PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21374032-3	1999	Several cellular targets for fluoropyrimidines have been well-characterized, including inhibition of thymidylate synthase (TS) by fluorodeoxyuridine monophosphate (FdUMP) and false base incorporation into RNA or DNA.	fluoropyrimidines	29-46	thymidylate synthase	Mus musculus	101-121	
22824673-0	2012	A thymidylate synthase ternary complex-specific antibody, FTS, permits functional monitoring of fluoropyrimidines dosing.	fluoropyrimidines	96-113	thymidylate synthase	Mus musculus	2-22	
22824673-1	2012	5-Fluorouracil (5FU) and similar fluoropyrimidines induce covalent modification of thymidylate synthase (TS) and inhibit its activity.	fluoropyrimidines	33-50	thymidylate synthase	Mus musculus	83-103	
22824673-1	2012	5-Fluorouracil (5FU) and similar fluoropyrimidines induce covalent modification of thymidylate synthase (TS) and inhibit its activity.	fluoropyrimidines	33-50	thymidylate synthase	Mus musculus	105-107	
8509220-12	1993	In contrast, the activity of thymidylate synthase, the target enzyme for fluoropyrimidines, was higher in the wild-type cells.	fluoropyrimidines	73-90	thymidylate synthase	Mus musculus	29-49	
9816304-0	1996	Therapeutic efficacy of fluoropyrimidines depends on the duration of thymidylate synthase inhibition in the murine colon 26-B carcinoma tumor model.	fluoropyrimidines	24-41	thymidylate synthase	Mus musculus	69-89	
2971656-6	1988	These results are in accord with the concept that folinic acid augments the effects of the fluoropyrimidines by expansion of cellular 5,10-CH2-H4PteGlun pools with subsequent stabilization of ternary complexes among 5-fluoro-2"-deoxyuridine 5"-monophosphate, TS, and 5,10-CH2-H4PteGlun.	fluoropyrimidines	91-108	thymidylate synthase	Mus musculus	259-261	
2971656-7	1988	In light of the accumulation of TS that occurs following exposure to fluoropyrimidines, this stabilization may be needed for efficient tumor cell killing by these agents.	fluoropyrimidines	69-86	thymidylate synthase	Mus musculus	32-34	
2944577-9	1986	We conclude that folinic acid stabilizes the effects of the fluoropyrimidines on thymidylate synthase of both mouse and human leukemic cell populations and that this enhancement is reflected in both inhibition of the growth of and the lethality to these cells.	fluoropyrimidines	60-77	thymidylate synthase	Mus musculus	81-101	
2944577-10	1986	We suggest that only doses of the fluoropyrimidines that are capable of initially inhibiting thymidylate synthase to a high degree will be synergistic with excess reduced folates.	fluoropyrimidines	34-51	thymidylate synthase	Mus musculus	93-113