PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25217963-7 2014 In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation. Capsaicin 149-158 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 53-57 25217963-0 2014 Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-kappaB signaling pathway. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 128-132 25217963-7 2014 In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation. Capsaicin 3-12 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 53-57 25217963-7 2014 In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation. Capsaicin 3-12 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 121-125 25217963-7 2014 In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation. Capsaicin 149-158 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 121-125 25217963-9 2014 In addition, capsaicin-activated AMPK induced the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65. Capsaicin 13-22 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 33-37 25217963-11 2014 These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression. Capsaicin 37-46 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 149-153 25217963-11 2014 These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression. Capsaicin 37-46 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 168-172 30899201-16 2019 In addition, pharmacological inhibition of AMPK with dorsomorphin (compound C) as well as knock down by siRNA of AMPK or its upstream kinase LKB1, abolished the synergy of docetaxel and capsaicin. Capsaicin 186-195 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 43-47 30987128-0 2019 Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 53-57 30987128-7 2019 This effect of capsaicin was prevented by dorsomorphin and GW9662, pharmacological inhibitors of AMPK and PPARgamma, respectively. Capsaicin 15-24 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 97-101 30987128-8 2019 In addition, capsaicin activated AMPK and inhibited the AKT/mTOR pathway, major regulators of hepatic lipogenesis. Capsaicin 13-22 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 33-37 24005536-0 2013 Capsaicin induces apoptosis in human osteosarcoma cells through AMPK-dependent and AMPK-independent signaling pathways. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 64-68 24005536-0 2013 Capsaicin induces apoptosis in human osteosarcoma cells through AMPK-dependent and AMPK-independent signaling pathways. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 83-87 24005536-3 2013 In the current study, we observed that capsaicin-induced growth inhibition and apoptosis in cultured osteosarcoma cells (U2OS and MG63), which were associated with a significant AMP-activated protein kinase (AMPK) activation. Capsaicin 39-48 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 178-206 24005536-3 2013 In the current study, we observed that capsaicin-induced growth inhibition and apoptosis in cultured osteosarcoma cells (U2OS and MG63), which were associated with a significant AMP-activated protein kinase (AMPK) activation. Capsaicin 39-48 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 208-212 24005536-4 2013 AMPK inhibition by compound C or RNA interference suppressed capsaicin-induced cytotoxicity, while AMPK activators (AICAR and A769662) promoted osteosarcoma cell death. Capsaicin 61-70 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 0-4 24005536-5 2013 For the mechanism study, we found that AMPK activation was required for capsaicin-induced mTORC1 (mTOR complex 1) inhibition, B cell lymphoma 2 (Bcl-2) downregulation and Bax upregulation in MG63 cells. Capsaicin 72-81 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 39-43 24005536-6 2013 Capsaicin administration induced p53 activation, mitochondrial translocation and Bcl-2 killer association, such effects were dependent on AMPK activation. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 138-142 24005536-7 2013 Interestingly, we observed a significant pro-apoptotic c-Jun NH2-terminal kinases activation by capsaicin in MG63 cells, which appeared to be AMPK independent. Capsaicin 96-105 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 142-146 24005536-9 2013 Molecular studies revealed that capsaicin activated AMPK-dependent and AMPK-independent signalings to mediate cell apoptosis. Capsaicin 32-41 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 52-56 24005536-9 2013 Molecular studies revealed that capsaicin activated AMPK-dependent and AMPK-independent signalings to mediate cell apoptosis. Capsaicin 32-41 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 71-75 35405615-13 2022 Capsaicin restored AMPK phosphorylation and IHG-inhibited TRPV1 expression. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 19-23 35405615-15 2022 CONCLUSION: Capsaicin elevates SIRT1 levels through TRPV1/(Ca2+)i/CaMKII/AMPK pathway and suppresses IHG-mediated endothelial cell senescence. Capsaicin 12-21 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 73-77 31712319-7 2020 In addition, HFD also inhibits AMPK activity to reduce SIRT3 expression, which could be reversed by capsaicin. Capsaicin 100-109 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 31-35 31324733-0 2019 Capsaicin inhibits the migration and invasion via the AMPK/NF-kappaB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression. Capsaicin 0-9 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 54-58 31324733-6 2019 In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65. Capsaicin 13-22 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 155-159 31324733-7 2019 Overall, these results revealed that Capsaicin can inhibit the migration and invasion of ESCC cells via the AMPK/NF-kappaB signaling pathway. Capsaicin 37-46 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 108-112 30899201-0 2019 Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase. Capsaicin 35-44 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 141-161 30899201-16 2019 In addition, pharmacological inhibition of AMPK with dorsomorphin (compound C) as well as knock down by siRNA of AMPK or its upstream kinase LKB1, abolished the synergy of docetaxel and capsaicin. Capsaicin 186-195 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 113-117 27196129-7 2017 Furthermore, the anti-invasive activity of arvanil, olvanil and capsaicin was mediated by the AMPK pathway. Capsaicin 64-73 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 94-98 27196129-8 2017 Depletion of AMPK levels by siRNA methodology abrogated the anti-invasive activity of arvanil, olvanil and capsaicin. Capsaicin 107-116 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 13-17