PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28405246-10 2017 To interpret these complicated outcomes, we propose a hypothesis that CYP1A1 is a key enzyme for both generation and reduction of (+-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), the major carcinogenic intermediate of BaP. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 178-182 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 70-76 27162022-8 2016 Our findings cumulatively suggest that resveratrol inhibits conversion of B(a)P into BPDE by modulating the transcriptional regulation of CYP1A1 and acting as an antioxidant thus prevents B(a)P-induced oxidative stress and testicular apoptosis. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 85-89 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 138-144 27162022-5 2016 Resveratrol cotreatment resulted inhibition of testicular cytochrome P4501A1 (CYP1A1) expression, which is the major B(a)P metabolizing agent for BPDE-DNA adduct formation. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 146-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 58-76 27162022-5 2016 Resveratrol cotreatment resulted inhibition of testicular cytochrome P4501A1 (CYP1A1) expression, which is the major B(a)P metabolizing agent for BPDE-DNA adduct formation. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 146-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-84 12507920-3 2002 In this review, we summarize the published data on modulation of (+)-anti-BPDE-DNA adduct levels in smokers" lungs by CYP1A1*2 genotypes alone or in combination with GSTM1 polymorphism and compare these results with those reported for aromatic/hydrophobic (bulky) DNA adducts. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 74-78 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 118-124 20399842-2 2010 BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 37-73 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 145-151 20399842-2 2010 BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 75-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 145-151 20596254-3 2010 Our previous report indicated that BPDE-like DNA adduct levels in pterygium were associated with CYP1A1 gene polymorphisms. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 35-39 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 97-103 20700368-3 2010 The relationship between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 gene polymorphisms in pterygium is not clear. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 25-29 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 57-63 20700368-9 2010 Additionally, the risk of BPDE-like DNA adduct formation for patients with CYP1A1 m1/m2 (C/T) andm2/m2 (T/T) was 9.675 fold higher than that of patients with CYP1A1 m1/m1 (C/C) types (p=0.001, 95% Confidence Interval 2.451-38.185). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 26-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 75-81 20700368-9 2010 Additionally, the risk of BPDE-like DNA adduct formation for patients with CYP1A1 m1/m2 (C/T) andm2/m2 (T/T) was 9.675 fold higher than that of patients with CYP1A1 m1/m1 (C/C) types (p=0.001, 95% Confidence Interval 2.451-38.185). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 26-30 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 158-164 16557497-4 2006 Further CYP1A1- and/or CYP1B1-mediated activation of the dihydrodiol results in the formation of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]PDE), the ultimate carcinogen. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 97-155 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 8-14 15808407-10 2005 Overall the data suggest that BPDE-DNA adduct levels in normal human breast tissue may be modulated by multiple factors that include, but are not exclusive to, CYP1A1 and CYP1B1 inducibility and the presence or absence of GSTM1. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 30-34 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 160-166 23036853-10 2013 Further experiments using "Tet-On" cytochrome P450 1A1-overexpressing cells and a recombinant cytochrome P450 1A1 enzyme demonstrated that this is the key enzyme involved in the biotransformation of BaP, that is, both production and inactivation of BPDE. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 249-253 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 35-54 23036853-10 2013 Further experiments using "Tet-On" cytochrome P450 1A1-overexpressing cells and a recombinant cytochrome P450 1A1 enzyme demonstrated that this is the key enzyme involved in the biotransformation of BaP, that is, both production and inactivation of BPDE. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 249-253 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-113 22876118-11 2012 In the cell model, CYP1A1 protein expression and b[a]P 7,8-diol 9,10-epoxide (BPDE)-like DNA adducts increased in CYP1A1 m2/m2 (genotype T/T) PEC cells as compared with m1/m2 (genotype C/T) and m1/m1 (genotype C/C) cells. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 78-82 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 114-120 20700368-0 2010 An association between BPDE-like DNA adduct levels and CYP1A1 and GSTM1 polymorphisma in pterygium. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 23-27 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 55-61 15298956-0 2004 Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 0-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 108-114 15298956-0 2004 Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 28-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 108-114 15298956-8 2004 In conclusion, CYP1A1, GSTM1, and GSTP1 genotyping seems to be a risk predictor of BPDE-DNA adduct formation in leukocytes. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 83-87 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 15-21 12507920-5 2002 In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 44-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-104 12507920-5 2002 In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 44-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 220-226 12507920-5 2002 In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 44-48 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 220-226 12507920-5 2002 In contrast, a clear dependence of (+)-anti-BPDE-DNA adduct levels was found as a function of the CYP1A1 and GSTM1 genotypes: In lung parenchyma, this adduct was more pronounced in persons with the GSTM1*0 genotype, and CYP1A1*2-GSTM1*0 carriers had higher (+)-anti-BPDE-DNA adduct levels than those with CYP1A1*1/*1-GSTM1*0. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 266-270 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-104 23889309-0 2001 Benzo(a)pyrene diolepoxide adducts to albumin in workers exposed to polycyclic aromatic hydrocarbons: association with specific CYP1A1, GSTM1, GSTP1 and EHPX genotypes. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 0-26 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 128-134 10607731-0 2000 Modulation of benzo[a]pyrene diolepoxide-DNA adduct levels in human white blood cells by CYP1A1, GSTM1 and GSTT1 polymorphism. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 14-40 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 89-95 10607731-1 2000 The modulation of benzo[a]pyrene diolepoxide (BPDE)-DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of Caucasian males. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 46-50 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 10607731-13 2000 Higher levels of BPDE-DNA adducts in individuals with the combined CYP1A1(1/*2 or *2A/*2A)-GSTM1*0/*0 genotype suggest that these genotype combinations are at increased risk for contracting lung cancer when exposed to PAH. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 17-21 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 67-73 10607731-1 2000 The modulation of benzo[a]pyrene diolepoxide (BPDE)-DNA adduct levels by polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes was assessed in leukocytes of Caucasian males. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 18-44 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 94-100 10571654-5 1999 Results from lung cancer patients and PAH-exposed coke oven workers correlated CYP1A1-GSTM1 genotype combinations with BPDE-DNA adduct levels. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 119-123 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 79-85 8692183-5 1996 In smokers, a positive correlation was found between pulmonary CYP1A1-related catalytic activity (AHH) and the level of lung BPDE-DNA adducts. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 125-129 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 63-69 9718223-11 1998 These results are based on a small number of observations thus far, but this exploratory study suggests that CYPIA1 and mEH variants might have an impact on BPDE exposure markers such as BPDE-SA adducts. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 157-161 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 109-115 9679569-7 1998 Similarly, V79MZr1A1 cells that express CYP1A1 and either transfected human or murine GSTP1-1 (< 5000 mIU/mg, CDNB) exhibited > 70% decrease in covalent labeling of total nucleic acids by [3H]BPDE. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 198-202 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 40-46 10022748-0 1998 High benzo[a]pyrene diol-epoxide DNA adduct levels in lung and blood cells from individuals with combined CYP1A1 MspI/Msp-GSTM1*0/*0 genotypes. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 5-32 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 106-112 10026994-9 1998 Further genetic analyses confirmed that the combination of CYP1A1 homozygous mutants and GSTM1 inactive leads to high levels of BPDE-DNA adducts in human lung of smokers and white blood cells of PAH-exposed coke oven workers. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 128-132 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 59-65 8692183-5 1996 In smokers, a positive correlation was found between pulmonary CYP1A1-related catalytic activity (AHH) and the level of lung BPDE-DNA adducts. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 125-129 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 98-101 7662121-10 1995 The principal adduct formed by both CYP1A1-metabolized BPD and exogenously supplied BPDE was 10-beta-(deoxyguanosin-N2-yl)-7 beta,8 alpha,9 alpha-trihydroxy-7,8,9,10- tetrahydrobenzo[a]pyrene, indicating that the differential effects of BPD- and BPDE-induced adducts were not due to a difference in the types of adducts formed. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 246-250 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 36-42 7662121-3 1995 The XPA cells were more susceptible than the normal cells to the cytotoxic effects of both CYP1A1-metabolized BPD and exogenously supplied (+/-)-anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10- epoxide (BPDE). 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 202-206 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 91-97 7581497-6 1995 Most important was the finding, that human cytochrome P450 1A1 almost exclusively oxidized benzo[a]pyrene in the 7,8,9,10-position, yielding the ultimate carcinogen 7,8-dihydroxy-9,10-epoxy-7,8,9, 10-tetrahydrobenzo[a]pyrene whereas the rat cytochrome P450 1A1 oxidized benzo[]pyrene in the 4,5-position and 7,8,9,10-position. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide 165-224 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 43-62