PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32967924-0 2020 Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer. mgc018 27-33 CD276 molecule Homo sapiens 89-94 32967924-4 2020 In this article, we report the preclinical development of MGC018, an antibody-drug conjugate targeted against B7-H3. mgc018 58-64 CD276 molecule Homo sapiens 110-115 32967924-5 2020 MGC018 is comprised of the cleavable linker-duocarmycin payload, valine-citrulline-seco duocarmycin hydroxybenzamide azaindole (vc-seco-DUBA), conjugated to an anti-B7-H3 humanized IgG1/kappa monoclonal antibody through reduced interchain disulfides, with an average drug-to-antibody ratio of ~2.7. mgc018 0-6 CD276 molecule Homo sapiens 165-170 32967924-6 2020 MGC018 exhibited cytotoxicity toward B7-H3-positive human tumor cell lines, and exhibited bystander killing of target-negative tumor cells when co-cultured with B7-H3-positive tumor cells. mgc018 0-6 CD276 molecule Homo sapiens 37-42 32967924-6 2020 MGC018 exhibited cytotoxicity toward B7-H3-positive human tumor cell lines, and exhibited bystander killing of target-negative tumor cells when co-cultured with B7-H3-positive tumor cells. mgc018 0-6 CD276 molecule Homo sapiens 161-166