PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22233274-11 2012 Capsaicin-induced endothelial cell proliferation was completely blocked by coadministration of CGRP and NK1 receptor antagonists, indicating that both CGRP and substance P may contribute to angiogenesis in this model of synovitis. Capsaicin 0-9 tachykinin receptor 1 Rattus norvegicus 104-116 23911956-7 2013 Moreover, nociception induced by either capsaicin or AITC was reduced by the desensitisation of TRPV1-positive sensory fibres with resiniferatoxin (73 +- 18 and 76 +- 15% inhibitions, respectively) and by the NK1 receptor antagonist aprepitant (56 +- 5 and 53 +- 8% inhibitions, respectively). Capsaicin 40-49 tachykinin receptor 1 Rattus norvegicus 209-221 23172292-9 2013 Additionally, we show that, after a noxious stimulus (intradermal capsaicin injection), these NK-1r on pyramidal neurons were internalized, providing evidence that these neurons become responsive to peripheral noxious stimulation. Capsaicin 66-75 tachykinin receptor 1 Rattus norvegicus 94-99 21430411-0 2011 Effects of systemic capsaicin treatment on TRPV1 and Tachykinin NK(1) receptor distribution and function in the nucleus of the solitary tract of the adult rat. Capsaicin 20-29 tachykinin receptor 1 Rattus norvegicus 64-78 22215714-1 2012 Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism. Capsaicin 240-249 tachykinin receptor 1 Rattus norvegicus 316-337 21430411-2 2011 We have previously shown that systemic capsaicin administration to neonatal rats evokes profound long-term alterations in transient receptor potential vanilloid 1 (TRPV1)- and neurokinin 1 (NK(1)) receptor-mediated respiratory responses in the commissural nucleus of the solitary tract (cNTS). Capsaicin 39-48 tachykinin receptor 1 Rattus norvegicus 176-205 21430411-7 2011 Systemic capsaicin pretreatment significantly (p < 0.05) reduced the density of both [(125)I]Bolton-Hunter SP binding sites (NK(1) receptors) and NK(1) receptor immunoreactivity in the cNTS, but did not alter the respiratory responses evoked by microinjection of [Sar(9), Met(O(2))(11)]SP and septide into this region. Capsaicin 9-18 tachykinin receptor 1 Rattus norvegicus 128-163 21430411-8 2011 These studies show that systemic capsaicin administration reduces NK(1) receptor density in the cNTS without adversely affecting NK(1) receptor function at this site. Capsaicin 33-42 tachykinin receptor 1 Rattus norvegicus 66-80 19152548-0 2009 Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor. Capsaicin 0-9 tachykinin receptor 1 Rattus norvegicus 136-164 18798491-12 2008 CONCLUSION: Pretreatment with capsaicin can attenuate myocardial ischemia-reperfusion injury, of which the likely mechanism is by stimulating capsaicin receptor or TRPV1 and further activating substance P receptor in the rat in vivo. Capsaicin 30-39 tachykinin receptor 1 Rattus norvegicus 193-213 18809416-0 2008 Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons. Capsaicin 74-83 tachykinin receptor 1 Rattus norvegicus 28-49 18809416-1 2008 The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmunoassay. Capsaicin 139-148 tachykinin receptor 1 Rattus norvegicus 71-92 18809416-1 2008 The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmunoassay. Capsaicin 139-148 tachykinin receptor 1 Rattus norvegicus 94-99 18809416-8 2008 These findings suggest that the activation of NK-1R by its agonist, by sensitizing the TRPV1 through the PKC phosphorylation of TRPV1, may play a role in the enhancement of the capsaicin-evoked SP release from cultured rat DRG neurons. Capsaicin 177-186 tachykinin receptor 1 Rattus norvegicus 46-51 18222611-3 2008 NMDA alone or when co-administered with D-serine failed to induce NK1r internalization, whereas activation of spinal TRPV1 receptors by capsaicin resulted in a notable NK1r internalization. Capsaicin 136-145 tachykinin receptor 1 Rattus norvegicus 168-172 17182914-5 2007 The increased responses to NMDA after capsaicin were attenuated by iontophoretic application of the selective NK-1 receptor antagonist L-733,060. Capsaicin 38-47 tachykinin receptor 1 Rattus norvegicus 110-123 17182914-6 2007 Similarly to capsaicin, iontophoretic application of the selective NK-1 receptor agonist, [Sar(9),Met(O(2))(11)]-substance P (SM-SP), increased the spontaneous discharge rate and NMDA-evoked responses of on cells by >100% of control values. Capsaicin 13-22 tachykinin receptor 1 Rattus norvegicus 67-80 16788306-0 2006 The NK1 receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons. Capsaicin 46-55 tachykinin receptor 1 Rattus norvegicus 4-16 16399878-5 2006 Injection of the TRPV1 agonist capsaicin into the pancreatic duct induced endocytosis of the neurokinin 1 receptor in spinal neurons in the dorsal horn (T10), indicative of SP release upon stimulation of pancreatic sensory nerves. Capsaicin 31-40 tachykinin receptor 1 Rattus norvegicus 93-114 15494187-0 2004 Beta adrenergic inhibition of capsaicin-induced, NK1 receptor-mediated nerve growth factor biosynthesis in rat skin. Capsaicin 30-39 tachykinin receptor 1 Rattus norvegicus 49-61 16056236-7 2005 The NK1 receptor antagonists GR205171 (100 microM) and SDZ NKT 376 (1 mM) also reduced the response to capsaicin (from 1.75+/-0.14 to 0.46+/-0.08; n = 6, and from 1.85+/-0.13 to 0.48+/-0.05; n = 5, respectively), indicating that capsaicin acts via TRPV1 in series with NK(1). Capsaicin 103-112 tachykinin receptor 1 Rattus norvegicus 4-16 16056236-7 2005 The NK1 receptor antagonists GR205171 (100 microM) and SDZ NKT 376 (1 mM) also reduced the response to capsaicin (from 1.75+/-0.14 to 0.46+/-0.08; n = 6, and from 1.85+/-0.13 to 0.48+/-0.05; n = 5, respectively), indicating that capsaicin acts via TRPV1 in series with NK(1). Capsaicin 229-238 tachykinin receptor 1 Rattus norvegicus 4-16 15908510-10 2005 The naloxone-induced internalization was blocked by NK1r antagonist L-703,606 [cis-2-(diphenylmethyl)-N-[(2-iodophenyl)methyl]-1 azabicyclo[2.2.2]octan-3-amine] or pretreatment with capsaicin, confirming that the internalization is due to the endogenous SP release from the primary afferents. Capsaicin 182-191 tachykinin receptor 1 Rattus norvegicus 52-56 15774269-4 2005 L-732138 (NK1 receptor antagonist) or SR-48968 (NK2 receptor antagonist) pretreatment reduced capsaicin-enhanced hypotension, bronchoconstriction, plasma extravasation, and plasma NO level. Capsaicin 94-103 tachykinin receptor 1 Rattus norvegicus 10-22 15494187-9 2004 The results show that topical administration of capsaicin causes a primarily NK1 receptor-dependent increase in the NGF content of rat skin, which is susceptible to inhibition by beta adrenergic agonists. Capsaicin 48-57 tachykinin receptor 1 Rattus norvegicus 77-89 15067207-0 2004 Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression. Capsaicin 9-18 tachykinin receptor 1 Rattus norvegicus 110-131 15067207-1 2004 Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. Capsaicin 159-168 tachykinin receptor 1 Rattus norvegicus 57-78 15067207-1 2004 Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. Capsaicin 159-168 tachykinin receptor 1 Rattus norvegicus 80-85 14706790-4 2004 Intrathecal administration of the neurokinin-1 receptor antagonist, (3aR,7aR)-7,7-diphenyl-2-(1-imino-2(2-methoxyphenyl)-ethyl) perhydroisoindol-4-1 hydrochloride or the N-methyl-D-aspartate receptor antagonist, DL-2-amino-5-phosphonovaleric acid, both antagonists of the action of primary afferent neurotransmitters, markedly attenuated the inhibition of bradykinin-induced plasma extravasation produced by both intrathecal nicotine and intraplantar capsaicin.Conversely, intrathecal administration of an alpha-adrenoceptor antagonist, phentolamine or an opioid receptor antagonist, naloxone, to block descending antinociceptive controls, which provide inhibitory input to primary afferent nociceptors, enhanced the action of both nicotine and capsaicin. Capsaicin 451-460 tachykinin receptor 1 Rattus norvegicus 34-55 15067207-1 2004 Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. Capsaicin 170-173 tachykinin receptor 1 Rattus norvegicus 57-78 15067207-1 2004 Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death. Capsaicin 170-173 tachykinin receptor 1 Rattus norvegicus 80-85 15067207-2 2004 SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration. Capsaicin 31-34 tachykinin receptor 1 Rattus norvegicus 180-185 15067207-2 2004 SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration. Capsaicin 31-34 tachykinin receptor 1 Rattus norvegicus 210-215 15067207-8 2004 By contrast, NK-1R mRNA levels were increased in thymocytes from CPS-treated rats. Capsaicin 65-68 tachykinin receptor 1 Rattus norvegicus 13-18 15067207-9 2004 Exogenous SP administration augmented PPT-A, SP and NK-1R thymocyte expression in CPS-treated rats, and this enhancement was antagonized by SR140333 administration. Capsaicin 82-85 tachykinin receptor 1 Rattus norvegicus 52-57 15067207-10 2004 Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells. Capsaicin 84-87 tachykinin receptor 1 Rattus norvegicus 182-187 15067207-10 2004 Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells. Capsaicin 142-151 tachykinin receptor 1 Rattus norvegicus 182-187 14568027-5 2003 Incubating the root with capsaicin produced NK1R internalization in the ipsilateral dorsal horn that was abolished when capsazepine or lidocaine was included in, or when Ca(2+) was omitted from, the medium surrounding the root. Capsaicin 25-34 tachykinin receptor 1 Rattus norvegicus 44-48 14568027-2 2003 To determine whether these two actions have different mechanisms, we measured neurokinin 1 receptor (NK1R) internalization in rat spinal cord slices elicited by incubating the whole slice or just the dorsal root with capsaicin. Capsaicin 217-226 tachykinin receptor 1 Rattus norvegicus 78-99 14568027-2 2003 To determine whether these two actions have different mechanisms, we measured neurokinin 1 receptor (NK1R) internalization in rat spinal cord slices elicited by incubating the whole slice or just the dorsal root with capsaicin. Capsaicin 217-226 tachykinin receptor 1 Rattus norvegicus 101-105 14568027-3 2003 NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine. Capsaicin 60-69 tachykinin receptor 1 Rattus norvegicus 0-4 14568027-3 2003 NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine. Capsaicin 60-69 tachykinin receptor 1 Rattus norvegicus 91-95 12699788-0 2003 Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord. Capsaicin 21-30 tachykinin receptor 1 Rattus norvegicus 62-83 12699788-3 2003 Our objective was to compare substance P release and NK1 receptor internalization produced by capsaicin in rat spinal cord slices. Capsaicin 94-103 tachykinin receptor 1 Rattus norvegicus 53-65 12699788-9 2003 The correlation was good for laminae I (R(2)=0.82) and III (R(2)=0.78), but it was poor (R(2)=0.35) for lamina IV because NK1 receptor internalization kept on increasing at high concentrations of capsaicin, whereas substance P release decreased. Capsaicin 196-205 tachykinin receptor 1 Rattus norvegicus 122-134 14625038-4 2003 Capsaicin induced an increase in the frequency of miniature excitatory postsynaptic currents in 73% of lamina I and 43% of lamina III/IV neurons expressing NK1-receptor indicating that these neurons receive direct input from capsaicin and heat sensitive nociceptors. Capsaicin 0-9 tachykinin receptor 1 Rattus norvegicus 156-168 10202860-2 1999 The capsaicin (500 nmol)-induced antidiuresis was inhibited by pretreatment with CP96345 (30 nmol, a neurokinin-1-receptor antagonist), but not by that with phenoxybenzamine (20 nmol, an alpha-adrenoceptor antagonist), timolol (100 nmol, a beta-adrenoceptor antagonist) or atropine (300 nmol, a muscarinic antagonist) into the hypothalamic supraoptic nucleus (SON). Capsaicin 4-13 tachykinin receptor 1 Rattus norvegicus 101-122 12169105-4 2002 SP(1-7) and capsaicin each increased NK-1 receptor mRNA in the spinal cord (6 h) followed by an increase in NK-1 receptor-immunoreactivity (24 h and 1 week). Capsaicin 12-21 tachykinin receptor 1 Rattus norvegicus 37-50 12169105-4 2002 SP(1-7) and capsaicin each increased NK-1 receptor mRNA in the spinal cord (6 h) followed by an increase in NK-1 receptor-immunoreactivity (24 h and 1 week). Capsaicin 12-21 tachykinin receptor 1 Rattus norvegicus 108-121 12169105-6 2002 Instead, D-SP(1-7) prevented the upregulation of NK-1 receptor immunoreactivity that was induced by capsaicin injected intrathecally, suggesting that the effect of capsaicin is also mediated by SP N-terminal metabolites. Capsaicin 100-109 tachykinin receptor 1 Rattus norvegicus 49-62 12169105-6 2002 Instead, D-SP(1-7) prevented the upregulation of NK-1 receptor immunoreactivity that was induced by capsaicin injected intrathecally, suggesting that the effect of capsaicin is also mediated by SP N-terminal metabolites. Capsaicin 164-173 tachykinin receptor 1 Rattus norvegicus 49-62 10444445-6 1999 Excitation of pancreatic sensory nerves using capsaicin (in the absence of SP) inhibited both amylase and pancreatic juice flow via activation of the NK1 receptor. Capsaicin 46-55 tachykinin receptor 1 Rattus norvegicus 150-162 10193773-7 1999 This difference was not gender-specific and responses to capsaicin were abolished by pretreatment with a selective NK1 receptor antagonist SR 140333 (360 nmol kg(-1)). Capsaicin 57-66 tachykinin receptor 1 Rattus norvegicus 115-127 11000441-0 2000 Neonatal capsaicin treatment decreased substance P receptor immunoreactivity in lamina III neurons of the dorsal horn. Capsaicin 9-18 tachykinin receptor 1 Rattus norvegicus 39-59 7864147-6 1995 Pretreatment with the NK1 receptor antagonist CP-96,345 (4 mg/kg iv), before challenge with substance P, capsaicin, or aerosol hypertonic saline, reduced the amount of neutrophil adhesion by 56%, 93%, and 57% and reduced the amount of eosinophil adhesion by 70%, 83%, and 65%, respectively. Capsaicin 105-114 tachykinin receptor 1 Rattus norvegicus 22-34 9274806-10 1997 In contracted intrapulmonary bronchi that had been treated with compound 48/80, substance P and capsaicin caused relaxation responses that were inhibited markedly or were nearly abolished by the NK1 receptor antagonist, RP67580, by meclofenamate, and by denuding the epithelium. Capsaicin 96-105 tachykinin receptor 1 Rattus norvegicus 195-207 8864563-7 1996 Capsaicin-induced hyperalgesia was prevented and reversed by the NK1 receptor antagonists CP 99994 (100 nmol) and RP 67580 (1 nmol). Capsaicin 0-9 tachykinin receptor 1 Rattus norvegicus 65-77 9457490-6 1998 FK224, a dual antagonist of tachykinin NK1 and NK2 receptors, and FK888, a selective antagonist of NK1 receptor, significantly inhibited capsaicin-induced plasma exudation in the pharynx. Capsaicin 137-146 tachykinin receptor 1 Rattus norvegicus 99-111 7847182-3 1994 We also determined the effects of these peptidase inhibitors, and the NK-1 receptor antagonist L-703,606, on the plasma extravasation produced by capsaicin, which releases tachykinins endogenously from sensory nerve endings. Capsaicin 146-155 tachykinin receptor 1 Rattus norvegicus 70-83 8101362-5 1993 Selective neurokinin-1 receptor antagonists blocked the chemonociceptive reflex produced by topical application of capsaicin with the rank order of potency (lowest effective dose in brackets): GR 82,334 (1 nmol/rat) > RP 67,580 (10 nmol/rat) > (+/-)CP 96,345 (100 nmol/rat). Capsaicin 115-124 tachykinin receptor 1 Rattus norvegicus 10-31 7680798-4 1993 Dorsal horn neurons activated by the capsaicin-evoked input were also excited by a 1-min perfusion of the neurokinin-1 receptor agonists substance P methyl ester or GR73 632 and by the neurokinin-2 agonist neurokinin-A. Capsaicin 37-46 tachykinin receptor 1 Rattus norvegicus 106-127 7684305-19 1993 The foregoing results demonstrate that the non-peptide NK1-receptor antagonist, RP67580, is a potent inhibitor of plasma extravasation induced in skin by NK1-receptor agonists, by local application of chemical irritants (capsaicin or xylene) or by electrical nerve stimulation. Capsaicin 221-230 tachykinin receptor 1 Rattus norvegicus 55-67