PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11864911-5	2002	High concentrations of BPDE elicited phosphorylation of both Chk1 and Chk2.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	23-27	checkpoint kinase 2	Homo sapiens	70-74	
15817457-8	2005	The persistent S-phase arrest in BPDE-treated Polk(-/-) cells was associated with increased levels of histone gammaH2AX (a marker of DNA double-strand breaks (DSBs)) and activation of the DSB-responsive kinases ATM and Chk2.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	33-37	checkpoint kinase 2	Homo sapiens	219-223	
17630511-5	2007	The BPDE-mediated accumulation of sub-diploid fraction (apoptotic cells) was significantly decreased in H1299 cells transiently transfected with both Chk1 and Chk2 specific siRNAs.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	4-8	checkpoint kinase 2	Homo sapiens	159-163	
27035420-3	2016	In the present study, it was observed that its genotoxic metabolite, anti-benzopyrene-7,8-diol-9,10-epoxide (BPDE), triggered cell cycle arrest in S-phase in 16HBE cells by activating ataxia-telangiectasia (ATM)/checkpoint kinase (Chk)2 and ATM and Rad3 related (ATR)/Chk1 signaling pathways.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	109-113	checkpoint kinase 2	Homo sapiens	212-236	
27035420-6	2016	It was therefore indicated that NRF-1 overexpression attenuated BPDE-induced S-phase arrest via the ATM/Chk2 signaling pathway.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	64-68	checkpoint kinase 2	Homo sapiens	104-108