PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33824328-5	2021	Targeting dUTPase and inducing uracil misincorporation during the repair of DNA damage induced by fluoropyrimidines or anthracyclines represents an effective strategy to induce cell lethality.	fluoropyrimidines	98-115	Deoxyuridine triphosphatase	Drosophila melanogaster	10-17	
8162567-1	1994	Recent studies from our laboratory suggested that, in some human colorectal tumor cell lines, sensitivity to fluorodeoxyuridine may depend upon the extent of dUTP accumulation that occurs following drug treatment and that elevation of dUTPase activity might be the basis for some instances of resistance to fluoropyrimidines.	fluoropyrimidines	307-324	Deoxyuridine triphosphatase	Drosophila melanogaster	235-242	
33824328-6	2021	dUTPase inhibition significantly sensitised TNBC cell lines to fluoropyrimidines and anthracyclines through imbalanced nucleotide pools and increased DNA damage leading to decreased proliferation and increased cell death.	fluoropyrimidines	63-80	Deoxyuridine triphosphatase	Drosophila melanogaster	0-7	
33140501-9	2021	Further, dUTPase inhibition has the potential to maximize the antitumor activity of fluoropyrimidines in cancers that are defective in BER or HR.	fluoropyrimidines	84-101	Deoxyuridine triphosphatase	Drosophila melanogaster	9-16	
29748212-3	2018	TAS-114 strongly and competitively inhibited deoxyuridine 5"-triphosphate nucleotidohydrolase (dUTPase), a gatekeeper protein preventing aberrant base incorporation into DNA, and enhanced the cytotoxicity of fluoropyrimidines in cancer cells; however, it had little intrinsic activity.	fluoropyrimidines	208-225	Deoxyuridine triphosphatase	Drosophila melanogaster	95-102	
24452393-0	2014	First-in-human, phase I dose-escalation study of single and multiple doses of a first-in-class enhancer of fluoropyrimidines, a dUTPase inhibitor (TAS-114) in healthy male volunteers.	fluoropyrimidines	107-124	Deoxyuridine triphosphatase	Drosophila melanogaster	128-135	
21780905-6	2011	Results indicate that RNAi silencing of dUTPase induces a complex cellular response wherein sensitivity towards fluoropyrimidines and gene expression levels of related enzymes are both modulated.	fluoropyrimidines	112-129	Deoxyuridine triphosphatase	Drosophila melanogaster	40-47	
19015155-8	2009	The suppression of dUTPase by oxaliplatin promoted increased levels of dUTP that was enhanced by subsequent addition of fluoropyrimidines.	fluoropyrimidines	120-137	Deoxyuridine triphosphatase	Drosophila melanogaster	19-26