PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21745629-9 2011 Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity. Capsaicin 94-103 MAPK associated protein 1 Homo sapiens 59-64 21745629-0 2011 Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells. Capsaicin 0-9 MAPK associated protein 1 Homo sapiens 53-86 21745629-2 2011 In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages. Capsaicin 79-88 MAPK associated protein 1 Homo sapiens 186-219 21745629-2 2011 In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages. Capsaicin 79-88 MAPK associated protein 1 Homo sapiens 221-226 21745629-3 2011 To investigate whether capsaicin ameliorates palmitate-induced MIP-1 and IL-8 gene expressions, we treated THP-1 cells with palmitate in the presence or absence of capsaicin and measured MIP-1 and IL-8 by real-time polymerase chain reaction. Capsaicin 23-32 MAPK associated protein 1 Homo sapiens 63-68 21745629-4 2011 To elucidate the mechanism by which capsaicin effects on palmitate-induced MIP-1 and IL-8 gene expressions, we performed immunoblotting with stress kinase-related antibodies and measured palmitate oxidation and palmitate oxidation-related gene expression. Capsaicin 36-45 MAPK associated protein 1 Homo sapiens 75-80 21745629-6 2011 Treatment with capsaicin or FFA oxidation stimulators inhibited palmitate-induced MIP-1 and IL-8 expressions in THP-1 macrophages. Capsaicin 15-24 MAPK associated protein 1 Homo sapiens 82-87