PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25997958-0 2015 Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways. Capsaicin 26-35 mitogen-activated protein kinase 8 Homo sapiens 134-137 31095448-6 2019 In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK). Capsaicin 43-52 mitogen-activated protein kinase 8 Homo sapiens 147-170 31095448-6 2019 In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK). Capsaicin 43-52 mitogen-activated protein kinase 8 Homo sapiens 172-175 31095448-8 2019 Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways. Capsaicin 48-57 mitogen-activated protein kinase 8 Homo sapiens 217-220 27729033-0 2016 Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 77-80 27729033-10 2016 Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9. Capsaicin 9-12 mitogen-activated protein kinase 8 Homo sapiens 41-44 27729033-10 2016 Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9. Capsaicin 115-118 mitogen-activated protein kinase 8 Homo sapiens 72-75 29048662-8 2017 Moreover, our results revealed that the anticancer effects induced by capsaicin on OS cell lines involved multiple MAPK signaling pathways as indicated by inactivation of the ERK1/2 and p38 pathways and activation of the JNK pathway. Capsaicin 70-79 mitogen-activated protein kinase 8 Homo sapiens 221-224 25997958-5 2015 We also found that capsaicin induced JNK and p38 MAPK phosphorylation. Capsaicin 19-28 mitogen-activated protein kinase 8 Homo sapiens 37-40 25997958-6 2015 JNK and p38 MAPK inhibitor effectively blocked capsaicin-induced SMMC-7721 cell apoptosis. Capsaicin 47-56 mitogen-activated protein kinase 8 Homo sapiens 0-3 25997958-7 2015 In addition, NAC completely blocked phosphorylation of JNK and p38 MAPK induced by capsaicin. Capsaicin 83-92 mitogen-activated protein kinase 8 Homo sapiens 55-58 25997958-8 2015 Our results indicate that capsaicin induced in SMMC-7721 cell apoptosis through generation of intracellular ROS and activation of JNK and p38 MAPK pathways. Capsaicin 26-35 mitogen-activated protein kinase 8 Homo sapiens 130-133 24419059-2 2014 Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3.6PL cells. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 35-51 24419059-15 2014 Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1. Capsaicin 41-50 mitogen-activated protein kinase 8 Homo sapiens 61-64 24419059-2 2014 Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3.6PL cells. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 53-56 24419059-5 2014 Antioxidants tiron and PEG-catalase blocked capsaicin-mediated JNK/FOXO/BIM activation and protected the cells from apoptosis. Capsaicin 44-53 mitogen-activated protein kinase 8 Homo sapiens 63-66 24419059-10 2014 JNK inhibitor attenuated the phosphorylation of FOXO-1, activation of BIM, and abrogated capsaicin-induced apoptosis. Capsaicin 89-98 mitogen-activated protein kinase 8 Homo sapiens 0-3 24337453-6 2014 Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 84-87 19002586-7 2008 Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 50-53 21462327-7 2011 Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 287-293 19139269-11 2009 DHC induced rapid and high-sustained c-Jun NH(2)-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK) activation, but capsaicin induced transient activation of JNK/ERK. Capsaicin 131-140 mitogen-activated protein kinase 8 Homo sapiens 173-176 19139269-15 2009 Our results indicate that the differential responses of capsaicin and DHC for cell protection are caused by the extent of the UPR and autophagy that are both regulated by the level of JNK and ERK activation. Capsaicin 56-65 mitogen-activated protein kinase 8 Homo sapiens 184-187 19002586-7 2008 Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 58-61 19002586-7 2008 Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis. Capsaicin 109-118 mitogen-activated protein kinase 8 Homo sapiens 50-53 19002586-7 2008 Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis. Capsaicin 109-118 mitogen-activated protein kinase 8 Homo sapiens 58-61 9580328-5 1998 Capsaicin and resiniferatoxin were found to activate both isoforms of c-jun-NH2-kinase (JNK), with a maximal activity after 30 min of treatment. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 70-86 17828457-7 2007 Pharmacological inhibition of JNK kinase, as well as inhibition of ROS by the reducing agent N-acetylcysteine, prevented ceramide accumulation and capsaicin-induced cell death. Capsaicin 147-156 mitogen-activated protein kinase 8 Homo sapiens 30-33 17828457-11 2007 We conclude that capsaicin induces apoptosis in PC-3 cells via ROS generation, JNK activation, ceramide accumulation, and second, ERK activation. Capsaicin 17-26 mitogen-activated protein kinase 8 Homo sapiens 79-82 16123700-4 2005 The phosphorylation of p38 MAPK and c-Jun NH2-terminal kinase (JNK) were detected after capsaicin stimulation. Capsaicin 88-97 mitogen-activated protein kinase 8 Homo sapiens 36-61 16123700-4 2005 The phosphorylation of p38 MAPK and c-Jun NH2-terminal kinase (JNK) were detected after capsaicin stimulation. Capsaicin 88-97 mitogen-activated protein kinase 8 Homo sapiens 63-66 12478662-0 2003 Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells. Capsaicin 62-71 mitogen-activated protein kinase 8 Homo sapiens 9-14 12478662-6 2003 In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs). Capsaicin 23-32 mitogen-activated protein kinase 8 Homo sapiens 62-101 12478662-7 2003 The use of kinase inhibitors and overexpression of dominant-negative forms of MAPKs demonstrated a role of JNK-1 and p38, but not that of ERKs, in apoptosis induced by capsaicin in H-ras-transformed MCF10A cells. Capsaicin 168-177 mitogen-activated protein kinase 8 Homo sapiens 107-112 17828457-0 2007 Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Capsaicin 21-30 mitogen-activated protein kinase 8 Homo sapiens 116-119 9580328-5 1998 Capsaicin and resiniferatoxin were found to activate both isoforms of c-jun-NH2-kinase (JNK), with a maximal activity after 30 min of treatment. Capsaicin 0-9 mitogen-activated protein kinase 8 Homo sapiens 88-91