PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33140501-9 2021 Further, dUTPase inhibition has the potential to maximize the antitumor activity of fluoropyrimidines in cancers that are defective in BER or HR. fluoropyrimidines 84-101 Deoxyuridine triphosphatase Drosophila melanogaster 9-16 24452393-0 2014 First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers. fluoropyrimidines 107-124 Deoxyuridine triphosphatase Drosophila melanogaster 128-135 29748212-3 2018 TAS-114 strongly and competitively inhibited deoxyuridine 5"-triphosphate nucleotidohydrolase (dUTPase), a gatekeeper protein preventing aberrant base incorporation into DNA, and enhanced the cytotoxicity of fluoropyrimidines in cancer cells; however, it had little intrinsic activity. fluoropyrimidines 208-225 Deoxyuridine triphosphatase Drosophila melanogaster 95-102 33824328-5 2021 Targeting dUTPase and inducing uracil misincorporation during the repair of DNA damage induced by fluoropyrimidines or anthracyclines represents an effective strategy to induce cell lethality. fluoropyrimidines 98-115 Deoxyuridine triphosphatase Drosophila melanogaster 10-17 21780905-6 2011 Results indicate that RNAi silencing of dUTPase induces a complex cellular response wherein sensitivity towards fluoropyrimidines and gene expression levels of related enzymes are both modulated. fluoropyrimidines 112-129 Deoxyuridine triphosphatase Drosophila melanogaster 40-47 19015155-8 2009 The suppression of dUTPase by oxaliplatin promoted increased levels of dUTP that was enhanced by subsequent addition of fluoropyrimidines. fluoropyrimidines 120-137 Deoxyuridine triphosphatase Drosophila melanogaster 19-26 8162567-1 1994 Recent studies from our laboratory suggested that, in some human colorectal tumor cell lines, sensitivity to fluorodeoxyuridine may depend upon the extent of dUTP accumulation that occurs following drug treatment and that elevation of dUTPase activity might be the basis for some instances of resistance to fluoropyrimidines. fluoropyrimidines 307-324 Deoxyuridine triphosphatase Drosophila melanogaster 235-242 33824328-6 2021 dUTPase inhibition significantly sensitised TNBC cell lines to fluoropyrimidines and anthracyclines through imbalanced nucleotide pools and increased DNA damage leading to decreased proliferation and increased cell death. fluoropyrimidines 63-80 Deoxyuridine triphosphatase Drosophila melanogaster 0-7