PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33062722-6	2020	Treatment with AM251 and AM630 (CB1/2 antagonists) abolished capsaicin-induced beneficial effects, indicating the existence of a functional crosstalk between CB and TRPV1.	Capsaicin	61-70	cannabinoid receptor 1 (brain)	Mus musculus	32-37	
29991708-9	2019	The capsaicin-induced aversion in the plus-maze test was enhanced by WIN55212-2 and blocked by pretreatment with vanilloid antagonist capsazepine or the CB1 receptor antagonist rimonabant, demonstrating an interaction between the endocannabinoid and endovanilloid systems in CNS.	Capsaicin	4-13	cannabinoid receptor 1 (brain)	Mus musculus	153-156	
21249195-7	2011	The specific antagonist of cannabinoid receptor type 1 (CB1), AM 251, was also able to reduce the inhibitory effect of capsaicin on LA-LTP, suggesting that stimulation of TRPV1 provokes the generation of anandamide in the brain which seems to inhibit NO synthesis.	Capsaicin	119-128	cannabinoid receptor 1 (brain)	Mus musculus	27-59	
27178246-7	2016	This pro-nociceptive phenotype was accompanied by increases in capsaicin-evoked Fos-like immunoreactive (FLI) cells in spinal dorsal horn regions implicated in nociceptive processing and was attenuated by CB1 (AM251) and TRPV1 (AMG9810) antagonists.	Capsaicin	63-72	cannabinoid receptor 1 (brain)	Mus musculus	205-208	
25088915-4	2014	We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are present in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased the number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration).	Capsaicin	253-262	cannabinoid receptor 1 (brain)	Mus musculus	14-17	
21868092-7	2011	CB1-/- and CB1/CB2 double -/- mice equally displayed increased sensitivity to mAEA (100 muM) and a sensitizing effect to capsaicin, in contrast to wildtypes.	Capsaicin	121-130	cannabinoid receptor 1 (brain)	Mus musculus	0-3	
21868092-7	2011	CB1-/- and CB1/CB2 double -/- mice equally displayed increased sensitivity to mAEA (100 muM) and a sensitizing effect to capsaicin, in contrast to wildtypes.	Capsaicin	121-130	cannabinoid receptor 1 (brain)	Mus musculus	11-14	
29046638-6	2017	While intra-dPAG AEA did not change acute pain, local injections of capsaicin or WIN induced a marked TRPV1- and CB1-dependent antinociceptive effect, respectively.	Capsaicin	68-77	cannabinoid receptor 1 (brain)	Mus musculus	113-116	
22982038-7	2013	Since we have recently shown the involvement of cannabinoid CB1 receptors in the mediation of capsaicin-induced inhibitory effects on LA-LTP ([23] Zschenderlein et al., 2011), it is reasonable to assume that the OLDA-induced enhancement of LA-LTP after the forced swim test can be attributed to the up-regulation of TRPV1 and the action of ligands such as anandamide on TRPV1.	Capsaicin	94-103	cannabinoid receptor 1 (brain)	Mus musculus	60-63	
16553616-14	2006	Experiments on capsaicin-induced CGRP release in tissue from CB1-/- mice ruled out a CB1-mediated effect.	Capsaicin	15-24	cannabinoid receptor 1 (brain)	Mus musculus	61-64	
11786475-0	2002	CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord.	Capsaicin	46-55	cannabinoid receptor 1 (brain)	Mus musculus	0-5	
11786475-2	2002	We have investigated a possible modulatory role for Type 1 Cannabinoid receptors (CB(1)) on the release of excitatory transmitter Substance P from the adult mouse spinal cord after stimulation of nociceptor terminals by capsaicin.	Capsaicin	220-229	cannabinoid receptor 1 (brain)	Mus musculus	82-87	
11786475-6	2002	Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM).	Capsaicin	86-95	cannabinoid receptor 1 (brain)	Mus musculus	15-20	
11786475-6	2002	Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM).	Capsaicin	160-169	cannabinoid receptor 1 (brain)	Mus musculus	15-20	
11786475-7	2002	Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation.	Capsaicin	56-65	cannabinoid receptor 1 (brain)	Mus musculus	14-19	
11786475-7	2002	Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation.	Capsaicin	56-65	cannabinoid receptor 1 (brain)	Mus musculus	100-105	
12040079-0	2002	Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism.	Capsaicin	53-62	cannabinoid receptor 1 (brain)	Mus musculus	94-97