PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33062722-6 2020 Treatment with AM251 and AM630 (CB1/2 antagonists) abolished capsaicin-induced beneficial effects, indicating the existence of a functional crosstalk between CB and TRPV1. Capsaicin 61-70 cannabinoid receptor 1 (brain) Mus musculus 32-37 29991708-9 2019 The capsaicin-induced aversion in the plus-maze test was enhanced by WIN55212-2 and blocked by pretreatment with vanilloid antagonist capsazepine or the CB1 receptor antagonist rimonabant, demonstrating an interaction between the endocannabinoid and endovanilloid systems in CNS. Capsaicin 4-13 cannabinoid receptor 1 (brain) Mus musculus 153-156 21249195-7 2011 The specific antagonist of cannabinoid receptor type 1 (CB1), AM 251, was also able to reduce the inhibitory effect of capsaicin on LA-LTP, suggesting that stimulation of TRPV1 provokes the generation of anandamide in the brain which seems to inhibit NO synthesis. Capsaicin 119-128 cannabinoid receptor 1 (brain) Mus musculus 27-59 27178246-7 2016 This pro-nociceptive phenotype was accompanied by increases in capsaicin-evoked Fos-like immunoreactive (FLI) cells in spinal dorsal horn regions implicated in nociceptive processing and was attenuated by CB1 (AM251) and TRPV1 (AMG9810) antagonists. Capsaicin 63-72 cannabinoid receptor 1 (brain) Mus musculus 205-208 25088915-4 2014 We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are present in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased the number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration). Capsaicin 253-262 cannabinoid receptor 1 (brain) Mus musculus 14-17 21868092-7 2011 CB1-/- and CB1/CB2 double -/- mice equally displayed increased sensitivity to mAEA (100 muM) and a sensitizing effect to capsaicin, in contrast to wildtypes. Capsaicin 121-130 cannabinoid receptor 1 (brain) Mus musculus 0-3 21868092-7 2011 CB1-/- and CB1/CB2 double -/- mice equally displayed increased sensitivity to mAEA (100 muM) and a sensitizing effect to capsaicin, in contrast to wildtypes. Capsaicin 121-130 cannabinoid receptor 1 (brain) Mus musculus 11-14 29046638-6 2017 While intra-dPAG AEA did not change acute pain, local injections of capsaicin or WIN induced a marked TRPV1- and CB1-dependent antinociceptive effect, respectively. Capsaicin 68-77 cannabinoid receptor 1 (brain) Mus musculus 113-116 22982038-7 2013 Since we have recently shown the involvement of cannabinoid CB1 receptors in the mediation of capsaicin-induced inhibitory effects on LA-LTP ([23] Zschenderlein et al., 2011), it is reasonable to assume that the OLDA-induced enhancement of LA-LTP after the forced swim test can be attributed to the up-regulation of TRPV1 and the action of ligands such as anandamide on TRPV1. Capsaicin 94-103 cannabinoid receptor 1 (brain) Mus musculus 60-63 16553616-14 2006 Experiments on capsaicin-induced CGRP release in tissue from CB1-/- mice ruled out a CB1-mediated effect. Capsaicin 15-24 cannabinoid receptor 1 (brain) Mus musculus 61-64 11786475-0 2002 CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord. Capsaicin 46-55 cannabinoid receptor 1 (brain) Mus musculus 0-5 11786475-2 2002 We have investigated a possible modulatory role for Type 1 Cannabinoid receptors (CB(1)) on the release of excitatory transmitter Substance P from the adult mouse spinal cord after stimulation of nociceptor terminals by capsaicin. Capsaicin 220-229 cannabinoid receptor 1 (brain) Mus musculus 82-87 11786475-6 2002 Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM). Capsaicin 86-95 cannabinoid receptor 1 (brain) Mus musculus 15-20 11786475-6 2002 Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM). Capsaicin 160-169 cannabinoid receptor 1 (brain) Mus musculus 15-20 11786475-7 2002 Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation. Capsaicin 56-65 cannabinoid receptor 1 (brain) Mus musculus 14-19 11786475-7 2002 Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation. Capsaicin 56-65 cannabinoid receptor 1 (brain) Mus musculus 100-105 12040079-0 2002 Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. Capsaicin 53-62 cannabinoid receptor 1 (brain) Mus musculus 94-97