PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22459208-3 2012 It has been reported that the anti-diabetic drug metformin and some natural compounds, such as quercetin, genistein, capsaicin and green tea polyphenol epigallocatechin gallate (EGCG), can activate AMPK and inhibit cancer cell growth. Capsaicin 117-126 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 198-202 25138094-7 2014 In addition, several other drugs, such as resveratrol, berberine, statins, epigallocatechin gallate (EGCG) and capsaicin, have provided a similar capacity for tumor inhibition, and the anti-cancer effects of most of them were mainly the result of AMPK activation. Capsaicin 111-120 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 247-251 31095448-6 2019 In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK). Capsaicin 43-52 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 79-130 17404062-0 2007 Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells. Capsaicin 41-50 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 15-19 17404062-4 2007 In this article, we have investigated the effects of capsaicin on apoptosis in relation to AMPK activation in colon cancer cell. Capsaicin 53-62 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 91-95 17404062-6 2007 Concomitantly, the activation of AMPK and the increased expression of the inactive form of acetyl-CoA carboxylase (ACC) were detected in capsaicin-treated colon cancer cells. Capsaicin 137-146 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 33-37 17404062-7 2007 We showed that both capsaicin and 5"-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR), an AMPK activator possess the AMPK-activating capacity as well as apoptosis-inducing properties. Capsaicin 20-29 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 102-106 17404062-7 2007 We showed that both capsaicin and 5"-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR), an AMPK activator possess the AMPK-activating capacity as well as apoptosis-inducing properties. Capsaicin 20-29 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 129-133 17404062-8 2007 Evidence of the association between AMPK activation and the increased apoptosis in HT-29 colon cancer cells by capsaicin treatment, and further findings of the correlation of the activated AMPK and the elevated apoptosis by cotreatment of AICAR and capsaicin support AMPK as an important component of apoptosis, as well as a possible target of cancer control. Capsaicin 111-120 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 36-40 17404062-8 2007 Evidence of the association between AMPK activation and the increased apoptosis in HT-29 colon cancer cells by capsaicin treatment, and further findings of the correlation of the activated AMPK and the elevated apoptosis by cotreatment of AICAR and capsaicin support AMPK as an important component of apoptosis, as well as a possible target of cancer control. Capsaicin 249-258 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 189-193 17404062-8 2007 Evidence of the association between AMPK activation and the increased apoptosis in HT-29 colon cancer cells by capsaicin treatment, and further findings of the correlation of the activated AMPK and the elevated apoptosis by cotreatment of AICAR and capsaicin support AMPK as an important component of apoptosis, as well as a possible target of cancer control. Capsaicin 249-258 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 189-193 35214061-0 2022 The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells. Capsaicin 29-38 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 49-53 35214061-3 2022 We found that capsaicin activated AMP-activated kinase (AMPK) and promoted cell death in the LKB1-expressing prostate cancer cell lines LNCaP and PC3, but not in the liver kinase B1 (LKB1)-null cell line DU-145. Capsaicin 14-23 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 34-54 35214061-3 2022 We found that capsaicin activated AMP-activated kinase (AMPK) and promoted cell death in the LKB1-expressing prostate cancer cell lines LNCaP and PC3, but not in the liver kinase B1 (LKB1)-null cell line DU-145. Capsaicin 14-23 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 56-60 35214061-4 2022 Capsaicin treatment stimulated LKB1 phosphorylation and activated AMPK in LKB1-expressing cells. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 66-70 35214061-5 2022 In addition, LKB1 silencing in LNCaP and PC3 cells abrogated capsaicin-induced AMPK activation, while the overexpression of LKB1 by lentiviral infection in DU-145 cells induced capsaicin-triggered AMPK phosphorylation. Capsaicin 61-70 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 79-83 35214061-7 2022 Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 187-191 35214061-8 2022 Altogether, our results showed that capsaicin affected AMPK activity in an LKB1- and TRPV1-dependent fashion, linking TRPV1 with cell fate. Capsaicin 36-45 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 55-59 33885140-0 2021 Retraction: Capsaicin inhibits migration and invasion via the AMPK/NF-kB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression. Capsaicin 12-21 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 62-66 32614062-0 2020 Expression of Concern: Capsaicin inhibits migration and invasion via the AMPK/NF-kB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression. Capsaicin 23-32 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 73-77 31095448-6 2019 In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK). Capsaicin 43-52 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 132-136 31095448-8 2019 Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways. Capsaicin 48-57 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 245-249 29152112-0 2017 Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 103-107 29152112-6 2017 Moreover, capsaicin singly and the combination of capsaicin and sorafenib induce AMPK activation and Acetyl CoA carboxylase phosphorylation in HCC cells. Capsaicin 10-19 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 29152112-6 2017 Moreover, capsaicin singly and the combination of capsaicin and sorafenib induce AMPK activation and Acetyl CoA carboxylase phosphorylation in HCC cells. Capsaicin 50-59 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 81-85 29152112-7 2017 Knocking down of AMPK by selective siRNA abrogates capsaicin-induced Akt inhibition, suggesting the involvement of AMPK in the antiproliferative effect. Capsaicin 51-60 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 17-21 29152112-7 2017 Knocking down of AMPK by selective siRNA abrogates capsaicin-induced Akt inhibition, suggesting the involvement of AMPK in the antiproliferative effect. Capsaicin 51-60 protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens 115-119