PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7813633-3 1995 The focus of this work was to determine the effects of LPA on the proliferation and differentiation of early passage cultured human keratinocytes with emphasis on determining if transforming growth factors (TGF), types alpha and beta, are induced by LPA. lysophosphatidic acid 250-253 transforming growth factor beta 1 Homo sapiens 207-210 15482469-0 2004 Lysophosphatidic acid interacts with transforming growth factor-beta signaling to mediate keratinocyte growth arrest and chemotaxis. lysophosphatidic acid 0-21 transforming growth factor beta 1 Homo sapiens 37-68 7813633-8 1995 LPA and RA also induced both the active and latent forms TGF beta from cultured keratinocytes. lysophosphatidic acid 0-3 transforming growth factor beta 1 Homo sapiens 57-65 7813633-12 1995 The effects of LPA on TGF alpha and TGF beta production by keratinocytes likely have in vivo relevance as concluded from rodent studies involving topical LPA treatments. lysophosphatidic acid 15-18 transforming growth factor beta 1 Homo sapiens 36-44 7813633-12 1995 The effects of LPA on TGF alpha and TGF beta production by keratinocytes likely have in vivo relevance as concluded from rodent studies involving topical LPA treatments. lysophosphatidic acid 154-157 transforming growth factor beta 1 Homo sapiens 36-44 35445400-6 2022 Extracellular lysophosphatidic acid (LPA) synergistically induced MMT in the presence of TGF-beta1 in mesothelial cells. lysophosphatidic acid 14-35 transforming growth factor beta 1 Homo sapiens 89-98 35445400-6 2022 Extracellular lysophosphatidic acid (LPA) synergistically induced MMT in the presence of TGF-beta1 in mesothelial cells. lysophosphatidic acid 37-40 transforming growth factor beta 1 Homo sapiens 89-98 29930716-4 2018 We previously indicated that LPA may induce alphavbeta6-mediated TGF-beta1 signaling mechanisms during the pathogenesis of lung injury and fibrosis. lysophosphatidic acid 29-32 transforming growth factor beta 1 Homo sapiens 65-74 33427061-1 2021 Lysophosphatidic acid (LPA) increases PDGFB and CTGF production and secretion by proximal tubule (PT) cells through LPA2-receptor-Galphaq-alphavbeta6-integrin mediated activation of TGFB1. lysophosphatidic acid 0-21 transforming growth factor beta 1 Homo sapiens 182-187 33427061-1 2021 Lysophosphatidic acid (LPA) increases PDGFB and CTGF production and secretion by proximal tubule (PT) cells through LPA2-receptor-Galphaq-alphavbeta6-integrin mediated activation of TGFB1. lysophosphatidic acid 23-26 transforming growth factor beta 1 Homo sapiens 182-187 25684348-6 2015 In lysophosphatidic acid (LPA)-challenged WI-38 cells, the expression of IQGAP1 was also decreased, while neutralized anti-TGF-beta antibody treatment restored the LPA-induced inhibition of IQGAP1 expression. lysophosphatidic acid 3-24 transforming growth factor beta 1 Homo sapiens 123-131 25684348-6 2015 In lysophosphatidic acid (LPA)-challenged WI-38 cells, the expression of IQGAP1 was also decreased, while neutralized anti-TGF-beta antibody treatment restored the LPA-induced inhibition of IQGAP1 expression. lysophosphatidic acid 164-167 transforming growth factor beta 1 Homo sapiens 123-131 25684348-6 2015 In lysophosphatidic acid (LPA)-challenged WI-38 cells, the expression of IQGAP1 was also decreased, while neutralized anti-TGF-beta antibody treatment restored the LPA-induced inhibition of IQGAP1 expression. lysophosphatidic acid 26-29 transforming growth factor beta 1 Homo sapiens 123-131 24854244-7 2014 Similarly, lysophosphatidic acid (LPA) induced TGF-beta expression and decreased HO-1 expression in human lung fibroblasts. lysophosphatidic acid 11-32 transforming growth factor beta 1 Homo sapiens 47-55 25175023-7 2014 Similarly, LPA induced beta-catenin expression in human lung fibroblasts, and pre-treatment of the neutralized anti-TGF-beta antibody attenuated the LPA-induced expression of beta-catenin and differentiation in human lung fibroblasts. lysophosphatidic acid 11-14 transforming growth factor beta 1 Homo sapiens 116-124 25175023-7 2014 Similarly, LPA induced beta-catenin expression in human lung fibroblasts, and pre-treatment of the neutralized anti-TGF-beta antibody attenuated the LPA-induced expression of beta-catenin and differentiation in human lung fibroblasts. lysophosphatidic acid 149-152 transforming growth factor beta 1 Homo sapiens 116-124 24116978-14 2014 On the other hand, lysophosphatidic acid, an upstream activator of Rho, increased SZP synthesis in response to TGFbeta1. lysophosphatidic acid 19-40 transforming growth factor beta 1 Homo sapiens 111-119 24854244-7 2014 Similarly, lysophosphatidic acid (LPA) induced TGF-beta expression and decreased HO-1 expression in human lung fibroblasts. lysophosphatidic acid 34-37 transforming growth factor beta 1 Homo sapiens 47-55 24854244-8 2014 Interestingly, pretreatment with neutralized anti-TGF-beta antibody attenuated LPA effects in human lung fibroblasts. lysophosphatidic acid 79-82 transforming growth factor beta 1 Homo sapiens 50-58 23808384-8 2013 In human lung fibroblasts, the knockdown of LPA2 attenuated the LPA-induced expression of TGF-beta1 and the differentiation of lung fibroblasts to myofibroblasts, resulting in the decreased expression of FN, alpha-SMA, and collagen, as well as decreased activation of extracellular regulated kinase 1/2, Akt, Smad3, and p38 mitogen-activated protein kinase. lysophosphatidic acid 44-47 transforming growth factor beta 1 Homo sapiens 90-99 22374302-0 2012 Lysophosphatidic acid activates TGFBIp expression in human corneal fibroblasts through a TGF-beta1-dependent pathway. lysophosphatidic acid 0-21 transforming growth factor beta 1 Homo sapiens 89-98 22374302-5 2012 Accumulating evidence has indicated a crucial role for LPA-induced expression of TGFBI protein (TGFBIp) through secretion of transforming growth factor-beta1 (TGF-beta1). lysophosphatidic acid 55-58 transforming growth factor beta 1 Homo sapiens 125-157 22374302-5 2012 Accumulating evidence has indicated a crucial role for LPA-induced expression of TGFBI protein (TGFBIp) through secretion of transforming growth factor-beta1 (TGF-beta1). lysophosphatidic acid 55-58 transforming growth factor beta 1 Homo sapiens 159-168 22374302-8 2012 LPA induced secretion of TGF-beta1 in corneal fibroblasts, and pretreatment with the TGF-beta type I receptor kinase inhibitor SB431542 or an anti-TGF-beta1 neutralizing antibody also inhibited LPA-induced TGFBIp expression. lysophosphatidic acid 0-3 transforming growth factor beta 1 Homo sapiens 25-34 22374302-8 2012 LPA induced secretion of TGF-beta1 in corneal fibroblasts, and pretreatment with the TGF-beta type I receptor kinase inhibitor SB431542 or an anti-TGF-beta1 neutralizing antibody also inhibited LPA-induced TGFBIp expression. lysophosphatidic acid 0-3 transforming growth factor beta 1 Homo sapiens 147-156 22374302-8 2012 LPA induced secretion of TGF-beta1 in corneal fibroblasts, and pretreatment with the TGF-beta type I receptor kinase inhibitor SB431542 or an anti-TGF-beta1 neutralizing antibody also inhibited LPA-induced TGFBIp expression. lysophosphatidic acid 194-197 transforming growth factor beta 1 Homo sapiens 25-34 22374302-8 2012 LPA induced secretion of TGF-beta1 in corneal fibroblasts, and pretreatment with the TGF-beta type I receptor kinase inhibitor SB431542 or an anti-TGF-beta1 neutralizing antibody also inhibited LPA-induced TGFBIp expression. lysophosphatidic acid 194-197 transforming growth factor beta 1 Homo sapiens 147-156 18065393-6 2008 LPA-induced secretion of transforming growth factor (TGF)-beta1 in hADSCs, and pretreatment of the cells with SB431542, a TGF-beta type I receptor kinase inhibitor, or anti-TGF-beta1 neutralizing antibody inhibited the LPA-induced expression of alpha-SMA and phosphorylation of Smad2. lysophosphatidic acid 219-222 transforming growth factor beta 1 Homo sapiens 173-182 22309779-4 2012 Here, we show that agonists of G-protein coupled receptors (Sphingosine-1-Phosphate and Lysophosphatidic Acid) which are ligated under conditions of epithelial injury directly stimulate primary airway epithelial cells to activate latent TGF-beta through a pathway that involves Rho Kinase, non-muscle myosin, the alpha(v)beta(6) integrin, and the generation of mechanical tension. lysophosphatidic acid 88-109 transforming growth factor beta 1 Homo sapiens 237-245 21890597-0 2011 Lysophosphatidic acid-induced p21Waf1 expression mediates the cytostatic response of breast and ovarian cancer cells to TGFbeta. lysophosphatidic acid 0-21 transforming growth factor beta 1 Homo sapiens 120-127 21890597-3 2011 In this study, we showed that LPA upregulated expression of the cyclin-dependent kinase inhibitor p21(Waf1) in TGFbeta-sensitive breast and ovarian cancer cells, but not in TGFbeta-resistant ones. lysophosphatidic acid 30-33 transforming growth factor beta 1 Homo sapiens 111-118 21890597-4 2011 We examined the possibility that LPA-induced p21 might contribute to the cytostatic response to TGFbeta. lysophosphatidic acid 33-36 transforming growth factor beta 1 Homo sapiens 96-103 21890597-6 2011 Serum or serum-borne LPA cooperated with TGFbeta to elicit the maximal p21 induction. lysophosphatidic acid 21-24 transforming growth factor beta 1 Homo sapiens 41-48 21890597-9 2011 Our results reveal a novel cross-talk between LPA and TGFbeta that underlies TGFbeta-sensitive and -resistant phenotypes of breast and ovarian cancer cells. lysophosphatidic acid 46-49 transforming growth factor beta 1 Homo sapiens 77-84 20862207-5 2010 Interestingly, these results revealed that LPA treatment upregulates several TGF-beta1 target genes, including laminin-332 (Ln-332) components (alpha3, beta3, and gamma2 chains). lysophosphatidic acid 43-46 transforming growth factor beta 1 Homo sapiens 77-86 20862207-6 2010 Western blot analysis also showed that LPA increased phosphorylation of Smad2, an event that is carried out by TGF-beta1 interactions. lysophosphatidic acid 39-42 transforming growth factor beta 1 Homo sapiens 111-120 18065393-9 2008 These results suggest that cancer-derived LPA stimulates differentiation of hADSCs to myofibroblast-like cells and increases SDF-1 expression through activating autocrine TGF-beta1-Smad signaling pathway. lysophosphatidic acid 42-45 transforming growth factor beta 1 Homo sapiens 171-180 17093396-6 2006 RESULTS: Treatment of human TM cells treated with either serum or transforming growth factor-beta 1 led to a robust stimulation, compared to thrombin, lysophosphatidic acid (LPA), and dexamethasone, which elicited a relatively moderate induction of CTGF expression. lysophosphatidic acid 151-172 transforming growth factor beta 1 Homo sapiens 66-99 17093396-6 2006 RESULTS: Treatment of human TM cells treated with either serum or transforming growth factor-beta 1 led to a robust stimulation, compared to thrombin, lysophosphatidic acid (LPA), and dexamethasone, which elicited a relatively moderate induction of CTGF expression. lysophosphatidic acid 174-177 transforming growth factor beta 1 Homo sapiens 66-99 17250650-2 2007 In this study, we report that agonists for G protein-coupled receptors (GPCRs), including endothelin, lysophosphatidic acid and carbachol, effectively promote the expression of SMC-specific proteins in the presence of transforming growth factor-beta (TGF-beta). lysophosphatidic acid 102-123 transforming growth factor beta 1 Homo sapiens 218-249 17250650-2 2007 In this study, we report that agonists for G protein-coupled receptors (GPCRs), including endothelin, lysophosphatidic acid and carbachol, effectively promote the expression of SMC-specific proteins in the presence of transforming growth factor-beta (TGF-beta). lysophosphatidic acid 102-123 transforming growth factor beta 1 Homo sapiens 251-259