 transient receptor potential cation channel subfamily V member 1 Homo sapiens 93-98 28182310-6 2017 ARMS sensitizes TRPV1 towards capsaicin in transfected HEK 293 cells and in mouse DRG neurons in a PKA-dependent manner. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 16-21 28182310-7 2017 Using a combination of functional imaging and immunocytochemistry, we show that the magnitude of the capsaicin response in DRG neurons depends not only on TRPV1 expression, but on the co-expression of ARMS alongside TRPV1. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 155-160 28182310-7 2017 Using a combination of functional imaging and immunocytochemistry, we show that the magnitude of the capsaicin response in DRG neurons depends not only on TRPV1 expression, but on the co-expression of ARMS alongside TRPV1. Capsaicin 101-110 transient receptor potential cation channel subfamily V member 1 Homo sapiens 216-221 28188907-2 2017 NEO6860 is a TRPV1 antagonist, blocking capsaicin activation of the target, with little or no effect against pH or heat activation. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 13-18 28188907-16 2017 PERSPECTIVE: This first in human study on NEO6860, showed that an antagonist of TRPV1, blocking only the activation by capsaicin has been identified. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 80-85 28515697-5 2017 TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively. Capsaicin 51-60 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 28094445-5 2017 In spinal cord slices, clonidine reduced the frequency of capsaicin-induced miniature EPSCs in the presence of tetrodotoxin and omega-conotoxin-MVIIC, consistent with inhibition of presynaptic TRPV1 channels by alpha2 adrenergic receptors. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 193-198 28095752-1 2017 Transient receptor potential vanilloid 1 (TRPV1) was identified as a receptor of capsaicin, which is a pungent ingredient in hot red peppers. Capsaicin 81-90 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 27979859-0 2017 Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 27979859-11 2017 Taken together, the capsaicin-mediated [Ca2+]cyt increase due to upregulated TRPV1 may be a critical pathogenic mechanism that contributes to augmented Ca2+ influx and excessive PASMC proliferation in patients with IPAH. Capsaicin 20-29 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 27979859-2 2017 Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1) channels to increase cytosolic Ca2+ concentration ([Ca2+]cyt). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-63 27979859-2 2017 Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1) channels to increase cytosolic Ca2+ concentration ([Ca2+]cyt). Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 65-70 27979859-8 2017 Inhibition of TRPV1 (with 5"-IRTX or capsazepine) or knockdown of TRPV1 (with short hairpin RNA) attenuated capsaicin-, acidity-, and osmotic stretch-mediated [Ca2+]cyt increases in IPAH PASMCs. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 27979859-8 2017 Inhibition of TRPV1 (with 5"-IRTX or capsazepine) or knockdown of TRPV1 (with short hairpin RNA) attenuated capsaicin-, acidity-, and osmotic stretch-mediated [Ca2+]cyt increases in IPAH PASMCs. Capsaicin 108-117 transient receptor potential cation channel subfamily V member 1 Homo sapiens 66-71 28352332-6 2017 Electrophysiological analysis revealed that the butanol fraction inhibited capsaicin-induced TRPV1 (84+-8% at -60 mV/86+-1% at 100 mV at 100 microg/ml) and ORAI1 (87+-2% at -120 mV at 100 microg/ml) currents. Capsaicin 75-84 transient receptor potential cation channel subfamily V member 1 Homo sapiens 93-98 28449493-0 2017 TRPV1 polymorphisms influence capsaicin cough sensitivity in men. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 27168163-3 2017 Transient receptor potential vanilloid 1 (TRPV1) on cell membrane is activated by TRPV1 agonist capsaicin resulting in an opening of the channel for calcium influx, which is linked with neurosensory sensations characterized by itching, burning and stinging of skin. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 27168163-3 2017 Transient receptor potential vanilloid 1 (TRPV1) on cell membrane is activated by TRPV1 agonist capsaicin resulting in an opening of the channel for calcium influx, which is linked with neurosensory sensations characterized by itching, burning and stinging of skin. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 27168163-3 2017 Transient receptor potential vanilloid 1 (TRPV1) on cell membrane is activated by TRPV1 agonist capsaicin resulting in an opening of the channel for calcium influx, which is linked with neurosensory sensations characterized by itching, burning and stinging of skin. Capsaicin 96-105 transient receptor potential cation channel subfamily V member 1 Homo sapiens 82-87 27055401-5 2017 RESULTS: The intracellular free calcium ion concentration and current densities increased with TRPV1 channel activator capsaicin (0.01 mM), but they decreased with the TRPV1 blocker capsazepine (0.1 mM), Se, cisplatin, and Se + cisplatin incubations. Capsaicin 119-128 transient receptor potential cation channel subfamily V member 1 Homo sapiens 95-100 27992447-13 2016 In addition, sperm cells were able to migrate toward a gradient of capsaicin, a specific agonist of TRPV1, whilst capsazepine, a specific agonist of TRPV1, blocked this effect. Capsaicin 67-76 transient receptor potential cation channel subfamily V member 1 Homo sapiens 100-105 27821307-6 2017 To prove sensing functionality of the tissue, we use topical applications of capsaicin, an agonist of transient receptor protein-vanilloid 1 (TRPV1) channel, and quantify calcium currents resulting from variations of Ca++ concentration in DRG neurons innervating our model. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 102-140 27821307-6 2017 To prove sensing functionality of the tissue, we use topical applications of capsaicin, an agonist of transient receptor protein-vanilloid 1 (TRPV1) channel, and quantify calcium currents resulting from variations of Ca++ concentration in DRG neurons innervating our model. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 142-147 28076819-3 2017 Our BRET study also confirmed that: (1) capsaicin and heat promoted distinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca2+-bound CaM but not Ca2+-free CaM were preassociated in resting live cells, while capsaicin activation induced both the formation of more TRPV1/CaM complexes and conformational changes. Capsaicin 40-49 transient receptor potential cation channel subfamily V member 1 Homo sapiens 295-300 28076819-3 2017 Our BRET study also confirmed that: (1) capsaicin and heat promoted distinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca2+-bound CaM but not Ca2+-free CaM were preassociated in resting live cells, while capsaicin activation induced both the formation of more TRPV1/CaM complexes and conformational changes. Capsaicin 239-248 transient receptor potential cation channel subfamily V member 1 Homo sapiens 144-149 29238714-5 2017 Besides, NsAchE-negative but capsaicin-sensitive subbasal nerve (leash) fibers formed thick mesh-like structure showing close interconnections and exhibit both isolectin B4- and transient receptor potential vanilloid channel 1- (TRPV1-) positive. Capsaicin 29-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 229-234 28879245-6 2017 Capsaicin is the primary agonist for TRPV1 and has been used previously in relatively low doses (0.025% to 0.075%) as a therapeutic for a variety of pain disorders, including postherpetic neuralgia and osteoarthritis; however, analgesic efficacy remains equivocal. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 28008282-5 2016 Activation of TRPV1 by its ligand capsaicin was associated with the growth inhibition of some cancer cell types; however, the signaling components involved are complex. Capsaicin 34-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 28008282-6 2016 In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 34-39 28008282-6 2016 In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin. Capsaicin 49-58 transient receptor potential cation channel subfamily V member 1 Homo sapiens 246-251 28008282-7 2016 Activation of TRPV1 by capsaicin caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 27627464-8 2016 This in turn decreases rate and amplitude of TRPV1-mediated cytosolic calcium, which inhibits capsaicin-induced inward current and neuronal firing. Capsaicin 94-103 transient receptor potential cation channel subfamily V member 1 Homo sapiens 45-50 27734949-3 2016 This deletion not only inactivates the CTNS gene but also extends into the non-coding region upstream of the start codon of the TRPV1 gene, encoding the capsaicin- and heat-sensitive ion channel TRPV1. Capsaicin 153-162 transient receptor potential cation channel subfamily V member 1 Homo sapiens 128-133 27758864-2 2016 We hypothesized that polymorphic variants of transient receptor potential vanilloid-1 (TRPV1) would be uniquely responsive to insoluble coal fly ash compared with the prototypical soluble agonist capsaicin. Capsaicin 196-205 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 27758864-4 2016 The TRPV1-I315M and -T469I variants were more responsive to capsaicin and coal fly ash. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 27722942-0 2016 Quantitative characterization of capsaicin-induced TRPV1 ion channel activation in HEK293 cells by impedance spectroscopy. Capsaicin 33-42 transient receptor potential cation channel subfamily V member 1 Homo sapiens 51-56 27722942-6 2016 TRPV1 channel activation by capsaicin resulted in a reproducible impedance decrease. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 27809268-3 2016 Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel that is enriched in the terminals of certain nociceptors. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-37 27729033-3 2016 Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-132 27729033-3 2016 Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-139 27729033-3 2016 Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-132 27729033-3 2016 Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers. Capsaicin 11-14 transient receptor potential cation channel subfamily V member 1 Homo sapiens 134-139 26988467-1 2016 BACKGROUND: At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density. Capsaicin 54-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 39-45 28195064-3 2016 Therefore, the aims of this study were to evaluate the effects of epinephrine and norepinephrine on TRPV1 desensitization induced by repeated applications of capsaicin and to assess what would be the involvement of the major alpha1, alpha2 and beta adrenergic receptor subtypes. Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 100-105 27250983-2 2016 Other studies showed that ATP activates the capsaicin-sensitive TRPV1 channel via P2Y receptors. Capsaicin 44-53 transient receptor potential cation channel subfamily V member 1 Homo sapiens 64-69 27586050-7 2016 In contrast, myristicin inhibited neutrophil [Ca(2+)]i flux stimulated by fMLF and IL-8 and inhibited capsaicin-induced Ca(2+) influx in TRPV1-transfected HEK293 cells. Capsaicin 102-111 transient receptor potential cation channel subfamily V member 1 Homo sapiens 137-142 27734949-3 2016 This deletion not only inactivates the CTNS gene but also extends into the non-coding region upstream of the start codon of the TRPV1 gene, encoding the capsaicin- and heat-sensitive ion channel TRPV1. Capsaicin 153-162 transient receptor potential cation channel subfamily V member 1 Homo sapiens 195-200 27606946-2 2016 Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been extensively characterized; however, detailed information on the binding mode of other vanilloids remains lacking. Capsaicin 131-140 transient receptor potential cation channel subfamily V member 1 Homo sapiens 31-36 27391380-6 2016 Mechanistic studies identified the ion channels TRPV1 and TRPA1 as targets of capsaicin in pepper spray, and of the tear gas agents chloroacetophenone, CS, and CR. Capsaicin 78-87 transient receptor potential cation channel subfamily V member 1 Homo sapiens 48-53 27094759-1 2016 BACKGROUND: Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese. Capsaicin 147-156 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-123 26984967-5 2016 RESULTS: Seven days after it was administered to tissues outside the calvaria, BoNT-A inhibited responses of C-type meningeal nociceptors to stimulation of their intracranial dural receptive fields with the TRPV1 agonist capsaicin and the TRPA1 agonist mustard oil. Capsaicin 221-230 transient receptor potential cation channel subfamily V member 1 Homo sapiens 207-212 27485456-8 2016 Expression of TRPV1 is reduced in patients with idiopathic rhinitis after capsaicin treatment. Capsaicin 74-83 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 27339229-1 2016 There is enormous interest toward vanilloid agonists of the pain receptor TRPV1 in analgesic therapy, but the mechanisms of their sensory neuron-blocking effects at high or repeated doses are still a matter of debate. Capsaicin 34-43 transient receptor potential cation channel subfamily V member 1 Homo sapiens 74-79 27339229-2 2016 Our results have demonstrated that capsaicin and resiniferatoxin form nanomolar complexes with calmodulin, and competitively inhibit TRPV1-calmodulin interaction. Capsaicin 35-44 transient receptor potential cation channel subfamily V member 1 Homo sapiens 133-138 27094759-1 2016 BACKGROUND: Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 68-116 27094759-1 2016 BACKGROUND: Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 118-123 27563913-1 2016 Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca(2+) permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX). Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 27563913-1 2016 Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca(2+) permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX). Capsaicin 158-167 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 27180305-1 2016 Vanilloids including capsaicin and resiniferatoxin are potent transient receptor potential vanilloid type 1 (TRPV1) agonists. Capsaicin 21-30 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-107 27180305-1 2016 Vanilloids including capsaicin and resiniferatoxin are potent transient receptor potential vanilloid type 1 (TRPV1) agonists. Capsaicin 21-30 transient receptor potential cation channel subfamily V member 1 Homo sapiens 109-114 27180305-2 2016 TRPV1 overstimulation selectively ablates capsaicin-sensitive sensory neurons in animal models in vivo. Capsaicin 42-51 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 27180305-9 2016 We assume that the low vanilloid-sensitivity of prostate and breast cancer cells is associated with low expression levels of TRPV1, since ectopic TRPV1 expression rendered them susceptible to the cytotoxic effect of vanilloids evidenced by plateau-type Ca(2+) signals, mitochondrial Ca(2+) accumulation and Na(+)- and Ca(2+)-dependent membrane disorganization. Capsaicin 23-32 transient receptor potential cation channel subfamily V member 1 Homo sapiens 125-130 27697214-5 2016 In fact, capsaicin and its analog capsinoids, representative agonists of TRPV1, mimic the effects of cold to decrease body fatness through the activation and recruitment of BAT. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 73-78 26932896-2 2016 We conducted studies to determine if the presence of acid in the mucosa/submucosa and direct activation of TRPV1 by capsaicin elicited symptoms in normal healthy subjects. Capsaicin 116-125 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 27438088-1 2016 OBJECTIVE: Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis. Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 122-171 27438088-1 2016 OBJECTIVE: Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis. Capsaicin 188-197 transient receptor potential cation channel subfamily V member 1 Homo sapiens 173-178 27455231-8 2016 This review summarizes the historical background, source, structure and analogues of capsaicin, and capsaicin-triggered TRPV1 signaling and desensitization processes. Capsaicin 100-109 transient receptor potential cation channel subfamily V member 1 Homo sapiens 120-125 26883442-9 2016 It is found that activating TRPV1 by capsaicin inhibits VSMC foam cell formation and the accompanied migration through rescuing the SIRT1 and suppressing NF-kappaB signaling. Capsaicin 37-46 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-33 26942555-4 2016 Several compounds were found to activate TRPV1 channels, and in particular, derivatives 1 and 10 behaved as TRPV1 agonists endowed with good efficacy as compared to capsaicin. Capsaicin 165-174 transient receptor potential cation channel subfamily V member 1 Homo sapiens 41-46 27298359-7 2016 These results not only validate our current working model for capsaicin activation of TRPV1 but also should help guide the design of drug candidate compounds for this important pain sensor. Capsaicin 62-71 transient receptor potential cation channel subfamily V member 1 Homo sapiens 86-91 27347918-2 2016 Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-75 27347918-2 2016 Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 27347918-7 2016 Capsaicin activates TRPV1, which modulates the permeability of tight junctions (TJ) by regulating the expression and function of putative intercellular adhesion molecules in an ERK (extracelluar signal-regulated kinase) -dependent manner. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 20-25 26967694-1 2016 Transient receptor potential vanilloid 1 (TRPV1) is a polymodal receptor activated by capsaicin, heat, and acid, which plays critical roles in thermosensation and pain. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 26967694-1 2016 Transient receptor potential vanilloid 1 (TRPV1) is a polymodal receptor activated by capsaicin, heat, and acid, which plays critical roles in thermosensation and pain. Capsaicin 86-95 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 27143360-0 2016 Tyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics. Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 24-29 27159637-5 2016 In comparison to capsaicin, coadministration of 1 and capsaicin increased the half-maximal effective concentration (EC50) of capsaicin-activated TRPV1 currents as shown by a right shift in the dose-response curve, whereas coadministration of 1 with protons failed to inhibit the proton-induced current. Capsaicin 54-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 145-150 27159637-5 2016 In comparison to capsaicin, coadministration of 1 and capsaicin increased the half-maximal effective concentration (EC50) of capsaicin-activated TRPV1 currents as shown by a right shift in the dose-response curve, whereas coadministration of 1 with protons failed to inhibit the proton-induced current. Capsaicin 54-63 transient receptor potential cation channel subfamily V member 1 Homo sapiens 145-150 27159637-6 2016 Moreover, preadministration of 1, but not 2, inhibited both capsaicin- and proton-induced TRPV1 currents, which might involve channel desensitization. Capsaicin 60-69 transient receptor potential cation channel subfamily V member 1 Homo sapiens 90-95 27159637-7 2016 Taken together, 1 and 2 may share the same binding site with capsaicin and act as partial agonists (antagonists) of TRPV1. Capsaicin 61-70 transient receptor potential cation channel subfamily V member 1 Homo sapiens 116-121 27163769-1 2016 PURPOSE: The heat-sensitive transient receptor potential vanilloid type-1 (TRPV1) channel (i.e., capsaicin [CAP] receptor) is upregulated in numerous cancers. Capsaicin 97-106 transient receptor potential cation channel subfamily V member 1 Homo sapiens 28-73 26859646-6 2016 RESULTS: Activation of hTRPA1 by carvacrol and hTRPV1 by capsaicin produced a QX-314-independent reduction of sodium current amplitudes. Capsaicin 57-66 transient receptor potential cation channel subfamily V member 1 Homo sapiens 47-53 26859646-8 2016 Five and 30 mM QX-314 activated hTRPV1 via mechanisms involving the intracellular vanilloid-binding domain and hTRPA1 via unknown mechanisms independent of intracellular cysteins. Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 32-38 27163769-1 2016 PURPOSE: The heat-sensitive transient receptor potential vanilloid type-1 (TRPV1) channel (i.e., capsaicin [CAP] receptor) is upregulated in numerous cancers. Capsaicin 97-106 transient receptor potential cation channel subfamily V member 1 Homo sapiens 75-80 26756551-10 2016 Eact activation of the TRPV1 channel was severely attenuated by mutations disrupting the capsaicin-binding sites. Capsaicin 89-98 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-28 26934446-5 2016 Capsaicin-evoked TRPV1 currents in dorsal root ganglion (DRG) neurons were examined by the patch-clamp technique. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 17-22 25598150-8 2016 PEA only slightly enhanced 2-AG activation of TRPV1 channels, but significantly increased 2-AG-induced TRPV1 desensitization to capsaicin (IC50 from 0.75 +- 0.04 to 0.45 +- 0.02 muM, with PEA 2 muM). Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 103-108 26525975-1 2016 Transient receptor transient receptor potential vanilloid 1 (TRPV1) is a Ca(2+)-permeable channel gated by oxidative stress and capsaicin (CAP) and modulated by melatonin (MEL) and capsazepine (CPZ). Capsaicin 128-137 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 26525975-1 2016 Transient receptor transient receptor potential vanilloid 1 (TRPV1) is a Ca(2+)-permeable channel gated by oxidative stress and capsaicin (CAP) and modulated by melatonin (MEL) and capsazepine (CPZ). Capsaicin 139-142 transient receptor potential cation channel subfamily V member 1 Homo sapiens 61-66 26360809-2 2016 These compounds were investigated for antagonism of hTRPV1 activation by capsaicin and acid in vitro. Capsaicin 73-82 transient receptor potential cation channel subfamily V member 1 Homo sapiens 52-58 26645885-0 2016 Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8. Capsaicin 22-31 transient receptor potential cation channel subfamily V member 1 Homo sapiens 95-100 26645885-1 2016 Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (>42 C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity. Capsaicin 156-165 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-40 26645885-1 2016 Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (>42 C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity. Capsaicin 156-165 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 26645885-1 2016 Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (>42 C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity. Capsaicin 156-165 transient receptor potential cation channel subfamily V member 1 Homo sapiens 174-179 26645885-5 2016 hTRPV1 currents activated by heat and capsaicin were inhibited by menthol, whereas hTRPM8 currents activated by cold and menthol were similarly inhibited by capsaicin. Capsaicin 38-47 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-6 26795113-3 2016 These compounds were evaluated for antagonism of hTRPV1 activation by capsaicin and the ability to inhibit Ovine COX-1 and human recombinant COX-2 in vitro. Capsaicin 70-79 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-55 26621124-8 2016 Activation and inhibition of TRPV1 receptors (via capsaicin 1muM and capsazepine 10muM, respectively) did not influence basal synaptic transmission in CA1 and CA3 regions of control slices, however, capsaicin increased and capsazepine decreased synaptic transmission in both regions in tissues from epileptic animals. Capsaicin 50-59 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 26621124-8 2016 Activation and inhibition of TRPV1 receptors (via capsaicin 1muM and capsazepine 10muM, respectively) did not influence basal synaptic transmission in CA1 and CA3 regions of control slices, however, capsaicin increased and capsazepine decreased synaptic transmission in both regions in tissues from epileptic animals. Capsaicin 199-208 transient receptor potential cation channel subfamily V member 1 Homo sapiens 29-34 26738986-0 2016 Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca(2+) influx through transient receptor potential V1 (TRPV1) channels. Capsaicin 41-50 transient receptor potential cation channel subfamily V member 1 Homo sapiens 95-126 26738986-0 2016 Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca(2+) influx through transient receptor potential V1 (TRPV1) channels. Capsaicin 41-50 transient receptor potential cation channel subfamily V member 1 Homo sapiens 128-133 26738986-6 2016 However, treatment with THAM (pH 8.5) following capsaicin application elicited a profound, long-lasting increase in [Ca(2+)]i that was completely inhibited by the TRPV1 antagonist capsazepine. Capsaicin 48-57 transient receptor potential cation channel subfamily V member 1 Homo sapiens 163-168 27771922-3 2016 In addition to the anti-inflammatory and analgesic properties of capsaicin largely recognized via, mainly, interaction with the TRPV1, the effects of capsaicin on different cell signalling pathways will be further discussed here. Capsaicin 65-74 transient receptor potential cation channel subfamily V member 1 Homo sapiens 128-133 26884754-11 2016 Psychophysical studies with capsaicin are consistent with recent findings that have identified TRPV1 channel modulation by phosphorylation and interactions with membrane inositol phospholipids. Capsaicin 28-37 transient receptor potential cation channel subfamily V member 1 Homo sapiens 95-100 26490461-1 2016 Some cation permeable ligand-gated ion channels, including the capsaicin-sensitive TRPV1, have been reported to exhibit a time-dependent increase in permeability to large inorganic cations during sustained activation, a phenomenon termed "pore dilation." Capsaicin 63-72 transient receptor potential cation channel subfamily V member 1 Homo sapiens 83-88 26490461-3 2016 However, our experiments employing whole cell patch clamp photometry and single channel recordings to directly measure relative Ca(2+) current in TRPV1 expressing HEK293 cells show that relative Ca(2+) influx remains constant for the duration of capsaicin-evoked channel activation. Capsaicin 246-255 transient receptor potential cation channel subfamily V member 1 Homo sapiens 146-151 26719417-0 2016 Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin. Capsaicin 78-87 transient receptor potential cation channel subfamily V member 1 Homo sapiens 14-19 26719417-4 2016 The recent cryo-electron microscopy structure of TRPV1 only provides a coarse characterization of the location of capsaicin (CAPS) and resiniferatoxin (RTX). Capsaicin 114-123 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 26719417-4 2016 The recent cryo-electron microscopy structure of TRPV1 only provides a coarse characterization of the location of capsaicin (CAPS) and resiniferatoxin (RTX). Capsaicin 125-129 transient receptor potential cation channel subfamily V member 1 Homo sapiens 49-54 28115879-2 2016 Capsaicin, one of several capsaicinoid compounds, is a potent TRPV1 agonist. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-67 25854794-1 2016 BACKGROUND: Topical high-dose capsaicin acting on TRPV1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (NP). Capsaicin 30-39 transient receptor potential cation channel subfamily V member 1 Homo sapiens 50-55 26648574-0 2016 Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 77-82 26648574-5 2016 Furthermore, activation of TRPV1 by capsaicin was shown to induce growth inhibition of 5637 cells in which TRPV1 was highly expressed, while the growth of T24 cells, which express TRPV1 at low levels, was not affected. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 27-32 26648574-5 2016 Furthermore, activation of TRPV1 by capsaicin was shown to induce growth inhibition of 5637 cells in which TRPV1 was highly expressed, while the growth of T24 cells, which express TRPV1 at low levels, was not affected. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 26648574-5 2016 Furthermore, activation of TRPV1 by capsaicin was shown to induce growth inhibition of 5637 cells in which TRPV1 was highly expressed, while the growth of T24 cells, which express TRPV1 at low levels, was not affected. Capsaicin 36-45 transient receptor potential cation channel subfamily V member 1 Homo sapiens 107-112 27160991-8 2016 CAP inhibits the metabolic activity of malignant hematological cells through non-TRPV1-dependent mechanisms. Capsaicin 0-3 transient receptor potential cation channel subfamily V member 1 Homo sapiens 81-86 26881438-6 2016 RESULTS: Capsaicin, a TRPV1 agonist, stimulates both the cough and swallowing reflexes. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 22-27 27398080-6 2016 METHODS: We developed a flow through biosensor with human cells expressing both the TRPV1, a calcium ion channel which responds to capsaicin, and the fluorescent intracellular calcium ion reporter, YC3.6. Capsaicin 131-140 transient receptor potential cation channel subfamily V member 1 Homo sapiens 84-89 27160991-0 2016 Capsaicin-Induced Death of Human Haematological Malignant Cell Lines Is Independent of TRPV1 Activation. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 87-92 28115879-2 2016 Capsaicin, one of several capsaicinoid compounds, is a potent TRPV1 agonist. Capsaicin 26-38 transient receptor potential cation channel subfamily V member 1 Homo sapiens 62-67 26578888-13 2015 Responses in some MEN significantly decreased after perfusion of TTX, low Ca(++)/high Mg(++) Krebs solution, capsaicin induced nerve defunctionalization and capsazepine indicating the involvement of TRPV1 expressing extrinsic mechanosensitive nerves. Capsaicin 109-118 transient receptor potential cation channel subfamily V member 1 Homo sapiens 199-204 26114340-6 2015 By applying capsaicin onto the skin, TRPV1 channels are activated and a CGRP-mediated increase in dermal blood flow can be quantified with laser Doppler perfusion imaging. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 37-42 26424893-12 2015 Significance statement: In this original work, it is shown for the first time that paclitaxel activates peripheral sensory and spinal neurons directly and sensitizes these cells to transient receptor potential vanilloid subtype 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species. Capsaicin 247-256 transient receptor potential cation channel subfamily V member 1 Homo sapiens 181-229 26827596-5 2015 Capsaicin, an agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), has been shown to activate the peripheral sensory C-fibers. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 25-65 26827596-5 2015 Capsaicin, an agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), has been shown to activate the peripheral sensory C-fibers. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 67-72 25978942-1 2015 BACKGROUND: Capsaicin specifically activates, and then gradually exhausts, the transient receptor potential vanilloid type 1 (TRPV1) receptor, a key receptor in neuropathic pain. Capsaicin 12-21 transient receptor potential cation channel subfamily V member 1 Homo sapiens 126-131 25978942-8 2015 METHODS: Capsaicin .075% cream was applied to both halves of each participant"s upper lip, inducing pain via stimulation of the transient receptor potential vanilloid 1 (TRPV1, capsaicin) receptor, then removed after 5 minutes or when participants reported a burning pain of 8/10, whichever came first. Capsaicin 9-18 transient receptor potential cation channel subfamily V member 1 Homo sapiens 170-175 26247812-2 2015 Capsaicin binds to the vanilloid receptor TRPV1, which plays a role in coordinating chemical and physical painful stimuli. Capsaicin 0-9 transient receptor potential cation channel subfamily V member 1 Homo sapiens 42-47 25703814-1 2015 TRPV1 is a Ca2+ permeable channel and gated by noxious heat, oxidative stress and capsaicin (CAP). Capsaicin 82-91 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 25703814-1 2015 TRPV1 is a Ca2+ permeable channel and gated by noxious heat, oxidative stress and capsaicin (CAP). Capsaicin 93-96 transient receptor potential cation channel subfamily V member 1 Homo sapiens 0-5 26048309-7 2015 Moreover, the VBC, as well as, each one of the B vitamins independently reduced the capsaicin-induced calcium responses in HEK 293 cells transiently transfected with the human TRPV1 channels. Capsaicin 84-93 transient receptor potential cation channel subfamily V member 1 Homo sapiens 176-181 26424893-12 2015 Significance statement: In this original work, it is shown for the first time that paclitaxel activates peripheral sensory and spinal neurons directly and sensitizes these cells to transient receptor potential vanilloid subtype 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species. Capsaicin 247-256 transient receptor potential cation channel subfamily V member 1 Homo sapiens 231-236 25754030-1 2015 The heat- and capsaicin-sensitive transient receptor potential vanilloid 1 ion channel (TRPV1) is regulated by plasma membrane phosphoinositides. Capsaicin 14-23 transient receptor potential cation channel subfamily V member 1 Homo sapiens 88-93 25943423-4 2015 Functional blockade of TRPV1-positive nociceptors by high-concentration capsaicin (verified by loss of heat pain) significantly reduced pain ratings to high frequency stimulation by 47% (P < 0.001), homotopic pain-long-term potentiation by 71% (P < 0.01), heterotopic pain-long-term potentiation by 92% (P < 0.001) and the area of secondary hyperalgesia by 76% (P < 0.001). Capsaicin 72-81 transient receptor potential cation channel subfamily V member 1 Homo sapiens 23-28 26054320-4 2015 Specific inhibitors of TRPA1 (HC- 030031) and a specific activator of TRPV1 (capsaicin) were used to block or activate TRPA1 and TRPV1, respectively. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 70-75 26054320-4 2015 Specific inhibitors of TRPA1 (HC- 030031) and a specific activator of TRPV1 (capsaicin) were used to block or activate TRPA1 and TRPV1, respectively. Capsaicin 77-86 transient receptor potential cation channel subfamily V member 1 Homo sapiens 129-134 25754030-5 2015 We conclude that PI(4,5)P2 and potentially its precursor PI(4)P are positive cofactors for TRPV1, acting via direct interaction with the channel, and their depletion by Ca(2+)-induced activation of phospholipase Cdelta isoforms (PLCdelta) limits channel activity during capsaicin-induced desensitization. Capsaicin 270-279 transient receptor potential cation channel subfamily V member 1 Homo sapiens 91-96 26170176-1 2015 The TRPV1 cation channel is a polymodal nociceptor that is activated by heat and ligands such as capsaicin and is highly sensitive to changes in extracellular pH. Capsaicin 97-106 transient receptor potential cation channel subfamily V member 1 Homo sapiens 4-9 26170176-2 2015 In the body core, where temperature is usually stable and capsaicin is normally absent, H(+) released in response to ischemia, tissue injury, or inflammation is the best-known endogenous TRPV1 agonist, activating the channel to mediate pain and vasodilation. Capsaicin 58-67 transient receptor potential cation channel subfamily V member 1 Homo sapiens 187-192