PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15977164-8 2005 Furthermore, microinjections of BDNF into the spinal cord or release of endogenous BDNF by intraplantar injection of capsaicin activated ERK phosphorylation in TrkB-containing STT neurons. Capsaicin 117-126 brain-derived neurotrophic factor Rattus norvegicus 83-87 19524560-6 2009 Moreover, BDNF treatment increased the amplitude of the response to both AITC and capsaicin. Capsaicin 82-91 brain-derived neurotrophic factor Rattus norvegicus 10-14 19139871-12 2009 Capsaicin has a long-lasting desensitizing action, brain-derived neurotrophic factor, and tumor necrosis factor-alpha, a short-lasting one. Capsaicin 0-9 brain-derived neurotrophic factor Rattus norvegicus 51-117 11000490-0 2000 Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia and spinal cord. Capsaicin 0-9 brain-derived neurotrophic factor Rattus norvegicus 21-54 15120568-2 2004 In this study, we have measured the effects of various neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and -4) on recombinant rat VR1-mediated intracellular calcium rise in response to capsaicin in VR1/C6 cells. Capsaicin 224-233 brain-derived neurotrophic factor Rattus norvegicus 91-124 11404434-2 2001 Here we show that BDNF is released in the rat isolated dorsal horn after chemical stimulation by capsaicin or electrical stimulation of dorsal roots. Capsaicin 97-106 brain-derived neurotrophic factor Rattus norvegicus 18-22 11404434-3 2001 Capsaicin superfusion (1-100 microm) induced a dose-dependent release of BDNF, measured using ELISA. Capsaicin 0-9 brain-derived neurotrophic factor Rattus norvegicus 73-77 11404434-4 2001 The highest dose of capsaicin also induced a depletion of BDNF protein in the dorsal horn. Capsaicin 20-29 brain-derived neurotrophic factor Rattus norvegicus 58-62 11404434-11 2001 This upregulated BDNF content in the DRG and increased the capsaicin-evoked release of BDNF. Capsaicin 59-68 brain-derived neurotrophic factor Rattus norvegicus 87-91 11000490-2 2000 The percentage of BDNF-immunoreactive neurons in the L5 DRG was found to increase significantly 1 day after capsaicin injection. Capsaicin 108-117 brain-derived neurotrophic factor Rattus norvegicus 18-22 11000490-8 2000 The mechanism by which capsaicin induces changes in expression of BDNF in DRG neurons and the functional significance of the rapid increase in BDNF levels in the DRG is discussed briefly. Capsaicin 23-32 brain-derived neurotrophic factor Rattus norvegicus 66-70 30365624-6 2018 However, an increased expression of COX-2 and decreased expression of BDNF was observed in the hippocampus of animals that received capsaicin or SB-334867-A (80 nM) plus capsaicin. Capsaicin 132-141 brain-derived neurotrophic factor Rattus norvegicus 70-74 10619644-6 1999 BDNF gene expression in these neurons was down-regulated after application of capsaicin to the sciatic nerve. Capsaicin 78-87 brain-derived neurotrophic factor Rattus norvegicus 0-4 35563108-7 2022 Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate. Capsaicin 15-24 brain-derived neurotrophic factor Rattus norvegicus 59-63 35563108-7 2022 Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate. Capsaicin 15-24 brain-derived neurotrophic factor Rattus norvegicus 133-137 9502206-0 1998 Brain derived neurotrophic factor, but not nerve growth factor, regulates capsaicin sensitivity of rat vagal ganglion neurones. Capsaicin 74-83 brain-derived neurotrophic factor Rattus norvegicus 0-33 9502206-5 1998 As some vagal ganglion neurones exhibit responses to brain derived neurotrophic factor (BDNF), we grew cells in BDNF (1 microg/ml) and found that the capsaicin sensitivity was now apparent at 5 days. Capsaicin 150-159 brain-derived neurotrophic factor Rattus norvegicus 53-86 9502206-5 1998 As some vagal ganglion neurones exhibit responses to brain derived neurotrophic factor (BDNF), we grew cells in BDNF (1 microg/ml) and found that the capsaicin sensitivity was now apparent at 5 days. Capsaicin 150-159 brain-derived neurotrophic factor Rattus norvegicus 88-92 9502206-5 1998 As some vagal ganglion neurones exhibit responses to brain derived neurotrophic factor (BDNF), we grew cells in BDNF (1 microg/ml) and found that the capsaicin sensitivity was now apparent at 5 days. Capsaicin 150-159 brain-derived neurotrophic factor Rattus norvegicus 112-116 9502206-6 1998 Therefore BDNF but not NGF, regulates capsaicin sensitivity in adult rat vagal ganglion neurone cultures. Capsaicin 38-47 brain-derived neurotrophic factor Rattus norvegicus 10-14 30809460-6 2019 Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release. Capsaicin 36-45 brain-derived neurotrophic factor Rattus norvegicus 148-152 30809460-6 2019 Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release. Capsaicin 36-45 brain-derived neurotrophic factor Rattus norvegicus 206-210 30365624-6 2018 However, an increased expression of COX-2 and decreased expression of BDNF was observed in the hippocampus of animals that received capsaicin or SB-334867-A (80 nM) plus capsaicin. Capsaicin 170-179 brain-derived neurotrophic factor Rattus norvegicus 70-74 30365624-7 2018 Meanwhile, orexin-A (40 pM) attenuated the effects of capsaicin on the expression of COX-2 and BDNF. Capsaicin 54-63 brain-derived neurotrophic factor Rattus norvegicus 95-99 27078694-2 2016 Capsaicin stimulation of afferent fibres was also shown to result in the release of BDNF into the spinal cord. Capsaicin 0-9 brain-derived neurotrophic factor Rattus norvegicus 84-88 30013731-0 2018 Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats. Capsaicin 18-27 brain-derived neurotrophic factor Rattus norvegicus 68-101 30013731-8 2018 Results: The data indicated an increase in COX-2 and decrease in BDNF immuno-reactivity in the Vc of capsaicin, and capsaicin- pretreated with SB-334867-A (80 nM), groups of rat. Capsaicin 101-110 brain-derived neurotrophic factor Rattus norvegicus 65-69 30013731-9 2018 However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM). Capsaicin 23-32 brain-derived neurotrophic factor Rattus norvegicus 46-50 30013731-10 2018 Conclusions: Overall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats. Capsaicin 75-84 brain-derived neurotrophic factor Rattus norvegicus 161-165 27818188-11 2017 BDNF enhanced, rather than attenuated, capsaicin-induced EMR and ERK/pERK expression. Capsaicin 39-48 brain-derived neurotrophic factor Rattus norvegicus 0-4 27078694-6 2016 Furthermore, intrathecal administration of exogenous BDNF not only produced mechanical hyperalgesia but also significantly blocked the inhibitory effect of capsaicin. Capsaicin 156-165 brain-derived neurotrophic factor Rattus norvegicus 53-57