PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20399842-2	2010	BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	37-73	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	161-167	
27188524-6	2016	CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	114-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-6	
27188524-6	2016	CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	114-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	35-41	
27188524-6	2016	CYP1B1*1/*1 wild-type subjects and CYP1B1*3/*1 heterozygotes for rs1056836 formed significantly higher amounts of BPDE-DNA adducts than CYP1B1*3/*3 homozygotes (p=0.031 and p=0.005, respectively).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	114-118	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	35-41	
20399842-2	2010	BP is converted in liver and lung to benzo(a)pyrene-7,8-diol-9,10-epoxide (BPDE) by the enzymes of the cytochrome P450 (CYP) superfamily, namely CYP1A1/1A2, and CYP1B1.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	75-79	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	161-167	
18489080-2	2008	P4501A1/P4501B1 plus epoxide hydrolase activate PAH to (+/-)- anti-benzo[ a]pyrene diol epoxide ((+/-)- anti-BPDE), which causes bulky DNA adducts.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	109-113	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	8-15	
16557497-4	2006	Further CYP1A1- and/or CYP1B1-mediated activation of the dihydrodiol results in the formation of 7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (B[a]PDE), the ultimate carcinogen.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	97-155	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	23-29	
15808407-10	2005	Overall the data suggest that BPDE-DNA adduct levels in normal human breast tissue may be modulated by multiple factors that include, but are not exclusive to, CYP1A1 and CYP1B1 inducibility and the presence or absence of GSTM1.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	30-34	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	171-177	
15720144-9	2005	The system with a relatively higher concentration of NADPH favored formation of anti-BPDE via P450 1A1/P450 1B1, while the system with the higher concentration of NAD+ favored formation of BP-7,8-dione via AKR1A1.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	85-89	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	94-111	
1423269-9	1992	A highly significant correlation was found between pulmonary microsomal aryl hydrocarbon hydroxylase activity and the level of benzo(a)pyrene diolepoxide-DNA adduct (r = 0.91; P < 0.001; n = 13).	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	127-153	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	72-100