PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22665354-7	2012	Furthermore, capsaicin suppressed the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.	Capsaicin	13-22	cyclin dependent kinase 2	Homo sapiens	212-217	
22462738-11	2012	Furthermore, capsaicin inhibits the proliferation of 5637 bladder carcinoma cells by cycle arrest with the inhibition of CDK2, CDK4 and CDK6.	Capsaicin	13-22	cyclin dependent kinase 2	Homo sapiens	121-125	
20646592-5	2010	And the expressions of cell cycle protein P53, P21, CDK2 were detected by Western blot after the treatment of capsaicin.	Capsaicin	110-119	cyclin dependent kinase 2	Homo sapiens	52-56	
20646592-11	2010	After a 48-hour treatment with capsaicin, the expressions of P53 and P21 were up-regulated in contrary to the expression of CDK2.	Capsaicin	31-40	cyclin dependent kinase 2	Homo sapiens	124-128	
20646592-12	2010	CONCLUSION: Capsaicin induces the cell cycle arrest of bladder cancer RT4 cells G(0)/G(1) phase and growth inhibition via TRPV1 receptor by modulating the expression of P53, P21 and CDK2.	Capsaicin	12-21	cyclin dependent kinase 2	Homo sapiens	182-186	
16942782-6	2006	Capsaicin induced G0-G1 phase arrest underwent the promotion of p53 and p21, which is an inhibitor of Cdk2 and cyclin E complex before leading to the inhibitions of both compounds.	Capsaicin	0-9	cyclin dependent kinase 2	Homo sapiens	102-106	
16827131-3	2006	Capsaicin-induced G0/G1-phase arrest involved the suppression of CDK2 and the cyclin E complex, which are check-point enzymes for cells moving from G0/G1- to S-phase.	Capsaicin	0-9	cyclin dependent kinase 2	Homo sapiens	65-69